The University of Queensland

Microbioreactor techniques for the production and spectroscopic characterization of microbial peptides

Khalil, Zeinab G., Salim, Angela A. and Capon, Robert J. (2020). Microbioreactor techniques for the production and spectroscopic characterization of microbial peptides. Peptide synthesis: methods and protocols. (pp. 303-322) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0227-0_21

Nuclear magnetic resonance case studies in marine natural products

Salim, Angela A., Piggott, Andrew M. and Capon, Robert J. (2017). Nuclear magnetic resonance case studies in marine natural products. Modern NMR Approaches to the Structure Elucidation of Natural Products: Volume 2: Data Acquisition and Applications to Compound Classes. (pp. 403-439) edited by Antony J. Williams, Gary E. Martin and David Rovnyak. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849734684-00403

Nuclear magnetic resonance case studies in microbial natural products

Piggott, Andrew M., Salim, Angela A. and Capon, Robert J. (2017). Nuclear magnetic resonance case studies in microbial natural products. Modern NMR Approaches to the Structure Elucidation of Natural Products: Volume 2: Data Acquisition and Applications to Compound Classes. (pp. 440-485) edited by Antony J. Williams, Gary E. Martin and David Rovnyak. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849734684-00440

Drug discovery from plants

Salim, Angela A., Chin, Young-Won and Kinghorn, A. Douglas (2008). Drug discovery from plants. Bioactive molecules and medicinal plants. (pp. 1-24) edited by K. G. Ramawat and J. M. Merillon. Berlin, Heidelberg, Germany: Springer Berlin Heidelberg. doi: 10.1007/978-3-540-74603-4_1

Jugiones A–D: Antibacterial Xanthone–Anthraquinone Heterodimers from Australian Soil-Derived Penicillium shearii CMB-STF067

Sritharan, Thulasi, Salim, Angela A., Khalil, Zeinab G. and Capon, Robert J. (2024). Jugiones A–D: Antibacterial Xanthone–Anthraquinone Heterodimers from Australian Soil-Derived Penicillium shearii CMB-STF067. Antibiotics, 13 (1) ARTN 97, 97. doi: 10.3390/antibiotics13010097

Miniaturized Cultivation Profiling Returns Indolo-Sesquiterpene Michael Adducts from the Australian Soil-Derived <i>Aspergillus terreus</i> CMB-SWF012

Sritharan, Thulasi, Salim, Angela A. and Capon, Robert J. (2023). Miniaturized Cultivation Profiling Returns Indolo-Sesquiterpene Michael Adducts from the Australian Soil-Derived Aspergillus terreus CMB-SWF012. Journal of Natural Products, 86 (12), 2703-2709. doi: 10.1021/acs.jnatprod.3c00869

Talarolides Revisited: Cyclic Heptapeptides from an Australian Marine Tunicate-Associated Fungus, Talaromyces sp. CMB-TU011

Salim, Angela A., Hussein, Waleed M., Dewapriya, Pradeep, Hoang, Huy N., Zhou, Yahao, Samarasekera, Kaumadi, Khalil, Zeinab G., Fairlie, David P. and Capon, Robert J. (2023). Talarolides Revisited: Cyclic Heptapeptides from an Australian Marine Tunicate-Associated Fungus, Talaromyces sp. CMB-TU011. Marine Drugs, 21 (9) 487, 487. doi: 10.3390/md21090487

Natural products as anthelmintics: safeguarding animal health

Salim, Angela A., Butler, Mark S., Blaskovich, Mark A. T., Henderson, Ian R. and Capon, Robert J. (2023). Natural products as anthelmintics: safeguarding animal health. Natural Product Reports, 40 (11), 1754-1808. doi: 10.1039/d3np00019b

Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril AB, Holmes, Kelly, Salim, Angela A, Mamidyala, Sreeman, Butler, Mark S, Robinson, Ashley S, Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L, Hogan, Benjamin M, De Val, Sarah, Capon, Robert J, Carroll, Jason S, Bailey, Timothy L, Koopman, Peter, Jauch, Ralf, Cooper, Matthew A, Gambin, Yann and Francois, Mathias (2023). Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 12 ARTN e90408. doi: 10.7554/elife.90408

Case studies in molecular network-guided marine biodiscovery

Khushi, Shamsunnahar, Salim, Angela A. and Capon, Robert J. (2023). Case studies in molecular network-guided marine biodiscovery. Marine Drugs, 21 (7) 413, 1-25. doi: 10.3390/md21070413

Glyclauxins A–E: dimeric oxaphenalenone aminoglycosides from an Australian wasp nest-derived fungus Talaromyces sp. CMB-MW102

Samarasekera, Kaumadi, Hussein, Waleed M., Wu, Taizong, Salim, Angela A. and Capon, Robert J. (2023). Glyclauxins A–E: dimeric oxaphenalenone aminoglycosides from an Australian wasp nest-derived fungus Talaromyces sp. CMB-MW102. Journal of Natural Products, 86 (3), 517-525. doi: 10.1021/acs.jnatprod.2c01069

Molecular networking and cultivation profiling reveals diverse natural product classes from an Australian soil-derived fungus Aspergillus sp. CMB-MRF324

Wu, Taizong, Salim, Angela A., Bernhardt, Paul V. and Capon, Robert J. (2022). Molecular networking and cultivation profiling reveals diverse natural product classes from an Australian soil-derived fungus Aspergillus sp. CMB-MRF324. Molecules, 27 (24) 9066, 1-17. doi: 10.3390/molecules27249066

Phoslactomycins revisited: polyketide tetrahydrofurans and lactones from an Australian wasp nest-derived Streptomyces sp. CMB-MW079

Salim, Angela A., Samarasekera, Kaumadi, Wu, Taizong and Capon, Robert J. (2022). Phoslactomycins revisited: polyketide tetrahydrofurans and lactones from an Australian wasp nest-derived Streptomyces sp. CMB-MW079. Organic Letters, 24 (40), 7328-7333. doi: 10.1021/acs.orglett.2c02791

Glenthmycins A–M: macrocyclic spirotetronate polyketide antibacterials from the Australian pasture plant-derived Streptomyces sp. CMB-PB041

Wu, Taizong, Salim, Angela A., Khalil, Zeinab G., Bernhardt, Paul V. and Capon, Robert J. (2022). Glenthmycins A–M: macrocyclic spirotetronate polyketide antibacterials from the Australian pasture plant-derived Streptomyces sp. CMB-PB041. Journal of Natural Products, 85 (6), 1641-1657. doi: 10.1021/acs.jnatprod.2c00444

Secreted NF-κB suppressive microbial metabolites modulate gut inflammation

Giri, Rabina, Hoedt, Emily C., Khushi, Shamsunnahar, Salim, Angela A., Bergot, Anne-Sophie, Schreiber, Veronika, Thomas, Ranjeny, McGuckin, Michael A., Florin, Timothy H., Morrison, Mark, Capon, Robert J., Ó Cuív, Páraic and Begun, Jakob (2022). Secreted NF-κB suppressive microbial metabolites modulate gut inflammation. Cell Reports, 39 (2) 110646, 110646. doi: 10.1016/j.celrep.2022.110646

Glenthenamines A–F: enamine pyranonaphthoquinones from the Australian pasture plant derived Streptomyces sp. CMB-PB042

Wu, Taizong, Salim, Angela A., Cui, Hui, Khalil, Zeinab G., Bernhardt, Paul V. and Capon, Robert J. (2022). Glenthenamines A–F: enamine pyranonaphthoquinones from the Australian pasture plant derived Streptomyces sp. CMB-PB042. Journal of Natural Products, 85 (2) acs.jnatprod.1c00821, 337-344. doi: 10.1021/acs.jnatprod.1c00821

Bhimamycin J, a rare benzo[f]isoindole-dione alkaloid from the marine-derived actinomycete Streptomyces sp. MS180069

Song, Fuhang, Yang, Na, Khalil, Zeinab G., Salim, Angela A., Han, Jiahui, Bernhardt, Paul V., Lin, Rui, Xu, Xiuli and Capon, Robert J. (2021). Bhimamycin J, a rare benzo[f]isoindole-dione alkaloid from the marine-derived actinomycete Streptomyces sp. MS180069. Chemistry and Biodiversity, 18 (11) e2100674, e2100674. doi: 10.1002/cbdv.202100674

Polycyclic C-deoxyaminoglycoside-polyketides from an Australian Pasture Plant Derived Streptomyces sp.

Wu, Taizong, Salim, Angela A., Khalil, Zeinab G. and Capon, Robert J. (2021). Polycyclic C-deoxyaminoglycoside-polyketides from an Australian Pasture Plant Derived Streptomyces sp.. Organic Letters, 23 (21) acs.orglett.1c02954, 8224-8228. doi: 10.1021/acs.orglett.1c02954

Millmerranones A–F: a meroterpene cyclic carbonate and related metabolites from the Australian fungus Aspergillus sp. CMB-MRF324

Wu, Taizong, Salim, Angela A. and Capon, Robert J. (2021). Millmerranones A–F: a meroterpene cyclic carbonate and related metabolites from the Australian fungus Aspergillus sp. CMB-MRF324. Organic Letters, 23 (21) acs.orglett.1c03150, 8424-8428. doi: 10.1021/acs.orglett.1c03150

Methods in microbial biodiscovery

Salim, Angela A., Khalil, Zeinab G., Elbanna, Ahmed H., Wu, Taizong and Capon, Robert J. (2021). Methods in microbial biodiscovery. Marine Drugs, 19 (9) 503. doi: 10.3390/md19090503

Chemical cues that attract cannibalistic cane toad (Rhinella marina) larvae to vulnerable embryos

Crossland, Michael R., Salim, Angela A., Capon, Robert J. and Shine, Richard (2021). Chemical cues that attract cannibalistic cane toad (Rhinella marina) larvae to vulnerable embryos. Scientific Reports, 11 (1) 12527, 12527. doi: 10.1038/s41598-021-90233-3

New from old: Thorectandrin alkaloids in a Southern Australian marine sponge, Thorectandra choanoides (CMB-01889)

Khushi, Shamsunnahar, Salim, Angela A., Elbanna, Ahmed H., Nahar, Laizuman and Capon, Robert J. (2021). New from old: Thorectandrin alkaloids in a Southern Australian marine sponge, Thorectandra choanoides (CMB-01889). Marine Drugs, 19 (2) 97, 1-10. doi: 10.3390/md19020097

Amaurones A–K: polyketides from the fish gut-derived Fungus Amauroascus sp. CMB-F713

Wu, Taizong, Salim, Angela A., Bernhardt, Paul V. and Capon, Robert J. (2021). Amaurones A–K: polyketides from the fish gut-derived Fungus Amauroascus sp. CMB-F713. Journal of Natural Products, 84 (2) acs.jnatprod.0c01343, 474-482. doi: 10.1021/acs.jnatprod.0c01343

Lincolnenins A–D: isomeric bactericidal bianthracenes from Streptomyces lincolnensis

Mohamed, Osama G., Khalil, Zeinab G., Salim, Angela A., Cui, Hui, Blumenthal, Antje and Capon, Robert J. (2020). Lincolnenins A–D: isomeric bactericidal bianthracenes from Streptomyces lincolnensis. The Journal of Organic Chemistry, 86 (16) acs.joc.0c02492, 11011-11018. doi: 10.1021/acs.joc.0c02492

Exploring natural product artifacts: the polyketide enterocin warms to a ballet of isomers

Salim, Angela A., Samarasekera, Kaumadi, Khalil, Zeinab G. and Capon, Robert J. (2020). Exploring natural product artifacts: the polyketide enterocin warms to a ballet of isomers. Organic Letters, 22 (12) acs.orglett.0c01629, 4828-4832. doi: 10.1021/acs.orglett.0c01629

Dysidealactams and dysidealactones: sesquiterpene glycinyl-lactams, imides, and lactones from a Dysidea sp. marine sponge collected in Southern Australia

Khushi, Shamsunnahar, Salim, Angela A., Elbanna, Ahmed H., Nahar, Laizuman, Bernhardt, Paul V. and Capon, Robert J. (2020). Dysidealactams and dysidealactones: sesquiterpene glycinyl-lactams, imides, and lactones from a Dysidea sp. marine sponge collected in Southern Australia. Journal of Natural Products, 83 (5) acs.jnatprod.0c00041, 1577-1584. doi: 10.1021/acs.jnatprod.0c00041

Chrysosporazines F–M: P-glycoprotein inhibitory phenylpropanoid piperazines from an Australian marine fish derived fungus, Chrysosporium sp. CMB-F294

Mohamed, Osama G., Salim, Angela A., Khalil, Zeinab G., Elbanna, Ahmed H., Bernhardt, Paul V. and Capon, Robert J. (2020). Chrysosporazines F–M: P-glycoprotein inhibitory phenylpropanoid piperazines from an Australian marine fish derived fungus, Chrysosporium sp. CMB-F294. Journal of Natural Products, 83 (2) acs.jnatprod.9b01181, 497-504. doi: 10.1021/acs.jnatprod.9b01181

Trachycladindoles H–M: molecular networking guided exploration of a library of southern Australian marine sponges

Khushi, Shamsunnahar, Nahar, Laizuman, Salim, Angela A. and Capon, Robert J. (2020). Trachycladindoles H–M: molecular networking guided exploration of a library of southern Australian marine sponges. Australian Journal of Chemistry, 73 (4), 338-343. doi: 10.1071/ch19567

Structure revision of the rare sponge metabolite echinosulfone A, and biosynthetically related echinosulfonic acids A–D

Neupane, Pratik, Salim, Angela A. and Capon, Robert J. (2020). Structure revision of the rare sponge metabolite echinosulfone A, and biosynthetically related echinosulfonic acids A–D. Tetrahedron Letters, 61 (12) 151651, 1-3. doi: 10.1016/j.tetlet.2020.151651

Trivirensols: selectively bacteriostatic sesquiterpene trimers from the Australian termite nest-derived fungus Trichoderma virens CMB-TN16

Jiao, Wei-Hua, Salim, Angela A., Khalil, Zeinab G., Dewapriya, Pradeep, Lin, Hou-Wen, Butler, Mark S. and Capon, Robert J. (2019). Trivirensols: selectively bacteriostatic sesquiterpene trimers from the Australian termite nest-derived fungus Trichoderma virens CMB-TN16. Journal of Natural Products, 82 (11), 3165-3175. doi: 10.1021/acs.jnatprod.9b00760

The effects of conspecific alarm cues on larval cane toads (Rhinella marina)

Crossland, Michael R., Salim, Angela A., Capon, Robert J. and Shine, Richard (2019). The effects of conspecific alarm cues on larval cane toads (Rhinella marina). Journal of Chemical Ecology, 45 (10), 838-848. doi: 10.1007/s10886-019-01111-2

Talarophenol sulfate and talarophilones from the Australian mud dauber wasp-associated fungus, Talaromyces sp. CMB-W045

Kalansuriya, Pabasara, Khalil, Zeinab G., Salim, Angela A. and Capon, Robert J. (2019). Talarophenol sulfate and talarophilones from the Australian mud dauber wasp-associated fungus, Talaromyces sp. CMB-W045. Tetrahedron Letters, 60 (43) 151157, 151157. doi: 10.1016/j.tetlet.2019.151157

Solvolysis artifacts: leucettazoles as cryptic macrocyclic alkaloid dimers from a Southern Australian marine sponge, Leucetta sp.

Prasad, Pritesh, Salim, Angela A., Khushi, Shamsunnahar, Khalil, Zeinab G., Quezada, Michelle and Capon, Robert J. (2019). Solvolysis artifacts: leucettazoles as cryptic macrocyclic alkaloid dimers from a Southern Australian marine sponge, Leucetta sp.. Marine Drugs, 17 (2) md17020106, 106. doi: 10.3390/md17020106

Bromocatechol conjugates from a Chinese marine red alga, Symphyocladia latiuscula

Xu, Xiuli, Yang, Haijin, Khalil, Zeinab G., Yin, Liyuan, Xiao, Xue, Salim, Angela A., Song, Fuhang and Capon, Robert J. (2019). Bromocatechol conjugates from a Chinese marine red alga, Symphyocladia latiuscula. Phytochemistry, 158, 20-25. doi: 10.1016/j.phytochem.2018.10.026

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

Atif, Mohammed, Smith, Jennifer J., Estrada-Mondragon, Argel, Xiao, Xue, Salim, Angela A., Capon, Robert J., Lynch, Joseph W. and Keramidas, Angelo (2019). GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance. PLOS Pathogens, 15 (1) e1007570, e1007570. doi: 10.1371/journal.ppat.1007570

Divirensols: Sesquiterpene Dimers from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16

Jiao, Wei-Hua, Dewapriya, Pradeep, Mohamed, Osama, Khalil, Zeinab G., Salim, Angela A., Lin, Hou-Wen and Capon, Robert J. (2018). Divirensols: Sesquiterpene Dimers from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16. Journal of Natural Products, 82 (1) acs.jnatprod.8b00746, 87-95. doi: 10.1021/acs.jnatprod.8b00746

Cacolides: sesterterpene butenolides from a Southern Australian marine sponge, Cacospongia sp.

Khushi, Shamsunnahar, Nahar, Laizuman, Salim, Angela and Capon, Robert (2018). Cacolides: sesterterpene butenolides from a Southern Australian marine sponge, Cacospongia sp.. Marine Drugs, 16 (11) 456, 456. doi: 10.3390/md16110456

Talaropeptides A-D: Structure and Biosynthesis of Extensively N-methylated Linear Peptides From an Australian Marine Tunicate-Derived Talaromyces sp

Dewapriya, Pradeep, Khalil, Zeinab G., Prasad, Pritesh, Salim, Angela A., Cruz-Morales, Pablo, Marcellin, Esteban and Capon, Robert J. (2018). Talaropeptides A-D: Structure and Biosynthesis of Extensively N-methylated Linear Peptides From an Australian Marine Tunicate-Derived Talaromyces sp. Frontiers in Chemistry, 6 394, 394. doi: 10.3389/fchem.2018.00394

Pursuing sesterterpene lactams in Australian Irciniidae sponges

Prasad, Pritesh, Zhang, Ailian, Salim, Angela A and Capon, Robert J (2018). Pursuing sesterterpene lactams in Australian Irciniidae sponges. Fitoterapia, 126, 83-89. doi: 10.1016/j.fitote.2017.09.003

Trichodermides A-E: New peptaibols isolated from the Australian termite nest-derived fungus trichoderma virens CMB-TN16

Jiao, Wei-Hua, Khalil, Zeinab, Dewapriya, Pradeep, Salim, Angela A, Lin, Hou-Wen and Capon, Robert J (2018). Trichodermides A-E: New peptaibols isolated from the Australian termite nest-derived fungus trichoderma virens CMB-TN16. Journal of Natural Products, 81 (4), 976-984. doi: 10.1021/acs.jnatprod.7b01072

Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula

Xu, Xiuli, Yang, Haijin, Khalil, Zeinab G, Yin, Liyuan, Xiao, Xue, Neupane, Pratik, Bernhardt, Paul V, Salim, Angela A, Song, Fuhang and Capon, Robert J (2017). Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula. Marine drugs, 15 (12) 374, 1-10. doi: 10.3390/md15120374

Diverse cone-snail species harbor closely related streptomyces species with conserved chemical and genetic profiles, including polycyclic tetramic acid macrolactams

Quezada, Michelle, Licona-Cassani, Cuauhtemoc, Cruz-Morales, Pablo, Salim, Angela A., Marcellin, Esteban, Capon, Robert J. and Barona-Gomez, Francisco (2017). Diverse cone-snail species harbor closely related streptomyces species with conserved chemical and genetic profiles, including polycyclic tetramic acid macrolactams. Frontiers in Microbiology, 8 (NOV) 2305, 2305. doi: 10.3389/fmicb.2017.02305

Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494

Khalil, Zeinab G., Salim, Angela A., Vuong, Daniel, Crombie, Andrew, Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2017). Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494. The Journal of Antibiotics, 70 (12), 1097-1103. doi: 10.1038/ja.2017.119

Cytochalasins from an Australian Marine Sediment-Derived Phomopsis sp. (CMB-M0042F): Acid-Mediated Intramolecular Cycloadditions Enhance Chemical Diversity

Shang, Zhuo, Raju, Ritesh, Salim, Angela A., Khalil, Zeinab G. and Capon, Robert J. (2017). Cytochalasins from an Australian Marine Sediment-Derived Phomopsis sp. (CMB-M0042F): Acid-Mediated Intramolecular Cycloadditions Enhance Chemical Diversity. Journal of Organic Chemistry, 82 (18), 9704-9709. doi: 10.1021/acs.joc.7b01793

Microbiome-mediated biotransformation of cane toad bufagenins

Kamalakkannan, Venkatanambi, Salim, Angela A. and Capon, Robert J. (2017). Microbiome-mediated biotransformation of cane toad bufagenins. Journal of Natural Products, 80 (7), 2012-2017. doi: 10.1021/acs.jnatprod.7b00134

Chaunopyran A: co-cultivation of marine mollusk-derived fungi activates a rare class of 2-alkenyl-tetrahydropyran

Shang, Zhuo, Salim, Angela A. and Capon, Robert J. (2017). Chaunopyran A: co-cultivation of marine mollusk-derived fungi activates a rare class of 2-alkenyl-tetrahydropyran. Journal of Natural Products, 80 (4), 1167-1172. doi: 10.1021/acs.jnatprod.7b00144

Waspergillamide A, a Nitro depsi-Tetrapeptide Diketopiperazine from an Australian Mud Dauber Wasp-Associated Aspergillus sp. (CMB-W031)

Quezada, Michelle, Shang, Zhuo, Kalansuriya, Pabasara, Salim, Angela A., Lacey, Ernest and Capon, Robert J. (2017). Waspergillamide A, a Nitro depsi-Tetrapeptide Diketopiperazine from an Australian Mud Dauber Wasp-Associated Aspergillus sp. (CMB-W031). Journal of Natural Products, 80 (4), 1192-1195. doi: 10.1021/acs.jnatprod.6b01062

Talarolide A, a cyclic heptapeptide hydroxamate from an Australian marine tunicate-associated fungus, Talaromyces sp. (CMB-TU011)

Dewapriya, Pradeep, Prasad, Pritesh, Damodar, Rakesh, Salim, Angela A. and Capon, Robert J. (2017). Talarolide A, a cyclic heptapeptide hydroxamate from an Australian marine tunicate-associated fungus, Talaromyces sp. (CMB-TU011). Organic Letters, 19 (8), 2046-2049. doi: 10.1021/acs.orglett.7b00638

Small-molecule inhibitors of the SOX18 transcription factor

Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017). Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 (3), 346-359. doi: 10.1016/j.chembiol.2017.01.003

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017). Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 e21221. doi: 10.7554/eLife.21221

AMPK and endothelial nitric oxide synthase signaling regulates K-Ras plasma membrane interactions via cyclic GMP-dependent protein kinase 2

Cho, Kwang-Jin, Casteel, Darren E., Prakash, Priyanka, Tan, Lingxiao, van der Hoeven, Dharini, Angela Salim, Kim, Choel, Capon, Robert J., Lacey, Ernest, Cunha, Shane R., Gorfe, Alemayehu A. and Hancock, John F. (2016). AMPK and endothelial nitric oxide synthase signaling regulates K-Ras plasma membrane interactions via cyclic GMP-dependent protein kinase 2. Molecular and Cellular Biology, 36 (24), 3086-3099. doi: 10.1128/MCB.00365-16

Roseopurpurins: chemical diversity enhanced by convergent biosynthesis and forward and reverse Michael additions

Shang, Zhuo, Khalil, Zeinab, Li, Li, Salim, Angela A., Quezada, Michelle, Kalansuriya, Pabasara and Capon, Robert J. (2016). Roseopurpurins: chemical diversity enhanced by convergent biosynthesis and forward and reverse Michael additions. Organic Letters, 18 (17), 4340-4343. doi: 10.1021/acs.orglett.6b02099

Fungal biotransformation of tetracycline antibiotics

Shang, Zhuo, Salim, Angela A., Khalil, Zeinab, Bernhardt, Paul V. and Capon, Robert J. (2016). Fungal biotransformation of tetracycline antibiotics. Journal of Organic Chemistry, 81 (15), 6186-6194. doi: 10.1021/acs.joc.6b01272

C3 and 2D C3 Marfey’s methods for amino acid analysis in natural products

Vijayasarathy, Soumini, Prasad, Pritesh, Fremlin, Leith J., Ratnayake, Ranjala, Salim, Angela A., Khalil, Zeinab and Capon, Robert J. (2016). C3 and 2D C3 Marfey’s methods for amino acid analysis in natural products. Journal of Natural Products, 79 (2), 421-427. doi: 10.1021/acs.jnatprod.5b01125

Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold

Shang, Zhuo, Salim, Angela A., Khalil, Zeinab, Quezada, Michelle, Bernhardt, Paul V. and Capon, Robert J. (2015). Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold. Journal of Organic Chemistry, 80 (24), 12501-12508. doi: 10.1021/acs.joc.5b02367

Oligomycins as inhibitors of K-Ras plasma membrane localisation

Salim, A. A., Tan, L., Huang, X. C., Cho, K. J., Lacey, E., Hancock, J. F. and Capon, R. J. (2015). Oligomycins as inhibitors of K-Ras plasma membrane localisation. Organic and Biomolecular Chemistry, 14 (2), 711-715. doi: 10.1039/c5ob02020d

New PKS-NRPS tetramic acids and pyridinone from an Australian marine-derived fungus, Chaunopycnis sp.

Shang, Zhuo, Li, Li, Esposito, Breno P., Salim, Angela A., Khalil, Zeinab G., Quezada, Michelle, Bernhardt, Paul V. and Capon, Robert J. (2015). New PKS-NRPS tetramic acids and pyridinone from an Australian marine-derived fungus, Chaunopycnis sp.. Organic and Biomolecular Chemistry, 13 (28), 7795-7802. doi: 10.1039/c5ob01058f

Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.

Khalil, Zeinab G., Raju, Ritesh, Piggott, Andrew M., Salim, Angela A., Blumenthal, Antje and Capon, Robert J. (2015). Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.. Journal of Natural Products, 78 (4), 949-952. doi: 10.1021/acs.jnatprod.5b00095

Isolation and synthesis of N-acyladenine and adenosine alkaloids from a southern Australian marine sponge, Phoriospongia sp.

Farrugia, Michelle, Trotter, Nicholas, Vijayasarathy, Soumini, Salim, Angele A., Khalil, Zeinab G., Lacey, Ernest and Capon, Robert J. (2014). Isolation and synthesis of N-acyladenine and adenosine alkaloids from a southern Australian marine sponge, Phoriospongia sp.. Tetrahedron Letters, 55 (43), 5902-5904. doi: 10.1016/j.tetlet.2014.08.116

Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras

Salim, Angela A., Cho, Kwang-Jin, Tan, Lingxiao, Quezada, Michelle, Lacey, Ernest, Hancock, John F. and Capon, Robert J. (2014). Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras. Organic Letters, 16 (19), 5036-5039. doi: 10.1021/ol502376e

Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces

Khalil, Zeinab G., Salim, Angela A., Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2014). Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. Organic Letters, 16 (19), 5120-5123. doi: 10.1021/ol502472c

Rare Streptomyces sp. polyketides as modulators of K-Ras localisation

Salim, Angela A., Xiao, Xue, Cho, Kwang-Jin, Piggott, Andrew M., Lacey, Ernest, Hancock, John F. and Capon, Robert J. (2014). Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Organic and Biomolecular Chemistry, 12 (27), 4872-4878. doi: 10.1039/c4ob00745j

Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells

Huang, Xiao-Cong, Xiao, Xue, Zhang, Yun-Kai, Talele, Tanaji T., Salim, Angela A., Chen, Zhe-Sheng and Capon, Robert J. (2014). Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells. Marine Drugs, 12 (7), 3818-3837. doi: 10.3390/md12073818

Parguerenes: marine red alga bromoditerpenes as inhibitors of P-glycoprotein (ABCB1) in multidrug resistant human cancer cells

Huang, Xiao-cong, Sun, Yue-Li, Salim, Angela A., Chen, Zhe-Sheng and Capon, Robert J. (2013). Parguerenes: marine red alga bromoditerpenes as inhibitors of P-glycoprotein (ABCB1) in multidrug resistant human cancer cells. Biochemical Pharmacology, 85 (9), 1257-1268. doi: 10.1016/j.bcp.2013.02.005

Dual inhibition of DNA polymerase PolC and protein tyrosine phosphatase CpsB uncovers a novel antibiotic target

Standish, Alistair J., Salim, Angela A., Capon, Robert J. and Morona, Renato (2013). Dual inhibition of DNA polymerase PolC and protein tyrosine phosphatase CpsB uncovers a novel antibiotic target. Biochemical and Biophysical Research Communications, 430 (1), 167-172. doi: 10.1016/j.bbrc.2012.11.049

Staurosporines disrupt phosphatidylserine trafficking and mislocalize ras proteins

Cho, Kwang-jin, Park, Jin-Hee, Piggott, Andrew M., Salim, Angela A., Gorfe, Alemaheyu A., Parton, Robert G., Capon, Robert J., Lacey, Ernest and Hancock, John F. (2012). Staurosporines disrupt phosphatidylserine trafficking and mislocalize ras proteins. Journal of Biological Chemistry, 287 (52), 43573-43584. doi: 10.1074/jbc.M112.424457

Structural and stereochemical investigations into bromotyrosine-derived metabolites from southern Australian marine sponges, Pseudoceratina spp.

Salim, Angela A., Khalil, Zeinab G. and Capon, Robert J. (2012). Structural and stereochemical investigations into bromotyrosine-derived metabolites from southern Australian marine sponges, Pseudoceratina spp.. Tetrahedron, 68 (47), 9802-9807. doi: 10.1016/j.tet.2012.09.008

Exploiting intraspecific competitive mechanisms to control invasive cane toads (Rhinella marina)

Crossland, Michael R., Haramura, Takashi, Salim, Angela A., Capon, Robert J. and Shine, Richard (2012). Exploiting intraspecific competitive mechanisms to control invasive cane toads (Rhinella marina). Proceedings of the Royal Society B-Biological Sciences, 279 (1742), 3436-3442. doi: 10.1098/rspb.2012.0821

Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production

Standish, Alistair J., Salim, Angela A., Zhang, Hua, Capon, Robert J. and Morona, Renato (2012). Chemical inhibition of bacterial protein tyrosine phosphatase suppresses capsule production. Plos One, 7 (5) e36312, e36312.1-e36312.8. doi: 10.1371/journal.pone.0036312

High-throughput screening of Australian marine organism extracts for bioactive molecules affecting the cellular storage of neutral lipids

Rae, James, Fontaine, Frank, Salim, Angela A., Lo, Harriet P., Capon, Robert J., Parton, Robert G. and Martin, Sally (2011). High-throughput screening of Australian marine organism extracts for bioactive molecules affecting the cellular storage of neutral lipids. PLoS One, 6 (8) e22868, e22868.1-e22868.13. doi: 10.1371/journal.pone.0022868

Heterofibrins: Inhibitors of lipid droplet formation from a deep-water southern Australian marine sponge, Spongia (Heterofibria) sp.

Salim, Angela A., Rae, James, Fontaine, Frank, Conte, Melissa M., Khalil, Zeinab, Martin, Sally, Parton, Robert G. and Capon, Robert J. (2010). Heterofibrins: Inhibitors of lipid droplet formation from a deep-water southern Australian marine sponge, Spongia (Heterofibria) sp.. Organic and Biomolecular Chemistry, 8 (14), 3188-3194. doi: 10.1039/c003840g

New oxygenated diterpenes from an Australian nudibranch of the genus Chromodoris

Yong, Ken W. L., Salim, Angela A. and Garson, Mary J. (2008). New oxygenated diterpenes from an Australian nudibranch of the genus Chromodoris. Tetrahedron, 2008 (64), 6733-6738. doi: 10.1016/j.tet.2008.05.008

Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry)

Tomosaka, Hideyuki, Chin, Young-Won, Salim, Angela A., Keller, William J., Chai, Heebyung and Kinghorn, A. Douglas (2008). Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry). Phytotherapy Research, 22 (7), 979-981. doi: 10.1002/ptr.2443

Biotransformation of mefenamic acid by cell suspension cultures of Solanum mammosum

Surodjo, S., Salim, A. ., Suciati, Syahrani, A., Indrayanto, G. and Garson, M.J. (2008). Biotransformation of mefenamic acid by cell suspension cultures of Solanum mammosum. Natural Product Communications, 3 (2), 257-262. doi: 10.1177/1934578x0800300231

Potential anticancer activity of naturally occurring and semi-synthetic derivatives of aculeatins A and B from Amomum aculeatumatum

Chin, Young-Won, Salim, Angela A., Su, Bao-Ning, Mi, Qiuwen, Chai, Hee-Byung, Riswan, Soedarsono, Kardono, Leonardus B. S., Ruskandi, Agus, Farnsworth, Norman R., Swanson, Steven M. and Kinghorn, A. Douglas (2008). Potential anticancer activity of naturally occurring and semi-synthetic derivatives of aculeatins A and B from Amomum aculeatumatum. Journal of Natural Products, 71 (3), 390-395. doi: 10.1021/np070584j

Constituents of the leaves and stem bark of Aglaia foveolata

Salim, Angela A., Chai, Hee-Byung, Rachman, Ismail, Riswan, Soedarsono, Kardono, Leonardus B.S., Farnsworth, Norman R., Carcache-Blanco, Esperanza J. and Kinghorn, A. Douglas (2007). Constituents of the leaves and stem bark of Aglaia foveolata. Tetrahedron, 63 (33), 7926-7934. doi: 10.1016/j.tet.2007.05.074

Dioxadispiroketal compounds and a potential acyclic precursor from Amomum aculeatum

Salim, Angela A., Sua, Bao-Ning, Chaia, Hee-Byung, Riswanb, Soedarsono, Kardonoc, Leonardus B. S., Ruskandib, Agus, Farnsworthd, Norman R., Swansond, Steven M. and Kinghorna, A. Douglas (2007). Dioxadispiroketal compounds and a potential acyclic precursor from Amomum aculeatum. Tetrahedron letters, 48 (10), 1849-1853. doi: 10.1016/j.tetlet.2007.01.017

Ponapensin, a cyclopenta(bc)benzopyran with potent NF-kB inhibitory activity from Aglaia ponapensis

Salim, Angela A., Pawlus, Alison D., Chai, Hee-Byung, Farnsworth, Norman R., Kinghorn, A. Douglas and Carcache-Blanco, Esperanza J. (2007). Ponapensin, a cyclopenta(bc)benzopyran with potent NF-kB inhibitory activity from Aglaia ponapensis. Bioorganic & Medicinal Chemistry Letters, 17 (1), 109-112. doi: 10.1016/j.bmcl.2006.09.084

Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy

Kim, Soyoung, Salim, Angela A., Swanson, Steven M. and Douglas Kinghorn, A. (2006). Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 6 (4), 319-345. doi: 10.2174/187152006777698123

New Indole Alkaloids from the bark of Alstonia scholaris

Salim, Angela A., Garson, Mary J. and Craik, David J. (2004). New Indole Alkaloids from the bark of Alstonia scholaris. Journal of Natural Products, 67 (9), 1591-1594. doi: 10.1021/np0498612

New alkaloids from Pandanus amaryllifolius

Salim, Angela A., Garson, Mary J. and Craik, David J. (2004). New alkaloids from Pandanus amaryllifolius. Journal of Natural Products, 67 (1), 54-57. doi: 10.1021/np0303310

New indole alkaloids from the roots of Ochrosia acuminata

Salim, A. A., Garson, M. J. and Craik, D. J. (2004). New indole alkaloids from the roots of Ochrosia acuminata. Journal of Natural Products, 67 (10), 1719-1721. doi: 10.1021/np049812p

Structure and function of plant toxins (with emphasis on cystine knot toxins)

Craik, D. J., Daly, N. L., Plan, M. R., Salim, A. A. and Sando, L. (2002). Structure and function of plant toxins (with emphasis on cystine knot toxins). Journal of Toxicology-toxin Reviews, 21 (3), 229-271. doi: 10.1081/TXR-120014405

Investigating the role of bioactives produced by gut bacteria to modulate immune response in inflammatory bowel disease

Giri, R., Shamsunnahar, K., Salim, A., Capon, R., Morrison, M., Cuiv, P. O. and Begun, J. (2020). Investigating the role of bioactives produced by gut bacteria to modulate immune response in inflammatory bowel disease. 15th Congress of ECCO, Vienna, Austria, 12-15 February 2020. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjz203.035

Talaropeptides A–D: Structure and biosynthesis of extensively N-methylated linear peptides from an Australian marine tunicate-derived Talaromyces sp.

Dewapriya, Pradeep, Khalil, Zeinab G., Prasad, Pritesh, Salim, Angela A., Morales, Pablo C., Marcellin, Esteban and Capon, Robert J. (2018). Talaropeptides A–D: Structure and biosynthesis of extensively N-methylated linear peptides from an Australian marine tunicate-derived Talaromyces sp.. American Society of Pharmacognosy Annual Meeting ASP 2018, Lexington, KY United States, 21-25 July 2018.

Talarolide A, a cyclic heptapeptide hydroxamate from an Australian marine tunicate-associated fungus, Talaromyces sp.

Dewapriya, Pradeep, Prasad, Pritesh, Damodar, Rakesh, Salim, Angela A. and Capon, Robert J. (2017). Talarolide A, a cyclic heptapeptide hydroxamate from an Australian marine tunicate-associated fungus, Talaromyces sp.. 2nd International Conference of Marine Fungal Natural Products, Kiel, Germany, 27-29 June 2017.

Viridicatumtoxins: Exploring structural diversity and antibiotic properties

Shang, Z., Salim, A. A., Khalil, Z. G., Quezada, M., Bernhardt, P. V. and Capon, R. J. (2015). Viridicatumtoxins: Exploring structural diversity and antibiotic properties. Annual Meeting of the American-Society-of-Pharmacognosy, Copper Mountain, CO, United States, 25-29 July 2015. Stuttgart, Germany: Georg Thieme. doi: 10.1055/s-0035-1556338

Chemical studies on Indonesian medicinal plants

Garson, M.J., Salim, A.A., . Rudiyansyah, Suciati and Ross, B.P. (2008). Chemical studies on Indonesian medicinal plants. International Organization for Chemical Sciences in Development Meeting, Botswana, February, 2008.

The plant-derived agent silvestrol has B-Cell selective activity in vitro in chronic lymphocytic leukemia patient cells and in vivo in the Tcl-1 mouse model of CLL

Lucas, David M., Edwards, Ryan B., De lay, Michael D., West, Derek A., Lozanski, Gerard, Johnson, Amy J., Salim, Angela A., Lin, Thomas S., Byrd, John C., Kinghorn, A. Douglas and Grever, Michael R. (2007). The plant-derived agent silvestrol has B-Cell selective activity in vitro in chronic lymphocytic leukemia patient cells and in vivo in the Tcl-1 mouse model of CLL. 49th Annual Meeting of the American-Society-of-Hematology, Atlanta, GA United States, 8-11 December 2007. Washington, DC United States: American Society of Hematology.

AGFD 132-Antioxidants from Berberis vulgaris (Barberry)

Tomosaka, Hideyuki, Chai, Heebyung, Chin, Young-Won, Salim, Angela A., Keller, William J. and Kinghorn, A. Douglas (2007). AGFD 132-Antioxidants from Berberis vulgaris (Barberry). WASHINGTON: AMER CHEMICAL SOC.

The Plant-Derived Agent Silvestrol Has B-Cell Selective Activity In Vitro in Chronic Lymphocytic Leukemia Patient Cells and In Vivo in the Tcl-1 Mouse Model of CLL Blood (ASH Annual Meeting Abstracts) 2007 110: Abstract 3123

Lucas, David M., Edwards, Ryan B., De Lay, Michael D., West, Derek A., Lozanski, Gerard, Johnson, Amy J., Salim, Angela A., Lin, Thomas S., Byrd, John C., Kinghorn, A. Douglas and Grever, Michael R. (2007). The Plant-Derived Agent Silvestrol Has B-Cell Selective Activity In Vitro in Chronic Lymphocytic Leukemia Patient Cells and In Vivo in the Tcl-1 Mouse Model of CLL Blood (ASH Annual Meeting Abstracts) 2007 110: Abstract 3123. 49th ASH Annual Meeting: Blood (ASH Annual Meeting Abstracts), Georgia World Congress Center, Atlanta, Georgia, 8-11 December 2007. American Society of Hematology.

Chemical diversity and Indonesian medicinal plants

Garson, M J, Rudiyansyah, .., Salim, A. and Craik, D J (2006). Chemical diversity and Indonesian medicinal plants. 21st Philippino Chemical Congress, Davao, 4-7 April, 2006.

Novel bioactive alkaloids from Ochrosia acuminata and Alstonia scholaris

Salim, A., Garson, M. J. and Craik, D. J. (2004). Novel bioactive alkaloids from Ochrosia acuminata and Alstonia scholaris. SimNasKBA-2004, Bandung, Dec, 2004.

Novel bioactive alkaloids from Ochrosia acuminate and Alstonia scholaris

Salim, A., Garson, M. J. and Craik, D. J. (2004). Novel bioactive alkaloids from Ochrosia acuminate and Alstonia scholaris. American Society of Pharmacognosy Annual Meeting, Phoenix, July, 2004.

Novel bioalkaloids from Ochrosia acuminate and Alstonia scholaris

Salim, A., Garson, M. J. and Craik, D. J. (2004). Novel bioalkaloids from Ochrosia acuminate and Alstonia scholaris. ANZMAG 2004, Adelaide, 15-20 Feb, 2004.

Novel bioactive alkaloids from Alstonia scholaris bark

Salim, A., Garson, M. J. and Craik, D. J. (2003). Novel bioactive alkaloids from Alstonia scholaris bark. BBOCS: Brisbane Biological and Organic Chemistry Symposium 2003, Brisbane, 28 November 2003.

Novel bioactive alkaloids from Ochrosia acuminata root

Salim, A., Garson, M. J. and Craik, D. J. (2003). Novel bioactive alkaloids from Ochrosia acuminata root. BBOCS: Brisbane Biological and Organic Chemistry Symposium 2003, Brisbane, 28 November 2003.

Novel bioactive alkaloids from Ochrosia acuminata root

Salim, A., Garson, M. J. and Craik, D. J. (2003). Novel bioactive alkaloids from Ochrosia acuminata root. XI Asian Symposium on Medicinal Plants, Spices and Other Natural Products, Kunming, China, 26-30 October, 2003.

Novel bioactive alkaloids from Ochrosia acuminata root

Salim, A., Garson, M. J. and Craik, D. J. (2003). Novel bioactive alkaloids from Ochrosia acuminata root. RACI National Organic Chemistry Conference, Lorne, Victoria, July, 2003.

Novel Bioactive alkaloids from Pandanus amaryllifolius from West Timor

Salim, A., Garson, M. J. and Craik, D. J. (2002). Novel Bioactive alkaloids from Pandanus amaryllifolius from West Timor. 23rd International Conference on Natural Products, Italy, July, 2002.

Novel Bioactive alkaloids from a Pandanus amaryllifolius from West Timor

Salim, A., Garson, M. J. and Craik, D. J. (2002). Novel Bioactive alkaloids from a Pandanus amaryllifolius from West Timor. Brisbane Biological & Organic Chemistry Symposium, Brisbane, November, 2002.