John-Paul Tung is a Senior Research Fellow at Australian Red Cross Lifeblood (Lifeblood). He leads a program of research focused on the changes that occur in blood in between collection and transfusion, as well as how these changes might impact transfused patients. Particular focuses are on transfusion-related acute lung inujry (TRALI), transfusion-associated circulatory overload (TACO), and extracellular vesicles. He leads a research team of five Senior Research Assistants and three Research Assistants. He also supervises several PhD and Masters students. He holds an Honorary Senior Research Fellow position with the Faculty of Medicine at UQ. He also holds an adjunct Associate Professor position with the University of the Sunshine Coast and an adjunct Senior Lecturer position with QUT. He is also a former Secretary and Council Member of the International Society of Blood Transfusion's Young Professionals Council.
John-Paul completed a Bachelor of Science at UQ in 1999, after which he worked as a Scientist in nucleic acid testing in Brisbane, Melbourne and London. After returning to Brisbane, he commenced work as a Research Scientist with Lifeblood (formerly the Blood Service) in 2007. John-Paul then commenced a PhD with UQ and Prince Charles Hospital's Critical Care Research Group in 2008. His PhD, conferred in 2012, invovled the development of the first large animal model of TRALI using sheep, and resulted in several awards including best paper prizes from the International Society of Blood Transfusion and the Prince Charles Hospital as well as other awards from the Australian and New Zealand Society of Blood Transfusion and the British Blood Transfusion Society.
As well as internal Lifeblood research project funding, John-Paul has been an investigator on over 20 competitive external grants worth over $7.5 million, including from the NHMRC, the ARC, and the Emergency Medicine Foundation. John-Paul has published over 40 papers including in American Journal of Respiratory and Critical Care Medicine (JIF 30.5), Intensive Care Medicine (JIF 17.4), Critical Care (JIF 9.1), and Blood Reviews (JIF 8.3). He has presented at international and national conferences, inculding invited presenations at the International Society of Blood Transfusion Congress, the Royal College of Pathologists Association Pathology Update, and the Brazilian Congress of Hematology, Hemotherapy, and Cellular Therapy. He has supervised over 20 research students including three PhD completions, two Masters completions, and eight Honours completions. He has several on-going academic and clincal collaborations including with the the Royal Brisbane and Women's Hospital, the Prince Charles Hospital, the Australian Defence Force, and the Baker Institute.
Journal Article: Donor variability affects the outcome for the monocyte monolayer assay (MMA)
Tran, Thu V., Powley, Tanya, Tung, John-Paul, Flower, Robert L. and Dean, Melinda M. (2023). Donor variability affects the outcome for the monocyte monolayer assay (MMA). Pathology, 55, S98-S99. doi: 10.1016/j.pathol.2022.12.329
Journal Article: Molecular typing to personalise donor donation frequency
Flower, Robert L., Perros, Alexis J., Jacko, Georgina, Welvaert, Marijke, Viennet, Elvina, Hyland, Catherine, Tung, John-Paul and Roulis, Eileen (2023). Molecular typing to personalise donor donation frequency. Pathology, 55, S91. doi: 10.1016/j.pathol.2022.12.304
Journal Article: The impact of revised definitions for transfusion‐associated circulatory overload and transfusion‐related acute lung injury on haemovigilance reporting
Yuan, Yin, Dennington, Peta M., Daly, James, Baidya, Shoma and Tung, John‐Paul (2023). The impact of revised definitions for transfusion‐associated circulatory overload and transfusion‐related acute lung injury on haemovigilance reporting. Vox Sanguinis, 118 (3), 199-206. doi: 10.1111/vox.13402
Imaging the Microcirculation in Critical Care Research
(2014) NHMRC Equipment Grant
Investigating underlying mechanisms of transfusion related acute lung injury
Master Philosophy
(2020) Doctor Philosophy
Effects of commonly used and emerging resuscitation fluids on end organ function in severe trauma
Doctor Philosophy
Donor variability affects the outcome for the monocyte monolayer assay (MMA)
Tran, Thu V., Powley, Tanya, Tung, John-Paul, Flower, Robert L. and Dean, Melinda M. (2023). Donor variability affects the outcome for the monocyte monolayer assay (MMA). Pathology, 55, S98-S99. doi: 10.1016/j.pathol.2022.12.329
Molecular typing to personalise donor donation frequency
Flower, Robert L., Perros, Alexis J., Jacko, Georgina, Welvaert, Marijke, Viennet, Elvina, Hyland, Catherine, Tung, John-Paul and Roulis, Eileen (2023). Molecular typing to personalise donor donation frequency. Pathology, 55, S91. doi: 10.1016/j.pathol.2022.12.304
Yuan, Yin, Dennington, Peta M., Daly, James, Baidya, Shoma and Tung, John‐Paul (2023). The impact of revised definitions for transfusion‐associated circulatory overload and transfusion‐related acute lung injury on haemovigilance reporting. Vox Sanguinis, 118 (3), 199-206. doi: 10.1111/vox.13402
Chiaretti, Sara, Burton, Mark, Hassel, Penny, Radenkovic, Filip, Devikashri, Nilam, Sultana, Annette J, Temple, Fergal T, Dean, Melinda M and Tung, John-Paul (2022). Human neutrophil antigen 3 genotype impacts neutrophil-mediated endothelial cell cytotoxicity in a two-event model of TRALI. Blood transfusion = Trasfusione del sangue, 20 (6), 465-474. doi: 10.2450/2022.0013-22
Sivakaanthan, Aarany, Swain, Fiona, Pahn, Gail, Goodison, Kathryn, Gutta, Naadir, Holdsworth, Rhonda, Baidya, Shoma and Tung, John-Paul (2022). Transfusion-related acute lung injury (TRALI): a retrospective review of reported cases in Queensland, Australia over 20 years. Blood transfusion = Trasfusione del sangue, 20 (6), 454-464. doi: 10.2450/2022.0020-22
Al-Riyami, Arwa Z., Masser, Barbara, Herczenik, Eszter, Arora, Satyam, Boateng, Lilian Antwi, Dinardo, Carla Luana, Hutchinson, Tyler, Ji, Yanli, Langi Sasongko, Syeldy, Tung, John-Paul and Panchatcharam, Sathiya Murthi (2022). Psychological impact of the COVID-19 pandemic on young professionals in blood banks and transfusion services: A global cross-sectional survey. Vox Sanguinis, 117 (5), 685-692. doi: 10.1111/vox.13236
Tung, John-Paul, Chiaretti, Sara, Dean, Melinda M., Sultana, Annette J., Reade, Michael C. and Fung, Yoke Lin (2022). Transfusion-related acute lung injury (TRALI): potential pathways of development, strategies for prevention and treatment, and future research directions. Blood Reviews, 53 100926, 100926. doi: 10.1016/j.blre.2021.100926
Dyer, Wayne B., Simonova, Gabriela, Chiaretti, Sara, Bouquet, Mahe, Wellburn, Rebecca, Heinsar, Silver, Ainola, Carmen, Wildi, Karin, Sato, Kei, Livingstone, Samantha, Suen, Jacky Y., Irving, David O., Tung, John-Paul, li Bassi, Gianluigi and Fraser, John F. (2022). Recovery of organ-specific tissue oxygen delivery at restrictive transfusion thresholds after fluid treatment in ovine haemorrhagic shock. Intensive Care Medicine Experimental, 10 (1) 12, 12. doi: 10.1186/s40635-022-00439-6
See Hoe, Louise E., Wildi, Karin, Obonyo, Nchafatso G., Bartnikowski, Nicole, McDonald, Charles, Sato, Kei, Heinsar, Silver, Engkilde-Pedersen, Sanne, Diab, Sara, Passmore, Margaret R., Wells, Matthew A., Boon, Ai-Ching, Esguerra, Arlanna, Platts, David G., James, Lynnette, Bouquet, Mahe, Hyslop, Kieran, Shuker, Tristan, Ainola, Carmen, Colombo, Sebastiano M., Wilson, Emily S., Millar, Jonathan E., Malfertheiner, Maximillian V., Reid, Janice D., O’Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Sato, Noriko, He, Ting ... Fraser, John F. (2021). A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death. Intensive Care Medicine Experimental, 9 (1) 60, 1-24. doi: 10.1186/s40635-021-00425-4
Dyer, Wayne B., Tung, John-Paul, Li Bassi, Gianluigi, Wildi, Karin, Jung, Jae-Seung, Colombo, Sebastiano Maria, Rozencwajg, Sacha, Simonova, Gabriela, Chiaretti, Sara, Temple, Fergal T., Ainola, Carmen, Shuker, Tristan, Palmieri, Chiara, Shander, Aryeh, Suen, Jacky Y., Irving, David O. and Fraser, John F. (2021). An ovine model of haemorrhagic shock and resuscitation, to assess recovery of tissue oxygen delivery and oxygen debt, and inform patient blood management. Shock, 56 (6), 1080-1091. doi: 10.1097/SHK.0000000000001805
Simonova, Gabriela, Wellburn, Rebecca, Fung, Yoke Lin, Fraser, John F. and Tung, John‐Paul (2020). Ovine red cell concentrates for transfusion research – is the storage lesion comparable to human red cell concentrates?. Vox Sanguinis, 116 (5) vox.13020, 524-532. doi: 10.1111/vox.13020
Bouquet, Mahé, Passmore, Margaret R., See Hoe, Louise E., Tung, John-Paul, Simonova, Gabriela, Boon, Ai-Ching and Fraser, John F. (2020). Development and validation of ELISAs for the quantitation of interleukin (IL)-1β, IL-6, IL-8 and IL-10 in ovine plasma. Journal of Immunological Methods, 486 112835, 112835. doi: 10.1016/j.jim.2020.112835
Dean, Melinda M, Obeysekera, Maheshi P, Tran, Thu V, Sturgess, David, Wyssusek, Kerstin, Van Zundert, Andrea, Gordon, Louisa G, Da Silva, D, Punnasseril, J, Tung, John-Paul, Flower, Robert L and Roets, Michelle (2020). Autologous intraoperative cell salvage ameliorates suppression of transfusion-related monocyte and dendritic cell inflammatory responses. The Journal of Immunology, 204 (1_Supplement), 220.31-220.31. doi: 10.4049/jimmunol.204.supp.220.31
Perros, Alexis J, Chong, Fenny, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Rooks, Kelly, Faddy, Helen M, Hewlett, Elise, Naidoo, Rishendran, Tung, John-Paul, Fraser, John F, Tesar, Peter, Ziegenfuss, Marc, Smith, Susan, O’Brien, Donalee, Flower, Robert L and Dean, Melinda M (2020). Coronary artery bypass grafting surgery differentially modulates the leucocyte gene expression profile. The Journal of Immunology, 204 (1_Supplement), 69.18-69.18. doi: 10.4049/jimmunol.204.supp.69.18
Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells
Perros, Alexis J., Esguerra‐Lallen, Arlanna, Rooks, Kelly, Chong, Fenny, Engkilde‐Pedersen, Sanne, Faddy, Helen M., Hewlett, Elise, Naidoo, Rishendran, Tung, John‐Paul, Fraser, John F., Tesar, Peter, Ziegenfuss, Marc, Smith, Susan, O’Brien, Donalee, Flower, Robert L. and Dean, Melinda M. (2020). Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells. Journal of Cellular and Molecular Medicine, 24 (8) jcmm.15154, 4791-4803. doi: 10.1111/jcmm.15154
Roets, Michelle, Sturgess, David John, Obeysekera, Maheshi Prabodani, Tran, Thu Vinh, Wyssusek, Kerstin Hildegard, Punnasseril, Jaisil Eldo Jos, da Silva, Diana, van Zundert, Andre, Perros, Alexis Jacqueline, Tung, John Paul, Flower, Robert Lewis Powell and Dean, Melinda Margaret (2020). Intraoperative cell salvage as an alternative to allogeneic (donated) blood transfusion: a prospective observational evaluation of the immune response profile. Cell Transplantation, 29, 096368972096626. doi: 10.1177/0963689720966265
Ng, Monica Suet Ying, Hay, Karen, Choy, Joleen, Middelburg, Rutger A., Tung, John-Paul and Fraser, John Francis (2019). Fresh frozen plasma and platelet concentrate storage duration not associated with in hospital mortality risk. Vox Sanguinis, 114 (8) vox.12838, 835-841. doi: 10.1111/vox.12838
Perros, Alexis J, Esguerra-Lallen, Arlanna, Rooks, Kelly, Chong, Fenny N, Engkilde-Pedersen, Sanne, Faddy, Helen M, Hewlett, Elise, Naidoo, Rishendran, Tung, John-Paul, Fraser, John F, Tesar, Peter, Ziegenfuss, Marc, Smith, Susan, O'Brien, Donalee, Flower, Robert L and Dean, Melinda M (2019). Coronary artery bypass grafting surgery is associated with immunoparalysis of monocytes and dendritic cells. The Journal of Immunology, 202 (1_Supplement), 182.69-182.69. doi: 10.4049/jimmunol.202.supp.182.69
Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock
Passmore, Margaret R., Obonyo, Nchafatso G., Byrne, Liam, Boon, Ai-Ching, Diab, Sara D., Dunster, Kimble R., Fung, Yoke L., Spanevello, Michelle M., Fauzi, Mohd H., Pedersen, Sanne E., Simonova, Gabriela, Anstey, Chris M., Shekar, Kiran, Tung, John-Paul, Maitland, Kathryn and Fraser, John F. (2019). Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock. Thrombosis Research, 176, 39-45. doi: 10.1016/j.thromres.2019.02.015
Non-antibody mediated transfusion-related acute lung injury an enigma
Fung, Yoke Lin and Tung, John-Paul (2019). Non-antibody mediated transfusion-related acute lung injury an enigma. Annals of Blood, 4 (April) 7, 7. doi: 10.21037/aob.2019.03.02
Endothelialized flow models for blood transfusion research
Ng, Monica S. Y., Suen, Jacky Y., Tung, John-Paul and Fraser, John F. (2019). Endothelialized flow models for blood transfusion research. Haematologica, 104 (3), 428-434. doi: 10.3324/haematol.2018.205203
Pre-clinical study protocol: Blood transfusion in endotoxaemic shock
Obonyo, Nchafatso G., Byrne, Liam, Tung, John-Paul, Simonova, Gabriela, Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Fauzi, Mohd H., Pimenta, Leticia P., Millar, Jonathan E., Fanning, Jonathon P., Van Haren, Frank, Anstey, Chris M., Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2019). Pre-clinical study protocol: Blood transfusion in endotoxaemic shock. MethodsX, 6, 1124-1132. doi: 10.1016/j.mex.2019.05.005
Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock
Passmore, Margaret R., Byrne, Liam, Obonyo, Nchafatso G., See Hoe, Louise E., Boon, Ai-Ching, Diab, Sara D., Dunster, Kimble R., Bisht, Kavita, Tung, John-Paul, Fauzi, Mohd H., Narula, Monica, Pedersen, Sanne E., Esguerra-Lallen, Arlanna, Simonova, Gabriela, Sultana, Annette, Anstey, Chris M., Shekar, Kiran, Maitland, Kathryn, Suen, Jacky Y. and Fraser, John F. (2018). Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock. Respiratory Research, 19 (1) 231, 231. doi: 10.1186/s12931-018-0935-4
Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia
Byrne, Liam, Obonyo, Nchafatso G., Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Pedersen, Sanne, Hashairi Fauzi, Mohd, Pretti Pimenta, Leticia, Van Haren, Frank, Anstey, Christopher M., Cullen, Louise, Tung, John-Paul, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2018). Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia. American Journal of Respiratory and Critical Care Medicine, 198 (8), 1043-1054. doi: 10.1164/rccm.201801-0064OC
How different animal models help us understand TRALI
Fung, Y. L. and Tung, J. P. (2018). How different animal models help us understand TRALI. ISBT Science Series, 13 (3), 197-205. doi: 10.1111/voxs.12423
Ng, Monica S. Y., David, Michael, Middelburg, Rutger A., Ng, Angela S. Y., Suen, Jacky Y., Tung, John-Paul and Fraser, John F. (2018). Transfusion of packed red blood cells at the end of shelf life is associated with increased risk of mortality - a pooled patient data analysis of 16 observational trials. Haematologica, 103 (9), haematol.2018.191932-1548. doi: 10.3324/haematol.2018.191932
Platelet storage lesions: what more do we know now?
Ng, Monica Suet Ying, Tung, John-Paul and Fraser, John Francis (2018). Platelet storage lesions: what more do we know now?. Transfusion Medicine Reviews, 32 (3), 144-154. doi: 10.1016/j.tmrv.2018.04.001
An ovine model of hyperdynamic endotoxemia and vital organ metabolism
Byrne, Liam, Obonyo, Nchafatso G., Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai Ching, Hoe, Louise See, Hay, Karen, Van Haren, Frank, Tung, John-Paul, Cullen, Louise, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2018). An ovine model of hyperdynamic endotoxemia and vital organ metabolism. Shock, 49 (1), 99-107. doi: 10.1097/SHK.0000000000000904
Passmore, Margaret R., Fung, Yoke L., Simonova, Gabriela, Foley, Samuel R., Diab, Sara D., Dunster, Kimble R., Spanevello, Michelle M., McDonald, Charles I., Tung, John-Paul, Pecheniuk, Natalie M., Hay, Karen, Shekar, Kiran and Fraser, John F. (2017). Evidence of altered haemostasis in an ovine model of venovenous extracorporeal membrane oxygenation support. Critical Care, 21 (1) 191, 1-9. doi: 10.1186/s13054-017-1788-9
Aung, Htet Htet, Tung, John-Paul, Dean, Melinda M., Flower, Robert L. and Pecheniuk, Natalie M. (2017). Procoagulant role of microparticles in routine storage of packed red blood cells: potential risk for prothrombotic post-transfusion complications. Pathology, 49 (1), 62-69. doi: 10.1016/j.pathol.2016.10.001
Inflammation and lung injury in an ovine model of extracorporeal membrane oxygenation support
Passmore, Margaret R., Fung, Yoke L., Simonova, Gabriela, Foley, Samuel R., Dunster, Kimble R., Diab, Sara D., Tung, John-Paul, Minchinton, Robyn M., McDonald, Charles I., Anstey, Chris M., Shekar, Kiran and Fraser, John F. (2016). Inflammation and lung injury in an ovine model of extracorporeal membrane oxygenation support. AJP - Lung Cellular and Molecular Physiology, 311 (6), L1202-L1212. doi: 10.1152/ajplung.00296.2016
Ng, Monica Suet Ying, Ng, Angela Suet Yeung, Chan, Jessica, Tung, John-Paul and Fraser, John Francis (2015). Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: a meta-analysis and systematic review. Intensive Care Medicine, 41 (12), 2087-2097. doi: 10.1007/s00134-015-4078-5
Hepatitis C virus genotype 4 in England: diversity and demographic associations
Ngui, Siew-Lin, Brant, Lisa, Markov, Peter V., Tung, John-Paul, Pybus, Oliver G., Teo, Chong-Gee and Ramsay, Mary E. (2015). Hepatitis C virus genotype 4 in England: diversity and demographic associations. Journal of Medical Virology, 87 (3), 417-423. doi: 10.1002/jmv.24069
Letter: the need for a definitive clinical trial of cryopreserved red blood cells
Milford, Elissa M., Tung, John Paul and Reade, Michael C. (2014). Letter: the need for a definitive clinical trial of cryopreserved red blood cells. Journal of Trauma and Acute Care Surgery, 77 (6), 1004-1004. doi: 10.1097/TA.0000000000000463
Neutrophil antibodies are clinically important
Fung, Y. L., Tung, J. P. and Minchinton, R. M. (2014). Neutrophil antibodies are clinically important. ISBT Science Series, 9 (1), 253-257. doi: 10.1111/voxs.12062
Milford, Elissa M., Reade, Michael C., Colone, Lieutenant, Shekar, Kiran, Tung, John-Paul and Fraser, John F. (2014). An age-of-blood transfusion trial in the trauma setting is crucial and animal models may help inform trial design. Critical Care and Resuscitation, 16 (2), 149-150.
Chemonges, Saul, Shekar, Kiran, Tung, John-Paul, Dunster, Kimble R., Diab, Sara, Platts, David, Watts, Ryan P., Gregory, Shaun D., Foley, Samuel, Simonova, Gabriela, McDonald, Charles, Hayes, Rylan, Bellpart, Judith, Timms, Daniel, Chew, Michelle, Fung, Yoke L., Toon, Michael, Maybauer, Marc O. and Fraser, John F. (2014). Optimal management of the critically ill: anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care. BioMed Research International, 2014 (468309) 468309, 1-17. doi: 10.1155/2014/468309
Chemonges, Saul, Tung, John-Paul and Fraser, John F. (2014). Proteogenomics of selective susceptibility to endotoxin using circulating acute phase biomarkers and bioassay development in sheep: a review. Proteome Science, 12 doi: doi:10.1186/1477-5956-12-12
A comprehensive ovine model of blood transfusion
Simonova, G., Tung, J. P., Fraser, J. F., Do, H. L., Staib, A., Chew, M. S., Dunster, K. R., Glenister, K. M., Jackson, D. E. and Fung, Y. L. (2014). A comprehensive ovine model of blood transfusion. Vox Sanguinis, 106 (2), 153-160. doi: 10.1111/vox.12076
Fung, Y. L., Tung, J. P., Foley, S. R., Simonova, G., Thom, O., Staib, A., Collier, J., Dunster, K. R., Solano, C., Shekar, K., Chew, M. S. and Fraser, J. F. (2013). Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage. Vox Sanguinis, 105 (2), 150-158. doi: 10.1111/vox.12032
Tung, John-Paul, Fraser, John F., Nataatmadja, Maria, Colebourne, Kathryn I., Barnett, Adrian G., Glenister, Kristen M., Zhou, Anna Y., Wood, Peter, Silliman, Christopher C. and Fung, Yoke L. (2012). Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI). Critical Care, 16 (1) R19, R19.1-R19.14. doi: 10.1186/cc11178
A novel in vivo ovine model of transfusion-related acute lung injury (TRALI)
Tung, J. P., Fung, Y. L., Nataatmadja, M., Colebourne, K. I., Esmaeel, H. M., Wilson, K., Barnett, A. G., Wood, P., Silliman, C. C. and Fraser, J. F. (2011). A novel in vivo ovine model of transfusion-related acute lung injury (TRALI). Vox Sanguinis, 100 (2), 219-230. doi: 10.1111/j.1423-0410.2010.01381.x
Respiratory burst function of ovine neutrophils
Tung, John-Paul, Fraser, John F., Wood, Peter and Fung, Yoke L. (2009). Respiratory burst function of ovine neutrophils. BMC Immunology, 10 (1) 25, 25.1-25.11. doi: 10.1186/1471-2172-10-25
Worthley, Daniel L., Johnson, Douglas F., Eisen, Damon P., Dean, Melinda M., Heatley, Susan L., Tung, John-Paul, Scott, Justin, Padbury, Robert T. A., Harley, Hugh A., Bardy, Peter G., Angus, Peter W. and Mullighan, Charles G. (2009). Donor mannose-binding lectin deficiency increases the likelihood of clinically significant infection after liver transplantation. Clinical Infectious Diseases, 48 (4), 410-417. doi: 10.1086/596313
Inflammatory cytokine profiles in 24-hour brain stem death model
Boon, A. C., Hoe, L. E. See, Pederson, S. E., Obonyo, N. G., Wells, M. A., Bartnikowski, N. J., Passmore, M. R., Marshall, L., James, L., Tung, J., Suen, J. Y., Macdonald, P. S., McGiffin, D. C. and Fraser, J. F. (2018). Inflammatory cytokine profiles in 24-hour brain stem death model. 38th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation (ISHLT), Nice, France, 11-14 April 2018. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.healun.2018.01.506
Modulation of immune responses in patients following cardiac surgery
Perros, Alexis J., Esguerra-Lallen, Arlanna, Rooks, Kelly, Chong, Fenny, Flower, Robert L., Pedersen, Sanne Engkilde, Naidoo, Rishendran, Tung, John-Paul, Fraser, John, Tesar, Peter, Ziegenfuss, Marc, Smith, Susan, O’Brien, Donalee and Dean, Melinda M. (2017). Modulation of immune responses in patients following cardiac surgery. Pathology Update 2017, Sydney, NSW Australia, 24-26 February 2017. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1016/j.pathol.2016.12.317
Point-of-care testing in an ovine model of transfusion-related acute lung injury (TRALI)
Tung, John-Paul, Simonova, Gabriela, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Sultana, Annette, Hewlett, Elise, Obonyo, Nchafatso, Millar, Jonathan, Flower, Robert and Fraser, John (2017). Point-of-care testing in an ovine model of transfusion-related acute lung injury (TRALI). Pathology Update 2017, Sydney, NSW Australia, 24-26 February 2017. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2016.12.309
Roche, Elise, Passmore, Margaret, Simonova, Gabriela, Diab, Sara, Dunster, Kimble, Bierman, Wesley, Fraser, John and Tung, John-Paul (2016). A Histologic Approach to Qualify Lung Tissue Damage in a Sheep Model of Transfusion-Related Lung Injury: Role of Red Blood Cell Storage Duration and Heat Treatment. 2016 American Society of Clincial Pathology (ASCP) Annual Meeting, Las Vegas, NV United States, 14 -16 September 2016. Cary, NC United States: Oxford University Press.
Sultana, A., Meka, D., Dean, M. M., Simonova, G., Christensen, A-M, Flower, R. L. and Tung, J-P (2016). The potential of inflammatory responses to contribute to the development of transfusion-related acute lung injury (TRALI). International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.
Tung, John-Paul, Meka, Denisa, Sultana, Annette J., Simonova, Gabriela, Christensen, Anne-Marie, Flower, Robert L. and Dean, Melinda M. (2014). Potential Role of Bioactive Lipids in the Development of Non-Antibody Mediated Transfusion-Related Acute Lung Injury (TRALI). WASHINGTON: AMER SOC HEMATOLOGY.
Simonova, G., Fung, Y. L., Glenister, K. M., Fraser, J. F. and Tung, J-P (2013). The Ovine Packed Red Blood Cell Storage Lesion: Characterisation and Comparison to That of Human Packed Red Blood Cells. HOBOKEN: WILEY-BLACKWELL.
A validated ovine model for blood collection, processing, compatibility testing and transfusion
Fung, Y. L., Do, H. L., Tung, J. P., Collier, J. and Fraser, J. F. (2011). A validated ovine model for blood collection, processing, compatibility testing and transfusion. unknown, unknown, unknown. Oxford, United Kingdom: Wiley-Blackwell Publishing.
Evidence behind the pathophysiology of TRALI
Fung, Y. L., Tung, J. P., Minchinton, R. M. and Fraser, J. F. (2011). Evidence behind the pathophysiology of TRALI. unknown, unknown, unknown. MALDEN: WILEY-BLACKWELL.
A novel in-vivo ovine model of transfusion-related acute lung injury (TRALI)
Tung, J. P., Fraser, J. F., Nataatmadja, M., Colebourne, K. I., Esmaeel, H. M., Wilson, K., Barnett, A. G., Silliman, C. C., Wood, P. and Fung, Yoke Lin (2010). A novel in-vivo ovine model of transfusion-related acute lung injury (TRALI). XIth European Symposium on Platelet and Granulocyte Immunobiology, Beaune, France, 21-24 October 2010. Oxford, United Kingdom: Wiley-Blackwell Publishing.
Tung, John-Paul, Fraser, John F., Nataatmadja, Maria, Barnett, Adrian G., Colebourne, Kathryn I., Glenister, Kristen M., Zhou, Anna Y., Wood, Peter, Silliman, Christopher C. and Fung, Yoke Lin (2010). Dissimilar respiratory and hemodynamic responses in TRALI induced by stored red cells and whole blood platelets. 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Orlando, FL, United States, 4-7 Dec 2010. Orlando, FL, United States: American Society of Hematology.
Worthley, D. L., Johnson, D. F., Eisen, D. P., Dean, M. M., Heatley, S., Tung, J-P, Scott, J., Padbury, R., Harley, H., Mullighan, C. G., Angus, P. W. and Bardy, P. G. (2008). Donor-derived mannose-binding lectin deficiency increases the risk of infection after liver transplantation. WILEY-BLACKWELL PUBLISHING, INC.
Development of an ovine model of transfusion-related acute lung injury (TRALI)
Tung, John-Paul (2012). Development of an ovine model of transfusion-related acute lung injury (TRALI). PhD Thesis, School of Medicine, The University of Queensland.
Imaging the Microcirculation in Critical Care Research
(2014) NHMRC Equipment Grant
Investigating underlying mechanisms of transfusion related acute lung injury
Master Philosophy — Principal Advisor
Other advisors:
Effects of commonly used and emerging resuscitation fluids on end organ function in severe trauma
Doctor Philosophy — Associate Advisor
Other advisors:
(2020) Doctor Philosophy — Principal Advisor
Other advisors:
A Translational Approach to Potential Toxicity of Stored Blood Components
(2019) Doctor Philosophy — Associate Advisor
Other advisors: