Journal Article: Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene
Irvine, Katharine M., Caruso, Melanie, Cestari, Michelle Ferrari, Davis, Gemma M., Keshvari, Sahar, Sehgal, Anuj, Pridans, Clare and Hume, David A. (2019) Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene. Journal of Leukocyte Biology, . doi:10.1002/jlb.ma0519-149r
Journal Article: Clinically significant fibrosis is associated with longitudinal increases in fibrosis-4 and nonalcoholic fatty liver disease fibrosis scores
Janubhai Patel, Preya, Chieh-Yu Cheng, Johnson, Banh, Xuan, Gracen, Lucy, Radford-Smith, Daniel, Hossain, Fabrina, Horsfall, Leigh Ula, Lee Hayward, Kelly, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Stuart, Katherine Anne, Russell, Anthony William, Valery, Patricia Casarolli, Clouston, Andrew Donald, Irvine, Katharine Margaret, Bernard, Anne and Powell, Elizabeth Ellen (2019) Clinically significant fibrosis is associated with longitudinal increases in fibrosis-4 and nonalcoholic fatty liver disease fibrosis scores. Clinical Gastroenterology and Hepatology, . doi:10.1016/j.cgh.2019.07.036
Journal Article: Phenotypic impacts of CSF1R deficiencies in humans and model organisms
Hume, David A., Caruso, Melanie, Ferrari‐Cestari, Michelle, Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2019) Phenotypic impacts of CSF1R deficiencies in humans and model organisms. Journal of Leukocyte Biology, . doi:10.1002/jlb.mr0519-143r
CSF1 Therapy for Chronic Liver Disease
(2019–2021) NHMRC Project Grant
(2019–2020) Mater Foundation
Serum biomarkers for risk stratification in nonalcoholic fatty liver disease
(2015–2017) Siemens Ltd
Targeting Peritoneal immunity to improve outcomes in patients with cirrhosis and ascites
Master Philosophy
The impacts of Csf1r insufficiency on microglia and brain development
Doctor Philosophy
(2019) Doctor Philosophy
The impact of CAGE data on understanding macrophage transcriptional biology
Hume, David A., Schroder, Kate and Irvine, Katharine M. (2009). The impact of CAGE data on understanding macrophage transcriptional biology. In Cap-Analysis Gene Expression (CAGE): The Science of Decoding Genes Transcription (pp. 227-243) : Pan Stanford Publishing Pte. Ltd.. doi:10.4032/9789814241359
The impact of CAGE data on the understanding of macrophage transcriptional biology
Hume, D. A., Irvine, K. M. and Schroder, K. (2009). The impact of CAGE data on the understanding of macrophage transcriptional biology. In Piero Carninci (Ed.), Cap- Analysis Gene Expression (Cage): The Science of Decoding Gene Transcription (pp. 227-244) Singapore: Pan Stanford Publishing.
Irvine, Katharine M., Caruso, Melanie, Cestari, Michelle Ferrari, Davis, Gemma M., Keshvari, Sahar, Sehgal, Anuj, Pridans, Clare and Hume, David A. (2019) Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene. Journal of Leukocyte Biology, . doi:10.1002/jlb.ma0519-149r
Janubhai Patel, Preya, Chieh-Yu Cheng, Johnson, Banh, Xuan, Gracen, Lucy, Radford-Smith, Daniel, Hossain, Fabrina, Horsfall, Leigh Ula, Lee Hayward, Kelly, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Stuart, Katherine Anne, Russell, Anthony William, Valery, Patricia Casarolli, Clouston, Andrew Donald, Irvine, Katharine Margaret, Bernard, Anne and Powell, Elizabeth Ellen (2019) Clinically significant fibrosis is associated with longitudinal increases in fibrosis-4 and nonalcoholic fatty liver disease fibrosis scores. Clinical Gastroenterology and Hepatology, . doi:10.1016/j.cgh.2019.07.036
Phenotypic impacts of CSF1R deficiencies in humans and model organisms
Hume, David A., Caruso, Melanie, Ferrari‐Cestari, Michelle, Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2019) Phenotypic impacts of CSF1R deficiencies in humans and model organisms. Journal of Leukocyte Biology, . doi:10.1002/jlb.mr0519-143r
Hayward, Kelly L., Valery, Patricia C., Cottrell, W. Neil, Irvine, Katharine M., Martin, Jennifer H. and Powell, Elizabeth E. (2019) Reply. Hepatology Communications, 3 9: 1283-1284. doi:10.1002/hep4.1398
Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Gupta, Praveer K., Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2019) Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation. British Journal of Pharmacology, 176 19: 3775-3790. doi:10.1111/bph.14768
Genz, Berit, Coleman, Miranda A., Irvine, Katharine M., Kutasovic, Jamie R., Miranda, Mariska, Gratte, Francis D., Tirnitz-Parker, Janina E. E., Olynyk, John. K., Calvopina, Diego A., Weis, Anna, Cloonan, Nicole, Robinson, Harley, Hill, Michelle M., Al-Ejeh, Fares and Ramm, Grant A. (2019) Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells. Scientific Reports, 9 1: 8541. doi:10.1038/s41598-019-44865-1
Hayward, Kelly L., Patel, Preya J., Valery, Patricia C., Horsfall, Leigh U., Li, Catherine Y., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., Irvine, Katharine M., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2019) Medication‐related problems in outpatients with decompensated cirrhosis: Opportunities for harm prevention. Hepatology Communications, . doi:10.1002/hep4.1334
Causes and consequences of innate immune dysfunction in cirrhosis
Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019) Causes and consequences of innate immune dysfunction in cirrhosis. Frontiers in Immunology, 10 . doi:10.3389/fimmu.2019.00293
The mononuclear phagocyte system: the relationship between monocytes and macrophages
Hume, David A., Irvine, Katharine M. and Pridans, Clare (2019) The mononuclear phagocyte system: the relationship between monocytes and macrophages. Trends in Immunology, 40 2: 98-112. doi:10.1016/j.it.2018.11.007
Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019) Corrigendum: Causes and consequences of innate immune dysfunction in cirrhosis (Frontiers in Immunology (2019) 10 (293) DOI: 10.3389/fimmu.2019.00293). Frontiers in Immunology, 10 APR: 818. doi:10.3389/fimmu.2019.00818
ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages
Waddell, Lindsey A., Lefevre, Lucas, Bush, Stephen J., Raper, Anna, Young, Rachel, Lisowski, Zofia M., McCulloch, Mary E.B., Muriuki, Charity, Sauter, Kristin A., Clark, Emily L., Irvine, Katharine M., Pridans, Clare, Hope, Jayne C. and Hume, David A. (2018) ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages. Frontiers in Immunology, 9 OCT: . doi:10.3389/fimmu.2018.02246
Patel, Preya Janubhai, Hossain, Fabrina, Horsfall, Leigh Ula, Banh, Xuan, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Bernard, Anne, Brown, Nigel Neil, Lampe, Guy, Buck, Lyndall, Saad, Nivene, Russell, Anthony William, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Clouston, Andrew Donald, Stuart, Katherine Anne, Rosenberg, William and Powell, Elizabeth Ellen (2018) A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care. Hepatology Communications, 2 8: 893-905. doi:10.1002/hep4.1208
Ramnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018) Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 14: . doi:10.1172/jci.insight.120274
Patel, Preya Janubhai, Hossain, Fabrina, Horsfall, Leigh Ula, Banh, Xuan, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Clouston, Andrew Donald, Stuart, Katherine Anne, Russell, Anthony William and Powell, Elizabeth Ellen (2018) Controlled attenuation parameter in NAFLD identifies risk of suboptimal glycaemic and metabolic control. Journal of Diabetes and its Complications, 32 8: 799-804. doi:10.1016/j.jdiacomp.2018.05.008
Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E. and Sweet, M. (2018) RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease. Journal of Hepatology, 68 S1: S401-S402. doi:10.1016/s0168-8278(18)31040-7
Pridans, Clare, Sauter, Kristin A., Irvine, Katharine M., Davis, Gemma M., Lefevre, Lucas, Raper, Anna, Rojo, Rocio, Nirmal, Ajit J., Beard, Philippa, Cheeseman, Michael and Hume, David A. (2018) Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314 3: G388-G398. doi:10.1152/ajpgi.00343.2017
Maradana, Muralidhara Rao, Yekollu, Suman Kumar, Zeng, Bijun, Ellis, Jonathan, Clouston, Andrew, Miller, Gregory, Talekar, Meghna, Bhuyan, Zaied Ahmed, Mahadevaiah, Sachin, Powell, Elizabeth E., Irvine, Katharine M., Thomas, Ranjeny and O'Sullivan, Brendan John (2018) Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism: Clinical and Experimental, 78 80-94. doi:10.1016/j.metabol.2017.09.002
Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease
Patel, Preya J., Smith, David, Connor, Jason P., Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew D., Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C. and Powell, Elizabeth E. (2017) Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease. Canadian Journal of Gastroenterology and Hepatology, 2017 7927685-8. doi:10.1155/2017/7927685
Patel, Preya J., Banh, Xuan, Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew, Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C., Williams, Suzanne and Powell, Elizabeth E (2017) Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis. Internal Medicine Journal, 48 2: 144-151. doi:10.1111/imj.13667
Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis
Hayward, Kelly L., Valery, Patricia C., Martin, Jennifer H., Karmakar, Antara, Patel, Preya J., Horsfall, Leigh U., Tallis, Caroline J., Stuart, Katherine A., Wright, Penny L., Smith, David D., Irvine, Katharine M., Powell, Elizabeth E. and Cottrell, W. Neil (2017) Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis. World Journal of Gastroenterology, 23 40: 7321-7331. doi:10.3748/wjg.v23.i40.7321
Hayward, Kelly L., Horsfall, Leigh U., Ruffin, Brittany J., Cottrell, W. Neil, Chachay, Veronique S., Irvine, Katharine M., Martin, Jennifer H., Powell, Elizabeth E. and Valery, Patricia C. (2017) Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management. Internal Medicine Journal, 47 8: 952-955. doi:10.1111/imj.13505
Hayward, Kelly L., Martin, Jennifer H., Cottrell, W. Neil, Karmakar, Antara, Horsfall, Leigh U., Patel, Preya J., Smith, David D., Irvine, Katharine M., Powell, Elizabeth E. and Valery, Patricia C. (2017) Patient-oriented education and medication management intervention for people with decompensated cirrhosis: study protocol for a randomized controlled trial. Trials, 18 1: 339. doi:10.1186/s13063-017-2075-4
Patel, Preya Janubhai, Hayward, Kelly Lee, Rudra, Rathiga, Horsfall, Leigh Ula, Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Clouston, Andrew Donald, Stuart, Katherine Anne, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Russell, Anthony William and Powell, Elizabeth Ellen (2017) Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management. Medicine, 96 26: e6761. doi:10.1097/MD.0000000000006761
O'Leary, Caroline A., Sedhom, Mamdouh, Reeve-Johnson, Mia, Mallyon, John and Irvine, Katharine M. (2017) Expression profiling feline peripheral blood monocytes identifies a transcriptional signature associated with type two diabetes mellitus. Veterinary Immunology and Immunopathology, 186 1-8. doi:10.1016/j.vetimm.2016.12.011
El-Atem, Nathan, Irvine, Katharine M., Valery, Patricia C., Wojcik, Kyle, Horsfall, Leigh, Johnson, Tracey, Janda, Monika, McPhail, Steven M. and Powell, Elizabeth E. (2017) Identifying areas of need relative to liver disease: geographic clustering within a health service district. Australian Health Review, 41 4: 407-418. doi:10.1071/AH15225
Irvine, Katharine M., Wockner, Leesa F., Hoffmann, Isabel, Horsfall, Leigh U., Fagan, Kevin J., Bijin, Veonice, Lee, Bernett, Clouston, Andrew D., Lampe, Guy, Connolly, John E. and Powell, Elizabeth E. (2016) Multiplex serum protein analysis identifies novel biomarkers of advanced fibrosis in patients with chronic liver disease with the potential to improve diagnostic accuracy of established biomarkers. PLoS ONE, 11 11: e0167001. doi:10.1371/journal.pone.0167001
Prevalence of medication discrepancies in patients with cirrhosis: A pilot study
Hayward, Kelly L., Valery, Patricia C., Cottrell, W. Neil, Irvine, Katharine M., Horsfall, Leigh U., Tallis, Caroline J., Chachay, Veronique S., Ruffin, Brittany J., Martin, Jennifer H. and Powell, Elizabeth E. (2016) Prevalence of medication discrepancies in patients with cirrhosis: A pilot study. BMC Gastroenterology, 16 1: 114. doi:10.1186/s12876-016-0530-4
Gadd, Victoria L., Patel, Preya J., Jose, Sara, Horsfall, Leigh, Powell, Elizabeth E. and Irvine, Katharine M. (2016) Altered peripheral blood monocyte phenotype and function in chronic liver disease: implications for hepatic recruitment and systemic inflammation. PLoS One, 11 6: e0157771. doi:10.1371/journal.pone.0157771
Irvine, Katharine M., Xuan Banh, Gadd, Victoria L., Wojcik, Kyle K., Ariffin, Juliana K., Jose, Sara, Lukowski, Samuel, Baillie, Gregory J., Sweet, Matthew J. and Powell, Elizabeth E. (2016) CRIg-expressing peritoneal macrophages are associated with disease severity in patients with cirrhosis and ascites. JCI Insight, 1 8: e86914. doi:10.1172/jci.insight.86914
El-Atem, N. A., Wojcik, K., Horsfall, L., Irvine, K. M., Johnson, T., McPhail, S. M. and Powell, E. E. (2016) Patterns of service utilisation within Australian hepatology clinics: high prevalence of advanced liver disease. Internal Medicine Journal, 46 4: 420-426. doi:10.1111/imj.13008
Melino, Michelle, Gadd, Victoria L., Alexander, Kylie A., Beattie, Lynette, Lineburg, Katie E., Martinez, Michelle, Teal, Bianca, Le Texier, Laetitia, Irvine, Katharine M., Miller, Gregory C., Boyle, Glen M., Hill, Geoffrey R., Clouston, Andrew D., Powel, Elizabeth E. and MacDonald, Kelli P. A. (2016) Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model. American Journal of Pathology, 186 3: 524-538. doi:10.1016/j.ajpath.2015.10.029
Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016) Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 5: 1901-1912. doi:10.1096/fj.201500061
Can paracetamol (acetaminophen) be administered to patients with liver impairment?
Hayward, Kelly L., Powell, Elizabeth E., Irvine, Katharine M. and Martin, Jennifer H. (2015) Can paracetamol (acetaminophen) be administered to patients with liver impairment?. British Journal of Clinical Pharmacology, 81 2: 210-222. doi:10.1111/bcp.12802
Irvine, Katharine M., Clouston, Andrew D., Gadd, Victoria L., Miller, Gregory C., Wong, Weng-Yew, Melino, Michelle, Maradana, Muralidhara Rao, MacDonald, Kelli, Lang, Richard A., Sweet, Matthew J., Blumenthal, Antje and Powell, Elizabeth E. (2015) Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury. Fibrogenesis and Tissue Repair, 8 19: 19. doi:10.1186/s13069-015-0036-7
Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes
Pang, Dimeng, Irvine, Katharine M., Mehdi, Ahmed M., Thomas, Helen E., Harris, Mark, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2015) Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clinical and Translational Immunology, 4 8: e41.1-e41.9. doi:10.1038/cti.2015.17
Irvine, Katharine M., Wockner, Leesa F., Shanker, Mihir, Fagan, Kevin J., Horsfall, Leigh U., Fletcher, Linda M., Ungerer, Jacobus P. J., Pretorius, Carel J., Miller, Gregory C., Clouston, Andrew D., Lampe, Guy and Powell, Elizabeth E. (2015) The Enhanced liver fibrosis score is associated with clinical outcomes and disease progression in patients with chronic liver disease. Liver International, 36 3: 370-377. doi:10.1111/liv.12896
Response to ELF cut-off points: aetiology is also a relevant factor
Powell, Elizabeth E., Irvine, Katharine M., Fagan, Kevin J., Ballard, Emma and O'Rourke, Peter (2015) Response to ELF cut-off points: aetiology is also a relevant factor. Liver International, 35 7: 1921-1921. doi:10.1111/liv.12822
Fagan, Kevin J., Pretorius, Carel J., Horsfall, Leigh U., Irvine, Katharine M., Wilgen, Urs, Choi, Kihoon, Fletcher, Linda M., Tate, Jill, Melino, Michelle, Nusrat, Sharmin, Miller, Gregory C., Clouston, Andrew D., Ballard, Emma, O'Rourke, Peter, Lampe, Guy, Ungerer, Jacobus P. J. and Powell, Elizabeth E. (2015) ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity. Liver International, 35 6: 1673-1681. doi:10.1111/liv.12760
Fagan, Kevin J., Rogers, Geraint B., Melino, Michelle, Arthur, Dionne M., Costello, Mary-Ellen, Morrison, Mark, Powell, Elizabeth E. and Irvine, Katharine M. (2015) Ascites bacterial burden and immune cell profile are associated with poor clinical outcomes in the absence of overt infection. PLoS One, 10 3: e0120642. doi:10.1371/journal.pone.0120642
Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration
Irvine, Katharine M., Skoien, Richard, Bokil, Nilesh J., Melino, Michelle, Thomas, Gethin P., Loo, Dorothy, Gabrielli, Brian, Hill, Michelle M., Sweet, Matthew J., Clouston, Andrew D. and Powell, Elizabeth E. (2014) Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration. World Journal of Gastroenterology, 20 47: 17851-17862. doi:10.3748/wjg.v20.i47.17851
Fagan, K. J., Zhao, Eileen Y., Horsfall, L. U., Ruffin, Brittany J., Kruger, Mark S., McPhail, S. M., O'Rourke, Peter, Ballard, Emma, Irvine, K. M. and Powell, E. E. (2014) Burden of decompensated cirrhosis and ascites on hospital services in a tertiary care facility: time for change?. Internal Medicine Journal, 44 9: 865-872. doi:10.1111/imj.12491
Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers
Fagan K.J., Irvine K.M., McWhinney B.C., Fletcher L.M., Horsfall L.U., Johnson L., O'Rourke P., Martin J., Scott I., Pretorius C.J., Ungerer J.P.J. and Powell E.E. (2014) Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers. BMC Gastroenterology, 14 1: 1-6. doi:10.1186/1471-230X-14-97
The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease
Gadd, Victoria L., Skoien, Richard, Powell, Elizabeth E., Fagan, Kevin J., Winterford, Clay, Horsfall, Leigh, Irvine, Katharine and Clouston, Andrew D. (2014) The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease. Hepatology, 59 4: 1393-1405. doi:10.1002/hep.26937
New paradigms in the histopathology of NAFLD
Clouston, Andrew D., Gadd, Victoria L., Irvine, Katharine M. and Powell, Elizabeth E. (2014) New paradigms in the histopathology of NAFLD. Current Hepatitis Reports, 13 2: 81-87. doi:10.1007/s11901-014-0214-x
Yu, C.-H., Nguyen, T.T.K., Irvine, K.M., Sweet, M.J., Frazer, I.H. and Blumenthal, A. (2014) Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European Journal of Immunology, 44 5: 1480-1490. doi:10.1002/eji.201343959
Fagan, K. J., Irvine, K. M., Kumar, S., Bates, A., Horsfall, L. U., Feeney, G. F. and Powell, E. E. (2013) Assessment of alcohol histories obtained from patients with liver disease: opportunities to improve early intervention. Internal Medicine Journal, 43 10: 1096-1102. doi:10.1111/imj.12229
Fagan, Kevin J., Irvine, Katharine M., McWhinney, Brett C., Fletcher, Linda M., Horsfall, Leigh U., Johnson, Lambro A., Clouston, Andrew D., Jonsson, Julie R., O'Rourke, Peter, Martin, Jennifer, Pretorius, Carel J., Ungerer, Jacobus P. J. and Powell, Elizabeth E. (2013) BMI But Not Stage or Etiology of Nonalcoholic Liver Disease Affects the Diagnostic Utility of Carbohydrate-Deficient Transferrin. Alcoholism Clinical and Experimental Research, 37 10: 1771-1778. doi:10.1111/acer.12143
Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013) Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 35: 25362-25374. doi:10.1074/jbc.M113.496281
Gadd, Victoria L., Melino, Michelle, Roy, Sandrine, Horsfall, Leigh, O'Rourke, Peter, Williams, Millicent R., Irvine, Katharine M., Sweet, Matthew J., Jonsson, Julie R., Clouston, Andrew D. and Powell, Elizabeth E. (2013) Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C. Liver International, 33 4: 569-579. doi:10.1111/liv.12050
Schroder, Kate, Sagulenko, Vitaliya, Zamoshnikova, Alina, Richards, Ayanthi A., Cridland, Jasmyn A., Irvine, Katharine M., Stacey, Katryn J. and Sweet, Matthew J. (2012) Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology, 217 12: 1325-1329. doi:10.1016/j.imbio.2012.07.020
Liver repercussions of defective gut surveillance
Irvine, Katharine M., Schroder, Elizabeth E. and Powell, Elizabeth E. (2012) Liver repercussions of defective gut surveillance. Hepatology, 56 3: 1174-1177. doi:10.1002/hep.25944
Irvine, Katharine M., Gallego, Patricia, An, Xiaoyu, Best, Shannon E., Thomas, Gethin, Wells, Christine, Harris, Mark, Cotterill, Andrew and Thomas, Ranjeny (2012) Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes. Diabetes, 61 5: 1281-1290. doi:10.2337/db11-1549
Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012) Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 16: E944-E953. doi:10.1073/pnas.1110156109
Histone deacetylases as regulators of inflammation and immunity
Shakespear, Melanie R., Halili, Maria A., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2011) Histone deacetylases as regulators of inflammation and immunity. Trends in Immunology, 32 7: 335-343. doi:10.1016/j.it.2011.04.001
Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011) Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 1: e15723-1-e15723-13. doi:10.1371/journal.pone.0015723
Kawaji, H, Severin, J, Lizio, M, Forrest, ARR, van Nimwegen, E, Rehli, M, Schroder, K, Irvine, K, Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, CO (2011) Update of the FANTOM web resource: From mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Research, 39 Supp. 1: D856-D860. doi:10.1093/nar/gkq1112
Kubosaki, A, Lindgren, G, Tagami, M, Simon, C, Tomaru, Y, Miura, H, Suzuki, T, Arner, E, Forrest, ARR, Irvine, KM, Schroder, K, Hasegawa, Y, Kanamori-Katayama, M, Rehli, M, Hume, DA, Kawai, J, Suzuki, M, Suzuki, H and Hayashizaki, Y (2010) The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology, 47 14: 2295-2302. doi:10.1016/j.molimm.2010.05.289
Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010) Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 6: 1103-1114. doi:10.1189/jlb.0509363
Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009)
Taft, Ryan J., Glazov, Evgeny A., Cloonan, Nicole, Simons, Cas, Stephen, Stuart, Faulkner, Geoffrey J., Lassmann, Timo, Forrest, Alistair R. R., Grimmond, Sean M., Schroder, Kate, Irvine, Katharine, Arakawa, Takahiro, Nakamura, Mari, Kubosaki, Atsutaka, Hayashida, Kengo, Kawazu, Chika, Murata, Mitsuyoshi, Nishiyori, Hiromi, Fukuda, Shiro, Kawai, Jun, Daub, Carsten O., Hume, David A., Suzuki, Harukazu, Orlando, Valerio, Carninci, Piero, Hayashizaki, Yoshihide and Mattick, John S. (2009) Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009). Nature Genetics, 41 7: 859-859. doi:10.1038/ng0709-859a
Goh, Felicia, Irvine, Katharine M., Lovelace, Erica, Donnelly, Sheila, Jones, Malcolm K ., Brion, Kristian, Hume, David A., Kotze, Andrew C., Dalton John P., Ingham, Aaron and Sweet, Matthew J. (2009) Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immunology, 127 3: 326-337. doi:10.1111/j.1365-2567.2008.02979.x
The regulated retrotransposon transcriptome of mammalian cells
Faulkner, Geoffrey J., Kimura, Yasumasa, Daub, Carsten O., Wani, Shivangi, Plessy, Charles, Irvine, Katharine M., Schroder, Kate, Cloonan, Nicole, Steptoe, Anita L., Lassmann, Timo, Waki, Kazunori, Hornig, Nadine, Arakawa, Takahiro, Takahashi, Hazuki, Kawai, Jun, Forrest, Alistair R. R., Suzuki, Harukazu, Hayashizaki, Yoshihide, Hume, David A., Orlando, Valerio, Grimmond, Sean M. and Carninci, Piero (2009) The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics, 41 5: 563-571. doi:10.1038/ng.368
Suzuki, H, Forrest, ARR, van Nimwegen, E, Daub, CO, Balwierz, PJ, Irvine, KM, Lassmann, T, Ravasi, T, Hasegawa, Y, de Hoon, MJL, Katayama, S, Schroder, K, Carninci, P, Tomaru, Y, Kanamori-Katayama, M, Kubosaki, A, Akalin, A, Ando, Y, Arner, E, Asada, M, Asahara, H, Bailey, T, Bajic, VB, Bauer, D, Beckhouse, AG, Bertin, N, Bjorkegren, J, Brombacher, F, Bulger, E, Chalk, AM, Chiba, J, Cloonan, N, Dawe, A, Dostie, J, Engstrom, PG, Essack, M, Faulkner, GJ, Fink, JL, Fredman, D, Fujimori, K, Furuno, M, Gojobori, T, Gough, J, Grimmond, SM, Gustafsson, M, Hashimoto, M, Hashimoto, T, Hatakeyama, M, Heinzel, S, Hide, W, Hofmann, O, Hornquist, M, Huminiecki, L, Ikeo, K, Imamoto, N, Inoue, S, Inoue, Y, Ishihara, R, Iwayanagi, T, Jacobsen, A, Kaur, M, Kawaji, H, Kerr, MC, Kimura, R, Kimura, S, Kimura, Y, Kitano, H, Koga, H, Kojima, T, Kondo, S, Konno, T, Krogh, A, Kruger, A, Kumar, A, Lenhard, B, Lennartsson, A, Lindow, M, Lizio, M, MacPherson, C, Maeda, N, Maher, CA, Maqungo, M, Mar, J, Matigian, NA, Matsuda, H, Mattick, JS, Meier, S, Miyamoto, S, Miyamoto-Sato, E, Nakabayashi, K, Nakachi, Y, Nakano, M, Nygaard, S, Okayama, T, Okazaki, Y, Okuda-Yabukami, H, Orlando, V, Otomo, J, Pachkov, M, Petrovsky, N, Plessy, C, Quackenbush, J, Radovanovic, A, Rehli, M, Saito, R, Sandelin, A, Schmeier, S, Schonbach, C, Schwartz, AS, Semple, CA, Sera, M, Severin, J, Shirahige, K, Simons, C, Laurent, GS, Suzuki, M, Suzuki, T, Sweet, MJ, Taft, RJ, Takeda, S, Takenaka, Y, Tan, K, Taylor, MS, Teasdale, RD, Tegner, J, Teichmann, S, Valen, E, Wahlestedt, C, Waki, K, Waterhouse, A, Wells, Christine A., Winther, O, Wu, L, Yamaguchi, K, Yanagawa, H, Yasuda, J, Zavolan, M, Hume, DA, Arakawa, T, Fukuda, S, Imamura, K, Kai, C, Kaiho, A, Kawashima, T, Kawazu, C, Kitazume, Y, Kojima, M, Miura, H, Murakami, K, Murata, M, Ninomiya, N, Nishiyori, H, Noma, S, Ogawa, C, Sano, T, Simon, C, Tagami, M, Takahashi, Y, Kawai, J, Hayashizaki, Y, FANTOM Consortium and Riken Omics Science Center (2009) The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics, 41 5: 553-562. doi:10.1038/ng.375
Tiny RNAs associated with transcription start sites in animals
Taft, RJ, Glazov, EA, Cloonan, N, Simons, C, Stephen, S, Faulkner, GJ, Lassmann, T, Forrest, ARR, Grimmond, SM, Schroder, K, Irvine, K, Arakawa, T, Nakamura, M, Kubosaki, A, Hayashida, K, Kawazu, C, Murata, M, Nishiyori, H, Fukuda, S, Kawai, J, Daub, CO, Hume, DA, Suzuki, H, Orlando, V, Carninci, P, Hayashizaki, Y and Mattick, JS (2009) Tiny RNAs associated with transcription start sites in animals. Nature Genetics, 41 5: 572-578. doi:10.1038/ng.312
Data-driven normalization strategies for high-throughput quantitative RT-PCR
Mar, Jessica C., Kimura, Yasumasa, Schroder, Kate, Irvine, Katherine M., Hayashizaki, Yoshihide, Suzuki, Harukazu, Hume, David and Quackenbush, John (2009) Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics, 10 110.1-110.10. doi:10.1186/1471-2105-10-110
The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation
Kawaji, H, Severin, J, Lizio, M, Waterhouse, A, Katayama, S, Irvine, K. M., Hume, D. A., Forrest, A. R. R., Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, C. O. (2009) The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Genome Biology, 10 4: . doi:10.1186/gb-2009-10-4-r40
Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages
Irvine, Katharine M., Andrews, Melanie R., Fernandez-Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A. and Sweet, Matthew J. (2009) Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology, 85 2: 278-288. doi:10.1189/jlb.0808497
Maeda, Norihiro, Nishiyori, Hiromi , Nakamura, Mari , Kawazu, Chika, Murata, Mitsuyoshi , Sano, Hiromi, Hayashida, Kengo, Fukuda, Shiro, Tagami, Michihira, Hasegawa, Akira, Murakami, Kayoko, Schroder, Kate, Irvine, Katharine, Hume, David A., Hayashizaki, Yoshihide, Carninci, Piero and Suzuki, Harukazu (2008) Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer. BioTechniques, 45 1: 95-97. doi:10.2144/000112814
Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K. A., Irvine, K. M., Burrows, A. D., Ravasi, T., Weighardt, H., Stacey, K. J., Decker, T., Hume, D. A., Dalpke, A. H. and Sweet, M. J. (2007) Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology, 179 6: 3495-3503. doi:10.4049/jimmunol.179.6.3495
Schroder, Kate, Lichtinger, Monika, Irvine, Katharine M., Brion, Kristian, Trieu, Angela, Ross, Ian L., Ravasi, Timothy, Stacey, Katryn J., Rehli, Michael, Hume, David A. and Sweet, Matthew J. (2007) PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology, 81 6: 1577-1590. doi:10.1189/jlb.0107036
Ripoll, Vera M., Irvine, Katharine M., Ravasi, Timothy, Sweet, Matthew J. and Hume, David A. (2007) Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. Journal of Immunology, 178 10: 6557-6566. doi:10.4049/jimmunol.178.10.6557
Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2006) A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. The FASEB Journal, 20 11: 1921-1923. doi:10.1096/fj.06-5848fje
Rasputin, more promiscuous than ever: a review of G3BP
Irvine, K., Stirling, R., Hume, D. and Kennedy, D. (2004) Rasputin, more promiscuous than ever: a review of G3BP. International Journal of Developmental Biology, 48 10: 1065-1077. doi:10.1387/ijdb.041893ki
Irvine, Katharine, Genz, Berit, Clouston, Andrew D. and Hume, David (2018). Macrophage Colony Stimulating Factor (CSF1) Promotes Regression of Advanced Fibrosis and Liver Regeneration in Mice. In: Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, San Francisco Ca, (635A-635A). Nov 09-13, 2018.
Advanced fibrosis is associated with longitudinal increases in Fibrosis-4 and NAFLD fibrosis scores
Patel, Preya, Cheng, Johnson Chieh-Yu, Banh, Xuan, Hossain, Fabrina, Horsfall, Leigh Ula, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Stuart, Katherine A., Russell, Anthony William, Valery, Patricia Casarolli, Irvine, Katharine, Clouston, Andrew D., Bernard, Anne and Powell, Elizabeth E. (2018). Advanced fibrosis is associated with longitudinal increases in Fibrosis-4 and NAFLD fibrosis scores. In: Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) / Liver Meeting, San Francisco, CA, United States, (1291A-1291A). Nov 09-13, 2018. doi:10.1002/hep.30257
Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E. and Sweet, M. (2018). RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease. In: International Liver Congress (ILC), Paris, France, (S401-S402). 11-15 April, 2018. doi:10.1016/S0168-8278(18)31040-7
Patel, P. J., Smith, D. D., Stuart, K. A., Horsfall, L. U., Hayward, K. L., Hossain, F., Williams, S., Johnson, T., Brown, N. N., Saad, N., Clouston, A. D., Irvine, K. M., Russell, A. W., Valery, P. C. and Powell, E. E. (2017). Can modest alcohol intake be dismissed as a co-factor in diabetic patients with non-alcoholic fatty liver disease?. In: Journal of Hepatology. International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Amsterdam Netherlands, (S588-S588). Apr 19-23, 2017. doi:10.1016/S0168-8278(17)31602-1
Patel, P. J., Stuart, K. A., Horsfall, L. U., Hayward, K. L., Hossain, F., Williams, S., Johnson, T., Brown, N., Lampe, G., Buck, L., Saad, N., Clouston, A., Irvine, K. M., Russell, A., Valery, P. C. and Powell, E. E. (2017). Enhanced Liver Fibrosis test and liver stiffness measurements identify high prevalence of advanced fibrosis in people with type 2 diabetes. In: , , (103-103). .
High-risk medication-related problems are prevalent in people with decompensated cirrhosis
Hayward, K. L., Patel, P. J., Valery, P. C., Horsfall, L. U., Li, C. Y., Wright, P. L., Tallis, C. J., Stuart, K. A., Irvine, K. M., Cottrell, W. N., Powell, E. E. and Martin, J. H. (2017). High-risk medication-related problems are prevalent in people with decompensated cirrhosis. In: Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD, Australia, (95-95). 20 - 22 August 2017.
Medication beliefs predict low medication adherence in people with decompensated cirrhosis
Hayward, K. L., Valery, P. C., Martin, J. H., Karmakar, A., Patel, P. J., Horsfall, L. U., Irvine, K. M., Stuart, K. A., Tallis, C. J., Wright, P. L., Smith, D. D., Powell, E. E. and Cottrell, W. N. (2017). Medication beliefs predict low medication adherence in people with decompensated cirrhosis. In: International Liver Congress / 52nd Annual Meeting of the European Association for the Study of the Liver. International Liver Congress / 52nd Annual Meeting of the European Association for the Study of the Liver, Amsterdam, The Netherlands, (S382-S383). 19 - 23 April 2017. doi:10.1016/S0168-8278(17)31113-3
Medication adherence in outpatients with decompensated cirrhosis
Hayward, K. L., Cottrell, W. N., Karmakar, A., Patel, P. J., Horsfall, L. U., Martin, J. H., Irvine, K. M., Tallis, C. J., Wright, P. L., Stuart, K. A., Valery, P. C. and Powell, E. E. (2016). Medication adherence in outpatients with decompensated cirrhosis. In: Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, (103-103). 10–12 October, 2016. doi:10.1111/jgh.13520
Non-invasive markers indicate a high prevalence of advanced fibrosis in adults with type 2 diabetes
Patel, P. J., Stuart, K. A., Horsfall, L. U., Hossain, F., Williams, S., Johnson, T., Brown, N., Lampe, G., Buck, L., Clouston, A., Irvine, K. M., Russell, A. and Powell, E. E. (2016). Non-invasive markers indicate a high prevalence of advanced fibrosis in adults with type 2 diabetes. In: Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, (114-115). 10–12 October, 2016. doi:10.1111/jgh.13520
Irvine, K. M., Clouston, A. D., Blumenthal, A. and Powell, E. E. (2015). Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation. In: Abstracts of Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD, Australia, (7-7). 28 September - 2 October 2015. doi:10.1111/jgh.13087
Irvine, Katharine, Clouston, Andrew D., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury. In: 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, United States, (878A-878A). Nov 13-17, 2015.
Discrepancies in the use of medications in patients with cirrhosis
Hayward, K., Valery, P. C., Cottrell, N., Irvine, K., Horsfall, L., Ruffin, B., Tallis, C., Chachay, V., Martin, J. and Powell, E. (2015). Discrepancies in the use of medications in patients with cirrhosis. In: Abstracts of Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD, Australi, (101-102). 28 September - 2 October 2015. doi:10.1111/jgh.13093
Mcphail, S. M., Horsfall, L., Irvine, K., Fagan, K. J. and Powell, E. E. (2015). Economic consideration for reducing hospital presentations among patients with decompensated cirrhosis: not all presentations avoided can be considered equal. In: Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 World Congress of Gastroenterology, Brisbane, Queensland, Australia, (108-109). 28 September-2 October 2015. doi:10.1111/jgh.13093
Patterns of service utilisation within hepatology clinics: high prevalence of advanced liver disease
El-Atem, N., Wojcik, K., Horsfall, L., Irvine, K., Johnson, T., Mcphail, S. M. and Powell, E. E. (2015). Patterns of service utilisation within hepatology clinics: high prevalence of advanced liver disease. In: Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, (100-101). 28 September-2 October 2015. doi:10.1111/jgh.13093
Irvine, K. M., Wockner, L. F., Shanker, M., Fagan, K. J., Horsfall, L. U., Fletcher, L. M., Ungerer, J., Pretorius, C. J., Miller, G. C., Clouston, A. D., Lampe, G. and Powell, E. E. (2015). Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores. In: Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, (104-105). 28 September-2 October 2015. doi:10.1111/jgh.13093
Irvine, Katharine, Wockner, Leesa F., Shanker, Mihir, Fagan, Kevin, Horsfall, Leigh, Fletcher, Linda, Ungerer, Jacobus, Pretorius, Carel J., Miller, Gregory, Clouston, Andrew D., Lampe, Guy and Powell, Elizabeth E. (2015). Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores. In: 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, CA, United States, (600A-600A). 13-17 November 2015. doi:10.1002/hep.28218
Fagan, K., Horsfall, L., Irvine, K., Fletcher, L., Tate, J., Choi, K., Nusrat, S., Melino, M., Clouston, A., Ballard, E., O'Rourke, P., Lampe, G., Ungerer, J. and Powell, E. (2014). An ELF score of >= 9.8 can identify advanced fibrosis in Australian patients with chronic liver disease. In: Journal of Gastroenterology and Hepatology. , , (77-78). .
Fagan, K. J., Melino, M., Powell, E. E. and Irvine, K. M. (2014). Microbial burden is associated with clinical outcomes and reduced ascites innate immune cells in non-infected ascites. In: Special Issue: Australian Gastroenterology Week 2014. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, (81-81). 22-24 October 2014. doi:10.1111/jgh.12736_5
Melino, M., Gadd, V., Martinez, M., Lineburg, K., Irvine, K., Clouston, A. D., Powell, E. E. and Macdonald, K. P. (2014). Spaciotemporal characterization of the cellular and molecular contributors to chronic hepatic fibrosis in a hepatotoxin-induced mouse model. In: Special Issue: Australian Gastroenterology Week 2014. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, (8-9). 22-24 October 2014. doi:10.1111/jgh.12736
The Portal Inflammatory Infiltrate and Ductular Niche in Non-Alcoholic Fatty Liver Disease
Gadd, Victoria L., Skoien, Richard, Fagan, Kevin, Irvine, Katharine, Powell, Elizabeth E. and Clouston, Andrew D. (2013). The Portal Inflammatory Infiltrate and Ductular Niche in Non-Alcoholic Fatty Liver Disease. In: 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases, Washington Dc, (458A-458A). Nov 01-05, 2013.
Fagan, K., Irvine, K., Kumar, S., Bates, A., Horsfall, L., Feeney, G. and Powell, E. (2013). Assessment of alcohol histories obtained from patients with liver disease: Opportunities to improve early intervention. In: Australian Gastroenterology Week 2013, Melbourne, Australia, (61-61). 7-9 October 2013. doi:10.1111/jgh.12365_5
Fagan, K., Irvine, K., McWhinney, B., Fletcher, L., Horsfall, L., Johnson, L., Clouston, A., Jonsson, J., O'Rourke, P., Martin, J., Pretorius, C., Ungerer, J. and Powell, E. (2013). BMI but not aetiology or stage of liver disease affects the diagnostic sensitivity of carbohydrate deficient transferrin. In: International Liver Congress / 48th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Amsterdam Netherlands, (S215-S215). 24-28 April 2013. doi:10.1016/S0168-8278(13)60527-9
Factors associated with mortality and unplanned hospital readmissions in patients with ascites
Zhao, E., Horsfall, L., Ruffin, B. J., Fagan, K. J., Irvine, K. M. and Powell, E. E. (2013). Factors associated with mortality and unplanned hospital readmissions in patients with ascites. In: Australian Gastroenterology Week 2013, Melbourne, Australia, (79-80). 7-9 October 2013. doi:10.1111/jgh.12365_5
The portal inflammatory infiltrate and ductular niche in non-alcoholic fatty liver disease
Gadd, V., Skoien, R., Fagan, K., Irvine, K., Powell, E. and Clouston, A. (2013). The portal inflammatory infiltrate and ductular niche in non-alcoholic fatty liver disease. In: Australian Gastroenterology Week 2013, Melbourne Australia, (9-10). 7-9 October 2013. doi:10.1111/jgh.12365
Sweet, M. J., Schroder, K., Irvine, K. M., Taylor, M., Bokil, N. J., Broomfield, S., Schembri, M. A., Stacey, K. J. and Hume, D. A. (2012). Functional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouse. In: Abstracts of the European Congress of Immunology. European Congress of Immunology, Glasgow, Scotland, (297-297). 5-8 September 2012. doi:10.1111/imm.12002
The identification of novel CSF-1 target genes in human macrophages
Irvine, Katharine M., Andrews, Melanie R., Fernandez, Manuel A., Parton, Robert G., Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Hume, David A. and Sweet, M. J. (2008). The identification of novel CSF-1 target genes in human macrophages. In: Cytokine. 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal Canada, (245-245). Oct 12-16, 2008. doi:10.1016/j.cyto.2008.07.078
Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Bu, Xiangyong, Harte, Michael F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2005). A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations. In: Inflammation Research. , , (S148-S148). .
PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages
Schroder, Kate, Irvine, Katharine M., Biron, Kristian, Lichtinger, Monika, Ravasi, Timothy, Rehli, Michael, Sweet, Matthen J. and Hume, David A. (2005). PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages. In: Inflammation Research. , , (S186-S187). .
The expression and function of G3BPs in macrophages
Irvine, Katharine Margaret. (2004). The expression and function of G3BPs in macrophages PhD Thesis, Institute for Molecular Bioscience, The University of Queensland.
CSF1 Therapy for Chronic Liver Disease
(2019–2021) NHMRC Project Grant
(2019–2020) Mater Foundation
Serum biomarkers for risk stratification in nonalcoholic fatty liver disease
(2015–2017) Siemens Ltd
(2015–2016) PA Research Foundation
Human liver progenitor cell characterisation, isolation and manipulation
(2014) UWA-UQ Bilateral Research Collaboration Award
Defining the role of MMP-9-expressing macrophages in liver injury in chronic liver disease
(2013–2015) NHMRC Project Grant
ALF Pauline Hall Research Fellowship: The role of macrophage in chronic liver disease progression
(2012–2015) Australian Liver Foundation
Pathological changes associated with chronic RelB activiation in T1D
(2010–2012) Juvenile Diabetes Research Foundation
Human macrophage transcriptional network
(2005–2008) Riken Genomic Sciences Center
Targeting Peritoneal immunity to improve outcomes in patients with cirrhosis and ascites
Master Philosophy — Principal Advisor
Other advisors:
The impacts of Csf1r insufficiency on microglia and brain development
Doctor Philosophy — Associate Advisor
Other advisors:
The function of macrophages in development and physiology
Doctor Philosophy — Associate Advisor
Other advisors:
Macrophage colony stimulating factor as a treatment for chronic liver disease
Doctor Philosophy — Associate Advisor
Other advisors:
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
(2015) Doctor Philosophy — Associate Advisor
Other advisors:
Cytokines and STAT3 signalling in autoimmune diseases
(2015) Doctor Philosophy — Associate Advisor
Other advisors:
Regulation of TLR4 signalling in macrophages by histone deacetylases
(2013) Doctor Philosophy — Associate Advisor
Other advisors: