Dr Cuffe Completed his PhD at The University of Queensland before being awarded a competitive research fellowship to Join Griffith University on the Gold Coast. Dr Cuffe returned to UQ in 2018 as a lecturer in the School of Biomedical Sciences and to establish his own research team. Dr Cuffe has a broad range of research interests including investigating early origins of chronic disease, endocrine regulation of fetal development, placental regulation of pregnancy complications and sex differences in basic physiology. He is most recognised for his research in the field of placental biology where he has investigated how maternal perturbations such as stress, hypoxia, altered nutrition or maternal disease all affect placental development and program disease in the mother after pregnancy as well as her offspring. Dr Cuffe has an exceptional track record and is excited to take new honours and PhD students into his research laboratory.
Journal Article: Prenatal choline supplementation alters one carbon metabolites in a rat model of periconceptional alcohol exposure
Steane, Sarah E., Kumar, Vinod, Cuffe, James S. M., Moritz, Karen M. and Akison, Lisa K. (2022). Prenatal choline supplementation alters one carbon metabolites in a rat model of periconceptional alcohol exposure. Nutrients, 14 (9) 1874. doi: 10.3390/nu14091874
Journal Article: Selenium deficiency during pregnancy in mice impairs exercise performance and metabolic function in adult offspring
Hofstee, Pierre, Perkins, Anthony V. and Cuffe, James S. M. (2022). Selenium deficiency during pregnancy in mice impairs exercise performance and metabolic function in adult offspring. Nutrients, 14 (5) 1125, 1125. doi: 10.3390/nu14051125
Journal Article: Maternal hypothyroidism in rats reduces placental lactogen, lowers insulin levels and causes glucose intolerance
Kent, Nykola Louise, Atluri, Sharat Chandra and Cuffe, James Sebastian Martin (2022). Maternal hypothyroidism in rats reduces placental lactogen, lowers insulin levels and causes glucose intolerance. Endocrinology, 163 (2). doi: 10.1210/endocr/bqab231
(2020–2022) Allen Foundation Inc.
(2019) UQ Major Equipment and Infrastructure
(2019) UQ Major Equipment and Infrastructure
The importance of adequate micro nutrient intake for maternal and fetal health during pregnancy
Doctor Philosophy
Understanding the impact of metformin on one carbon metabolism, placental function and fetal outcomes.
Doctor Philosophy
A new the mechanism for the coexistence of hypercortisolaemia and inflammation: GRalpha D1
Doctor Philosophy
Investigating placental contributions to complications of pregnancy
The placenta regulates all aspects of pregnancy health. It secretes factors into the maternal system to control maternal blood glucose concentrations, blood pressure and neurological function. This study will investigate key pathological processes in the placenta which may contribute to gestational diabetes, preeclampsia, preterm birth and intrauterine growth restriction.
Investigating how micro-nutrient deficiencies during pregnancy lead to metabolic and renal disease in offspring.
Given that only 1 in 20 Australians consume the recommended dietary intake of fruit and vegetables, most Australians would be deficient in key micronutrients when they fall pregnant. Deficiencies in these micronutrients is known to increase maternal risk of gestational diabetes and preeclampsia but their influence on offspring physiology is less well understood. This study will investigate the role of specific micronutrients in fetal development and offspring physiology. Most particularly, this project will focus on diabetes and renal disease in offspring, two comorbid conditions known to be affected by events that occur before birth.
The developmental origins of renal dysfunction
Cuffe, James S. M., Walton, Sarah L. and Moritz, Karen M. (2016). The developmental origins of renal dysfunction. The epigenome and developmental origins of health and disease. (pp. 291-314) edited by Cheryl S. Rosenfeld. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-801383-0.00015-3
Steane, Sarah E., Kumar, Vinod, Cuffe, James S. M., Moritz, Karen M. and Akison, Lisa K. (2022). Prenatal choline supplementation alters one carbon metabolites in a rat model of periconceptional alcohol exposure. Nutrients, 14 (9) 1874. doi: 10.3390/nu14091874
Hofstee, Pierre, Perkins, Anthony V. and Cuffe, James S. M. (2022). Selenium deficiency during pregnancy in mice impairs exercise performance and metabolic function in adult offspring. Nutrients, 14 (5) 1125, 1125. doi: 10.3390/nu14051125
Kent, Nykola Louise, Atluri, Sharat Chandra and Cuffe, James Sebastian Martin (2022). Maternal hypothyroidism in rats reduces placental lactogen, lowers insulin levels and causes glucose intolerance. Endocrinology, 163 (2). doi: 10.1210/endocr/bqab231
The effect of gestational age on mitochondrial properties of the mouse placenta
Bartho, Lucy A, Fisher, Joshua J, Walton, Sarah L, Perkins, Anthony V and Cuffe, James S M (2022). The effect of gestational age on mitochondrial properties of the mouse placenta. Reproduction and Fertility, 3 (1), 19-29. doi: 10.1530/raf-21-0064
Developmental vitamin D deficiency in pregnant rats does not induce preeclampsia
Ali, Asad, Alexander, Suzanne, Ko, Pauline, Cuffe, James S. M., Whitehouse, Andrew J. O., McGrath, John J. and Eyles, Darryl (2021). Developmental vitamin D deficiency in pregnant rats does not induce preeclampsia. Nutrients, 13 (12) 4254. doi: 10.3390/nu13124254
Helman, Sheridan L., Wilkins, Sarah J., McKeating, Daniel R, Perkins, Anthony V., Cuffe, James S. M., Hartel, Gunter, Faria, Nuno, Powell, Jonathan J., Anderson, Gregory J. and Frazer, David M. (2021). A Novel Ferritin-Core Analog Is a Safe and Effective Alternative to Oral Ferrous Iron for Treating Iron Deficiency during Pregnancy in Mice. The Journal of Nutrition, 152 (3), 714-722. doi: 10.1093/jn/nxab363
Shrestha, Nirajan, Melvin, Steven D., McKeating, Daniel R., Holland, Olivia J., Cuffe, James S. M., Perkins, Anthony V., McAinch, Andrew J. and Hryciw, Deanne H. (2021). Sex-specific differences in lysine, 3-hydroxybutyric acid and acetic acid in offspring exposed to maternal and postnatal high linoleic acid diet, independent of diet. International Journal of Molecular Sciences, 22 (19) 10223, 1-14. doi: 10.3390/ijms221910223
Bartho, Lucy A., O’Callaghan, Jessica L., Fisher, Joshua J., Cuffe, James S.M., Kaitu'u-Lino, Tu'uhevaha J., Hannan, Natalie J., Clifton, Vicki L. and Perkins, Anthony V. (2021). Analysis of mitochondrial regulatory transcripts in publicly available datasets with validation in placentae from pre-term, post-term and fetal growth restriction pregnancies. Placenta, 112, 162-171. doi: 10.1016/j.placenta.2021.07.303
Meakin, Ashley S., Cuffe, James S. M., Darby, Jack R. T., Morrison, Janna L. and Clifton, Vicki L. (2021). Let’s talk about placental sex, baby: understanding mechanisms that drive female- and male-specific fetal growth and developmental outcomes. International Journal of Molecular Sciences, 22 (12) 6386, 1-17. doi: 10.3390/ijms22126386
The placental ferroxidase zyklopen is not essential for iron transport to the fetus in mice
Helman, Sheridan L., Wilkins, Sarah J., McKeating, Daniel R., Perkins, Anthony V., Whibley, Page E., Cuffe, James S. M., Simmons, David G., Fuqua, Brie K., Vulpe, Christopher D., Wallace, Daniel F., O'Callaghan, Jessica L., Pelzer, Elise S., Anderson, Gregory J. and Frazer, David M. (2021). The placental ferroxidase zyklopen is not essential for iron transport to the fetus in mice. The Journal of Nutrition, 151 (9), 1-10. doi: 10.1093/jn/nxab174
Kent, Nykola L., Young, Sophia L., Akison, Lisa K. and Cuffe, James S. M. (2021). Is the link between elevated TSH and gestational diabetes mellitus dependant on diagnostic criteria and thyroid antibody status: a systematic review and meta-analysis. Endocrine, 74 (1), 38-49. doi: 10.1007/s12020-021-02733-x
Shrestha, Nirajan, Sleep, Simone L., Helman, Tessa J., Holland, Olivia J., Cuffe, James S.M., Perkins, Anthony V., McAinch, Andrew J., Headrick, John P. and Hryciw, Deanne H. (2021). Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model. British Journal of Nutrition, 127 (4), 1-14. doi: 10.1017/S0007114521001276
Shrestha, Nirajan, Vidimce, Josif, Holland, Olivia J., Cuffe, James S. M., Beck, Belinda R., Perkins, Anthony V., McAinch, Andrew J. and Hryciw, Deanne H. (2021). Maternal and postnatal high linoleic acid diet impacts lipid metabolism in adult rat offspring in a sex-specific manner. International Journal of Molecular Sciences, 22 (6) 2946, 1-23. doi: 10.3390/ijms22062946
Neal, Elliott S., Hofstee, Pierre, Askew, Montana R., Kent, Nykola L., Bartho, Lucy A., Perkins, Anthony V. and Cuffe, James S. M. (2021). Maternal selenium deficiency in mice promotes sex‐specific changes to urine flow and renal expression of mitochondrial proteins in adult offspring. Physiological Reports, 9 (6) e14785, 1-14. doi: 10.14814/phy2.14785
Low serum selenium in pregnancy is associated with reduced T3 and increased risk of GDM
Hofstee, Pierre, James-McAlpine, Janelle, McKeating, Daniel R., Vanderlelie, Jessica J., Cuffe, James S.M. and Perkins, Anthony V. (2021). Low serum selenium in pregnancy is associated with reduced T3 and increased risk of GDM. Journal of Endocrinology, 248 (1), 45-57. doi: 10.1530/JOE-20-0319
The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts
Sleep, Simone L., Shrestha, Nirajan, Cuffe, James S. M., Holland, Olivia J., Headrick, John P., McAinch, Andrew J. and Hryciw, Deanne H. (2020). The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts. Journal of Developmental Origins of Health and Disease, 11 (6), 617-622. doi: 10.1017/s2040174419000813
Mitochondrial transformations in the aging human placenta
Bartho, Lucy A., Fisher, Joshua J., Cuffe, James S.M. and Perkins, Anthony V. (2020). Mitochondrial transformations in the aging human placenta. American Journal of Physiology - Endocrinology and Metabolism, 319 (6), E981-E994. doi: 10.1152/AJPENDO.00354.2020
Burgess, Danielle J., Lucia, Diana, Cuffe, James S. M. and Moritz, Karen M. (2020). Periconceptional ethanol exposure alters hypothalamic-pituitary-adrenal axis function, signalling elements and associated behaviours in a rodent model. Psychoneuroendocrinology, 122 104901, 104901. doi: 10.1016/j.psyneuen.2020.104901
Mangwiro, Yeukai T.M., Cuffe, James S.M., Vickers, Mark H., Reynolds, Clare M., Mahizir, Dayana, Anevska, Kristina, Gravina, Sogand, Romano, Tania, Moritz, Karen M., Briffa, Jessica F. and Wlodek, Mary E. (2020). Maternal exercise alters rat fetoplacental stress response: Minimal effects of maternal growth restriction and high-fat feeding. Placenta, 104, 57-70. doi: 10.1016/j.placenta.2020.11.006
Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus
Fisher, Joshua J., Vanderpeet, Chelsea L., Bartho, Lucy A., McKeating, Daniel R., Cuffe, James S. M., Holland, Olivia. J. and Perkins, Anthony V. (2020). Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. The Journal of Physiology, 599 (4) JP280593, 1-15. doi: 10.1113/jp280593
Maternal high linoleic acid alters placental fatty acid composition
Shrestha, Nirajan, Holland, Olivia J., Kent, Nykola L., Perkins, Anthony V., McAinch, Andrew J., Cuffe, James S. M. and Hryciw, Deanne H. (2020). Maternal high linoleic acid alters placental fatty acid composition. Nutrients, 12 (8) 2183, 2183-14. doi: 10.3390/nu12082183
Hofstee, Pierre, Cuffe, James S. M. and Perkins, Anthony V. (2020). Analysis of selenoprotein expression in response to dietary selenium deficiency during pregnancy indicates tissue specific differential expression in mothers and sex specific changes in the fetus and offspring. International Journal of Molecular Sciences, 21 (6) 2210, 2210. doi: 10.3390/ijms21062210
Shrestha, Nirajan, Sleep, Simone L., Cuffe, James S. M., Holland, Olivia J., McAinch, Andrew J., Dekker Nitert, Marloes and Hryciw, Deanne H. (2020). Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet. American Journal of Physiology-Endocrinology and Metabolism, 318 (2), E276-E285. doi: 10.1152/ajpendo.00265.2019
Role of omega-6 and omega-3 fatty acids in fetal programming
Shrestha, Nirajan, Sleep, Simone L., Cuffe, James S. M., Holland, Olivia J., Perkins, Anthony V., Yau, Suk Yu, McAinch, Andrew J. and Hryciw, Deanne H. (2020). Role of omega-6 and omega-3 fatty acids in fetal programming. Clinical and Experimental Pharmacology and Physiology, 47 (5) 1440-1681.13244, 907-915. doi: 10.1111/1440-1681.13244
Hofstee, Pierre, McKeating, Daniel R., Bartho, Lucy A., Anderson, Stephen T., Perkins, Anthony V. and Cuffe, James S. M. (2020). Maternal selenium deficiency in mice alters offspring glucose metabolism and thyroid status in a sexually dimorphic manner. Nutrients, 12 (1) 267, 267. doi: 10.3390/nu12010267
Proteomic Analysis of Placental Mitochondria Following Trophoblast Differentiation
Fisher, Joshua J., McKeating, Daniel R., Cuffe, James S., Bianco-Miotto, Tina, Holland, Olivia J. and Perkins, Anthony V. (2019). Proteomic Analysis of Placental Mitochondria Following Trophoblast Differentiation. Frontiers in Physiology, 10 1536, 1536. doi: 10.3389/fphys.2019.01536
Hofstee, Pierre, Bartho, Lucy A., McKeating, Daniel R., Radenkovic, Filip, McEnroe, Georgia, Fisher, Joshua J., Holland, Olivia J., Vanderlelie, Jessica J., Perkins, Anthony V. and Cuffe, James S.M. (2019). Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth. The Journal of Physiology, 597 (23) JP278473, 5597-5617. doi: 10.1113/jp278473
Shrestha, Nirajan, Cuffe, James S. M., Holland, Olivia J., Bulmer, Andrew C., Hill, Melissa, Perkins, Anthony V., Muhlhausler, Beverly S., McAinch, Andrew J. and Hryciw, Deanne H.. (2019). Elevated maternal linoleic acid reduces circulating leptin concentrations, cholesterol levels and male fetal survival in rat model. The Journal of Physiology, 597 (13) JP277583, 3349-3361. doi: 10.1113/jp277583
Fisher, Joshua J., McKeating, Daniel R., Pennell, Evan N., Cuffe, James S., Holland, Olivia J. and Perkins, Anthony V. (2019). Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta, 82, 1-4. doi: 10.1016/j.placenta.2019.05.004
Bartho, Lucy A., Holland, Olivia, Moritz, Karen M., Perkins, Anthony V. and Cuffe, James S. M. (2019). Maternal corticosterone in the mouse alters oxidative stress markers, antioxidant function and mitochondrial content in placentas of female fetuses. The Journal of Physiology, 597 (12) JP277815, 3053-3067. doi: 10.1113/jp277815
Mangwiro, Yeukai T. M., Cuffe, James S. M., Mahizir, Dayana, Anevska, Kristina, Gravina, Sogand, Romano, Tania, Moritz, Karen M., Briffa, Jessica F. and Wlodek, Mary E. (2019). Exercise initiated during pregnancy in rats born growth restricted alters placental mTOR and nutrient transporter expression. The Journal of Physiology, 597 (7), 1905-1918. doi: 10.1113/jp277227
Shrestha, Nirajan, Cuffe, James S. M., Holland, Olivia J., Perkins, Anthony V., McAinch, Andrew J. and Hryciw, Deanne H. (2019). Linoleic acid increases prostaglandin E2 release and reduces mitochondrial respiration and cell viability in human trophoblast-like cells. Cellular Physiology and Biochemistry, 52 (1), 94-108. doi: 10.33594/000000007
Periconceptional ethanol exposure alters the stress axis in adult female but not male rat offspring
Burgess, Danielle J., Dorey, Emily S., Gardebjer, Emelie M., Bielefeldt-Ohmann, Helle, Moritz, Karen M. and Cuffe, James S. M. (2019). Periconceptional ethanol exposure alters the stress axis in adult female but not male rat offspring. Stress, 22 (3), 1-11. doi: 10.1080/10253890.2018.1563068
Mangwiro, Yeukai T. M., Briffa, Jessica F., Gravina, Sogand, Mahizir, Dayana, Anevska, Kristina, Romano, Tania, Moritz, Karen M., Wlodek, Mary E. and Cuffe, James S. M. (2018). Maternal exercise and growth restriction in rats alters placental angiogenic factors and blood space area in a sex-specific manner. Placenta, 74, 47-54. doi: 10.1016/j.placenta.2018.12.005
Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery
Holland, Olivia J., Cuffe, James S. M., Dekker Nitert, Marloes, Callaway, Leonie, Kwan Cheung, Keith A., Radenkovic, Filip and Perkins, Anthony V. (2018). Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery. Cell Death & Disease, 9 (12) 1150, 1150. doi: 10.1038/s41419-018-1190-9
Placental adaptations to micronutrient dysregulation in the programming of chronic disease
Hofstee, Pierre, McKeating, Daniel R., Perkins, Anthony V. and Cuffe, James S.M. (2018). Placental adaptations to micronutrient dysregulation in the programming of chronic disease. Clinical and Experimental Pharmacology and Physiology, 45 (8), 871-884. doi: 10.1111/1440-1681.12954
Mangwiro, Yeukai T.M., Cuffe, James S.M., Briffa, Jessica F., Mahizir, Dayana, Anevska, Kristina, Jefferies, Andrew J., Hosseini, Sogand, Romano, Tania, Moritz, Karen M. and Wlodek, Mary E. (2018). Maternal exercise in rats upregulates the placental IGF-system with diet and sex-specific responses: minimal effects in mothers born growth restricted. The Journal of Physiology, 596 (23), 5947-5964. doi: 10.1113/jp275758
Peripheral modulation of the endocannabinoid system in metabolic disease
Shrestha, Nirajan, Cuffe, James S. M., Hutchinson, Dana S., Headrick, John P., Perkins, Anthony V., McAinch, Andrew J. and Hryciw, Deanne H. (2018). Peripheral modulation of the endocannabinoid system in metabolic disease. Drug Discovery Today, 23 (3), 592-604. doi: 10.1016/j.drudis.2018.01.029
Uteroplacental insufficiency in rats induces renal apoptosis and delays nephrogenesis completion
Cuffe, James Sm, Briffa, Jessica F., Rosser, Shannyn, Siebel, Andrew L., Romano, Tania, Hryciw, Deanne H., Wlodek, Mary E. and Moritz, Karen M. (2017). Uteroplacental insufficiency in rats induces renal apoptosis and delays nephrogenesis completion. Acta Physiologica, 222 (3) e12982, e12982. doi: 10.1111/apha.12982
Gardebjer, Emelie M., Cuffe, James S. M., Ward, Leigh C., Steane, Sarah, Anderson, Stephen T., Dorey, Emily S., Kalisch-Smith, Jacinta I., Pantaleon, Marie, Chong, Suyinn, Yamada, Lisa, Wlodek, Mary E., Bielefeldt-Ohmann, Helle and Moritz, Karen M. (2017). The effects of periconceptional maternal alcohol intake and a postnatal high-fat diet on obesity and liver disease in male and female rat offspring. American Journal of Physiology: Endocrinology and Metabolism, 315 (4), ajpendo.00251.2-E704. doi: 10.1152/ajpendo.00251.2017
Briffa, Jessica F, Hosseini, Sogand S, Tran, Melanie, Moritz, Karen M, Cuffe, James S M and Wlodek, Mary E (2017). Maternal growth restriction and stress exposure in rats differentially alters expression of components of the placental glucocorticoid barrier and nutrient transporters. Placenta, 59, 30-38. doi: 10.1016/j.placenta.2017.09.006
Dexamethasone and sex regulate placental glucocorticoid receptor isoforms in mice
Cuffe, James S. M., Saif, Zarqa, Perkins, Anthony V., Moritz, Karen M. and Clifton, Vicki L. (2017). Dexamethasone and sex regulate placental glucocorticoid receptor isoforms in mice. Journal of Endocrinology, 234 (2), 89-100. doi: 10.1530/JOE-17-0171
Clifton, V. L., Cuffe, J., Moritz, K. M., Cole, T. J., Fuller, P. J., Lu, N. Z., Kumar, S., Chong, S. and Saif, Z. (2017). Review: The role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth. Placenta, 54, 24-29. doi: 10.1016/j.placenta.2016.12.017
Pantaleon, Marie, Steane, Sarah E., McMahon, Kathryn, Cuffe, James S. M. and Moritz, Karen M. (2017). Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice. Scientific Reports, 7 (1) 2017, 2017. doi: 10.1038/s41598-017-01666-8
Biomarkers of oxidative stress in pregnancy complications
Cuffe, James S. M., Xu, Ziheng Calvin and Perkins, Anthony V. (2017). Biomarkers of oxidative stress in pregnancy complications. Biomarkers in Medicine, 11 (3), 295-306. doi: 10.2217/bmm-2016-0250
Review: Placental derived biomarkers of pregnancy disorders
Cuffe, James S. M., Holland, Olivia, Salomon, Carlos, Rice, Gregory E. and Perkins, Anthony V. (2017). Review: Placental derived biomarkers of pregnancy disorders. Placenta, 54, 104-110. doi: 10.1016/j.placenta.2017.01.119
Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring
Cuffe, J. S. M., Turton, E. L., Akison, L. K., Bielefeldt-Ohmann, H. and Moritz, K. M. (2017). Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring. Journal of Endocrinology, 232 (1), 37-48. doi: 10.1530/JOE-16-0417
Review: Effects of maternal micronutrient supplementation on placental function
Richard, Kerry, Holland, Olivia, Landers, Kelly, Vanderlelie, Jessica J., Hofstee, Pierre, Cuffe, James S. M. and Perkins, Anthony V. (2016). Review: Effects of maternal micronutrient supplementation on placental function. Placenta, 54, 38-44. doi: 10.1016/j.placenta.2016.12.022
Akison, L. K., Andraweera, P. H., Bertoldo, M. J., Brown, H. M., Cuffe, J. S. M., Fullston, T., Holland, O. and Schjenken, J. E. (2016). The current state of reproductive biology research in Australia and New Zealand: core themes from the Society for Reproductive Biology Annual Meeting, 2016. Reproduction, Fertility and Development, 29 (10), 1883-1889. doi: 10.1071/RD16382
Cheong, Jean N., Cuffe, James S. M., Jefferies, Andrew J., Anevska, Kristina, Moritz, Karen and Wlodek, Mary E. (2016). Sex-specific metabolic outcomes in offspring of female rats born small or exposed to stress during pregnancy. Endocrinology, 157 (11), 4104-4120. doi: 10.1210/en.2016-1335
Cheong, Jean N., Cuffe, James S. M., Jefferies, Andrew J., Moritz, Karen M. and Wlodek, Mary E. (2016). Adrenal, metabolic and cardio-renal dysfunction develops after pregnancy in rats born small or stressed by physiological measurements during pregnancy. Journal of Physiology, 594 (20), 6055-6068. doi: 10.1113/JP272212
Cheong, Jean N., Wlodek, Mary E., Moritz, Karen M. and Cuffe, James S. M. (2016). Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations. Journal of Physiology, 594 (17), 4727-4740. doi: 10.1113/JP271745
Spiers, Jereme G., Chen, Hsiao-Jou Cortina, Cuffe, James S. M., Sernia, Corrado and Lavidis, Nickolas A. (2016). Acute restraint stress induces rapid changes in central redox status and protective antioxidant genes in rats. Psychoneuroendocrinology, 67, 104-112. doi: 10.1016/j.psyneuen.2016.02.005
Cuffe, James S. M., Burgess, Danielle J., O'Sullivan, Lee, Singh, Reetu R. and Moritz, Karen M. (2016). Maternal corticosterone exposure in the mouse programs sex-specific renal adaptations in the renin-angiotensin-aldosterone system in 6-month offspring. Physiological Reports, 4 (8) e12754, e12754. doi: 10.14814/phy2.12754
Maternal hypomagnesemia causes placental abnormalities and fetal and postnatal mortality
Schlegel, R. N., Cuffe, J. S. M., Moritz, K. M. and Paravicini, T. M. (2015). Maternal hypomagnesemia causes placental abnormalities and fetal and postnatal mortality. Placenta, 36 (7), 750-758. doi: 10.1016/j.placenta.2015.03.011
O'Sullivan, Lee, Cuffe, James S. M., Koning, Anselm, Singh, Reetu R., Paravicini, Tamara M. and Moritz, Karen M. (2015). Excess prenatal corticosterone exposure results in albuminuria, sex-specific hypotension and altered heart rate responses to restraint stress in aged adult mice. American Journal of Physiology: Renal Physiology, 308 (10), F1065-F1073. doi: 10.1152/ajprenal.00676.2014
Cuffe, James S. M., Steane, Sarah, Moritz, Karen M. and Paravicini, Tamara M. (2015). Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development. PLoS One, 10 (2) e0117978, e0117978. doi: 10.1371/journal.pone.0117978
Cuffe, J. S. M., Walton, S. L., Steane, S. E., Singh, R. R., Simmons, D. G. and Moritz, K. M. (2014). The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Placenta, 35 (11), 953-961. doi: 10.1016/j.placenta.2014.09.004
Cuffe, J. S. M., Walton, S. L, Singh, R. R, Spiers, J. G., Bielefeldt-Ohmann, H., Wilkinson, L., Little, M. H. and Moritz, K. M. (2014). Mid- to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner. The Journal of Physiology, 592 (14), 1-15. doi: 10.1113/jphysiol.2014.272856
Gardebjer E.M., Cuffe J.S.M., Pantaleon M., Wlodek M.E. and Moritz K.M. (2014). Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta. Placenta, 35 (1), 50-57. doi: 10.1016/j.placenta.2013.10.008
The effects of low-moderate dose prenatal ethanol exposure on the fetal and postnatal rat lung
Probyn, M. E., Cuffe, J. S. M., Zanini, S. and Moritz, K. M. (2013). The effects of low-moderate dose prenatal ethanol exposure on the fetal and postnatal rat lung. Journal of Developmental Origins of Health and Disease, 4 (5), 358-367. doi: 10.1017/S2040174413000305
O'Sullivan, Lee, Cuffe, James S. M., Paravicini, Tamara M., Campbell, Sally, Dickinson, Hayley, Singh, Reetu R., Gezmish, Oksan, Black, M. Jane and Moritz, Karen M. (2013). Prenatal exposure to Dexamethasone in the mouse alters cardiac growth patterns and increases pulse pressure in aged male offspring. PLoS One, 8 (7) e69149, e69149.1-e69149.11. doi: 10.1371/journal.pone.0069149
Cuffe, J. S. M., O'Sullivan, L., Simmons, D. S., Anderson, S. T. and Moritz, K. M. (2012). Maternal corticosterone exposure in the mouse has sex-specific effects on placental growth and mRNA expression. Endocrinology, 153 (11), 5500-5511. doi: 10.1210/en.2012-1479
Short and long term effects of exposure to natural and synthetic glucocorticoids during development
Singh, Reetu R., Cuffe, James S.M and Moritz, Karen M. (2012). Short and long term effects of exposure to natural and synthetic glucocorticoids during development. Clinical and Experimental Pharmacology and Physiology, 39 (11), 979-989. doi: 10.1111/1440-1681.12009
Cuffe, J. S. M., Dickinson, H., Simmons, D. G. and Moritz, K. M. (2011). Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse. Placenta, 32 (12), 981-989. doi: 10.1016/j.placenta.2011.09.009
Review: Sex specific programming: A critical role for the renal renin-angiotensin system
Moritz, K. M., Cuffe, J. S M, Wilson, L. B., Dickinson, H., Wlodek, M. E., Simmons, D. G. and Denton, K. M. (2010). Review: Sex specific programming: A critical role for the renal renin-angiotensin system. Placenta, 31 (SUPPL.) doi: 10.1016/j.placenta.2010.01.006
Is placental aging the key to gestational disorders?
Bartho, Lucy, Fisher, Joshua, Holland, Olivia, Cuffe, James and Perkins, Anthony (2019). Is placental aging the key to gestational disorders?. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, Japan, 21-24 September 2018. London, United Kingdom: Elsevier . doi: 10.1016/j.placenta.2019.06.312
Fisher, Joshua, Cuffe, James, Holland, Olivia and Perkins, Anthony (2019). Mmitochondrial metabolic and bioenergetic adaptations associated with the morphological and functional transformation from cytotrophoblast to syncytiotrophoblast. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo, Japan, 21-24 September 2018. London, United Kingdom: Elsevier . doi: 10.1016/j.placenta.2019.06.294
Fisher, Joshua, McKeating, Daniel, Pennell, Evan, Vanderlelie, Jessica, Cuffe, James, Holland, Olivia and Perkins, Anthony (2018). Increased respiration and ATP production in cytotrophoblast compared to syncytiotrophoblast mitochondria. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Tokyo Japan, Sep 21-24, 2018. London, United Kingdom: Elsevier .
Periconceptional ethanol alters the social and depressive-like phenotypes in rat offspring
Burgess, D. J., Lucia, D., Cuffe, J. S. M. and Moritz, K. M. (2018). Periconceptional ethanol alters the social and depressive-like phenotypes in rat offspring. 41st Annual Scientific Meeting of the Research Society on Alcoholism, San Diego, California, 16-20 June 2018 . Malden, MA, United States: Wiley-Blackwell.
Burgess, D. J., Lucia, D., Cuffe, J. S. M. and Moritz, K. M. (2018). Periconceptional ethanol programs a decrease in plasma corticosterone and altered hippocampal gene regulation of stress pathways in rat offspring. 41st Annual Scientific Meeting of the Research Society on Alcoholism, San Diego, CA, United States, 16-20 June 2018. Hoboken, NJ United States: Wiley.
Mangwiro, Yeukai, Cuffe, James, Briffa, Jessica, Hosseini, Sogand, Mahizir, Dayana, Anevska, Kristina, Romano, Tania, Moritz, Karen and Wlodek, Mary (2017). Exercise initiated during pregnancy reduces blood spaces in males, despite increasing placental angiogenic markers. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester England, Aug 30-Sep 2 2017. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2017.07.327
Hofstee, Pierre, Bartho, Lucy A., McKeating, Daniel R., Holland, Olivia J., Vanderlelie, Jessica J., Cuffe, James S. M. and Perkins, Anthony V. (2017). Maternal Selenium Deficiency in Mice Alters Placental Function, Reduces Foetal Glucose Concentrations and Impairs Foetal Growth. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester England, Aug 30-Sep 02, 2017. W B SAUNDERS CO LTD. doi: 10.1016/j.placenta.2017.07.328
Cuffe, James S. M., Bartho, Lucy A., Moritz, Karen M. and Perkins, Tony V. (2017). Maternal corticosterone exposure in the mouse induces placental oxidative stress and dysregulates expression of antioxidant and apoptotic genes in a sex specific manner. The Endocrine Society of Australia Annual Scientific Meeting, Gold Coast, QLD, Australia, 21-24 August 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/cen.13259
Cuffe, S. M. James, Bartho, Lucy A., Holland, Olivia J., Moritz, Karen M. and Perkins, Anthony V. (2017). Maternal glucocorticoid exposure in the mouse alters placental oxidative stress, mitochondrial content and antioxidant capacity in a sexually dimorphic manner. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester England, Aug 30-Sep 2 2017. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2017.07.261
Periconceptional ethanol exposure alters maternal adrenal steroidogenesis and corticosterone levels
Burgess, Danielle, Cuffe, James and Moritz, Karen (2017). Periconceptional ethanol exposure alters maternal adrenal steroidogenesis and corticosterone levels. The Endocrine Society of Australia Annual Scientific Meeting, Gold Coast, QLD, Australia, 21-24 August 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing . doi: 10.1111/cen.13259
Sex-specific placental IGF-system adaptations to maternal exercise in growth restricted mothers
Mangwiro, Yeukai, Cuffe, James, Briffa, Jessica, Mahizir, Dayana, Anevska, Kristina, Romano, Tania, Moritz, Karen and Wlodek, Mary (2017). Sex-specific placental IGF-system adaptations to maternal exercise in growth restricted mothers. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester England, Aug 30-Sep 2 2017. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2017.07.073
Cuffe, James, Saif, Zarqa, Moritz, Karen and Clifton, Vicki (2016). Maternal Dexamethasone Exposure in the Mouse Causes Sex Specific Alterations in the Pattern of Glucocorticoid Receptor Isoform Expression. Meeting of the International-Federation-of-Placenta-Associations (IFPA) - Placenta-Back to the Basics, Portland OR United States, 13-16 September 2016. United Kingdom: Elsevier. doi: 10.1016/j.placenta.2016.06.186
Cuffe, James, Steane, Sarah, McMahon, Kathryn, Moritz, Karen and Pantaleon, Marie (2015). Maternal corticosterone exposure in the mouse causes sex specific alterations in placental OGT and O-linked glycosylation. London, United Kingdom: Elsevier . doi: 10.1016/j.placenta.2015.07.199
Moritz, Karen, Cuffe, James and Simmons, David (2015). Placental Glycogen Deposition: a Cause or Consequence of Impaired Placental Development Contributing to Fetal Growth Restriction?. Unknown, Unknown, Unknown. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2015.07.219
Spiers, Jereme, Chen, Hsiao-Jou Cortina, Cuffe, James, Sernia, Conrad and Lavidis, Nickolas (2015). Restraint stress induces distinct changes in redox status within the hippocampus and striatum accompanied by an up-regulation of protective antioxidant genes. 45th Annual Meeting of the International-Society-of-Psychoneuroendocrinology (ISPNE) on Stress and the Brain - From Fertility to Senility, Edinburgh, Scotland, 08-11 September 2015. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.psyneuen.2015.07.591
Singh, R., Koning, A., O'Sullivan, L., Cuffe, J., Paravicini, T. and Moritz, K. (2013). Reduced Nephron Number But Hypotension in Male Mouse Offspring Following Prenatal Corticosterone Exposure. 49th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Brisbane, QLD Australia, 9-11 September 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12121
O'Sullivan, Lee, Cuffe, James S. M., Campbell, Sally and Moritz, Karen M. (2011). Glucocorticoid specific changes in fetal heart growth and alterations in FGF-2 following prenatal exposure in the mouse. 7th World Congress on Developmental Origins of Health and Disease (DOHaD), Portland, Oregon, United States, 18–21 September 2011. Cambridge, England, U.K.: Cambridge University Press. doi: 10.1017/S204017441100047X
Review: Sex specific programming: A critical role for the renal renin-angiotensin system
Moritz, K.M., Cuffe, J. S., Wilson, L. B., Dickinson, H., Wlodek, M. E., Simmons, D. G. and Denton, K. M. (2010). Review: Sex specific programming: A critical role for the renal renin-angiotensin system. Annual Meeting of the International Federationof Placenta Associations, Adelaide, South Australia, 6-9 October, 2009. London, England: W.B. Saunders. doi: 10.1016/j.placenta.2010.01.006
Maternal glucocorticoid exposure induces sex specific changes in gene expression across generations
Cuffe, J. S. M., Dickinson, H., Boon, W. M. and Moritz, K. M (2009). Maternal glucocorticoid exposure induces sex specific changes in gene expression across generations. 45th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Hobart, TAS, Australia, 7–9 September 2009. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2009.01176.x
Moritz, K., Dickinson, H., Grimmond, S., Gardiner, B., Boon, W-M, Bertram, J., Cullen-Mcewen, L., Cuffe, J., Slattery, C., Poronnik, P. and Caruana, G. (2008). Molecular mechanisms leading to a reduced nephron endowment following prenatal glucocorticoid exposure in the mouse. 44th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Newcastle, Australia, 6-10 September 2008. Richmond, VIC, Australia: Wiley-Blackwell .
The effects of maternal glucocorticoid exposure on the developing placenta
Cuffe, James Sebastian Martin (2012). The effects of maternal glucocorticoid exposure on the developing placenta. PhD Thesis, School of Biomedical Sciences, The University of Queensland.
(2020–2022) Allen Foundation Inc.
(2019) UQ Major Equipment and Infrastructure
(2019) UQ Major Equipment and Infrastructure
Placental clock gene expression in the Spiny Mouse
(2012) UWA-UQ Bilateral Research Collaboration Award
The importance of adequate micro nutrient intake for maternal and fetal health during pregnancy
Doctor Philosophy — Principal Advisor
Other advisors:
Understanding the impact of metformin on one carbon metabolism, placental function and fetal outcomes.
Doctor Philosophy — Principal Advisor
Other advisors:
A new the mechanism for the coexistence of hypercortisolaemia and inflammation: GRalpha D1
Doctor Philosophy — Associate Advisor
Other advisors:
Glycogen in Epilepsy
Doctor Philosophy — Associate Advisor
Other advisors:
The effect of alcohol exposure on maternal, placental and fetal micronutrients
Doctor Philosophy — Associate Advisor
Other advisors:
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Investigating placental contributions to complications of pregnancy
The placenta regulates all aspects of pregnancy health. It secretes factors into the maternal system to control maternal blood glucose concentrations, blood pressure and neurological function. This study will investigate key pathological processes in the placenta which may contribute to gestational diabetes, preeclampsia, preterm birth and intrauterine growth restriction.
Investigating how micro-nutrient deficiencies during pregnancy lead to metabolic and renal disease in offspring.
Given that only 1 in 20 Australians consume the recommended dietary intake of fruit and vegetables, most Australians would be deficient in key micronutrients when they fall pregnant. Deficiencies in these micronutrients is known to increase maternal risk of gestational diabetes and preeclampsia but their influence on offspring physiology is less well understood. This study will investigate the role of specific micronutrients in fetal development and offspring physiology. Most particularly, this project will focus on diabetes and renal disease in offspring, two comorbid conditions known to be affected by events that occur before birth.