The University of Queensland

Stathmin and cancer

Ng, Dominic Chi Hiung and Byrne, Frances (2012). Stathmin and cancer. Cytoskeleton and Human Disease. (pp. 259-284) edited by Maria Kavallaris. New York, NY USA: Humana Press. doi: 10.1007/978-1-61779-788-0_14

Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

Ding, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

Rashidieh, Behnam, Shohayeb, Belal, Bain, Amanda Louise, Fortuna, Patrick R. J., Sinha, Debottam, Burgess, Andrew, Mills, Richard, Adams, Rachael C., Lopez, J. Alejandro, Blumbergs, Peter, Finnie, John, Kalimutho, Murugan, Piper, Michael, Hudson, James Edward, Ng, Dominic C. H. and Khanna, Kum Kum (2021). Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis. PLoS Genetics, 17 (10) e1009334, e1009334. doi: 10.1371/journal.pgen.1009334

Cilia, centrosomes and skeletal muscle

Ng, Dominic C. H., Ho, Uda Y. and Grounds, Miranda D. (2021). Cilia, centrosomes and skeletal muscle. International Journal of Molecular Sciences, 22 (17) 9605, 9605. doi: 10.3390/ijms22179605

TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells

Ding, Qiao, Chaplin, Justin, Morris, Matthew J., Hilliard, Massimo A., Wolvetang, Ernst, Ng, Dominic C. H. and Noakes, Peter G. (2021). TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells. Frontiers in Cell and Developmental Biology, 9 611601, 611601. doi: 10.3389/fcell.2021.611601

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis

Ho, Uda Y., Feng, Chun-Wei Allen, Yeap, Yvonne Y., Bain, Amanda L., Wei, Zhe, Shohayeb, Belal, Reichelt, Melissa E., Homer, Hayden, Khanna, Kum Kum, Bowles, Josephine and Ng, Dominic C. H. (2021). WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Communications Biology, 4 (1) 645, 1-14. doi: 10.1038/s42003-021-02171-5

Pathophysiological significance of WDR62 and JNK signaling in human diseases

Zhi, Yiqiang, Zhou, Xiaokun, Yu, Jurui, Yuan, Ling, Zhang, Hongsheng, Ng, Dominic C. H., Xu, Zhiheng and Xu, Dan (2021). Pathophysiological significance of WDR62 and JNK signaling in human diseases. Frontiers in Cell and Developmental Biology, 9 640753, 640753. doi: 10.3389/fcell.2021.640753

Centrosome reduction promotes terminal differentiation of human cardiomyocytes

Ng, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K. and Hudson, James E. (2020). Centrosome reduction promotes terminal differentiation of human cardiomyocytes. Stem Cell Reports, 15 (4), 817-826. doi: 10.1016/j.stemcr.2020.08.007

The spindle-associated microcephaly protein, WDR62, is required for neurogenesis and development of the hippocampus

Shohayeb, Belal, Ho, Uda Y., Hassan, Halah, Piper, Michael and Ng, Dominic C. H. (2020). The spindle-associated microcephaly protein, WDR62, is required for neurogenesis and development of the hippocampus. Frontiers in Cell and Developmental Biology, 8 549353, 549353. doi: 10.3389/fcell.2020.549353

Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC

Shohayeb, Belal, Mitchell, Naomi, Millard, S. Sean, Quinn, Leonie M. and Ng, Dominic C.H. (2020). Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC. Biochimica et Biophysica Acta - Molecular Cell Research, 1867 (7) 118713, 118713. doi: 10.1016/j.bbamcr.2020.118713

The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development

Shohayeb, Belal, Ho, Uda, Yeap, Yvonne Y., Parton, Robert G., Millard, Sean S., Xu, Zhiheng, Piper, Michael and Ng, Dominic C. H. (2020). The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. Human Molecular Genetics, 29 (2), 248-263. doi: 10.1093/hmg/ddz281

Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association

Moslehi, Maryam, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2019). Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association. Biochemical and Biophysical Research Communications, 513 (3), 540-545. doi: 10.1016/j.bbrc.2019.04.005

Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments

Moslehi, Maryam, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2019). Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments. Biochimica et Biophysica Acta - Molecular Cell Research, 1866 (4), 638-649. doi: 10.1016/j.bbamcr.2019.01.003

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Hoque, Ashfaqul, Williamson, Nicholas A., Ameen, S. Sadia, Ciccotosto, Giuseppe D., Hossain, M. Iqbal, Oakhill, Jonathan S., Ng, Dominic C. H., Ang, Ching-Seng and Cheng, Heung-Chin (2019). Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death. Cell Death and Disease, 10 (3) 213, 213. doi: 10.1038/s41419-019-1445-0

MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis

Xu, Dan, Yao, Minghui, Wang, Yaqing, Yuan, Ling, Hoeck, Joerg D., Yu, Jingwen, Liu, Liang, Yeap, Yvonne Y. C., Zhang, Weiya, Zhang, Feng, Feng, Yinghang, Ma, Tiantian, Wang, Yujie, Ng, Dominic C. H., Niu, Xiaoyin, Su, Bing, Behrens, Axel and Xu, Zhiheng (2018). MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. Plos Biology, 16 (12) e2006613, e2006613. doi: 10.1371/journal.pbio.2006613

Flavonols and flavones - protecting against myocardial ischemia/reperfusion injury by targeting protein kinases

Woodman, Owen L., Chin, Kai Yee, Thomas, Colleen J., Ng, Dominic C. H. and May, Clive N. (2018). Flavonols and flavones - protecting against myocardial ischemia/reperfusion injury by targeting protein kinases. Current Medicinal Chemistry, 25 (34), 4402-4415. doi: 10.2174/0929867325666180326161730

Factors that influence adult neurogenesis as potential therapy

Shohayeb, Belal, Diab, Mohamed, Ahmed, Mazen and Ng, Dominic Chi Hiung (2018). Factors that influence adult neurogenesis as potential therapy. Translational Neurodegeneration, 7 (1) 4, 1-19. doi: 10.1186/s40035-018-0109-9

Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2

Chin, Kai Yee, Silva, Lokugan S., Darby, Ian A., Ng, Dominic C. H. and Woodman, Owen L. (2018). Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2. International Journal of Cardiology, 254, 265-271. doi: 10.1016/j.ijcard.2017.11.101

The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development

Shohayeb, Belal, Lim, Nicholas Rui, Ho, Uda, Xu, Zhiheng, Dottori, Mirella, Quinn, Leonie and Ng, Dominic Chi Hiung (2017). The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development. Molecular Neurobiology, 55 (7), 5409-5424. doi: 10.1007/s12035-017-0778-x

Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus

Moslehi, Maryam, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2017). Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus. Scientific Reports, 7 (1) 5245, 5245. doi: 10.1038/s41598-017-05340-x

Glial-specific functions of microcephaly protein WDR62 and interaction with the mitotic kinase AURKA are essential for Drosophila brain growth

Lim, Nicholas R., Shohayeb, Belal, Zaytseva, Olga, Mitchell, Naomi, Millard, S. Sean, Ng, Dominic C. H. and Quinn, Leonie M. (2017). Glial-specific functions of microcephaly protein WDR62 and interaction with the mitotic kinase AURKA are essential for Drosophila brain growth. Stem Cell Reports, 9 (1), 32-41. doi: 10.1016/j.stemcr.2017.05.015

Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration

Fife, C. M., Sagnella, S. M., Teo, W. S., Po'Uha, S. T., Byrne, F. L., Yeap, Y. Y. C., Ng, D. C. H., Davis, T. P., McCarroll, J. A. and Kavallaris, M. (2017). Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration. Intensive Care Medicine, 36 (4), 501-511. doi: 10.1038/onc.2016.220

WDR62 regulates early neural and glial progenitor specification of human pluripotent stem cells

Alshawaf, Abdulah J., Antonic, Ana, Skafidas, Efstratios, Ng, Dominic Chi-Hung and Dottori, Mirella (2017). WDR62 regulates early neural and glial progenitor specification of human pluripotent stem cells. Stem Cells International, 2017 7848932, 7848932-9. doi: 10.1155/2017/7848932

A beacon of hope in stroke therapy - blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

Hoque, Ashfaqul, Hossain, M. Iqbal, Ameen, S. Sadia, Ang, Ching-Seng, Williamson, Nicholas, Ng, Dominic C. H., Chueh, Anderly C., Roulston, Carli and Cheng, Heung-Chin (2016). A beacon of hope in stroke therapy - blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies. Pharmacology and Therapeutics, 160, 159-179. doi: 10.1016/j.pharmthera.2016.02.009

Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation

Lim, Nicholas R., Yeap, Yvonne Y. C., Ang, Ching-Seng, Williamson, Nicholas A., Bogoyevitch, Marie A., Quinn, Leonie M. and Ng, Dominic C. H. (2016). Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation. Cell Cycle, 15 (3), 413-424. doi: 10.1080/15384101.2015.1127472

Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3′,4′-dihydroxyflavonol

Thomas, Colleen J., Lim, Nicholas R., Kedikaetswe, Alphious, Yeap, Yvonne Y., Woodman, Owen L., Ng, Dominic C. H. and May, Clive N. (2015). Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3′,4′-dihydroxyflavonol. European Journal of Pharmacology, 758, 53-59. doi: 10.1016/j.ejphar.2015.03.054

Loss of miR-223 and JNK signaling contribute to elevated Stathmin in malignant pleural mesothelioma

Birnie, Kimberly A., Yip, Yan Y., Ng, Dominic C. H., Kirschner, Michaela B., Reid, Glen, Prele, Cecilia M., Musk, Arthur W. (Bill), Lee, Y. C. Gary, Thompson, Philip J., Mutsaers, Steven E. and Badrian, Bahareh (2015). Loss of miR-223 and JNK signaling contribute to elevated Stathmin in malignant pleural mesothelioma. Molecular Cancer Research, 13 (7), 1106-1118. doi: 10.1158/1541-7786.MCR-14-0442

Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart

Bell, James R., Raaijmakers, Antonia J. A., Curl, Claire L., Reichelt, Melissa E., Harding, TristanW., Bei, Aier, Ng, Dominic C. H., Erickson, Jeffrey R., Petroff, Martin Vila, Harrap, Stephen B. and Delbridge, Lea M. D. (2015). Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart. International Journal of Cardiology, 181, 288-296. doi: 10.1016/j.ijcard.2014.11.159

Dual role of Src kinase in governing neuronal survival

Hossaina, M. Iqbal, Hoquel, Ashfaqul, Lessene, Guillaume, Kamaruddin, M. Aizuddin, Chu, Percy W. Y., Ng, Ivan H. W., Irtegun, Sevgi, Ng, Dominic C. H., Bogoyevitch, Marie A., Burgess, Antony W., Hill, Andrew F. and Cheng, Heung-Chin (2015). Dual role of Src kinase in governing neuronal survival. Brain Research, 1594, 1-14. doi: 10.1016/j.brainres.2014.10.040

Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules

Lim, Nicholas R., Yeap, Yvonne Y. C., Zhao, Teresa T., Yip, Yan Y., Wong, Shu C., Xu, Dan, Ang, Ching-Seng, Williamson, Nicholas A., Xu, Zhiheng, Bogoyevitch, Marie A. and Ng, Dominic C. H. (2015). Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules. Journal of Cell Science, 128 (3), 527-540. doi: 10.1242/jcs.157537

Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members

Yip, Yan Y., Yeap, Yvonne Y. C., Bogoyevitch, Marie A. and Ng, Dominic C. H. (2014). Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members. Biochemical and Biophysical Research Communications, 446 (1), 248-254. doi: 10.1016/j.bbrc.2014.02.101

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

Misheva, Mariya, Kaur, Gurpreet, Ngoei, Kevin R. W., Yeap, Yvonne Y., Ng, Ivan H. W., Wagstaff, Kylie M., Ng, Dominic C. H., Jans, David A. and Bogoyevitch, Marie A. (2014). Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. BBA- Molecular Cell Research, 1843 (2), 253-264. doi: 10.1016/j.bbamcr.2013.10.017

CAMP-dependent protein kinase and c-jun n-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress

Yip, Yan Y., Yeap, Yvonne Y. C., Bogoyevitch, Marie A. and Ng, Dominic C. H. (2014). CAMP-dependent protein kinase and c-jun n-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress. Journal of Biological Chemistry, 289 (4), 2157-2169. doi: 10.1074/jbc.M113.470682

Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition

Lim, Nicholas R., Thomas, Colleen J., Silva, Lokugan S., Yeap, Yvonne Y., Yap, Suwan, Bell, James R., Delbridge, Lea M. D., Bogoyevitch, Marie A., Woodman, Owen L., Williams, Spencer J., May, Clive N. and Ng, Dominic C. H. (2013). Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition. Biochemical Journal, 456 (2), 149-161. doi: 10.1042/BJ20121538

Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds

Ngoei, Kevin R. W., Ng, Dominic C. H., Gooley, Paul R., Fairlie, David P., Stoermer, Martin J. and Bogoyevitch, Marie A. (2013). Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1834 (6), 1077-1088. doi: 10.1016/j.bbapap.2013.02.001

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity

Hossain, M. Iqbal, Roulston, Carli L., Kamaruddin, M. Aizuddin, Chu, Percy W. Y., Ng, Dominic C. H., Dusting, Gregory J., Bjorge, Jeffrey D., Williamson, Nicholas A., Fujita, Donald J., Cheung, Steve N., Chan, Tung O., Hill, Andrew F. and Cheng, Heung-Chin (2013). A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity. Journal of Biological Chemistry, 288 (14), 9696-9709. doi: 10.1074/jbc.M112.419713

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

Bogoyevitch, Marie A., Yeap, Yvonne Y. C., Qu, Zhengdong, Ngoei, Kevin R., Yip, Yan Y., Zhao, Teresa T., Heng, Julian I. and Ng, Dominic C. H. (2012). WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression. Journal of Cell Science, 125 (21), 5096-5109. doi: 10.1242/jcs.107326

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

Ng, Ivan H. W., Ng, Dominic C. H., Jans, David A. and Bogoyevitch, Marie A. (2012). Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes. Biochemical Journal, 447 (1), 125-136. doi: 10.1042/BJ20120941

Tracking protein aggregation and mislocalization in cells with flow cytometry

Ramdzan, Yasmin M., Polling, Saskia, Chia, Cheryl P. Z., Ng, Ivan H. W., Ormsby, Angelique R., Croft, Nathan P., Purcell, Anthony W., Bogoyevitch, Marie A., Ng, Dominic C. H., Gleeson, Paul A. and Hatters, Danny M. (2012). Tracking protein aggregation and mislocalization in cells with flow cytometry. Nature Methods, 9 (5), 467-470. doi: 10.1038/nmeth.1930

Phosphoinositide 3-Kinase (PI3K(p110 alpha))directly regulates key components of the Z-disc and cardiac structure

Waardenberg, Ashley J., Bernardo, Bianca C., Ng, Dominic C. H., Shepherd, Peter R., Cemerlang, Nelly, Sbroggio, Mauro, Wells, Christine A., Dalrymple, Brian P., Brancaccio, Mara, Lin, Ruby C. Y. and McMullen, Julie R. (2011). Phosphoinositide 3-Kinase (PI3K(p110 alpha))directly regulates key components of the Z-disc and cardiac structure. Journal of Biological Chemistry, 286 (35), 30837-30846. doi: 10.1074/jbc.M111.271684

Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK

Thomas, Colleen J., Ng, Dominic C. H., Patsikatheodorou, Nikolas, Limengka, Yuliardy, Lee, Matthew W. K., Darby, Ian A., Woodman, Owen L. and May, Clive N. (2011). Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK. European Journal of Pharmacology, 658 (2-3), 160-167. doi: 10.1016/j.ejphar.2011.02.041

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

Ngoei, Kevin R. W., Catimel, Bruno, Church, Nicole, Lio, Daisy S., Dogovski, Con, Perugini, Matthew A., Watt, Paul M., Cheng, Heung-Chin, Ng, Dominic C. H. and Bogoyevitch, Marie A. (2011). Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide. Biochemical Journal, 434 (3), 399-413. doi: 10.1042/BJ20101244

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Meyerowitz, Jodi, Parker, Sarah J., Vella, Laura J., Ng, Dominic C. H., Price, Katherine A., Liddell, Jeffrey R., Caragounis, Aphrodite, Li, Qiao-Xin, Masters, Colin L., Nonaka, Takashi, Hasegawa, Masato, Bogoyevitch, Marie A., Kanninen, Katja M., Crouch, Peter J. and White, Anthony R. (2011). C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress. Molecular Neurodegeneration, 6 (57) 57. doi: 10.1186/1750-1326-6-57

Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy

Ng, Dominic C. H., Ng, Ivan H. W., Yeap, Yvonne Y. C., Badrian, Bahareh, Tsoutsman, Tatiana, McMullen, Julie R., Semsarian, Christopher and Bogoyevitch, Marie A. (2011). Opposing actions of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) in regulating microtubule stabilization during cardiac hypertrophy. Journal of Biological Chemistry, 286 (2), 1576-1587. doi: 10.1074/jbc.M110.128157

c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress

Ng, Dominic C. H., Zhao, Teresa T., Yeap, Yvonne Y. C., Ngoei, Kevin R. and Bogoyevitch, Marie A. (2010). c-Jun N-terminal kinase phosphorylation of stathmin confers protection against cellular stress. Journal of Biological Chemistry, 285 (37), 29001-29013. doi: 10.1074/jbc.M110.128454

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18

Yeap, Yvonne Y. C., Ng, Ivan H. W., Badrian, Bahareh, Nguyen, Tuong-Vi, Yip, Yan Y., Dhillon, Amardeep S., Mutsaers, Steven E., Silke, John, Bogoyevitch, Marie A. and Ng, Dominic C. H. (2010). c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18. Biochemical Journal, 430 (2), 345-354. doi: 10.1042/BJ20100425

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

Bogoyevitch, Marie A., Ngoei, Kevin R. W., Zhao, Teresa T., Yeap, Yvonne Y. C. and Ng, Dominic C. H. (2010). c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1804 (3), 463-475. doi: 10.1016/j.bbapap.2009.11.002

SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells

Ng, Dominic C. H., Lim, Cheh P., Lin, Bao H., Zhang, Tong and Cao, Xinmin (2010). SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells. Biochemical Journal, 425 (1), 95-105. doi: 10.1042/BJ20091213

Stat3 promotes directional cell migration by regulating Rac1 activity via its activator βPIX

Teng, Terk Shin, Lin, Baohong, Manser, Ed, Ng, Dominic Chi Hiung and Cao, Xinmin (2009). Stat3 promotes directional cell migration by regulating Rac1 activity via its activator βPIX. Journal of Cell Science, 122 (22), 4150-4159. doi: 10.1242/jcs.057109

Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy

Tsoutsman, Tatiana, Kelly, Matthew, Ng, Dominic C. H., Tan, Ju-En, Tu, Emily, Lam, Lien, Bogoyevitch, Marie A., Seidman, Christine E., Seidman, J. G. and Semsarian, Christopher (2008). Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy. Circulation, 117 (14), 1820-1831. doi: 10.1161/CIRCULATIONAHA.107.755777

Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition

Ng, Dominic C. H., Gebski, Bijanka L., Grounds, Miranda D. and Bogoyevitch, Marie A. (2008). Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition. Cell Motility and the Cytoskeleton, 65 (1), 40-58. doi: 10.1002/cm.20242

Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin

Ng, Dominic Chi Hiung, Lin, Bao Hong, Lim, Cheh Peng, Huang, Guochang, Zhang, Tong, Poli, Valerie and Cao, Xinmin (2006). Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. Journal of Cell Biology, 172 (2), 245-257. doi: 10.1083/jcb.200503021

Small G-protein Rho is involved in the maintenance of cardiac myocyte morphology

Grounds, Haslett R., Ng, Dominic C. H. and Bogoyevitch, Marie A. (2005). Small G-protein Rho is involved in the maintenance of cardiac myocyte morphology. Journal of Cellular Biochemistry, 95 (3), 529-542. doi: 10.1002/jcb.20441

GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I

Huang, Guochang, Lu, Hao, Hao, Aijun, Ng, Dominic C. H., Ponniah, Sathivel, Guo, Ke, Lufei, Chengchen, Zeng, Qi and Cao, Xinmin (2004). GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I. Molecular and Cellular Biology, 24 (19), 8447-8456. doi: 10.1128/MCB.24.19.8447-8456.2004

Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts

Ng, Dominic C.H., Court, Naomi W., Dos Remedios, Cristobal G. and Bogoyevitch, Marie A. (2003). Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts. Cardiovascular Research, 57 (2), 333-346. doi: 10.1016/S0008-6363(02)00664-8

Taking the cell by stealth or storm? Protein Transduction Domains (PTDs) as versatile vectors for delivery

Bogoyevitch, Marie A., Kendrick, Tulene S., Ng, Dominic C.H. and Barr, Renae K. (2002). Taking the cell by stealth or storm? Protein Transduction Domains (PTDs) as versatile vectors for delivery. DNA and Cell Biology, 21 (12), 879-894. doi: 10.1089/104454902762053846

Characterization of Protein Kinases Activated during Treatment of Cells with Okadaic Acid

Bogojevitch, Marie A., Thien, Marilyn and Ng, Dominic C. H. (2001). Characterization of Protein Kinases Activated during Treatment of Cells with Okadaic Acid. Journal of Biochemistry and Molecular Biology, 34 (6), 517-525.

A Role for the Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinases in Interleukin-1β-stimulated Delayed Signal Tranducer and Activator of Transcription 3 Activation, Atrial Natriuretic Factor Expression, and Cardiac Myocyte Morphology

Ng, Dominic C. H., Long, Carlin S. and Bogoyevitch, Marie A. (2001). A Role for the Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinases in Interleukin-1β-stimulated Delayed Signal Tranducer and Activator of Transcription 3 Activation, Atrial Natriuretic Factor Expression, and Cardiac Myocyte Morphology. Journal of Biological Chemistry, 276 (31), 29490-29498. doi: 10.1074/jbc.M100699200

The mechanism of heat shock activation of ERK mitogen-activated protein kinases in the interleukin 3-dependent proB cell line BaF3

Ng, Dominic C. H. and Bogoyevitch, Marie A. (2000). The mechanism of heat shock activation of ERK mitogen-activated protein kinases in the interleukin 3-dependent proB cell line BaF3. Journal of Biological Chemistry, 275 (52), 40856-40866. doi: 10.1074/jbc.M004639200

Intact mitochondrial electron transport function is essential for signalling by hydrogen peroxide in cardiac myocytes

Bogoyevitch, Marie A., Ng, Dominic C.H., Court, Naomi W., Draper, Karen A., Dhillon, Amardeep and Abas, Lindy (2000). Intact mitochondrial electron transport function is essential for signalling by hydrogen peroxide in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 32 (8), 1469-1480. doi: 10.1006/jmcc.2000.1187