Professor Jennifer Stow

NHMRC Leadership Fellow

Institute for Molecular Bioscience

j.stow@imb.uq.edu.au
+61 7 334 62034
+61 7 334 62159

Overview

Professor Jennifer Stow is a molecular cell biologist, an NHMRC Leadership Fellow and head of the Protein Trafficking and Inflammation research laboratory in The University of Queensland’s Institute of Molecular Bioscience (IMB). Her previous leadership appointments include as Division Head and Deputy Director (Research) at IMB (12 years) and she currently serves on national and international advisory boards, editorial boards and steering committees, and as an elected Associate Member of the European Molecular Biology Organisation (EMBO).

Jenny Stow received her undergraduate and PhD qualifications at Melbourne’s Monash University before undertaking postdoctoral training in the Department of Cell Biology at Yale University School of Medicine, USA. With training as a microscopist in kidney research, she gained further experience at Yale as a postdoc in the lab of eminent cell biologist and microscopist, Dr Marilyn Farquhar, where protein trafficking was both a theme and a passion. Jenny then took up her first faculty appointment as an Assistant Professor in the Renal Unit at Massachusetts General Hospital (MGH) and Harvard Medical School in Boston USA, where her research uncovered new roles for a class of enzymes, GTPases, in regulating trafficking within cells. At MGH her research also formed part of a highly successful NIH Renal Cell Biology Program. In late 1994, Jenny moved her research lab back to Australia, to The University of Queensland, in late 1994 as a Wellcome Trust International Medical Research Fellow. As part of IMB since, the Stow lab has continued a focus on protein trafficking, including pioneering live-cell imaging, to spearhead their work on trafficking in inflammation, cancer and chronic disease. Major discoveries include identifying new proteins and pathways for recycling adhesion proteins in epithelial cells, inflammatory cytokine secretion in macrophages and immune signalling through Toll-like receptors in inflammation and infection. Small GTPases of the Rab family, signalling adaptors and kinases feature among the molecules studied in the Stow lab for their functional roles and their potential as drug targets in inflammation and cancer. A keen focus is to understand the role of the fluid uptake pathway, macropinocytosis, in controlling inflammation, cancer and mucosal absorption.

Professor Stow has been awarded multiple career fellowships including from American Heart Association, Wellcome Trust and NHMRC. She has published >200 papers, cited over 15,500 times and she is the recipient of awards and honours, most recently including the 2019 President's Medal from the Australia and New Zealand Society for Cell and Developmental Biology. She is also academic head of IMB Microscopy, a world-class fluorescence microscopy and image analysis facility. Her research is funded by a variety of agencies and industry partnerships, in addition to NHMRC and ARC, including through the ARC Centre of Excellence in Quantum Biotechnology, QUBIC. The Stow lab work with national and international collaborators and welcome students and postdoctoral trainees to participate in their research. We value having a diverse, inclusive and supportive culture for research and celebrate the many diverse and wonderful successes of Stow lab alumni.

Research Interests

Controlling Inflammation: Receptor Signalling and Cytokine Secretion.
Immune cells like macrophages are activated by contact with pathogens and other stimuli, triggering protective immune and inflammatory responses. Signalling pathways generated by macrophage Toll-like receptors (TLRs) elicit the synthesis and secretion of pro- and anti-inflammatory cytokines. These cytokines instruct other cells to mount either anti-microbial attack responses, followed by tissue repair responses, that over time, control and suppress inflammation. Disrupting the finely tuned TLR signalling pathways and release of cytokines leads to the inflammatory tissue damage that accompanies many chronic diseases. Our research investigates the roles of TLR signalling regulators, including coreceptors, signalling adaptors, lipid kinases and GTPases that help to bias and control cytokine programming. While current therapies target the cytokines themselves, our research is generating strategies to target additional regulatory molecules to control inflammation in disease.
Cellular Pathways to and from the Cell Surface.
Cells have intimate contact with their tissue environments and each other through many cell surface projections and trafficking pathways that move proteins, membranes and other matter into and out of cells. Live cell imaging and microscopy reveal these behaviours at molecular, cellular and tissue levels. Our research examines the surface features (ruffles, filopodia, cilia) and cellular pathways (macropinocytosis, secretory and recycling pathways) in macrophages, other immune cells, epithelial cells and cancer cells that give each of them specialised functions. As revealed by our research, many of these pathways are governed by small GTPases of the Rab family and their effector molecules. Understanding these pathways is important in disease, for instance, immunity, inflammation and cancer metastasis are all dependent on the Rab-mediated macropinocytosis or cell drinking pathways we investigate.

Research Impacts

Understanding how cells and molecules within our bodies function is essential for understanding and addressing diseases and other factors that affect our biology, such as genetics, environment, drugs and bugs. Cells contain remarkably complex pathways for trafficking, or moving proteins around, and for the receptor signalling that controls cell responses. Many of these pathways are affected in disease and are also the targets for drugs we use to treat disease. Insights gained from our research generate a fundamental understanding of cell biology as a necessary framework for developing new treatment strategies. Poorly controlled inflammation is a pervasive disease process underlying many chronic diseases and our research on immune cells is uncovering how inflammation is normally controlled within cells. This information is instructive for devising strategies and identifying drugs that are likely to control inflammation in different chronic diseases and in cancer.

Our work takes advantage of the cutting-edge rsearch facilities in IMB at The University of Queensland, and we collaborate with many valued colleagues throughout Australia and around the world. Technologically, it is a very exciting time for biological and biomedical research, with the rapid development of new types of microscopy, laser imaging, big-image data computing, artificial intelligence and virtual reality capabilities for visualising and analysing living cells and tissues. Our research is part of national and global efforts to refine and apply the latest imaging and big data technologies to resolve structures and processes in normal cells and in cells affected by disease.

Qualifications

Doctor of Philosophy, Monash University
Bachelor of Science (Honours), Monash University

Publications

Journal Article: TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages

Curson, James E. B., Liu, Liping, Luo, Lin, Muusse, Timothy W., Lucas, Richard M., Gunther, Kimberley S., Vajjhala, Parimala R., Abrol, Rishika, Jones, Alun, Kapetanovic, Ronan, Stacey, Katryn J., Stow, Jennifer L. and Sweet, Matthew J. (2023). TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages. European Journal of Immunology, 53 (7) e2250056, e2250056. doi: 10.1002/eji.202250056
Journal Article: SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

Luo, Lin, Bokil, Nilesh J., Wall, Adam A., Kapetanovic, Ronan, Lansdaal, Natalie M., Marceline, Faustine, Burgess, Belinda J., Tong, Samuel J., Guo, Zhong, Alexandrov, Kirill, Ross, Ian L., Hibbs, Margaret L., Stow, Jennifer L. and Sweet, Matthew J. (2017). SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nature Communications, 8 (1) 14133, 14133. doi: 10.1038/ncomms14133
Journal Article: A role for the phagosome in cytokine secretion

Murray, R. Z., Kay, J. G., Sangermani, D. G. and Stow, J. L. (2005). A role for the phagosome in cytokine secretion. Science, 310 (5753), 1492-1495. doi: 10.1126/science.1120225

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Grants

ARC Centre of Excellence in Quantum Biotechnology

(2023–2029) ARC Centres of Excellence
Cell fluid interaction: inside and outside cells

(2023–2026) ARC Discovery Projects
Gut Absorption of Constrained Peptides for Local and Systemic Targeting

(2023–2026) ARC Linkage Projects

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Supervision

Barrier functions of the intestinal epithelium.

Doctor Philosophy
Cell death, inflammation, and macrophages in cardiac ischemia and metabolic disease

Doctor Philosophy
Gut inflammation: model systems and the development of anti-inflammatory peptide drugs.

Doctor Philosophy

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Publications

Featured Publications

SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

Luo, Lin, Bokil, Nilesh J., Wall, Adam A., Kapetanovic, Ronan, Lansdaal, Natalie M., Marceline, Faustine, Burgess, Belinda J., Tong, Samuel J., Guo, Zhong, Alexandrov, Kirill, Ross, Ian L., Hibbs, Margaret L., Stow, Jennifer L. and Sweet, Matthew J. (2017). SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nature Communications, 8 (1) 14133, 14133. doi: 10.1038/ncomms14133
A role for the phagosome in cytokine secretion

Murray, R. Z., Kay, J. G., Sangermani, D. G. and Stow, J. L. (2005). A role for the phagosome in cytokine secretion. Science, 310 (5753), 1492-1495. doi: 10.1126/science.1120225

Book Chapter

Post-Golgi Transport - Cargo, Carriers, and Pathways

Stow, J.L. and Murray, R.Z. (2023). Post-Golgi Transport - Cargo, Carriers, and Pathways. Encyclopedia of Cell Biology. (pp. 507-515) Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-821618-7.20035-7
Detecting Endogenous Rab8 Activation

Tong, Samuel J., Lucas, Richard M., Xiao, Zhijian, Luo, Lin and Stow, Jennifer L. (2021). Detecting Endogenous Rab8 Activation. Rab GTPases: Methods and Protocols. (pp. 45-56) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-1346-7_4
Image-based analysis of phagocytosis: measuring engulfment and internalization

Condon, Nicholas D., Wall, Adam A., Yeo, Jeremy C., Hamilton, Nicholas A. and Stow, Jennifer L. (2017). Image-based analysis of phagocytosis: measuring engulfment and internalization. In Roberto Botelho (Ed.), Phagocytosis and phagosomes: methods and protocols (pp. 201-214) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-6581-6_13
Post-golgi transport - cargo, carriers, and pathways

Stow, J. L. and Murray, R. Z. (2016). Post-golgi transport - cargo, carriers, and pathways. Encyclopedia of cell biology. (pp. 363-370) edited by Ralph A. Bradshaw and Philip D. Stahl. Waltham, MA, United States: Academic Press/Elsevier. doi: 10.1016/B978-0-12-394447-4.20035-7
Rab23

Gual-Soler, Marga, Taguchi, Tomohiko, Stow, Jennifer L. and Wicking, Carol (2012). Rab23. Encyclopedia of signalling molecules. (pp. 1532-1536) edited by Sangdun Choi. New York, United States: Springer. doi: 10.1007/978-1-4419-0461-4
Expression and localization of proteins in mammalian cells

Stow, J. L. and Teasdale, R. D. (2005). Expression and localization of proteins in mammalian cells. Encyclopedia of Genetics, Genomics, Proteomics and Bioformatics. (pp. ---) edited by P S E Little and J S E Quackenbush. London, England: John Wiley & Sons. doi: 10.1002/047001153x.g208202

Journal Article

TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages

Curson, James E. B., Liu, Liping, Luo, Lin, Muusse, Timothy W., Lucas, Richard M., Gunther, Kimberley S., Vajjhala, Parimala R., Abrol, Rishika, Jones, Alun, Kapetanovic, Ronan, Stacey, Katryn J., Stow, Jennifer L. and Sweet, Matthew J. (2023). TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages. European Journal of Immunology, 53 (7) e2250056, e2250056. doi: 10.1002/eji.202250056
Macrophage Nrf 2 the rescue

Stow, Jennifer L. and Sweet, Matthew J. (2023). Macrophage Nrf 2 the rescue. Journal of Cell Biology, 222 (6) e202305036. doi: 10.1083/jcb.202305036
HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages

Das Gupta, Kaustav, Ramnath, Divya, von Pein, Jessica B., Curson, James E. B., Wang, Yizhuo, Abrol, Rishika, Kakkanat, Asha, Moradi, Shayli Varasteh, Gunther, Kimberley S., Murthy, Ambika M. V., Stocks, Claudia J., Kapetanovic, Ronan, Reid, Robert C., Iyer, Abishek, Ilka, Zoe C., Nauseef, William M., Plan, Manuel, Luo, Lin, Stow, Jennifer L., Schroder, Kate, Karunakaran, Denuja, Alexandrov, Kirill, Shakespear, Melanie R., Schembri, Mark A., Fairlie, David P. and Sweet, Matthew J. (2023). HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages. Proceedings of the National Academy of Sciences, 120 (4) e2212813120, 1-12. doi: 10.1073/pnas.2212813120
ERK1/2 in immune signalling

Lucas, Richard M., Luo, Lin and Stow, Jennifer L. (2022). ERK1/2 in immune signalling. Biochemical Society Transactions, 50 (5), 1-12. doi: 10.1042/bst20220271
Rotational optical tweezers for active microrheometry within living cells

Watson, Mark L., Brown, Darren L., Stilgoe, Alexander B., Stow, Jennifer L. and Rubinsztein-Dunlop, Halina (2022). Rotational optical tweezers for active microrheometry within living cells. Optica, 9 (9), 1066-1072. doi: 10.1364/optica.468713
The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs

Liu, Liping, Lucas, Richard M., Nanson, Jeffrey D., Li, Yan, Whitfield, Jason, Curson, James E. B., Tuladhar, Neeraj, Alexandrov, Kirill, Mobli, Mehdi, Sweet, Matthew J., Kobe, Bostjan, Stow, Jennifer and Luo, Lin (2022). The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs. Journal of Biological Chemistry, 298 (5) 101857, 101857. doi: 10.1016/j.jbc.2022.101857
An alternative downstream translation start site in the non‐TIR adaptor Scimp enables selective amplification of CpG DNA responses in mouse macrophages

Curson, James E.B., Luo, Lin, Liu, Liping, Burgess, Belinda J., Bokil, Nilesh J., Wall, Adam A, Brdicka, Tomas, Kapetanovic, Ronan, Stow, Jennifer L and Sweet, Matthew J (2022). An alternative downstream translation start site in the non‐TIR adaptor Scimp enables selective amplification of CpG DNA responses in mouse macrophages. Immunology and Cell Biology, 100 (4), 267-284. doi: 10.1111/imcb.12540
Host glycocalyx captures HIV proximal to the cell surface via oligomannose-GlcNAc glycan-glycan interactions to support viral entry

Spillings, Belinda L., Day, Christopher J., Garcia-Minambres, Albert, Aggarwal, Anupriya, Condon, Nicholas D., Haselhorst, Thomas, Purcell, Damian F.J., Turville, Stuart G., Stow, Jennifer L., Jennings, Michael P. and Mak, Johnson (2022). Host glycocalyx captures HIV proximal to the cell surface via oligomannose-GlcNAc glycan-glycan interactions to support viral entry. Cell Reports, 38 (5) 110296, 110296. doi: 10.1016/j.celrep.2022.110296
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages

Lucas, Richard M., Liu, Liping, Curson, James E. B., Koh, Yvette W. H., Tuladhar, Neeraj, Condon, Nicholas D., Das Gupta, Kaustav, Burgener, Sabrina S., Schroder, Kate, Ingley, Evan, Sweet, Matthew J., Stow, Jennifer L. and Luo, Lin (2021). SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages. Cell Reports, 36 (10) 109662, 1-20. doi: 10.1016/j.celrep.2021.109662
LLAMA: a robust and scalable machine learning pipeline for analysis of large scale 4D microscopy data: analysis of cell ruffles and filopodia

Lefevre, James G., Koh, Yvette W. H., Wall, Adam A., Condon, Nicholas D., Stow, Jennifer L. and Hamilton, Nicholas A. (2021). LLAMA: a robust and scalable machine learning pipeline for analysis of large scale 4D microscopy data: analysis of cell ruffles and filopodia. BMC Bioinformatics, 22 (1) 410, 1-26. doi: 10.1186/s12859-021-04324-z
Live fluorescence, inverse imaging of cell ruffling, and macropinocytosis

Koh, Yvette W. H., Hung, Yu, Tuladhar, Neeraj, Xiao, Zhijian, Brown, Darren L., Condon, Nicholas D. and Stow, Jennifer L. (2021). Live fluorescence, inverse imaging of cell ruffling, and macropinocytosis. Journal of Visualized Experiments (174). doi: 10.3791/62870
A Leep1 into migration and macropinocytosis

Koh, Yvette W.H. and Stow, Jennifer L. (2021). A Leep1 into migration and macropinocytosis. Journal of Cell Biology, 220 (7) e202105141, 1-2. doi: 10.1083/jcb.202105141
Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection

Domínguez Cadena, Leslie C., Schultz, Thomas E., Zamoshnikova, Alina, Donovan, Meg L., Mathmann, Carmen D., Yu, Chien-Hsiung, Mori, Giorgia, Stow, Jennifer L and Blumenthal, Antje (2021). Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection. Immunology and Cell Biology, 99 (10), 1067-1076. doi: 10.1111/imcb.12503
Ciliopathies and the kidney: a review

McConnachie, Dominique J., Stow, Jennifer L. and Mallett, Andrew J. (2020). Ciliopathies and the kidney: a review. American Journal of Kidney Diseases, 77 (3), 410-419. doi: 10.1053/j.ajkd.2020.08.012
Neurotoxic peptides from the venom of the giant Australian stinging tree

Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828
Editorial overview: Membrane traffic in the time of COVID-19

Brodsky, Frances M. and Stow, Jennifer L. (2020). Editorial overview: Membrane traffic in the time of COVID-19. Current Opinion in Cell Biology, 65, iii-v. doi: 10.1016/j.ceb.2020.09.003
High‐speed squeeze: light‐sheet imaging of zebrafish neutrophils

Stow, Jennifer L. and Condon, Nicholas D. (2020). High‐speed squeeze: light‐sheet imaging of zebrafish neutrophils. Journal of Leukocyte Biology, 108 (2), 447-449. doi: 10.1002/jlb.1ce0320-082
Macropinocytosis: insights from immunology and cancer

Stow, Jennifer L., Hung, Yu and Wall, Adam A. (2020). Macropinocytosis: insights from immunology and cancer. Current Opinion in Cell Biology, 65, 131-140. doi: 10.1016/j.ceb.2020.06.005
Toll-like receptor 4 stimulates gene expression via Smad2 linker region phosphorylation in vascular smooth muscle cells

Afroz, Rizwana, Zhou, Ying, Little, Peter J., Xu, Suowen, Mohamed, Raafat, Stow, Jennifer and Kamato, Danielle (2020). Toll-like receptor 4 stimulates gene expression via Smad2 linker region phosphorylation in vascular smooth muscle cells. ACS Pharmacology and Translational Science, 3 (3) acsptsci.9b00113, 524-534. doi: 10.1021/acsptsci.9b00113
Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2

Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007
A life in pictures—Marilyn Gist Farquhar

Stow, Jennifer L., Saraste, Jaakko and Brown, William J. (2020). A life in pictures—Marilyn Gist Farquhar. Journal of Cell Biology, 219 (2). doi: 10.1083/jcb.202001010
Automated analysis of cell surface ruffling: ruffle quantification macro

Condon, Nicholas D., Stow, Jennifer L. and Wall, Adam A. (2020). Automated analysis of cell surface ruffling: ruffle quantification macro. Bio-Protocol, 10 (2), e3494. doi: 10.21769/BioProtoc.3494
Signalling, sorting and scaffolding adaptors for Toll-like receptors

Luo, Lin, Lucas, Richard M., Liu, Liping and Stow, Jennifer L. (2019). Signalling, sorting and scaffolding adaptors for Toll-like receptors. Journal of Cell Science, 133 (5) jcs239194, jcs239194. doi: 10.1242/jcs.239194
SCIMP is a universal Toll‐like receptor adaptor in macrophages

Luo, Lin, Curson, James E. B., Liu, Liping, Wall, Adam A., Tuladhar, Neeraj, Lucas, Richard M., Sweet, Matthew J. and Stow, Jennifer L. (2019). SCIMP is a universal Toll‐like receptor adaptor in macrophages. Journal of Leukocyte Biology, 107 (2) JLB.2MA0819-138RR, 251-262. doi: 10.1002/jlb.2ma0819-138rr
Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation

Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Gupta, Praveer K., Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2019). Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation. British Journal of Pharmacology, 176 (19) bph.14768, 3775-3790. doi: 10.1111/bph.14768
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes

Guo, Dajiang, Lui, Goldie Y. L., Lai, Siew Li, Wilmott, James S., Tikoo, Shweta, Jackett, Louise A., Quek, Camelia, Brown, Darren L., Sharp, Danae M., Kwan, Rain Y. Q., Chacon, Diego, Wong, Jason H., Beck, Dominik, van Geldermalsen, Michelle, Holst, Jeff, Thompson, John F., Mann, Graham J., Scolyer, Richard A., Stow, Jennifer L., Weninger, Wolfgang, Haass, Nikolas K. and Beaumont, Kimberley A. (2019). RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes. International Journal of Cancer, 144 (12), 3070-3085. doi: 10.1002/ijc.32064
Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling

Tong, Samuel J., Wall, Adam A., Hung, Yu, Luo, Lin and Stow, Jennifer L. (2019). Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling. Small GTPases, 12 (1), 1-17. doi: 10.1080/21541248.2019.1587278
Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes

Wall, Adam A., Condon, Nicholas D., Luo, Lin and Stow, Jennifer L. (2019). Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes. Philosophical Transactions of the Royal Society B: Biological Sciences, 374 (1765) 20180151, 20180151. doi: 10.1098/rstb.2018.0151
Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes

Kamato, Danielle, Burch, Micah, Yang, Zhou, Mohamed, Raafat, Stow, Jennifer L., Osman, Narin and Little, Peter J. (2019). Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes. Cellular Signalling, 53, 365-373. doi: 10.1016/j.cellsig.2018.11.005
Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

Kojic, Marija, Gaik, Monika, Kiska, Bence, Salerno-Kochan, Anna, Hunt, Sarah, Tedoldi, Angelo, Mureev, Sergey, Jones, Alun, Whittle, Belinda, Genovesi, Laura A., Adolphe, Christelle, Brown, Darren L., Stow, Jennifer L., Alexandrov, Kirill, Sah, Pankaj, Glatt, Sebastian and Wainwright, Brandon J. (2018). Elongator mutation in mice induces neurodegeneration and ataxia-like behavior. Nature Communications, 9 (1) 3195, 3195. doi: 10.1038/s41467-018-05765-6
TLR crosstalk activates LRP1 to recruit Rab8a and PI3Kγ for suppression of inflammatory responses

Luo, Lin, Wall, Adam A., Tong, Samuel J., Hung, Yu, Xiao, Zhijian, Tarique, Abdullah A., Sly, Peter D., Fantino, Emmanuelle, Marzolo, María-Paz and Stow, Jennifer L. (2018). TLR crosstalk activates LRP1 to recruit Rab8a and PI3Kγ for suppression of inflammatory responses. Cell Reports, 24 (11), 3033-3044. doi: 10.1016/j.celrep.2018.08.028
Macropinosome formation by tent pole ruffling in macrophages

Condon, Nicholas D., Heddleston, John M., Chew, Teng-Leong, Luo, Lin, McPherson, Peter S., Ioannou, Maria S., Hodgson, Louis, Stow, Jennifer L. and Wall, Adam A. (2018). Macropinosome formation by tent pole ruffling in macrophages. The Journal of Cell Biology, 217 (11), 3873-3885. doi: 10.1083/jcb.201804137
Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion

Monteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2018). Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion. Cell Reports, 24 (6), 1425-1433. doi: 10.1016/j.celrep.2018.07.027
Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes

Ramnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14). doi: 10.1172/jci.insight.120274
pTRAPs: Transmembrane adaptors in innate immune signaling

Curson, James E. B., Luo, Lin, Sweet, Matthew J. and Stow, Jennifer L. (2018). pTRAPs: Transmembrane adaptors in innate immune signaling. Journal of Leukocyte Biology, 103 (6), 1011-1019. doi: 10.1002/JLB.2RI1117-474R
Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL

Schuelein, Ralf, Spencer, Hugh, Dagley, Laura F, Li, Peng Fei, Luo, Lin, Stow, Jennifer L, Abraham, Gilu, Naderer, Thomas, Gomez-Valero, Laura, Buchrieser, Carmen, Sugimoto, Chihiro, Yamagishi, Junya, Webb, Andrew I, Pasricha, Shivani and Hartland, Elizabeth L (2018). Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL. Cellular Microbiology, 20 (9) e12852, e12852. doi: 10.1111/cmi.12852
Differential expression of genes and receptors in monocytes from patients with cystic fibrosis

Tarique, Abdullah A., Sly, Peter D., Cardenas, Diana G., Luo, Lin, Stow, Jennifer L., Bell, Scott C., Wainwright, Claire E. and Fantino, Emmanuelle (2018). Differential expression of genes and receptors in monocytes from patients with cystic fibrosis. Journal of Cystic Fibrosis, 18 (3), 342-348. doi: 10.1016/j.jcf.2018.07.012
Salmonella effector SopD2 interferes with Rab34 function

Teo, Wei Xuan, Yang, Zhe, Kerr, Markus Charles, Luo, Lin, Guo, Zhong, Alexandrov, Kirill, Stow, Jenny Lea and Teasdale, Rohan David (2017). Salmonella effector SopD2 interferes with Rab34 function. Cell Biology International, 41 (4), 433-446. doi: 10.1002/cbin.10739
Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP

Luo, Lin, Tong, Samuel J., Wall, Adam A., Khromykh, Tatiana, Sweet, Matthew J. and Stow, Jennifer L. (2017). Development of SH2 probes and pull-down assays to detect pathogen-induced, site-specific tyrosine phosphorylation of the TLR adaptor SCIMP. Immunology and Cell Biology, 95 (6), 564-570. doi: 10.1038/icb.2017.10
Small GTPase Rab8a-recruited phosphatidylinositol 3-kinase γ regulates signaling and cytokine outputs from endosomal toll-like receptors

Wall, Adam A., Luo, Lin, Hung, Yu, Tong, Samuel J., Condon, Nicholas D., Blumenthal, Antje, Sweet, Matthew J. and Stow, Jennifer L. (2017). Small GTPase Rab8a-recruited phosphatidylinositol 3-kinase γ regulates signaling and cytokine outputs from endosomal toll-like receptors. Journal of Biological Chemistry, 292 (11), 4411-4422. doi: 10.1074/jbc.M116.766337
SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

Luo, Lin, Bokil, Nilesh J., Wall, Adam A., Kapetanovic, Ronan, Lansdaal, Natalie M., Marceline, Faustine, Burgess, Belinda J., Tong, Samuel J., Guo, Zhong, Alexandrov, Kirill, Ross, Ian L., Hibbs, Margaret L., Stow, Jennifer L. and Sweet, Matthew J. (2017). SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nature Communications, 8 (1) 14133, 14133. doi: 10.1038/ncomms14133
Distinct roles for APPL1 and APPL2 in regulating toll-like receptor 4 signaling in macrophages

Yeo, Jeremy C., Wall, Adam A., Luo, Lin, Condon, Nicholas D. and Stow, Jennifer L. (2016). Distinct roles for APPL1 and APPL2 in regulating toll-like receptor 4 signaling in macrophages. Traffic, 17 (9), 1014-1026. doi: 10.1111/tra.12415
Small GTPases in trafficking - a family approach

Stow, Jennifer L. (2016). Small GTPases in trafficking - a family approach. Cellular Logistics, 6 (1), e1178036.1-e1178036.1. doi: 10.1080/21592799.2016.1178036
The cell surface environment for pathogen recognition and entry

Stow, Jennifer L. and Condon, Nicholas D. (2016). The cell surface environment for pathogen recognition and entry. Clinical and Translational Immunology, 5 (4) e71, e71.1-e71.7. doi: 10.1038/cti.2016.15
The binding of syndapin SH3 domain to dynamin proline-rich domain involves short and long distance elements

Luo, Lin, Xue, Jing, Kwan, Ann, Gamsjaeger, Roland, Wielens, Jerome, von Kleist, Lisa, Cubeddu, Liza, Guo, Zhong, Stow, Jennifer L., Parker, Michael W., Mackay, Joel P. and Robinson, Phillip J. (2016). The binding of syndapin SH3 domain to dynamin proline-rich domain involves short and long distance elements. Journal of Biological Chemistry, 291 (18), 9411-+. doi: 10.1074/jbc.M115.703108
The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists

Chen, Kaiwen W., Bezbradica, Jelena S., Gross, Christina J., Wall, Adam A., Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2016). The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists. European Journal of Immunology, 46 (4), 1004-1010. doi: 10.1002/eji.201545943
Sequential recruitment of Rab GTPases during early stages of phagocytosis

Yeo, Jeremy C., Wall, Adam A., Luo, Lin and Stow, Jennifer L. (2016). Sequential recruitment of Rab GTPases during early stages of phagocytosis. Cellular Logistics, 6 (1) e1140615, e1140615.1-e1140615.12. doi: 10.1080/21592799.2016.1140615
RORα and 25-hydroxycholesterol crosstalk regulates lipid droplet homeostasis in macrophages

Tuong, Zewen Kelvin, Lau, Patrick, Du, Ximing, Condon, Nicholas D., Goode, Joel M., Oh, Tae Gyu, Yeo, Jeremy C., Muscat, George E. O. and Stow, Jennifer L. (2016). RORα and 25-hydroxycholesterol crosstalk regulates lipid droplet homeostasis in macrophages. PLoS ONE, 11 (1) e0147179, e0147179. doi: 10.1371/journal.pone.0147179
The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments

Vajjhala, Parimala R., Lu, Alvin, Brown, Darren L., Pang, Siew Wai, Sagulenko, Vitaliya, Sester, David P., Cridland, Simon O., Hill, Justine M., Schroder, Kate, Stow, Jennifer L., Wu, Hao and Stacey, Katryn J. (2015). The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments. Journal of Biological Chemistry, 290 (49), 29217-29230. doi: 10.1074/jbc.M115.687731
RP105 engages phosphatidylinositol 3-kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection

Yu, Chien-Hsiung, Micaroni, Massimo, Puyskens, Andreas, Schultz, Thomas E., Yeo, Jeremy Changyu, Stanley, Amanda C., Lucas, Megan, Kurihara, Jade, Dobos, Karen M., Stow, Jennifer L. and Blumenthal, Antje (2015). RP105 engages phosphatidylinositol 3-kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection. Journal of Immunology, 195 (8), 3890-3900. doi: 10.4049/jimmunol.1500017
Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels

Cristofori-Armstrong, Ben, Soh, Ming S., Talwar, Sahil, Brown, Darren L., Griffin, John D. O., Dekan, Zoltan, Stow, Jennifer L., King, Glenn F., Lynch, Joseph W. and Rash, Lachlan D. (2015). Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. Scientific Reports, 5 (1) 14763, 14763.1-14763.12. doi: 10.1038/srep14763
Mechanisms of unconventional secretion of IL-1 family cytokines

Monteleone, Mercedes, Stow, Jennifer L. and Schroder, Kate (2015). Mechanisms of unconventional secretion of IL-1 family cytokines. Cytokine, 74 (2), 213-218. doi: 10.1016/j.cyto.2015.03.022
Dynamic imaging of the recycling endosomal network in macrophages

Wall, Adam A., Condon, Nicholas D., Yeo, Jeremy C., Hamilton, Nicholas A. and Stow, Jennifer L. (2015). Dynamic imaging of the recycling endosomal network in macrophages. Methods in Cell Biology, 130, 1-18. doi: 10.1016/bs.mcb.2015.04.007
Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages

Yeo, Jeremy C., Wall, Adam A., Luo, Lin and Stow, Jennifer L. (2015). Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages. Molecular Biology of the Cell, 26 (5), 952-965. doi: 10.1091/mbc.E14-10-1457
Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector

King, Nathan P., Newton, Patrice, Schuelein, Ralf, Brown, Darren L., Petru, Marketa, Zarsky, Vojtech, Dolezal, Pavel, Luo, Lin, Bugarcic, Andrea, Stanley, Amanda C., Murray, Rachael Z., Collins, Brett M., Teasdale, Rohan D., Hartland, Elizabeth L. and Stow, Jennifer L. (2015). Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector. Cellular Microbiology, 17 (6), 767-784. doi: 10.1111/cmi.12405
Ror-alpha deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white and brown adipose tissue

Lau, Patrick, Tuong, Zewen K., Wang, Shu-Ching, Fitzsimmons, Rebecca L., Goode, Joel M., Thomas, Gethin P., Cowin, Gary J., Pearen, Michael A., Mardon, Karine, Stow, Jennifer L. and Muscat, George E. O. (2015). Ror-alpha deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white and brown adipose tissue. American Journal of Physiology: Endocrinology and Metabolism, 308 (2), E159-E171. doi: 10.1152/ajpendo.00056.2014
Cytokine secretion in macrophages: SNAREs, Rabs, and membrane trafficking

Murray, Rachael Zoe and Stow, Jennifer Lea (2014). Cytokine secretion in macrophages: SNAREs, Rabs, and membrane trafficking. Frontiers in Immunology, 5 (Article 538) 538, 538. doi: 10.3389/fimmu.2014.00538
On linear models and parameter identifiability in experimental biological systems

Lamberton, Timothy O., Condon, Nicholas D., Stow, Jennifer L. and Hamilton, Nicholas A. (2014). On linear models and parameter identifiability in experimental biological systems. Journal of Theoretical Biology, 358, 102-121. doi: 10.1016/j.jtbi.2014.05.028
Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

Luo, Lin, Wall, Adam A., Yeo, Jeremy C., Condon, Nicholas D., Norwood, Suzanne J., Schoenwaelder, Simone, Chen, Kaiwen W., Jackson, Shaun, Jenkins, Brendan J., Hartland, Elizabeth L., Schroder, Kate, Collins, Brett M., Sweet, Matthew J. and Stow, Jennifer L. (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5 (1) 4407, 4407.1-4407.13. doi: 10.1038/ncomms5407
Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation

Inder, Kerry L., Ruelcke, Jayde E., Petelin, Lara, Moon, Hyeongsun, Choi, Eunju, Rae, James, Blumenthal, Antje, Hutmacher, Dietmar, Saunders, Nicholas A., Stow, Jennifer L., Parton, Robert G. and Hill, Michelle M. (2014). Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation. Journal of Extracellular Vesicles, 3 (1) 23784, 23784.1-23784.14. doi: 10.3402/jev.v3.23784
Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits

Jagirdar, Kasturee, Smit, Darren J., Ainger, Stephen A., Lee, Katie J., Brown, Darren L., Chapman, Brett, Zhao, Zhen Zhen, Montgomery, Grant W., Martin, Nicholas G., Stow, Jennifer L., Duffy, David L. and Sturm, Richard A. (2014). Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits. Pigment Cell and Melanoma Research, 27 (4), 552-564. doi: 10.1111/pcmr.12253
PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

Low, Pei Ching, Manzanero, Silvia, Mohannak, Nika, Narayana, Vinod K., Nguyen, Tam H., Kvaskoff, David, Brennan, Faith H., Ruitenberg, Marc J., Gelderblom, Mathias, Magnus, Tim, Kim, Hyun Ah, Broughton, Brad R. S., Sobey, Christopher G., Vanhaesebroeck, Bart, Stow, Jennifer L., Arumugam, Thiruma V. and Meunier, Frédéric A. (2014). PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. Nature Communications, 5 (3450) 3450, 1-12. doi: 10.1038/ncomms4450
The Rho GTPase Rac1 is required for recycling endosome-mediated secretion of TNF in macrophages

Stanley, Amanda C., Wong, Colin X., Micaroni, Massimo, Venturato, Juliana, Khromykh, Tatiana, Stow, Jennifer L. and Lacy, Paige (2013). The Rho GTPase Rac1 is required for recycling endosome-mediated secretion of TNF in macrophages. Immunology and Cell Biology, 92 (3), 275-286. doi: 10.1038/icb.2013.90
Nobel Prize discovery paves the way for immunological traffic

Stow, Jennifer L. (2013). Nobel Prize discovery paves the way for immunological traffic. Nature Reviews Immunology, 13 (12), 839-841. doi: 10.1038/nri3564
Single-step protease cleavage elution for identification of protein-protein interactions from GST pull-down and mass spectrometry

Luo, Lin, King, Nathan P., Yeo, Jeremy C., Jones, Alun and Stow, Jennifer L. (2013). Single-step protease cleavage elution for identification of protein-protein interactions from GST pull-down and mass spectrometry. Proteomics, Accepted Article (1), 1-15. doi: 10.1002/pmic.201300315
High-throughput quantification of early stages of phagocytosis

Yeo, Jeremy Changyu, Wall, Adam Alexander, Stow, Jennifer Lea and Hamilton, Nicholas Ahti (2013). High-throughput quantification of early stages of phagocytosis. Biotechniques, 55 (3), 115-124. doi: 10.2144/000114075
Intracellular trafficking and secretion of inflammatory cytokines

Stow, Jennifer L. and Murray, Rachael Z. (2013). Intracellular trafficking and secretion of inflammatory cytokines. Cytokine and Growth Factor Reviews, 24 (3), 227-239. doi: 10.1016/j.cytogfr.2013.04.001
Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages

Micaroni, Massimo, Stanley, Amanda C., Khromykh, Tatiana, Venturato, Juliana, Wong, Colin X. F., Lim, Jet P., Marsh, Brad J., Storrie, Brian, Gleeson, Paul A. and Stow, Jennifer L. (2013). Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages. PloS One, 8 (2) e57034, e57034.1-e57034.17. doi: 10.1371/journal.pone.0057034
Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice

Tuong, Zewen K., Lau, Patrick, Yeo, Jeremy C., Pearen, Michael A., Wall, Adam A., Stanley, Amanda C., Stow, Jennifer L. and Muscat, George E. O. (2013). Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice. Endocrinology, 154 (1), 140-149. doi: 10.1210/en.2012-1889
Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model

Martin, Sally, Fernandez Rojo, Manuel A., Stanley, Amanda C., Bastiani, Michele, Okano, Satomi, Nixon, Susan J., Thomas, Gethin, Stow, Jennifer L. and Parton, Robert G. (2012). Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model. PLoS One, 7 (9) e46242, e46242. doi: 10.1371/journal.pone.0046242
Recycling endosome-dependent and -independent mechanisms for IL-10 secretion in LPS-activated macrophages

Stanley, A. C., Lieu, Z. Z., Wall, A. A., Venturato, J., Khromykh, T., Hamilton, N. A., Gleeson, P. A. and Stow, J. L. (2012). Recycling endosome-dependent and -independent mechanisms for IL-10 secretion in LPS-activated macrophages. Journal of Leukocyte Biology, 92 (6), 1227-1239. doi: 10.1189/jlb.0412191
Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo

Bastow, Edward R., Last, Karena, Golub, Sue, Stow, Jennifer L., Stanley, Amanda C. and Fosang, Amanda J. (2012). Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo. Biology Open, 1 (4), 318-328. doi: 10.1242/bio.2012547
VAMP3 regulates podosome organisation in macrophages and together with Stx4/SNAP23 mediates adhesion, cell spreading and persistent migration

Veale, Kelly J., Offenhauser, Carolin, Lei, Nazi, Stanley, Amanda C., Stow, Jennifer L. and Murray, Rachael Z. (2011). VAMP3 regulates podosome organisation in macrophages and together with Stx4/SNAP23 mediates adhesion, cell spreading and persistent migration. Experimental Cell Research, 317 (13), 1817-1829. doi: 10.1016/j.yexcr.2011.04.016
Cytokine release from innate immune cells: Association with diverse membrane trafficking pathways

Lacy, Paige and Stow, Jennifer L. (2011). Cytokine release from innate immune cells: Association with diverse membrane trafficking pathways. Blood, 118 (1), 9-18. doi: 10.1182/blood-2010-08-265892
Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice

Wykes, Michelle N., Kay, Jason G., Manderson, Anthony, Liu, Xue Q., Brown, Darren L., Richard, Derek J., Wipasa, Jiraprapa, Jiang, Suhua H., Jones, Malcolm K., Janse, Chris J., Waters, Andrew P., Pierce, Susan K., Miller, Louis H., Stow, Jennifer L. and Good, Michael F. (2011). Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proceedings of the National Academy of Sciences of the United States of America, 108 (27), 11205-11210. doi: 10.1073/pnas.1108579108
Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages

Offenhäuser, Carolin, Lei, Nazi, Roy, Sandrine, Collins, Brett M., Stow, Jennifer L. and Murray, Rachael Z. (2011). Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Traffic, 12 (6), 762-773. doi: 10.1111/j.1600-0854.2011.01189.x
The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking

Beaumont, Kimberley A., Hamilton, Nicholas A., Moores, Matthew T., Brown, Darren L., Ohbayashi, Norihiko, Cairncross, Oliver, Cook, Anthony L., Smith, Aaron G., Misaki, Ryo, Fukuda, Mitsunori, Taguchi, Tomohiko, Sturm, Richard A. and Stow, Jennifer L. (2011). The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. Traffic, 12 (5), 627-643. doi: 10.1111/j.1600-0854.2011.01172.x
The myotubularin phosphatase MTMR4 regulates sorting from early endosomes

Naughtin, MJ, Sheffield, DA, Rahman, P, Hughes, WE, Gurung, R, Stow, JL, Nandurkar, HH, Dyson, JM and Mitchell, CA (2010). The myotubularin phosphatase MTMR4 regulates sorting from early endosomes. Journal of Cell Science, 123 (18), 3071-3083. doi: 10.1242/jcs.060103
Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion

Low, Pei Ching, Misaki, Ryo, Schroder, Kate, Stanley, Amanda C., Sweet, Matthew J., Teasdale, Rohan D., Vanhaesebroeck, Bart, Meunier, Frédéric A., Taguchi, Tomohiko and Stow, Jennifer L. (2010). Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion. Journal of Cell Biology, 190 (6), 1053-1065. doi: 10.1083/jcb.201001028
Cytokine secretion is distinct from secretion of cytotoxic granules in NK cells

Reefman, E, Kay, JG, Wood, SM, Offenhauser, C, Brown, DL, Roy, S, Stanley, AC, Low, PC, Manderson, AP and Stow, JL (2010). Cytokine secretion is distinct from secretion of cytotoxic granules in NK cells. Journal of immunology, 184 (9), 4852-4862. doi: 10.4049/jimmunol.0803954
Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

Kerr, Markus C., Wang, Jack T. H., Castro, Natalie A., Hamilton, Nicholas A., Town, Liam, Brown, Darren L., Meunier, Frederic A., Brown, Nat F., Stow, Jennifer L. and Teasdale, Rohan D. (2010). Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella. EMBO Journal, 29 (8), 1331-1347. doi: 10.1038/emboj.2010.28
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

Wood, S. M., Meeths, M, Chiang, S. C. C., Bechensteen, A. G., Boelens, J. J., Heilmann, C, Horiuchi, H, Rosthoj, S, Rutynowska, O, Winiarski, J, Stow, J. L., Nordenskjold, M, Henter, J. I., Ljunggren, H. G. and Bryceson, Y. T. (2009). Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. BLOOD, 114 (19), 4117-4127. doi: 10.1182/blood-2009-06-225359
Automated organelle-based colocalization in whole-cell imaging

Woodcroft, B. J., Hammond, L, Stow, J. L. and Hamilton, N. A. (2009). Automated organelle-based colocalization in whole-cell imaging. Cytometry Part A, 75A (11), 941-950. doi: 10.1002/cyto.a.20786
Cyclosporin A Decreases Apolipoprotein E Secretion from Human Macrophages via a Protein Phosphatase 2B-dependent and ATP-binding Cassette Transporter A1 (ABCA1)-independent Pathway

Kockx, Maaike, Guo, Dongni Lily, Traini, Mathew, Gaus, Katharina, Kay, Jason, Wimmer-Kleikamp, Sabine, Rentero, Carles, Burnett, John R., Le Goff, Wilfried, Van Eck, Miranda, Stow, Jennifer L., Jessup, Wendy and Kritharides, Leonard (2009). Cyclosporin A Decreases Apolipoprotein E Secretion from Human Macrophages via a Protein Phosphatase 2B-dependent and ATP-binding Cassette Transporter A1 (ABCA1)-independent Pathway. Journal of Biological Chemistry, 284 (36), 24144-24154. doi: 10.1074/jbc.M109.032615
Cytokine secretion in macrophages and other cells: Pathways and mediators

Stow, J., Low, P. C., Offenhauser, C. and Sangernami, D. (2009). Cytokine secretion in macrophages and other cells: Pathways and mediators. Immunobiology, 214 (7), 601-612. doi: 10.1016/j.imbio.2008.11.005
Analysis of Cultured Human Melanocytes Based on Polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P Loci

Cook, Anthony L., Chen, Wei, Thurber, Amy E., Smit, Darren J., Smith, Aaron G., Bladen, Timothy G., Brown, Darren L., Duffy, David L., Pastorino, Lorenza, Bianchi-Scarra, Giovanna, Leonard, J. Helen, Stow, Jennifer L. and Sturm, Richard A. (2009). Analysis of Cultured Human Melanocytes Based on Polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P Loci. Journal of Investigative Dermatology, 129 (2), 392-405. doi: 10.1038/jid.2008.211
Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis

Desclozeaux, Marion, Venturato, Juliana, Wylie, Fiona G., Kay, Jason G., Joseph, Shannon R., Le, Huong T. and Stow, Jennifer L. (2008). Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis. Americal Journal of Physiology: Cell Physiology, 295 (2), C545-C556. doi: 10.1152/ajpcell.00097.2008
The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans

WellsChristineA, Salvage-JonesJudithA, LiXin, HitchensKelly, ButcherSuzanne, MurrayRachaelZ, Beckhouse, Anthony G., LoYu-Lan-Sandra, ManzaneroSilvia, CobboldChristian, SchroderKate, MaBo, OrrSally, StewartLauren, LebusDaniel, SobieszczukPeter, HumeDavidA, StowJennifer, BlanchardHelen, AshmanRobertB, RRich and MHogan (2008). The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. Journal of Immunology, 180 (11), 7404-7413. doi: 10.4049/jimmunol.180.11.7404
A trans-golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo

Lieu, Z. Z., Lock, J. G., Hammond, L. A., La Gruta, N. L., Stow, J. L. and Gleeson, P. A. (2008). A trans-golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo. Proceedings of the National Academy of Sciences of the United States of America, 105 (9), 3351-3356. doi: 10.1073/pnas.0800137105
Fusion, fission, and secretion during phagocytosis

Huynh, Kassidy K., Kay, Jason G., Stow, Jennifer L. and Grinstein, Sergio (2007). Fusion, fission, and secretion during phagocytosis. Physiology, 22 (6), 366-372. doi: 10.1152/physiol.00028.2007
Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles (vol 16, pg 2249, 2007)

Beaumont, Kimberley A., Shekar, Sri N., Newton, Richard A., James, Michael R., Stow, Jennifer L., Duffy, David L. and Sturm, Richard A. (2007). Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles (vol 16, pg 2249, 2007). Human Molecular Genetics, 16 (23), 2988-2988. doi: 10.1093/hmg/ddm268
Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles

Beaumont, Kimberley A., Shekar, Sri L., Newton, Richard A., James, Michael R., Stow, Jennifer L., Duffy, David L. and Sturm, Richard A. (2007). Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles. Human Molecular Genetics, 16 (18), 2249-2260. doi: 10.1093/hmg/ddm177
EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin

Bryant, D. M., Kerr, M. C., Hammond, L. A., Joseph, S. R., Mostov, K. E., Teasdale, R. D. and Stow, J. L. (2007). EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Journal of Cell Science, 120 (10), 1818-1828. doi: 10.1242/jcs.000653
Secretion of apolipoprotein E from macrophages occurs via a protein kinase A- and calcium-dependent pathway along the microtubule network

Kockx, M., Guo, D. N. L., Huby, T., Lesnik, P., Kay, J., Sabaretnam, T., Jary, E., Hill, M., Gaus, K., Chapman, J., Stow, J. L., Jessup, W. and Kritharides, L. (2007). Secretion of apolipoprotein E from macrophages occurs via a protein kinase A- and calcium-dependent pathway along the microtubule network. Circulation Research, 101 (6), 607-616. doi: 10.1161/CIRCRESAHA.107.157198
Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFα

Manderson, A, P., Kay, J. G., Hammond, L. A., Brown, D. L. and Stow, J. L. (2007). Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFα. Journal of Cell Biology, 178 (1), 57-69. doi: 10.1083/jcb.200612131
The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis

Greenwood, K. P., Daly, N. L., Brown, D. L., Stow, J. L. and Craik, D. J. (2007). The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis. International Journal of Biochemistry & Cell Biology, 39 (12), 2252-2264. doi: 10.1016/j.biocel.2007.06.016
The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure

Derby, Merran C., Lieu, Zi Zhao, Brown, Darren, Stow, Jennifer L., Goud, Bruno and Gleeson, Paul A. (2007). The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic, 8 (6), 758-773. doi: 10.1111/j.1600-0854.2007.00563.x
SNAREing immunity: the role of SNAREs in the immune system

Stow, Jennifer L., Manderson, Anthony P. and Murray, Rachael Z. (2006). SNAREing immunity: the role of SNAREs in the immune system. Nature Reviews Immunology, 6 (12), 919-929. doi: 10.1038/nri1980
Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup

Kay, J. G., Murray, R. Z., Pagan, J. K. and Stow, J. L. (2006). Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup. Journal of Biological Chemistry, 281 (17), 11949-11954. doi: 10.1074/jbc.M600857200
A role for the phagosome in cytokine secretion

Murray, R. Z., Kay, J. G., Sangermani, D. G. and Stow, J. L. (2005). A role for the phagosome in cytokine secretion. Science, 310 (5753), 1492-1495. doi: 10.1126/science.1120225
Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk

Beaumont, K. A., Newton, R. A., Smit, D. J., Leonard, J. H., Stow, J. L. and Sturm, R. A. (2005). Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. Human Molecular Genetics, 14 (15), 2145-2154. doi: 10.1093/hmg/ddi219
E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by Golgin-97

Lock, J. G., Hammond, L. A., Houghton, F., Gleeson, P. A. and Stow, J. L. (2005). E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by Golgin-97. Traffic, 6 (12), 1142-1156. doi: 10.1111/j.1600-0854.2005.00349.x
Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor

Bryant, David M. and Stow, Jennifer L. (2005). Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor. Traffic, 6 (10), 947-954. doi: 10.1111/j.1600-0854.2005.00332.x
Polarized trafficking of E-cadherin is regulated by Rac1 and Cdc42 in Madin-Darby canine kidney cells

Wang, B., Wylie, F. G., Teasdale, R. D. and Stow, J. L. (2005). Polarized trafficking of E-cadherin is regulated by Rac1 and Cdc42 in Madin-Darby canine kidney cells. American Journal of Physiology-cell Physiology, 288 (6), C1411-C1419. doi: 10.1152/ajpcell.00533.2004
Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin

Lock, John G. and Stow, Jennifer L. (2005). Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin. Molecular Biology of The Cell, 16 (4), 1744-1755. doi: 10.1091/mbc.E04-10-0867
Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin

Bryant, David M., Wylie, Fiona G. and Stow, Jennifer L. (2005). Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherin. Molecular Biology of The Cell, 16 (1), 14-23. doi: 10.1091/mbc.E04-09-0845
Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-alpha

Murray, Rachael Z., Wylie, Fiona G., Khromykh, Tatiana, Hume, David A. and Stow, Jennifer L. (2005). Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-alpha. Journal of Biological Chemistry, 280 (11), 10478-10483. doi: 10.1074/jbc.M414420200
The ins and outs of E-cadherin trafficking

Bryant, David M. and Stow, Jennifer. L. (2004). The ins and outs of E-cadherin trafficking. Trends In Cell Biology, 14 (8), 427-434. doi: 10.1016/j.tcb.2004.07.007
Domains of the TGN: Coats, tethers and G proteins

Gleeson, Paul A., Lock, John G., Luke, Michael R. and Stow, Jennifer L. (2004). Domains of the TGN: Coats, tethers and G proteins. Traffic, 5 (5), 315-326. doi: 10.1111/j.1398-9219.2004.00182.x
ICAT is a multipotent inhibitor of beta-catenin. Focus on "Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions"

Stow, Jennifer L. (2004). ICAT is a multipotent inhibitor of beta-catenin. Focus on "Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions". American Journal of Physiology - Cell Physiology, 286 (4), C745-C746. doi: 10.1152/ajpcell.00563.2003
Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN

Derby, M. C., van Vilet, C., Brown, D., Luke, M. R., Lei, L., Hong, W. J., Stow, J. L. and Gleeson, P. A. (2004). Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN. Journal of Cell Science, 117 (24), 5865-5874. doi: 10.1242/jcs.01497
N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking

Shearwin-Whyatt, L. M., Brown, D. L., Wylie, F. G., Stow, J. L. and Kumar, S. (2004). N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. Journal of Cell Science, 117 (16), 3679-3689. doi: 10.1242/jcs.01212
Targeting of a tropomyosin isoform to short microfilaments associated with the Golgi complex

Percival, J. M., Hughes, J. A. I., Brown, D. L., Schevzov, G., Heimann, K., Vrhovski, B., Bryce, N., Stow, J. L. and Gunning, P. W. (2004). Targeting of a tropomyosin isoform to short microfilaments associated with the Golgi complex. Molecular Biology of The Cell, 15 (1), 268-280. doi: 10.1091/mbc.E03-03-0176
Characterization of E-cadherin endocytosis in isolated MCF-7 and Chinese hamster ovary cells - The initial fate of unbound E-cadherin

Paterson, Andrew D., Parton, Robert G., Ferguson, Charles, Stow, Jennifer L. and Yap, Alpha S. (2003). Characterization of E-cadherin endocytosis in isolated MCF-7 and Chinese hamster ovary cells - The initial fate of unbound E-cadherin. Journal of Biological Chemistry, 278 (23), 21050-21057. doi: 10.1074/jbc.M300082200
Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: Pigmentation marker, ultrastructural and UV-survival studies

Leonard, J. Helen, Marks, Lisa H., Chen, Wei, Cook, Anthony L., Boyle, Glen M., Smit, Darren J., Brown, Darren L., Stow, Jennifer L., Parsons, Peter G. and Sturm, Richard A. (2003). Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: Pigmentation marker, ultrastructural and UV-survival studies. Pigment Cell Research, 16 (3), 198-207. doi: 10.1034/j.1600-0749.2003.00033.x
The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes

Sturm, R. A., Duffy, D. L., Box, N. F., Chen, W., Smit, D. J., Brown, D. L., Stow, J. L., Leonard, J. H. and Martin, N. G. (2003). The role of melanocortin-1 receptor polymorphism in skin cancer risk phenotypes. Pigment Cell Research, 16 (3), 266-272. doi: 10.1034/j.1600-0749.2003.00041.x
The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion

Pagan, J. K., Wylie, F. G., Joseph, S. R., Widberg, C., Bryant, N. J., James, D. E. and Stow, J. L. (2003). The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Current Biology, 13 (2), 156-160. doi: 10.1016/S0960-9822(03)00006-X
Contextual binding of p120ctn to E-cadherin at the basolateral plasma membrane in polarized epithelia

Miranda, K. C., Joseph, S. R., Yap, A. S., Teasdale, R. D. and Stow, J. L. (2003). Contextual binding of p120ctn to E-cadherin at the basolateral plasma membrane in polarized epithelia. Journal of Biological Chemistry, 278 (44), 43480-43488. doi: 10.1074/jbc.M305525200
GAIP participates in budding of membrane carriers at the trans-Golgi network

Wylie, F. G., Lock, J. G., Jamriska, L., Khromykh, T., Brown, D. L. and Stow, J. L. (2003). GAIP participates in budding of membrane carriers at the trans-Golgi network. Traffic, 4 (3), 175-189. doi: 10.1034/j.1600-0854.2003.00106.x
GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network

Luke, M. R., Kjer-Nielsen, L., Brown, D. L., Stow, J. L. and Gleeson, P. A. (2003). GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. Journal of Biological Chemistry, 278 (6), 4216-4226. doi: 10.1074/jbc.M210387200
Expression of Heparan Sulphate N-deacetylase/N-sulphotransferase by Vascular Smooth Muscle Cells

Bingley, John A., Hayward, Ian P., Girjes, Adeeb A., Campbell, Gordon R., Humphries, Donald E., Stow, Jennifer L. and Campbell, Julie H. (2002). Expression of Heparan Sulphate N-deacetylase/N-sulphotransferase by Vascular Smooth Muscle Cells. The Histochemical Journal, 34 (3-4), 131-137. doi: 10.1023/A:1020938430120
Dynamin-dependent endocytosis is necessary for convergent-extension movements in Xenopus animal cap explants

Jarrett, O., Stow, J. L., Yap, A. S. and Key, B. (2002). Dynamin-dependent endocytosis is necessary for convergent-extension movements in Xenopus animal cap explants. International Journal of Developmental Biology, 46 (4), 467-473.
Protein kinase C regulates endocytosis and recycling of E-cadherin

Le, T. L., Joseph, S. R., Yap, A. S. and Stow, J. L. (2002). Protein kinase C regulates endocytosis and recycling of E-cadherin. American Journal of Physiology-cell Physiology, 283 (2), C489-C499. doi: 10.1152/ajpcell.00566.2001
Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein

Little, Melissa H., Wilkinson, Lorine, Brown, Darren L., Piper, Michael, Yamada, Toshiya and Stow, Jennifer L. (2001). Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein. American Journal of Physiology-cell Physiology, 281 (2), C486-C495. doi: 10.1152/ajpcell.2001.281.2.c486
A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells

Miranda, Kevin C., Khromykh, Tatiana, Christy, Perpetina, Le, Tam Luan, Gottardi, Cara J., Yap, Alpha S., Stow, Jennifer L. and Teasdale, Rohan D. (2001). A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells. Journal of Biological Chemistry, 276 (25), 22565-22572. doi: 10.1074/jbc.M101907200
Endocytosis of uncleaved tumor necrosis factor-alpha in macrophages

Shurety, Wenda, Pagan, Julia K., Prins, Johannes B. and Stow, Jennifer L. (2001). Endocytosis of uncleaved tumor necrosis factor-alpha in macrophages. Laboratory Investigation, 81 (1), 107-117. doi: 10.1038/labinvest.3780216
The GRIP domain is a specific targeting sequence for a population of trans-Golgi network derived tubulo-vesicular carriers

Brown, D. L., Heimann, K., Lock, J., Kjer-Nielsen, L., van Vliet, C., Stow, J. L. and Gleeson, P. A. (2001). The GRIP domain is a specific targeting sequence for a population of trans-Golgi network derived tubulo-vesicular carriers. Traffic, 2 (5), 336-344. doi: 10.1034/j.1600-0854.2001.002005336.x
Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.

Shurety, W., Merino-Trigo, A., Brown, D. L., Hume, D. A. and Stow, J. L. (2000). Localization of post -golgi trafficking of tumor necrosis factor-a in macrophages.. Journal of Interferon and Cytokine Research, 20 (4), 427-438. doi: 10.1089/107999000312379
Recycling of E-Cadherin: a potential mechanism for regulating cadherin dynamics

Le, T. L., Yap, A. S. and Stow, J. L. (1999). Recycling of E-Cadherin: a potential mechanism for regulating cadherin dynamics. The Journal of Cell Biology, 146 (1), 219-232. doi: 10.1083/jcb.146.1.219
Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles

Heimann, K. R., Percival, J. M., Weinberger, R., Gunning, P. and Stow, J. L. (1999). Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles. Journal of Biological Chemistry, 274 (16), 10743-10750. doi: 10.1074/jbc.274.16.10743
GAIP, a Galpha(i-3)-binding protein, is associated with Golgi-derived vesicles and protein trafficking

Wylie, Fiona, Heimann, Kirsten R., Luan Le, Tam, Brown, Darren, Rabnott, Glenn C. and Stow, Jennifer (1999). GAIP, a Galpha(i-3)-binding protein, is associated with Golgi-derived vesicles and protein trafficking. American Journal of Physiology, 276 (2), C497-C506. doi: 10.1152/ajpcell.1999.276.2.c497
Vesicle budding on Golgi membranes: Regulation by G proteins and myosin motors

Stow, JL and Heimann, K (1998). Vesicle budding on Golgi membranes: Regulation by G proteins and myosin motors. Biochimica Et Biophysica Acta-Molecular Cell Research, 1404 (1-2), 161-171. doi: 10.1016/S0167-4889(98)00055-X
Budding roles for myosin II on the Golgi

Stow, JL, Faith, KR and Burgess, DR (1998). Budding roles for myosin II on the Golgi. Trends in Cell Biology, 8 (4), 138-141. doi: 10.1016/S0962-8924(98)01238-0
Fluid-phase markers in the basolateral endocytic pathway accumulate in response to the actin assembly-promoting drug Jasplakinolide

Shurety, Wenda, Stewart, Nancy L. and Stow, Jennifer L (1998). Fluid-phase markers in the basolateral endocytic pathway accumulate in response to the actin assembly-promoting drug Jasplakinolide. Molecular Biology of the Cell, 9 (4), 957-975. doi: 10.1091/mbc.9.4.957
Distinct localization of renin and GLUT-4 in juxtaglomerular cells of mouse kidney

Anderson, TJ, Martin, S, Berka, JL, James, DE, Slot, JW and Stow, JL (1998). Distinct localization of renin and GLUT-4 in juxtaglomerular cells of mouse kidney. American Journal of Physiology-Renal Physiology, 274 (1), F26-F33. doi: 10.1152/ajprenal.1998.274.1.f26
Myosin II is associated with Golgi membranes: identification of p200 as nonmuscle myosin II on Golgi-derived vesicles

Ikonen, E, deAlmeid, JB, Fath, KR, Burgess, DR, Ashman, K, Simons, K and Stow, JL (1997). Myosin II is associated with Golgi membranes: identification of p200 as nonmuscle myosin II on Golgi-derived vesicles. Journal of Cell Science, 110 (18), 2155-2164.
Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network

Humphries, Donald E., Sullivan, Brandon M., Aleixo, M. Deize and Stow, Jennifer L. (1997). Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network. Biochemical Journal, 325 (2), 351-357. doi: 10.1042/bj3250351
Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network

Humphries, DE, Sullivan, BM, Aleixo, MD and Stow, JL (1997). Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network. Biochemical Journal, 325, 351-357.
p230 is associated with vesicles budding from the trans-Golgi network

Gleeson, PA, Anderson, TJ, Stow, JL, Griffiths, G, Toh, BH and Matheson, F (1996). p230 is associated with vesicles budding from the trans-Golgi network. Journal of Cell Science, 109 (12), 2811-2821.
Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta

Dignass, AU, Stow, JL and Babyatsky, MW (1996). Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta. Gut, 38 (5), 687-693. doi: 10.1136/gut.38.5.687
Role of myristoylation in membrane attachment and function of G alpha(1-3) on Golgi membranes

Brand, SH, Holtzman, EJ, Scher, DA, Ausiello, DA and Stow, JL (1996). Role of myristoylation in membrane attachment and function of G alpha(1-3) on Golgi membranes. American Journal of Physiology-Cell Physiology, 270 (5), C1362-C1369.
Role of myristoylation in membrane attachment and function of Gαi-3 on Golgi membranes

Brand, Susan H., Holtzman, Eliezer J., Scher, Daniel A., Ausiello, Dennis A. and Stow, Jennifer L. (1996). Role of myristoylation in membrane attachment and function of Gαi-3 on Golgi membranes. American Journal of Physiology - Cell Physiology, 270 (5 39-5)
Protein trafficking and polarity in kidney epithelium: From cell biology to physiology

Brown, D and Stow, JL (1996). Protein trafficking and polarity in kidney epithelium: From cell biology to physiology. Physiological Reviews, 76 (1), 245-297. doi: 10.1152/physrev.1996.76.1.245
Distinct Coated Vesicles Labeled for P200 Bud From Trans-Golgi Network Membranes

Narula, N and Stow, JL (1995). Distinct Coated Vesicles Labeled for P200 Bud From Trans-Golgi Network Membranes. Proceedings of the National Academy of Sciences of the United States of America, 92 (7), 2874-2878. doi: 10.1073/pnas.92.7.2874
Regulation of vesicular transport by GTP-binding proteins

Stow, Jennifer L. (1995). Regulation of vesicular transport by GTP-binding proteins. Current Opinion in Nephrology and Hypertension, 4 (5), 421-425. doi: 10.1097/00041552-199509000-00009
Moving Things Around - the Structural Basis of Intracellular Protein Trafficking - November 17-20, 1993 Chatham-Bars-Inn, Chatham, Ma

Brown, D and Stow, JL (1994). Moving Things Around - the Structural Basis of Intracellular Protein Trafficking - November 17-20, 1993 Chatham-Bars-Inn, Chatham, Ma. Journal of the American Society of Nephrology, 4 (10), 1827-1831.
Targeting of Chimeric G-Alpha(I) Proteins to Specific Membrane Domains

Dealmeida, JB, Holtzman, EJ, Peters, P, Ercolani, L, Ausiello, DA and Stow, JL (1994). Targeting of Chimeric G-Alpha(I) Proteins to Specific Membrane Domains. Journal of Cell Science, 107 (3), 507-515.
Heterologous Expression of Delta-F508 Cftr Results in Decreased Sialylation of Membrane Glycoconjugates

Dosanjh, A, Lencer, W, Brown, D, Ausiello, DA and Stow, JL (1994). Heterologous Expression of Delta-F508 Cftr Results in Decreased Sialylation of Membrane Glycoconjugates. American Journal of Physiology, 266 (2), C360-C366. doi: 10.1152/ajpcell.1994.266.2.c360
Binding of the Cytosolic P200 Protein to Golgi Membranes Is Regulated by Heterotrimeric G-Proteins

Dealmeida, JB, Doherty, J, Ausiello, DA and Stow, JL (1993). Binding of the Cytosolic P200 Protein to Golgi Membranes Is Regulated by Heterotrimeric G-Proteins. Journal of Cell Science, 106 (4), 1239-1248.
Entry of Cholera-Toxin Into Polarized Human Intestinal Epithelial-Cells - Identification of An Early Brefeldin-A Sensitive Event Required for A(1)-Peptide Generation

Lencer, WI, Dealmeida, JB, Moe, S, Stow, JL, Ausiello, DA and Madara, JL (1993). Entry of Cholera-Toxin Into Polarized Human Intestinal Epithelial-Cells - Identification of An Early Brefeldin-A Sensitive Event Required for A(1)-Peptide Generation. Journal of Clinical Investigation, 92 (6), 2941-2951. doi: 10.1172/JCI116917
Identification of human intestinal trefoil factor: goblet cell-specific expression of a peptide targeted for apical secretion (Vol 268, Pg 6694, 1993)

Podolsky, Daniel K., Lynch-Devaney, Kathryn, Stow, Jennifer L., Oates, Philip, Murgue, Bernadette, DeBeaumont, Michelle, Sands, Bruce E. and Mahida, Yashwant R. (1993). Identification of human intestinal trefoil factor: goblet cell-specific expression of a peptide targeted for apical secretion (Vol 268, Pg 6694, 1993). Journal of Biological Chemistry, 268 (16), 12230-12230.
Identification of human intestinal trefoil factor: goblet cell-specific expression of a peptide targeted for apical secretion

Podolsky, Daniel K., Lynch-Devaney, Kathryn, Stow, Jennifer L., Oates, Philip, Murgue, Bernadette, DeBeaumont, Michelle, Sands, Bruce E. and Mahida, Yashwant R. (1993). Identification of human intestinal trefoil factor: goblet cell-specific expression of a peptide targeted for apical secretion. Journal of Biological Chemistry, 268 (9), 6694-6702.
Hyaluronate Is a Component of Crescents in Rat Autoimmune Glomerulonephritis

Nishikawa, K, Andres, G, Bhan, AK, McCluskey, RT, Collins, AB, Stow, JL and Stamenkovic, I (1993). Hyaluronate Is a Component of Crescents in Rat Autoimmune Glomerulonephritis. Laboratory Investigation, 68 (2), 146-153.
Distribution and Role of Heterotrimeric G-Proteins in the Secretory Pathway of Polarized Epithelial-Cells

Stow, JL and Dealmeida, JB (1993). Distribution and Role of Heterotrimeric G-Proteins in the Secretory Pathway of Polarized Epithelial-Cells. Journal of Cell Science, 1993 (Supplement 17), 33-39. doi: 10.1242/jcs.1993.supplement_17.6
Identification of a 200-kD, brefeldin-sensitive protein on Golgi membranes

Narula, N., McMorrow, I., Plopper, G., Doherty, J., Matlin, K. S., Burke, B. and Stow, J. L. (1992). Identification of a 200-kD, brefeldin-sensitive protein on Golgi membranes. Journal of Cell Biology, 117 (1), 27-38. doi: 10.1083/jcb.117.1.27
Purified epithelial Na+ channel complex contains the pertussis toxin-sensitive Gαi-3 protein

Ausiello, Dennis A., Stow, Jennifer L., Cantiello, Horacio F., De Almeida, J. Bruno and Benos, Dale J. (1992). Purified epithelial Na+ channel complex contains the pertussis toxin-sensitive Gαi-3 protein. Journal of Biological Chemistry, 267 (7), 4759-4765.
Actin-Filaments Regulate Epithelial Na+ Channel Activity

Cantiello, HF, Stow, JL, Prat, AG and Ausiello, DA (1991). Actin-Filaments Regulate Epithelial Na+ Channel Activity. American Journal of Physiology, 261 (5), C882-C888. doi: 10.1152/ajpcell.1991.261.5.c882
Heterogenous Localization of G-Protein Alpha-Subunits in Rat-Kidney

Stow, JL, Sabolic, I and Brown, D (1991). Heterogenous Localization of G-Protein Alpha-Subunits in Rat-Kidney. American Journal of Physiology, 261 (5), F831-F840. doi: 10.1152/ajprenal.1991.261.5.f831
A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells

Stow, J. L., Dealmeida, J. B., Narula, N., Holtzman, E. J., Ercolani, L. and Ausiello, D. A. (1991). A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells. Journal of Cell Biology, 114 (6), 1113-1124. doi: 10.1083/jcb.114.6.1113
Disruption of Microtubules Alters Polarity of Basement-Membrane Proteoglycan Secretion in Epithelial-Cells

Dealmeida, JB and Stow, JL (1991). Disruption of Microtubules Alters Polarity of Basement-Membrane Proteoglycan Secretion in Epithelial-Cells. American Journal of Physiology, 261 (1), C691-C700. doi: 10.1152/ajpcell.1991.261.1.c691
Disruption of microtubules alters polarity of basement membrane proteoglycan secretion in epithelial cells

De Almeida, J. B. and Stow, J. L. (1991). Disruption of microtubules alters polarity of basement membrane proteoglycan secretion in epithelial cells. American Journal of Physiology - Cell Physiology, 260 (4 29-4)
Regulation of the G-protein αi-2 subunit gene in LLC-PK1 renal cells and isolation of porcine genomic clones encoding the gene promoter

Holtzman, Eliezer J., Soper, Brian W., Stow, Jennifer L., Ausiello, Dennis A. and Ercolani, Louis (1991). Regulation of the G-protein αi-2 subunit gene in LLC-PK1 renal cells and isolation of porcine genomic clones encoding the gene promoter. Journal of Biological Chemistry, 266 (3), 1763-1771.
Membrane Localization of the Pertussis Toxin-Sensitive G-Protein Subunit-Alpha-I-2 and Subunit-Alpha-I-3 and Expression of a Metallothionein-Alpha-I-2 Fusion Gene in Llc-Pk1 Cells

Ercolani, L, Stow, JL, Boyle, JF, Holtzman, EJ, Lin, H, Grove, JR and Ausiello, DA (1990). Membrane Localization of the Pertussis Toxin-Sensitive G-Protein Subunit-Alpha-I-2 and Subunit-Alpha-I-3 and Expression of a Metallothionein-Alpha-I-2 Fusion Gene in Llc-Pk1 Cells. Proceedings of the National Academy of Sciences of the United States of America, 87 (12), 4635-4639. doi: 10.1073/pnas.87.12.4635
Basement-Membrane Heparan-Sulfate Proteoglycan Is the Main Proteoglycan Synthesized by Glomerular Epithelial-Cells in Culture

Stow, JL, Soroka, CJ, Mackay, K, Striker, L, Striker, G and Farquhar, MG (1989). Basement-Membrane Heparan-Sulfate Proteoglycan Is the Main Proteoglycan Synthesized by Glomerular Epithelial-Cells in Culture. American Journal of Pathology, 135 (4), 637-646.
Dependence On Ph of Polarized Sorting of Secreted Proteins

Caplan, MJ, Stow, JL, Newman, AP, Madri, J, Anderson, HC, Farquhar, MG, Palade, GE and Jamieson, JD (1987). Dependence On Ph of Polarized Sorting of Secreted Proteins. Nature, 329 (6140), 632-635. doi: 10.1038/329632a0
Distinctive populations of basement membrane and cell membrane heparan sulfate proteoglycans are produced by cultured cell lines

Stow, J. L. and Farquhar, M. G. (1987). Distinctive populations of basement membrane and cell membrane heparan sulfate proteoglycans are produced by cultured cell lines. Journal of Cell Biology, 105 (1), 529-539. doi: 10.1083/jcb.105.1.529
Antibodies to Basement-Membrane Heparan-Sulfate Proteoglycans Bind to the Laminae Rarae of the Glomerular-Basement-Membrane (Gbm) and Induce Subepithelial Gbm Thickening

Miettinen, A, Stow, JL, Mentone, S and Farquhar, MG (1986). Antibodies to Basement-Membrane Heparan-Sulfate Proteoglycans Bind to the Laminae Rarae of the Glomerular-Basement-Membrane (Gbm) and Induce Subepithelial Gbm Thickening. Journal of Experimental Medicine, 163 (5), 1064-1084. doi: 10.1084/jem.163.5.1064
Basement-Membrane Heparan-Sulfate Proteoglycans Are Concentrated in the Laminae Rarae and in Podocytes of the Rat Renal Glomerulus

Stow, JL, Sawada, H and Farquhar, MG (1985). Basement-Membrane Heparan-Sulfate Proteoglycans Are Concentrated in the Laminae Rarae and in Podocytes of the Rat Renal Glomerulus. Proceedings of the National Academy of Sciences of the United States of America, 82 (10), 3296-3300. doi: 10.1073/pnas.82.10.3296
Heparan sulfate proteoglycans are concentrated on the sinusoidal plasmalemmal domain and in intracellular organelles of hepatocytes

Stow, J. L., Kjellen, L., Unger, E., Hook, M. and Farquhar, M. G. (1985). Heparan sulfate proteoglycans are concentrated on the sinusoidal plasmalemmal domain and in intracellular organelles of hepatocytes. Journal of Cell Biology, 100 (3), 975-980. doi: 10.1083/jcb.100.3.975
Biosynthesis of Proteoglycans by Isolated Rabbit Glomeruli

Stow, JL, Glasgow, EF, Handley, CJ and Hascall, VC (1983). Biosynthesis of Proteoglycans by Isolated Rabbit Glomeruli. Archives of Biochemistry and Biophysics, 225 (2), 950-957. doi: 10.1016/0003-9861(83)90110-8
Involvement of the Macrophage in Experimental Chronic Immune-Complex Glomerulonephritis

Becker, GJ, Hancock, WW, Stow, JL, Glasgow, EF, Atkins, RC and Thomson, NM (1982). Involvement of the Macrophage in Experimental Chronic Immune-Complex Glomerulonephritis. Nephron, 32 (3), 227-233. doi: 10.1159/000182850
Immunological studies of brain-specific antigens

Helme, R. D. and Stow, J. L. (1981). Immunological studies of brain-specific antigens. Clinical and experimental neurology, 17, 211-222.
Morphological-Studies of Outgrowth From Glomeruli in Tissue-Culture

Glasgow, EF, Stow, JL and Atkins, RC (1980). Morphological-Studies of Outgrowth From Glomeruli in Tissue-Culture. Micron, 11 (3-4), 465-466. doi: 10.1016/0047-7206(80)90098-9

Conference Publication

SPATIOTEMPORAL REGULATION OF RP105 SUBCELLULAR LOCALIZATION SHAPES ENDOSOMAL TLR4 SIGNALING

Mathmann, Carmen, Schultz, Thomas, Ongtengco, Cherica Felize J., Dalton, Emma, Domínguez Cadena, Leslie C., Zamoshnikova, Alina, Stow, Jennifer L. and Blumenthal, Antje (2023). SPATIOTEMPORAL REGULATION OF RP105 SUBCELLULAR LOCALIZATION SHAPES ENDOSOMAL TLR4 SIGNALING. IMMUNOLOGY 2023 Meeting, Washington, DC, United States, 11 - 15 May 2023. Rockville, MD, United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.160.06
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes

Guo, D., Lui, G. Y., Wilmott, J. S., Tikoo, S., Brown, D. L., Mann, G. J., Scolyer, R. A., Stow, J. L., Weninger, W., Beaumont, K. A. and Haass, N. (2019). RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes. 46th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Munich, GERMANY, MAR 13-16, 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease

Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E. and Sweet, M. (2018). RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease. International Liver Congress (ILC), Paris, France, 11-15 April, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(18)31040-7
A new Toll-like receptor adaptor protein that provides specificity to inflammatory cytokine production from macrophages

Luo, L., Bokil, N., Lansdaal, N., Wall, A., Marceline, F., Guo, Z., Alexandrov, K., Ross, I, Hibbs, M., Stow, J. and Sweet, M. (2016). A new Toll-like receptor adaptor protein that provides specificity to inflammatory cytokine production from macrophages. International Congress of Immunology (ICI), Melbourne Australia, 21-26 August 2016. HOBOKEN: Wiley-Blackwell.
Inflammatory response sculpting by neutrophil inflammasomes

Chen, K., Gross, C., Wall, A., Stacey, K., Stow, J., Sweet, M. and Schroder, K. (2016). Inflammatory response sculpting by neutrophil inflammasomes. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200
Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes

Vajjhala, P., Lu, A., Brown, D., Sagulenko, V, Schroder, K., Stow, J., Wu, H. and Stacey, K. (2016). Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

Low, Pei Ching (Regine), Manzanero, Silvia, Narayana, Vinod K., Nguyen, Tam H., Kvaskoff, David, Brennan, Faith H., Ruitenberg, Marc J., Gelderblom, Mathias, Magnus, Tim, Kim, Hyun Ah, Broughton, Brad R. S., Sobey, Christopher G., Vanhaesebroeck, Bart, Stow, Jennifer L., Arumugam, Thiruma V. and Meunier, Frederic A. (2014). PI3K delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, Australia, 26-29 October 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.126
Meeting report: Arf and Rab family G proteins

Casanova, James E., Hsu, Victor W., Jackson, Catherine L., Kahn, Richard A., Roy, Craig R., Stow, Jennifer L., Wandinger-Ness, Angela and Sztul, Elizabeth (2013). Meeting report: Arf and Rab family G proteins. Cambridge, United Kingdom: The Company of Biologists. doi: 10.1242/jcs.143610
Tumor-educated CD11c+/CD11bint/Gr-1-regulatory dendritic cells show a mutated pattern of trafficking molecules implicated in cytokine secretion.

Chiaruttini, Giulia, Soncin, Irene, Stow, Jennifer L., Peden, Andrew A. and Benvenuti, Federica (2013). Tumor-educated CD11c+/CD11bint/Gr-1-regulatory dendritic cells show a mutated pattern of trafficking molecules implicated in cytokine secretion.. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.TUMIMM2012-B4
Control central - at the intersection of exocytic and endocytic pathways

Stow, Jennifer Lea (2009). Control central - at the intersection of exocytic and endocytic pathways. BETHESDA: FEDERATION AMER SOC EXP BIOL.
The cyclic cystine knot miniprotein MCoTI-II crosses the plasma membrane by macropinocytosis

Greenwood, K. P., Daly, N. L., Brown, D. L., Stow, J. L. and Craik, D. J. (2007). The cyclic cystine knot miniprotein MCoTI-II crosses the plasma membrane by macropinocytosis. 20th American Peptide Society Symposium, Montreal, Canada, 26-30 June 2007 . Hoboken, NJ, United States: John Wiley & Sons.
Cytokine secretion and phagosome formation are spatially linked in macrophages

Murray, Rachael Z. and Stow, Jennifer L. (2005). Cytokine secretion and phagosome formation are spatially linked in macrophages. BASEL: SPRINGER BASEL AG.
Distinct intracellular transport pathways for the secretion of TNF and IL-6 in macrophages

Manderson, Anthony P. and Stow, Jennifer L. (2005). Distinct intracellular transport pathways for the secretion of TNF and IL-6 in macrophages.
Endocytosis of E-cadherin in polarized epithelia - Joint regulation of growth factor receptor internalisation and signaling

Stow, J, Bryant, D and Joseph, S (2004). Endocytosis of E-cadherin in polarized epithelia - Joint regulation of growth factor receptor internalisation and signaling. Experimental Biology 2004 Meeting, Washington Dc, Apr 17-21, 2004. BETHESDA: FEDERATION AMER SOC EXP BIOL.
p120ctn binds to the cadherin/catenin complex only after delivery to the basolateral plasma membrane in MDCK cells

Joseph, SR, Miranda, KC and Stow, JL (2002). p120ctn binds to the cadherin/catenin complex only after delivery to the basolateral plasma membrane in MDCK cells. 42nd Annual Meeting of the American-Society-for-Cell-Biology, San Francisco California, Dec 14-18, 2002. BETHESDA: AMER SOC CELL BIOLOGY.
Regulation of TNF trafficking in macrophages

Pagan, J. K., Wylie, F. G. and Stow, J. L. (2002). Regulation of TNF trafficking in macrophages. 42nd Annual Meeting of the American-Society-for-Cell-Biology, San Francisco California, 14-18 December 2002. Bethesda, MD United States: American Society for Cell Biology.
E-cadherin is internalized via a dynamin-dependent pathway and is trafficked to sorting endosomes

Paterson, A. D., Stow, J. L. and Yap, A. S. (2001). E-cadherin is internalized via a dynamin-dependent pathway and is trafficked to sorting endosomes. -, -, -. Bethesda, MD 20814 United States: American Society for Cell Biology.
Regulation of E-cadherin endocytosis by protein kinase C.

Stow, J. L., Le, T. L. C. and Yap, A. S. K. (2000). Regulation of E-cadherin endocytosis by protein kinase C.. 40th Anniversary Meeting, American Society for Cell Biology, Moscone Convention Center, San Francisco, California, 9-13 December 2000. Bethesda, MD: American Society for Cell Biology.
Endocytosis and recycling of E-cadherin: A potential mechanism for regulating cell adhesion

Le, T. L., Yap, A. S. and Stow, J. L. (1999). Endocytosis and recycling of E-cadherin: A potential mechanism for regulating cell adhesion. -, -, -. Bethesda, MD United States: American Society for Cell Biology.
Expression of heparan sulphate N-deacetylase/N-sulphotransferase in arteries and vascular smooth muscles in culture

Hayward, I. P., Bingley, J., Girjes, A. and Stow, J. (1999). Expression of heparan sulphate N-deacetylase/N-sulphotransferase in arteries and vascular smooth muscles in culture. Combio99, Gold Coast, QLD Australia, 27-30 September 1999. Kent Town, SA Australia: Australian Society for Biochemistry and Molecular Biology.
Membrane recruitment of RGS proteins by constitutively active Ga proteins

Wylie, F. G. and Stow, J. L. (1999). Membrane recruitment of RGS proteins by constitutively active Ga proteins. ComBio 99, Gold Coast, QLD Australia, 27-30 September 1999. Kent Town, SA Australia: Australian Society for Biochemistry & Molecular Biology.
Post-Golgi trafficking of TNF-a in macrophages

Shurety, W., Brown, D. L., Merino-Trigo, A., Smit, D. J., Hume, D. A. and Stow, J. L. (1999). Post-Golgi trafficking of TNF-a in macrophages. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology In..
Recycling of the Epithelial adhesion protein, E-Cadherin

Le, C., Yap, A. S. K. and Stow, J. L. (1999). Recycling of the Epithelial adhesion protein, E-Cadherin. ComBio 99, Gold Coast, QLD Australia, 27-30 September 1999. Kent Town, SA Australia: Australian Society for Biochemistry & Molecular Biology.
Role of myosins in vesicle formation at the golgi complex

Heimann, K. R., Shurety, W. and Stow, J. L. (1999). Role of myosins in vesicle formation at the golgi complex. 24th Annual Lorne Conference on Protein Structure and Function, Erskine House, Lorne, Vic., 7-11 Feb, 1999. Vic.: Lorne Australia.
Functional-Characterization of Cndi Mutations in the Vasopressin V2 Receptor Using Epitope-Tagged Receptors

Holtzman, EJ, Kolakowski, LF, Stow, JL, Brown, D and Ausiello, DA (1994). Functional-Characterization of Cndi Mutations in the Vasopressin V2 Receptor Using Epitope-Tagged Receptors.
Distribution and role of heterotrimeric G proteins in the secretory pathway of polarized epithelial cells

Stow, J. L. and De Almeida, J. B. (1993). Distribution and role of heterotrimeric G proteins in the secretory pathway of polarized epithelial cells.
Transforming Growth-Factor-Beta-1 Modulation of Intestinal Epithelial Injury in An Invivo Model of Acute Epithelial-Cell Injury in Rat Small-Intestine

Dignass, AU, Stow, JL and Podolsky, DK (1993). Transforming Growth-Factor-Beta-1 Modulation of Intestinal Epithelial Injury in An Invivo Model of Acute Epithelial-Cell Injury in Rat Small-Intestine.
Binding of the P200 Coat Protein to Golgi Membranes Is Regulated by Pertussis Toxin Sensitive G-Proteins

Dealmeida, J. B., Doherty, J., Narula, N., Burke, B., Matlin, K. and Stow, J. L. (1992). Binding of the P200 Coat Protein to Golgi Membranes Is Regulated by Pertussis Toxin Sensitive G-Proteins. unknown, unknown, unknown. Bethesda, MD, United States: American Society for Cell Biology.
Guanine nucleotide binding proteins regulate epithelial Na+ channels

Ausiello, D. A., Stow, J. L., Patenaude, C. R. and Cantiello, H. F. (1991). Guanine nucleotide binding proteins regulate epithelial Na+ channels.
Cortical Actin-Filaments Co-Localize with and Regulate Apical Epithelial Na+ Channels in A6 Cells

Cantiello, HF, Stow, JL and Ausiello, DA (1991). Cortical Actin-Filaments Co-Localize with and Regulate Apical Epithelial Na+ Channels in A6 Cells. AMER SOC CELL BIOLOGY.
Guanine-Nucleotide Binding-Proteins Regulate Epithelial Na+ Channels

Ausiello, DA, Stow, JL, Patenaude, CR and Cantiello, HF (1991). Guanine-Nucleotide Binding-Proteins Regulate Epithelial Na+ Channels. International Workshop On the Identification of the Cystic Fibrosis Gene : Recent Progress and New Research Strategies, Genoa Italy, Apr 09-11, 1990. NEW YORK: PLENUM PRESS DIV PLENUM PUBLISHING CORP.
The Core Protein of the Basement-Membrane Heparan-Sulfate Proteoglycan (Bmhspg) Is Secreted Basally From Mdck Cells Treated with B-D-Xyloside

Stow, JL and Farquhar, MG (1989). The Core Protein of the Basement-Membrane Heparan-Sulfate Proteoglycan (Bmhspg) Is Secreted Basally From Mdck Cells Treated with B-D-Xyloside.
Sorting of newly synthesized secretory and lysosomal proteins in polarized mdck cells

Caplan, MJ, Stow, JL, Newman, AP, Madri, JA, Anderson, HC, Farquhar, MG, Palade, GE and Jamieson, JD (1986). Sorting of newly synthesized secretory and lysosomal proteins in polarized mdck cells. Unknown, Unknown, Unknown. New York, United States: Rockefeller University Press.
Ultrastructural Studies of Cultured Glomeruli

Stow, JL, Glasgow, EF and Atkins, RC (1981). Ultrastructural Studies of Cultured Glomeruli.

Grants (Administered at UQ)

ARC Centre of Excellence in Quantum Biotechnology

(2023–2029) ARC Centres of Excellence
Cell fluid interaction: inside and outside cells

(2023–2026) ARC Discovery Projects
Gut Absorption of Constrained Peptides for Local and Systemic Targeting

(2023–2026) ARC Linkage Projects
Migration-Dependent Signalling in Macrophages

(2023–2026) ARC Discovery Projects
Rab GTPase regulation in Ciliogenesis and Polycystic Kidney Disease

(2021–2022) PKD Foundation of Australia Limited
GTPase regulation of cellular pathways in inflammation and cancer

(2020–2024) NHMRC Investigator Grants
A macrophage transmembrane adaptor: scaffolding and regulation in inflammation.

(2019–2022) NHMRC Project Grant
Machine learning for organelle selection and feature detection in live cells

(2018–2021) ARC Discovery Projects
Macrophage Polarisation and Control of Pulmonary Inflammation

(2018–2021) NHMRC Project Grant
Cryoelectron Microscopy Platform for Cellular Structural Biology

(2018) UQ Major Equipment and Infrastructure
ACRF Cancer Ultrastructure and Function Facility

(2017–2024) Australian Cancer Research Foundation
A novel mechanism for IL-1B secretion

(2017–2019) NHMRC Project Grant
Innate immune signalling in Mycobacterium tuberculosis infection

(2017–2019) NHMRC Project Grant
Lattice light sheet microscopy for imaging biology in real space and time

(2017) ARC Linkage Infrastructure, Equipment and Facilities
A new master adaptor protein for Toll-like Receptor signalling

(2016–2019) NHMRC Project Grant
Cellular regulation of receptor signalling and cytokine responses

(2016–2019) NHMRC Project Grant
Femtosecond laser imaging system for multi-photon microscopy

(2015) UQ Major Equipment and Infrastructure
Cholesterol and Hydroxycholesterol Shaping Phagocytosis

(2014–2016) ARC Discovery Projects
Clinical Academic Fellowship in Obesity Research and Prevention

(2012–2014) Queensland Health
Spinning Disk Confocal Microscopy system - Rapid live cell imaging of dynamic biological processes

(2012) UQ Major Equipment and Infrastructure
NHMRC Research Fellowship (PRF): Protein trafficking in inflammation and disease

(2011–2016) NHMRC Research Fellowship
Fighting infection: exploiting host-pathogen interactions (NHMRC Program Grant administered by Monash University)

(2011–2015) Monash University
SNARE-mediated perforin and cytokine release in NK cells

(2011–2013) ARC Discovery Projects
Automated Deconvolution optical microscope workstation for high-throughput and high-resolution/live cell analysis

(2011–2012) UQ Major Equipment and Infrastructure
Inhibition of pro-inflammatory cytokine secretion: A new route to therapeutics of chronic inflammatory disease (ARC Linkage Project administered by the University of Melbourne)

(2010–2013) University of Melbourne
Membrane fusion in macrophage function.

(2010–2013) NHMRC Project Grant
Regulating the secretion of inflammatory cytokines

(2010–2013) NHMRC Project Grant
Molecular, genetic and cellular analysis of melanisation in human pigmentation

(2010–2012) ARC Discovery Projects
The ACRF Cancer Biology Imaging Facility

(2009–2016) Australian Cancer Research Foundation
Recycling endosomes governing cell polarity and cytokine secretion

(2009–2014) NHMRC Project Grant
Modulation of endosomes for pathogen invasion

(2009–2011) NHMRC Project Grant
UQ Travel Award Category 1, Dr Paige Lacy

(2009) UQ Travel Grants Scheme
Molecular mechanism underlying the formation of transported vesicles involved in exo- and endocytosis

(2008–2010) Japan Science and Technology Agency
High Speed Fluorescence Imaging coupled with Total Internal Reflection Microscopy and Fluorescence Recovery After Photobleaching System

(2008–2009) ARC Linkage Infrastructure, Equipment and Facilities
Combined genetic and cellular analysis of melanisation to study variation in human pigmentation

(2007–2009) ARC Discovery Projects
SNARE-mediated protein trafficking in macrophages

(2007–2009) NHMRC Project Grant
The c-type lectin, Mincle, is a macrophage receptor for Candida albicans.

(2007–2009) NHMRC Project Grant
The molecular basis of macropinocytosis in mammalian cells: the composition of endosome proteins and their function

(2007–2009) ARC Discovery Projects
The nuclear growth hormone receptor- its actions and mechanism of nuclear translocation

(2007–2009) NHMRC Project Grant
PRINCIPAL RESEARCH FELLOWSHIP

(2006–2010) NHMRC Research Fellowship
E-Cadherin endocytosis in morphogenesis: Recycling and growth factor induced uptake

(2006–2008) NHMRC Project Grant
Polarized trafficking of E-cadherin in epithelial cells

(2006–2008) NHMRC Project Grant
Dynamic Imaging Facility for Cancer Biology

(2004–2011) Australian Cancer Research Foundation
LPS-regulated SNAREs and control of cytokine secretion in macrophages

(2004–2006) NHMRC Project Grant
Parallel genetic and cellular analysis of melanogensis: A new paradigm to study variation in pigmentation

(2004–2006) ARC Discovery Projects
NHMRC_Equipment Grant_IMB_Molecular Cell Biology

(2004–2005) NHMRC Equipment Grant
Cytokine trafficking and secretion in macrophages

(2003–2008) United States National Institutes of Health
Trafficking Of E-Cadherin In Epithelial Cells

(2003–2005) NHMRC Project Grant
Molecular Regulators of Cytokine Secretion

(2003) University of Queensland Research Development Grants Scheme
Reverse transfection arrays

(2002) University of Queensland Research Development Grants Scheme
NHMRC RESEARCH FELLOWSHIP

(2001–2005) NHMRC Fellowship Grant
Regulators of G Protein Signalling on the Golgi Complex

(2001–2005) NHMRC Project Grant
Cytokine secretion: A model for protein trafficking

(2000–2002) NHMRC Project Grant
Recycling of E-Cadherin: Implications for dynamic cell adhesion.

(2000–2002) NHMRC Project Grant
Regulation of TNF-a production by human adipose cells

(2000) Diabetes Australia Research Trust
Molecular regulation of GLUT4 targeting

(1999) Ramaciotti Foundation
G Protein Signalling on the Golgi Complex

(1998–2000) NHMRC Project Grant
Signal transduction modules

(1998) RL Cooper Medical Research Foundation Limited
Molecular analysts of protein function in the living cell

(1997–2000) Wellcome Trust
A new model of Heparin/Heparan Sulfate Biosynthesis

(1997–1999) ARC Australian Research Council (Large grants)
Membrane dynamics in protein trafficking

(1997–1999) NHMRC Project Grant
A mass spectrometric facility for peptide and protein analysis at the University of Queensland

(1996–1997) Viertel Foundation (Sylvia and Charles Viertel)
Localisation of secretory proteins in kidney cells

(1996) Ramaciotti Foundation
Zeiss axiophot microscope

(1996) NHMRC Equipment Grant
Regulation of proteoglycan secretion by G proteins on the Golgi complex

(1995–1997) NHMRC Project Grant - Standard
Establishment of the Australian Cancer Foundation Laboratory for the study of the molecular biology of cellular differentiation.

(1995) Australian Cancer Foundation for Medical Research
Program in electron microscopy in cell biology

(1995) Viertel Foundation (Sylvia and Charles Viertel)
Wellcome Senior Research Fellowship in Medical Science in Australia. Regulation of vesicle trafficking and secretion in epithelial cells

(1994–1999) Wellcome Trust

PhD and MPhil Supervision

Current Supervision

Barrier functions of the intestinal epithelium.

Doctor Philosophy — Principal Advisor
Cell death, inflammation, and macrophages in cardiac ischemia and metabolic disease

Doctor Philosophy — Principal Advisor
Other advisors:
- Associate Professor Nathan Palpant
- Dr Denuja Karunakaran
Gut inflammation: model systems and the development of anti-inflammatory peptide drugs.

Doctor Philosophy — Principal Advisor
Other advisors:
- Dr Thomas Durek
Performing microrheological measurements of biological compartments with rotational optical tweezers

Doctor Philosophy — Associate Advisor
Other advisors:
Structural and cellular analysis of Rab GTPases for drug development in cancer.

Doctor Philosophy — Associate Advisor
Other advisors:
- Professor Brett Collins
- Dr Quan Nguyen

Completed Supervision

Immune Signalling and Trafficking Regulated by Rab GTPases

(2022) Doctor Philosophy — Principal Advisor
Rab GTPase Regulation of Cell Surface Protrusions

(2022) Master Philosophy — Principal Advisor
Other advisors:
- Dr Andrew Mallett
Rab GTPase Regulation of Primary Cilia in Renal Epithelium

(2022) Doctor Philosophy — Principal Advisor
Other advisors:
- Dr Andrew Mallett
Inflammatory modulation in microglia: Macropinocytosis for receptor trafficking and signalling

(2020) Doctor Philosophy — Principal Advisor
Regulation of Rab8 in Toll-Like Receptor Signalling Pathways

(2020) Doctor Philosophy — Principal Advisor
Characterisation of Dorsal Ruffles in Activated Macrophages

(2018) Doctor Philosophy — Principal Advisor
Molecular Regulation of Phagocytosis and Signaling in Macrophages

(2016) Doctor Philosophy — Principal Advisor
The Role of Rab23 in Epithelial Morphogenesis, Polarity and Lumen Formation

(2014) Doctor Philosophy — Principal Advisor
SNARE-Mediated Secretion and Late Endosomes in Macrophages

(2012) Doctor Philosophy — Principal Advisor
Investigating the Role of Phosphoinositide 3-Kinase in Cytokine Trafficking and Secretion

(2011) Doctor Philosophy — Principal Advisor
Endosomal membrane fusion in macrophages and NK cells

(2009) Doctor Philosophy — Principal Advisor
Exocytosis and Endocytosis in LPS-activated macrophages: pathways and regulators

(2009) Doctor Philosophy — Principal Advisor
INTRACELLULAR CYTOKINE TRAFFICKING AND PHAGOCYTOSIS IN MACROPHAGES

() Doctor Philosophy — Principal Advisor
The regulators of E-cadherin trafficking in polarized epithelial cells

(2008) Doctor Philosophy — Principal Advisor
Other advisors:
- Associate Professor Rohan Teasdale
THE EXOCYTIC AND ENDOCYTIC TRAFFICKING OF E-CADHERIN IN EPITHELIAL CELLS

(2007) Doctor Philosophy — Principal Advisor
Other advisors:
- Associate Professor Rohan Teasdale
ANALYSIS OF CADHERIN AND RECEPTOR TYROSINE KINASE INTERACTIONS: TRAFFICKING AND FUNCTION

(2006) Doctor Philosophy — Principal Advisor
DYNAMIC IMAGING OF POST-GOLGI PROTEIN TRANSPORT

(2006) Doctor Philosophy — Principal Advisor
Other advisors:
- Associate Professor Rohan Teasdale
Regulation of Macrophage Polarisation and Inflammation.

(2022) Doctor Philosophy — Associate Advisor
SCIMP as a scaffold for kinases in innate immune receptor pathways

(2022) Doctor Philosophy — Associate Advisor
SCIMP: a novel TLR4 adaptor protein that fine-tunes inflammatory signalling in myeloid cells

(2021) Doctor Philosophy — Associate Advisor
Other advisors:
- Professor Matt Sweet
Retinoid-related Orphan Nuclear Receptor Alpha and Macrophages in Lipid Metabolism and Immunity

(2016) Doctor Philosophy — Associate Advisor
Computational methods to define the endosomal proteome

(2010) Doctor Philosophy — Associate Advisor
Other advisors:
- Associate Professor Rohan Teasdale
The molecular mechanism of MC1R association with skin cancer risk phenotypes

(2009) Doctor Philosophy — Associate Advisor
Other advisors:
- Associate Professor Rick Sturm
MOLECULAR CHANGES DEFINING THE TRANSITION FROM RADIAL TO VERTICAL GROWTH PHASE IN MELANOMA

(2006) Doctor Philosophy — Associate Advisor
Other advisors:
- Associate Professor Rick Sturm
THE ROLE OF P120-CTN IN REGULATING E-CADHERIN-MEDIATED ADHESION

(2005) Doctor Philosophy — Associate Advisor
Other advisors:
- Professor Alpha Yap
MEMBRANE MOVEMENTS OF E-CADHERIN

(2004) Doctor Philosophy — Associate Advisor
Other advisors:
- Professor Alpha Yap
POST-GOLGI TRAFFICKING IN THE MAMMALIAN SECRETORY PATHWAY

(2004) Doctor Philosophy — Associate Advisor
Other advisors:
- Associate Professor Rohan Teasdale
MOLECULAR DISSECTION OF PROTEIN TARGETTING IN EUCARYOTIC CELLS

(2003) Doctor Philosophy — Associate Advisor

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