The University of Queensland

Defensive-lipid droplets: cellular organelles designed for antimicrobial immunity

Safi, Rémi, Sánchez-Álvarez, Miguel, Bosch, Marta, Demangel, Caroline, Parton, Robert G. and Pol, Albert (2023). Defensive-lipid droplets: cellular organelles designed for antimicrobial immunity. Immunological Reviews, 317 (1), 113-136. doi: 10.1111/imr.13199

Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation

Morales-Paytuví, Frederic, Fajardo, Alba, Ruiz-Mirapeix, Carles, Rae, James, Tebar, Francesc, Bosch, Marta, Enrich, Carlos, Collins, Brett M., Parton, Robert G. and Pol, Albert (2023). Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation. Journal of Cell Biology, 222 (9) e202204020. doi: 10.1083/jcb.202204020

The Role of Membrane Lipids in the Formation and Function of Caveolae

Kenworthy, Anne K., Han, Bing, Ariotti, Nicholas and Parton, Robert G. (2023). The Role of Membrane Lipids in the Formation and Function of Caveolae. Cold Spring Harbor Perspectives in Biology, 15 (9) a041413, a041413. doi: 10.1101/cshperspect.a041413

Caveolae and the oxidative stress response

Wu, Yeping, Lim, Ye-Wheen and Parton, Robert G. (2023). Caveolae and the oxidative stress response. Biochemical Society Transactions, 51 (3), 1377-1385. doi: 10.1042/bst20230121

Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization

Larsson, Elin, Morén, Björn, McMahon, Kerrie-Ann, Parton, Robert G. and Lundmark, Richard (2023). Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization. Journal of Cell Biology, 222 (4) e202205122. doi: 10.1083/jcb.202205122

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2

Wu, Yeping, Lim, Ye-Wheen, Stroud, David A., Martel, Nick, Hall, Thomas E., Lo, Harriet P., Ferguson, Charles, Ryan, Michael T., McMahon, Kerrie-Ann and Parton, Robert G. (2023). Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2. Developmental Cell, 58 (5), 376-397.e4. doi: 10.1016/j.devcel.2023.02.004

Nanoparticle entry into cells; the cell biology weak link

Griffiths, Gareth, Gruenberg, Jean, Marsh, Mark, Wohlmann, Jens, Jones, Arwyn T. and Parton, Robert G. (2022). Nanoparticle entry into cells; the cell biology weak link. Advanced Drug Delivery Reviews, 188 114403, 1-44. doi: 10.1016/j.addr.2022.114403

Volume electron microscopy

Peddie, Christopher J., Genoud, Christel, Kreshuk, Anna, Meechan, Kimberly, Micheva, Kristina D., Narayan, Kedar, Pape, Constantin, Parton, Robert G., Schieber, Nicole L., Schwab, Yannick, Titze, Benjamin, Verkade, Paul, Weigel, Aubrey and Collinson, Lucy M. (2022). Volume electron microscopy. Nature Reviews Methods Primers, 2 (1) 51. doi: 10.1038/s43586-022-00131-9

Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Lo, Harriet P., Lim, Ye-Wheen, Xiong, Zherui, Martel, Nick, Ferguson, Charles, Ariotti, Nicholas, Giacomotto, Jean, Rae, James, Floetenmeyer, Matthias, Moradi, Shayli Varasteh, Gao, Ya, Tillu, Vikas A., Xia, Di, Wang, Huang, Rahnama, Samira, Nixon, Susan J., Bastiani, Michele, Day, Ryan D., Smith, Kelly A., Palpant, Nathan J., Johnston, Wayne A., Alexandrov, Kirill, Collins, Brett M., Hall, Thomas E. and Parton, Robert G. (2021). Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle. Journal of Cell Biology, 220 (12) e201905065. doi: 10.1083/jcb.201905065

Live confocal imaging of zebrafish notochord cells under mechanical stress in vivo

Lim, Ye-Wheen, Lo, Harriet P., Hall, Thomas E. and Parton, Robert G. (2020). Live confocal imaging of zebrafish notochord cells under mechanical stress in vivo. Caveolae: methods and protocols. (pp. 175-187) edited by Cedric M. Blouin. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0732-9_16

Clathrin independent endocytosis

Parton, R. G. (2015). Clathrin independent endocytosis. Encyclopedia of cell biology. (pp. 394-400) edited by Ralph A. Bradshaw and Philip D. Stahl. Kidlington, Oxford, United Kingdom: Elsevier. doi: 10.1016/B978-0-12-394447-4.20039-4

Modern approaches for ultrastructural analysis of the zebrafish embryo

Schieber, Nicole L., Nixon, Susan J., Webb, Richard I., Oorschot, Viola M. J. and Parton, Robert G. (2010). Modern approaches for ultrastructural analysis of the zebrafish embryo. Electron microscopy of model systems. (pp. 425-442) edited by Thomas Müller-Reichert, Leslie Wilson and Paul Matsudaira. Amsterdam, The Netherlands: Academic Press. doi: 10.1016/S0091-679X(10)96018-4

Characterization of Rab23, a negative regulator of sonic hedgehog signaling

Evans, Timothy M., Simpson, Fiona, Parton, Robert G. and Wicking, Carol (2005). Characterization of Rab23, a negative regulator of sonic hedgehog signaling. GTPases regulating membrane targeting and fusion. (pp. 759-777) edited by William E. Balch, Channing J. Der and Alan Hall. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/S0076-6879(05)03066-1

Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience

Brooks, John W., Tillu, Vikas, Eckert, Julia, Verma, Suzie, Collins, Brett M., Parton, Robert G. and Yap, Alpha S. (2023). Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience. Molecular Biology of the Cell, 34 (12) ar120, 1-14. doi: 10.1091/mbc.e23-05-0163

A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

Quiroga, Xarxa, Walani, Nikhil, Disanza, Andrea, Chavero, Albert, Mittens, Alexandra, Tebar, Francesc, Trepat, Xavier, Parton, Robert G, Geli, María Isabel, Scita, Giorgio, Arroyo, Marino, Le Roux, Anabel-Lise and Roca-Cusachs, Pere (2023). A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale. eLife, 12 e72316. doi: 10.7554/elife.72316

Cell surface plasticity in response to shape change in the whole organism

Hall, Thomas E., Ariotti, Nicholas, Lo, Harriet P., Rae, James, Ferguson, Charles, Martel, Nick, Lim, Ye-Wheen, Giacomotto, Jean and Parton, Robert G. (2023). Cell surface plasticity in response to shape change in the whole organism. Current Biology, 33 (19), 4276-4284.e4. doi: 10.1016/j.cub.2023.08.068

Defensive-lipid droplets: cellular organelles designed for antimicrobial immunity

Safi, Rémi, Sánchez-Álvarez, Miguel, Bosch, Marta, Demangel, Caroline, Parton, Robert G. and Pol, Albert (2023). Defensive-lipid droplets: cellular organelles designed for antimicrobial immunity. Immunological Reviews, 317 (1), 113-136. doi: 10.1111/imr.13199

Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation

Morales-Paytuví, Frederic, Fajardo, Alba, Ruiz-Mirapeix, Carles, Rae, James, Tebar, Francesc, Bosch, Marta, Enrich, Carlos, Collins, Brett M., Parton, Robert G. and Pol, Albert (2023). Early proteostasis of caveolins synchronizes trafficking, degradation, and oligomerization to prevent toxic aggregation. Journal of Cell Biology, 222 (9) e202204020. doi: 10.1083/jcb.202204020

The Role of Membrane Lipids in the Formation and Function of Caveolae

Kenworthy, Anne K., Han, Bing, Ariotti, Nicholas and Parton, Robert G. (2023). The Role of Membrane Lipids in the Formation and Function of Caveolae. Cold Spring Harbor Perspectives in Biology, 15 (9) a041413, a041413. doi: 10.1101/cshperspect.a041413

Apicobasal RNA asymmetries regulate cell fate in the early mouse embryo

Hawdon, Azelle, Geoghegan, Niall D., Mohenska, Monika, Elsenhans, Anja, Ferguson, Charles, Polo, Jose M., Parton, Robert G. and Zenker, Jennifer (2023). Apicobasal RNA asymmetries regulate cell fate in the early mouse embryo. Nature Communications, 14 (1) 2909, 1-18. doi: 10.1038/s41467-023-38436-2

Caveolae and the oxidative stress response

Wu, Yeping, Lim, Ye-Wheen and Parton, Robert G. (2023). Caveolae and the oxidative stress response. Biochemical Society Transactions, 51 (3), 1377-1385. doi: 10.1042/bst20230121

Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma membrane nanocluster for synaptic vesicle entry

Joensuu, Merja, Syed, Parnayan, Saber, Saber H., Lanoue, Vanessa, Wallis, Tristan P., Rae, James, Blum, Ailisa, Gormal, Rachel S., Small, Christopher, Sanders, Shanley, Jiang, Anmin, Mahrhold, Stefan, Krez, Nadja, Cousin, Michael A., Cooper‐White, Ruby, Cooper‐White, Justin J., Collins, Brett M., Parton, Robert G., Balistreri, Giuseppe, Rummel, Andreas and Meunier, Frédéric A. (2023). Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma membrane nanocluster for synaptic vesicle entry. The EMBO Journal, 42 (13) e112095, e112095. doi: 10.15252/embj.2022112095

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w

A synthetic organelle approach to probe SNARE-mediated membrane fusion in a bacterial host

Ferreras, Soledad, Singh, Neha Pratap, Leborgne, Remi, Bun, Philippe, Binz, Thomas, Parton, Robert G., Verbavatz, Jean-Marc, Vannier, Christian and Galli, Thierry (2023). A synthetic organelle approach to probe SNARE-mediated membrane fusion in a bacterial host. Journal of Biological Chemistry, 299 (3) 102974. doi: 10.1016/j.jbc.2023.102974

Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts

Ng, Pei Ying, Ribet, Amy B. P., Guo, Qiang, Mullin, Benjamin H., Tan, Jamie W. Y., Landao-Bassonga, Euphemie, Stephens, Sébastien, Chen, Kai, Yuan, Jinbo, Abudulai, Laila, Bollen, Maike, Nguyen, Edward T. T. T., Kular, Jasreen, Papadimitriou, John M., Søe, Kent, Teasdale, Rohan D., Xu, Jiake, Parton, Robert G., Takayanagi, Hiroshi and Pavlos, Nathan J. (2023). Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts. Nature Communications, 14 (1) 906, 1-23. doi: 10.1038/s41467-023-36484-2

Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization

Larsson, Elin, Morén, Björn, McMahon, Kerrie-Ann, Parton, Robert G. and Lundmark, Richard (2023). Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization. Journal of Cell Biology, 222 (4) e202205122. doi: 10.1083/jcb.202205122

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2

Wu, Yeping, Lim, Ye-Wheen, Stroud, David A., Martel, Nick, Hall, Thomas E., Lo, Harriet P., Ferguson, Charles, Ryan, Michael T., McMahon, Kerrie-Ann and Parton, Robert G. (2023). Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2. Developmental Cell, 58 (5), 376-397.e4. doi: 10.1016/j.devcel.2023.02.004

Author Correction: Volume electron microscopy

Peddie, Christopher J., Genoud, Christel, Kreshuk, Anna, Meechan, Kimberly, Micheva, Kristina D., Narayan, Kedar, Pape, Constantin, Parton, Robert G., Schieber, Nicole L., Schwab, Yannick, Titze, Benjamin, Verkade, Paul, Weigel, Aubrey and Collinson, Lucy M. (2022). Author Correction: Volume electron microscopy. Nature Reviews Methods Primers, 2 (1) 72, 1-1. doi: 10.1038/s43586-022-00163-1

Nanoparticle entry into cells; the cell biology weak link

Griffiths, Gareth, Gruenberg, Jean, Marsh, Mark, Wohlmann, Jens, Jones, Arwyn T. and Parton, Robert G. (2022). Nanoparticle entry into cells; the cell biology weak link. Advanced Drug Delivery Reviews, 188 114403, 1-44. doi: 10.1016/j.addr.2022.114403

Hydrocephalus in Nfix−/− mice is underpinned by changes in ependymal cell physiology

Harkins, Danyon, Harvey, Tracey J., Atterton, Cooper, Miller, Ingrid, Currey, Laura, Oishi, Sabrina, Kasherman, Maria, Davila, Raul Ayala, Harris, Lucy, Green, Kathryn, Piper, Hannah, Parton, Robert G., Thor, Stefan, Cooper, Helen M. and Piper, Michael (2022). Hydrocephalus in Nfix−/− mice is underpinned by changes in ependymal cell physiology. Cells, 11 (15) 2377, 2377. doi: 10.3390/cells11152377

Volume electron microscopy

Peddie, Christopher J., Genoud, Christel, Kreshuk, Anna, Meechan, Kimberly, Micheva, Kristina D., Narayan, Kedar, Pape, Constantin, Parton, Robert G., Schieber, Nicole L., Schwab, Yannick, Titze, Benjamin, Verkade, Paul, Weigel, Aubrey and Collinson, Lucy M. (2022). Volume electron microscopy. Nature Reviews Methods Primers, 2 (1) 51. doi: 10.1038/s43586-022-00131-9

The structure of caveolin finally takes shape

Parton, Robert G. and Collins, Brett M. (2022). The structure of caveolin finally takes shape. Science Advances, 8 (19) eabq6985, eabq6985. doi: 10.1126/sciadv.abq6985

βIII-tubulin structural domains regulate mitochondrial network architecture in an isotype-specific manner

Parker, Amelia L., Teo, Wee Siang, Brayford, Simon, Moorthi, Ullhas K., Arumugam, Senthil, Ferguson, Charles, Parton, Robert G., McCarroll, Joshua A. and Kavallaris, Maria (2022). βIII-tubulin structural domains regulate mitochondrial network architecture in an isotype-specific manner. Cells, 11 (5) 776, 776. doi: 10.3390/cells11050776

ContactJ: characterization of lipid droplet-mitochondrial contacts using fluorescence microscopy and image analysis

Martín, Gemma, Calvo, Maria, Bosch, Marta, Coll, Elisenda, Parton, Robert G. and Pol, Albert (2022). ContactJ: characterization of lipid droplet-mitochondrial contacts using fluorescence microscopy and image analysis. F1000Research, 10 263, 1-25. doi: 10.12688/f1000research.51900.2

Publisher Correction: Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis (Nature Cell Biology, (2021), 23, 10, (1073-1084), 10.1038/s41556-021-00767-x)

Moreno-Layseca, Paulina, Jäntti, Niklas Z., Godbole, Rashmi, Sommer, Christian, Jacquemet, Guillaume, Al-Akhrass, Hussein, Conway, James R. W., Kronqvist, Pauliina, Kallionpää, Roosa E., Oliveira-Ferrer, Leticia, Cervero, Pasquale, Linder, Stefan, Aepfelbacher, Martin, Zauber, Henrik, Rae, James, Parton, Robert G., Disanza, Andrea, Scita, Giorgio, Mayor, Satyajit, Selbach, Matthias, Veltel, Stefan and Ivaska, Johanna (2022). Publisher Correction: Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis (Nature Cell Biology, (2021), 23, 10, (1073-1084), 10.1038/s41556-021-00767-x). Nature Cell Biology, 24 (9), 1445-1445. doi: 10.1038/s41556-022-00952-6

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

Goodall, Emily C. A., Isom, Georgia L., Rooke, Jessica L., Pullela, Karthik, Icke, Christopher, Yang, Zihao, Boelter, Gabriela, Jones, Alun, Warner, Isabel, Da Costa, Rochelle, Zhang, Bing, Rae, James, Tan, Wee Boon, Winkle, Matthias, Delhaye, Antoine, Heinz, Eva, Collet, Jean-Francois, Cunningham, Adam F., Blaskovich, Mark A., Parton, Robert G., Cole, Jeff A., Banzhaf, Manuel, Chng, Shu-Sin, Vollmer, Waldemar, Bryant, Jack A. and Henderson, Ian R. (2021). Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth. PLoS Genetics, 17 (12) e1009586, 1-40. doi: 10.1371/journal.pgen.1009586

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

Chen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P, Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby and Collins, Brett M. (2021). De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Science Advances, 7 (49) eabg4007, eabg4007. doi: 10.1126/sciadv.abg4007

High intraluminal pressure promotes vascular inflammation via caveolin-1

Michell, Danielle L., Shihata, Waled A., Andrews, Karen L., Abidin, Nurul Aisha Zainal, Jefferis, Ann-Maree, Sampson, Amanda K., Lumsden, Natalie G., Huet, Olivier, Parat, Marie-Odile, Jennings, Garry L., Parton, Robert G., Woollard, Kevin J., Kaye, David M., Chin-Dusting, Jaye P. F. and Murphy, Andrew J. (2021). High intraluminal pressure promotes vascular inflammation via caveolin-1. Scientific Reports, 11 (1) 5894, 5894. doi: 10.1038/s41598-021-85476-z

Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle

Lamboley, Cedric R., Pearce, Luke, Seng, Crystal, Meizoso-Huesca, Aldo, Singh, Daniel P., Frankish, Barnaby P., Kaura, Vikas, Lo, Harriet P., Ferguson, Charles, Allen, Paul D., Hopkins, Philip M., Parton, Robert G., Murphy, Robyn M., van der Poel, Chris, Barclay, Christopher J. and Launikonis, Bradley S. (2021). Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances, 7 (44) eabi7166, 1-15. doi: 10.1126/sciadv.abi7166

Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

Lo, Harriet P., Lim, Ye-Wheen, Xiong, Zherui, Martel, Nick, Ferguson, Charles, Ariotti, Nicholas, Giacomotto, Jean, Rae, James, Floetenmeyer, Matthias, Moradi, Shayli Varasteh, Gao, Ya, Tillu, Vikas A., Xia, Di, Wang, Huang, Rahnama, Samira, Nixon, Susan J., Bastiani, Michele, Day, Ryan D., Smith, Kelly A., Palpant, Nathan J., Johnston, Wayne A., Alexandrov, Kirill, Collins, Brett M., Hall, Thomas E. and Parton, Robert G. (2021). Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle. Journal of Cell Biology, 220 (12) e201905065. doi: 10.1083/jcb.201905065

An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T)

Yeo, A.J., Subramanian, G.N., Chong, K.L., Gatei, M., Parton, R.G., Coman, D. and Lavin, M.F. (2021). An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Molecular Metabolism, 54 101354, 101354. doi: 10.1016/j.molmet.2021.101354

Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis

Moreno-Layseca, Paulina, Jäntti, Niklas Z., Godbole, Rashmi, Sommer, Christian, Jacquemet, Guillaume, Al-Akhrass, Hussein, Conway, James R. W., Kronqvist, Pauliina, Kallionpää, Roosa E., Oliveira-Ferrer, Leticia, Cervero, Pasquale, Linder, Stefan, Aepfelbacher, Martin, Zauber, Henrik, Rae, James, Parton, Robert G., Disanza, Andrea, Scita, Giorgio, Mayor, Satyajit, Selbach, Matthias, Veltel, Stefan and Ivaska, Johanna (2021). Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis. Nature Cell Biology, 23 (10), 1073-1084. doi: 10.1038/s41556-021-00767-x

Proximity dependent biotin labelling in zebrafish for proteome and interactome profiling

Xiong, Zherui, Lo, Harriet P., McMahon, Kerrie-Ann, Parton, Robert G. and Hall, Thomas E. (2021). Proximity dependent biotin labelling in zebrafish for proteome and interactome profiling. Bio-protocol, 11 (19) e4178, e4178. doi: 10.21769/BIOPROTOC.4178

Publisher Correction: Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis

Sathe, Mugdha, Muthukrishnan, Gayatri, Rae, James, Disanza, Andrea, Thattai, Mukund, Scita, Giorgio, Parton, Robert G. and Mayor, Satyajit (2021). Publisher Correction: Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis. Nature Communications, 12 (1) 5158, 5158. doi: 10.1038/s41467-021-25458-x

Key phases in the formation of caveolae

Parton, Robert G., Tillu, Vikas, McMahon, Kerrie-Ann and Collins, Brett M. (2021). Key phases in the formation of caveolae. Current Opinion in Cell Biology, 71, 7-14. doi: 10.1016/j.ceb.2021.01.009

Nanoscape, a data-driven 3D real-time interactive virtual cell environment

Kadir, Shereen R, Lilja, Andrew, Gunn, Nick, Strong, Campbell, Hughes, Rowan T, Bailey, Benjamin J, Rae, James, Parton, Robert G and McGhee, John (2021). Nanoscape, a data-driven 3D real-time interactive virtual cell environment. eLife, 10 e64047, 1-36. doi: 10.7554/elife.64047

Lipid droplets and the host–pathogen dynamic: FATal attraction?

Bosch, Marta, Sweet, Matthew J., Parton, Robert G. and Pol, Albert (2021). Lipid droplets and the host–pathogen dynamic: FATal attraction?. Journal of Cell Biology, 220 (8) e202104005. doi: 10.1083/jcb.202104005

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

McMahon, Kerrie-Ann, Stroud, David A., Gambin, Yann, Tillu, Vikas, Bastiani, Michele, Sierecki, Emma, Polinkovsky, Mark E., Hall, Thomas E., Gomez, Guillermo A., Wu, Yeping, Parat, Marie-Odile, Martel, Nick, Lo, Harriet P., Khanna, Kum Kum, Alexandrov, Kirill, Daly, Roger, Yap, Alpha, Ryan, Michael T. and Parton, Robert G. (2021). Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. eLife, 10 e61407, 1-35. doi: 10.7554/elife.61407

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Sun, Xuan, Cao, Benjamin, Naval-Sanchez, Marina, Pham, Tony, Sun, Yu Bo Yang, Williams, Brenda, Heazlewood, Shen Y, Deshpande, Nikita, Li, Jinhua, Kraus, Felix, Rae, James, Nguyen, Quan, Yari, Hamed, Schröder, Jan, Heazlewood, Chad K, Fulton, Madeline, Hatwell-Humble, Jessica, Das Gupta, Kaustav, Kapetanovic, Ronan, Chen, Xiaoli, Sweet, Matthew J, Parton, Robert G, Ryan, Michael T, Polo, Jose M, Nefzger, Christian M and Nilsson, Susan K (2021). Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells. Nature Communications, 12 (1) 2665, 1-17. doi: 10.1038/s41467-021-22863-0

A robust method for particulate detection of a genetic tag for 3D electron microscopy

Rae, James, Ferguson, Charles, Ariotti, Nicholas, Webb, Richard I., Cheng, Han-Hao, Mead, James L., Riches, James D., Hunter, Dominic J.B., Martel, Nick, Baltos, Joanne, Christopoulos, Arthur, Bryce, Nicole S., Cagigas, Maria Lastra, Fonseka, Sachini, Sayre, Marcel E., Hardeman, Edna C., Gunning, Peter W., Gambin, Yann, Hall, Thomas E. and Parton, Robert G. (2021). A robust method for particulate detection of a genetic tag for 3D electron microscopy. eLife, 10 e64630, 1-17. doi: 10.7554/eLife.64630

Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer

Robinson, Harley, Ruelcke, Jayde E., Lewis, Amanda, Bond, Charles S., Fox, Archa H., Bharti, Vandhana, Wani, Shivangi, Cloonan, Nicole, Lai, Andrew, Margolin, David, Li, Li, Salomon, Carlos, Richards, Renée S., Farrell, Aine, Gardiner, Robert A., Parton, Robert G., Cristino, Alexandre S. and Hill, Michelle M. (2021). Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer. Clinical and Translational Medicine, 11 (4) e381, e381. doi: 10.1002/ctm2.381

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

Rennick, Joshua J., Johnston, Angus P. R. and Parton, Robert G. (2021). Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics. Nature Nanotechnology, 16 (3), 266-276. doi: 10.1038/s41565-021-00858-8

In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish

Xiong, Zherui, Lo, Harriet P., McMahon, Kerrie-Ann, Martel, Nick, Jones, Alun, Hill, Michelle M., Parton, Robert G. and Hall, Thomas E. (2021). In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish. eLife, 10 e64631, 1-21. doi: 10.7554/elife.64631

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

Tillu, Vikas A., Rae, James, Gao, Ya, Ariotti, Nicholas, Floetenmeyer, Matthias, Kovtun, Oleksiy, McMahon, Kerrie-Ann, Chaudhary, Natasha, Parton, Robert G. and Collins, Brett M. (2021). Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation. Nature Communications, 12 (1) 931, 931. doi: 10.1038/s41467-021-21035-4

Caveolin-1 influences epithelial collective cell migration via FMNL2 formin

Katsuno-Kambe, Hiroko, Parton, Robert G, Yap, Alpha S and Teo, Jessica L (2021). Caveolin-1 influences epithelial collective cell migration via FMNL2 formin. Biology of the Cell, 113 (2), 107-117. doi: 10.1111/boc.202000116

Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion

Duszyc, Kinga, Gomez, Guillermo A., Lagendijk, Anne K., Yau, Mei-Kwan, Nanavati, Bageshri Naimish, Gliddon, Briony L., Hall, Thomas E., Verma, Suzie, Hogan, Benjamin M., Pitson, Stuart M., Fairlie, David P., Parton, Robert G. and Yap, Alpha S. (2021). Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion. Current Biology, 31 (6), 1326-1336.e5. doi: 10.1016/j.cub.2021.01.003

Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae

Zhou, Yong, Ariotti, Nicholas, Rae, James, Liang, Hong, Tillu, Vikas, Tee, Shern, Bastiani, Michele, Bademosi, Adekunle T., Collins, Brett M., Meunier, Frederic A., Hancock, John F. and Parton, Robert G. (2021). Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae. Journal of Cell Biology, 220 (3) e202005138. doi: 10.1083/jcb.202005138

Formation of retromer transport carriers is disrupted by the Parkinson disease‐linked Vps35 D620N variant

Cui, Yi, Yang, Zhe, Flores‐Rodriguez, Neftali, Follett, Jordan, Ariotti, Nicholas, Wall, Adam A., Parton, Robert G. and Teasdale, Rohan D. (2021). Formation of retromer transport carriers is disrupted by the Parkinson disease‐linked Vps35 D620N variant. Traffic, 22 (4) tra.12779, 123-136. doi: 10.1111/tra.12779

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

Yeo, Abrey J., Kok, Chong L., Gatei, Magtouf, Zou, Dongxiu, Stewart, Romal, Withey, Sarah, Wolvetang, Ernst, Parton, Robert G., Brown, Adam D., Kastan, Michael B., Coman, David and Lavin, Martin F. (2021). Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia. iScience, 24 (1) 101972, 101972. doi: 10.1016/j.isci.2020.101972

Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling

Lonic, Ana, Gehling, Freya, Belle, Leila, Li, Xiaochun, Schieber, Nicole L., Nguyen, Elizabeth V., Goodall, Gregory J., Parton, Robert G., Daly, Roger J. and Khew-Goodall, Yeesim (2021). Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling. Journal of Cell Biology, 220 (2) e201902073. doi: 10.1083/jcb.201902073

ContactJ: lipid droplets-mitochondria contacts characterization through fluorescence microscopy and image analysis

Martín, Gemma, Bosch, Marta, Coll, Elisenda, Parton, Robert G., Pol, Albert and Calvo, Maria (2021). ContactJ: lipid droplets-mitochondria contacts characterization through fluorescence microscopy and image analysis. F1000Research, 10 263. doi: 10.12688/f1000research.51900.1

Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner

Abbasi, Mojdeh, Gupta, Vivek K., Chitranshi, Nitin, Gupta, Veer, Ranjbaran, Reza, Rajput, Rashi, Pushpitha, Kanishka, Devaraj, K. B., You, Yuyi, Salekdeh, Ghasem Hosseini, Parton, Robert G., Mirzaei, Mehdi and Graham, Stuart L. (2021). Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner. Theranostics, 11 (13), 6154-6172. doi: 10.7150/thno.55472

A new direction for Traffic

Marks, Michael S., Parton, Robert G., Schroer, Trina A., Tooze, Sharon A., Brodsky, Frances M., Marsh, Mark, Schmid, Sandra L., Griffiths, Gillian M., Stevens, Tom H. and van Meer, Gerrit (2020). A new direction for Traffic. Traffic, 21 (12), 724-724. doi: 10.1111/tra.12763

Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies

Gormal, Rachel S., Padmanabhan, Pranesh, Kasula, Ravikiran, Bademosi, Adekunle T., Coakley, Sean, Giacomotto, Jean, Blum, Ailisa, Joensuu, Merja, Wallis, Tristan P., Lo, Harriet P., Budnar, Srikanth, Rae, James, Ferguson, Charles, Bastiani, Michele, Thomas, Walter G., Pardon, Els, Steyaert, Jan, Yap, Alpha S., Goodhill, Geoffrey J., Hilliard, Massimo A., Parton, Robert G. and Meunier, Frédéric A. (2020). Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies. Proceedings of the National Academy of Sciences of the United States of America, 117 (48), 30476-30487. doi: 10.1073/pnas.2007443117

Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion

Teo, Jessica L, Tomatis, Vanesa M, Coburn, Luke, Lagendijk, Anne K, Schouwenaar, Irin-Maya, Budnar, Srikanth, Hall, Thomas E, Verma, Suzie, McLachlan, Robert W, Hogan, Benjamin M, Parton, Robert G, Yap, Alpha S and Gomez, Guillermo A (2020). Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion. Molecular Biology of the Cell, 31 (23), 2495-2629. doi: 10.1091/mbc.E20-01-0084

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

Bosch, Marta, Sánchez-Álvarez, Miguel, Fajardo, Alba, Kapetanovic, Ronan, Steiner, Bernhard, Dutra, Filipe, Moreira, Luciana, López, Juan Antonio, Campo, Rocío, Marí, Montserrat, Morales-Paytuví, Frederic, Tort, Olivia, Gubern, Albert, Templin, Rachel M., Curson, James E. B., Martel, Nick, Català, Cristina, Lozano, Francisco, Tebar, Francesc, Enrich, Carlos, Vázquez, Jesús, Del Pozo, Miguel A., Sweet, Matthew J., Bozza, Patricia T., Gross, Steven P., Parton, Robert G. and Pol, Albert (2020). Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense. Science, 370 (6514) 8085, 309-+. doi: 10.1126/science.aay8085

An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells

Ariotti, Nicholas, Wu, Yeping, Okano, Satomi, Gambin, Yann, Follett, Jordan, Rae, James, Ferguson, Charles, Teasdale, Rohan D., Alexandrov, Kirill, Meunier, Frederic A., Hill, Michelle M. and Parton, Robert G. (2020). An inverted CAV1 (caveolin 1) topology defines novel autophagy-dependent exosome secretion from prostate cancer cells. Autophagy, 17 (9), 1-17. doi: 10.1080/15548627.2020.1820787

Role for caveolin-mediated transcytosis in facilitating transport of large cargoes into the brain via ultrasound

Pandit, Rucha, Koh, Wee Kiat, Sullivan, Robert K.P., Palliyaguru, Tishila, Parton, Robert G. and Götz, Jürgen (2020). Role for caveolin-mediated transcytosis in facilitating transport of large cargoes into the brain via ultrasound. Journal of Controlled Release, 327, 667-675. doi: 10.1016/j.jconrel.2020.09.015

Caveolae: Formation, dynamics, and function

Parton, Robert G., McMahon, Kerrie-Ann and Wu, Yeping (2020). Caveolae: Formation, dynamics, and function. Current Opinion in Cell Biology, 65, 8-16. doi: 10.1016/j.ceb.2020.02.001

In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation

Hall, Thomas E., Martel, Nick, Ariotti, Nicholas, Xiong, Zherui, Lo, Harriet P., Ferguson, Charles, Rae, James, Lim, Ye-Wheen and Parton, Robert G. (2020). In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation. Nature Communications, 11 (1) 3711, 3711. doi: 10.1038/s41467-020-17486-w

Caveolin-1 ablation imparts partial protection against inner retinal injury in experimental glaucoma and reduces apoptotic activation

Abbasi, Mojdeh, Gupta, Vivek K., Chitranshi, Nitin, Gupta, Veer B., Mirzaei, Mehdi, Dheer, Yogita, Garthwaite, Linda, Zaw, Thiri, Parton, Robert G., You, Yuyi and Graham, Stuart L. (2020). Caveolin-1 ablation imparts partial protection against inner retinal injury in experimental glaucoma and reduces apoptotic activation. Molecular Neurobiology, 57 (9), 3759-3784. doi: 10.1007/s12035-020-01948-9

Frontline Science: LPS‐inducible SLC30A1 drives human macrophage‐mediated zinc toxicity against intracellular Escherichia coli

Stocks, Claudia J., Pein, Jessica B., Curson, James E.B., Rae, James, Phan, Minh‐Duy, Foo, Darren, Bokil, Nilesh J., Kambe, Taiho, Peters, Kate M., Parton, Robert G., Schembri, Mark A., Kapetanovic, Ronan and Sweet, Matthew J. (2020). Frontline Science: LPS‐inducible SLC30A1 drives human macrophage‐mediated zinc toxicity against intracellular Escherichia coli. Journal of Leukocyte Biology, 109 (2) JLB.2HI0420-160R, 287-297. doi: 10.1002/jlb.2hi0420-160r

Novel contact sites between lipid droplets, early endosomes, and the endoplasmic reticulum

Parton, Robert G., Bosch, Marta, Steiner, Bernhard and Pol, Albert (2020). Novel contact sites between lipid droplets, early endosomes, and the endoplasmic reticulum. Journal of Lipid Research, 61 (11), jlr.ILR120000876-1364. doi: 10.1194/jlr.ilr120000876

Non-caveolar caveolins - duties outside the caves

Pol, Albert, Morales-Paytuví, Frederic, Bosch, Marta and Parton, Robert G. (2020). Non-caveolar caveolins - duties outside the caves. Journal of Cell Science, 133 (9) jcs241562, jcs241562. doi: 10.1242/jcs.241562

Growth hormone stops excessive inflammation after partial hepatectomy allowing liver regeneration and survival via induction of H2-Bl/HLA-G

Ishikawa, Mayumi, Brooks, Andrew J., Fernández-Rojo, Manuel A., Medina, Johan, Chhabra, Yash, Minami, Shiro, Tunny, Kathryn A., Parton, Robert G., Vivian, Julian P., Rossjohn, Jamie, Chikani, Viral, Ramm, Grant A., Ho, Ken K. Y. and Waters, Michael J. (2020). Growth hormone stops excessive inflammation after partial hepatectomy allowing liver regeneration and survival via induction of H2-Bl/HLA-G. Hepatology, 73 (2) hep.31297, 759-775. doi: 10.1002/hep.31297

Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

Bywater, Megan J., Burkhart, Deborah L., Straube, Jasmin, Sabò, Arianna, Pendino, Vera, Hudson, James E., Quaife-Ryan, Gregory A., Porrello, Enzo R., Rae, James, Parton, Robert G., Kress, Theresia R., Amati, Bruno, Littlewood, Trevor D., Evan, Gerard I. and Wilson, Catherine H. (2020). Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity. Nature Communications, 11 (1) 1827, 1827. doi: 10.1038/s41467-020-15552-x

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019

Caveolae and lipid sorting: shaping the cellular response to stress

Parton, Robert G., Kozlov, Michael M. and Ariotti, Nicholas (2020). Caveolae and lipid sorting: shaping the cellular response to stress. Journal of Cell Biology, 219 (4) e201905071. doi: 10.1083/jcb.201905071

Mapping interactions among cell-free expressed Zirka virus proteins

Varasteh Moradi, Shayli, Gagoski, Dejan, Mureev, Sergey, Walden, Patricia, McMahon, Kerrie-Ann, Parton, Robert G., Johnston, Wayne A. and Alexandrov, Kirill (2020). Mapping interactions among cell-free expressed Zirka virus proteins. Journal of Proteome Research, 19 (4) acs.jproteome.9b00771, 1522-1532. doi: 10.1021/acs.jproteome.9b00771

A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure

Pu, Wenjun, Qiu, Jiawen, Nassar, Zeyad D., Shaw, Paul N., McMahon, Kerrie‐Ann, Ferguson, Charles, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie‐Odile (2020). A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure. Journal of Cellular and Molecular Medicine, 24 (6) jcmm.15076, 3724-3738. doi: 10.1111/jcmm.15076

The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development

Shohayeb, Belal, Ho, Uda, Yeap, Yvonne Y., Parton, Robert G., Millard, Sean S., Xu, Zhiheng, Piper, Michael and Ng, Dominic C. H. (2020). The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. Human Molecular Genetics, 29 (2), 248-263. doi: 10.1093/hmg/ddz281

Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis

Bhattachan, Punit, Rae, James, Yu, Haiyan, Jung, WooRam, Wei, Jiankai, Parton, Robert G. and Dong, Bo (2020). Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis. The FASEB Journal, 34 (1), 1345-1361. doi: 10.1096/fj.201901281R

Caveolae control contractile tension for epithelia to eliminate tumor cells

Teo, Jessica L., Gomez, Guillermo A., Weeratunga, Saroja, Davies, Elizabeth M., Noordstra, Ivar, Budnar, Srikanth, Katsuno-Kambe, Hiroko, McGrath, Meagan J., Verma, Suzie, Tomatis, Vanesa, Acharya, Bipul R., Balasubramaniam, Lakshmi, Templin, Rachel M., McMahon, Kerrie-Ann, Lee, Yoke Seng, Ju, Robert J., Stebhens, Samantha J., Ladoux, Benoit, Mitchell, Christina A., Collins, Brett M., Parton, Robert G. and Yap, Alpha S. (2020). Caveolae control contractile tension for epithelia to eliminate tumor cells. Developmental Cell, 54 (1), 75-91.e7. doi: 10.1016/j.devcel.2020.05.002

Lipid droplets, bioenergetic fluxes, and metabolic flexibility

Bosch, Marta, Parton, Robert G. and Pol, Albert (2020). Lipid droplets, bioenergetic fluxes, and metabolic flexibility. Seminars in Cell and Developmental Biology, 108, 33-46. doi: 10.1016/j.semcdb.2020.02.010

ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets

Du, Ximing, Zhou, Linkang, Aw, Yvette Celine, Mak, Hoi Yin, Xu, Yanqing, Rae, James, Wang, Wenmin, Zadoorian, Armella, Hancock, Sarah E., Osborne, Brenna, Chen, Xiang, Wu, Jia-Wei, Turner, Nigel, Parton, Robert G., Li, Peng and Yang, Hongyuan (2020). ORP5 localizes to ER–lipid droplet contacts and regulates the level of PI(4)P on lipid droplets. The Journal of Cell Biology, 219 (1) jcb.201905162. doi: 10.1083/jcb.201905162

Twenty years of Traffic

Marks, Michael S., Tooze, Sharon A., Brodsky, Frances M., Marsh, Mark, Parton, Robert G. and Schroer, Trina A. (2020). Twenty years of Traffic. Traffic, 21 (1), 4-5. doi: 10.1111/tra.12688

An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation

Echarri, Asier, Pavón, Dácil M., Sánchez, Sara, García-García, María, Calvo, Enrique, Huerta-López, Carla, Velázquez-Carreras, Diana, Viaris de Lesegno, Christine, Ariotti, Nicholas, Lázaro-Carrillo, Ana, Strippoli, Raffaele, De Sancho, David, Alegre-Cebollada, Jorge, Lamaze, Christophe, Parton, Robert G. and Del Pozo, Miguel A. (2019). An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation. Nature Communications, 10 (1) 5828, 1-16. doi: 10.1038/s41467-019-13782-2

Caveolae: the FAQs

Parton, Robert G., Pozo, Miguel A., Vassilopoulos, Stéphane, Nabi, Ivan R., Le Lay, Soazig, Lundmark, Richard, Kenworthy, Anne K., Camus, Anne, Blouin, Cedric M., Sessa, William C. and Lamaze, Christophe (2019). Caveolae: the FAQs. Traffic, 21 (1) tra.12689, 181-185. doi: 10.1111/tra.12689

20 years of Traffic: a 2020 vision of cellular electron microscopy

Parton, Robert G (2019). 20 years of Traffic: a 2020 vision of cellular electron microscopy. Traffic, 21 (1) tra.12684, 156-161. doi: 10.1111/tra.12684

Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres

Meiring, Joyce C. M., Bryce, Nicole S., Cagigas, Maria Lastra, Benda, Aleš, Whan, Renee M., Ariotti, Nicholas, Parton, Robert G., Stear, Jeffrey H., Hardeman, Edna C. and Gunning, Peter W. (2019). Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres. Journal of Cell Science, 132 (15) jcs228916, jcs.228916. doi: 10.1242/jcs.228916

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

McMahon, Kerrie-Ann, Wu, Yeping, Gambin, Yann, Sierecki, Emma, Tillu, Vikas A., Hall, Thomas, Martel, Nick, Okano, Satomi, Moradi, Shayli Varasteh, Ruelcke, Jayde E., Ferguson, Charles, Yap, Alpha S., Alexandrov, Kirill, Hill, Michelle M. and Parton, Robert G. (2019). Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis. Nature Communications, 10 (1) 3279, 3279. doi: 10.1038/s41467-019-11111-1

The membrane environment of cadherin adhesion receptors: a working hypothesis

Teo, Jessica L., Parton, Robert G. and Yap, Alpha S. (2019). The membrane environment of cadherin adhesion receptors: a working hypothesis. Biochemical Society Transactions, 47 (4), BST20180012-995. doi: 10.1042/bst20180012

Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice

Moreau, Dimitri, Vacca, Fabrizio, Vossio, Stefania, Scott, Cameron, Colaco, Alexandria, Paz Montoya, Jonathan, Ferguson, Charles, Damme, Markus, Moniatte, Marc, Parton, Robert G, Platt, Frances M and Gruenberg, Jean (2019). Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice. EMBO Reports, 20 (7) e47055, e47055. doi: 10.15252/embr.201847055

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

Pu, Wenjun, Nassar, Zeyad D., Khabbazi, Samira, Xie, Nan, McMahon, Kerrie-Ann, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie-Odile (2019). Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1. Journal of Neuro-Oncology, 143 (2), 207-220. doi: 10.1007/s11060-019-03161-8

Development of a human skeletal micro muscle platform with pacing capabilities

Mills, Richard J., Parker, Benjamin L., Monnot, Pauline, Needham, Elise. J., Vivien, Celine J., Ferguson, Charles, Parton, Robert G., James, David E., Porrello, Enzo R. and Hudson, James E. (2019). Development of a human skeletal micro muscle platform with pacing capabilities. Biomaterials, 198, 217-227. doi: 10.1016/j.biomaterials.2018.11.030

Membrane curvature and tension control the formation and collapse of caveolar superstructures

Golani, Gonen, Ariotti, Nicholas, Parton, Robert G. and Kozlov, Michael M. (2019). Membrane curvature and tension control the formation and collapse of caveolar superstructures. Developmental Cell, 48 (4), 523-538.e4. doi: 10.1016/j.devcel.2018.12.005

Myosin Vb is required for correct trafficking of N-cadherin and cardiac chamber ballooning

Grassini, Daniela R., Da Silva, Jason, Hall, Thomas E., Baillie, Gregory J., Simons, Cas, Parton, Robert G., Hogan, Benjamin M. and Smith, Kelly A. (2019). Myosin Vb is required for correct trafficking of N-cadherin and cardiac chamber ballooning. Developmental Dynamics, 248 (4) dvdy.19, 284-295. doi: 10.1002/dvdy.19

ORP2 delivers cholesterol to the plasma membrane in exchange for phosphatidylinositol 4, 5-bisphosphate (PI(4,5)P2)

Wang, Huan, Ma, Qianli, Qi, Yanfei, Dong, Jiangqing, Du, Ximing, Rae, James, Wang, Jue, Wu, Wei-Feng, Brown, Andrew J., Parton, Robert G., Wu, Jia-Wei and Yang, Hongyuan (2019). ORP2 delivers cholesterol to the plasma membrane in exchange for phosphatidylinositol 4, 5-bisphosphate (PI(4,5)P2). Molecular Cell, 73 (3), 458-473. doi: 10.1016/j.molcel.2018.11.014

Faceted polymersomes: a sphere-to-polyhedron shape transformation

Wong, Chin Ken, Martin, Adam D., Floetenmeyer, Matthias, Parton, Robert G., Stenzel, Martina H. and Thordarson, Pall (2019). Faceted polymersomes: a sphere-to-polyhedron shape transformation. Chemical Science, 10 (9), 2725-2731. doi: 10.1039/c8sc04206c

Retromer has a selective function in cargo sorting via endosome transport carriers

Cui, Yi, Carosi, Julian M., Yang, Zhe, Ariotti, Nicholas, Kerr, Markus C., Parton, Robert G., Sargeant, Timothy J. and Teasdale, Rohan D. (2018). Retromer has a selective function in cargo sorting via endosome transport carriers. The Journal of Cell Biology, 218 (2), jcb.201806153-631. doi: 10.1083/jcb.201806153

Electron microscopic detection of proteins and protein complexes in mammalian cells using APEX-tagged, conditionally stable nanobodies

Hall, Thomas E., Rae, James, Ariotti, Nicholas and Parton, Robert G. (2018). Electron microscopic detection of proteins and protein complexes in mammalian cells using APEX-tagged, conditionally stable nanobodies. Bio-Protocol, 8 (22), e3088. doi: 10.21769/BioProtoc.3088

Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells

Thottacherry, Joseph Jose, Joanna Kosmalska, Anita, Kumar, Amit, Vishen, Amit Singh, Elosegui-Artola, Alberto, Pradhan, Susav, Sharma, Sumit, Singh, Parvinder P., Guadamillas, Marta C., Chaudhary, Natasha, Vishwakarma, Ram, Trepat, Xavier, del Pozo, Miguel A., Parton, Robert G., Rao, Madan, Pullarkat, Pramod, Roca-Cusachs, Pere and Mayor, Satyajit (2018). Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells. Nature Communications, 9 (1) 4217, 4217. doi: 10.1038/s41467-018-06738-5

Caveolae: structure, function, and relationship to disease

Parton, Robert G. (2018). Caveolae: structure, function, and relationship to disease. Annual Review of Cell and Developmental Biology, 34 (1), 111-136. doi: 10.1146/annurev-cellbio-100617-062737

Minimum information reporting in bio–nano experimental literature

Faria, Matthew, Björnmalm, Mattias, Thurecht, Kristofer J., Kent, Stephen J., Parton, Robert G., Kavallaris, Maria, Johnston, Angus P. R., Gooding, J. Justin, Corrie, Simon R., Boyd, Ben J., Thordarson, Pall, Whittaker, Andrew K., Stevens, Molly M., Prestidge, Clive A., Porter, Christopher J. H., Parak, Wolfgang J., Davis, Thomas P., Crampin, Edmund J. and Caruso, Frank (2018). Minimum information reporting in bio–nano experimental literature. Nature Nanotechnology, 13 (9), 777-785. doi: 10.1038/s41565-018-0246-4

A variable undecad repeat domain in cavin1 regulates caveola formation and stability

Tillu, Vikas A., Lim, Ye-Wheen, Kovtun, Oleksiy, Mureev, Sergey, Ferguson, Charles, Bastiani, Michele, McMahon, Kerrie-Ann, Lo, Harriet P., Hall, Thomas E., Alexandrov, Kirill, Collins, Brett M. and Parton, Robert G. (2018). A variable undecad repeat domain in cavin1 regulates caveola formation and stability. EMBO Reports, 19 (9) e45775. doi: 10.15252/embr.201845775

Correction: Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways (PLoS ONE (2014) 9, 6 (e100554) DOI:10.1371/journal.pone.0100554)

Gupta, Gagan D., Dey, Gautam, Swetha, M. G., Ramalingam, Balaji, Shameer, Khader, Thottacherry, Joseph Jose, Kalappurakkal, Joseph Mathew, Howes, Mark T., Chandran, Ruma, Das, Anupam, Menon, Sindhu, Parton, Robert G., Sowdhamini, R., Thattai, Mukund and Mayor, Satyajit (2018). Correction: Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways (PLoS ONE (2014) 9, 6 (e100554) DOI:10.1371/journal.pone.0100554). PLoS One, 13 (9) e0204770. doi: 10.1371/journal.pone.0204770

Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis

Sathe, Mugdha, Muthukrishnan, Gayatri, Rae, James, Disanza, Andrea, Thattai, Mukund, Scita, Giorgio, Parton, Robert G and Mayor, Satyajit (2018). Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis. Nature Communications, 9 (1) 1835, 1835. doi: 10.1038/s41467-018-03955-w

Cell-free formation and interactome analysis of caveolae

Jung, WooRam, Sierecki, Emma, Bastiani, Michele, O'Carroll, Ailis, Alexandrov, Kirill, Rae, James, Johnston, Wayne, Hunter, Dominic J. B., Ferguson, Charles, Gambin, Yann, Ariotti, Nicholas and Parton, Robert G. (2018). Cell-free formation and interactome analysis of caveolae. The Journal of Cell Biology, 217 (6), 2141-2165. doi: 10.1083/jcb.201707004

Caveolae

Parton, Robert G, Tillu, Vikas A and Collins, Brett M (2018). Caveolae. Current Biology, 28 (8), R402-R405. doi: 10.1016/j.cub.2017.11.075

Ultrastructural localisation of protein interactions using conditionally stable nanobodies

Ariotti, Nicholas, Rae, James, Giles, Nichole, Martel, Nick, Sierecki, Emma, Gambin, Yann, Hall, Thomas E. and Parton, Robert G. (2018). Ultrastructural localisation of protein interactions using conditionally stable nanobodies. PLoS Biology, 16 (4) e2005473, e2005473. doi: 10.1371/journal.pbio.2005473

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria

Hsu, FoSheng, Spannl, Stephanie, Ferguson, Charles, Hyman, Anthony A., Parton, Robert G. and Zerial, Marino (2018). Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. eLife, 7 e32282, 1-37. doi: 10.7554/eLife.32282

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

Xu, Dijin, Li, Yuqi, Wu, Lizhen, Li, Ying, Zhao, Dongyu, Yu, Jinhai, Huang, Tuozhi, Ferguson, Charles, Parton, Robert G., Yang, Hongyuan and Li, Peng (2018). Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions. The Journal of Cell Biology, 217 (3), 975-995. doi: 10.1083/jcb.201704184

Author Correction: tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1

Liang, Xuan, Budnar, Srikanth, Gupta, Shafali, Verma, Suzie, Han, Siew-Ping, Hill, Michelle M., Daly, Roger J, Parton, Robert G., Hamilton, Nicholas A., Gomez, Guillermo A. and Yap, Alpha S. (2017). Author Correction: tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1. Nature Communications, 8 (2021) 2021, 2021. doi: 10.1038/s41467-017-02131-w

Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1

Liang, Xuan, Budnar, Srikanth, Gupta, Shafali, Verma, Suzie, Han, Siew-Ping, Hill, Michelle M., Daly, Roger J., Parton, Robert G., Hamilton, Nicholas A., Gomez, Guillermo A. and Yap, Alpha S. (2017). Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1. Nature Communications, 8 (1) 790, 790. doi: 10.1038/s41467-017-00797-w

Journey to the centre of the cell: Virtual reality immersion into scientific data

Johnston, Angus P. R., Rae, James, Ariotti, Nicholas, Bailey, Benjamin, Lija, Andrew, Webb, Robyn, Ferguson, Charles, Maher, Sheryl, Davis, Thomas P., Webb, Richard I., McGhee, John and Parton, Robert G. (2017). Journey to the centre of the cell: Virtual reality immersion into scientific data. Traffic (Copenhagen, Denmark), 19 (2), 105-110. doi: 10.1111/tra.12538

A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer

Lin, Hui-Ming, Mahon, Kate L, Weir, Jacquelyn M, Mundra, Piyushkumar A, Spielman, Calan, Briscoe, Karen, Gurney, Howard, Mallesara, Girish, Marx, Gavin, Stockler, Martin R, PRIMe Consortium, Parton, Robert G, Hoy, Andrew J, Daly, Roger J, Meikle, Peter J and Horvath, Lisa G (2017). A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer. International Journal of Cancer, 141 (10), 2112-2120. doi: 10.1002/ijc.30903

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R. and Hudson, James E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proceedings of the National Academy of Sciences of the United States of America, 114 (40), E8372-E8381. doi: 10.1073/pnas.1707316114

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

Ghai, Rajesh, Du, Ximing, Wang, Huan, Dong, Jiangqing, Ferguson, Charles, Brown, Andrew J., Parton, Robert G., Wu, Jia-Wei and Yang, Hongyuan (2017). ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane. Nature Communications, 8 (1) 757, 757. doi: 10.1038/s41467-017-00861-5

Caveolin 1 restricts Group A Streptococcus invasion of nonphagocytic host cells

Lim, Jin Yan, Barnett, Timothy C., Bastiani, Michele, McMahon, Kerrie-Ann, Ferguson, Charles, Webb, Richard I., Parton, Robert G. and Walker, Mark J. (2017). Caveolin 1 restricts Group A Streptococcus invasion of nonphagocytic host cells. Cellular microbiology, 19 (12) e12772, 1-16. doi: 10.1111/cmi.12772

A microtubule-organizing center directing intracellular transport in the early mouse embryo

Zenker, J., White, M. D., Templin, R. M., Parton, R. G., Thorn-Seshold, O., Bissiere, S. and Plachta, N. (2017). A microtubule-organizing center directing intracellular transport in the early mouse embryo. Science, 357 (6354), 925-928. doi: 10.1126/science.aam9335

Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane

Hirama, Takashi, Das, Raibatak, Yang, Yanbo, Ferguson, Charles, Won, Amy, Yip, Christopher M., Kay, Jason G., Grinstein, Sergio, Parton, Robert G. and Fairn, Gregory D. (2017). Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane. Journal of Biological Chemistry, 292 (34), 14292-14307. doi: 10.1074/jbc.M117.791400

Akinetic view of GPCR allostery and biased agonism

Lane, J. Robert, May, Lauren T., Parton, Robert G., Sexton, Patrick M. and Christopoulos, Arthur (2017). Akinetic view of GPCR allostery and biased agonism. Nature Chemical Biology, 13 (9), 929-937. doi: 10.1038/nchembio.2431

Caveolae protect notochord cells against catastrophic mechanical failure during development

Lim, Ye-Wheen, Lo, Harriet P., Ferguson, Charles, Martel, Nick, Giacomotto, Jean, Gomez, Guillermo A., Yap, Alpha S., Hall, Thomas E. and Parton, Robert G. (2017). Caveolae protect notochord cells against catastrophic mechanical failure during development. Current Biology, 27 (13), 1968-1981.e7. doi: 10.1016/j.cub.2017.05.067

Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity

Kaakinen, Mika, Reichelt, Melissa E., Ma, Zhibin, Ferguson, Charles, Martel, Nick, Porrello, Enzo R., Hudson, James E., Thomas, Walter G., Parton, Robert G. and Headrick, John P. (2017). Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity. Basic Research in Cardiology, 112 (3) 24, 24. doi: 10.1007/s00395-017-0613-6

Correlative light and electron microscopic detection of GFP-labeled proteins using modular APEX

Ariotti, Nicholas, Hall, Thomas E. and Parton, Robert G. (2017). Correlative light and electron microscopic detection of GFP-labeled proteins using modular APEX. Methods in Cell Biology, 140, 105-121. doi: 10.1016/bs.mcb.2017.03.002

Mammalian diaphanous 1 mediates a pathway for E-cadherin to stabilize epithelial barriers through junctional contractility

Acharya, Bipul R., Wu, Selwin K., Lieu, Zi Zhao, Parton, Robert G., Grill, Stephan W., Bershadsky, Alexander D., Gomez, Guillermo A. and Yap, Alpha S. (2017). Mammalian diaphanous 1 mediates a pathway for E-cadherin to stabilize epithelial barriers through junctional contractility. Cell Reports, 18 (12), 2854-2867. doi: 10.1016/j.celrep.2017.02.078

Development of a human cardiac organoid injury model reveals innate regenerative potential

Voges, Holly K., Mills, Richard J., Elliott, David A., Parton, Robert G., Porrello, Enzo R. and Hudson, James E. (2017). Development of a human cardiac organoid injury model reveals innate regenerative potential. Development, 144 (6), 1118-1127. doi: 10.1242/dev.143966

Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis

Kerr, Markus C., Gomez, Guillermo A., Ferguson, Charles, Tanzer, Maria C., Murphy, James M., Yap, Alpha S., Parton, Robert G., Huston, Wilhelmina M. and Teasdale, Rohan D. (2017). Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis. Nature Communications, 8 (1) 14729, 14729. doi: 10.1038/ncomms14729

A plasmid library of full-length zebrafish rab proteins forcell biology

Hall, Thomas E., Martel, Nick, Lo, Harriet P., Xiong, Zherui and Parton, Robert G. (2017). A plasmid library of full-length zebrafish rab proteins forcell biology. Cellular Logistics, 7 (1), 1-5. doi: 10.1080/21592799.2017.1301151

Unraveling the architecture of caveolae

Parton, Robert G. and Collins, Brett M. (2016). Unraveling the architecture of caveolae. Proceedings of the National Academy of Sciences, 113 (50), 14170-14172. doi: 10.1073/pnas.1617954113

Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence

Sierecki, Emma, Giles, Nichole, Bowden, Quill, Polinkovsky, Mark E., Steinbeck, Janina, Arrioti, Nicholas, Rahman, Diya, Bhumkar, Akshay, Nicovich, Philip R., Ross, Ian, Parton, Robert G., Bocking, Till and Gambin, Yann (2016). Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence. Scientific Reports, 6 (1) 37630, 37630. doi: 10.1038/srep37630

Erratum: Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Pageon, Sophie V. , Tabarin, Thibault , Yamamoto, Yui , Ma, Yuanqing , Nicovich, Philip R. , Bridgeman, John S. , Cohnen, André , Benzing, Carola , Gao, Yijun , Crowther, Michael D. , Tungatt, Katie , Dolton, Garry , Sewell, Andrew K. , Price, David A. , Acuto, Oreste , Parton, Robert G. , Gooding, Justin , Rossy, Jérémie, Rossjohn, Jamie and Gaus, Katharina (2016). Erratum: Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences of the United States of America , 113 (44), e6905-e6905. doi: 10.1073/pnas.1615763113

SEIPIN regulates lipid droplet expansion and adipocyte development by modulating the activity of glycerol-3-phosphate acyltransferase

Pagac, Martin, Cooper, Daniel E., Qi, Yanfei, Lukmantara, Ivan E., Mak, Hoi Yin, Wu, Zengying, Tian, Yuan, Liu, Zhonghua, Lei, Mona, Du, Ximing, Ferguson, Charles, Kotevski, Damian, Sadowski, Pawel, Chen, Weiqin, Boroda, Salome, Harris, Thurl E., Liu, George, Parton, Robert G., Huang, Xun, Coleman, Rosalind A. and Yang, Hongyuan (2016). SEIPIN regulates lipid droplet expansion and adipocyte development by modulating the activity of glycerol-3-phosphate acyltransferase. Cell Reports, 17 (6), 1546-1559. doi: 10.1016/j.celrep.2016.10.037

Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles

Joensuu, Merja, Padmanabhan, Pranesh, Durisic, Nela, Bademosi, Adekunle T. D., Cooper-Williams, Elizabeth, Morrow, Isabel C., Harper, Callista B., Jung, WooRam, Parton, Robert G., Goodhill, Geoffrey J., Papadopulos, Andreas and Meunier, Frederic A. (2016). Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles. Journal of Cell Biology, 215 (2), 277-292. doi: 10.1083/jcb.201604001

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016). Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. The Journal of Cell Biology, 214 (6) 705, 705-718. doi: 10.1083/jcb.201512016

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Pageon, Sophie V., Tabarin, Thibault, Yamamoto, Yui, Ma, Yuangqing, Nicovich, Philip R., Bridgeman, John S., Cohnen, André, Benzing, Carola, Gao, Yijun, Crowther, Michael D., Tungatt, Katie, Dolton, Garry, Sewell, Andrew K., Price, David A., Acuto, Oreste, Parton, Robert G., Gooding, J. Justin, Rossy, Jérémie, Rossjohn, Jamie and Gaus, Katharina (2016). Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences of the United States of America, 113 (37), E5454-E5463*. doi: 10.1073/pnas.1607436113

Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation

Follett, Jordan, Bugarcic, Andrea, Yang, Zhe, Ariotti, Nicholas, Norwood, Suzanne J., Collins, Brett M., Parton, Robert G. and Teasdale, Rohan D. (2016). Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation. Journal of Biological Chemistry, 291 (35), 18283-18298. doi: 10.1074/jbc.M115.703157

An endosomal tether undergoes an entropic collapse to bring vesicles together

Murray, David H., Jahnel, Marcus, Lauer, Janelle, Avellaneda, Mario J., Brouilly, Nicolas, Cezanne, Alice, Morales-Navarrete, Hernan, Perini, Enrico D., Ferguson, Charles, Lupas, Andrei N., Kalaidzidis, Yannis, Parton, Robert G., Grill, Stephan W. and Zerial, Marino (2016). An endosomal tether undergoes an entropic collapse to bring vesicles together. Nature, 537 (7618), 107-111. doi: 10.1038/nature19326

Corrigendum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Takasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., Lopes, Susana M. Chuva de Sousa and Little, Melissa H. (2016). Corrigendum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 536 (7615), 238-238. doi: 10.1038/nature17982

A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C

Makino, Asami, Abe, Mitsuhiro, Ishitsuka, Reiko, Murate, Motohide, Kishimoto, Takuma, Sakai, Shota, Hullin-Matsuda, Françoise, Shimada, Yukiko, Inaba, Takehiko, Miyatake, Hideyuki, Tanaka, Hideko, Kurahashi, Atsushi, Pack, Chan-Gi, Kasai, Rinshi S., Kubo, Shuku, Schieber, Nicole L., Dohmae, Naoshi, Tochio, Naoya, Hagiwara, Kyoji, Sasaki, Yutaka, Aida, Yoko, Fujimori, Fumihiro, Kigawa, Takanori, Nishibori, Kozo, Parton, Robert G., Kusumi, Akihiro, Sako, Yasushi, Anderluh, Gregor, Yamashita, Makoto ... Kobayashi, Toshihide (2016). A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C. FASEB Journal, 31 (4), 1301-1322. doi: 10.1096/fj.201500075R

Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling

Humphrey, Emily S., Su, Shih-Ping, Nagrial, Adnan M., Hochgraefe, Falko, Pajic, Marina, Lehrbach, Gillian M., Parton, Robert G., Yap, Alpha S., Horvath, Lisa G., Chang, David K., Biankin, Andrew V., Wu, Jianmin and Daly, Roger J. (2016). Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling. Molecular and Cellular Proteomics, 15 (8), 2671-2685. doi: 10.1074/mcp.M116.058313

AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation

Cullen, Jason K., Murad, Norazian Abdul, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L., Parton, Robert G., Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J., Stocker, Roland and Lavin, Martin F. (2016). AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation. Plos One, 11 (7) e0160162, e0160162. doi: 10.1371/journal.pone.0160162

Annexin A6 regulates interleukin-2-mediated T-cell proliferation

Cornely, Rhea, Pollock, Abigail H., Rentero, Carles, Norris, Sarah E., Alvarez-Guaita, Anna, Grewal, Thomas, Mitchell, Todd, Enrich, Carlos, Moss, Stephen E., Parton, Robert G., Rossy, Jeremie and Gaus, Katharina (2016). Annexin A6 regulates interleukin-2-mediated T-cell proliferation. Immunology and Cell Biology, 94 (6), 543-553. doi: 10.1038/icb.2016.15

New transgenic lines for localization of GFP-tagged proteins by electron microscope

Hall, Thomas, Ariotti, Nicholas, Ferguson, Charles, Zherui, Xiong and Parton, Robert G. (2016). New transgenic lines for localization of GFP-tagged proteins by electron microscope. Zebrafish, 13 (3), 232-233. doi: 10.1089/zeb.2016.29002.hal

Interplay between hepatic mitochondria-Associated membranes, lipid metabolism and caveolin-1 in mice

Sala-Vila, Aleix, Navarro-Lerida, Inmaculada, Sanchez-Alvarez, Miguel, Bosch, Marta, Calvo, Carlos, Lopez, Juan Antonio, Calvo, Enrique, Ferguson, Charles, Giacomello, Marta, Serafini, Annalisa, Scorrano, Luca, Enriquez, Jose Antonio, Balsinde, Jesus, Parton, Robert G., Vazquez, Jesus, Pol, Albert and Del Pozo, Miguel A. (2016). Interplay between hepatic mitochondria-Associated membranes, lipid metabolism and caveolin-1 in mice. Scientific Reports, 6 (1) 27351, 27351. doi: 10.1038/srep27351

Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr-/- mice

Pollock, Abigail H., Tedla, Nicodemus, Hancock, Sarah E., Cornely, Rhea, Mitchell, Todd W., Yang, Zhengmin, Kockx, Maaike, Parton, Robert G., Rossy, Jeremie and Gaus, Katharina (2016). Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr-/- mice. Journal of Immunology, 196 (10), 3993-4002. doi: 10.4049/jimmunol.1501261

Human immune cell targeting of protein nanoparticles-caveospheres

Glass, Joshua J., Yuen, Daniel, Rae, James, Johnston, Angus P. R., Parton, Robert G., Kent, Stephen J. and De Rose, Robert (2016). Human immune cell targeting of protein nanoparticles-caveospheres. Nanoscale, 8 (15), 8255-8265. doi: 10.1039/c6nr00506c

Cell polarity defines three distinct domains in pancreatic beta cells

Gan, Wan J., Zavortink, Michael, Ludick, Christine, Templin, Rachel, Webb, Robyn, Webb, Richard, Ma, Wei, Poronnik, Philip, Parton, Robert G., Gaisano, Herbert Y., Shewan, Annette M. and Thorn, Peter (2016). Cell polarity defines three distinct domains in pancreatic beta cells. Journal of Cell Science, 130 (1), 1-9. doi: 10.1242/jcs.185116

AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation

Cullen, Jason K., Murad, Norazian Abdul, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L., Parton, Robert G., Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J., Stocker, Roland and Lavin, Martin F. (2016). AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation. PLoS One, 11 (2) e0148213, e0148213. doi: 10.1371/journal.pone.0148213

Mechanoprotection by skeletal muscle caveolae

Lo, Harriet P., Hall, Thomas E. and Parton, Robert G. (2016). Mechanoprotection by skeletal muscle caveolae. BioArchitecture, 6 (1), 22-27. doi: 10.1080/19490992.2015.1131891

Coronin 1B reorganizes the architecture of f-actin networks for contractility at steady-state and apoptotic adherens junctions

Michael, Magdalene, Meiring, Joyce C. M., Acharya, Bipul R., Matthews, Daniel R., Verma, Suzie, Han, Siew Ping, Hill, Michelle M., Parton, Robert G., Gomez, Guillermo A. and Yap, Alpha S. (2016). Coronin 1B reorganizes the architecture of f-actin networks for contractility at steady-state and apoptotic adherens junctions. Developmental Cell, 37 (1), 58-71. doi: 10.1016/j.devcel.2016.03.008

Modular detection of GFP-labeled proteins for rapid screening by electron microscopy in cells and organisms

Ariotti, Nicholas, Hall, Thomas, Rae, James, Ferguson, Charles, McMahon, Kerrie-Ann, Martel, Nick, Webb, Robyn E., Webb, Richard I., Teasdale, Rohan D. and Parton, Robert G. (2015). Modular detection of GFP-labeled proteins for rapid screening by electron microscopy in cells and organisms. Developmental Cell, 35 (4), 513-525. doi: 10.1016/j.devcel.2015.10.016

High-density lipoprotein inhibits human M1 macrophage polarization through redistribution of caveolin-1

Lee, Man K.S., Moore, Xiao-Lei, Fu, Yi, Al-Sharea, Annas, Dragoljevic, Dragana, Fernandez-Rojo, Manuel A., Parton, Robert, Sviridov, Dmitri, Murphy, Andrew J. and Chin-Dusting, Jaye P.F. (2015). High-density lipoprotein inhibits human M1 macrophage polarization through redistribution of caveolin-1. British Journal of Pharmacology, 173 (4), 741-751. doi: 10.1111/bph.13319

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Takasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., de Sousa Lopes, Susana M. Chuva and Little, Melissa H. (2015). Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 526 (7574), 564-568. doi: 10.1038/nature15695

Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion

Parchure, Anup, Vyas, Neha, Ferguson, Charles, Parton, Robert G. and Mayor, Satyajit (2015). Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion. Molecular Biology of The Cell, 26 (25), 1-35. doi: 10.1091/mbc.E15-09-0671

A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation

Tillu, Vikas A., Kovtun, Oleksiy, McMahon, Kerrie-Ann, Collins, Brett M. and Parton, Robert G. (2015). A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation. Molecular Biology of the Cell, 26 (20), 3561-3569. doi: 10.1091/mbc.E15-06-0359

Adherens Junctions Revisualized: Organizing Cadherins as Nanoassemblies

Yap, Alpha S., Gomez, Guillermo A. and Parton, Robert G. (2015). Adherens Junctions Revisualized: Organizing Cadherins as Nanoassemblies. Developmental Cell, 35 (1) 3402, 12-20. doi: 10.1016/j.devcel.2015.09.012

Molecular characterization of caveolin-induced membrane curvature

Ariotti, Nicholas, Rae, James, Leneva, Natalya, Ferguson, Charles, Loo, Dorothy, Okano, Satomi, Hill, Michelle M., Walser, Piers, Collins, Brett M. and Parton, Robert G. (2015). Molecular characterization of caveolin-induced membrane curvature. Journal of Biological Chemistry, 290 (41), 24875-24890. doi: 10.1074/jbc.M115.644336

APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

Kalaidzidis, Inna, Miaczynska, Marta, Brewinska-Olchowik, Marta, Hupalowska, Anna, Ferguson, Charles, Parton, Robert G., Kalaidzidis, Yannis and Zerial, Marino (2015). APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments. Journal of Cell Biology, 211 (1), 123-144. doi: 10.1083/jcb.201311117

The caveolin–cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle

Lo, Harriet P., Nixon, Susan Jane, Hall, Thomas Edward, Cowling, Belinda Simone, Ferguson, Charles, Morgan, Garry Patrick, Schieber, Nicole Louise, Fernandez-Rojo, Manuel Alejandro, Bastiani, Michele, Floetenmeyer, Matthias, Martel, Nick, Laporte, Jocelyn, Pilch, Paul F. and Parton, Robert (2015). The caveolin–cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle. The Journal of Experimental Medicine, 212 (10), 833-849. doi: 10.1084/jem.21210oia80

Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis

Zeyad Nassar, Hill, Michelle, Parton, Robert G., Francois, Mathias and Parat, Marie-Odile (2015). Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis. Oncoscience, 2 (7), 635-645. doi: 10.18632/oncoscience.180

The caveolin-cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle

Lo, Harriet P., Nixon, Susan J., Hall, Thomas E., Cowling, Belinda S., Ferguson, Charles, Morgan, Garry P., Schieber, Nicole L., Fernandez-Rojo, Manuel A., Bastiani, Michele, Floetenmeyer, Matthias, Martel, Nick, Laporte, Jocelyn, Pilch, Paul F. and Parton, Robert G. (2015). The caveolin-cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle. Journal of Cell Biology, 210 (5), 833-849. doi: 10.1083/jcb.201501046

Seeing and believing: recent advances in imaging cell-cell interactions

Yap, Alpha S., Michael, Magdalene and Parton, Robert G. (2015). Seeing and believing: recent advances in imaging cell-cell interactions. F1000Research, 4 (F1000 Faculty Rev) 273, 273.1-273.8. doi: 10.12688/f1000research.6435.1

MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line

Faggi, Fiorella, Codenotti, Silvia, Poliani, Pietro Luigi, Cominelli, Manuela, Chiarelli, Nicola, Colombi, Marina, Vezzoli, Marika, Monti, Eugenio, Bono, Federica, Tulipano, Giovanni, Fiorentini, Chiara, Zanola, Alessandra, Lo, Harriet P., Parton, Robert G., Keller, Charles and Fanzani, Alessandro (2015). MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line. PLoS One, 10 (6) e0130287, e0130287-e0130287. doi: 10.1371/journal.pone.0130287

Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy

Shi, Yin, Tan, Shi-Hao, Ng, Shukie, Zhou, Jing, Yang, Na-Di, Khoo, Gi-Bang, McMahon, Kerrie-Ann, Parton, Robert G., Hill, Michelle, del Pozo, Miguel A., Kim, You-Sun and Shen, Han-Ming (2015). Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy. Autophagy, 11 (5), 769-784. doi: 10.1080/15548627.2015.1034411

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

Herms, Albert, Bosch, Marta, Reddy, Babu J. N., Schieber, Nicole L., Fajardo, Alba, Ruperez, Celia, Fernandez-Vidal, Andrea, Ferguson, Charles, Rentero, Carles, Tebar, Francesc, Enrich, Carlos, Parton, Robert G., Gross, Steven P. and Pol, Albert (2015). AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation. Nature Communications, 6 (1) 7176, 7176.1-7176.14. doi: 10.1038/ncomms8176

Building endocytic pits without clathrin

Ludgar, Johannes, Parton, Robert G., Bassereau, Patricia and Mayor, Satyajit (2015). Building endocytic pits without clathrin. Nature Reviews Molecular Cell Biology, 16 (5), 311-321. doi: 10.1038/nrm3968

An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions

Gomez, Guillermo A., McLachlan, Robert W., Wu, Selwin K., Caldwell, Benjamin J., Moussa, Elliott, Verma, Suzie, Bastiani, Michele, Priya, Rashmi, Parton, Robert G., Gaus, Katharina, Sap, Jan and Yap, Alpha S. (2015). An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions. Molecular Biology of the Cell, 26 (7), 1249-1262. doi: 10.1091/mbc.E14-07-1223

Cavin family proteins and the assembly of caveolae

Kovtun, Oleksiy, Tillu, Vikas A., Ariotti, Nicholas, Parton, Robert G. and Collins, Brett M. (2015). Cavin family proteins and the assembly of caveolae. Journal of Cell Science, 128 (7), 1269-1278. doi: 10.1242/jcs.167866

The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells

Phuyal, Santosh, Skotland, Tore, Hessvik, Nina Pettersen, Simolin, Helena, Overbye, Anders, Brech, Andreas, Parton, Robert G., Ekroos, Kim, Sandvig, Kirsten and Llorente, Alicia (2015). The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells. Journal of Biological Chemistry, 290 (7), 4225-4237. doi: 10.1074/jbc.M114.593962

Discreet and distinct clustering of five model membrane proteins revealed by single molecule localization microscopy

Magenau, Astrid, Owen, Dylan M., Yamamoto, Yui, Tran, Jason, Kwiatek, Joanna M., Parton, Robert G. and Gaus, Katharina (2015). Discreet and distinct clustering of five model membrane proteins revealed by single molecule localization microscopy. Molecular Membrane Biology, 32 (1), 1-8. doi: 10.3109/09687688.2014.990997

Are caveolae a cellular entry route for non-viral therapeutic delivery systems?

Rewatkar, Prarthana V., Parton, Robert G., Parekh, Harendra S. and Parat, Marie-Odile (2015). Are caveolae a cellular entry route for non-viral therapeutic delivery systems?. Advanced Drug Delivery Reviews, 91, 92-108. doi: 10.1016/j.addr.2015.01.003

Diet-induced hypercholesterolemia promotes androgenindependent prostate cancer metastasis via IQGAP1 and caveolin-1

Moon, Hyeongsun, Ruelcke, Jayde E., Choi, Eunju, Sharpe, Laura J., Nassar, Zeyad D., Bielefeldt-ohmann, Helle, Parat, Marie-Odile, Shah, Anup, Francois, Mathias, Inder, Kerry L., Brown, Andrew J., Russell, Pamela J., Parton, Robert G. and Hill, Michelle M. (2015). Diet-induced hypercholesterolemia promotes androgenindependent prostate cancer metastasis via IQGAP1 and caveolin-1. Oncotarget, 6 (10), 7438-7453. doi: 10.18632/oncotarget.3476

Caveolae control the anti-inflammatory phenotype of senescent endothelial cells

Powter, Elizabeth E., Coleman, Paul R., Tran, Mai H., Lay, Angelina J., Bertolino, Patrick, Parton, Robert G., Vadas, Mathew A. and Gamble, Jennifer R. (2014). Caveolae control the anti-inflammatory phenotype of senescent endothelial cells. Aging Cell, 14 (1), 102-111. doi: 10.1111/acel.12270

Visualization of the heterogeneous membrane distribution of sphingomyelin associated with cytokinesis, cell polarity, and sphingolipidosis

Makino, Asami, Abe, Mitsuhiro, Murate, Motohide, Inaba, Takehiko, Yilmaz, Neval, Hullin-Matsuda, Francoise, Kishimoto, † Takuma, Schieber, Nicole L., Taguchi, Tomohiko, Arai, Hiroyuki, Anderluh, Gregor, Parton, Robert G. and Kobayashi, Toshihide (2014). Visualization of the heterogeneous membrane distribution of sphingomyelin associated with cytokinesis, cell polarity, and sphingolipidosis. The FASEB Journal, 29 (2), 477-493. doi: 10.1096/fj.13-247585

Structural insights into the organization of the cavin membrane coat complex

Kovtun, Oleksiy, Tilu, Vikas A., Jung, WooRam, Leneva, Natalya, Ariotti, Nicholas, Chaudhary, Natasha, Mandyam, Ramya A., Ferguson, Charles, Morgan, Garry P., Johnston, Wayne A., Harrop, Stephen J., Alexandrov, Kirill, Parton, Robert G. and Collins, Brett M. (2014). Structural insights into the organization of the cavin membrane coat complex. Developmental Cell, 31 (4), 405-419. doi: 10.1016/j.devcel.2014.10.002

Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways

Gupta, Gagan D., Dey, Gautam, MG, Swetha, Ramalingam, Balaji, Shameer, Khader, Thottacherry, Joseph Jose, Kalappurakkal, Joseph Mathew, Howes, Mark T., Chandran, Ruma, Das, Anupam, Menon, Sindhu, Parton, Robert G., Sowdhamini, R., Thattai, Mukund and Mayor, Satyajit (2014). Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways. PLoS ONE, 9 (6) e100554, e100554.1-e100554.19. doi: 10.1371/journal.pone.0100554

Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation

Inder, Kerry L., Ruelcke, Jayde E., Petelin, Lara, Moon, Hyeongsun, Choi, Eunju, Rae, James, Blumenthal, Antje, Hutmacher, Dietmar, Saunders, Nicholas A., Stow, Jennifer L., Parton, Robert G. and Hill, Michelle M. (2014). Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation. Journal of Extracellular Vesicles, 3 (1) 23784, 23784.1-23784.14. doi: 10.3402/jev.v3.23784

Clathrin-independent pathways of endocytosis

Mayor, Satyajit, Parton, Robert G. and Donaldson, Julie G. (2014). Clathrin-independent pathways of endocytosis. Cold Spring Harbor Perspectives in Biology, 6 (6), 1-20. doi: 10.1101/cshperspect.a016758

Pkd1 regulates lymphatic vascular morphogenesis during development

Coxam, Baptiste, Sabine, Amelie, Bower, Neil I., Smith, Kelly A., Pichol-Thievend, Cathy, Skoczylas, Renae, Astin, Jonathan W., Frampton, Emmanuelle, Jaquet, Muriel, Crosier, Philip S., Parton, Robert G., Harvey, Natasha L., Petrova, Tatiana V., Schulte-Merker, Stefan, Francois, Mathias and Hogan, Benjamin M. (2014). Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Reports, 7 (3), 623-633. doi: 10.1016/j.celrep.2014.03.063

Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis

Chaudhary, Natasha, Gomez, Guillermo A., Howes, Mark T., Lo, Harriet P., McMahon, Kerrie-Ann, Rae, James A., Schieber, Nicole L., Hill, Michelle M., Gaus, Katharina, Yap, Alpha S. and Parton, Robert G. (2014). Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis. PLoS Biology, 12 (4) e1001832, e1001832.1-e1001832.20. doi: 10.1371/journal.pbio.1001832

Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites

Pol, Albert, Gross, Steven P. and Parton, Robert G. (2014). Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites. Journal of Cell Biology, 204 (5), 635-646. doi: 10.1083/jcb.201311051

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling

Ariotti, Nicholas, Fernández-Rojo, Manuel, Zhou, Yong, Hill, Michelle M., Rodkey, Travis L., Inder, Kerry L., Tanner, Lukas B., Wenk, Markus R., Hancock, John F. and Parton, Robert G. (2014). Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling. Journal of Cell Biology, 204 (5), 777-792. doi: 10.1083/jcb.201307055

Cortical F-actin stabilization generates apical–lateral patterns of junctional contractility that integrate cells into epithelia

Wu, Selwin K., Gomez, Guillermo A., Michael, Magdalene, Verma, Suzie, Cox, Hayley L., Lefevre, James G., Parton, Robert G., Hamilton, Nicholas A., Neufeld, Zoltan and Yap, Alpha S. (2014). Cortical F-actin stabilization generates apical–lateral patterns of junctional contractility that integrate cells into epithelia. Nature Cell Biology, 16 (2), 167-178. doi: 10.1038/ncb2900

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

Gambin, Yann, Ariotti, Nicholas, McMahon, Kerrie-Ann, Bastiani, Michele, Sierecki, Emma, Kovtun, Oleksiy, Polinkovsky, Mark E., Magenau, Astrid, Jung, WooRam, Okano, Satomi, Zhou, Yong, Leneva, Natalya, Mureev, Sergey, Johnston, Wayne, Gaus, Katharina, Hancock, John F., Collins, Brett M., Alexandrov, Kirill and Parton, Robert G. (2014). Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. eLIFE, 2014 (3) e01434, e01434.1-e01434.18. doi: 10.7554/eLife.01434

Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens

Han, Siew Ping, Gambin, Yann, Gomez, Guillermo A., Verma, Suzie, Giles, Nichole, Michael, Magdalene, Wu, Selwin K., Guo, Zhong, Johnston, Wayne, Sierecki, Emma, Parton, Robert G., Alexandrov, Kirill and Yap, Alpha S. (2014). Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens. Journal of Biological Chemistry, 289 (11) 790, 7764-7775. doi: 10.1074/jbc.M113.544478

Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers

Lakshminarayan, Ramya, Wunder, Christian, Becken, Ulrike, Howes, Mark T., Benzing, Carola, Arumugam, Senthil, Sales, Susanne, Ariotti, Nicholas, Chambon, Valérie, Lamaze, Christophe, Loew, Damarys, Shevchenko, Andrej, Gaus, Katharina, Parton, Robert G. and Johannes, Ludger (2014). Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers. Nature Cell Biology, 16 (6), 592-603. doi: 10.1038/ncb2970

PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer

Moon, H., Lee, C. S., Inder, K. L., Sharma, S., Choi, E., Black, D. M., Lê Cao, K.-A., Winterford, C., Coward, J. I., Ling, M. T., Craik, D. J., Parton, R. G., Russell, P.J., Hill, M. M. and The Australian Prostate Cancer BioResource (2014). PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer. Oncogene, 33 (27), 3561-3570. doi: 10.1038/onc.2013.315

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

Kassan, Adam, Herms, Albert, Fernandez-Vidal, Andrea, Bosch, Marta, Schieber, Nicole L., Reddy, Babu J. N., Fajardo, Alba, Gelabert-Baldrich, Mariona, Tebar, Francesc, Enrich, Carlos, Gross, Steven P., Parton, Robert G. and Pol, Albert (2013). Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains. Journal of Cell Biology, 203 (6), 985-1001. doi: 10.1083/jcb.201305142

Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters

Zhou, Yong, Liang, Hong, Rodkey, Travis, Ariotti, Nicholas, Parton, Robert G. and Hancock, John F. (2013). Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters. Molecular and Cellular Biology, 34 (5), 862-876. doi: 10.1128/MCB.01227-13

Building a better dynasore: the Dyngo compounds potently inhibit dynamin and endocytosis

McCluskey, Adam, Daniel, James A., Hadzic, Gordana, Chau, Ngoc, Clayton, Emma L., Mariana, Anna, Whiting, Ainslie, Gorgani, Nick N., Lloyd, Jonathan, Quan, Annie, Moshkanbaryans, Lia, Krishnan, Sai, Perera, Swetha, Chircop, Megan, von Kleist, Lisa, McGeachie, Andrew B., Howes, Mark T., Parton, Robert G., Campbell, Michael, Sakoff, Jennette A., Wang, Xuefeng, Sun, Jian-Yuan, Robertson, Mark J., Deane, Fiona M., Nguyen, Tam H., Meunier, Frederic A., Cousin, Michael A. and Robinson, Phillip J. (2013). Building a better dynasore: the Dyngo compounds potently inhibit dynamin and endocytosis. Traffic, 14 (12), 1272-1289. doi: 10.1111/tra.12119

Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell

Low, Jiun T., Mitchell, Justin M., Do, Oanh H., Bax, Jacinda, Rawlings, Alicia, Zavortink, Michael, Garry Morgan, Parton, Robert G., Gaisano, Herbert Y. and Thorn, Peter (2013). Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell. Diabetologia, 56 (12), 2629-2637. doi: 10.1007/s00125-013-3019-5

PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis

Nassar, Zeyad D., Moon, Hyeongsun, Duong, Tam, Neo, LiQi, Hill, Michelle M., Francois, Mathias, Parton, Robert G. and Parat, Marie-Odile (2013). PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis. Oncotarget, 4 (10), 1844-1855. doi: 10.18632/oncotarget.1300

Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission

Palmer C.S., Elgass K.D., Parton R.G., Osellame L.D., Stojanovski D. and Ryan M.T. (2013). Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. Journal of Biological Chemistry, 288 (38), 27584-27593. doi: 10.1074/jbc.M113.479873

Caveola-forming proteins caveolin‑1 and PTRF in prostate cancer

Nassar, Zeyad D., Hill, Michelle M., Parton, Robert G. and Parat, Marie-Odile (2013). Caveola-forming proteins caveolin‑1 and PTRF in prostate cancer. Nature Reviews Urology, 10 (9), 529-536. doi: 10.1038/nrurol.2013.168

Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity

Herms, Albert, Bosch, Marta, Ariotti, Nicholas, Reddy, Babu J. N., Fajardo, Alba, Fernandez-Vidal, Andrea, Alvarez-Guaita, Anna, Fernandez-Rojo, Manuel Alejandro, Rentero, Carles, Tebar, Francesc, Enrich, Carlos, Geli, Maria-Isabel, Parton, Robert G., Gross, Steven P. and Pol, Albert (2013). Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity. Current Biology, 23 (15), 1489-1496. doi: 10.1016/j.cub.2013.06.032

Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets

Salloum, Shadi, Wang, Hongliang, Ferguson, Charles, Parton, Robert G. and Tai, Andrew W. (2013). Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets. PLoS Pathogens, 9 (8) e1003513, e1003513. doi: 10.1371/journal.ppat.1003513

SnapShot: caveolae, caveolins, and cavins

Ariotti, Nicholas and Parton Robert G. (2013). SnapShot: caveolae, caveolins, and cavins. Cell, 154 (3), 704-705. doi: 10.1016/j.cell.2013.07.009

Patched1 is required in neural crest cells for the prevention of orofacial clefts

Metzis, Vicki, Courtney, Andrew D., Kerr, Markus C., Ferguson, Charles, Rondón Galeano, Maria C., Parton, Robert G., Wainwright, Brandon J. and Wicking, Carol (2013). Patched1 is required in neural crest cells for the prevention of orofacial clefts. Human Molecular Genetics, Advance Access (24) ddt353, 1-10. doi: 10.1093/hmg/ddt353

Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling

Fernández Rojo, Manuel, Gongora, Milena, Fitzsimmons, Rebecca L., Martel, Nick, Martin, Sheree D., Nixon, Susan, Brooks, Andrew J., Ikonomopoulou, Maria P., Martin, Sally, Lo, Harriet P., Myers, Stephen A., Restall, Christina, Ferguson, Charles, Pilch, Paul F., McGee, Sean L., Anderson, Robin L., Waters, Michael J., Hancock, John F., Grimmond, Sean M., Muscat, George E. and Parton, Robert G. (2013). Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling. Cell Reports, 4 (2), 238-247. doi: 10.1016/j.celrep.2013.06.017

Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers

Jayasinghe, Isuru D., Lo, Harriet P., Morgan, Garry P., Baddeley, David, Parton, Robert G., Soeller, Christian and Launikonis, Bradley S. (2013). Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers. Biophysical Journal, 104 (11), L19-L21. doi: 10.1016/j.bpj.2013.04.029

PNPLA3/adiponutrin functions in lipid droplet formation

Chamoun, Zeina, Vacca, Fabrizio, Parton, Robert G. and Gruenberg, Jean (2013). PNPLA3/adiponutrin functions in lipid droplet formation. Biology of the Cell, 105 (5), 219-233. doi: 10.1111/boc.201200036

RhoD participates in the regulation of cell-cycle progression and centrosome duplication

Kyrkou, A., Soufi, M., Bahtz, R., Ferguson, C., Bai, M., Parton, R. G., Hoffmann, I., Zerial, M., Fotsis, T. and Murphy, C. (2013). RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene, 32 (14), 1831-1842. doi: 10.1038/onc.2012.195

Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation (vol 199, pg 425, 2012)

Joshi, Bharat, Bastiani, Michele, Strugnell, Scott S., Boscher, Cecile, Parton, Robert G. and Nabi, Ivan R. (2013). Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation (vol 199, pg 425, 2012). Journal of Cell Biology, 200 (5), 681-681. doi: 10.1083/jcb.2012070892005c

Characterisation of the adiponectin receptors: the non-conserved N-terminal region of AdipoR2 prevents its expression at the cell-surface

Keshvari, Sahar, Rose, Felicity J., Charlton, Hayley K., Scheiber, Nicole L., Webster, Julie, Kim, Yu-Hee, Choaping Ng, Parton, Robert G. and Whitehead, Jonathan P. (2013). Characterisation of the adiponectin receptors: the non-conserved N-terminal region of AdipoR2 prevents its expression at the cell-surface. Biochemical and Biophysical Research Communications, 432 (1), 28-33. doi: 10.1016/j.bbrc.2013.01.092

Caveolae as plasma membrane sensors, protectors and organizers

Parton, Robert G. and del Pozo, Miguel A. (2013). Caveolae as plasma membrane sensors, protectors and organizers. Nature Reviews Molecular Cell Biology, 14 (2), 98-112. doi: 10.1038/nrm3512

The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments

Cortese, Katia, Howes, Mark T., Lundmark, Richard, Tagliatti, Erica, Bagnato, Paola, Petrelli, Annalisa, Bono, Maria, McMahon, Harvey T., Parton, Robert G. and Tacchetti, Carlo (2013). The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments. Molecular Biology of the Cell, 24 (2), 129-144. doi: 10.1091/mbc.E12-04-0282

Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission

van der Hoeven, Dharini, Cho, Kwang-jin, Ma, Xiaoping, Chigurupati, Sravanthi, Parton, Robert G. and Hancock, John F. (2013). Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Molecular and Cellular Biology, 33 (2), 237-251. doi: 10.1128/MCB.00884-12

The RhoD to centrosomal duplication

Kyrkou, Athena, Soufi, Maria, Blatz, Ramona, Ferguson, Charles, Bai, Maria, Parton, Robert G., Hoffman, Ingrid, Zerial, Marino, Fotsis, Theodore and Murphy, Carol (2013). The RhoD to centrosomal duplication. Small GTPases, 4 (2), 116-122. doi: 10.4161/sgtp.23707

Staurosporines disrupt phosphatidylserine trafficking and mislocalize ras proteins

Cho, Kwang-jin, Park, Jin-Hee, Piggott, Andrew M., Salim, Angela A., Gorfe, Alemaheyu A., Parton, Robert G., Capon, Robert J., Lacey, Ernest and Hancock, John F. (2012). Staurosporines disrupt phosphatidylserine trafficking and mislocalize ras proteins. Journal of Biological Chemistry, 287 (52), 43573-43584. doi: 10.1074/jbc.M112.424457

Different characteristics and nucleotide binding properties of Inosine Monophosphate Dehydrogenase (IMPDH) isoforms

Thomas, Elaine C., Gunter, Jennifer H., Webster, Julie A., Schieber, Nicole L., Oorschot, Viola, Parton, Robert G. and Whitehead, Jonathan P. (2012). Different characteristics and nucleotide binding properties of Inosine Monophosphate Dehydrogenase (IMPDH) isoforms. PloS One, 7 (12) e51096, e51096.1-e51096.14. doi: 10.1371/journal.pone.0051096

Normalization of protein at different stages in SILAC subcellular proteomics affects functional analysis

Inder, Kerry L., Loo, Dorothy, Zheng, Yu Zi, Parton, Robert G., Foster, Leonard J. and Hill, Michelle M. (2012). Normalization of protein at different stages in SILAC subcellular proteomics affects functional analysis. Journal of Integrated OMICS, 2 (2), 114-122. doi: 10.5584/jiomics.v2i2.108

Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation

Bharat, Joshi, Bastiani, Michele, Strugnell, Scott S., Boscher, Cecile, Parton, Robert G. and Nabi, Ivan R. (2012). Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation. Journal of Cell Biology, 199 (3), 425-435. doi: 10.1083/jcb.201207089

Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model

Martin, Sally, Fernandez Rojo, Manuel A., Stanley, Amanda C., Bastiani, Michele, Okano, Satomi, Nixon, Susan J., Thomas, Gethin, Stow, Jennifer L. and Parton, Robert G. (2012). Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model. PLoS One, 7 (9) e46242, e46242. doi: 10.1371/journal.pone.0046242

Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages

Fu, Yi, Moore, Xiao-Lei, Lee, Man K. S., Fernández-Rojo, Manuel A., Parat, Marie-Odile, Parton, Robert G., Meikle, Peter J., Sviridov, Dmitri and Chin-Dusting, Jaye P. F. (2012). Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology, 32 (9), e117-e125. doi: 10.1161/ATVBAHA.112.254151

Constitutive formation of caveolae in a bacterium

Walser, Piers, Ariotti, Nicholas, Howes, Mark, Ferguson, Charles, Webb, Richard, Schwudke, Dominik, Leneva, Natalya, Cho, Kwang-Jin, Cooper, Leanne, Rae, James, Floetenmeyer, Matthias, Oorschot, Viola M. J., Skoglund, Ulf, Simons, Kai, Hancock, John F. and Parton, Robert G. (2012). Constitutive formation of caveolae in a bacterium. Cell, 150 (4), 752-763. doi: 10.1016/j.cell.2012.06.042

Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1

Hill, Michelle M., Daud, Noor Huda, Aung, Cho Sanda, Loo, Dorothy, Martin, Sally, Murphy, Samantha, Black, Debra M., Barry, Rachael, Simpson, Fiona, Liu, Libin, Pilch, Paul F, Hancock, John F., Marie-Odile Parat and Parton, Robert G. (2012). Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1. PLoS One, 7 (8) e43041, e43041.1-e43041.9. doi: 10.1371/journal.pone.0043041

Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors

Kohnke, Monika, Schmitt, Steven, Ariotti, Nicholas, Piggott, Andrew, Parton, Robert G., Lacey, Ernest, Capon, Robert, Alexandrov, Kirill and Abankwa, Daniel (2012). Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors. Chemistry and Biology, 19 (7), 866-874. doi: 10.1016/j.chembiol.2012.05.019

Structure-based reassessment of the caveolin signalling model: Do caveolae regulate signaling through caveolin-protein interactions

Collins, Brett, Davis, Melissa, Hancock, John F. and Parton, Robert G. (2012). Structure-based reassessment of the caveolin signalling model: Do caveolae regulate signaling through caveolin-protein interactions. Developmental Cell, 23 (1), 11-20. doi: 10.1016/j.devcel.2012.06.012

SNX12 role in endosome membrane transport

Pons, Veronique, Ustunel, Cansel, Rolland, Corinne, Torti, Eleonora, Parton, Robert G. and Gruenberg, Jean (2012). SNX12 role in endosome membrane transport. PLoS One, 7 (6) e38949, e38949.1-e38949.8. doi: 10.1371/journal.pone.0038949

Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration

Fernandez Rojo, Manuel Alejandro, Restall, Christina, Ferguson, Charles, Martel, Nick, Martin, Sally, Bosch, Marta, Kassan, Adam, Leong, Gary M., Martin, Sheree D., McGee, Sean L., Muscat, George E., Anderson, Robin L., Enrich, Carlos, Pol, Albert and Parton, Robert G. (2012). Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration. Hepatology, 55 (5), 1574-1584. doi: 10.1002/hep.24810

EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization

Moren, Björn, Shah, Claudio, Howes, Mark T., Schieber, Nicole L., McMahon, Harvey T., Parton, Robert G., Daumke, Oliver and Lundmark, Richard (2012). EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization. Molecular Biology of the Cell, 23 (7), 1316-1329. doi: 10.1091/mbc.E11-09-0787

Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies

Ashe, Alyson, Butterfield, Natalie C., Town, Liam, Courtney, Andrew D., Cooper, Ashley N., Ferguson, Charles, Barry, Rachael, Olsson, Fredrik, Liem, Karel F., Parton, Robert G., Wainwright, Brandon J., Anderson, Kathryn V., Whitelaw, Emma and Wicking, Carol (2012). Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Human Molecular Genetics, 21 (8) ddr613, 1808-1823. doi: 10.1093/hmg/ddr613

Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes

Ariotti, Nicholas, Samantha Murphy, Hamilton, Nicholas A., Wu, Lizhen, Green, Kathryn, Nicole Schieber, Li, Peng, Martin, Sally and Parton, Robert G. (2012). Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes. Molecular Biology of The Cell, 23 (10), 1826-1837. doi: 10.1091/mbc.E11-10-0847

Expression of PTRF in PC-3 cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways

Inder, Kerry L., Zheng, Yu Zi, Davis, Melissa J., Moon, Hyeongsun, Loo, Dorothy, Nguyen, Hien, Clements, Judith A., Parton, Robert G., Foster, Leonard J. and Hill, Michelle M. (2012). Expression of PTRF in PC-3 cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways. Molecular and Cellular Proteomics, 11 (2) M111.012245, M111.012245. doi: 10.1074/mcp.M111.012245

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

Gong, Jingyi, Sun, Zhiqi, Wu, Lizhen, Xu, Wenyi, Schieber, Nicole, Xu, Dijin, Shui, Guanghou, Yang, Hongyuan, Parton, Robert G. and Li, Peng (2011). Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. Journal of Cell Biology, 195 (6), 953-963. doi: 10.1083/jcb.201104142

The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading

Doherty, Gary J., Ahlund, Monika K., Howes, Mark T., Moren, Bjorn, Parton, Robert G., McMahon, Harvey T. and Lundmark, Richard (2011). The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading. Molecular Biology of the Cell, 22 (22), 4380-4389. doi: 10.1091/mbc.E10-12-0936

Quantitative proteomic analysis of the adipocyte plasma membrane

Prior, Matthew J., Larance, Mark, Lawrence, Robert T., Soul, Jamie, Humphrey, Sean, Burchfield, James, Kistler, Carol, Davey, Jonathon R., La-Borde, Penelope J., Buckley, Michael, Kanazawa, Hiroshi, Parton, Robert G., Guihaus, Michael and James, David E. (2011). Quantitative proteomic analysis of the adipocyte plasma membrane. Journal of Proteome Research, 10 (11), 4970-4982. doi: 10.1021/pr200446r

High-throughput screening of Australian marine organism extracts for bioactive molecules affecting the cellular storage of neutral lipids

Rae, James, Fontaine, Frank, Salim, Angela A., Lo, Harriet P., Capon, Robert J., Parton, Robert G. and Martin, Sally (2011). High-throughput screening of Australian marine organism extracts for bioactive molecules affecting the cellular storage of neutral lipids. PLoS One, 6 (8) e22868, e22868.1-e22868.13. doi: 10.1371/journal.pone.0022868

Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity

Meshulam, Tova, Breen, Michael R., Liu, Libin, Parton, Robert G. and Pilch, Paul F. (2011). Caveolins/caveolae protect adipocytes from fatty acid-mediated lipotoxicity. Journal of Lipid Research, 52 (8), 1526-1532. doi: 10.1194/jlr.M015628

Clearing the confusion of Cav1 and caveolae in cancer compartments

Hill, Michelle M., Parat, Marie-Odile, Parton, Robert G. and Lee, C. Soon (2011). Clearing the confusion of Cav1 and caveolae in cancer compartments. Cell Online, 146 (1).

A role for phosphatidic acid in the formation of "supersized" lipid droplets

Fei, Weihua, Shui, Guanghou, Zhang, Yuxi, Krahmer, Natalie, Ferguson, Charles, Kapterian, Tamar S., Lin, Ruby C., Dawes, Ian W., Brown, Andrew J., Li, Peng, Huang, Xun, Parton, Robert G., Wenk, Markus R., Walther, Tobias C. and Yang, Hongyuan (2011). A role for phosphatidic acid in the formation of "supersized" lipid droplets. Plos Genetics, 7 (7) e1002201, e1002201.1-e1002201.11. doi: 10.1371/journal.pgen.1002201

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

Fairn, Gregory D., Schieber, Nicole L., Ariotti, Nicholas, Murphy, Samantha, Kuerschner, Lars, Webb, Richard I., Grinstein, Sergio and Parton, Robert G. (2011). High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine. Journal of Cell Biology, 194 (2), 257-275. doi: 10.1083/jcb.201012028

Pore-forming toxins induce multiple cellular responses promoting survival

Gonzalez, Manuel R., Bischofberger, Mirko, Freche, Barbara, Ho, Sylvia, Parton, Robert G. and van der Goot, F. Gisou (2011). Pore-forming toxins induce multiple cellular responses promoting survival. Cellular Microbiology, 13 (7), 1026-1043. doi: 10.1111/j.1462-5822.2011.01600.x

Role of snx16 in the dynamics of tubulo-cisternal membrane domains of late endosomes

Brankatschk, Ben, Pons, Véronique, Parton, Robert G. and Gruenberg, Jean (2011). Role of snx16 in the dynamics of tubulo-cisternal membrane domains of late endosomes. PLoS One, 6 (7) e21771, e21771.1-e21771.15. doi: 10.1371/journal.pone.0021771

Redistribution of caveolae during mitosis

Boucrot, Emmanuel, Howes, Mark T., Kirchhausen, Tomas and Parton, Robert G. (2011). Redistribution of caveolae during mitosis. Journal of Cell Science, 124 (12), 1965-1972. doi: 10.1242/jcs.076570

Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes

Laulagnier, Karine, Schieber, Nicole L., Maritzen, Tanja, Haucke, Volker, Parton, Robert G. and Gruenberg, Jean (2011). Role of AP1 and Gadkin in the traffic of secretory endo-lysosomes. Molecular Biology of the Cell, 22 (12), 2068-2082. doi: 10.1091/mbc.E11-03-0193

Not just fat: The structure and function of the lipid droplet

Fujimoto, Toyoshi and Parton, Robert G. (2011). Not just fat: The structure and function of the lipid droplet. Cold Spring Harbor Perspectives in Biology, 3 (3), 004838.1-004838.17. doi: 10.1101/cshperspect.a004838

Therapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate Ras signaling via phospholipase D2

Cho, Kwang-jin, Hill, Michelle M., Chigurupati, Sravanthi, Du, Guangwei, Parton, Robert G. and Hancock, John F. (2011). Therapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate Ras signaling via phospholipase D2. Molecular and Cellular Biology, 31 (6), 1110-1120. doi: 10.1128/MCB.00989-10

Cells respond to mechanical stress by rapid disassembly of caveolae

Sinha, Bidisha, Koster, Darius, Ruez, Richard, Gonnord, Pauline, Bastiani, Michele, Abankwa, Daniel, Stan, Radu V., Butler-Browne, Gillian, Vedie, Benoit, Johannes, Ludger, Morone, Nobuhiro, Parton, Robert G., Raposo, Graca, Sens, Pierre, Lamaze, Christophe and Nassoy, Pierre (2011). Cells respond to mechanical stress by rapid disassembly of caveolae. Cell, 144 (3), 402-413. doi: 10.1016/j.cell.2010.12.031

PTRF-cavin -1 expression decreases the migration of PC3 prostate cancer cells: Role of matrix metalloprotease 9

Cho, Sanda Aung, Hill, Michelle M., Bastiani, Michele, Parton, Robert G. and Parat, Marie-Odile (2011). PTRF-cavin -1 expression decreases the migration of PC3 prostate cancer cells: Role of matrix metalloprotease 9. European Journal of Cell Biology, 90 (2-3), 136-142. doi: 10.1016/j.ejcb.2010.06.004

A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking

Du, Ximing, Kumar, Jaspal, Ferguson, Charles, Schulz, Timothy A., Ong, Yan Ong, Hong, Wanjin, Prinz, William A., Parton, Robert G., Brown, Andrew J. and Yang, Hongyuan (2011). A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. Journal of Cell Biology, 192 (1), 121-135. doi: 10.1083/jcb.201004142

Quantitative analysis of lipid droplet fusion: Inefficient steady state fusion but rapid stimulation by chemical fusogens

Murphy, S, Martin, S and Parton, RG (2010). Quantitative analysis of lipid droplet fusion: Inefficient steady state fusion but rapid stimulation by chemical fusogens. PLoS ONE, 5 (12) e15030, 1-12. doi: 10.1371/journal.pone.0015030

Caveolae at a glance

Bastiani, M and Parton, RG (2010). Caveolae at a glance. Journal of Cell Science, 123 (22), 3831-3836. doi: 10.1242/jcs.070102

Revisiting caveolin trafficking: the end of the caveosome

Parton, Robert G. and Howes, Mark T. (2010). Revisiting caveolin trafficking: the end of the caveosome. Journal of Cell Biology, 191 (3), 439-441. doi: 10.1083/jcb.201009093

Sequence-Dependent Sorting of Recycling Proteins by Actin-Stabilized Endosomal Microdomains

Puthenveedu, MA, Lauffer, B, Temkin, P, Vistein, R, Carlton, P, Thorn, K, Taunton, J, Weiner, OD, Parton, RG and von Zastrow, M (2010). Sequence-Dependent Sorting of Recycling Proteins by Actin-Stabilized Endosomal Microdomains. Cell, 143 (5), 761-773. doi: 10.1016/j.cell.2010.10.003

Reduced plasma membrane expression of dysferlin mutants is attributed to accelerated endocytosis via a syntaxin-4-associated pathway

Evesson, Frances J., Peat, Rachel A., Lek, Angela, Brilot, Fabienne, Lo, Harriet P., Dale, Russell C., Parton, Robert G., North, Kathryn N. and Cooper, Sandra T. (2010). Reduced plasma membrane expression of dysferlin mutants is attributed to accelerated endocytosis via a syntaxin-4-associated pathway. Journal of Biological Chemistry, 285 (37), 28529-28539. doi: 10.1074/jbc.M110.111120

Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

Howes, Mark T., Kirkham, Matthew, Riches, James, Cortese, Katia, Walser, Piers J., Simpson, Fiona, Hill, Michelle M., Jones, Alun, Lundmark, Richard, Lindsay, Margaret R., Hernandez-Deviez, Delia J., Hadzic, Gordana, McCluskey, Adam, Bashir, Rumasia, Liu, Libin, Pilch, Paul, McMahon, Harvey, Robinson, Phillip J., Hancock, John F., Mayor, Satyajit and Parton, Robert G. (2010). Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. Journal of Cell Biology, 190 (4), 675-691. doi: 10.1083/jcb.201002119

Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formation

Ariotti, Nicholas, Liang, Hong, Xu, Yufei, Zhang, Yueqiang, Yonekubo, Yoshiya, Inder, Kerry, Du, Guangwei, Parton, Robert G., Hancock, John F. and Plowman, Sarah J. (2010). Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formation. Molecular and Cellular Biology, 30 (15), 3795-3804. doi: 10.1128/MCB.01615-09

Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis

Howes, Mark T., Mayor, Satyajit and Parton, Robert G. (2010). Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis. Current Opinion In Cell Biology, 22 (4), 519-527. doi: 10.1016/j.ceb.2010.04.001

Heterofibrins: Inhibitors of lipid droplet formation from a deep-water southern Australian marine sponge, Spongia (Heterofibria) sp.

Salim, Angela A., Rae, James, Fontaine, Frank, Conte, Melissa M., Khalil, Zeinab, Martin, Sally, Parton, Robert G. and Capon, Robert J. (2010). Heterofibrins: Inhibitors of lipid droplet formation from a deep-water southern Australian marine sponge, Spongia (Heterofibria) sp.. Organic and Biomolecular Chemistry, 8 (14), 3188-3194. doi: 10.1039/c003840g

Mathematical modeling of K-Ras nanocluster formation on the plasma membrane

Tian, Tianhai, Plowman, Sarah J., Parton, Robert G., Kloog, Yoel and Hancock, John F. (2010). Mathematical modeling of K-Ras nanocluster formation on the plasma membrane. Biophysical Journal, 99 (2), 534-543. doi: 10.1016/j.bpj.2010.04.055

Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens

Smutny, Michael, Cox, Hayley L., Leerberg, Joanne M., Kovacs, Eva M., Conti, Mary Anne, Ferguson, Charles, Hamilton, Nicholas A., Parton, Robert G., Adelstein, Robert S. and Yap, Alpha S. (2010). Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens. Nature Cell Biology, 12 (7), 696-702. doi: 10.1038/ncb2072

Uptake and intracellular fate of disulfide-bonded polymer hydrogel capsules for doxorubicin delivery to colorectal cancer cells

Yan, Y, Johnston, APR, Dodds, SJ, Kamphuis, MMJ, Ferguson, C, Parton, RG, Nice, EC, Heath, JK and Caruso, F (2010). Uptake and intracellular fate of disulfide-bonded polymer hydrogel capsules for doxorubicin delivery to colorectal cancer cells. ACS Nano, 4 (5), 2928-2936. doi: 10.1021/nn100173h

Centrobin regulates the assembly of functional mitotic spindles

Jeffery, J. M., Urquhart, A. J., Subramaniam, V. N., Parton, R.G. and Khanna, K.K. (2010). Centrobin regulates the assembly of functional mitotic spindles. Oncogene, 29 (18), 2649-2658. doi: 10.1038/onc.2010.37

Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks

Koutsopoulos, Olga S., Laine, David, Osellame, Laura, Chudakov, Dmitriy M., Parton, Robert G., Frazier, Ann E. and Ryan, Michael T. (2010). Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1803 (5), 564-574. doi: 10.1016/j.bbamcr.2010.03.006

α-Actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle

Quinlan, Kate G. R., Seto, Jane T., Turner, Nigel, Vandebrouck, Aurelie, Floetenmeyer, Matthias, Macarthur, Daniel G., Raftery, Joanna M., Lek, Monkol, Yang, Nan, Parton, Robert G., Cooney, Gregory J. and North, Kathryn N. (2010). α-Actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle. Human Molecular Genetics, 19 (7) ddq010, 1335-1346. doi: 10.1093/hmg/ddq010

Hydrophobic and basic domains target proteins to lipid droplets

Ingelmo-Torres, M, Gonzalez-Moreno, E, Kassan, A, Hanzal-Bayer, M, Tebar, F, Herms, A, Grewal, T, Hancock, J. F., Enrich, C, Bosch, M, Gross, S. P., Parton, R. G. and Pol, A (2009). Hydrophobic and basic domains target proteins to lipid droplets. TRAFFIC, 10 (12), 1785-1801. doi: 10.1111/j.1600-0854.2009.00994.x

Spatiotemporal regulation of early lipolytic signaling in adipocytes

Martin, S, Okano, S, Kistler, C, Fernandez-Rojo, M. A., Hill, M. M. and Parton, R. G. (2009). Spatiotemporal regulation of early lipolytic signaling in adipocytes. Journal of Biologicial Chemistry, 284 (46), 32097-32107. doi: 10.1074/jbc.M109.002675

Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction

Inder, K. L., Lau, C, Loo, D, Chaudhary, N, Goodall, A, Martin, S, Jones, A, van der Hoeven, D, Parton, R. G., Hill, M. M. and Hancock, J. F. (2009). Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction. Journal of Biological Chemistry, 284 (41), 28410-28419. doi: 10.1074/jbc.M109.001537

Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation

Downes, Meredith, Francois, Mathias, Ferguson, Charles, Parton, Robert G. and Koopman, Peter (2009). Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Human Molecular Genetics, 18 (15), 2839-2850. doi: 10.1093/hmg/ddp219

Lipid droplet-organelle interactions; sharing the fats

Murphy, Samantha, Martin, Sally and Parton, Robert G. (2009). Lipid droplet-organelle interactions; sharing the fats. BBA - Molecular and Cell Biology of Lipids, 1791 (6), 441-447. doi: 10.1016/j.bbalip.2008.07.004

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

Bastiani, M, Liu, L, Hill, M. M., Jedrychowski, M. P., Nixon, S. J., Lo, H. P., Abankwa, D, Luetterforst, R, Fernandez-Rojo, M, Breen, M. R., Gygi, S. P., Vinten, J, Walser, P. J., North, K. N., Hancock, J. F., Pilch, P. F. and Parton, R. G. (2009). MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. The Journal of Cell Biology, 185 (7), 1259-1273. doi: 10.1083/jcb.200903053

Abnormal Nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-Deficient zebrafish

De Jong-Curtain, Tanya A., Parslow, Adam C., Trotter, Andrew J., Hall , Nathan E., Verkade, Heather, Tabone, Tania, Christie, Elizabeth L., Crowhurst, Meredith O., Layton, Judith E., Shepherd, Iain T., Nixon, Susan J., Parton, Robert G., Zon. Leonard I., Stainier, Didier Y.R., Lieschke, Graham J. and Heath, Joan K. (2009). Abnormal Nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-Deficient zebrafish. Gastroenterology, 136 (3), 902-911.e7. doi: 10.1053/j.gastro.2008.11.012

Annexin A2-dependent polymerization of actin mediates endosome biogenesis

Morel, E, Parton, R. G. and Gruenberg, J (2009). Annexin A2-dependent polymerization of actin mediates endosome biogenesis. Developmental Cell, 16 (3), 445-457. doi: 10.1016/j.devcel.2009.01.007

A single method for cryofixation and correlative light, electron microscopy and tomography of zebrafish embryos

Nixon, S. J., Webb, R. I., Floetenmeyer, M., Schieber, N., Lo, H. P. and Parton, R.G. (2009). A single method for cryofixation and correlative light, electron microscopy and tomography of zebrafish embryos. Traffic, 10 (2), 131-136. doi: 10.1111/j.1600-0854.2008.00859.x

Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages

Irvine, Katharine M., Andrews, Melanie R., Fernandez-Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A. and Sweet, Matthew J. (2009). Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology, 85 (2), 278-288. doi: 10.1189/jlb.0808497

Cytoskeletal Tropomyosin Tm5NM1 Is Required for Normal Excitation–Contraction Coupling in Skeletal Muscle

Vlahovich, Nicole, Kee, Anthony J., Van der Pool, Chris, Kettle, Emma, Hernandez-Deviez, Delia, Lucas, Christine, Lynch, Gordon S., Parton, Robert G., Gunning, Peter W. and Hardeman, Edna C. (2009). Cytoskeletal Tropomyosin Tm5NM1 Is Required for Normal Excitation–Contraction Coupling in Skeletal Muscle. Molecular biology of the cell, 20 (1), 400-409. doi: 10.1091/mbc.E08-06-0616

Caveolin regulates endocytosis of the muscle repair protein, dysferlin

Hernandez-Deviez, D. J., Howes, M. T., Laval, S. H., Bushby, K., Hancock, J. F. and Parton, R. G. (2008). Caveolin regulates endocytosis of the muscle repair protein, dysferlin. Journal of Biological Chemistry, 283 (10), 6476-6488. doi: 10.1074/jbc.M708776200

Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2α on neurosecretory vesicles

Wen, Peter, Osborne, Shona L., Morrow, Isabel C., Parton, Robert G., Domin, Jan and Meunier, Frederic A. (2008). Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2α on neurosecretory vesicles. Molecular Biology of the Cell, 19 (12), 5593-5603. doi: 10.1091/mbc.E08-06-0595

The GTPase-Activating Protein GRAF1 regulates the CLIC/GEEC Endocytic Pathway

Lundmark, R., Doherty, G. J., Howes, M. T., Cortese, K., Vallis, Y., Parton, R. G. and McMahon, H. T. (2008). The GTPase-Activating Protein GRAF1 regulates the CLIC/GEEC Endocytic Pathway. Current Biology, 18 (22), 1802-1808. doi: 10.1016/j.cub.2008.10.044

Lysobisphosphatidic acid controls endosomal cholesterol levels

Chevallier, J., Chamoun, Z., Jiang, G., Prestwich, G., Sakai, N., Matile, S., Parton, R. G. and Gruenberg, J. (2008). Lysobisphosphatidic acid controls endosomal cholesterol levels. Journal of Biological Chemistry, 283 (41), 27871-27880. doi: 10.1074/jbc.M801463200

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

Pons, Véronique, Luyet, Pierre-Philippe, Morel, Etienne, Abrami, Laurence, van der Goot, F. Gisou, Parton, Robert G. and Gruenberg, Jean (2008). Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biology, 6 (9) e214, 1942-1956. doi: 10.1371/journal.pbio.0060214

Activation of the MAPK Module from Different Spatial Locations Generates Distinct System Outputs

Inder, K., Harding, A., Plowman, S. J., Philips, M. R., Parton, R. G. and Hancock, J. F. (2008). Activation of the MAPK Module from Different Spatial Locations Generates Distinct System Outputs. Molecular Biology of the Cell, 19 (11), 4776-4784. doi: 10.1091/mbc.E08-04-0407

Electrostatic interactions positively regulate K-Ras nanocluster formation and function

Plowman, S. J., Ariotti, N., Goodall, A., Parton, R. G. and Hancock, J. F. (2008). Electrostatic interactions positively regulate K-Ras nanocluster formation and function. Molecular and Cellular Biology, 28 (13), 4377-4385. doi: 10.1128/MCB.00050-08

Evolutionary analysis and molecular dissection of caveola biogenesis

Kirkham, Matthew, Nixon, Susan J., Howes, Mark T., Abi-Rached, Laurent, Wakeham, Diane E., Hanzal-Bayer, Michael, Ferguson, Charles, Hill, Michelle M., Fernandez-Rojo, Manuel, Brown, Deborah A., Hancock, John F., Brodsky, Frances M. and Parton, Robert G. (2008). Evolutionary analysis and molecular dissection of caveola biogenesis. Journal of Cell Science, 121 (12), 2075-2086. doi: 10.1242/jcs.024588

High-resolution 3D quantitative analysis of caveolar ultrastructure and caveola-cytoskeleton interactions

Richter, T., Floetenmeyer, M., Ferguson, C., Galea, J., Goh, J., Lindsay, M. R., Morgan, G. P., Marsh, B. J. and Parton, R. G. (2008). High-resolution 3D quantitative analysis of caveolar ultrastructure and caveola-cytoskeleton interactions. Traffic, 9 (6), 893-939. doi: 10.1111/j.1600-0854.2008.00733.x

A novel switch region regulated H-ras membrane orientation and signal output

Abankwa, Daniel, Hanzal-Bayer, Michael, Ariotti, Nicolas, Plowman, Sarah J., Gorfe, Alemayehu A, Parton, Robert G., McCammon, J. Andrew and Hancock, John F. (2008). A novel switch region regulated H-ras membrane orientation and signal output. The EMBO journal, 27 (5), 727-735. doi: 10.1038/emboj.2008.10

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

Fei, Weihua, Shui, Guanghou, Gaeta, Bruno, Du, Ximing, Kuerschner, Lars, Li, Peng, Brown, Andrew J, Wenk, Markus R, Parton, Robert G and Yang, Hongyuan (2008). Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. Journal of Cell Biology, 180 (3), 473-482. doi: 10.1083/jcb.200711136

PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function

Hill, M. M., Bastiani, M., Luetterforst, R., Kirkham, M., Kirkham, A., Nixon, S. J., Walser, P., Abankwa, D., Oorschot, V. M., Martin, S., Hancock, J. F. and Parton, R. G. (2008). PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell, 132 (1), 113-124. doi: 10.1016/j.cell.2007.11.042

Characterization of Rab18, a lipid droplet-associated small GTPase

Martin, S and Parton, R. G. (2008). Characterization of Rab18, a lipid droplet-associated small GTPase. Methods in Enzymology, 438, 109-129. doi: 10.1016/S0076-6879(07)38008-7

Cholesterol Manipulation by West Nile Virus Perturbs the Cellular Immune Response

Mackenzie, Jason M., Khromykh, Alexander and Parton, Robert G. (2007). Cholesterol Manipulation by West Nile Virus Perturbs the Cellular Immune Response. Cell Host and Microbe, 2 (4), 229-239. doi: 10.1016/j.chom.2007.09.003

Reassessing the Role of Phosphocaveolin-1 in Cell Adhesion and Migration

Hill, Michelle M., Scherbakov, Nadja, Schiefermeier, Natalia, Baran, JoAnne, Hancock, John F., Huber, Lukas A., Parton, Robert G. and Parat, Marie-Odile (2007). Reassessing the Role of Phosphocaveolin-1 in Cell Adhesion and Migration. Traffic, 8 (12), 1695-1705. doi: 10.1111/j.1600-0854.2007.00653.x

Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking

Sobo, Komla, Le Blanc, Isabelle, Luyet, Pierre-Philippe, Fivaz, Marc, Ferguson, Charles, Parton, Robert G., Gruenberg, Jean and van der Goot, F. Gisou (2007). Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking. PLoS One, 2 (9) e851, e851. doi: 10.1371/journal.pone.0000851

Plasma membrane nanoswitches generate high-fidelity Ras signal transduction

Tian, T. H., Harding, A., Inder, K., Plowman, S., Parton, R. G. and Hancock, J. F. (2007). Plasma membrane nanoswitches generate high-fidelity Ras signal transduction. Nature Cell Biology, 9 (8), 905-914. doi: 10.1038/ncb1615

Cholesterol-Sensitive Cdc42 Activation Regulates Actin Polymerization for Endocytosis via the GEEC Pathway

Chadda, Rahul, Howes, Mark T., Plowman, Sarah J., Hancock, John F., Parton, Robert G. and Mayor, Satyajit (2007). Cholesterol-Sensitive Cdc42 Activation Regulates Actin Polymerization for Endocytosis via the GEEC Pathway. Traffic, 8 (6), 702-717. doi: 10.1111/j.1600-0854.2007.00565.x

Diversity of raft-like domains in late endosomes

Sobo, Komla, Chevallier, Julien, Parton, Robert G., Gruenberg, Jean and van der Goot, F. Gisou (2007). Diversity of raft-like domains in late endosomes. PLoS ONE, 2 (4) e391, e391.1-e391.7. doi: 10.1371/journal.pone.0000391

The multiple faces of caveolae

Parton, R. G. and Simons, K. (2007). The multiple faces of caveolae. Nature Reviews Molecular Cell Biology, 8 (3), 185-194. doi: 10.1038/nrm2122

A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance

Gueven, N, Becherel, OJ, Howe, O, Chen, P, Haince, JF, Ouellet, ME, Poirier, GG, Waterhouse, N, Fusser, M, Epe, B, de Murcia, JM, de Murcia, G, McGowan, CH, Parton, R, Mothersill, C, Grattan-Smith, P and Lavin, MF (2007). A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance. Cell Death And Differentiation, 14 (6), 1149-1161. doi: 10.1038/sj.cdd.4402116

Caveolin-1 is required for lateral line neuromast and notochord development

Nixon, S. J., Carter, A., Wegner, J., Ferguson, C., Floetenmeyer, M., Riches, J. D., Key, B., Westerfield, M. and Parton, R. G. (2007). Caveolin-1 is required for lateral line neuromast and notochord development. Journal of Cell Science, 120 (13), 2151-2161. doi: 10.1242/jcs.003830

Visualisation of macropinosome maturation by the recruitment of sorting nexins

Kerr, Markus C., Lindsay, Margaret R., Luetterforst, Robert, Hamilton, Nicholas, Simpson, Fiona, Parton, Robert G., Gleeson, Paul A. and Teasdale, Rohan D. (2006). Visualisation of macropinosome maturation by the recruitment of sorting nexins. Journal Of Cell Science, 119 (19), 3967-3980. doi: 10.1242/jcs.03167

Caveolin-1 is essential for liver regeneration

Fernandez, Manuel A., Albor, Cecilia, Ingelmo-Torres, Mercedes, Nixon, Susan J., Ferguson, Charles, Kurzchalia, Teymuras, Tebar, Francesc, Enrich, Carlos, Parton, Robert G. and Pol, Albert (2006). Caveolin-1 is essential for liver regeneration. Science, 313 (5793), 1628-1632. doi: 10.1126/science.1130773

Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3 '-kinase-dependent machinery

Kalia, Manjula, Kumari, Sudha, Chadda, Rahul, Hill, Michelle M., Parton, Robert G. and Mayor, Satyajit (2006). Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3 '-kinase-dependent machinery. Molecular Biology of The Cell, 17 (8), 3689-3704. doi: 10.1091/mbc.E05-10-0980

Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3

Hernandez-Deviez, D. J., Martin, S., Laval, S. H., Lo, H. P., Cooper, S. T., North, K. N., Bushby, K. and Parton, RG (2006). Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3. Human Molecular Genetics, 15 (1), 129-142. doi: 10.1093/hmg/ddi434

Biogenesis of caveolae: a structural model for caveolin-induced domain formation

Parton, RG, Hanzal-Bayer, M and Hancock, JF (2006). Biogenesis of caveolae: a structural model for caveolin-induced domain formation. Journal of Cell Science, 119 (5), 787-796. doi: 10.1242/jcs.02853

Cholesterol-induced caveolin targeting to lipid droplets in adipocytes: A role for caveolar endocytosis

Le Lay, S., Hajduch, E., Lindsay, M. R., Le Liepvre, X., Thiele, C., Ferre, P., Parton, R. G., Kurzchalia, T., Simons, K. and Dugail, I. (2006). Cholesterol-induced caveolin targeting to lipid droplets in adipocytes: A role for caveolar endocytosis. Traffic, 7 (5), 549-561. doi: 10.1111/j.1600-0854.2006.00406.x

Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts

Stehbens, S. J., Paterson, A. D., Crampton, M. S., Shewan, A. M., Ferguson, C., Akhmanova, A., Parton, R. G. and Yap, A. S. (2006). Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts. Journal of Cell Science, 119 (9), 1801-1811. doi: 10.1242/jcs.02903

Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane

Nicolau, Dan V. (Jnr), Burrage, Kevin, Parton, Robert G. and Hancock, John F. (2006). Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane. Molecular and Cellular Biology, 26 (1), 313-323. doi: 10.1128/MCB.26.1.313-323.2006

Lipid droplets: a unified view of a dynamic organelle

Martin, S. and Parton, R. G. (2006). Lipid droplets: a unified view of a dynamic organelle. Nature Reviews Molecular Cell Biology, 7 (5), 373-378. doi: 10.1038/nrm1912

Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo.

Trushina, E., Singh, R. P., Dyer, B., Cao, S., Shah, H., Parton, R. G., Pagano, R. E. and McMurray, T. (2006). Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo.. Human Molecular Genetics, 15 (24), 3578-3591. doi: 10.1093/hmg/ddl434

Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds - Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5

Hryciw, Deanne H., Ekberg, Jenny, Ferguson, Charles, Lee, Aven, Wang, Dongsheng, Parton, Robert G., Pollock, Carol A., Yun, Chris C. and Poronnik, Philip (2006). Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds - Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5. Journal of Biological Chemistry, 281 (23), 16068-16077. doi: 10.1074/jbc.M512559200

Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers (vol 1744, pg 273, 2005)

Kirkham, M and Parton, RG (2005). Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers (vol 1744, pg 273, 2005). Biochimica Et Biophysica Acta-Molecular Cell Research, 1746 (3), 349-363. doi: 10.1016/j.bbamcr.2005.11.005

Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers

Kirkham, Matthew and Parton, Robert G. (2005). Clathrin-independent endocytosis: New insights into caveolae and non-caveolar lipid raft carriers. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1745 (3), 273-286. doi: 10.1016/j.bbamcr.2005.06.002

Individual Palmitoyl Residues Serve Distinct Roles in H-ras Trafficking, Microlocalization, and Signaling

Roy, Sandrine, Plowman, Sarah, Rotblat, Barak, Prior, Ian, Muncke, Cornelia, Grainger, Sarah, Parton, Robert, Henis, Yoav, Kloog, Yoel and Hancock, John (2005). Individual Palmitoyl Residues Serve Distinct Roles in H-ras Trafficking, Microlocalization, and Signaling. Molecular And Cellular Biology, 25 (15), 6722-6733. doi: 10.1128/MCB.25.15.6722-6733.2005

A novel hook-related protein family and the characterization of Hook-related protein 1

Simpson, Fiona, Martin, Sally, Evans, Timothy M., Kerr, Markus, James, David E., Parton, Robert G., Teasdale, Rohan D. and Wicking, Carol (2005). A novel hook-related protein family and the characterization of Hook-related protein 1. Traffic, 6 (6), 442-458. doi: 10.1111/j.1600-0854.2005.00289.x

Caveolin, cholesterol, and lipid bodies

Martin, S. and Parton, R. G. (2005). Caveolin, cholesterol, and lipid bodies. Seminars In Cell & Developmental Biology, 16 (2), 163-174. doi: 10.1016/j.semcdb.2005.01.007

Cholesterol and fatty acids regulate dynamic caveolin trafficking through the golgi complex and between the cell surface and lipid bodies

Pol, Albert, Martin, Sally, Fernandez, Manuel A., Ingelmo-Torres, M., Ferguson, C., Enrich, C. and Parton, R. G. (2005). Cholesterol and fatty acids regulate dynamic caveolin trafficking through the golgi complex and between the cell surface and lipid bodies. Molecular Biology of The Cell, 16 (4), 2091-2105. doi: 10.1091/mbc.E04-08-0737

Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers

Kirkham, Matthew and Parton, Robert G (2005). Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers. Biochimica et biophysica acta, 1746 (3), 349-363. doi: 10.1016/j.bbamcr.2005.11.007

Endosome-to-cytosol transport of viral nucleocapsids

Le Blanc, I., Luyet, P. P., Pons, V., Ferguson, C., Emans, N., Petiot, A., Mayran, N., Demaurex, N., Faure, J., Sadoul, R., Parton, R. G. and Gruenberg, J. (2005). Endosome-to-cytosol transport of viral nucleocapsids. Nature Cell Biology, 7 (7), 653-U25. doi: 10.1038/ncb1269

Flotillins and the PHB domain protein family: Rafts, worms and anaesthetics

Morrow, Isabel C. and Parton, Robert G. (2005). Flotillins and the PHB domain protein family: Rafts, worms and anaesthetics. Traffic, 6 (9), 725-740. doi: 10.1111/j.1600-0854.2005.00318.x

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

Plowman, S. J., Muncke, C., Parton, R. G. and Hancock, J. F. (2005). H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proceedings of The National Academy of Sciences of The United States of America, 102 (43), 15500-15505. doi: 10.1073/pnas.0504114102

Ras plasma membrane signalling platforms

Hancock, J. F. and Parton, R. G. (2005). Ras plasma membrane signalling platforms. Biochemical Journal, 389 (Part 1), 1-11. doi: 10.1042/BJ20050231

Regulated localization of rab18 to lipid droplets - Effects of lipolytic stimulation and inhibition of lipid droplet catabolism

Martin, S., Driessen, K., Nixon, S. J., Zerial, M. and Parton, R. G. (2005). Regulated localization of rab18 to lipid droplets - Effects of lipolytic stimulation and inhibition of lipid droplet catabolism. Journal of Biological Chemistry, 280 (51), 42325-42335. doi: 10.1074/jbc.M506651200

Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles

Kirkham, M., Fujita, A., Chadda, R., Nixon, S. J., Kurzchalia, T. V., Sharma, D. K., Pagano, R. E., Hancock, J. F., Mayor, S. and Parton, R. G. (2005). Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles. Journal of Cell Biology, 168 (3), 465-476. doi: 10.1083/jcb.200407078

Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning

Nixon, S. J., Wegner, J., Ferguson, C., Mery, P. F., Hancock, J. F., Currie, P. D., Key, B., Westerfield, M. and Parton, R. G. (2005). Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning. Human Molecular Genetics, 14 (13), 1727-1743. doi: 10.1093/hmg/ddi179

The Rab5 effector rabankyrin-5 regulates and coordinates different endocytic mechanisms

Schnatwinkel, Carsten, Christoforidis, Savvas, Lindsay, Margaret R., Uttenweiler-Joseph, Sandrine, Wilm, Matthias, Parton, Robert G. and Zerial, Marino (2004). The Rab5 effector rabankyrin-5 regulates and coordinates different endocytic mechanisms. Plos Biology, 2 (9), 1363-1380. doi: 10.1371/journal.pbio.0020261

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

Miaczynska, M., Christoforidis, S., Giner, A., Shevchenko, A., Uttenweiler-Joseph, S., Habermann, B., Wilm, M., Parton, R. G. and Zerial, M. (2004). APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell, 116 (3), 445-456. doi: 10.1016/S0092-8674(04)00117-5

Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha

Mounier, C. M., Ghomashchi, F., Lindsay, M. R., James, S., Singer, A. G., Parton, R. G. and Gelb, M. H. (2004). Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha. Journal of Biological Chemistry, 279 (24), 25024-25038. doi: 10.1074/jbc.M313019200

Association of stomatin with lipid bodies

Umlauf, E., Csaszar, E., Moertelmaier, M., Schuetz, G. J., Parton, R. G. and Prohaska, R. (2004). Association of stomatin with lipid bodies. Journal of Biological Chemistry, 279 (22), 23699-23709. doi: 10.1074/jbc.M310546200

Caveolae meet endosomes: A stable relationship?

Parton, RG (2004). Caveolae meet endosomes: A stable relationship?. Developmental Cell, 7 (4), 458-460. doi: 10.1016/j.devcel.2004.09.009

Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration

Towler, Mhairi C., Gleeson, Paul A., Hoshino, Sachiko, Rahkila, Paavo, Manalo, Venus, Ohkoshi, Norio, Ordahl, Charles, Parton, Robert G. and Brodsky, Frances M. (2004). Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. Molecular Biology of The Cell, 15 (7), 3181-3195. doi: 10.1091/mbc.E04-03-0249

Dynamic and regulated association of caveolin with lipid bodies: Modulation of lipid body motility and function by a dominant negative mutant

Pol, Albert, Martin, Sally, Fernandez, Manuel A., Ferguson, Charles, Carozzi, Amanda, Luetterforst, Robert, Enrich, Carlos and Parton, Robert G. (2004). Dynamic and regulated association of caveolin with lipid bodies: Modulation of lipid body motility and function by a dominant negative mutant. Molecular Biology of The Cell, 15 (1), 99-110. doi: 10.1091/mbc.E03-06-0368

Expression of caveolin-1 enhances cholesterol efflux in hepatic cells

Fu, Y., Hoang, A., Escher, G., Parton, R. G., Krozowski, Z. and Sviridov, D. (2004). Expression of caveolin-1 enhances cholesterol efflux in hepatic cells. Journal of Biological Chemistry, 279 (14), 14140-14146. doi: 10.1074/jbc.M311061200

Lipid rafts and plasma membrane microorganization: insights from Ras

Parton, R. G. and Hancock, J. F. (2004). Lipid rafts and plasma membrane microorganization: insights from Ras. Trends In Cell Biology, 14 (3), 141-147. doi: 10.1016/j.tcb.2004.02.001

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

Abrami, L., Lindsay, M., Parton, R. G., Leppla, S. H. and van der Goot, F. G. (2004). Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. Journal of Cell Biology, 166 (5), 645-651. doi: 10.1083/jcb.200312072

ROR alpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells - Caveolin-3 and CPT-1 are direct targets of ROR

Lau, P., Nixon, S. J., Parton, R. G. and Muscat, G. E. O. (2004). ROR alpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells - Caveolin-3 and CPT-1 are direct targets of ROR. Journal of Biological Chemistry, 279 (35), 36828-36840. doi: 10.1074/jbc.M404927200

Role of LBPA and Alix in multivesicular liposome formation and endosome organization

Matsuo, H., Chevallier, J., Mayran, N., Le Blanc, I., Ferguson, C., Faure, J., Blanc, N. S., Matile, S., Dubochet, J., Sadoul, M., Parton, R. G., Vilbois, F. and Gruenberg, J. (2004). Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science, 303 (5657), 531-534. doi: 10.1126/science.1092425

Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol

Sharma, D. K., Brown, J. C., Choudhury, A., Peterson, T. E., Holicky, E., Marks, D. L., Simari, R., Parton, R. G. and Pagano, R. E. (2004). Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol. Molecular Biology of The Cell, 15 (7), 3114-3122. doi: 10.1091/mbc.E04-03-0189

Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane

Rotblat, B., Prior, I. A., Muncke, C., Parton, R. G., Kloog, Y., Henis, Y. I. and Hancock, J. F. (2004). Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Molecular And Cellular Biology, 24 (15), 6799-6810. doi: 10.1128/MCB.24.15.6799-6810.2004

The trans-membrane protein p25 forms highly specialized domains that regulate membrane composition and dynamics

Emery, Gregory, Parton, Robert G., Rojo, Manuel and Gruenberg, Jean (2003). The trans-membrane protein p25 forms highly specialized domains that regulate membrane composition and dynamics. Journal of Cell Science, 116 (23), 4821-4832. doi: 10.1242/jcs.00802

Lipid rafts and caveolae as portals for endocytosis: New insights and common mechanisms

Parton, R. G. and Richards, A. A. (2003). Lipid rafts and caveolae as portals for endocytosis: New insights and common mechanisms. Traffic, 4 (11), 724-738. doi: 10.1034/j.1600-0854.2003.00128.x

Characterization of E-cadherin endocytosis in isolated MCF-7 and Chinese hamster ovary cells - The initial fate of unbound E-cadherin

Paterson, Andrew D., Parton, Robert G., Ferguson, Charles, Stow, Jennifer L. and Yap, Alpha S. (2003). Characterization of E-cadherin endocytosis in isolated MCF-7 and Chinese hamster ovary cells - The initial fate of unbound E-cadherin. Journal of Biological Chemistry, 278 (23), 21050-21057. doi: 10.1074/jbc.M300082200

Observing Cell Surface Signaling Domains Using Electron Microscopy

Prior, I. A., Parton, R. G. and Hancock, J. F. (2003). Observing Cell Surface Signaling Domains Using Electron Microscopy. Science Signaling, 2003 (177), pl9-pl9. doi: 10.1126/stke.2003.177.pl9

Caveolae — from ultrastructure to molecular mechanisms

Parton, Robert G. (2003). Caveolae — from ultrastructure to molecular mechanisms. Nature Reviews Molecular Cell Biology, 4 (2), 162-167. doi: 10.1038/nrm1017

Annexin II regulates multivesicular endosome biogenesis in the degradation pathway of animal cells

Mayran, N., Parton, R. G. and Gruenberg, J. (2003). Annexin II regulates multivesicular endosome biogenesis in the degradation pathway of animal cells. Embo Journal, 22 (13), 3242-3253. doi: 10.1093/emboj/cdg321

Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane

Wyse, B. D., Prior, I. A., Qian, H. W., Morrow, I. C., Nixon, S., Muncke, C., Kurzchalia, T. V., Thomas, W. G., Parton, R. G. and Hancock, J. F. (2003). Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. Journal of Biological Chemistry, 278 (26), 23738-23746. doi: 10.1074/jbc.M212892200

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

Prior, I. A., Muncke, C., Parton, R. G. and Hancock, J. F. (2003). Direct visualization of Ras proteins in spatially distinct cell surface microdomains. Journal of Cell Biology, 160 (2), 165-170. doi: 10.1083/jcb.200209091

Involvement of caveolin-2 in caveolar biogenesis in MDCK cells

Lahtinen, U., Honsho, M., Parton, R. G., Simons, K. and Verkade, P. (2003). Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. Febs Letters, 538 (1-3), 85-88. doi: 10.1016/S0014-5793(03)00135-2

Observing cell surface signaling domains using electron microscopy

Prior, I. A., Parton, R. G. and Hancock, J. F. (2003). Observing cell surface signaling domains using electron microscopy. Signal Transduction Knowledge Environment, 177, 1-12.

Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway

Evans, T. M., Ferguson, C., Wainwright, B. J., Parton, R. G. and Wicking, C. (2003). Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic, 4 (12), 869-884. doi: 10.1046/j.1600-0854.2003.00141.x

Inhibitors of COP-mediated Transport and Cholera Toxin Action Inhibit Simian Virus 40 Infection

Richards, Ayanthi A., Stang, Espen, Pepperkok, Rainer and Parton, Robert G. (2002). Inhibitors of COP-mediated Transport and Cholera Toxin Action Inhibit Simian Virus 40 Infection. Molecular Biology of The Cell, 13 (5), 1750-1764. doi: 10.1091/mbc.01-12-0592

Characterization of a distinct plasma membrane macrodomain in differentiated adipocytes

Parton, R. G., Molero, Juan Carlos, Floetenmeyer, Matthias, Green, Kathryn M. and James, David E. (2002). Characterization of a distinct plasma membrane macrodomain in differentiated adipocytes. Journal of Biological Chemistry, 277 (48), 46769-46778. doi: 10.1074/jbc.M205683200

Differential sorting and fate of endocytosed GPI-anchored proteins

Fivaz, M., Vilbois, F., Thurnheer, S., Pasquali, C., Abrami, L., Bickel, P. E., Parton, R. G. and van der Goot, F. G. (2002). Differential sorting and fate of endocytosed GPI-anchored proteins. Embo Journal, 21 (15), 3989-4000. doi: 10.1093/emboj/cdf398

Flotillin-1/Reggie-2 traffics to surface raft domains via a novel Golgi-independent pathway - Identification of a novel membrane targeting domain and a role for palmitoylation

Morrow, I. C., Rea, S., Martin, S., Prior, I. A., Prohaska, R., Hancock, J. F., James, D. E. and Parton, R. G. (2002). Flotillin-1/Reggie-2 traffics to surface raft domains via a novel Golgi-independent pathway - Identification of a novel membrane targeting domain and a role for palmitoylation. Journal of Biological Chemistry, 277 (50), 48834-48841. doi: 10.1074/jbc.M209082200

GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway

Sabharanjak, Shefali, Sharma, Pranav, Parton, Robert G. and Mayor, Satyajit (2002). GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway. Developmental Cell, 2 (4), 411-423. doi: 10.1016/S1534-5807(02)00145-4

Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3

Carozzi, A. J., Roy, S., Morrow, I. C., Pol, A., Wyse, B., Clyde-Smith, J., Prior, I. A., Nixon, S. J., Hancock, J. F. and Parton, R. G. (2002). Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3. Journal of Biological Chemistry, 277 (20), 17944-17949. doi: 10.1074/jbc.M110879200

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel golgi-associated protein

Harvey, K. F., Shearwin-Whyatt, L. M., Fotia, A., Parton, R. G. and Kumar, S. (2002). N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel golgi-associated protein. Journal of Biological Chemistry, 277 (11), 9307-9317. doi: 10.1074/jbc.M110443200

A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance

Pol, Albert, Luetterforst, Robert, Lindsay, Margaret, Heino, Sanna, Ikonen, Elina and Parton, Robert G. (2001). A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. Journal of Cell Biology, 152 (5), 1057-1070. doi: 10.1083/jcb.152.5.1057

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

Prior, Ian A., Harding, Angus, Yan, Jun, Sluimer, Judith, Parton, Robert G. and Hancock, John F. (2001). GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nature Cell Biology, 3 (4), 368-375. doi: 10.1038/35070050

A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold MP1 on a late endosomal/lysosomal compartment

Wunderlich, Winfried, Fialka, Irene, Teis, David, Alpi, Arno, Pfeifer, Andrea, Parton, Robert G., Lottspeich, Friedrich and Huber, Lukas A. (2001). A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold MP1 on a late endosomal/lysosomal compartment. Journal of Cell Biology, 152 (4), 765-776. doi: 10.1083/jcb.152.4.765

Caveolin and Ras function

Parton, R. G. and Hancock, J. F. (2001). Caveolin and Ras function. Methods in Enzymology, 333, 172-183. doi: 10.1016/S0076-6879(01)33055-0

Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains

Fivaz, M., Abrami, L., Kobayashi, T., Kinoshita, T., Parton, R. G. and van der Groot, G. F. (2001). Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains. The Journal of Biological Chemistry, 276 (33), 30729-30736. doi: 10.1074/jbc.M102039200

Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copperATPase

La Fontaine, S., Theophilos, M. B., Firth, S. D., Gould, R., Parton, R. G. and Mercer, J. F. B. (2001). Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copperATPase. Human Molecular Genetics, 10 (4), 361-370. doi: 10.1093/hmg/10.4.361

Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes

Dermine, J. F., Duclos, S., Garin, J., St-Louis, F., Rea, S., Parton, R. G. and Desjardins, M. (2001). Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes. Journal of Biological Chemistry, 276 (21), 18507-18512. doi: 10.1074/jbc.M101113200

Life without caveolae

Parton, R. G. (2001). Life without caveolae. Science, 293 (5539), 2404-2405. doi: 10.1126/science.1065677

N4WBP5, a potential target for ubiquitination by the nedd4 family of oriteins, is a novel golgi-associated protein

Harvey, K.F., Shearwin-Whyatt, L.M., Fotia, A., Parton, R. G. and Kimar, S. (2001). N4WBP5, a potential target for ubiquitination by the nedd4 family of oriteins, is a novel golgi-associated protein. The Journal of biological chemistry, 277 (11), 9307-9317.

Protein targeting to the plasma membrane of adult skeletal muscle fiber: An organized mosaic of functional domains

Rahkila, P., Takala, T. E. S., Parton, R. G. and Metsikko, K. (2001). Protein targeting to the plasma membrane of adult skeletal muscle fiber: An organized mosaic of functional domains. Experimental Cell Research, 267 (1), 61-72. doi: 10.1006/excr.2001.5101

Which Ras rides the raft? - Reply

Prior, I. A., Parton, R. G. and Hancock, J. F. (2001). Which Ras rides the raft? - Reply. Nature Cell Biology, 3 (8), E172-E172. doi: 10.1038/35087100

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

Gillooly, D. J., Morrow, I. C., Lindsay, M., Gould, R., Bryant, N. J., Gaullier, J. M., Parton, R. G. and Stenmark, H. (2000). Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO Journal, 19 (17), 4577-4588. doi: 10.1093/emboj/19.17.4577

Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and is required for late endosome-lysosome fusion

Mullock, Barbara M. M, Smith, Chez W., Ihrke, Gudrun, Bright, Nicholas A., Lindsay, Margaret, Parkinson, Emma J., Brooks, Doug A., Parton, Robert G., James, David E., Luzio, J. Paul and Piper, Robert C. (2000). Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and is required for late endosome-lysosome fusion. Molecular Biology of the Cell, 11 (9), 3137-3153. doi: 10.1091/mbc.11.9.3137

The growth suppressing gas1 product is a GPI-linked protein

Stebel, M, Vatta, P, Ruaro, ME, Del Sal, G, Parton, RG and Schneider, C (2000). The growth suppressing gas1 product is a GPI-linked protein. Febs Letters, 481 (2), 152-158. doi: 10.1016/S0014-5793(00)02004-4

EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts

Wilson, Jean M., de Hoop, Meltsje, Zorzi, Natasha, Toh, Ban-Hock, Dotti, Carlos G. and Parton, Robert G. (2000). EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts. Molecular Biology of the Cell, 11 (8), 2657-2671. doi: 10.1091/mbc.11.8.2657

The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components

Gagescu, Raluca, Demaurex, Nicolas, Parton, Robert G., Hunziker, Walter, Huber, Lukas A. and Gruenberg, Jean (2000). The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components. Molecular Biology of the Cell, 11 (8), 2775-2791. doi: 10.1091/mbc.11.8.2775

The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells

Kobayashi, Toshihide, Vischer, Ulrich M., Rosnoblet, Corinne, Lebrand, Cecile, Lindsay, Margaret, Parton, Robert G., Kruithof, Egbert K. O. and Gruenberg, Jean (2000). The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells. Molecular Biology of the Cell, 11 (5), 1829-1843. doi: 10.1091/mbc.11.5.1829

Role of cholesterol in developing T-tubules: Analogous mechanisms for T-tubule and caveolae biogenesis

Carozzi, A. J., Ikonen, E., Lindsay, M. R. and Parton, R. G. (2000). Role of cholesterol in developing T-tubules: Analogous mechanisms for T-tubule and caveolae biogenesis. Traffic, 1 (4), 326-341. doi: 10.1034/j.1600-0854.2000.010406.x

Caveolins and cellular cholesterol balance

Ikonen, E. and Parton, R. G. (2000). Caveolins and cellular cholesterol balance. Traffic, 1 (3), 212-217. doi: 10.1034/j.1600-0854.2000.010303.x

Interaction of anti-phospholipid antibodies with late endosomes of human endothelial cells

Galve-De Rochemonteix, B., Kobayashi, T., Rosnoblet, C., Lindsay, M., Parton, R. G., Reber, G., de Maistre, E., Wahl, D., Kruithof, E. K. O., Gruenberg, J. and de Moerloose, P. (2000). Interaction of anti-phospholipid antibodies with late endosomes of human endothelial cells. Arteriosclerosis Thrombosis and Vascular Biology, 20 (2), 563-574.

Caves and labyrinths: caveolae and transverse tubules in skeletal muscle

Parton, R. G., Carozzi, A. and Gustavsson, J. (2000). Caves and labyrinths: caveolae and transverse tubules in skeletal muscle. Protoplasma, 212 (1-2), 15-23. doi: 10.1007/BF01279343

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

Apolloni, A., Prior, I. A., Lindsay, M., Parton, R. G. and Hancock, J. F. (2000). H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Molecular & Cellular Biology, 20 (7), 2475-2487. doi: 10.1128/MCB.20.7.2475-2487.2000

The transmembrane protein p23 contributes to the organization of the Golgi apparatus

Rojo, M., Emery, G., Marjomaki, V., McDowall, A. W., Parton, R. G. and Gruenberg, J. (2000). The transmembrane protein p23 contributes to the organization of the Golgi apparatus. Journal of Cell Science, 113 (Pt 6), 1043-1057.

Developmental regulation of microtubule organisation in oligodendrocytes

Gordon, D, Smith, R, Parton, R and Kidd, GJ (1999). Developmental regulation of microtubule organisation in oligodendrocytes. Molecular Biology of The Cell, 10, 265A-265A.

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

Roy, S., Luetterforst, R., Harding, A., Apolloni, A., Etheridge, M., Stang, E., Rolls, B., Hancock, J. F. and Parton, R. G. (1999). Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nature Cell Biology, 1 (2), 98-105. doi: 10.1038/10067

Endocytosis in skeletal muscle fibers

Kaisto, T., Rahkila, P., Marjomaki, V., Parton, R. G. and Metsikko, K. (1999). Endocytosis in skeletal muscle fibers. Experimental Cell Research, 253 (2), 551-560. doi: 10.1006/excr.1999.4659

Exploitation of major histocompatibility complex class I molecules and caveolae by simian virus 40

Parton, R. G. and Lindsay, M. (1999). Exploitation of major histocompatibility complex class I molecules and caveolae by simian virus 40. Immunological Reviews, 168 (1), 23-31. doi: 10.1111/j.1600-065X.1999.tb01280.x

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

Kobayashi, T., Beuchat, M. H., Lindsay, M., Frias, S., Palmiter, R. D., Sakuraba, H., Parton, R. G. and Gruenberg, J. (1999). Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport. Nature Cell Biology, 1 (2), 113-118. doi: 10.1038/10084

Membrane microdomains and caveolae

Kurzchalia, T. V. and Parton, RG (1999). Membrane microdomains and caveolae. Current Opinion in Cell Biology, 11 (4), 424-431. doi: 10.1016/S0955-0674(99)80061-1

Molecular characterization of caveolin association with the golgi complex: Identification of a Cis-Golgi targeting domain in the caveolin molecule

Luetterforst, R., Stang, E., Zorzi, N., Carozzi, A., Way, M. and Parton, R. G. (1999). Molecular characterization of caveolin association with the golgi complex: Identification of a Cis-Golgi targeting domain in the caveolin molecule. Journal of Cell Biology, 145 (7), 1443-1459. doi: 10.1083/jcb.145.7.1443

PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function

Sincock, P. M., Fitter, S., Parton, R. G., Berndt, M., Gamble, J. R. and Ashman, L. K. (1999). PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. Journal of Cell Science, 112 (6), 833-844.

Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes

Pizarro-Cerda, Javier, Meresse, Stepahane, Parton, Robert G., van der Goot, Gisou, Sola-Landa, Alberto, Lopez-Goni, Ignacio, Moreno, Edgardo and Gorvel, Jean-Pierre (1998). Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes. Infection and Immunity, 66 (12), 5711-5724. doi: 10.1128/iai.66.12.5711-5724.1998

A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane

Zeng, Qi, Subramaniam, V. Nathan, Wong, Siew Heng, Tang, Bor Luen, Parton, Robert G., Rea, Shane, James, David E. and Hong, Wanjin (1998). A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane. Molecular Biology of The Cell, 9 (9), 2423-2437. doi: 10.1091/mbc.9.9.2423

Functional analysis and intracellular localization of the human Menkes protein (MNK) stably expressed from a cDNA construct in Chinese hamster ovary cells (CHO-K1)

LA Fontaine, S., Firth, S. D., Lockhart, P. J., Brooks, H., Parton, R. G., Camakaris, J. and Mercer, J. F. B. (1998). Functional analysis and intracellular localization of the human Menkes protein (MNK) stably expressed from a cDNA construct in Chinese hamster ovary cells (CHO-K1). Human Molecular Genetics, 7 (8), 1293-1300. doi: 10.1093/hmg/7.8.1293

A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

Kobayashi, T., Stang, E., Fang, K. S., de Moerloose, P., Parton, R. G. and Gruenberg, J. (1998). A lipid associated with the antiphospholipid syndrome regulates endosome structure and function. Nature, 392 (6672), 193-197. doi: 10.1038/32440

Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells

Zacchi, P., Stenmark, H., Parton, R. G., Orioli, D., Lim, F., Giner, A., Mellman, I., Zerial, M. and Murphy, C. (1998). Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells. Journal of Cell Biology, 140 (5), 1039-1053. doi: 10.1083/jcb.140.5.1039

A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum

Abrami, L., Fivaz, M., Glauser, P. E., Parton, R. G. and van der Goot, F. G. (1998). A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum. Journal of Cell Biology, 140 (3), 525-540. doi: 10.1083/jcb.140.3.525

Regulation of caveolin and caveolae by cholesterol in MDCK cells

Hailstones, D., Sleer, L. S., Parton, R. G. and Stanley, K. K. (1998). Regulation of caveolin and caveolae by cholesterol in MDCK cells. Journal of Lipid Research, 39 (2), 369-379. doi: 10.1016/s0022-2275(20)33898-0

Functional dissection of COP-I subunits in the biogenesis of multivesicular endosomes

Gu, F., Aniento, F., Parton, R. G. and Gruenberg, J. (1997). Functional dissection of COP-I subunits in the biogenesis of multivesicular endosomes. Journal of Cell Biology, 139 (5), 1183-1195. doi: 10.1083/jcb.139.5.1183

Involvement of the transmembrane protein p23 in biosynthetic protein transport

Rojo, M., Pepperkok, R., Emery, G., Kellner, R., Stang, E., Parton, R. G. and Gruenberg, J. (1997). Involvement of the transmembrane protein p23 in biosynthetic protein transport. Journal of Cell Biology, 139 (5), 1119-1135. doi: 10.1083/jcb.139.5.1119

HSV infection of polarized epithelial cells on filter supports: Implications for transport assays and protein localization

Murphy, C., Zacchi, P., Parton, R. G., Zerial, M. and Lim, F. (1997). HSV infection of polarized epithelial cells on filter supports: Implications for transport assays and protein localization. European Journal of Cell Biology, 72 (3), 278-281.

Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol

Harder, Thomas, Kellner, Roland, Parton, Robert G. and Gruenberg, Jean (1997). Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol. Molecular Biology of the Cell, 8 (3), 533-545. doi: 10.1091/mbc.8.3.533

Caveolin-3 associates with developing T-tubules during muscle differentiation

Parton, R. G., Way, M., Zorzi, N. and Stang, E. (1997). Caveolin-3 associates with developing T-tubules during muscle differentiation. Journal of Cell Biology, 136 (1), 137-154. doi: 10.1083/jcb.136.1.137

Major histocompatibility complex class I molecules mediate association of SV40 with caveolae

Stang, Espen, Kartenbeck, Juergen and Parton, Robert G. (1997). Major histocompatibility complex class I molecules mediate association of SV40 with caveolae. Molecular Biology of the Cell, 8 (1), 47-57. doi: 10.1091/mbc.8.1.47

Endosome dynamics regulated by a Rho protein

Murphy, C, Saffrich, R, Grummt, W, Gournier, H, Rybin, V, Rubino, M, Auvinen, P, Lutcke, A, Parton, RG and Zerial, M (1996). Endosome dynamics regulated by a Rho protein. Nature, 384 (6608), 427-432. doi: 10.1038/384427a0

Rab11 regulates recycling through the pericentriolar recycling endosome

Ullrich, O., Reinsch, S., Urbe, S., Zerial, M. and Parton, R. G. (1996). Rab11 regulates recycling through the pericentriolar recycling endosome. Journal of Cell Biology, 135 (4), 913-924. doi: 10.1083/jcb.135.4.913

The association of annexin I with early endosomes is regulated by Ca2+ and requires an intact N-terminal domain

Seemann, Joachim, Weber, Klaus, Osborn, Mary, Parton, Robert G. and Gerke, Volker (1996). The association of annexin I with early endosomes is regulated by Ca2+ and requires an intact N-terminal domain. Molecular Biology of the Cell, 7 (9), 1359-1374. doi: 10.1091/mbc.7.9.1359

Caveolae and caveolins

Parton, RG (1996). Caveolae and caveolins. Current Opinion in Cell Biology, 8 (4), 542-548. doi: 10.1016/S0955-0674(96)80033-0

Analysis of the role of p200-containing vesicles in post-Golgi traffic

Ikonen, Elina, Parton, Robert G., Lafont, Frank and Simons, Kai (1996). Analysis of the role of p200-containing vesicles in post-Golgi traffic. Molecular Biology of the Cell, 7 (6), 961-974. doi: 10.1091/mbc.7.6.961

And still they are moving ... Dynamic properties of caveolae

Kurzchalia, TV and Parton, RG (1996). And still they are moving ... Dynamic properties of caveolae. Febs Letters, 389 (1), 52-54. doi: 10.1016/0014-5793(96)00585-6

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes

Aniento, F., Gu, F., Parton, R. G. and Gruenberg, J. (1996). An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes. Journal of Cell Biology, 133 (1), 29-41. doi: 10.1083/jcb.133.1.29

M-caveolin, a muscle specific caveolin-related protein (vol 376, pg 108, 1995)

Way, M and Parton, RG (1996). M-caveolin, a muscle specific caveolin-related protein (vol 376, pg 108, 1995). Febs Letters, 378 (1), 101-106.

M-caveolin, a muscle-specific caveolin-related protein

Way, Michael and Parton, Robert G. (1996). M-caveolin, a muscle-specific caveolin-related protein. FEBS Letters, 378 (1), 108-112. doi: 10.1016/0014-5793(96)82884-5

Erratum: M-caveolin, a muscle specific caveolin-related protein (FEBS Letters 376 (1995) (108-112))

Way, M. and Parton, R. G. (1996). Erratum: M-caveolin, a muscle specific caveolin-related protein (FEBS Letters 376 (1995) (108-112)). FEBS Letters, 378 (1), 101-112. doi: 10.1016/0014-5793(96)82883-3

M-Caveolin, a Muscle-Specific Caveolin-Related Protein

Way, M. and Parton, R. G. (1995). M-Caveolin, a Muscle-Specific Caveolin-Related Protein. Febs Letters, 376 (1-2), 108-112. doi: 10.1016/0014-5793(95)01256-7

The organization of the endoplasmic reticulum and the intermediate compartment in cultured rat hippocampal neurons

Krijnse-locker, Jacomine, Parton, Robert G., Fuller, Stephen D., Griffiths, Gareth and Dotti, Carlos G. (1995). The organization of the endoplasmic reticulum and the intermediate compartment in cultured rat hippocampal neurons. Molecular Biology of the Cell, 6 (10), 1315-1332. doi: 10.1091/mbc.6.10.1315

De-Novo Formation of Caveolae in Lymphocytes by Expression of Vip21-Caveolin

Fra, A. M., Williamson, E., Simons, K. and Parton, R. G. (1995). De-Novo Formation of Caveolae in Lymphocytes by Expression of Vip21-Caveolin. Proceedings of the National Academy of Sciences of the United States of America, 92 (19), 8655-8659. doi: 10.1073/pnas.92.19.8655

Digging Into Caveolae

Parton, R. G. and Simons, K. (1995). Digging Into Caveolae. Science, 269 (5229), 1398-1399. doi: 10.1126/science.7660120

Rapid Processing of Filter-Grown Cells for Epon Embedding

Parton, R. G. (1995). Rapid Processing of Filter-Grown Cells for Epon Embedding. Journal of Histochemistry & Cytochemistry, 43 (7), 731-733. doi: 10.1177/43.7.7608529

Vip21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro

Monier, Solange, Parton, Robert G., Vogel, Frank, Behlke, Joachim, Henske, Annemarie and Kurzchalia, Teymuras V. (1995). Vip21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro. Molecular Biology of the Cell, 6 (7), 911-927. doi: 10.1091/mbc.6.7.911

EEA1, an early endosome-associated protein: EEA1 is a conserved α-helical peripheral membrane-protein flanked by cysteine fingers and contains a calmodulin-binding IQ motif

Mu, Fi-Tjen, Callaghan, Judy M., Steelemortimer, Olivia, Stenmark, Harald, Parton, Robert G., Campbell, Paul L., McCluskey, James, Yeo, Jing-Ping, Tock, Edward P. C. and Toh, Ban-Hock (1995). EEA1, an early endosome-associated protein: EEA1 is a conserved α-helical peripheral membrane-protein flanked by cysteine fingers and contains a calmodulin-binding IQ motif. Journal of Biological Chemistry, 270 (22), 13503-13511. doi: 10.1074/jbc.270.22.13503

Nocodazole-Dependent Transport, and Brefeldin A-Sensitive Processing and Sorting, of Newly Synthesized Membrane-Proteins in Cultured Neurons

Cidarregui, A., Parton, R. G., Simons, K. and Dotti, C. G. (1995). Nocodazole-Dependent Transport, and Brefeldin A-Sensitive Processing and Sorting, of Newly Synthesized Membrane-Proteins in Cultured Neurons. Journal of Neuroscience, 15 (6), 4259-4269.

Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane

Fiedler, K., Lafont, F., Parton, R. G. and Simons, K. (1995). Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane. Journal of Cell Biology, 128 (6), 1043-1053. doi: 10.1083/jcb.128.6.1043

Prohibitin, An Antiproliferative Protein, Is Localized to Mitochondria

Ikonen, E, Fiedler, K, Parton, RG and Simons, K (1995). Prohibitin, An Antiproliferative Protein, Is Localized to Mitochondria. Febs Letters, 358 (3), 273-277. doi: 10.1016/0014-5793(94)01444-6

Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae

Fra, Anna M., Williamson, Edward, Simons, Kai and Parton, Robert G. (1994). Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae. Journal of Biological Chemistry, 269 (49), 30745-30748.

Cloning and Subcellular-Localization of Novel Rab Proteins Reveals Polarized and Cell-Type-Specific Expression

Lutcke, A., Parton, R. G., Murphy, C., Olkkonen, V. M., Dupree, P., Valencia, A., Simons, K. and Zerial, M. (1994). Cloning and Subcellular-Localization of Novel Rab Proteins Reveals Polarized and Cell-Type-Specific Expression. Journal of Cell Science, 107, 3437-3448.

Regulated internalization of caveolae

Parton, R. G., Joggerst, B. and Simons, K. (1994). Regulated internalization of caveolae. Journal of Cell Biology, 127 (5), 1199-1215. doi: 10.1083/jcb.127.5.1199

The Involvement of the Small Gtp-Binding Protein Rab5a in Neuronal Endocytosis

Dehoop, MJ, Huber, LA, Stenmark, H, Williamson, E, Zerial, M, Parton, RG and Dotti, CG (1994). The Involvement of the Small Gtp-Binding Protein Rab5a in Neuronal Endocytosis. Neuron, 13 (1), 11-22. doi: 10.1016/0896-6273(94)90456-1

Association of Rap1a and Rap1b Proteins with Late Endocytic/phagocytic Compartments and Rap2a with the Golgi-Complex

Pizon, V., Desjardins, M., Bucci, C., Parton, R. G. and Zerial, M. (1994). Association of Rap1a and Rap1b Proteins with Late Endocytic/phagocytic Compartments and Rap2a with the Golgi-Complex. Journal of Cell Science, 107, 1661-1670.

Vip36, a Novel Component of Glycolipid Rafts and Exocytic Carrier Vesicles in Epithelial-Cells

Fiedler, K., Parton, R. G., Kellner, R., Etzold, T. and Simons, K. (1994). Vip36, a Novel Component of Glycolipid Rafts and Exocytic Carrier Vesicles in Epithelial-Cells. Embo Journal, 13 (7), 1729-1740. doi: 10.1002/j.1460-2075.1994.tb06437.x

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

Desjardins, M., Huber, L. A., Parton, R. G. and Griffiths, G. (1994). Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus. Journal of Cell Biology, 124 (5), 677-688. doi: 10.1083/jcb.124.5.677

Inhibition of Rab5 Gtpase Activity Stimulates Membrane-Fusion in Endocytosis

Stenmark, H., Parton, R. G., Steelemortimer, O., Lutcke, A., Gruenberg, J. and Zerial, M. (1994). Inhibition of Rab5 Gtpase Activity Stimulates Membrane-Fusion in Endocytosis. Embo Journal, 13 (6), 1287-1296. doi: 10.1002/j.1460-2075.1994.tb06381.x

Ultrastructural-Localization of Gangliosides - Gm(1) Is Concentrated in Caveolae

Parton, R. G. (1994). Ultrastructural-Localization of Gangliosides - Gm(1) Is Concentrated in Caveolae. Journal of Histochemistry & Cytochemistry, 42 (2), 155-166. doi: 10.1177/42.2.8288861

Rab11, a Small Gtpase Associated with Both Constitutive and Regulated Secretory Pathways in Pc12-Cells

Urbe, S, Huber, LA, Zerial, M, Tooze, SA and Parton, RG (1993). Rab11, a Small Gtpase Associated with Both Constitutive and Regulated Secretory Pathways in Pc12-Cells. Febs Letters, 334 (2), 175-182. doi: 10.1016/0014-5793(93)81707-7

Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane

Huber, L. A., Pimplikar, S., Parton, R. G., Virta, H., Zerial, M. and Simons, K. (1993). Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. Journal of Cell Biology, 123 (1), 35-45. doi: 10.1083/jcb.123.1.35

Transcytosis of the Polymeric Immunoglobulin Receptor in Cultured Hippocampal-Neurons

Ikonen, E, Parton, RG, Hunziker, W, Simons, K and Dotti, CG (1993). Transcytosis of the Polymeric Immunoglobulin Receptor in Cultured Hippocampal-Neurons. Current Biology, 3 (10), 635-644. doi: 10.1016/0960-9822(93)90061-R

Cell Biology of Neuronal Endocytosis

Parton, R. G. and Dotti, C. G. (1993). Cell Biology of Neuronal Endocytosis. Journal of Neuroscience Research, 36 (1), 1-9. doi: 10.1002/jnr.490360102

Internalization and recycling of activated thrombin receptors

Hoxie, James A., Ahuja, Menaka, Belmonte, Elizabeth, Pizarro, Shelly, Parton, Robert and Brass, Lawrence F. (1993). Internalization and recycling of activated thrombin receptors. Journal of Biological Chemistry, 268 (18), 13756-13763.

Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization

Lutcke, A., Jansson, S., Parton, R. G., Chavrier, P., Valencia, A., Huber, L. A., Lehtonen, E. and Zerial, M. (1993). Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. Journal of Cell Biology, 121 (3), 553-564. doi: 10.1083/jcb.121.3.553

Caveolae and sorting in the trans-Golgi network of epithelial-cells

Dupree, P, Parton, RG, Raposo, G, Kurzchalia, TV and Simons, K (1993). Caveolae and sorting in the trans-Golgi network of epithelial-cells. EMBO Journal, 12 (4), 1597-1605. doi: 10.1002/j.1460-2075.1993.tb05804.x

The immunofluorescent era of membrane traffic

Griffiths, G., Parton, R. G., Lucocq, J., van Deurs, B., Brown, D., Slot, J.W. and Geuze, H. J. (1993). The immunofluorescent era of membrane traffic. Trends in Cell Biology, 3 (7), 214-219. doi: 10.1016/0962-8924(93)90114-G

Axonal and dendritic endocytic pathways in cultured neurons

Parton, R. G., Simons, K. and Dotti, C. G. (1992). Axonal and dendritic endocytic pathways in cultured neurons. Journal of Cell Biology, 119 (1), 123-137. doi: 10.1083/jcb.119.1.123

Plasticity of Early Endosomes

Parton, R. G., Schrotz, P., Bucci, C. and Gruenberg, J. (1992). Plasticity of Early Endosomes. Journal of Cell Science, 103, 335-348.

Interactions of rab5 with cytosolic proteins

Kurzchalia, Teymuras V., Gorvel, Jean-Pierre, Dupree, Paul, Parton, Robert, Kellner, Roland, Houthaeve, Tony, Gruenberg, Jean and Simons, Kai (1992). Interactions of rab5 with cytosolic proteins. Journal of Biological Chemistry, 267 (26), 18419-18423.

The Small Gtpase Rab5 Functions as a Regulatory Factor in the Early Endocytic Pathway

Bucci, C, Parton, RG, Mather, IH, Stunnenberg, H, Simons, K, Hoflack, B and Zerial, M (1992). The Small Gtpase Rab5 Functions as a Regulatory Factor in the Early Endocytic Pathway. Cell, 70 (5), 715-728. doi: 10.1016/0092-8674(92)90306-W

VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles

Kurzchalia, T. V., Dupree, P., Parton, R. G., Kellner, R., Virta, H., Lehnert, M. and Simons, K. (1992). VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. Journal of Cell Biology, 118 (5), 1003-1014. doi: 10.1083/jcb.118.5.1003

Sphingolipid Transport From the Transgolgi Network to the Apical Surface in Permeabilized Mdck Cells

Kobayashi, T, Pimplikar, SW, Parton, RG, Bhakdi, S and Simons, K (1992). Sphingolipid Transport From the Transgolgi Network to the Apical Surface in Permeabilized Mdck Cells. Febs Letters, 300 (3), 227-231. doi: 10.1016/0014-5793(92)80851-7

Axonal and dendritic endocytic pathways in cultured neurons

Parton, Robert G., Simons, Kai and Dotti, Carlos G. (1992). Axonal and dendritic endocytic pathways in cultured neurons. Micron And Microscopica Acta, 23 (1-2), 113-114. doi: 10.1016/0739-6260(92)90095-U

Biogenesis of Cell-Surface Polarity in Epithelial-Cells and Neurons

Simons, K., Dupree, P., Fiedler, K., Huber, L. A., Kobayashi, T., Kurzchalia, T., Olkkonen, V., Pimplikar, S., Parton, R. and Dotti, C. (1992). Biogenesis of Cell-Surface Polarity in Epithelial-Cells and Neurons. Cold Spring Harbor Symposia On Quantitative Biology, 57, 611-619. doi: 10.1101/SQB.1992.057.01.067

Localization of Rab Family Members in Animal-Cells

Zerial, M., Parton, R., Chavrier, P. and Frank, R. (1992). Localization of Rab Family Members in Animal-Cells. Methods in Enzymology, 219, 398-407.

Endocytosis in the Kidney - Insights From the Mdck Cell System

Parton, R. G. and Simons, K. (1991). Endocytosis in the Kidney - Insights From the Mdck Cell System. Seminars in Nephrology, 11 (4), 440-452.

pH-induced microtubule-dependent redistribution of late endosomes in neuronal and epithelial cells

Parton, R. G., Dotti, C. G., Bacallao, R., Kurtz, I., Simons, K. and Prydz, K. (1991). pH-induced microtubule-dependent redistribution of late endosomes in neuronal and epithelial cells. Journal of Cell Biology, 113 (2), 261-274. doi: 10.1083/jcb.113.2.261

Endocytosis in polarized cells

Parton, R. G. (1991). Endocytosis in polarized cells. Seminars in cell biology, 2 (6), 387-395.

Polarized Sorting of Glypiated Proteins in Hippocampal-Neurons

Dotti, C. G., Parton, R. G. and Simons, K. (1991). Polarized Sorting of Glypiated Proteins in Hippocampal-Neurons. Nature, 349 (6305), 158-160. doi: 10.1038/349158a0

Transcytosis in MDCK cells: identification of glycoproteins transported bidirectionally between both plasma membrane domains.

Brandli, A. W., Parton, R. G. and Simons, K. (1990). Transcytosis in MDCK cells: identification of glycoproteins transported bidirectionally between both plasma membrane domains.. Journal of Cell Biology, 111 (6), 2909-2921. doi: 10.1083/jcb.111.6.2909

Microtubule-Dependent and Motor-Dependent Fusion Invitro Between Apical and Basolateral Endocytic Vesicles From Mdck Cells

Bomsel, M, Parton, R, Kuznetsov, SA, Schroer, TA and Gruenberg, J (1990). Microtubule-Dependent and Motor-Dependent Fusion Invitro Between Apical and Basolateral Endocytic Vesicles From Mdck Cells. Cell, 62 (4), 719-731. doi: 10.1016/0092-8674(90)90117-W

Localization of Low-Molecular-Weight Gtp Binding-Proteins to Exocytic and Endocytic Compartments

Chavrier, P, Parton, RG, Hauri, HP, Simons, K and Zerial, M (1990). Localization of Low-Molecular-Weight Gtp Binding-Proteins to Exocytic and Endocytic Compartments. Cell, 62 (2), 317-329. doi: 10.1016/0092-8674(90)90369-P

Endocytosis in filter-grown Madin-Darby canine kidney cells

Bomsel, M., Prydz, K., Parton, R. G., Gruenberg, J. and Simons, K. (1989). Endocytosis in filter-grown Madin-Darby canine kidney cells. Journal of Cell Biology, 109 (6), 3243-3258. doi: 10.1083/jcb.109.6.3243

Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes

Parton, R. G., Prydz, K., Bomsel, M., Simons, K. and Griffiths, G. (1989). Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes. Journal of Cell Biology, 109 (6), 3259-3272. doi: 10.1083/jcb.109.6.3259

Comparison of the Binding Characteristics of 2 Different Preparations of Tetanus Toxin to Rat-Brain Membranes

Parton, RG, Davison, MD and Critchley, DR (1989). Comparison of the Binding Characteristics of 2 Different Preparations of Tetanus Toxin to Rat-Brain Membranes. Toxicon, 27 (1), 127-135. doi: 10.1016/0041-0101(89)90412-1

Tetanus Toxin Binding to Mouse Spinal-Cord Cells - An Evaluation of the Role of Gangliosides in Toxin Internalization

Parton, RG, Ockleford, CD and Critchley, DR (1988). Tetanus Toxin Binding to Mouse Spinal-Cord Cells - An Evaluation of the Role of Gangliosides in Toxin Internalization. Brain Research, 475 (1), 118-127. doi: 10.1016/0006-8993(88)90204-1

A study of the mechanism of internalization of tetanus toxin by primary mouse spinal-cord cultures

Parton, RG, Ockleford, CD and Critchley, DR (1987). A study of the mechanism of internalization of tetanus toxin by primary mouse spinal-cord cultures. Journal of Neurochemistry, 49 (4), 1057-1068. doi: 10.1111/j.1471-4159.1987.tb09994.x

Characterization of Tetanus Toxin Binding to Rat-Brain Membranes - Evidence for a High-Affinity Proteinase-Sensitive Receptor

Pierce, E. J., Davison, M. D., Parton, R. G., Habig, W. H. and Critchley, D. R. (1986). Characterization of Tetanus Toxin Binding to Rat-Brain Membranes - Evidence for a High-Affinity Proteinase-Sensitive Receptor. Biochemical Journal, 236 (3), 845-852. doi: 10.1042/bj2360845

Reactivation of Myc transcription in the heart unlocks its proliferative capacity

Bywater, M. J., Burkhart, D. L., Sabo, A., Straube, J., Pendino, V., Hudson, J. E., Quaife-Ryan, G. A., Porrello, E. R., Rae, J., Parton, R. G., Kress, T. R., Amati, B., Littlewood, T. D., Evan, G. I. and Wilson, C. H. (2020). Reactivation of Myc transcription in the heart unlocks its proliferative capacity. BSCR Autumn meeting, New York, NY, United States: Springer.

A Microtubule Organizing Center Directing Intracellular Transport in the Early Mouse Embryo

Zenker, J., White, M. D., Templin, R. M., Parton, R. G., Thorn-Seshold, O., Bissiere, S. and Plachta, N. (2017). A Microtubule Organizing Center Directing Intracellular Transport in the Early Mouse Embryo. ASCB/EMBO Meeting, Philadelphia Pa United States, 2-6 December 2017. Bethesda, MD United States: American Society for Cell Biology.

A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer

Horvath, Lisa, Lin, Hui-Ming, Mahon, Kate, Weir, Jacquelyn, Mundra, Piyushkumar, Spielman, Calan, Briscoe, Karen, Gurney, Howard, Mallesara, Girish, Marx, Gavin, Stockler, Martin, Parton, Robert, Hoy, Andrew, Daly, Roger and Meikle, Peter (2017). A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer. ANZUP Annual Scientific Meeting: The Art & Science of Best Practice, Melbourne, VIC, Australia, 16–18 July 2017. Hoboken, NJ, United States: Wiley. doi: 10.1111/ajco.12718

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Hudson, J., Mills, R., Titmarsh, D., Koenig, X., Parker, B., Ryall, J., Quaife-Ryan, G., Voges, H., Hodson, M., Ferguson, C., Drowley, L., Plowright, A., Wang, Q., Gregorevic, P., Xin, M., Thomas, W., Parton, R., Nielsen, L., Launikonis, B., James, D., Elliott, D. and Porrello, E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Perth, Australia, 10 - 13 August 2017. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2017.06.375

Journey to the centre of the cell (JTCC)∗: a 3D VR experience derived from migratory breast cancer cell image data

McGhee, John, Bailey, Benjamin, Parton, Robert G., Ariotti, Nicholas and Johnston, Angus (2016). Journey to the centre of the cell (JTCC)∗: a 3D VR experience derived from migratory breast cancer cell image data. 2016 SIGGRAPH ASIA VR Showcase, SA 2016, Macau, China, 5 - 8 December 2016. New York, NY, United States: Association for Computing Machinery. doi: 10.1145/2996376.2996385

Role of anionic phospholipids for caveolae formation and function.

Hirama, T., Das, R., Parton, R. G., Fairn, G. D. and Grinstein, S. (2015). Role of anionic phospholipids for caveolae formation and function.. BETHESDA: AMER SOC CELL BIOLOGY.

Molecular organization and membrane interactions of the cavin coat complex

Collins, B., Kovtun, O., Tillu, V. and Parton, R. (2014). Molecular organization and membrane interactions of the cavin coat complex. FEBS EMBO 2014 Conference, Paris France, Aug 30-Sep 04, 2014. HOBOKEN: WILEY-BLACKWELL.

Structural dissection of architecture of caveolar protein coat

Kovtun, O., Tillu, V., Jung, W., Leneva, N., Ariotti, N., Alexandrov, K., Parton, R. and Collins, B. (2014). Structural dissection of architecture of caveolar protein coat. FEBS EMBO 2014 Conference, Paris, France, 30 August - 4 September, 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

1588P - Caveolin-1 Modulates Vegf-A and Vegf-C Expression and Enhances Prostate Cancer Lymphangiogenesis Potential

Nassar, Z.D., Francois, M., Parton, R.G. and Parat, M.O. (2014). 1588P - Caveolin-1 Modulates Vegf-A and Vegf-C Expression and Enhances Prostate Cancer Lymphangiogenesis Potential. 39th ESMO Congress (ESMO 2014), Madrid, Spain, 26 – 30 September 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdu358.19

Disruption of cortical tension patterning drives the outgrowth of oncogenic cells

Wu, S., Gomez, G. A., Michael, M., Verma, S., Cox, H., Lefevre, J. G., Parton, R. G., Hamilton, N. A. and Yap, A. S. (2014). Disruption of cortical tension patterning drives the outgrowth of oncogenic cells. EACR-23: 23rd Biennial Congress of the European Association for Cancer Research, Munich, Germany, 5-8 July 2014. Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(14)50251-1

Cavin regulates caveolar endocytosis by forming "crescents" that girdle caveolae, stabilizes them in relatively flat conformations, and links them to cortical actin filaments

Morone, N., Parton, R. and Heuser, J. (2012). Cavin regulates caveolar endocytosis by forming "crescents" that girdle caveolae, stabilizes them in relatively flat conformations, and links them to cortical actin filaments. BETHESDA: AMER SOC CELL BIOLOGY.

Cavins and Caveolins independently regulate the CLIC/GEEC endocytic pathway

Chaudhary, N., Howes, M. and Parton, R. G. (2012). Cavins and Caveolins independently regulate the CLIC/GEEC endocytic pathway. BETHESDA: AMER SOC CELL BIOLOGY.

New insights into the domains and dynamics of the plasma membrane

Parton, Robert G. (2011). New insights into the domains and dynamics of the plasma membrane. 38th Annual Meeting of the Society-for-Cutaneous-Ultrastructure-Research, Brisbane Australia, 30-31 May 2011. Oxford,: Wiley-Blackwell Publishing.

alpha-Actinin-3 regulates muscle glycogen phosphorylase: A potential mechanism for the metabolic consequences of the common human null allele of ACTN3

Quinlan, Kgr, Seto, JT, Turner, N, Floetenmeyer, M, Macarthur, DG, Raftery, JM, Yang, N, Parton, RG, Cooney, GJ and North, KN (2009). alpha-Actinin-3 regulates muscle glycogen phosphorylase: A potential mechanism for the metabolic consequences of the common human null allele of ACTN3. 14th International Congress of the World-Muscle-Society, Geneva Switzerland, Sep 09-12, 2009. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.nmd.2009.06.011

The identification of novel CSF-1 target genes in human macrophages

Irvine, Katharine M., Andrews, Melanie R., Fernandez, Manuel A., Parton, Robert G., Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Hume, David A. and Sweet, M. J. (2008). The identification of novel CSF-1 target genes in human macrophages. 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal Canada, Oct 12-16, 2008. LONDON: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD. doi: 10.1016/j.cyto.2008.07.078

Lipid droplet fusion is regulated by protein kinase A activity in both adipocyte and non-adipocyte cell lines

Murphy, Samantha, Martin, Sally and Parton, Robert G. (2008). Lipid droplet fusion is regulated by protein kinase A activity in both adipocyte and non-adipocyte cell lines. 49th International Conference on the Bioscience of Lipids, Maastricht, The Netherlands, 26-30 August 2008. Ireland: Elsevier Ireland Ltd. doi: 10.1016/j.chemphyslip.2008.05.095

Hybrid organic-inorganic nanoparticles: controlled incorporation of gold nanoparticles into virus-like particles and application in surface-enhanced Raman spectroscopy.

Niebert, Marcus, Riches, James, Howes, Mark, Ferguson, Charles, Parton, Robert G., Middelberg, Anton P. J., Rintoul, Llew and Fredericks, Peter M. (2007). Hybrid organic-inorganic nanoparticles: controlled incorporation of gold nanoparticles into virus-like particles and application in surface-enhanced Raman spectroscopy.. SPIE International Symposium on Smart Materials, Nano- and Micro-Smart System, Adelaide, Australia, December 11-13, 2006. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.695578

Cholesterol is good, just ask the flaviviruses

Mackenzie, J M, Khromykh, A and Parton, R G (2006). Cholesterol is good, just ask the flaviviruses. Annual Scientific Meeting & Exhibition - Aust Society for Micry, Gold Coast, 2-6 July, 2006.

Inhibition of interferon signaling in flavivirus-infected cells is associated with virus-induced cholesterol re-distribution

Mackenzie, J M, Liu, W, Parton, R G and Khromykh, A (2006). Inhibition of interferon signaling in flavivirus-infected cells is associated with virus-induced cholesterol re-distribution. 13th International Mtg on Hepatitis C Virus & Related Viruses, Cairns, 27-31 Aug, 2006.

Ras Plasma Membrane Signaling Platforms

Plowman, S., Harding, A., Tinhai, T., Parton, R. G. and Hancock, J. F. (2006). Ras Plasma Membrane Signaling Platforms. Croucher Advanced Study Institute (ASI):Signaling in Cell Growth and Differentiation, Hong Kong, 16-20 January, 2006. Basel: Karger. doi: 10.1159/000094386

A bigmac a day keeps the flavivirus away

Mackenzie, J. M., Khromykh, A. and Parton, R. G. (2005). A bigmac a day keeps the flavivirus away. 3rd Australian Virology Group Meeting, Phillip Is, 9-12 Dec, 2005.

West Nile manipulates cholesterol balance affecting the lipid raft formation and function

Mackenzie, J. M., Khromykh, A. and Parton, R. G. (2005). West Nile manipulates cholesterol balance affecting the lipid raft formation and function. 24th Annual Meeting of American Society for Virology, Pennsylvania, 18-22 June, 2005.

Expression of CYP27A1 and caveolin-1 enhances cholesterol efflux

Sviridov, D, Escher, G, Fu, Y, Parton, R, Croft, K and Krozowski, Z (2003). Expression of CYP27A1 and caveolin-1 enhances cholesterol efflux. 13th International Symposium on Atherosclerosis, Kyoto Japan, Sep 28-Oct 02, 2003. CLARE: ELSEVIER SCI IRELAND LTD. doi: 10.1016/S1567-5688(03)90595-2

A role for cholesterol-dependent membrane microdomains in E-cadherin adhesion

McCormack, AJ, Pol, A, Parton, RG and Yap, AS (2001). A role for cholesterol-dependent membrane microdomains in E-cadherin adhesion. BETHESDA: AMER SOC CELL BIOLOGY.

Caveolin dominant-negative mutants perturb Ras signalling through cholesterol-rich raft domains

Parton, RG, Pol, A, Roy, S, Luetterforst, R and Hancock, JH (2001). Caveolin dominant-negative mutants perturb Ras signalling through cholesterol-rich raft domains. OXFORD: BLACKWELL SCIENCE LTD.

Insights into the regulation of hedgehog signalling from subcellular localisation studies

Wicking, C. A., Evans, T., Wainwright, B. and Parton, R. (2001). Insights into the regulation of hedgehog signalling from subcellular localisation studies. -, -, -. Chicago, IL United States: University of Chicago Press.

Interaction of antiphospholipid antibodies with late endosomes of human endothelial cells.

de Rochemonteix, BG, Kobayashi, T, Rosnoblet, C, Lindsay, M, Parton, RG, Reber, G, de Maistre, E, Wahl, D, Kruithof, EKO, Gruenberg, J and de Moerloose, P (1999). Interaction of antiphospholipid antibodies with late endosomes of human endothelial cells.. STUTTGART: F K SCHATTAUER VERLAG GMBH.

Developmental regulation of microtubule organisation in oligodendrocytes

Gordon, D., Smith, R. W., Parton, R. G. and Kidd, G. J. (1999). Developmental regulation of microtubule organisation in oligodendrocytes. 39th Annual Meeting of the American Society for Cell Biology, Washington Convention Centre, Washington D.C., 11th - 15th December, 1999. Bethesda, Maryland: American Society for Cell Biology.

The copper transporting p-type ATPase of Menkes disease

Camakaris, J., Voskoboinik, I., Mercer, J., Lane, C., Parton, R. G., Petris, M. and Strausak, D. (1999). The copper transporting p-type ATPase of Menkes disease. International Conference on Biological Inorganic Chemistry, Minneapolis, Minnesota, July 11-16. New York: Elsevier Science.

EM localisation of the MNK copper transporting P-type ATPase

Lane, C, Parton, RG, Mercer, JFB and Camakaris, J (1998). EM localisation of the MNK copper transporting P-type ATPase. BETHESDA: AMER SOC CELL BIOLOGY.

Regulation of caveolin and caveolae by cholesterol in MDCK cells

Stanley, KK, Sleer, LS, Parton, RG and Hailstones, D (1997). Regulation of caveolin and caveolae by cholesterol in MDCK cells. BETHESDA: AMER SOC CELL BIOLOGY.

Caveolin-3 associates with developing T-tubules during muscle differentiation: Evidence for a role for caveolins in plasma membrane morphogenesis.

Parton, RG, Way, M and Stang, E (1996). Caveolin-3 associates with developing T-tubules during muscle differentiation: Evidence for a role for caveolins in plasma membrane morphogenesis.. BETHESDA: AMER SOC CELL BIOLOGY.

Role of VIP21-caveolin oligomeric complex in protein and lipid sorting in MDCK cells

Ikonen, E, Scheiffele, P, Fra, AM, Parton, RG and Simons, K (1996). Role of VIP21-caveolin oligomeric complex in protein and lipid sorting in MDCK cells. BETHESDA: AMER SOC CELL BIOLOGY.

And still they are moving... Dynamic properties of caveolae

Kurzchalia, Teymuras V. and Parton, Robert G. (1996). And still they are moving... Dynamic properties of caveolae. Elsevier B.V.. doi: 10.1016/0014-5793(96)00585-6

CHARACTERIZATION OF PHAGOCYTIC COMPARTMENTS IN J774 MACROPHAGES

DESJARDINS, M, HUBER, L, PARTON, R and GRIFFITHS, G (1993). CHARACTERIZATION OF PHAGOCYTIC COMPARTMENTS IN J774 MACROPHAGES. NEW YORK: WILEY-LISS.

LOCALIZATION OF VIP-21, AN INTEGRAL MEMBRANE-PROTEIN OF TGN-DERIVED EXOCYTIC VESICLES, TO CAVEOLAE

PARTON, RG, DUPREE, P, KURZCHALIA, TV and SIMONS, K (1993). LOCALIZATION OF VIP-21, AN INTEGRAL MEMBRANE-PROTEIN OF TGN-DERIVED EXOCYTIC VESICLES, TO CAVEOLAE. NEW YORK: WILEY-LISS.

SORTING OF SURFACE-PROTEINS IN THE TRANS-GOLGI NETWORK OF EPITHELIAL-CELLS AND NEURONS

SIMONS, K, DOTTI, C, DUPREE, P, HUBER, L, KURZCHALIA, T and PARTON, R (1993). SORTING OF SURFACE-PROTEINS IN THE TRANS-GOLGI NETWORK OF EPITHELIAL-CELLS AND NEURONS. NEW YORK: WILEY-LISS.

SORTING OF SURFACE-PROTEINS IN THE TRANS-GOLGI NETWORK OF MDCK CELLS

SIMONS, K, DUPREE, P, HUBER, L, KURZCHALIA, T and PARTON, R (1993). SORTING OF SURFACE-PROTEINS IN THE TRANS-GOLGI NETWORK OF MDCK CELLS. NEW YORK: WILEY-LISS.

THE EXOCYTIC AND ENDOCYTIC PATHWAYS OF POLARIZED NEURONS

DOTTI, CG, PARTON, R, KOBAYASHI, T, HUBER, L, DUPREE, P, STORRIE, B and SIMONS, K (1993). THE EXOCYTIC AND ENDOCYTIC PATHWAYS OF POLARIZED NEURONS. NEW YORK: WILEY-LISS.

VIP-21, AN INTEGRAL COMPONENT OF TRANS-GOLGI-NETWORK-DERIVED TRANSPORT VESICLES

DUPREE, P, PARTON, R, KURZCHALIA, TV and SIMONS, K (1992). VIP-21, AN INTEGRAL COMPONENT OF TRANS-GOLGI-NETWORK-DERIVED TRANSPORT VESICLES. BETHESDA: AMER SOC CELL BIOLOGY.

THE POLARIZED ORGANIZATION OF THE ENDOCYTIC PATHWAYS IN MDCK EPITHELIAL-CELLS

PARTON, RG, BOMSEL, M, GRIFFITHS, G, GRUENBERG, J and SIMONS, K (1991). THE POLARIZED ORGANIZATION OF THE ENDOCYTIC PATHWAYS IN MDCK EPITHELIAL-CELLS. NEW YORK: HISTOCHEMICAL SOC INC.

ACIDIFICATION OF MDCK CELLS INDUCES A REDISTRIBUTION OF LATE ENDOSOMAL COMPARTMENTS

PRYDZ, K, BACALLAO, R, PARTON, R and SIMONS, K (1990). ACIDIFICATION OF MDCK CELLS INDUCES A REDISTRIBUTION OF LATE ENDOSOMAL COMPARTMENTS. CAMBRIDGE: BLACKWELL SCIENCE INC.

A role for caveolar proteins in regulation of the circadian clock

Fonseka, Sachini, Weger, Benjamin D., Weger, Meltem, Martel, Nick, Hall, Thomas Edward, Varasteh Moradi, Shayli, Gabriel, Christian H., Kramer, Achim, Ferguson, Charles, Fernández-Rojo, Manuel A., Alexandrov, Kirill, Rawashdeh, Oliver, McMahon, Kerrie-Ann, Gachon, Frederic and Parton, Robert G. (2022). A role for caveolar proteins in regulation of the circadian clock.

Caveolins

Parton, R. G. (2002). Caveolins.