Dr Jacky Suen

Senior Research Fellow

Institute for Molecular Bioscience
j.suen1@uq.edu.au
+61 7 3139 5151

Overview

Critical Care Medicine focuses on supporting patients, often with one or multiple organ failures. Based at the largest Australian cardiac hospital, our research investigates better ways to support patients with heart and/or lung failure. We explore technological, pharmacological and engineering advances that could help our patients to live longer and better. Our group is world-renowned for clinically relevant large animal models, including heart failure, respiratory failure (ARDS), heart transplantation, sepsis, cardiogenic shock, and more. All our studies use hospital-grade equipment and follow the same clinical guideline to maximise translation. We actively take on honours, MPhil and PhD students from multi-disciplinary backgrounds (science, engineering, medicine, allied health), with a successful track record in supporting our students to secure their own grants and funding. Students are expected to contribute to other studies of the group. For more information about the group, please visit ccrg.org.au, and email if you are interested to join us.

Qualifications

  • Member, Extracorporeal Life Support Organization, Extracorporeal Life Support Organization
  • Doctor of Philosophy of Pharmacology, The University of Queensland
  • Bachelor (Honours) of Science (Advanced), The University of Queensland

Publications

  • Urner, Martin, Barnett, Adrian G., Bassi, Gianluigi Li, Brodie, Daniel, Dalton, Heidi J., Ferguson, Niall D., Heinsar, Silver, Hodgson, Carol L., Peek, Giles, Shekar, Kiran, Suen, Jacky Y., Fraser, John F., Fan, Eddy, COVID-19 Critical Care Consortium Investigators and Obonyo, Nchafatso (2022). Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study. BMJ, 377 e068723, e068723. doi: 10.1136/bmj-2021-068723

  • Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xiao, Di, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E. ... Palpant, Nathan J. (2021). Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury. Circulation, 144 (12), 947-960. doi: 10.1161/circulationaha.121.054360

  • Li Bassi, Gianluigi, Suen, Jacky Y, Dalton, Heidi J, White, Nicole, Shrapnel, Sally, Fanning, Jonathon P, Liquet, Benoit, Hinton, Samuel, Vuorinen, Aapeli, Booth, Gareth, Millar, Jonathan E, Forsyth, Simon, Panigada, Mauro, Laffey, John, Brodie, Daniel, Fan, Eddy, Torres, Antoni, Chiumello, Davide, Corley, Amanda, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Ng, Pauline Yeung, Ogino, Mark, Pesenti, Antonio, Trieu, Huynh Trung ... Obonyo, Gikenyi N. (2021). An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients. Critical Care, 25 (1) 199, 1-22. doi: 10.1186/s13054-021-03518-4

  • Millar, Jonathan E., Bartnikowski, Nicole, Passmore, Margaret R., Obonyo, Nchafatso G, Malfertheiner, Maximillian V., von Bahr, Viktor, Redd, Meredith A., See Hoe, Louise, Ki, Katrina K., Pedersen, Sanne, Boyle, Andrew J., Baillie, J Kenneth, Shekar, Kiran, Palpant, Nathan, Suen, Jacky Y., Matthay, Michael A., McAuley, Daniel F., Fraser, John F. and Combining Extracorporeal Life Support and Cell Therapy in Critical Illness (CELTIC) investigators (2020). Combined mesenchymal stromal cell therapy and ECMO in ARDS: a controlled experimental study in sheep. American Journal of Respiratory and Critical Care Medicine, 202 (3) rccm.201911-2143OC, 383-392. doi: 10.1164/rccm.201911-2143oc

  • Ki, Katrina K., Passmore, Margaret R., Chan, Chris H. H., Malfertheiner, Maximilian V., Fanning, Jonathon P., Bouquet, Mahé, Millar, Jonathan E., Fraser, John F. and Suen, Jacky Y. (2019). Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit. Intensive Care Medicine Experimental, 7 (1) 51, 51. doi: 10.1186/s40635-019-0264-z

View all Publications

Supervision

View all Supervision

Available Projects

  • We are looking for honours students to be involved in our range of studies on cardiac/respiratory failure. Projects include heart transplantation, acute respiratory failure, sepsis and advanced life support. Students will be expected and supported for grant application, as most of our previous honours students were awarded with $10,000 New Investigator Grant.

  • We are looking for Honours and RHD students to be involved in our NHMRC-funded heart transplantation program. Previously, we have successfully translated our research on extended organ preservation to clinical practice in Australia/New Zealand. As we explore on a new donor source, we are looking for talented students to join the team to study mitochondrial dysfunction, as a key parameter in determining post-transplant cardiac function.

  • Extra-Corporeal Membrane Oxygenation (ECMO) is an artificial heart/lung machine that is use to support patients with severe cardiac/respiratory failure. It has been invented for more than 30 years. To date, there is a lack of systematic examination of various parameters and settings for ECMO. Many of the current clinical practise are based on convention and tradition. This project aims to research and provide empirical evidences in order to optimise ECMO usage for patients, leading to improved patient outcome and reduced length of hospital stay. The project could involve bench-top ex vivo experiments, large animal in vivo study, and, perspective and retrospective analysis of clinical studies.

View all Available Projects

Publications

Featured Publications

  • Urner, Martin, Barnett, Adrian G., Bassi, Gianluigi Li, Brodie, Daniel, Dalton, Heidi J., Ferguson, Niall D., Heinsar, Silver, Hodgson, Carol L., Peek, Giles, Shekar, Kiran, Suen, Jacky Y., Fraser, John F., Fan, Eddy, COVID-19 Critical Care Consortium Investigators and Obonyo, Nchafatso (2022). Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study. BMJ, 377 e068723, e068723. doi: 10.1136/bmj-2021-068723

  • Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xiao, Di, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E. ... Palpant, Nathan J. (2021). Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury. Circulation, 144 (12), 947-960. doi: 10.1161/circulationaha.121.054360

  • Li Bassi, Gianluigi, Suen, Jacky Y, Dalton, Heidi J, White, Nicole, Shrapnel, Sally, Fanning, Jonathon P, Liquet, Benoit, Hinton, Samuel, Vuorinen, Aapeli, Booth, Gareth, Millar, Jonathan E, Forsyth, Simon, Panigada, Mauro, Laffey, John, Brodie, Daniel, Fan, Eddy, Torres, Antoni, Chiumello, Davide, Corley, Amanda, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Ng, Pauline Yeung, Ogino, Mark, Pesenti, Antonio, Trieu, Huynh Trung ... Obonyo, Gikenyi N. (2021). An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients. Critical Care, 25 (1) 199, 1-22. doi: 10.1186/s13054-021-03518-4

  • Millar, Jonathan E., Bartnikowski, Nicole, Passmore, Margaret R., Obonyo, Nchafatso G, Malfertheiner, Maximillian V., von Bahr, Viktor, Redd, Meredith A., See Hoe, Louise, Ki, Katrina K., Pedersen, Sanne, Boyle, Andrew J., Baillie, J Kenneth, Shekar, Kiran, Palpant, Nathan, Suen, Jacky Y., Matthay, Michael A., McAuley, Daniel F., Fraser, John F. and Combining Extracorporeal Life Support and Cell Therapy in Critical Illness (CELTIC) investigators (2020). Combined mesenchymal stromal cell therapy and ECMO in ARDS: a controlled experimental study in sheep. American Journal of Respiratory and Critical Care Medicine, 202 (3) rccm.201911-2143OC, 383-392. doi: 10.1164/rccm.201911-2143oc

  • Ki, Katrina K., Passmore, Margaret R., Chan, Chris H. H., Malfertheiner, Maximilian V., Fanning, Jonathon P., Bouquet, Mahé, Millar, Jonathan E., Fraser, John F. and Suen, Jacky Y. (2019). Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit. Intensive Care Medicine Experimental, 7 (1) 51, 51. doi: 10.1186/s40635-019-0264-z

Journal Article

Conference Publication

  • Sato, K., Heinsar, S., Obonyo, N., Wildi, K., Liu, K., Farah, S., Ainola, C., Sato, N., Ijuin, S., Ro, S. Kyun, Fior, G., Gandini, L., Bouquet, M., Wilson, E., Passmore, M., Hyslop, K., Chan, J., Platts, D., Scalia, G., Suen, J., Bassi, G. Li and Fraser, J. (2023). A novel speckle-tracking echocardiographic parameter assessing left ventricular loading during VA ECMO in a pre-clinical model of cardiogenic shock. 71st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Adelaide, SA Australia, 3-6 August 2023. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2023.06.562

  • Palmieri, C., See Hoe, L., Dyer, W., Heinsar, S., Rozencwaig, S., Tung, J.P., Bartnikowski, N., Passmore, M., Bouquet, M., Hislop, K., Wilson, E., Li Bassi, g., Mcgiffin, D., Suen, J. and Fraser, J. (2023). Proposal of a reliable scoring system for the histological assessment of multiorgan injury in large animal models of ischaemia and shock. 2022 Annual Congress of the European Society of Veterinary Pathology and European College of Veterinary Pathologists, Athens, Greece, 7 - 10 September 2022. London, United Kingdom: Elsevier. doi: 10.1016/j.jcpa.2023.03.059

  • Sato, Kei, Heinsar, Silver, Wildi, Karin Susanne, Obonyo, Nchafatso, Liu, Keibun, Farah, Samia, Ainola, Carmen, Sato, Noriko, Fior, Gabriele, Ro, Sun Kyun, Gandini, Lucia, Ijuin, Shinichi, Bouquet, Mahe, Wilson, Emily, Passmore, Margaret, Hyslop, Kieran, Chan, Jonathan H., Platts, David, Suen, Jacky, Li Bassi, Gianluigi and Fraser, John (2023). A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO. 72nd Annual Scientific Session (ACC), New Orleans, LA, United States, 4-6 March 2023. San Diego, CA, United States: Elsevier.

  • Zhang, Chengda, Zakhary, Bishoy, White, Nicole, Heinsar, Silver, Burrell, Aidan, Zaaqoq, Akram, Jacobs, Jeffrey, Dalton, Heidi, Labib, Ahmed, Suen, Jacky, Mariani, Silvia, Bassi, Gianluigi Li, Fraser, John and Peek, Giles (2023). LENGTH OF PRE-ECMO MECHANICAL VENTILATION IS NOT ASSOCIATED WITH MORTALITY IN PATIENTS WITH COVID-19. 52nd Critical Care Congress of the Society-of-Critical-Care-Medicine (SCCM), San Francisco Ca, Jan 21-24, 2023. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.

  • Fanning, Jonathon, Huth, Samuel, Cho, Sung-Min, Robba, Chiara, Highton, David, Battaglini, Denise, Bellapart-Rubio, Judith, Suen, Jacky, Bassi, Gianluigi Li, Taccone, Fabio, Arora, Rakesh, Whitman, Glenn and Fraser, John (2021). Neurological manifestations of coronavirus disease 2019: a comprehensive review. ANZAN Annual Scientific Meeting 2021, February 2021, 20-21 November 2021. London, United Kingdom: BMJ Group. doi: 10.1136/bmjno-2021-anzan.1

  • Hoe, L. E. See, Wildi, K., Skeggs, K., Bouquet, M., Sato, K., Jung, J., Ainola, C., Hyslop, K., Heinsar, S., Abbate, G., Colombo, S. M., Passmore, M., Wood, E. S., Wells, M., Bartnikowski, N., O'Neill, H., Reid, J., Shuker, T., Haymet, A., Livingstone, S., Sato, N., Obonyo, N., James, L., He, T., McDonald, C., Mullins, D., Engkilde-Pedersen, S., Diab, S., Millar, J. E. ... Fraser, J. F. (2021). Donor heart preservation by hypothermic ex vivo perfusion - improved recipient survival and successful prolongation of ischemic time. Philadelphia, PA, United States: Elsevier.

  • Wells, Matthew, Molenaar, Peter, Hoe, Louise See, Obonyo, Nchafatso, James, Lynette, Bouquet, Mahe, Bartnikowski, Nicole, Passmore, Margaret, Boone, Connie, Wilde, Karin, Weilan, Mo, Hyslop, Kieran, McDonald, Charles, Pedersen, Sanne, Suen, Jacky, Peart, Jason, McGiffin, David and Fraser, John (2020). (-)-Noradrenaline sensitivity, contractility and mitochondrial function in an ovine model of brain stem death and transplantation. 2019 ISHR World Congress, Beijing, China, 3-6 June 2019. London, United Kingdom: Academic Press. doi: 10.1016/j.yjmcc.2019.11.114

  • Wells, Matthew, Seehoe, Louise, Zechovic, Olivia, Nchafatso, Obonyo, Bouquet, Mahe, Hyslop, Keiran, Black, Deborah, McDonald, Charles, Pedersen, Sanne, Suen, Jacky, Peart, Jason, McGiffin, David, Fraser, John and Lye, India (2020). Donor brain stem death and cardiac transplantation causes mitochondrial dyscoupling and oxidative stress. World Congress of Intensive Care, Melbourne, VIC Australia, 14-18 October 2019. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.aucc.2020.04.098

  • See Hoe, L., McGiffin, D., Wildi, K., Obonyo, N., Bouquet, M., Wells, M., Skeggs, K., McDonald, C., Engkilde-Pedersen, S., Bartnikowski, N., Colombo, S., Ainola, C., Passmore, M., Hyslop, K., Wood, E., Shuker, T., Sato, K., Jung, J., Heinser, S., James, L., Reid, J., O'Neill, H., Livingstone, S., Abbate, G., He, P., Sato, N., Boon, C., Black, D., Haymet, A. ... Fraser, J. (2020). Hypothermic ex vivo perfusion of brain dead donor hearts improves survival, systemic inflammation and cardiac function following heart transplantation. 8th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 14th Annual Australia and New Zealand Endovascular Therapies Meeting, Online, 11-13 December 2020. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2020.09.127

  • Sato, K., See Hoe, L., Obonyo, N., Wildi, K., Colombo, S., Bouquet, M., Passmore, M., Bartnikowski, N., Wells, M., Skeggs, K., McDonald, C., Hyslop, K., Wood, E., Heinser, S., Ainola, C., Jung, J., James, L., Abbate, G., Haymet, A., Engkilde-Pedersen, S., Reid, J., O'Neill, H., Shuker, T., He, P., Sato, N., Diab, S., Mullins, D., Livingstone, S., Wang, X. ... Fraser, J. (2020). Hypothermic ex vivo perfusion preserves post-transplant donor cardiac function. 8th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 14th Annual Australia and New Zealand Endovascular Therapies Meeting, Virtual, 11-13 December 2020. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2020.09.128

  • Hoe, L. E. See, Wells, M. A., Bouquet, M., Hyslop, K., Passmore, M. R., Bartnikowski, N., Obonyo, N. G., Reid, J., O'Neill, H., Shuker, T., McDonald, C., Engkilde-Pedersen, S., Wildi, K., Ainola, C., Skeggs, K., Jung, J., Colombo, S., Sato, K., James, L., He, P., Wood, E. S., Heinser, S., Wang, X., Abbate, G., Livingstone, S., Haymet, A., Walweel, K., Mullins, D., Marasco, S. ... Fraser, J. F. (2020). Metabolic and mitochondrial alterations following brain death and heart transplantation. 40th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Montreal, Canada, 22-25 April 2020. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2020.01.419

  • Li Bassi, G. , Colombo, S., Heinsar, S., Wildi, K., Ainola, C., Jung, J., Abbate, G., Hoe, L. See, Sato, K., Wang, X., Skeggs, K., Livingstone, S., Boquet, M., Passmore, M., Sato, N., Reid, J., James, L., Wilson, E., McGiffin, D., Suen, J. and Fraser, J. (2020). The Effects of Different Ventilatory Strategies on Pulmonary Mechanics and Gas Exchange During Heart Transplant: An Experimental Study. International Conference of the American Thoracic Society, Online, 2020. New York, NY United States: American Thoracic Society.

  • Hoe, L. See, Shuker, T., Bartnikowski, N., Passmore, M., Bouquet, M., Obonyo, N., Engkilde-Pedersen, S., McDonald, C., Wells, M., Boon, A., Hyslop, K., James, L., Wildi, K., Cullen, L., Bassi, G. Li, Suen, J., McGiffin, D. and Fraser, J. (2019). Characterisation of cardiac neurohormonal and inflammatory changes induced by brain death in a novel ovine heart transplant model. 67th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 13th Annual Australia and New Zealand Endovascular Therapies Meeting, Adelaide, Australia, 8-11 August 2019. chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2019.06.074

  • Fanning, Jonathon P., Obonyo, Nchafatso G., Tung, John-Paul, Byrne, Liam, Simonova, Gabriela, Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai-Ching, See Hoe, Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Hashairi Fauzi, Mohd, Pretti Pimenta, Leticia, Millar, Jonathan, Anstey, Christopher, van Haren, Frank, Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John (2018). Packed Red Cell Age Associated With Adverse Cardiovascular Changes in an Ovine Model of Septic Shock Resuscitation. American Heart Association's 2018 Scientific Sessions, Chicago, IL United States, 10-12 November 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1161/circ.138.suppl_1.17116

  • Bartnikowski, N., Obonyo, N., Pedersen, S., Wells, M., Millar, J., Raffel, O., Suen, J., Gregory, S., Haqqani, H. and Fraser, J. (2018). Development of an ovine model of dilated cardiomyopathy to facilitate clinically translational research. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, QLD Australia, 2 - 5 August 2018. Chatswood, NSW Australia: Elsevier . doi: 10.1016/j.hlc.2018.06.110

  • See Hoe, L., Engkilde-Pedersen, S., Obonyo, N., Wells, M., Boon, C., Bartnikowski, N., Passmore, M., McDonald, C., Black, D., Molenaar, P., Diab, S., Suen, J., Marasco, S., McGiffin, D. and Fraser, J. (2018). Development of an ovine model of heart transplantation following 24-hour brain stem death. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, Australia, 2-5 August 2018. Chatswood, NSW, Australia: Elsevier . doi: 10.1016/j.hlc.2018.06.111

  • Boon, A. C., Hoe, L. E. See, Pederson, S. E., Obonyo, N. G., Wells, M. A., Bartnikowski, N. J., Passmore, M. R., Marshall, L., James, L., Tung, J., Suen, J. Y., Macdonald, P. S., McGiffin, D. C. and Fraser, J. F. (2018). Inflammatory cytokine profiles in 24-hour brain stem death model. 38th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation (ISHLT), Nice, France, 11-14 April 2018. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.healun.2018.01.506

  • Fanning, Jonathon P., Hoe, See Louise E., Passmore, Margaret R., Barnett, Adrian G., Obonyo, Nchafatso G., Millar, Jonathan E., Suen, Jacky Y. and Fraser, John F. (2018). Neuron specific enolase and matrix metaloproteinase 9 signal silent brain infarction associated with TAVI. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

  • Han, Y., Ma, F., Ozols, E., Chew, P., Vesey, D., Gobe, G., Morais, C., Lohman, R., Suen, J., Fairlie, D. and Nikolic-Paterson, D. (2018). PAR-2 does not contribute to tubular damage or renal fibrosis in the obstructed kidney. 54th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Sydney, Australia, 8–12 September 2018. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/nep.13441

  • Fanning, Jonathon P., Obonyo, Nchafatso G., Tung, John-Paul, Byrne, Liam, Simonova, Gabriela, Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai-Ching, Hoe, See Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Fauzi, Hashairi Mohd, Pretti, Pimenta Leticia, Millar, Jonathan, Anstey, Christopher, van Haren, Frank, Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John (2018). Packed red cell age associated with adverse cardiovascular changes in an ovine model of septic shock resuscitation. -, -, 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins.

  • Tesch, G., Han, Y., Vesey, D., Gobe, G., Lohman, R., Suen, J., Fairlie, D. and Nikolic-Paterson, D. (2016). Pharmacological Inhibition of Protease-Activated Receptor 2 (Par2) Reduces Crescent Formation in Rat Anti-Gbm Disease. 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth, WA, Australia, 17–21 September 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12887

  • Owens, E., Iyer, A., Morais, C., Lohman, R., Suen, J., Johnson, D., Nikolic-Paterson, D., Gobe, G., Fairlie, D. and Vesey, D. (2016). Protease activated-receptor-2 induced inflammation and fibrosis is mediated in part through activation of transforming growth factor-beta signalling. The 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth Western Australia, 17–21 September 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12887

  • Yau, Mei Kwan, Suen, Jacky, Xu, Weijun, Lim, Junxian, Liu, Ligong, Adams, Mark, He, Yaowu, Hooper, John, Reid, Robert and Fairlie, David (2015). Potent small agonists of protease activated receptor 2. WASHINGTON: AMER CHEMICAL SOC.

  • Fairlie, David P. , Yau, Mei-Kwan , Hamidon, Johan K. , Singh, Ranee , Lim, Junxian , Suen, Jacky Y. , Rowley, Jessica A. , Lohman, Rink-Jan , Stoermer, Martin J. , Iyer, Abishek and Reid, Robert C. (2015). Downsizing Proteins Without Losing Potency or Function. American Peptide Symposium 2015, Orlando , Florida, United States, 20-25 June 2015. American Peptide Society. doi: 10.17952/24APS.2015.016

  • Yau, Annika M., Liu, Ligong, Reid, Robert C., Barry, Grant D., Suen, Jacky Y., Lohman, Rink-Jan, Le, Giang T., Cotterell, Adam and Fairlie, David P. (2011). Novel agonists and antagonists for protease activated receptor 2. National Meeting of the American Chemical Society (242nd, ACS, 2011), Denver, CO, U.S.A., 28 August-1 September 2011. WASHINGTON: AMER CHEMICAL SOC.

  • Vesey David A., Suen, Jacky Yung, Johnson, David W. and Fairlie, David (2010). A Novel Protease-Activated Receptor-2 Antagonist Targeting Inflammation and Proliferation in Human Renal Tubular Epithelial Cells. Kidney Week, American society of Nephrology, Denver Colorado USA, November 16 - 21. Journal of the American Society of Nephrology:

  • Vesey, D., Rajandram, R., Blakeney, J., Suen, J., Johnson, D., Fairlie, D. and Gobe, G. (2010). Protease-activated receptor-2 and renal carcinogenesis. 46th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth Convention and Exhibition Centre, Perth, Western Australia, 12-15 September 2010. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2010.01377_1.x

  • Fairlie, David P., Madala, Praveen K., Stoermer, Martin J., Suen, Jacky, Barry, Grant and Lohman, Rink-Jan (2009). Regulating protein and peptide activated GPCRs. 229th National Meeting of the American Chemical Society, San Diego, California, 13-17 March 2005. Washington DC, United States: American Chemical Society.

Other Outputs

  • Suen, Jacky Yung (2008). Regulating protease activated receptor 2. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2014.212

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • We are looking for honours students to be involved in our range of studies on cardiac/respiratory failure. Projects include heart transplantation, acute respiratory failure, sepsis and advanced life support. Students will be expected and supported for grant application, as most of our previous honours students were awarded with $10,000 New Investigator Grant.

  • We are looking for Honours and RHD students to be involved in our NHMRC-funded heart transplantation program. Previously, we have successfully translated our research on extended organ preservation to clinical practice in Australia/New Zealand. As we explore on a new donor source, we are looking for talented students to join the team to study mitochondrial dysfunction, as a key parameter in determining post-transplant cardiac function.

  • Extra-Corporeal Membrane Oxygenation (ECMO) is an artificial heart/lung machine that is use to support patients with severe cardiac/respiratory failure. It has been invented for more than 30 years. To date, there is a lack of systematic examination of various parameters and settings for ECMO. Many of the current clinical practise are based on convention and tradition. This project aims to research and provide empirical evidences in order to optimise ECMO usage for patients, leading to improved patient outcome and reduced length of hospital stay. The project could involve bench-top ex vivo experiments, large animal in vivo study, and, perspective and retrospective analysis of clinical studies.

  • We are looking for Honours or RHD students to be involved in a project examining the impact of blood flow to support patients with respiratory failure. The student will be using human primary lung cells to model the condition of respiratory failure and advanced life support. The project will be in partnership with a leading biomed tech industry partner.