Journal Article: Limited recognition of highly conserved regions of SARS-CoV-2
Swaminathan, Srividhya, Lineburg, Katie E., Ambalathingal, George R., Crooks, Pauline, Grant, Emma J., Mohan, Sonali V., Raju, Jyothy, Panikkar, Archana, Le Texier, Laetitia, Tong, Zheng Wei Marcus, Chew, Keng Yih, Neller, Michelle A., Short, Kirsty R., Gowda, Harsha, Gras, Stephanie, Khanna, Rajiv and Smith, Corey (2022). Limited recognition of highly conserved regions of SARS-CoV-2. Microbiology Spectrum, 10 (1) e02780-21. doi: 10.1128/spectrum.02780-21
Journal Article: SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants
Panikkar, Archana, Lineburg, Katie E., Raju, Jyothy, Chew, Keng Yih, Ambalathingal, George R., Rehan, Sweera, Swaminathan, Srividhya, Crooks, Pauline, Le Texier, Laetitia, Beagley, Leone, Best, Shannon, Solomon, Matthew, Matthews, Katherine K., Srihari, Sriganesh, Neller, Michelle A., Short, Kirsty R., Khanna, Rajiv and Smith, Corey (2022). SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants. PLoS Pathogens, 18 (2) e1010339, e1010339. doi: 10.1371/journal.ppat.1010339
Journal Article: Author Correction: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses
McMillan, Christopher L. D., Cheung, Stacey T. M., Modhiran, Naphak, Barnes, James, Amarilla, Alberto A., Bielefeldt-Ohmann, Helle, Lee, Leo Yi Yang, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Jakob, Virginie, Lebas, Celia, Reading, Patrick, Short, Kirsty R., Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2022). Author Correction: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. npj Vaccines, 7 (1) 3, 3. doi: 10.1038/s41541-021-00428-y
(2022–2026) NHMRC Investigator Grants
An integrated analytical network for protein characterisation
(2022–2023) ARC Linkage Infrastructure, Equipment and Facilities
Harnessing Oxidised Cholesterols to Reduce Susceptibility to COVID-19 in Obesity and Diabetes
(2022) Diabetes Australia Research Program
The Role of Host Co-morbidities in Influenza Severity
Doctor Philosophy
Genesis and Pathognesis of avain influenza
Doctor Philosophy
Avian Genomics and Transcriptomics to understand the Pathogenesis of Highly Pathogenic Avian Influenza Virus in Black Swans
Doctor Philosophy
Nasopharyngeal colonization with Streptococcus pneumoniae
Short, Kirsty R. and Diavatopoulos, Dimitri A. (2015). Nasopharyngeal colonization with Streptococcus pneumoniae. Streptococcus Pneumoniae: molecular mechanisms of host-pathogen interactions. (pp. 279-291) edited by Jeremy Brown, Sven Hammerschmidt and Carlos Orihuela. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-410530-0.00015-6
Limited recognition of highly conserved regions of SARS-CoV-2
Swaminathan, Srividhya, Lineburg, Katie E., Ambalathingal, George R., Crooks, Pauline, Grant, Emma J., Mohan, Sonali V., Raju, Jyothy, Panikkar, Archana, Le Texier, Laetitia, Tong, Zheng Wei Marcus, Chew, Keng Yih, Neller, Michelle A., Short, Kirsty R., Gowda, Harsha, Gras, Stephanie, Khanna, Rajiv and Smith, Corey (2022). Limited recognition of highly conserved regions of SARS-CoV-2. Microbiology Spectrum, 10 (1) e02780-21. doi: 10.1128/spectrum.02780-21
Panikkar, Archana, Lineburg, Katie E., Raju, Jyothy, Chew, Keng Yih, Ambalathingal, George R., Rehan, Sweera, Swaminathan, Srividhya, Crooks, Pauline, Le Texier, Laetitia, Beagley, Leone, Best, Shannon, Solomon, Matthew, Matthews, Katherine K., Srihari, Sriganesh, Neller, Michelle A., Short, Kirsty R., Khanna, Rajiv and Smith, Corey (2022). SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants. PLoS Pathogens, 18 (2) e1010339, e1010339. doi: 10.1371/journal.ppat.1010339
McMillan, Christopher L. D., Cheung, Stacey T. M., Modhiran, Naphak, Barnes, James, Amarilla, Alberto A., Bielefeldt-Ohmann, Helle, Lee, Leo Yi Yang, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Jakob, Virginie, Lebas, Celia, Reading, Patrick, Short, Kirsty R., Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2022). Author Correction: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. npj Vaccines, 7 (1) 3, 3. doi: 10.1038/s41541-021-00428-y
Mayfield, Helen J., Lau, Colleen L., Sinclair, Jane E., Brown, Samuel J., Baird, Andrew, Litt, John, Vuorinen, Aapeli, Short, Kirsty R., Waller, Michael and Mengersen, Kerrie (2022). Designing an evidence-based Bayesian network for estimating the risk versus benefits of AstraZeneca COVID-19 vaccine. Vaccine, 40 (22), 3072-3084. doi: 10.1016/j.vaccine.2022.04.004
Kulasinghe, Arutha, Tan, Chin Wee, dos Santos Miggiolaro, Anna Flavia Ribeiro, Monkman, James, SadeghiRad, Habib, Bhuva, Dharmesh D., da Silva Motta Junior, Jarbas, Vaz de Paula, Caroline Busatta, Nagashima, Seigo, Baena, Cristina Pellegrino, Souza-Fonseca-Guimaraes, Paulo, de Noronha, Lucia, McCulloch, Timothy, Rodrigues Rossi, Gustavo, Cooper, Caroline, Tang, Benjamin, Short, Kirsty R., Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Belz, Gabrielle T. and O'Byrne, Ken (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59 (6) 2101881, 1-19. doi: 10.1183/13993003.01881-2021
Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses
McMillan, Christopher L. D., Cheung, Stacey T. M., Modhiran, Naphak, Barnes, James, Amarilla, Alberto A., Bielefeldt-Ohmann, Helle, Lee, Leo Yi Yang, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Jakob, Virginie, Lebas, Celia, Reading, Patrick, Short, Kirsty R., Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2021). Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. npj Vaccines, 6 (1) 135, 135. doi: 10.1038/s41541-021-00395-4
Lau, Colleen L, Mayfield, Helen J, Sinclair, Jane E, Brown, Samuel J, Waller, Michael, Enjeti, Anoop K, Baird, Andrew, Short, Kirsty, Mengersen, Kerrie and Litt, John (2021). Risk-benefit analysis of the AstraZeneca COVID-19 vaccine in Australia using a Bayesian network modelling framework. Vaccine, 39 (51), 7429-7440. doi: 10.1016/j.vaccine.2021.10.079
Hulme, Katina D., Noye, Ellesandra C., Short, Kirsty R. and Labzin, Larisa I. (2021). Dysregulated inflammation during obesity: driving disease severity in influenza virus and SARS-CoV-2 infections. Frontiers in Immunology, 12 770066, 770066. doi: 10.3389/fimmu.2021.770066
Endothelial cells are not productively infected by SARS‐CoV‐2
Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis
Yekelchyk, Michail, Madan, Esha, Wilhelm, Jochen, Short, Kirsty R, Palma, António M, Liao, Linbu, Camacho, Denise, Nkadori, Everlyne, Winters, Michael T, Rice, Emily S, Rolim, Inês, Cruz‐Duarte, Raquel, Pelham, Christopher J, Nagane, Masaki, Gupta, Kartik, Chaudhary, Sahil, Braun, Thomas, Pillappa, Raghavendra, Parker, Mark S, Menter, Thomas, Matter, Matthias, Haslbauer, Jasmin Dionne, Tolnay, Markus, Galior, Kornelia D, Matkwoskyj, Kristina A, McGregor, Stephanie M, Muller, Laura K, Rakha, Emad A, Lopez‐Beltran, Antonio ... Gogna, Rajan (2021). Flower lose, a cell fitness marker, predicts COVID‐19 prognosis. EMBO Molecular Medicine, 13 (11) e13714, e13714. doi: 10.15252/emmm.202013714
Zhou, Pengcheng, Chen, Jiali, He, Jing, Zheng, Ting, Yunis, Joseph, Makota, Victor, Alexandre, Yannick O., Gong, Fang, Zhang, Xia, Xie, Wuxiang, Li, Yuhui, Shao, Miao, Zhu, Yanshan, Sinclair, Jane E., Miao, Miao, Chen, Yaping, Short, Kirsty R., Mueller, Scott N., Sun, Xiaolin, Yu, Di and Li, Zhanguo (2021). Low-dose IL-2 therapy invigorates CD8+ T cells for viral control in systemic lupus erythematosus with a potential risk of deteriorating immunopathology. PLoS Pathogens, 17 (10) e1009858, e1009858. doi: 10.1371/journal.ppat.1009858
Mazzone, Stuart B., Yang, Seung-Kwon, Keller, Jennifer A., Simanauskaite, Juste, Arikkatt, Jaisy, Fogarty, Matthew J., Moe, Aung Aung Kywe, Chen, Chen, Trewella, Matthew W., Tian, Luyi, Ritchie, Matthew E., Chua, Brendan Y., Phipps, Simon, Short, Kirsty R. and McGovern, Alice E. (2021). Modulation of vagal sensory neurons via high mobility group box-1 and receptor for advanced glycation end products: implications for respiratory viral infections. Frontiers in Physiology, 12 744812, 744812. doi: 10.3389/fphys.2021.744812
Type I diabetes mellitus increases the cardiovascular complications of influenza virus infection
Sinclair, Jane E., Bloxham, Conor J., Chiu, Han, Chew, Keng Yih, Russell, Jake, Yoshikawa, Yusuke, Bielefeldt-Ohmann, Helle, Steele, Lauren E., Hulme, Katina D., Verzele, Nathalie A. J., Noye, Ellesandra C., Wu, Melanie, Reichelt, Melissa E., Thomas, Walter G., Gallo, Linda A., Redd, Meredith A. and Short, Kirsty R. (2021). Type I diabetes mellitus increases the cardiovascular complications of influenza virus infection. Frontiers in Cellular and Infection Microbiology, 11 714440, 714440. doi: 10.3389/fcimb.2021.714440
Cardiovascular disease in SARS‐CoV‐2 infection
Sato, Kei, Sinclair, Jane E., Sadeghirad, Habib, Fraser, John F., Short, Kirsty R. and Kulasinghe, Arutha (2021). Cardiovascular disease in SARS‐CoV‐2 infection. Clinical and Translational Immunology, 10 (9) e1343, e1343. doi: 10.1002/cti2.1343
Postnatal inflammation in ApoE−/− mice is associated with immune training and atherosclerosis
Noye, Ellesandra C., Bekkering, Siroon, Limawan, Albert P., Nguyen, Maria U., Widiasmoko, Lisa K., Lu, Hui, Pepe, Salvatore, Cheung, Michael M., Menheniott, Trevelyan R., Wallace, Megan J., Moss, Timothy J., Burgner, David P. and Short, Kirsty R. (2021). Postnatal inflammation in ApoE−/− mice is associated with immune training and atherosclerosis. Clinical Science, 135 (15), 1859-1871. doi: 10.1042/cs20210496
The role of T‐cell immunity in COVID‐19 severity amongst people living with type II diabetes
Tong, Zhen Wei Marcus, Grant, Emma, Gras, Stephanie, Wu, Melanie, Smith, Corey, Barrett, Helen L., Gallo, Linda A. and Short, Kirsty R. (2021). The role of T‐cell immunity in COVID‐19 severity amongst people living with type II diabetes. The FEBS Journal, 288 (17), 5042-5054. doi: 10.1111/febs.16105
Sinha, Roma, Ngo, Minh Dao, Bartlett, Stacey, Bielefeldt-Ohmann, Helle, Keshvari, Sahar, Hasnain, Sumaira Z., Donovan, Meg L., Kling, Jessica C., Blumenthal, Antje, Chen, Chen, Short, Kirsty R. and Ronacher, Katharina (2021). Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective. Frontiers in Cellular and Infection Microbiology, 11 691823, 691823. doi: 10.3389/fcimb.2021.691823
Lu, Jianyun, Yang, Zhicong, Karawita, Anjana C., Bunte, Myrna, Chew, Keng Yih, Pegg, Cassandra, Mackay, Ian, Whiley, David and Short, Kirsty R. (2021). Limited evidence for the role of environmental factors in the unusual peak of influenza in Brisbane during the 2018-2019 Australian summer. The Science of the Total Environment, 776 145967, 145967. doi: 10.1016/j.scitotenv.2021.145967
A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters
Zhu, Yanshan, Bloxham, Conor J., Hulme, Katina D., Sinclair, Jane E., Tong, Zhen Wei Marcus, Steele, Lauren E., Noye, Ellesandra C., Lu, Jiahai, Xia, Yao, Chew, Keng Yih, Pickering, Janessa, Gilks, Charles, Bowen, Asha C. and Short, Kirsty R. (2021). A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters. Clinical Infectious Diseases, 72 (12) ciaa1825, e1146-e1153. doi: 10.1093/cid/ciaa1825
Tong, Zhen Wei Marcus, Karawita, Anjana C., Kern, Colin, Zhou, Huaijun, Sinclair, Jane E., Yan, Limin, Chew, Keng Yih, Lowther, Sue, Trinidad, Lee, Challagulla, Arjun, Schat, Karel A., Baker, Michelle L. and Short, Kirsty R. (2021). Primary chicken and duck endothelial cells display a differential response to infection with highly pathogenic avian influenza virus. Genes, 12 (6) 901, 901. doi: 10.3390/genes12060901
Lineburg, Katie E., Grant, Emma J., Swaminathan, Srividhya, Chatzileontiadou, Demetra S.M., Szeto, Christopher, Sloane, Hannah, Panikkar, Archana, Raju, Jyothy, Crooks, Pauline, Rehan, Sweera, Nguyen, Andrea T., Lekieffre, Lea, Neller, Michelle A., Tong, Zhen Wei Marcus, Jayasinghe, Dhilshan, Chew, Keng Yih, Lobos, Christian A., Halim, Hanim, Burrows, Jacqueline M., Riboldi-Tunnicliffe, Alan, Chen, Weisan, D'Orsogna, Lloyd, Khanna, Rajiv, Short, Kirsty R., Smith, Corey and Gras, Stephanie (2021). CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses. Immunity, 54 (5), 1055-1065. doi: 10.1016/j.immuni.2021.04.006
Niazi, Sadegh, Short, Kirsty R., Groth, Robert, Cravigan, Luke, Spann, Kirsten, Ristovski, Zoran and Johnson, Graham R. (2021). Humidity-dependent survival of an airborne influenza a virus: practical implications for controlling airborne viruses. Environmental Science and Technology Letters, 8 (5), 412-418. doi: 10.1021/acs.estlett.1c00253
Sinclair, Jane E., Zhu, Yanshan, Xu, Gang, Ma, Wei, Shi, Haiyan, Ma, Kun-Long, Cao, Chun-Feng, Kong, Ling-Xi, Wan, Ke-Qiang, Liao, Juan, Wang, Hai-Qiang, Arentz, Matt, Redd, Meredith A., Gallo, Linda A. and Short, Kirsty R. (2021). A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection. iScience, 24 (4) 102264, 102264. doi: 10.1016/j.isci.2021.102264
Longmore, Danielle K., Miller, Jessica E., Bekkering, Siroon, Saner, Christoph, Mifsud, Edin, Zhu, Yanshan, Saffery, Richard, Nichol, Alistair, Colditz, Graham, Short, Kirsty R. and Burgner, David P. (2021). Diabetes and overweight/obesity are independent, nonadditive risk factors for in-hospital severity of COVID-19: an international, multicenter retrospective meta-analysis. Diabetes Care, 44 (6), dc202676-1290. doi: 10.2337/dc20-2676
Verzele, Nathalie A. J., Chua, Brendon Y., Law, Charity W., Zhang, Albert, Ritchie, Matthew E., Wightman, Oliver, Edwards, Isaac N., Hulme, Katina D., Bloxham, Conor J., Bielefeldt-Ohmann, Helle, Trewella, Matthew W., Moe, Aung Aung Kywe, Chew, Keng Yih, Mazzone, Stuart B., Short, Kirsty R. and McGovern, Alice E. (2021). The impact of influenza pulmonary infection and inflammation on vagal bronchopulmonary sensory neurons. The FASEB Journal, 35 (3) e21320, e21320. doi: 10.1096/fj.202001509r
Hulme, Katina D., Karawita, Anjana C., Pegg, Cassandra, Bunte, Myrna J. M., Bielefeldt-Ohmann, Helle, Bloxham, Conor J., Van den Hoecke, Silvie, Setoh, Yin Xiang, Vrancken, Bram, Spronken, Monique, Steele, Lauren E., Verzele, Nathalie A. J., Upton, Kyle R., Khromykh, Alexander A., Chew, Keng Yih, Sukkar, Maria, Phipps, Simon and Short, Kirsty R. (2021). A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants. eLife, 10 e61803, 1-21. doi: 10.7554/elife.61803
Pre-existing cellular immunity to SARS-CoV-2 through an immunodominant epitope
Lineburg, Katie E., Grant, Emma J., Swaminathan, Srividhya, Chatzileontiadou, Demetra S.M., Szeto, Christopher, Sloane, Hannah, Panikkar, Archana, Raju, Jyothy, Crooks, Pauline, Rehan, Sweera, Nguyen, Andrea, Lekieffre, Lea, Neller, Michelle A., Tong, Zhen Wei Marcus, Jayasinghe, Dhilshan, Chew, Keng Yih, Lobos, Christian A., Halim, Hanim, Burrows, Jacqueline M., Riboldi-Tunnicliffe, Alan, Chen, Weisan, D'Orsogna, Lloyd, Khanna, Rajiv, Short, Kirsty R., Smith, Corey and Gras, Stephanie (2021). Pre-existing cellular immunity to SARS-CoV-2 through an immunodominant epitope. SSRN Electronic Journal. doi: 10.2139/ssrn.3774361
Influenza in high-risk hosts—lessons learned from animal models
Honce, Rebekah, Wohlgemuth, Nicholas, Meliopoulos, Victoria A., Short, Kirsty R. and Schultz-Cherry, Stacey (2020). Influenza in high-risk hosts—lessons learned from animal models. Cold Spring Harbor Perspectives in Medicine, 10 (12) a038604. doi: 10.1101/cshperspect.a038604
A high fat diet increases influenza A virus-associated cardiovascular damage
Siegers, Jurre Y., Novakovic, Boris, Hulme, Katina D., Marshall, Rebecca, Bloxham, Conor J., Thomas, Walter G., Reichelt, Mellissa E., Leijten, Lonneke, van Run, Peter, Knox, Karen, Sokolowski, Kamil A., Tse, Brian W. C., Chew, Keng Yih, Christ, Angelika N., Howe, Greg, Bruxner, Timothy J. C., Karolyi, Mario, Pawelka, Erich, Koch, Rebecca M., Bellmann-Weiler, Rosa, Burkert, Francesco, Weiss, Günter, Samanta, Romit J., Openshaw, Peter J. M., Bielefeldt-Ohmann, Helle, van Riel, Debby and Short, Kirsty R. (2020). A high fat diet increases influenza A virus-associated cardiovascular damage. The Journal of infectious diseases, 222 (5), 820-831. doi: 10.1093/infdis/jiaa159
Animal and translational models of SARS-CoV-2 infection and COVID-19
Johansen, M. D., Irving, A., Montagutelli, X., Tate, M. D., Rudloff, , Nold, M. F., Hansbro, N. G., Kim, R. Y., Donovan, C., Liu, G., Faiz, A., Short, K. R., Lyons, J. G., McCaughan, G. W., Gorrell, M. D., Cole, A., Moreno, C., Couteur, D., Hesselson, D., Triccas, J., Neely, G. G., Gamble, J. R., Simpson, S. J., Saunders, B. M., Oliver, B. G., Britton, W. J., Wark, P. A., Nold-Petry, C. A. and Hansbro, P. M. (2020). Animal and translational models of SARS-CoV-2 infection and COVID-19. Mucosal Immunology, 13 (6), 877-891. doi: 10.1038/s41385-020-00340-z
Hulme, Katina Dee, Yan, Limin, Marshall, Rebecca J., Bloxham, Conor J., Upton, Kyle R., Hasnain, Sumaira Z., Bielefeldt-Ohmann, Helle, Loh, Zhixuan, Ronacher, Katharina, Chew, Keng Yih , Gallo, Linda A. and Short, Kirsty Renfree (2020). High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier. eLife, 9 e56907, 1-20. doi: 10.7554/elife.56907
Glycemic variability in diabetes increases the severity of influenza
Marshall, Rebecca J., Armart, Pornthida, Hulme, Katina D., Chew, Keng Yih, Brown, Alexandra C., Hansbro, Philip M., Bloxham, Conor J., Flint, Melanie, Ronacher, Katharina, Bielefeldt-Ohmann, Helle, Gallo, Linda A. and Short, Kirsty R. (2020). Glycemic variability in diabetes increases the severity of influenza. mBio, 11 (2) e02841-19. doi: 10.1128/mbio.02841-19
Role of endothelial cells in the pathogenesis of influenza in humans
Short, Kirsty R., Kuiken, Thijs and Van Riel, Debby (2019). Role of endothelial cells in the pathogenesis of influenza in humans. The Journal of Infectious Diseases, 220 (11), 1859-1860. doi: 10.1093/infdis/jiz349
A delicate balancing act: immunity and immunopathology in human H7N9 influenza virus infections
Karawita, Anjana C., Tong, Marcus Z. W. and Short, Kirsty R. (2019). A delicate balancing act: immunity and immunopathology in human H7N9 influenza virus infections. Current Opinion in Infectious Diseases, 32 (3), 191-195. doi: 10.1097/QCO.0000000000000538
One health insights to prevent the next HxNy viral outbreak: learning from the epidemiology of H7N9
Zheng, Zhe, Lu, Yi, Short, Kirsty R. and Lu, Jiahai (2019). One health insights to prevent the next HxNy viral outbreak: learning from the epidemiology of H7N9. BMC Infectious Diseases, 19 (1) 138, 138. doi: 10.1186/s12879-019-3752-6
Translational review: Neuroimmune mechanisms in cough and emerging therapeutic targets
McGovern, Alice E., Short, Kirsty R., Kywe Moe, Aung Aung and Mazzone, Stuart B. (2018). Translational review: Neuroimmune mechanisms in cough and emerging therapeutic targets. Journal of Allergy and Clinical Immunology, 142 (5), 1392-1402. doi: 10.1016/j.jaci.2018.09.004
The culture of primary duck endothelial cells for the study of avian influenza
Davis, Raissa L., Choi, Geunho, Kuiken, Thijs, Quéré, Pascale, Trapp, Sascha, Short, Kirsty R. and Richard, Mathilde (2018). The culture of primary duck endothelial cells for the study of avian influenza. BMC Microbiology, 18 (1) 138, 138. doi: 10.1186/s12866-018-1307-4
Creating disease resistant chickens: a viable solution to avian influenza?
Looi, Fong Yang, Baker, Michelle L., Townson, Thomas, Richard, Mathilde, Novak, Ben, Doran, Tim J. and Short, Kirsty R. (2018). Creating disease resistant chickens: a viable solution to avian influenza?. Viruses, 10 (10) 561, 561. doi: 10.3390/v10100561
Back to the future: lessons learned from the 1918 influenza pandemic
Short, Kirsty R., Kedzierska, Katherine and van de Sandt, Carolien E. (2018). Back to the future: lessons learned from the 1918 influenza pandemic. Frontiers in Cellular and Infection Microbiology, 8 343, 343. doi: 10.3389/fcimb.2018.00343
Lion, Adrien, Richard, Mathilde, Esnault, Evelyne, Kut, Emmanuel, Soubieux, Denis, Guillory, Vanaïque, Germond, Mélody, Blondeau, Caroline, Guabiraba, Rodrigo, Short, Kirsty R., Marc, Daniel, Quéré, Pascale and Trapp, Sascha (2017). Productive replication of avian influenza viruses in chicken endothelial cells is determined by hemagglutinin cleavability and is related to innate immune escape. Virology, 513, 29-42. doi: 10.1016/j.virol.2017.10.007
Proinflammatory Cytokine Responses in Extra-Respiratory Tissues During Severe Influenza
Short, Kirsty R., Veeris, Rebecca, Leijten, Lonneke M., van den Brand, Judith M., Jong, Victor L., Stittelaar, Koert, Osterhaus, Ab D. M. E., Andeweg, Arno and van Riel, Debby (2017). Proinflammatory Cytokine Responses in Extra-Respiratory Tissues During Severe Influenza. The Journal of Infectious Diseases, 216 (7), 829-833. doi: 10.1093/infdis/jix281
Influenza virus and glycemic variability in diabetes: a killer combination?
Hulme, Katina D., Gallo, Linda A. and Short, Kirsty R. (2017). Influenza virus and glycemic variability in diabetes: a killer combination?. Frontiers in Microbiology, 8 (MAY) 861, 861. doi: 10.3389/fmicb.2017.00861
RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma
Arikkatt, Jaisy, Ullah, Md Ashik, Short, Kirsty Renfree, Zhang, Vivian, Gan, Wan Jun, Loh, Zhixuan, Werder, Rhiannon B., Simpson, Jennifer, Sly, Peter D., Mazzone, Stuart B., Spann, Kirsten M., Ferreira, Manuel A R., Upham, John W., Sukkar, Maria B. and Phipps, Simon (2017). RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma. eLife, 6 e21199. doi: 10.7554/eLife.21199
Human CD8(+) T Cells Damage Noninfected Epithelial Cells during Influenza Virus Infection In Vitro
Van De Sandt, Carolien E., Barcena, Montserrat, Koster, Abraham J., Kasper, Jennifer, Kirkpatrick, Charles J., Scott, Dana P., De Vries, Rory D., Herold, Susanne, Rimmelzwaan, Guus F., Kuiken, Thijs and Short, Kirsty R. (2016). Human CD8(+) T Cells Damage Noninfected Epithelial Cells during Influenza Virus Infection In Vitro. American Journal of Respiratory Cell and Molecular Biology, 57 (5), 536-546. doi: 10.1165/rcmb.2016-0377OC
Job, Emma R., Pizzolla, Angela, Nebl, Thomas, Short, Kirsty R., Deng, Yi-Mo, Carolan, Louise, Laurie, Karen L., Brooks, Andrew G. and Reading, Patrick C. (2016). Neutralising inhibitors in the airways of naïve ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses. Virology, 494, 143-157. doi: 10.1016/j.virol.2016.01.024
Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions
Short, Kirsty R., Kasper, Jennifer, van der Aa, Stijn, Andeweg, Arno C., Zaaraoui-Boutahar, Fatiha, Goeijenbier, Marco, Richard, Mathilde, Herold, Susanne, Becker, Christin, Scott, Dana P., Limpens, Ronald W. A. L., Koster, Abraham J., Bárcena, Montserrat, Fouchier, Ron A. M., Kirkpatrick, Charles James and Kuiken, Thijs (2016). Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions. European Respiratory Journal, 47 (3), 954-966. doi: 10.1183/13993003.01282-2015
Reducing the impact of influenza-associated secondary pneumococcal infections
Mifsud, Edin J., Tan, Amabel C., Short, Kirsty R., Brown, Lorena E., Chua, Brendon Y. and Jackson, David C. (2016). Reducing the impact of influenza-associated secondary pneumococcal infections. Immunology and Cell Biology, 94 (1), 101-108. doi: 10.1038/icb.2015.71
One health, multiple challenges: the inter-species transmission of influenza A virus
Short, Kirsty R., Richard, Mathilde, Verhagen, Josanne H., van Riel, Debby, Schrauwen, Eefje J. A., van den Brand, Judith M. A., Manz, Benjamin, Bodewes, Rogier and Herfst, Sander (2015). One health, multiple challenges: the inter-species transmission of influenza A virus. One Health, 1, 1-13. doi: 10.1016/j.onehlt.2015.03.001
Spronken, Monique I., Short, Kirsty R., Herfst, Sander, Bestebroer, Theo M., Vaes, Vincent P., van der Hoeven, Barbara, Koster, Abraham J., Kremers, Gert-Jan, Scott, Dana P., Gultyaev, Alexander P., Sorell, Erin M., de Graaf, Miranda, Barcena, Montserrat, Rimmelzwaan, Guus F. and Fouchier, Ron A. (2015). Optimisations and Challenges Involved in the Creation of Various Bioluminescent and Fluorescent Influenza A Virus Strains for In Vitro and In Vivo Applications. PLoS One, 10 (8) e0133888, e0133888-e0133888. doi: 10.1371/journal.pone.0133888
Chua, Brendon Y., Sekiya, Toshiki, Al Kobaisi, Mohammad, Short, Kirsty R., Mainwaring, David E. and Jackson, David C. (2015). A single dose biodegradable vaccine depot that induces persistently high levels of antibody over a year. Biomaterials, 53, 50-57. doi: 10.1016/j.biomaterials.2015.02.066
Londrigan, Sarah L., Short, Kirsty R., Ma, Joel, Gillespie, Leah, Rockman, Steven P., Brooks, Andrew G. and Reading, Patrick C. (2015). Infection of mouse macrophages by seasonal influenza viruses can be restricted at the level of virus entry and at a late stage in the virus life cycle. Journal of Virology, 89 (24), 12319-12329. doi: 10.1128/JVI.01455-15
Influenza virus and endothelial cells: a species specific relationship
Short, Kirsty R., Kroeze, Edwin J. B. Veldhuis, Reperant, Leslie A., Richard, Mathilde and Kuiken, Thijs (2014). Influenza virus and endothelial cells: a species specific relationship. Frontiers in Microbiology, 5 (DEC) 653, 653.1-653.11. doi: 10.3389/fmicb.2014.00653
Short, Kirsty R., Vissers, Marloes, De Kleijn, Stan, Zomer, Aldert L., Kedzierska, Katherine, Grant, Emma, Reading, Patrick C., Hermans, Peter W. M., Ferwerda, Gerben and Diavatopoulos, Dimitri A. (2014). Bacterial lipopolysaccharide inhibits influenza virus infection of human macrophages and the consequent induction of cd8+ t cell immunity. Journal of Innate Immunity, 6 (2), 129-139. doi: 10.1159/000353905
Siegers, Jurre Y., Short, Kirsty R., Leijten, Lonneke M. E., de Graaf, Miranda, Spronken, Monique I. J., Schrauwen, Eefje J. A., Marshall, Nicolle, Lowen, Anice C., Gabriel, Gülsah, Osterhaus, Albert D. M. E., Kuiken, Thijs and van Riel, Debby (2014). Novel avian-origin influenza A (H7N9) virus attachment to the respiratory tract of five animal models. Journal of Virology, 88 (8), 4595-4599. doi: 10.1128/JVI.03190-13
Job, Emma R., Bottazzi, Barbara, Short, Kirsty R., Deng, Yi-Mo, Mantovani, Alberto, Brooks, Andrew G. and Reading, Patrick C. (2014). A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice. The Journal of Immunology, 192 (1), 271-281. doi: 10.4049/jimmunol.1301814
Short, Kirsty R., von Köckritz-Blickwede, Maren, Langereis, Jeroen D., Chew, Keng Yih, Job, Emma R., Armitage, Charles W., Hatcher, Brandon, Fujihashi, Kohtaro, Reading, Patrick C., Hermans, Peter W., Wijburg, Odilia L. and Diavatopoulos, Dimitri A. (2014). Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media. Infection and Immunity, 82 (1), 364-370. doi: 10.1128/IAI.01104-13
Pathogenesis of influenza-induced acute respiratory distress syndrome
Short, Kirsty R., Kroeze, Edwin J. B. Veldhuis, Fouchier, Ron A. M. and Kuiken, Thijs (2014). Pathogenesis of influenza-induced acute respiratory distress syndrome. Lancet Infectious Diseases, 14 (1), 57-69. doi: 10.1016/S1473-3099(13)70286-X
Short, Kirsty R., Grant, Emma J., Vissers, Marloes, Reading, Patrick C., Diavatopoulos, Dimitri A. and Kedzierska, Katherine (2013). A novel method linking antigen presentation by human monocyte-derived macrophages to CD8(+) T cell polyfunctionality. Frontiers in Immunology, 4 (389) Article 389, 1-7. doi: 10.3389/fimmu.2013.00389
van Riel, Debby, Leijten, Lonneke M. E., de Graaf, Miranda, Siegers, Jurre Y., Short, Kirsty R., Spronken, Monique I. J., Schrauwen, Eefje J. A., Fouchier, Ron A. M., Osterhaus, Albert D. M. E. and Kuiken, Thijs (2013). Novel avian-origin influenza A (H7N9) virus attaches to epithelium in both upper and lower respiratory tract of humans. American Journal of Pathology, 183 (4), 1137-1143. doi: 10.1016/j.ajpath.2013.06.011
Short, Kirsty R., Habets, Marrit N., Payne, Jean., Reading, Patrick C., Diavatopoulos, Dimitri A. and Wijburg, Odilia L. (2013). Influenza A virus induced bacterial otitis media is independent of virus tropism for α2,6-linked sialic acid. Virology Journal, 10 (1) 128. doi: 10.1186/1743-422X-10-128
Influenza-induced inflammation drives pneumococcal otitis media
Short, Kirsty R., Reading, Patrick C., Brown, Lorena E., Pedersen, John, Gilbertson, Brad, Job, Emma R., Edenborough, Kathryn M., Habets, Marrit N., Zomer, Aldert, Hermans, Peter W. M., Diavatopoulos, Dimitri A. and Wijburg, Odilia L. (2013). Influenza-induced inflammation drives pneumococcal otitis media. Infection and Immunity, 81 (3), 645-652. doi: 10.1128/IAI.01278-12
The fate of influenza A virus after infection of human macrophages and dendritic cells
Short, Kirsty R., Brooks, Andrew G., Reading, Patrick C. and Londrigan, Sarah L. (2012). The fate of influenza A virus after infection of human macrophages and dendritic cells. Journal of General Virology, 93 (PART 11), 2315-2325. doi: 10.1099/vir.0.045021-0
Short, Kirsty R., Habets, Marrit N., Hermans, Peter W. M. and Diavatopoulos, Dimitri A. (2012). Interactions between Streptococcus pneumoniae and influenza virus: a mutually beneficial relationship?. Future Microbiology, 7 (5), 609-624. doi: 10.2217/fmb.12.29
NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells
Kupz, Andreas, Guarda, Greta, Gebhardt, Thomas, Sander, Leif E., Short, Kirsty R., Diavatopoulos, Dimitri A., Wijburg, Odilia L. C., Cao, Hanwei, Waithman, Jason C., Chen, Weisan, Fernandez-Ruiz, Daniel, Whitney, Paul G., Heath, William R., Curtiss, Roy, Tschopp, Jürg, Strugnell, Richard A. and Bedoui, Sammy (2012). NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells. Nature Immunology, 13 (2), 162-169. doi: 10.1038/ni.2195
Short, Kirsty R., Reading, Patrick C., Wang, Nancy, Diavatopoulos, Dimitri A. and Wijburg, Odilia L. (2012). Increased nasopharyngeal bacterial titers and local inflammation facilitate transmission of Streptococcus pneumoniae. mBio, 3 (5) e00255-12. doi: 10.1128/mBio.00255-12
Influenza virus induces bacterial and nonbacterial otitis media
Short, Kirsty R., Diavatopoulos, Dimitri A., Thornton, Ruth, Pedersen, John, Strugnell, Richard A., Wise, Andrew K., Reading, Patrick C. and Wijburg, Odilia L. (2011). Influenza virus induces bacterial and nonbacterial otitis media. Journal of Infectious Diseases, 204 (12), 1857-1865. doi: 10.1093/infdis/jir618
Wang, Jianghui, Wong, Emily S. W., Whitely, Jane C., Li, Jian, Stringer, Jessica M., Short, Kirsty R., Renfree, Marilyn B., Belov, Katherine and Cocks, Benjamin G. (2011). Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options. PLoS One, 6 (8) e24030, e24030.1-e24030.8. doi: 10.1371/journal.pone.0024030
Wilksch, Jonathan J., Yang, Ji, Clements, Abigail, Gabbe, Jacinta L., Short, Kirsty R., Cao, Hanwei, Cavaliere, Rosalia, James, Catherine E., Whitchurch, Cynthia B., Schembri, Mark A., Chuah, Mary L. C., Liang, Zhao-Xun, Wijburg, Odilia L., Jenney, Adam W., Lithgow, Trevor and Strugnell, Richard A. (2011). MrkH, a novel c-di-GMP-dependent transcriptional activator, controls Klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression. PloS Pathogens, 7 (8) e1002204, e1002204. doi: 10.1371/journal.ppat.1002204
Renfree, Marilyn B., Papenfuss, Anthony T., Deakin, Janine E., Lindsay, James, Heider, Thomas, Belov, Katherine, Rens, Willem, Waters, Paul D., Pharo, Elizabeth A., Shaw, Geoff, Wong, Emily S. W., Lefevre, Christopher M., Nicholas, Kevin R., Kuroki, Yoko, Wakefield, Matthew J., Zenger, Kyall R., Wang, Chenwei, Ferguson-Smith, Malcolm, Nicholas, Frank W., Hickford, Danielle, Yu, Hongshi, Short, Kirsty R., Siddle, Hannah V., Frankenberg, Stephen R., Chew, Keng Yih, Menzies, Brandon R., Stringer, Jessica M., Suzuki, Shunsuke, Hore, Timothy A. ... Worley, Kim C. (2011). Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biology, 12 (8) R81, R81.1-R81.25. doi: 10.1186/gb-2011-12-8-r81
Renfree, MB, Papenfuss, AT, Deakin, JE, Lindsay, J, Heider, T, Belov, K, Rens, W, Waters, PD, Pharo, EA, Shaw, G, Wong, ESW, Lefevre, CM, Nicholas, KR, Kuroki, Y, Wakefield, MJ, Zenger, KR, Wang, CW, Ferguson-Smith, M, Nicholas, FW, Hickford, D, Yu, HS, Short, KR, Siddle, HV, Frankenberg, SR, Chew, KY, Menzies, BR, Stringer, JM, Suzuki, S, Hore, TA ... Worley, KC (2011). Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development (vol 12, pg R81, 2011). Genome Biology, 12 (12) 414. doi: 10.1186/gb-2011-12-12-414
Short, Kirsty R., Diavatopoulos, Dimitri A., Reading, Patrick C., Brown, Lorena E., Rogers, Kelly L., Strugnell, Richard A. and Wijburg, Odilia L C (2011). Using bioluminescent imaging to investigate synergism between Streptococcus pneumoniae and influenza A virus in infant mice. Journal of Visualized Experiments (50) e2357. doi: 10.3791/2357
Influenza A virus facilitates Streptococcus pneumoniae transmission and disease
Diavatopoulos, Dimitri A., Short, Kirsty R., Price, John T., Wilksch, Jonathan J., Brown, Lorena E., Briles, David E., Strugnell, Richard A. and Wijburg, Odilia L. (2010). Influenza A virus facilitates Streptococcus pneumoniae transmission and disease. FASEB Journal, 24 (6), 1789-1798. doi: 10.1096/fj.09-146779
Wagner, Josef, Short, Kirsty, Catto-Smith, Anthony G., Cameron, Don J. S., Bishop, Ruth F. and Kirkwood, Carl D. (2008). Identification and Characterisation of Pseudomonas 16S Ribosomal DNA from Ileal Biopsies of Children with Crohn's Disease. PLoS ONE, 3 (10) e0003578, e3578. doi: 10.1371/journal.pone.0003578
Karawita, Anjana, Short, Kirsty and Karawita, Anjana Chamal (2021). Mute swan ISOseq data. The University of Queensland. (Dataset) doi: 10.48610/afb4f31
(2022–2026) NHMRC Investigator Grants
An integrated analytical network for protein characterisation
(2022–2023) ARC Linkage Infrastructure, Equipment and Facilities
Harnessing Oxidised Cholesterols to Reduce Susceptibility to COVID-19 in Obesity and Diabetes
(2022) Diabetes Australia Research Program
Queensland CoViD-19 Vaccination (QoVAX SET) Safety and Efficacy Trial ¿ Mixed Dose 1 and 2 Study
(2022) Metro North Hospital and Health Service
(2021–2024) Queensland University of Technology
The immunological legacy of obesity on viral pathogenesis
(2021–2023) NHMRC IDEAS Grants
Protecting Australia's Poultry using genetic restoration
(2021–2022) Australian Eggs Limited
QoVAX SET Program - Neutralisation Assays
(2021–2022) Queensland Health
Challenge experiments - an immunisation regime with peptides
(2021) James Cook University
(2020–2022) Queensland Institute of Medical Research
Neuro-immune cross talk in influenza virus pathogenesis
(2019–2021) NHMRC Project Grant
The role of glycaemic variability in influenza virus pathogenesis and immunity
(2019–2021) NHMRC Project Grant
Using comparative genomics to prevent avian influenza in poultry
(2019–2020) Commonwealth Department of Agriculture and Water Resources
Blocking the nervous system: a new approach for treating severe influenza?
(2019) UQ Foundation Research Excellence Awards
In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
(2019) UQ Major Equipment and Infrastructure
Bird flu in avian species: understanding the mechanisms of disease
(2018–2021) ARC Discovery Early Career Researcher Award
Natural resistance to avian influenza: a novel approach for improving biosecurity
(2018–2019) Commonwealth Department of Agriculture and Water Resources
(2018) UQ Major Equipment and Infrastructure
Preventing severe influenza in people with diabetes
(2018) Diabetes Australia Research Trust
The role of asthma in the generation of influenza virus quasispecies
(2017–2018) UQ Development Fellowships
The role of HMGB1 in the severity of influenza virus infection in asthmatic individuals
(2016–2017) UQ Early Career Researcher
(2013–2017) NHMRC Training (Postdoctoral) Fellowship
The Role of Host Co-morbidities in Influenza Severity
Doctor Philosophy — Principal Advisor
Other advisors:
Genesis and Pathognesis of avain influenza
Doctor Philosophy — Principal Advisor
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Avian Genomics and Transcriptomics to understand the Pathogenesis of Highly Pathogenic Avian Influenza Virus in Black Swans
Doctor Philosophy — Principal Advisor
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The long-term cardiovascular complications of COVID-19
Doctor Philosophy — Principal Advisor
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A new treatment for viral disease: Modulators of the renin angiotension system
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THE IMMUNOLOGICAL LEGACY OF OBESITY ON VIRAL PATHOGENESIS
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Neurological control of respiratory inflammation
Doctor Philosophy — Principal Advisor
Predict & Prevent: Stopping the next influenza virus pandemic
Doctor Philosophy — Principal Advisor
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Understanding the interaction between diabetes and severe influenza
Doctor Philosophy — Principal Advisor
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Investigating how antibodies against Influenza A Virus modulate macrophage sensing and signalling pathways and outputs.
Doctor Philosophy — Associate Advisor
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Know your enemy: How our innate immune system detects influenza virus infection
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Pathogen-Exploited and Host-Defense G Protein-Coupled Receptors During Bacterial and Viral Infections
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