The University of Queensland

Assessment of in Vivo siRNA delivery in cancer mouse models

Hatakeyama, Hiroto, Wu, Sherry Y., Mangala, Lingegowda S., Lopez-Berestein, Gabriel and Sood, Anil K. (2016). Assessment of in Vivo siRNA delivery in cancer mouse models. Long non-coding RNAs: methods and protocols. (pp. 189-197) edited by Yi Feng and Lin Zhang. Totowa, NJ USA: Humana Press. doi: 10.1007/978-1-4939-3378-5_15

Lowering the sirna delivery barrier: Alginate scaffolds and immune stimulation

McCaskill, Jana, Wu, Sherry, Khairuddin, Norliana and McMillan, Nigel A. J. (2013). Lowering the sirna delivery barrier: Alginate scaffolds and immune stimulation. Nanotechnology for the delivery of therapeutic nucleic acids. (pp. 193-216) edited by Dan Peer. Singapore: Pan Stanford Publishing. doi: 10.4032/9789814411059

miR-146a inhibits ovarian tumour growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration

Chen, Rui, Coleborn, Elaina, Bhavsar, Chintan, Wang, Yue, Alim, Louisa, Wilkinson, Andrew N., Tran, Michelle A., Irgam, Gowri, Atluri, Sharat, Wong, Kiefer, Shim, Jae-Jun, Adityan, Siddharth, Lee, Ju-Seog, Overwijk, Willem W., Steptoe, Raymond, Yang, Da and Wu, Sherry Y. (2023). miR-146a inhibits ovarian tumour growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration. Molecular Therapy - Oncolytics, 31 100725, 100725. doi: 10.1016/j.omto.2023.09.001

Molecular analysis of short- versus long-term survivors of high-grade serous ovarian carcinoma

Stur, Elaine, Bayraktar, Emine, Dal Molin, Graziela Zibetti, Wu, Sherry Y., Mangala, Lingegowda S., Yao, Hui, Wang, Ying, Ram, Prahlad T., Corvigno, Sara, Chen, Hu, Liang, Han, Tworoger, Shelley S., Levine, Douglas A., Lutgendorf, Susan K., Liu, Jinsong, Moore, Kathleen N., Baggerly, Keith A., Karlan, Beth Y. and Sood, Anil K. (2022). Molecular analysis of short- versus long-term survivors of high-grade serous ovarian carcinoma. Cancers, 14 (17) 4198. doi: 10.3390/cancers14174198

Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling

McGuire, Michael H., Dasari, Santosh K., Yao, Hui, Wen, Yunfei, Mangala, Lingegowda S., Bayraktar, Emine, Ma, Wencai, Ivan, Cristina, Shoshan, Einav, Wu, Sherry Y., Jonasch, Eric, Bar-Eli, Menashe, Wang, Jing, Baggerly, Keith A. and Sood, Anil K. (2021). Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling. Molecular Cancer Research, 19 (11), 1917-1928. doi: 10.1158/1541-7786.MCR-20-0753

CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance

Ma, Shaolin, Mangala, Lingegowda S., Hu, Wen, Bayaktar, Emine, Yokoi, Akira, Hu, Wei, Pradeep, Sunila, Lee, Sanghoon, Piehowski, Paul D., Villar-Prados, Alejandro, Wu, Sherry Y., McGuire, Michael H., Lara, Olivia D., Rodriguez-Aguayo, Cristian, LaFargue, Christopher J., Jennings, Nicholas B., Rodland, Karin D., Liu, Tao, Kundra, Vikas, Ram, Prahlad T., Ramakrishnan, Sundaram, Lopez-Berestein, Gabriel, Coleman, Robert L. and Sood, Anil K. (2021). CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance. Cell Reports, 36 (7). doi: 10.1016/j.celrep.2021.109549

Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype

Ma, Shaolin, McGuire, Michael H., Mangala, Lingegowda S., Lee, Sanghoon, Stur, Elaine, Hu, Wen, Bayraktar, Emine, Villar-Prados, Alejandro, Ivan, Cristina, Wu, Sherry Y., Yokoi, Akira, Dasari, Santosh K., Jennings, Nicholas B., Liu, Jinsong, Lopez-Berestein, Gabriel, Ram, Prahlad and Sood, Anil K. (2021). Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. Cell Reports, 34 (6). doi: 10.1016/j.celrep.2021.108726

HIF and COX-2 expression in triple negative breast cancer cells with hypoxia and 5-fluorouracil

Mori, Noriko, Mironchik, Yelena, Wildes, Flonné, Wu, Sherry Y., Mori, Kanami, Krishnamachary, Balaji and Bhujwalla, Zaver M. (2020). HIF and COX-2 expression in triple negative breast cancer cells with hypoxia and 5-fluorouracil. Current Cancer Reports, 2 (1), 54-63. doi: 10.25082/CCR.2020.01.005

Nano-therapeutics for modulating the tumour microenvironment: design, development, and clinical translation

Adityan, Siddharth, Tran, Michelle, Bhavsar, Chintan and Wu, Sherry Y. (2020). Nano-therapeutics for modulating the tumour microenvironment: design, development, and clinical translation. Journal of Controlled Release, 327 (Acta Biomater. 62 2017), 512-532. doi: 10.1016/j.jconrel.2020.08.016

The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis

Noh, Kyunghee, Duc-Hiep Bach, , Choi, Hyun-Jin, Kim, Mark S., Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Cho, Min-Soon, Bayraktar, Emine, Rodriguez-Aguayo, Cristian, Dasari, Santosh K., Stur, Elaine, Mangala, Lingegowda S., Lopez-Berestein, Gabriel and Sood, Anil K. (2020). The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis. Oncogene, 40 (2), 384-395. doi: 10.1038/s41388-020-01517-3

Characterization of and isolation methods for plant leaf nanovesicles and small extracellular vesicles

Liu, Yuan, Wu, Sherry, Koo, Yeonjong, Yang, An, Dai, Yanwan, Khant, Htet, Osman, Samantha R., Chowdhury, Mamur, Wei, Haichao, Li, Yang, Court, Karem, Hwang, Elaine, Wen, Yunfei, Dasari, Santosh K., Nguyen, Michael, Tang, E. Chia-Cheng, Chehab, E. Wassim, de Val, Natalia, Braam, Janet and Sood, Anil K. (2020). Characterization of and isolation methods for plant leaf nanovesicles and small extracellular vesicles. Nanomedicine-Nanotechnology Biology and Medicine, 29 102271. doi: 10.1016/j.nano.2020.102271

NRG1/ERBB3 pathway activation induces acquired resistance to XPO1 inhibitors

Miyake, Takahito M., Pradeep, Sunila, Bayraktar, Emine, Stur, Elaine, Handley, Katelyn F., Wu, Sherry Y., Rodriguez-Aguayo, Cristian, Lee, Ju-Seog, Lopez-Berestein, Gabriel, Coleman, Robert L. and Sood, Anil K. (2020). NRG1/ERBB3 pathway activation induces acquired resistance to XPO1 inhibitors. Molecular Cancer Therapeutics, 19 (8), 1727-1735. doi: 10.1158/1535-7163.MCT-19-0977

Copper-64 labeled PEGylated exosomes for in vivo positron emission tomography and enhanced tumor retention

Shi, Sixiang, Li, Tingting, Wen, Xiaofei, Wu, Sherry Y., Xiong, Chiyi, Zhao, Jun, Lincha, Victor R., Chow, Diana S., Liu, Yiyao, Sood, Anil K. and Li, Chun (2019). Copper-64 labeled PEGylated exosomes for in vivo positron emission tomography and enhanced tumor retention. Bioconjugate Chemistry, 30 (10), 2675-2683. doi: 10.1021/acs.bioconjchem.9b00587

Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma

Endo-Munoz, Liliana, Bennett, Tristram C., Topkas, Eleni, Wu, Sherry Y., Thamm, Douglas H., Brockley, Laura, Cooper, Maureen, Sommerville, Scott, Thomson, Maurine, O'Connell, Kathleen, Lane, Amy, Bird, Guy, Peaston, Anne, Matigian, Nicholas, Straw, Rodney C. and Saunders, Nicholas A. (2019). Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma. Veterinary and Comparative Oncology, 18 (2) vco.12533, 206-213. doi: 10.1111/vco.12533

Pan-cancer genomic analysis links 3'UTR DNA methylation with increased gene expression in T cells

McGuire, Michael H., Herbrich, Shelley M., Dasari, Santosh K., Wu, Sherry Y., Wang, Ying, Rupaimoole, Rajesha, Lopez-Berestein, Gabriel, Baggerly, Keith A. and Sood, Anil K. (2019). Pan-cancer genomic analysis links 3'UTR DNA methylation with increased gene expression in T cells. Ebiomedicine, 43, 127-137. doi: 10.1016/j.ebiom.2019.04.045

Predicting novel therapies and targets: regulation of notch3 by the Bromodomain protein BRD4

Villar-Prados, Alejandro, Wu, Sherry Y., Court, Karem A., Ma, Shaolin, LaFargue, Christopher, Chowdhury, Mamur A., Engelhardt, Margaret I., Ivan, Cristina, Ram, Prahlad T., Wang, Ying, Baggerly, Keith, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Ming-Yang, Shyh, Maloney, David J., Yoshioka, Makoto, Strovel, Jeffrey W., Roszik, Jason and Sood, Anil K. (2019). Predicting novel therapies and targets: regulation of notch3 by the Bromodomain protein BRD4. Molecular Cancer Therapeutics, 18 (2), 421-436. doi: 10.1158/1535-7163.MCT-18-0365

Advances and challenges in nanomedicine

Hua, Susan and Wu, Sherry Y. (2018). Advances and challenges in nanomedicine. Frontiers in Pharmacology, 9 (Nov) 1397, 1397. doi: 10.3389/fphar.2018.01397

The advances and challenges in utilizing exosomes for delivering cancer therapeutics

Yang, Mengliu and Wu, Sherry Y. (2018). The advances and challenges in utilizing exosomes for delivering cancer therapeutics. Frontiers in Pharmacology, 9 (JUL) 735, 735. doi: 10.3389/fphar.2018.00735

Immune cell profiling in cancer: molecular approaches to cell-specific identification

Lyons, Yasmin A., Wu, Sherry Y., Overwijk, Willem W., Baggerly, Keith A. and Sood, Anil K. (2017). Immune cell profiling in cancer: molecular approaches to cell-specific identification. Npj Precision Oncology, 1 (26) 26. doi: 10.1038/s41698-017-0031-0

PRKCI promotes immune suppression in ovarian cancer

Sarkar, Sharmistha, Bristow, Christopher A., Dey, Prasenjit, Rai, Kunal, Perets, Ruth, Ramirez-Cardenas, Alejandra, Malasi, Shruti, Huang-Hobbs, Emmet, Haemmerle, Monika, Wu, Sherry Y., McGuire, Michael, Protopopov, Alexei, Jiang, Shan, Liu, Joyce F., Hirsch, Michelle S., Chang, Qing, Lazar, Alexander J., Sood, Anil K., Drapkin, Ronny, DePinho, Ronald, Draetta, Giulio and Chin, Lynda (2017). PRKCI promotes immune suppression in ovarian cancer. Genes and Development, 31 (11), 1109-1121. doi: 10.1101/gad.296640.117

Preclinical mammalian safety studies of EPHARNA (DOPC Nanoliposomal EphA2-Targeted siRNA)

Wagner, Michael J., Mitra, Rahul, McArthur, Mark J., Baze, Wallace, Barnhart, Kirstin, Wu, Sherry Y., Rodriguez-Aguayo, Cristian, Zhang, Xinna, Coleman, Robert L., Lopez-Berestein, Gabriel and Sood, Anil K. (2017). Preclinical mammalian safety studies of EPHARNA (DOPC Nanoliposomal EphA2-Targeted siRNA). Molecular Cancer Therapeutics, 16 (6), 1114-1123. doi: 10.1158/1535-7163.MCT-16-0541

HSP70 inhibition synergistically enhances the effects of magnetic fluid hyperthermia in ovarian cancer

Court, Karem A., Hatakeyama, Hiroto, Wu, Sherry Y., Lingegowda, Mangala S., Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Ju-Seog, Lee, Rinaldi, Carlos, Juan, Eduardo J., Sood, Anil K. and Torres-Lugo, Madeline (2017). HSP70 inhibition synergistically enhances the effects of magnetic fluid hyperthermia in ovarian cancer. Molecular Cancer Therapeutics, 16 (5), 966-976. doi: 10.1158/1535-7163.MCT-16-0519

BET inhibitors suppress ALDH activity by targeting ALDH1A1 super-enhancer in ovarian cancer

Yokoyama, Yuhki, Zhu, Hengrui, Lee, Jeong Heon, Kossenkov, Andrew V., Wu, Sherry Y., Wickramasinghe, Jayamanna M., Yin, Xiangfan, Palozola, Katherine C., Gardini, Alessandro, Showe, Louise C., Zaret, Kenneth S., Liu, Qin, Speicher, David, Conejo-Garcia, Jose R., Bradner, James E., Zhang, Zhiguo, Sood, Anil K., Ordog, Tamas, Bitler, Benjamin G. and Zhang, Rugang (2016). BET inhibitors suppress ALDH activity by targeting ALDH1A1 super-enhancer in ovarian cancer. Cancer Research, 76 (21), 6320-6330. doi: 10.1158/0008-5472.CAN-16-0854

Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers

Hatakeyama, Hiroto, Wu, Sherry Y., Lyons, Yasmin A., Pradeep, Sunila, Wang, Wanqin, Huang, Qian, Court, Karem A., Liu, Tao, Nie, Song, Rodriguez-Aguayo, Cristian, Shen, Fangrong, Huang, Yan, Hisamatsu, Takeshi, Mitamura, Takashi, Jennings, Nicholas, Shim, Jeajun, Dorniak, Piotr L., Mangala, Lingegowda S., Petrillo, Marco, Petyuk, Vladislav A., Schepmoes, Athena A., Shukla, Anil K., Torres-Lugo, Madeline, Lee, Ju-Seog, Rodland, Karin D., Fagotti, Anna, Lopez-Berestein, Gabriel, Li, Chun and Sood, Anil K. (2016). Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers. Cell Reports, 17 (6), 1621-1631. doi: 10.1016/j.celrep.2016.10.020

Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression

Rupaimoole, R., Ivan, C., Yang, D., Gharpure, K. M., Wu, S. Y., Pecot, C. V., Previs, R. A., Nagaraja, A. S., Armaiz-Pena, G. N., McGuire, M., Pradeep, S., Mangala, L. S., Rodriguez-Aguayo, C., Huang, L., Bar-Eli, M., Zhang, W., Lopez-Berestein, G., Calin, G. A. and Sood, A. K. (2016). Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. Oncogene, 35 (33), 4312-4320. doi: 10.1038/onc.2015.492

Role of increased n-acetylaspartate Levels in cancer

Zand, Behrouz, Previs, Rebecca A., Zacharias, Niki M., Rupaimoole, Rajesha, Mitamura, Takashi, Nagaraja, Archana Sidalaghatta, Guindani, Michele, Dalton, Heather J., Yang, Lifeng, Baddour, Joelle, Achreja, Abhinav, Hu, Wei, Pecot, Chad V., Ivan, Cristina, Wu, Sherry Y., McCullough, Christopher R., Gharpure, Kshipra M., Shoshan, Einav, Pradeep, Sunila, Mangala, Lingegowda S., Rodriguez-Aguayo, Cristian, Wang, Ying, Nick, Alpa M., Davies, Michael A., Armaiz-Pena, Guillermo, Liu, Jinsong, Lutgendorf, Susan K., Baggerly, Keith A., Bar Eli, Menashe ... Sood, Anil K. (2016). Role of increased n-acetylaspartate Levels in cancer. JNCI-Journal of the National Cancer Institute, 108 (6), djv426. doi: 10.1093/jnci/djv426

FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal

Haemmerle, Monika, Bottsford-Miller, Justin, Pradeep, Sunila, Taylor, Morgan L., Choi, Hyun-Jin, Hansen, Jean M., Dalton, Heather J., Stone, Rebecca L., Cho, Min Soon, Nick, Alpa M., Nagaraja, Archana S., Gutschner, Tony, Gharpure, Kshipra M., Mangala, Lingegowda S., Rupaimoole, Rajesha, Han, Hee Dong, Zand, Behrouz, Armaiz-Pena, Guillermo N., Wu, Sherry Y., Pecot, Chad V., Burns, Alan R., Lopez-Berestein, Gabriel, Afshar-Kharghan, Vahid and Sood, Anil K. (2016). FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal. Journal of Clinical Investigation, 126 (5), 1885-1896. doi: 10.1172/JCI85086

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

Wu, Sherry Y., Rupaimoole, Rajesha, Shen, Fangrong, Pradeep, Sunila, Pecot, Chad V., Ivan, Cristina, Nagaraja, Archana S., Gharpure, Kshipra M., Pham, Elizabeth, Hatakeyama, Hiroto, McGuire, Michael H., Haemmerle, Monika, Vidal-Anaya, Viviana, Olsen, Courtney, Rodriguez-Aguayo, Cristian, Filant, Justyna, Ehsanipour, Ehsan A., Herbrich, Shelley M., Maiti, Sourindra N., Huang, Li, Kim, Ji Hoon, Zhang, Xinna, Han, Hee-Dong, Armaiz-Pena, Guillermo N., Seviour, Elena G., Tucker, Sue, Zhang, Min, Yang, Da, Cooper, Laurence J. N. ... Sood, Anil K. (2016). A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nature Communications, 7 (1) 11169. doi: 10.1038/ncomms11169

Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis

Rupaimoole, Rajesha, Lee, Jaehyuk, Haemmerle, Monika, Ling, Hui, Previs, Rebecca A., Pradeep, Sunila, Wu, Sherry Y., Ivan, Cristina, Ferracin, Manuela, Dennison, Jennifer B., Millward, Niki M. Zacharias, Nagaraja, Archana S., Gharpure, Kshipra M., McGuire, Michael, Sam, Nidhin, Armaiz-Pena, Guillermo N., Sadaoui, Nouara C., Rodriguez-Aguayo, Cristian, Calin, George A., Drapkin, Ronny I., Kovacs, Jeffery, Mills, Gordon B., Zhang, Wei, Lopez-Berestein, Gabriel, Bhattacharya, Pratip K. and Sood, Anil K. (2015). Long noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis. Cell Reports, 13 (11), 2395-2402. doi: 10.1016/j.celrep.2015.11.047

Advances and challenges of liposome assisted drug delivery

Sercombe, Lisa, Veerati, Tejaswi, Moheimani, Fatemeh, Wu, Sherry Y., Sood, Anil K. and Hua, Susan (2015). Advances and challenges of liposome assisted drug delivery. Frontiers in Pharmacology, 6. doi: 10.3389/fphar.2015.00286

Erythropoietin stimulates tumor growth via EphB4

Pradeep, Sunila, Huang, Jie, Mora, Edna M., Nick, Alpa M., Cho, Min Soon, Wu, Sherry Y., Noh, Kyunghee, Pecot, Chad V., Rupaimoole, Rajesha, Stein, Martin A., Brock, Stephan, Wen, Yunfei, Xiong, Chiyi, Gharpure, Kshipra, Hansen, Jean M., Nagaraja, Archana S., Previs, Rebecca A., Vivas-Mejia, Pablo, Han, Hee Dong, Hu, Wei, Mangala, Lingegowda S., Zand, Behrouz, Stagg, Loren J., Ladbury, John E., Ozpolat, Bulent, Alpay, S. Neslihan, Nishimura, Masato, Stone, Rebecca L., Matsuo, Koji ... Sood, Anil K. (2015). Erythropoietin stimulates tumor growth via EphB4. Cancer Cell, 28 (5), 610-622. doi: 10.1016/j.ccell.2015.09.008

Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy

Gaur, Sanchaika, Wen, Yunfei, Song, Jian H., Parikh, Nila U., Mangala, Lingegowda S., Blessing, Alicia M., Ivan, Cristina, Wu, Sherry Y., Varkaris, Andreas, Shi, Yan, Lopez-Berestein, Gabriel, Frigo, Daniel E., Sood, Anil K. and Gallick, Gary E. (2015). Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy. Oncotarget, 6 (30), 29161-29177. doi: 10.18632/oncotarget.4971

Nanotechnology: future of oncotherapy

Gharpure, Kshipra M., Wu, Sherry Y., Li, Chun, Lopez-Berestein, Gabriel and Sood, Anil K. (2015). Nanotechnology: future of oncotherapy. Clinical Cancer Research, 21 (14), 3121-3130. doi: 10.1158/1078-0432.CCR-14-1189

XPO1/CRM1 inhibition causes antitumor effects by mitochondrial accumulation of eIF5A

Miyake, Takahito, Pradeep, Sunila, Wu, Sherry Y., Rupaimoole, Rajesha, Zand, Behrouz, Wen, Yunfei, Gharpure, Kshipra M., Nagaraja, Archana S., Hu, Wei, Cho, Min Soon, Dalton, Heather J., Previs, Rebecca A., Taylor, Morgan L., Hisamatsu, Takeshi, Kang, Yu, Liu, Tao, Shacham, Sharon, McCauley, Dilara, Hawke, David H., Wiktorowicz, John E., Coleman, Robert L. and Sood, Anil K. (2015). XPO1/CRM1 inhibition causes antitumor effects by mitochondrial accumulation of eIF5A. Clinical Cancer Research, 21 (14), 3286-3297. doi: 10.1158/1078-0432.CCR-14-1953

Therapeutic silencing of KRAS using systemically delivered siRNAs

Pecot, Chad V., Wu, Sherry Y., Bellister, Seth, Filant, Justyna, Rupaimoole, Rajesha, Hisamatsu, Takeshi, Bhattacharya, Rajat, Maharaj, Anshumaan, Azam, Salma, Rodriguez-Aguayo, Cristian, Nagaraja, Archana S., Morelli, Maria Pia, Gharpure, Kshipra M., Waugh, Trent A., Gonzalez-Villasana, Vianey, Zand, Behrouz, Dalton, Heather J., Kopetz, Scott, Lopez-Berestein, Gabriel, Ellis, Lee M. and Sood, Anil K. (2014). Therapeutic silencing of KRAS using systemically delivered siRNAs. Molecular Cancer Therapeutics, 13 (12), 2876-2885. doi: 10.1158/1535-7163.MCT-14-0074

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Rupaimoole, Rajesha, Wu, Sherry Y., Pradeep, Sunila, Ivan, Cristina, Pecot, Chad V., Gharpure, Kshipra M., Nagaraja, Archana S., Armaiz-Pena, Guillermo N., McGuire, Michael, Zand, Behrouz, Dalton, Heather J., Filant, Justyna, Miller, Justin Bottsford, Lu, Chunhua, Sadaoui, Nouara C., Mangala, Lingegowda S., Taylor, Morgan, van den Beucken, Twan, Koch, Elizabeth, Rodriguez-Aguayo, Cristian, Huang, Li, Bar-Eli, Menashe, Wouters, Bradly G., Radovich, Milan, Ivan, Mircea, Calin, George A., Zhang, Wei, Lopez-Berestein, Gabriel and Sood, Anil K. (2014). Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nature Communications, 5 (5202) 5202. doi: 10.1038/ncomms6202

Hematogenous metastasis of ovarian cancer: rethinking mode of spread

Pradeep, Sunila, Kim, Seung W., Wu, Sherry Y., Nishimura, Masato, Chaluvally-Raghavan, Pradeep, Miyake, Takahito, Pecot, Chad V., Kim, Sun-Jin, Choi, Hyun Jin, Bischoff, Farideh Z., Mayer, Julie Ann, Huang, Li, Nick, Alpa M., Hall, Carolyn S., Rodriguez-Aguayo, Cristian, Zand, Behrouz, Dalton, Heather J., Arumugam, Thiruvengadam, Lee, Ho Jeong, Han, Hee Dong, Cho, Min Soon, Rupaimoole, Rajesha, Mangala, Lingegowda S., Sehgal, Vasudha, Oh, Sang Cheul, Liu, Jinsong, Lee, Ju-Seog, Coleman, Robert L., Ram, Prahlad ... Sood, Anil K. (2014). Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell, 26 (1), 77-91. doi: 10.1016/j.ccr.2014.05.002

Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer

Gharpure, Kshipra M., Chu, Kevin S., Bowerman, Charles J., Miyake, Takahito, Pradeep, Sunila, Mangala, Selanere L., Han, Hee-Dong, Rupaimoole, Rajesha, Armaiz-Pena, Guillermo N., Rahhal, Tojan B., Wu, Sherry Y., Luft, J. Christopher, Napier, Mary E., Lopez-Berestein, Gabriel, DeSimone, Joseph M. and Sood, Anil K. (2014). Metronomic docetaxel in PRINT nanoparticles and EZH2 silencing have synergistic antitumor effect in ovarian cancer. Molecular Cancer Therapeutics, 13 (7), 1750-1757. doi: 10.1158/1535-7163.MCT-13-0930

Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer

Tucker, Susan L., Gharpure, Kshipra, Herbrich, Shelley M., Unruh, Anna K., Nick, Alpa M., Crane, Erin K., Coleman, Robert L., Guenthoer, Jamie, Dalton, Heather J., Wu, Sherry Y., Rupaimoole, Rajesha, Lopez-Berestein, Gabriel, Ozpolat, Bulent, Ivan, Cristina, Hu, Wei, Baggerly, Keith A. and Sood, Anil K. (2014). Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer. Clinical Cancer Research, 20 (12), 3280-3288. doi: 10.1158/1078-0432.CCR-14-0445

Notch3 pathway alterations in ovarian cancer

Hu, Wei, Liu, Tao, Ivan, Cristina, Sun, Yunjie, Huang, Jie, Mangala, Lingegowda S., Miyake, Takahito, Dalton, Heather J., Pradeep, Sunila, Rupaimoole, Rajesh, Previs, Rebecca A., Han, Hee Dong, Bottsford-Miller, Justin, Zand, Behrouz, Kang, Yu, Pecot, Chad V., Nick, Alpa M., Wu, Sherry Y., Lee, Ju-Seog, Sehgal, Vasudha, Ram, Prahlad, Liu, Jinsong, Tucker, Susan L., Lopez-Berestein, Gabriel, Baggerly, Keith A., Coleman, Robert L. and Sood, Anil K. (2014). Notch3 pathway alterations in ovarian cancer. Cancer Research, 74 (12), 3282-3293. doi: 10.1158/0008-5472.CAN-13-2066

RNAi therapies: drugging the undruggable

Wu, S. Y., Lopez-Berestein, G., Calin, G. A. and Sood, A. K. (2014). RNAi therapies: drugging the undruggable. Science Translational Medicine, 6 (240), 240ps7-240ps7. doi: 10.1126/scitranslmed.3008362

2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

Wu, Sherry Y., Yang, Xianbin, Gharpure, Kshipra M., Hatakeyama, Hiroto, Egli, Martin, McGuire, Michael H., Nagaraja, Archana S., Miyake, Takahito M., Rupaimoole, Rajesha, Pecot, Chad V., Taylor, Morgan, Pradeep, Sunila, Sierant, Malgorzata, Rodriguez-Aguayo, Cristian, Choi, Hyun J., Previs, Rebecca A., Armaiz-Pena, Guillermo N., Huang Li, Martinez, Carlos, Hassell Tom, Ivan, Cristina, Sehgal, Vasudha, Singhania, Richa, Han, Hee-Dong, Su, Chang, Kim, Ji Hoon, Dalton, Heather J., Kovvali, Chandra, Keyomarsi, Khandan ... Sood, Anil K. (2014). 2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. Nature Communications, 5 (1) 3459. doi: 10.1038/ncomms4459

Autocrine effects of tumor-derived complement

Cho, Min Soon, Vasquez, Hernan G., Rupaimoole, Rajesha, Pradeep, Sunila, Wu, Sherry, Zand, Behrouz, Han, Hee-Dong, Rodriguez-Aguayo, Cristian, Bottsford-Miller, Justin, Huang, Jie, Miyake, Takahito, Choi, Hyun-Jin, Dalton, Heather J., Ivan, Cristina, Baggerly, Keith, Lopez-Berestein, Gabriel, Sood, Anil K. and Afshar-Kharghan, Vahid (2014). Autocrine effects of tumor-derived complement. Cell Reports, 6 (6), 1085-1095. doi: 10.1016/j.celrep.2014.02.014

Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment

Nishimura, Masato, Jung, Eun-Jung, Shah, Maitri Y., Lu, Chunhua, Spizzo, Riccardo, Shimizu, Masayoshi, Han, Hee Dong, Ivan, Cristina, Rossi, Simona, Zhang, Xinna, Nicoloso, Milena S., Wu, Sherry Y., Almeida, Maria Ines, Bottsford-Miller, Justin, Pecot, Chad V., Zand, Behrouz, Matsuo, Koji, Shahzad, Mian M., Jennings, Nicholas B., Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Sood, Anil K. and Calin, George A. (2013). Therapeutic synergy between microRNA and siRNA in ovarian cancer treatment. Cancer Discovery, 3 (11), 1302-1315. doi: 10.1158/2159-8290.CD-13-0159

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer

Kim, Hyun Seok, Mendiratta, Saurabh, Kim, Jiyeon, Pecot, Chad Victor, Larsen, Jill E., Zubovych, Iryna, Seo, Bo Yeun, Kim, Jimi, Eskiocak, Banu, Chung, Hannah, McMillan, Elizabeth, Wu, Sherry, De Brabander, Jef, Komurov, Kakajan, Toombs, Jason E., Wei, Shuguang, Peyton, Michael, Williams, Noelle, Gazdar, Adi F., Posner, Bruce A., Brekken, Rolf A., Sood, Anil K., Deberardinis, Ralph J., Roth, Michael G., Minna, John D. and White, Michael A. (2013). Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell, 155 (3), 552-566. doi: 10.1016/j.cell.2013.09.041

Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer

Kang, Yu, Hu, Wei, Ivan, Cristina, Dalton, Heather J., Miyake, Takahito, Pecot, Chad V., Zand, Behrouz, Liu, Tao, Huang, Jie, Jennings, Nicholas B., Rupaimoole, Rajesha, Taylor, Morgan, Pradeep, Sunila, Wu, Sherry Y., Lu, Chunhua, Wen, Yunfei, Huang, Jianfei, Liu, Jinsong and Sood, Anil K. (2013). Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. JNCI-Journal of the National Cancer Institute, 105 (19), 1485-1495. doi: 10.1093/jnci/djt210

Tumour angiogenesis regulation by the miR-200 family

Pecot, Chad V., Rupaimoole, Rajesha, Yang, Da, Akbani, Rehan, Ivan, Cristina, Lu, Chunhua, Wu, Sherry, Han, Hee-Dong, Shah, Maitri Y., Rodriguez-Aguayo, Cristian, Bottsford-Miller, Justin, Liu, Yuexin, Kim, Sang Bae, Unruh, Anna, Gonzalez-Villasana, Vianey, Huang, Li, Zand, Behrouz, Moreno-Smith, Myrthala, Mangala, Lingegowda S., Taylor, Morgan, Dalton, Heather J., Sehgal, Vasudha, Wen, Yunfei, Kang, Yu, Baggerly, Keith A., Lee, Ju-Seog, Ram, Prahlad T., Ravoori, Murali K., Kundra, Vikas ... Sood, Anil K. (2013). Tumour angiogenesis regulation by the miR-200 family. Nature Communications, 4 (1) 2427. doi: 10.1038/ncomms3427

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis

Masiero, Massimo, Simões, Filipa Costa, Han, Hee Dong, Snell, Cameron, Peterkin, Tessa, Bridges, Esther, Mangala, Lingegowda S., Wu, Sherry Yen-Yao, Pradeep, Sunila, Li, Demin, Han, Cheng, Dalton, Heather, Lopez-Berestein, Gabriel, Tuynman, Jurriaan B., Mortensen, Neil, Li, Ji-Liang, Patient, Roger, Sood, Anil K., Banham, Alison H., Harris, Adrian L. and Buffa, Francesca M. (2013). A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Cancer Cell, 24 (2), 229-241. doi: 10.1016/j.ccr.2013.06.004

Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA

McCaskill, Jana, Singhania, Richa, Burgess, Melinda, Allavena, Rachel, Wu, Sherry, Blumenthal, Antje and McMillan, Nigel A. J. (2013). Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA. Molecular Therapy - Nucleic Acid, 2 (1) e96, e96. doi: 10.1038/mtna.2013.22

The use of lipid-based nanocarriers for targeted pain therapies

Hua, Susan and Wu, Sherry Y. (2013). The use of lipid-based nanocarriers for targeted pain therapies. Frontiers in Pharmacology, 4. doi: 10.3389/fphar.2013.00143

New roles opined for OPCML

Wu, Sherry Y. and Sood, Anil K. (2012). New roles opined for OPCML. Cancer Discovery, 2 (2), 115-116. doi: 10.1158/2159-8290.CD-11-0356

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo

Khairuddin, Norliana, Gantier, Michael P., Blake, Stephen J., Wu, Sherry Y., Behlke, Mark A., Williams, Bryan R. G. and McMillan, Nigel A. J. (2012). siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo. Immunology and Cell Biology, 90 (2), 187-196. doi: 10.1038/icb.2011.19

Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system

Wu, Sherry Y., Chang, Hsin-I, Burgess, Melinda and McMillan, Nigel A. J. (2011). Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system. Journal of Controlled Release, 155 (3), 418-426. doi: 10.1016/j.jconrel.2011.02.002

Effective delivery of PEGylated siRNA-containing Lipoplexes to extraperitoneal tumours following intraperitoneal administration

Singhania, Akul, Wu, Sherry Y. and McMillan, Nigel A. J. (2011). Effective delivery of PEGylated siRNA-containing Lipoplexes to extraperitoneal tumours following intraperitoneal administration. Journal of Drug Delivery, 2011, 192562.1-192562.7. doi: 10.1155/2011/192562

Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models

Wu, S. Y., Singhania, A., Burgess, M., Putral, L. N., Kirkpatrick, C., Davies, N. M. and McMillan, N. A. J. (2011). Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models. Gene Therapy, 18 (1), 14-22. doi: 10.1038/gt.2010.113

Lipidic Systems for In Vivo siRNA Delivery

Wu, SY and McMillan, NAJ (2009). Lipidic Systems for In Vivo siRNA Delivery. AAPS JOURNAL, 11 (4), 639-652. doi: 10.1208/s12248-009-9140-1

Development of a novel method for formulating stable siRNA-loaded lipid particles for In vivo use

Wu, Sherry Y., Putral, Lisa N., Liang, Mingtao, Chang, Hsin-I, Davies, Nigel M. and McMillan, Nigel A.J. (2009). Development of a novel method for formulating stable siRNA-loaded lipid particles for In vivo use. Pharmaceutical Research, 26 (3), 512-522. doi: 10.1007/s11095-008-9766-1

Using action learning to develop a model for inclusive teaching in a COVID-split cohort

Aland, Claire, Oancea, Iulia, Midwinter, Mark, Pillai, Suja, Manchadi, Mary-Louise, Reichelt, Melissa and Wu, Sherry (2022). Using action learning to develop a model for inclusive teaching in a COVID-split cohort. 26th Annual International Association for Medical Science Educators, Denver, CO, United States, 4-7 June 2022.

Molecular analysis of short- vs. long-term ovarian cancer survivors

Stur, Elaine, Dal Molin, Graziela Zibetti, Wu, Sherry, Baggerly, Keith, Tworoger, Shelley, Levine, Douglas, Karlan, Beth, Moore, Kathleen, Lutgendorf, Susan and Sood, Anil (2020). Molecular analysis of short- vs. long-term ovarian cancer survivors. AACR Special Conference on Advances in Ovarian Cancer Research, Atlanta, GA United States, 13-16 September 2019. Philadelphia, PA United States: American Association for Cancer Research.

Evoking potent RNAi response using novel 2 '-OMe-phosphorodithioated modified siRNAs

Wu, Sherry, Yang, Xianbin, Egli, Martin, Ghaupure, Kshipra, Hatakeyama, Hiroto, McGuire, Michael, Rupaimoole, Rajesha, Miyake, Takahito, Taylor, Morgan, Pradeep, Sunila, Nagaraja, Archana, Sierant, Malgorzata, Singhania, Richa, Rodriguez-Aguayo, Cristian, McMillan, Nigel, Lopez-Berestein, Gabriel, Ram, Prahlad, Nawrot, Barbara and Sood, Anil K. (2014). Evoking potent RNAi response using novel 2 '-OMe-phosphorodithioated modified siRNAs. 105th Annual Meeting of the American Association for Cancer Research (AACR), San Diego, CA United States, 05-09 April 2014. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2014-1406