The University of Queensland

Redefining the bacterial Type I protein secretion system

Hodges, Freya J., Torres, Von Vergel L., Cunningham, Adam F., Henderson, Ian R. and Icke, Christopher (2022). Redefining the bacterial Type I protein secretion system. Advances in microbial physiology. (pp. 1-50) San Diego, CA, United States: Academic Press. doi: 10.1016/bs.ampbs.2022.10.003

Type 1 and 5 secretion systems and associated toxins

Wells, Timothy J. and Henderson, Ian R. (2013). Type 1 and 5 secretion systems and associated toxins. Escherichia coli: pathotypes and principles of pathogenesis. (pp. 499-532) edited by Michael S. Donnenberg. Cambridge, MA, United States: Academic Press. doi: 10.1016/B978-0-12-397048-0.00016-4

Cycles of satellite and transposon evolution in Arabidopsis centromeres

Wlodzimierz, Piotr, Rabanal, Fernando A., Burns, Robin, Naish, Matthew, Primetis, Elias, Scott, Alison, Mandáková, Terezie, Gorringe, Nicola, Tock, Andrew J., Holland, Daniel, Fritschi, Katrin, Habring, Anette, Lanz, Christa, Patel, Christie, Schlegel, Theresa, Collenberg, Maximilian, Mielke, Miriam, Nordborg, Magnus, Roux, Fabrice, Shirsekar, Gautam, Alonso-Blanco, Carlos, Lysak, Martin A., Novikova, Polina Y., Bousios, Alexandros, Weigel, Detlef and Henderson, Ian R. (2023). Cycles of satellite and transposon evolution in Arabidopsis centromeres. Nature, 618 (7965), 557-565. doi: 10.1038/s41586-023-06062-z

Antibiotics in the clinical pipeline as of December 2022

Butler, Mark S., Henderson, Ian R., Capon, Robert J. and Blaskovich, Mark A. T. (2023). Antibiotics in the clinical pipeline as of December 2022. The Journal of Antibiotics, 76 (8), 431-473. doi: 10.1038/s41429-023-00629-8

TRASH: Tandem Repeat Annotation and Structural Hierarchy

Wlodzimierz, Piotr, Hong, Michael and Henderson, Ian R. (2023). TRASH: Tandem Repeat Annotation and Structural Hierarchy. Bioinformatics, 39 (5) btad308. doi: 10.1093/bioinformatics/btad308

A multiomic approach to defining the essential genome of the globally important pathogen Corynebacterium diphtheriae

Goodall, Emily C. A., Azevedo Antunes, Camila, Möller, Jens, Sangal, Vartul, Torres, Von Vergel L., Gray, Jessica, Cunningham, Adam F., Hoskisson, Paul A., Burkovski, Andreas and Henderson, Ian R. (2023). A multiomic approach to defining the essential genome of the globally important pathogen Corynebacterium diphtheriae. PLOS Genetics, 19 (4) e1010737, e1010737. doi: 10.1371/journal.pgen.1010737

Salmonella infection induces the reorganization of follicular dendritic cell networks concomitant with the failure to generate germinal centers

Marcial-Juárez, Edith, Pérez-Toledo, Marisol, Nayar, Saba, Pipi, Elena, Alshayea, Areej, Persaud, Ruby, Jossi, Sian E., Lamerton, Rachel, Barone, Francesca, Henderson, Ian R. and Cunningham, Adam F. (2023). Salmonella infection induces the reorganization of follicular dendritic cell networks concomitant with the failure to generate germinal centers. iScience, 26 (4) 106310, 1-22. doi: 10.1016/j.isci.2023.106310

Efficient Autotransporter-Mediated Extracellular Secretion of a Heterologous Recombinant Protein by Escherichia coli

Beriotto, Irene, Icke, Christopher, Sevastsyanovich, Yanina R., Rossiter, Amanda E., Romagnoli, Giacomo, Savino, Silvana, Hodges, Freya J., Cole, Jeffrey A., Saul, Allan, MacLennan, Calman A., Cunningham, Adam F., Micoli, Francesca and Henderson, Ian R. (2023). Efficient Autotransporter-Mediated Extracellular Secretion of a Heterologous Recombinant Protein by Escherichia coli. Microbiology Spectrum, 11 (3). doi: 10.1128/spectrum.03594-22

Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses

Jossi, Siân E., Arcuri, Melissa, Alshayea, Areej, Persaud, Ruby R., Marcial-Juárez, Edith, Palmieri, Elena, Di Benedetto, Roberta, Pérez-Toledo, Marisol, Pillaye, Jamie, Channell, Will M., Schager, Anna E., Lamerton, Rachel E., Cook, Charlotte N., Goodall, Margaret, Haneda, Takeshi, Bäumler, Andreas J., Jackson-Jones, Lucy H., Toellner, Kai-Michael, MacLennan, Calman A., Henderson, Ian R., Micoli, Francesca and Cunningham, Adam F. (2023). Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses. Frontiers in Immunology, 14 1139329. doi: 10.3389/fimmu.2023.1139329

Genome-wide analysis of Antigen 43 (Ag43) variants: new insights in their diversity, distribution and prevalence in bacteria

Ageorges, Valentin, Wawrzyniak, Ivan, Ruiz, Philippe, Bicep, Cédric, Zorgani, Mohamed A., Paxman, Jason J., Heras, Begoña, Henderson, Ian R., Leroy, Sabine, Bailly, Xavier, Sapountzis, Panagiotis, Peyretaillade, Eric and Desvaux, Mickaël (2023). Genome-wide analysis of Antigen 43 (Ag43) variants: new insights in their diversity, distribution and prevalence in bacteria. International Journal of Molecular Sciences, 24 (6) 5500, 1-24. doi: 10.3390/ijms24065500

Natural products as anthelmintics: safeguarding animal health

Salim, Angela A., Butler, Mark S., Blaskovich, Mark A. T., Henderson, Ian R. and Capon, Robert J. (2023). Natural products as anthelmintics: safeguarding animal health. Natural Product Reports. doi: 10.1039/d3np00019b

Non-caloric artificial sweeteners modulate conjugative transfer of multi-drug resistance plasmid in the gut microbiota

Yu, Zhigang, Henderson, Ian R. and Guo, Jianhua (2022). Non-caloric artificial sweeteners modulate conjugative transfer of multi-drug resistance plasmid in the gut microbiota. Gut Microbes, 15 (1) 2157698, 1-15. doi: 10.1080/19490976.2022.2157698

A method for increasing electroporation competence of Gram-negative clinical isolates by polymyxin B nonapeptide

Qin, Jilong, Hong, Yaoqin, Pullela, Karthik, Morona, Renato, Henderson, Ian R. and Totsika, Makrina (2022). A method for increasing electroporation competence of Gram-negative clinical isolates by polymyxin B nonapeptide. Scientific Reports, 12 (1) 11629, 1-8. doi: 10.1038/s41598-022-15997-8

Plasmids can shift bacterial morphological response against antibiotic stress

Yu, Zhigang, Goodall, Emily C. A., Henderson, Ian R. and Guo, Jianhua (2022). Plasmids can shift bacterial morphological response against antibiotic stress. Advanced Science, 10 (2) 2203260, 1-12. doi: 10.1002/advs.202203260

Transposon-directed insertion-site sequencing reveals glycolysis gene gpmA as part of the H2O2 defense mechanisms in Escherichia coli

Roth, Myriam, Goodall, Emily C. A., Pullela, Karthik, Jaquet, Vincent, François, Patrice, Henderson, Ian R. and Krause, Karl-Heinz (2022). Transposon-directed insertion-site sequencing reveals glycolysis gene gpmA as part of the H2O2 defense mechanisms in Escherichia coli. Antioxidants, 11 (10) 2053, 1-19. doi: 10.3390/antiox11102053

LI-detector: a method for curating ordered gene-replacement libraries

Goodall, Emily C. A., Morris, Faye C., McKeand, Samantha A., Sullivan, Rudi, Warner, Isabel A., Sheehan, Emma, Boelter, Gabriela, Icke, Christopher, Cunningham, Adam F., Cole, Jeffrey A., Banzhaf, Manuel, Bryant, Jack A. and Henderson, Ian R. (2022). LI-detector: a method for curating ordered gene-replacement libraries. Microbiology Spectrum, 10 (4) e0083322, 1-12. doi: 10.1128/spectrum.00833-22

SARS-CoV-2 spike- and nucleoprotein-specific antibodies induced after vaccination or infection promote classical complement activation

Lamerton, Rachel E., Marcial-Juarez, Edith, Faustini, Sian E., Perez-Toledo, Marisol, Goodall, Margaret, Jossi, Siân E., Newby, Maddy L., Chapple, Iain, Dietrich, Thomas, Veenith, Tonny, Shields, Adrian M., Harper, Lorraine, Henderson, Ian R., Rayes, Julie, Wraith, David C., Watson, Steve P., Crispin, Max, Drayson, Mark T., Richter, Alex G. and Cunningham, Adam F. (2022). SARS-CoV-2 spike- and nucleoprotein-specific antibodies induced after vaccination or infection promote classical complement activation. Frontiers in Immunology, 13 838780, 1-13. doi: 10.3389/fimmu.2022.838780

The lipoprotein DolP affects cell separation in Escherichia coli, but not as an upstream regulator of NlpD

Boelter, Gabriela, Bryant, Jack A., Doherty, Hannah, Wotherspoon, Peter, Alodaini, Dema, Ma, Xuyu, Alao, Micheal B., Moynihan, Patrick J., Moradigaravand, Danesh, Glinkowska, Monika, Knowles, Timothy J., Henderson, Ian R. and Banzhaf, Manuel (2022). The lipoprotein DolP affects cell separation in Escherichia coli, but not as an upstream regulator of NlpD. Microbiology, 168 (5) 001197, 1-10. doi: 10.1099/mic.0.001197

Secreted autotransporter toxin (Sat) mediates innate immune system evasion

Freire, Claudia A., Silva, Rosa M., Ruiz, Rita C., Pimenta, Daniel C., Bryant, Jack A., Henderson, Ian R., Barbosa, Angela S. and Elias, Waldir P. (2022). Secreted autotransporter toxin (Sat) mediates innate immune system evasion. Frontiers in Immunology, 13 844878, 844878. doi: 10.3389/fimmu.2022.844878

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

Goodall, Emily C. A., Isom, Georgia L., Rooke, Jessica L., Pullela, Karthik, Icke, Christopher, Yang, Zihao, Boelter, Gabriela, Jones, Alun, Warner, Isabel, Da Costa, Rochelle, Zhang, Bing, Rae, James, Tan, Wee Boon, Winkle, Matthias, Delhaye, Antoine, Heinz, Eva, Collet, Jean-Francois, Cunningham, Adam F., Blaskovich, Mark A., Parton, Robert G., Cole, Jeff A., Banzhaf, Manuel, Chng, Shu-Sin, Vollmer, Waldemar, Bryant, Jack A. and Henderson, Ian R. (2021). Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth. PLoS Genetics, 17 (12) e1009586, 1-40. doi: 10.1371/journal.pgen.1009586

Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation

Yu, Zhigang, Wang, Yue, Henderson, Ian R. and Guo, Jianhua (2021). Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation. The ISME Journal, 16 (2), 1-12. doi: 10.1038/s41396-021-01095-6

Anti-LPS IgA and IgG can inhibit serum killing of Pseudomonas aeruginosa in patients with cystic fibrosis

Pham, Amy, Ledger, Emma L., Coggon, Carrie F., Henderson, Ian R., Reid, David W., Bell, Scott C., Smith, Daniel J. and Wells, Timothy J. (2021). Anti-LPS IgA and IgG can inhibit serum killing of Pseudomonas aeruginosa in patients with cystic fibrosis. Infection and Immunity, 89 (12) e00412-21, e0041221. doi: 10.1128/iai.00412-21

DpaA detaches Braun’s lipoprotein from peptidoglycan

Winkle, Matthias, Hernández-Rocamora, Víctor M., Pullela, Karthik, Goodall, Emily C. A., Martorana, Alessandra M., Gray, Joe, Henderson, Ian R., Polissi, Alessandra and Vollmer, Waldemar (2021). DpaA detaches Braun’s lipoprotein from peptidoglycan. mBio, 12 (3) e00836-21. doi: 10.1128/mbio.00836-21

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

Icke, Christopher, Hodges, Freya J., Pullela, Karthik, McKeand, Samantha A., Bryant, Jack Alfred, Cunningham, Adam F., Cole, Jeff A. and Henderson, Ian R. (2021). Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system. eLife, 10 e63762, 1-24. doi: 10.7554/elife.63762

BamA and BamD are essential for the secretion of trimeric autotransporter adhesins

Rooke, Jessica L., Icke, Christopher, Wells, Timothy J, Rossiter, Amanda E., Browning, Douglas F., Morris, Faye C., Leo, Jack C., Schütz, Monika S., Autenrieth, Ingo B., Cunningham, Adam F., Linke, Dirk and Henderson, Ian R. (2021). BamA and BamD are essential for the secretion of trimeric autotransporter adhesins. Frontiers in Microbiology, 12 628879, 1-10. doi: 10.3389/fmicb.2021.628879

Evolution and plasticity of genome-wide meiotic recombination rates

Henderson, Ian R. and Bomblies, Kirsten (2021). Evolution and plasticity of genome-wide meiotic recombination rates. Annual Review of Genetics, 55 (1), 23-43. doi: 10.1146/annurev-genet-021721-033821

Structure-function characterization of the conserved regulatory mechanism of the Escherichia coli M48-metalloprotease BepA

Bryant, Jack A., Cadby, Ian T., Chong, Zhi-Soon, Boelter, Gabriela, Sevastsyanovich, Yanina R., Morris, Faye C., Cunningham, Adam F., Kritikos, George, Meek, Richard W., Banzhaf, Manuel, Chng, Shu-Sin, Lovering, Andrew L. and Henderson, Ian R. (2021). Structure-function characterization of the conserved regulatory mechanism of the Escherichia coli M48-metalloprotease BepA. Journal of Bacteriology, 203 (2) e00434-20, e00434-20. doi: 10.1128/jb.00434-20

Structure of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localization

Bryant, Jack Alfred, Morris, Faye C., Knowles, Timothy J., Maderbocus, Riyaz, Heinz, Eva, Boelter, Gabriela, Alodaini, Dema, Colyer, Adam, Wotherspoon, Peter J., Staunton, Kara A., Jeeves, Mark, Browning, Douglas F., Sevastsyanovich, Yanina R., Wells, Timothy J., Rossiter, Amanda E., Bavro, Vassiliy N., Sridhar, Pooja, Ward, Douglas G., Chong, Zhi-Soon, Goodall, Emily C. A., Icke, Christopher, Teo, Alvin, Chng, Shu-Sin, Roper, David I., Lithgow, Trevor, Cunningham, Adam F., Banzhaf, Manuel, Overduin, Michael and Henderson, Ian R. (2020). Structure of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localization. eLife, 9 e62614, 1-61. doi: 10.7554/elife.62614

Mice deficient in T-bet form inducible NO synthase-positive granulomas that fail to constrain Salmonella

Perez-Toledo, Marisol, Beristain-Covarrubias, Nonantzin, Channell, William M., Hitchcock, Jessica R., Cook, Charlotte N., Coughlan, Ruth E., Bobat, Saeeda, Jones, Nicholas D., Nakamura, Kyoko, Ross, Ewan A., Rossiter, Amanda E., Rooke, Jessica, Garcia-Gimenez, Alicia, Jossi, Sian, Persaud, Ruby R., Marcial-Juarez, Edith, Flores-Langarica, Adriana, Henderson, Ian R., Withers, David R., Watson, Steve P. and Cunningham, Adam F. (2020). Mice deficient in T-bet form inducible NO synthase-positive granulomas that fail to constrain Salmonella. Journal of Immunology, 205 (3), 708-719. doi: 10.4049/jimmunol.2000089

Iron is a ligand of SecA-like metal-binding domains in vivo

Cranford-Smith, Tamar, Jamshad, Mohammed, Jeeves, Mark, Chandler, Rachael A., Yule, Jack, Robinson, Ashley, Alam, Farhana, Dunne, Karl A., Aponte Angarita, Edwin H., Alanazi, Mashael, Carter, Cailean, Henderson, Ian R., Lovett, Janet E., Winn, Peter, Knowles, Timothy and Huber, Damon (2020). Iron is a ligand of SecA-like metal-binding domains in vivo. Journal of Biological Chemistry, 295 (21), jbc.RA120.012611-7528. doi: 10.1074/jbc.ra120.012611

Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface

Domínguez-Medina, C. Coral, Pérez-Toledo, Marisol, Schager, Anna E., Marshall, Jennifer L., Cook, Charlotte N., Bobat, Saeeda, Hwang, Hyea, Chun, Byeong Jae, Logan, Erin, Bryant, Jack A., Channell, Will M., Morris, Faye C., Jossi, Sian E., Alshayea, Areej, Rossiter, Amanda E., Barrow, Paul A., Horsnell, William G., MacLennan, Calman A., Henderson, Ian R., Lakey, Jeremy H., Gumbart, James C., López-Macías, Constantino, Bavro, Vassiliy N. and Cunningham, Adam F. (2020). Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface. Nature Communications, 11 (1) 851, 851. doi: 10.1038/s41467-020-14655-9

Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway

Benedikz, Elizabeth K., Bailey, Dalan, Cook, Charlotte N. L., Gonçalves-Carneiro, Daniel, Buckner, Michelle M. C., Blair, Jessica M. A., Wells, Timothy J., Fletcher, Nicola F., Goodall, Margaret, Flores-Langarica, Adriana, Kingsley, Robert A., Madsen, Jens, Teeling, Jessica, Johnston, Sebastian L., MacLennan, Calman A., Balfe, Peter, Henderson, Ian R., Piddock, Laura J. V., Cunningham, Adam F. and McKeating, Jane A. (2019). Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway. Scientific Reports, 9 (1) 7903. doi: 10.1038/s41598-019-44263-7

Understanding infection-induced thrombosis: lessons learned from animal models

Beristain-Covarrubias, Nonantzin, Perez-Toledo, Marisol, Thomas, Mark R., Henderson, Ian R., Watson, Steve P. and Cunningham, Adam F. (2019). Understanding infection-induced thrombosis: lessons learned from animal models. Frontiers in Immunology, 10 2569, 2569. doi: 10.3389/fimmu.2019.02569

Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system

Hughes, Gareth W., Hall, Stephen C. L., Laxton, Claire S., Sridhar, Pooja, Mahadi, Amirul H., Hatton, Caitlin, Piggot, Thomas J., Wotherspoon, Peter J., Leney, Aneika C., Ward, Douglas G., Jamshad, Mohammed, Spana, Vaclav, Cadby, Ian T., Harding, Christopher, Isom, Georgia L., Bryant, Jack A., Parr, Rebecca J., Yakub, Yasin, Jeeves, Mark, Huber, Damon, Henderson, Ian R., Clifton, Luke A., Lovering, Andrew L. and Knowles, Timothy J. (2019). Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system. Nature Microbiology, 4 (10), 1692-1705. doi: 10.1038/s41564-019-0481-y

Complete genome sequence of Helicobacter pylori B128 7.13 and a single-step method for the generation of unmarked mutations

Dawson, Emma M., Dunne, Karl A., Richardson, Emily J., Praszkier, Judyta, Alfawaz, Dana, Woelfel, Simon, De Paoli, Amanda, Chaudhry, Hassan, Henderson, Ian R., Ferrero, Richard L. and Rossiter, Amanda E. (2019). Complete genome sequence of Helicobacter pylori B128 7.13 and a single-step method for the generation of unmarked mutations. Helicobacter, 24 (4) e12587, e12587. doi: 10.1111/hel.12587

Differential homotypic and heterotypic interactions of antigen 43 (Ag43) variants in autotransporter-mediated bacterial autoaggregation

Ageorges, Valentin, Schiavone, Marion, Jubelin, Gregory, Caccia, Nelly, Ruiz, Philippe, Chafsey, Ingrid, Bailly, Xavier, Dague, Etienne, Leroy, Sabine, Paxman, Jason, Heras, Begona, Chaucheyras-Durand, Frederique, Rossiter, Amanda E., Henderson, Ian R. and Desvaux, Mickael (2019). Differential homotypic and heterotypic interactions of antigen 43 (Ag43) variants in autotransporter-mediated bacterial autoaggregation. Scientific Reports, 9 (1) 11100, 11100. doi: 10.1038/s41598-019-47608-4

The Type III Secretion System (T3SS)-Translocon of Atypical Enteropathogenic Escherichia coli (aEPEC) Can Mediate Adherence

Santos, Fernanda F., Yamamoto, Denise, Abe, Cecilia M., Bryant, Jack A., Hernandes, Rodrigo T., Kitamura, Felipe C., Castro, Felipe S., Valiatti, Tiago B., Piazza, Roxane M. F., Elias, Waldir P., Henderson, Ian R. and Gomes, Tania A. T. (2019). The Type III Secretion System (T3SS)-Translocon of Atypical Enteropathogenic Escherichia coli (aEPEC) Can Mediate Adherence. Frontiers in Microbiology, 10 (July) 1527. doi: 10.3389/fmicb.2019.01527

Organization and architecture of AggR-dependent promoters from Enteroaggregative Escherichia coli

Yasir, Muhammad, Icke, Christopher, Abdelwahab, Radwa, Haycocks, James R, Godfrey, Rita E, Sazinas, Pavelas, Pallen, Mark J, Henderson, Ian R, Busby, Stephen J W and Browning, Douglas F (2019). Organization and architecture of AggR-dependent promoters from Enteroaggregative Escherichia coli. Molecular microbiology, 111 (2), 534-551. doi: 10.1111/mmi.14172

Salmonella enterica serovar typhimurium travels to mesenteric lymph nodes both with host cells and autonomously

Bravo-Blas, Alberto, Utriainen, Lotta, Clay, Slater L., Kästele, Verena, Cerovic, Vuk, Cunningham, Adam F., Henderson, Ian R., Wall, Daniel M. and Milling, Simon W. F. (2019). Salmonella enterica serovar typhimurium travels to mesenteric lymph nodes both with host cells and autonomously. Journal of Immunology, 202 (1), 260-267. doi: 10.4049/jimmunol.1701254

Draft whole-genome sequences of 10 atypical enteropathogenic Escherichia coli strains isolated in Brazil

Santos, Fernanda F., Richardson, Emily J., Bryant, Jack A., Yamamoto, Denise, Elias, Waldir P., Gomes, Tânia A.T. and Henderson, Ian R. (2018). Draft whole-genome sequences of 10 atypical enteropathogenic Escherichia coli strains isolated in Brazil. Microbiology Resource Announcements, 7 (22) e01432-18. doi: 10.1128/MRA.01432-18

Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps

Beristain-Covarrubias, Nonantzin, Perez-Toledo, Marisol, Flores-Langarica, Adriana, Zuidscherwoude, Malou, Hitchcock, Jessica R., Channell, Will M., King, Lloyd D. W., Thomas, Mark R., Henderson, Ian R., Rayes, Julie, Watson, Steve P. and Cunningham, Adam F. (2018). Salmonella-induced thrombi in mice develop asynchronously in the spleen and liver and are not effective bacterial traps. Blood, 133 (6), 600-604. doi: 10.1182/blood-2018-08-867267

YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium

Morris, Faye C., Wells, Timothy J., Bryant, Jack A., Schager, Anna E., Sevastsyanovich, Yanina R., Squire, Derrick J. P., Marshall, Jennifer, Isom, Georgia L., Rooke, Jessica, Maderbocus, Riyaz, Knowles, Timothy J., Overduin, Michael, Rossiter, Amanda E., Cunningham, Adam F. and Henderson, Ian R. (2018). YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium. Infection and Immunity, 86 (11) e00829-17. doi: 10.1128/IAI.00829-17

Intestinal CD103+CD11b+ cDC2 conventional dendritic cells are required for primary CD4+ T and B cell responses to soluble flagellin

Flores-Langarica, Adriana, Cook, Charlotte, Müller Luda, Katarzyna, Persson, Emma K., Marshall, Jennifer L., Beristain-Covarrubias, Nonantzin, Yam-Puc, Juan Carlos, Dahlgren, Madelene, Persson, Jenny J., Uematsu, Satoshi, Akira, Shizuo, Henderson, Ian R., Lindbom, Bengt Johansson, Agace, William and Cunningham, Adam F. (2018). Intestinal CD103+CD11b+ cDC2 conventional dendritic cells are required for primary CD4+ T and B cell responses to soluble flagellin. Frontiers in Immunology, 9 (OCT) 2409. doi: 10.3389/fimmu.2018.02409

FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants

Grinter, Rhys, Hay, Iain D., Song, Jiangning, Wang, Jiawei, Teng, Don, Dhanesakaran, Vijay, Wilksch, Jonathan J., Davies, Mark R., Littler, Dene, Beckham, Simone A., Henderson, Ian R., Strugnell, Richard A., Dougan, Gordon and Lithgow, Trevor (2018). FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants. PLoS biology, 16 (8) e2006026, e2006026. doi: 10.1371/journal.pbio.2006026

A novel method of serum resistance by Escherichia coli that causes urosepsis

Coggon, Carrie F., Jiang, Andrew, Goh, Kelvin G. K., Henderson, Ian R., Schembri, Mark A. and Wells, Timothy J. (2018). A novel method of serum resistance by Escherichia coli that causes urosepsis. mBio, 9 (3) e00920-18, e00920-18. doi: 10.1128/mbio.00920-18

CD103 + CD11b + mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin

Flores-Langarica, A., Müller Luda, K., Persson, E. K., Cook, C. N., Bobat, S., Marshall, J. L., Dahlgren, M. W., Hägerbrand, K., Toellner, K. M., Goodall, M. D., Withers, D. R., Henderson, I. R., Johansson Lindbom, B., Cunningham, A. F. and Agace, W. W. (2018). CD103 + CD11b + mucosal classical dendritic cells initiate long-term switched antibody responses to flagellin. Mucosal Immunology, 11 (3), 681-692. doi: 10.1038/mi.2017.105

Molecular basis for the folding of β-helical autotransporter passenger domains

Yuan, Xiaojun, Johnson, Matthew D., Zhang, Jing, Lo, Alvin W., Schembri, Mark A., Wijeyewickrema, Lakshmi C., Pike, Robert N., Huysmans, Gerard H. M., Henderson, Ian R. and Leyton, Denisse L. (2018). Molecular basis for the folding of β-helical autotransporter passenger domains. Nature Communications, 9 (1) 1395, 1395. doi: 10.1038/s41467-018-03593-2

Humoral immunity to memory antigens and pathogens is maintained in patients with chronic kidney disease

Wall, Nadezhda A., Coral Dominguez-Medina, C., Faustini, Sian E., Cook, Charlotte N., McClean, Andrew, Jesky, Mark D., Perez-Toledo, Marisol, Morgan, Matthew D., Richter, Alexandra G., Ferro, Charles J., Cockwell, Paul, Moss, Paul A., Henderson, Ian R., Harper, Lorraine and Cunningham, Adam F. (2018). Humoral immunity to memory antigens and pathogens is maintained in patients with chronic kidney disease. PLoS ONE, 13 (4) e0195730, e0195730. doi: 10.1371/journal.pone.0195730

Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella

Hammarlof, Disa L., Kroger, Carsten, Owen, Sian V., Canals, Rocio, Lacharme-Lora, Lizeth, Wenner, Nicolas, Schager, Anna E., Wells, Timothy J., Henderson, Ian R., Wigley, Paul, Hokamp, Karsten, Feasey, Nicholas A., Gordon, Melita A. and Hinton, Jay C. D. (2018). Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella. Proceedings of the National Academy of Sciences of the United States of America, 115 (11), E2614-E2623. doi: 10.1073/pnas.1714718115

IgG responses to porins and lipopolysaccharide within an outer membrane-based vaccine against nontyphoidal Salmonella develop at discordant rates

Schager, Anna E., Dominguez-Medina, C. Coral, Necchi, Francesca, Micoli, Francesca, Goh, Yun Shan, Goodall, Margaret, Flores-Langarica, Adriana, Bobat, Saeeda, Cook, Charlotte N. L., Arcuri, Melissa, Marini, Arianna, King, Lloyd D. W., Morris, Faye C., Anderson, Graham, Toellner, Kai-Michael, Henderson, Ian R., López-Macías, Constantino, MacLennan, Calman A. and Cunningham, Adam F. (2018). IgG responses to porins and lipopolysaccharide within an outer membrane-based vaccine against nontyphoidal Salmonella develop at discordant rates. mBio, 9 (2) e02379-17. doi: 10.1128/mBio.02379-17

The essential genome of Escherichia coli K-12

Goodall, Emily C. A., Robinson, Ashley, Johnston, Iain G., Jabbari, Sara, Turner, Keith A., Cunningham, Adam F., Lund, Peter A., Cole, Jeffrey A. and Henderson, Ian R. (2018). The essential genome of Escherichia coli K-12. mBio, 9 (1) e02096-17. doi: 10.1128/mBio.02096-17

Complete closed genome sequence of nontoxigenic invasive Corynebacterium diphtheriae bv. mitis strain ISS 3319

Antunes, Camila Azevedo, Richardson, Emily J., Quick, Joshua, Fuentes-Utrilla, Pablo, Isom, Georgia L., Goodall, Emily C., Möller, Jens, Hoskisson, Paul A., Mattos-Guaraldi, Ana Luiza, Cunningham, Adam F., Loman, Nicholas J., Sangal, Vartul, Burkovski, Andreas and Henderson, Ian R. (2018). Complete closed genome sequence of nontoxigenic invasive Corynebacterium diphtheriae bv. mitis strain ISS 3319. Genome Announcements, 6 (5) e01566-17. doi: 10.1128/genomeA.01566-17

Identification of the autochaperone domain in the type va secretion system (T5aSS): prevalent feature of autotransporters with a β-helical passenger

Rojas-Lopez, Maricarmen, Zorgani, Mohamed A., Kelley, Lawrence A., Bailly, Xavier, Kajava, Andrey V., Henderson, Ian R., Polticelli, Fabio, Pizza, Mariagrazia, Rosini, Roberto and Desvaux, Mickaël (2018). Identification of the autochaperone domain in the type va secretion system (T5aSS): prevalent feature of autotransporters with a β-helical passenger. Frontiers in Microbiology, 8 (JAN) 2607. doi: 10.3389/fmicb.2017.02607

Antigen localization influences the magnitude and kinetics of endogenous adaptive immune response to recombinant Salmonella vaccines

Sevastsyanovich, Yanina R., Withers, David R., Marriott, Claire L., Morris, Faye C., Wells, Timothy J., Browning, Douglas F., Beriotto, Irene, Ross, Ewan, Ali, Hossam Omar, Wardius, Catherine A., Cunningham, Adam F., Henderson, Ian R. and Rossiter, Amanda E. (2017). Antigen localization influences the magnitude and kinetics of endogenous adaptive immune response to recombinant Salmonella vaccines. Infection and Immunity, 85 (12) e00593-17, e00593-17. doi: 10.1128/iai.00593-17

MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis

Isom, Georgia L., Davies, Nathaniel J., Chong, Zhi-Soon, Bryant, Jack A., Jamshad, Mohammed, Sharif, Maria, Cunningham, Adam F., Knowles, Timothy J., Chng, Shu-Sin, Cole, Jeffrey A. and Henderson, Ian R. (2017). MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis. Scientific Reports, 7 (1) 8608. doi: 10.1038/s41598-017-09111-6

Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1

Marini, Arianna, Rossi, Omar, Aruta, Maria Grazia, Micoli, Francesca, Rondini, Simona, Guadagnuolo, Serafina, Delany, Isabel, Henderson, Ian R., Cunningham, Adam F., Saul, Allan, MacLennan, Calman A. and Koeberling, Oliver (2017). Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1. PLoS One, 12 (7) e0181508, e0181508. doi: 10.1371/journal.pone.0181508

Architectures of lipid transport systems for the bacterial outer membrane

Ekiert, Damian C., Bhabha, Gira, Isom, Georgia L., Greenan, Garrett, Ovchinnikov, Sergey, Henderson, Ian R., Cox, Jeffery S. and Vale, Ronald D. (2017). Architectures of lipid transport systems for the bacterial outer membrane. Cell, 169 (2), 273-285.e17. doi: 10.1016/j.cell.2017.03.019

The Use of Plasmapheresis in Patients with Bronchiectasis with Pseudomonas aeruginosa Infection and Inhibitory Antibodies

Wells, Timothy J., Davison, John, Sheehan, Emma, Kanagasundaram, Suren, Spickett, Gavin, MacLennan, Calman A., Stockley, Robert A., Cunningham, Adam F., Henderson, Ian R. and De Soyza, Anthony (2017). The Use of Plasmapheresis in Patients with Bronchiectasis with Pseudomonas aeruginosa Infection and Inhibitory Antibodies. American Journal of Respiratory and Critical Care Medicine, 195 (7), 955-958. doi: 10.1164/rccm.201603-0599LE

Sequencing a piece of history: complete genome sequence of the original Escherichia coli strain

Dunne, Karl A., Chaudhuri, Roy R., Rossiter, Amanda E., Beriotto, Irene, Browning, Douglas F., Squire, Derrick, Cunningham, Adam F., Cole, Jeffrey A., Loman, Nicholas and Henderson, Ian R. (2017). Sequencing a piece of history: complete genome sequence of the original Escherichia coli strain. Microbial Genomics, 3 (3) 000106. doi: 10.1099/mgen.0.000106

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3

Watson, Callum N., Kerrigan, Steven W., Cox, Dermot, Henderson, Ian R., Watson, Steve P. and Arman, Mònica (2016). Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3. Platelets, 27 (6), 535-540. doi: 10.3109/09537104.2016.1148129

A secretome view of colonisation factors in Shiga toxin-encoding Escherichia coli (STEC): from enterohaemorrhagic E. coli (EHEC) to related enteropathotypes

Monteiro, Ricardo, Ageorges, Valentin, Rojas-Lopez, Maricarmen, Schmidt, Herbert, Weiss, Agnes, Bertin, Yolande, Forano, Evelyne, Jubelin, Grégory, Henderson, Ian R., Livrelli, Valérie, Gobert, Alain P., Rosini, Roberto, Soriani, Marco and Desvaux, Mickaël (2016). A secretome view of colonisation factors in Shiga toxin-encoding Escherichia coli (STEC): from enterohaemorrhagic E. coli (EHEC) to related enteropathotypes. FEMS Microbiology Letters, 363 (16) fnw179, fnw179. doi: 10.1093/femsle/fnw179

Molecular characterisation of the Vacuolating Autotransporter Toxin in Uropathogenic Escherichia coli

Nichols, Katie B., Totsika, Makrina, Moriel, Danilo G., Lo, Alvin W., Yang, Ji, Wurpel, Daniel J., Rossiter, Amanda E., Strugnell, Richard A., Henderson, Ian R., Ulett, Glen C., Beatson, Scott A. and Schembri, Mark A. (2016). Molecular characterisation of the Vacuolating Autotransporter Toxin in Uropathogenic Escherichia coli. Journal of Bacteriology, 198 (10), 1487-1498. doi: 10.1128/JB.00791-15

Alternatives to antibiotics-a pipeline portfolio review

Czaplewski, Lloyd, Bax, Richard, Clokie, Martha, Dawson, Mike, Fairhead, Heather, Fischetti, Vincent A., Foster, Simon, Gilmore, Brendan F., Hancock, Robert E. W., Harper, David, Henderson, Ian R., Hilpert, Kai, Jones, Brian V., Kadioglu, Aras, Knowles, David, Ólafsdóttir, Sigrídur, Payne, David, Projan, Steve, Shaunak, Sunil, Silverman, Jared, Thomas, Christopher M., Trust, Trevor J., Warn, Peter and Rex, John H. (2016). Alternatives to antibiotics-a pipeline portfolio review. The Lancet Infectious Diseases, 16 (2), 239-251. doi: 10.1016/S1473-3099(15)00466-1

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

Hitchcock, Jessica R., Cook, Charlotte N., Bobat, Saeeda, Ross, Ewan A., Flores-Langarica, Adriana, Lowe, Kate L., Khan, Mahmood, Dominguez-Medina, C. Coral, Lax, Sian, Carvalho-Gaspar, Manuela, Hubscher, Stefan, Rainger, G. Ed, Cobbold, Mark, Buckley, Christopher D., Mitchell, Tim J., Mitchell, Andrea, Jones, Nick D., Van Rooijen, N., Kirchhofer, Daniel, Henderson, Ian R., Adams, David H., Watson, Steve P. and Cunningham, Adam F. (2015). Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. Journal of Clinical Investigation, 125 (12), 4429-4446. doi: 10.1172/jci79070

Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production: immunity to infection

Flores-Langarica, Adriana, Bobat, Saeeda, Marshall, Jennifer L., Yam-Puc, Juan Carlos, Cook, Charlotte N., Serre, Karine, Kingsley, Robert A., Flores-Romo, Leopoldo, Uematsu, Satoshi, Akira, Shizuo, Henderson, Ian R., Toellner, Kai M. and Cunningham, Adam F. (2015). Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production: immunity to infection. European Journal of Immunology, 45 (8), 2299-2311. doi: 10.1002/eji.201545564

Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion

Browning, Douglas F., Bavro, Vassiliy N., Mason, Jessica L., Sevastsyanovich, Yanina R., Rossiter, Amanda E., Jeeves, Mark, Wells, Timothy J., Knowles, Timothy J., Cunningham, Adam F., Donald, James W., Palmer, Tracy, Overduin, Michael and Henderson, Ian R. (2015). Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion. Molecular Microbiology, 97 (4), 646-659. doi: 10.1111/mmi.13052

Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that co-operate in a shared-recruitment mechanism

Rossiter, Amanda E., Godfrey, Rita E., Connolly, Jack A., Busby, Stephen J. W., Henderson, Ian R. and Browning, Douglas F. (2015). Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that co-operate in a shared-recruitment mechanism. Biochemical Journal, 466 (2), 323-335. doi: 10.1042/BJ20141315

Natural and vaccine-mediated immunity to Salmonella typhimurium is impaired by the helminth Nippostrongylus brasiliensis

Bobat, Saeeda, Darby, Matthew, Mrdjen, Dunja, Cook, Charlotte, Logan, Erin, Auret, Jennifer, Jones, Elizabeth, Schnoeller, Corinna, Flores-Langarica, Adriana, Ross, Ewan A., Vira, Alykhan, López-Macías, Constantino, Henderson, Ian R., Alexander, James, Brombacher, Frank, Horsnell, William G. and Cunningham, Adam F. (2014). Natural and vaccine-mediated immunity to Salmonella typhimurium is impaired by the helminth Nippostrongylus brasiliensis. PLoS Neglected Tropical Diseases, 8 (12) e3341, e3341. doi: 10.1371/journal.pntd.0003341

B1b cells recognize protective antigens after natural infection and vaccination

Cunningham, Adam E., Flores-Langarica, Adriana, Bobat, Saeeda, Medina, Carmen C. Dominguez, Cook, Charlotte N. L., Ross, Ewan A., Lopez-Macias, Constantino and Henderson, Ian R. (2014). B1b cells recognize protective antigens after natural infection and vaccination. Frontiers in Immunology, 5 (OCT) 535. doi: 10.3389/fimmu.2014.00535

Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing

Wells, Timothy J., Whitters, Deborah, Sevastsyanovich, Yanina R., Heath, Jennifer N., Pravin, John, Goodall, Margaret, Browning, Douglas F., O'Shea, Matthew K., Cranston, Amy, De Soyza, Anthony, Cunningham, Adam F., MacLennan, Calman A., Henderson, Ian R. and Stockley, Robert A. (2014). Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing. Journal of Experimental Medicine, 211 (9), 1893-1904. doi: 10.1084/jem.20132444

A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes

Leyton, Denisse L., Johnson, Matthew D., Thapa, Rajiv, Huysmans, Gerard H. M., Dunstan, Rhys A., Celik, Nermin, Shen, Hsin-Hui, Loo, Dorothy, Belousoff, Matthew J., Purcell, Anthony W., Henderson, Ian R., Beddoe, Travis, Rossjohn, Jamie, Martin, Lisandra L., Strugnell, Richard A. and Lithgow, Trevor (2014). A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes. Nature Communications, 5 (1) 4239. doi: 10.1038/ncomms5239

Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function: cellular immune response

Ross, Ewan A., Flores-Langarica, Adriana, Bobat, Saeeda, Coughlan, Ruth E., Marshall, Jennifer L., Hitchcock, Jessica R., Cook, Charlotte N., Carvalho-Gaspar, Manuela M., Mitchell, Andrea M., Clarke, Mary, Garcia, Paloma, Cobbold, Mark, Mitchell, Tim J., Henderson, Ian R., Jones, Nick D., Anderson, Graham, Buckley, Christopher D. and Cunningham, Adam F. (2014). Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function: cellular immune response. European Journal of Immunology, 44 (8), 2318-2330. doi: 10.1002/eji.201344350

Differential timing of antibody-mediated phagocytosis and cell-free killing of invasive African Salmonella allows immune evasion

Siggins, Matthew K., O'Shaughnessy, Colette M., Pravin, John, Cunningham, Adam F., Henderson, Ian R., Drayson, Mark T. and MacLennan, Calman A. (2014). Differential timing of antibody-mediated phagocytosis and cell-free killing of invasive African Salmonella allows immune evasion. European Journal of Immunology, 44 (4), 1093-1098. doi: 10.1002/eji.201343529

Mutational and topological analysis of the Escherichia coli BamA protein

Browning, Douglas F., Matthews, Sophie A., Rossiter, Amanda E., Sevastsyanovich, Yanina R., Jeeves, Mark, Mason, Jessica L., Wells, Timothy J., Wardius, Catherine A., Knowles, Timothy J., Cunningham, Adam F., Bavro, Vassiliy N., Overduin, Michael and Henderson, Ian R. (2013). Mutational and topological analysis of the Escherichia coli BamA protein. PLoS ONE, 8 (12) e84512, e84512. doi: 10.1371/journal.pone.0084512

Genotypic and phenotypic characterisation of enteroaggregative Escherichia coli from children in Rio de Janeiro, Brazil

Franca, Fernanda L. S., Wells, Timothy J., Browning, Douglas F., Nogueira, Raquel Tayar, Sarges, Felipe Silva, Pereira, Ana Claudia, Cunningham, Adam F., Lucheze, Kely, Paula Rosa, Ana Claudia, Henderson, Ian R. and de Luna, Maria das Gracas (2013). Genotypic and phenotypic characterisation of enteroaggregative Escherichia coli from children in Rio de Janeiro, Brazil. PLoS ONE, 8 (7) e69971, e69971. doi: 10.1371/journal.pone.0069971

Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis

Browning, Douglas F., Wells, Timothy J., Franca, Fernanda L. S., Morris, Faye C., Sevastsyanovich, Yanina R., Bryant, Jack A., Johnson, Matthew D., Lund, Peter A., Cunningham, Adam F., Hobman, Jon L., May, Robin C., Webber, Mark A. and Henderson, Ian R. (2013). Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis. Molecular Microbiology, 87 (5), 939-950. doi: 10.1111/mmi.12144

Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node

Flores-Langarica, Adriana, Marshall, Jennifer L., Hitchcock, Jessica, Cook, Charlotte, Jobanputra, Jonathan, Bobat, Saeeda, Ross, Ewan A., Coughlan, Ruth E., Henderson, Ian R., Uematsu, Satoshi, Akira, Shizuo and Cunningham, Adam F. (2012). Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node. The Journal of Immunology, 189 (12), 5745-5754. doi: 10.4049/jimmunol.1202283

The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen

Marshall, Jennifer L. , Flores-Langarica, Adriana, Kingsley, Robert A. , Hitchcock, Jessica R., Ross, Ewan A., Lopez-Macias, Constantino, Lakey, Jeremy, Martin, Laura B., Toellner, Kai-Michael, MacLennan, Calman A., MacLennan, Ian C., Henderson, Ian R., Dougan, Gordon and Cunningham, Adam F. (2012). The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen. The Journal of Immunology, 189 (12), 5527-5532. doi: 10.4049/jimmunol.1103166

Thymic function is maintained during Salmonella -induced atrophy and recovery

Ross, Ewan A., Coughlan, Ruth E., Flores-Langarica, Adriana, Lax, Sian, Nicholson, Julia, Desanti, Guillaume E., Marshall, Jennifer L., Bobat, Saeeda, Hitchcock, Jessica, White, Andrea, Jenkinson, William E., Khan, Mahmood, Henderson, Ian R., Lavery, Gareth G., Buckley, Christopher D., Anderson, Graham and Cunningham, Adam F. (2012). Thymic function is maintained during Salmonella -induced atrophy and recovery. The Journal of Immunology, 189 (9), 4266-4274. doi: 10.4049/jimmunol.1200070

Pride in a century-long tradition of microbiology in Birmingham

Pallen, Mark and Henderson, Ian (2012). Pride in a century-long tradition of microbiology in Birmingham. Microbiology Today, 39 (3), 156-159.

A generalised module for the selective extracellular accumulation of recombinant proteins

Sevastsyanovich, Yanina R., Leyton, Denisse L., Wells, Timothy J., Wardius, Catherine A., Tveen-Jensen, Karina, Morris, Faye C., Knowles, Timothy J., Cunningham, Adam F., Cole, Jeffrey A. and Henderson, Ian R. (2012). A generalised module for the selective extracellular accumulation of recombinant proteins. Microbial Cell Factories, 11 (69) 69. doi: 10.1186/1475-2859-11-69

Discovery of an archetypal protein transport system in bacterial outer membranes

Selkrig, Joel, Mosbahi, Khedidja, Webb, Chaille T., Belousoff, Matthew J., Perry, Andrew J., Wells, Timothy J., Morris, Faye, Leyton, Denisse L., Totsika, Makrina, Phan, Minh-Duy, Celik, Nermin, Kelly, Michelle, Oates, Clare, Hartland, Elizabeth L., Robins-Browne, Roy M., Ramarathinam, Sri Harsha, Purcell, Anthony W., Schembri, Mark A., Strugnell, Richard A., Henderson, Ian R., Walker, Daniel and Lithgow, Trevor (2012). Discovery of an archetypal protein transport system in bacterial outer membranes. Nature Structural and Molecular Biology, 19 (5), 506-510. doi: 10.1038/nsmb.2261

The evolution of the Escherichia coli phylogeny

Chaudhuri, Roy R. and Henderson, Ian R. (2012). The evolution of the Escherichia coli phylogeny. Infection, Genetics and Evolution, 12 (2), 214-226. doi: 10.1016/j.meegid.2012.01.005

From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis

Leyton, Denisse L., Rossiter, Amanda E. and Henderson, Ian R. (2012). From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis. Nature Reviews Microbiology, 10 (3), 213-225. doi: 10.1038/nrmicro2733

Size and conformation limits to secretion of disulfide-bonded loops in autotransporter proteins

Leyton, Denisse L., Sevastsyanovich, Yanina R., Browning, Douglas F., Rossiter, Amanda E., Wells, Timothy J., Fitzpatrick, Rebecca E., Overduin, Michael, Cunningham, Adam F. and Henderson, Ian R. (2011). Size and conformation limits to secretion of disulfide-bonded loops in autotransporter proteins. Journal of Biological Chemistry, 286 (49), 42283-42291. doi: 10.1074/jbc.M111.306118

SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection

Raghunathan, Dhaarini, Wells, Timothy J., Morris, Faye C., Shaw, Robert K., Bobat, Saeeda, Peters, Sarah E., Paterson, Gavin K., Jensen, Karina Tveen, Leyton, Denisse L., Blair, Jessica M. A., Browning, Douglas F., Pravin, John, Flores-Langarica, Adriana, Hitchcock, Jessica R., Moraes, Claudia T. P., Piazza, Roxane M. F., Maskell, Duncan J., Webber, Mark A., May, Robin C., MacLennan, Calman A., Piddock, Laura J., Cunningham, Adam F. and Henderson, Ian R. (2011). SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection. Infection and Immunity, 79 (11), 4342-4352. doi: 10.1128/IAI.05592-11

A systems biology approach sheds new light on Escherichia coli acid resistance

Stincone, Anna, Daudi, Nazish, Rahman, Ayesha S., Antczak, Philipp, Henderson, Ian, Cole, Jeffrey, Johnson, Matthew D., Lund, Peter and Falciani, Francesco (2011). A systems biology approach sheds new light on Escherichia coli acid resistance. Nucleic Acids Research, 39 (17), 7512-7528. doi: 10.1093/nar/gkr338

T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella

Flores-Langarica, Adriana, Marshall, Jennifer L., Bobat, Saeeda, Mohr, Elodie, Hitchcock, Jessica, Ross, Ewan A., Coughlan, Ruth E., Khan, Mahmood, Van Rooijen, Nico, Henderson, Ian R., Maclennan, Ian C. M. and Cunningham, Adam F. (2011). T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella. European journal of immunology, 41 (9), 2654-65. doi: 10.1002/eji.201141440

Cd31 is required on cd4+ T cells to promote T cell survival during Salmonella infection

Ross, Ewan A., Coughlan, Ruth E., Flores-Langarica, Adriana, Bobat, Saeeda, Marshall, Jennifer L., Hussain, Khiyam, Charlesworth, James, Abhyankar, Nikita, Hitchcock, Jessica, Gil, Cristina, Loṕez-Maciás, Constantino, Henderson, Ian R., Khan, Mahmood, Watson, Steve P., MacLennan, Ian C. M., Buckley, Christopher D. and Cunningham, Adam F. (2011). Cd31 is required on cd4+ T cells to promote T cell survival during Salmonella infection. Journal of Immunology, 187 (4), 1553-1565. doi: 10.4049/jimmunol.1000502

The essential beta-barrel assembly machinery complex components BamD and BamA are required for autotransporter biogenesis

Rossiter, Amanda E., Leyton, Denisse L., Tveen-Jensen, Karina, Browning, Douglas F., Sevastsyanovich, Yanina, Knowles, Timothy J., Nichols, Katie B., Cunningham, Adam F., Overduin, Michael, Schembri, Mark A. and Henderson, Ian R. (2011). The essential beta-barrel assembly machinery complex components BamD and BamA are required for autotransporter biogenesis. Journal of Bacteriology, 193 (16), 4250-4253. doi: 10.1128/JB.00192-11

Transcription of the plasmid-encoded toxin gene from Enteroaggregative Escherichia coli is regulated by a novel co-activation mechanism involving CRP and Fis

Rossiter, Amanda E., Browning, Douglas F., Leyton, Denisse L., Johnson, Matthew D., Godfrey, Rita E., Wardius, Catherine A., Desvaux, Mickael, Cunningham, Adam F., Ruiz-Perez, Fernando, Nataro, James P., Busby, Stephen J. W. and Henderson, Ian R. (2011). Transcription of the plasmid-encoded toxin gene from Enteroaggregative Escherichia coli is regulated by a novel co-activation mechanism involving CRP and Fis. Molecular Microbiology, 81 (1), 179-191. doi: 10.1111/j.1365-2958.2011.07685.x

Complete Genome Sequence of the Crohn's Disease-Associated Adherent-Invasive Escherichia coliStrain HM605

Clarke, David J., Chaudhuri, Roy R., Martin, Helen M., Campbell, Barry J., Rhodes, Jonathan M., Constantinidou, Chrystala , Pallen, Mark J., Loman, Nicholas J., Cunningham, Adam F., Browning, Douglas F. and Henderson, Ian R. (2011). Complete Genome Sequence of the Crohn's Disease-Associated Adherent-Invasive Escherichia coliStrain HM605. Journal of Bacteriology, 193 (17), 4540-4540. doi: 10.1128/jb.05374-11

Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection

Bobat, Saeeda, Flores-Langarica, Adriana, Hitchcock, Jessica, Marshall, Jennifer L., Kingsley, Robert A., Goodall, Margaret, Gil-Cruz, Cristina, Serre, Karine, Leyton, Denisse L., Letran, Shirdi E., Gaspal, Fabrina, Chester, Rebecca, Chamberlain, Jayne L., Dougan, Gordon, López-Macías, Constantino, Henderson, Ian R., Alexander, James, Maclennan, Ian C. M. and Cunningham, Adam F. (2011). Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection. European Journal of Immunology, 41 (6), 1606-1618. doi: 10.1002/eji.201041089

Genome sequence of the emerging pathogen aeromonas caviae

Beatson, Scott A., de Luna, Maria das Graças, Bachmann, Nathan L., Alikhan, Nabil-Fareed, Hanks, Kirstin R., Sullivan, Mitchell J., Wee, Bryan A., Freitas-Almeida, Angela C., dos Santos, Paula A., de Melo, Janyne T. B., Squire, Derrick J. P., Cunningham, Adam F., Fitzgerald, J. Ross and Henderson, Ian R. (2011). Genome sequence of the emerging pathogen aeromonas caviae. Journal of Bacteriology, 193 (5), 1286-1287. doi: 10.1128/JB.01337-10

Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody

Siggins, Matthew K., Cunningham, Adam F., Marshall, Jennifer L., Chamberlain, Jayne L., Henderson, Ian R. and MacLennan, Calman A. (2011). Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody. The Journal of Immunology, 186 (4), 2365-71. doi: 10.4049/jimmunol.1000284

Structure and function of BamE within the outer membrane and the β-barrel assembly machine

Knowles, Timothy J., Browning, Douglas F., Jeeves, Mark, Maderbocus, Riyaz, Rajesh, Sandya, Sridhar, Pooja, Manoli, Eleni, Emery, Danielle, Sommer, Ulf, Spencer, Ashley, Leyton, Denisse L., Squire, Derrick, Chaudhuri, Roy R., Viant, Mark R., Cunningham, Adam F., Henderson, Ian R. and Overduin, Michael (2011). Structure and function of BamE within the outer membrane and the β-barrel assembly machine. EMBO Reports, 12 (2), 123-128. doi: 10.1038/embor.2010.202

The bacterial intimins and invasins: A large and novel family of secreted proteins

Tsai, Jennifer C., Yen, Ming-Ren, Castillo, Rostislav, Leyton, Denisse L., Henderson, Ian R. and Saier, Milton H. (2010). The bacterial intimins and invasins: A large and novel family of secreted proteins. PLoS ONE, 5 (12) e14403, e14403. doi: 10.1371/journal.pone.0014403

A commensal gone bad: Complete genome sequence of the prototypical enterotoxigenic escherichia coli strain H10407

Crossman, L. C., Chaudhuri, R. R., Beatson, S. A., Wells, T. J., Desvaux, M., Cunningham, A. F., Petty, N. K., Mahon, V., Brinkley, C., Hobman, J. L., Savarino, S. J., Turner, S. M., Pallen, M. J., Penn, C. W., Parkhill, J., Turner, A. K., Johnson, T. J., Thomson, N. R., Smith, S. G. J. and Henderson, I. R. (2010). A commensal gone bad: Complete genome sequence of the prototypical enterotoxigenic escherichia coli strain H10407. Journal of Bacteriology, 192 (21), 5822-5831. doi: 10.1128/JB.00710-10

The unusual extended signal peptide region is not required for secretion and function of an Escherichia coli autotransporter

Leyton, Denisse L., De Luna, Maria das Graças, Sevastsyanovich, Yanina R., Tveen Jensen, Karina, Browning, Douglas F., Scott-Tucker, Anthony and Henderson, Ian R. (2010). The unusual extended signal peptide region is not required for secretion and function of an Escherichia coli autotransporter. FEMS Microbiology Letters, 311 (2), 133-139. doi: 10.1111/j.1574-6968.2010.02081.x

C-terminal amino acid residues of the trimeric autotransporter adhesin YadA of Yersinia enterocolitica are decisive for its recognition and assembly by BamA: YadA is recognized and assembled by the BAM complex

Lehr, U., Schütz, M., Oberhettinger, P., Ruiz-Perez, F., Donald, J. W., Palmer, T., Linke, D., Henderson, I. R. and Autenrieth, I. B. (2010). C-terminal amino acid residues of the trimeric autotransporter adhesin YadA of Yersinia enterocolitica are decisive for its recognition and assembly by BamA: YadA is recognized and assembled by the BAM complex. Molecular Microbiology, 78 (4), 932-946. doi: 10.1111/j.1365-2958.2010.07377.x

Interaction of FkpA, a peptidyl-prolyl cis/trans isomerase with EspP autotransporter protein

Ruiz-Perez, Fernando, Henderson, Ian R. and Nataro, James P. (2010). Interaction of FkpA, a peptidyl-prolyl cis/trans isomerase with EspP autotransporter protein. Gut Microbes, 1 (5), 339-344. doi: 10.4161/gmic.1.5.13436

Secondary structure and 1H, 13C and 15N resonance assignments of BamE, a component of the outer membrane protein assembly machinery in Escherichia coli

Knowles, Timothy J., Sridhar, Pooja, Rajesh, Sandya, Manoli, Eleni, Overduin, Michael and Henderson, Ian R. (2010). Secondary structure and 1H, 13C and 15N resonance assignments of BamE, a component of the outer membrane protein assembly machinery in Escherichia coli. Biomolecular NMR Assignments, 4 (2), 179-181. doi: 10.1007/s12104-010-9236-7

Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-Infected african adults

MacLennan, Calman A., Gilchrist, James J., Gordon, Melita A., Cunningham, Adam F., Cobbold, Mark, Goodall, Margaret, Kingsley, Robert A., Van Oosterhout, Joep J. G., Msefula, Chisomo L., Mandala, Wilson L., Leyton, Denisse L., Marshall, Jennifer L., Gondwe, Esther N., Bobat, Saeeda, López-Macias, Constantino, Doffinger, Rainer, Henderson, Ian R., Zijlstra, Eduard E., Dougan, Gordon, Drayson, Mark T., MacLennan, Ian C. M. and Molyneux, Malcolm E. (2010). Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-Infected african adults. Science, 328 (5977), 508-512. doi: 10.1126/science.1180346

Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042

Chaudhuri, Roy R., Sebaihia, Mohammed, Hobman, Jon L., Webber, Mark A., Leyton, Denisse L., Goldberg, Martin D., Cunningham, Adam F., Scott-Tucker, Anthony, Ferguson, Paul R., Thomas, Christopher M., Frankel, Gad, Tang, Christoph M., Dudley, Edward G., Roberts, Ian S., Rasko, David A., Pallen, Mark J., Parkhill, Julian, Nataro, James P., Thomson, Nicholas R. and Henderson, Ian R. (2010). Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. PLoS ONE, 5 (1) e8801, e8801. doi: 10.1371/journal.pone.0008801

Roles of periplasmic chaperone proteins in the biogenesis of serine protease autotransporters of Enterobacteriaceae

Ruiz-Perez, Fernando, Henderson, Ian R., Leyton, Denisse L., Rossiter, Amanda E., Zhang, Yinghua and Nataro, James P. (2009). Roles of periplasmic chaperone proteins in the biogenesis of serine protease autotransporters of Enterobacteriaceae. Journal of Bacteriology, 191 (21), 6571-6583. doi: 10.1128/JB.00754-09

The Orientation of a Tandem POTRA Domain Pair, of the Beta-Barrel Assembly Protein BamA, Determined by PELDOR Spectroscopy

Ward, R., Zoltner, M., Beer, L., El Mkami, H., Henderson, I. R., Palmer, T. and Norman, D. G. (2009). The Orientation of a Tandem POTRA Domain Pair, of the Beta-Barrel Assembly Protein BamA, Determined by PELDOR Spectroscopy. Structure, 17 (9), 1187-1194. doi: 10.1016/j.str.2009.07.011

Interaction of enteroaggregative Escherichia coli with salad leaves

Berger, Cedric N., Shaw, Robert K., Ruiz-Perez, Fernando, Nataro, James P., Henderson, Ian R., Pallen, Mark J. and Frankel, Gad (2009). Interaction of enteroaggregative Escherichia coli with salad leaves. Environmental Microbiology Reports, 1 (4), 234-239. doi: 10.1111/j.1758-2229.2009.00037.x

Outer membrane translocation: numerical protein secretion nomenclature in question in mycobacteria

Desvaux, Mickaël, Hébraud, Michel, Talon, Régine and Henderson, Ian R. (2009). Outer membrane translocation: numerical protein secretion nomenclature in question in mycobacteria. Trends in Microbiology, 17 (8), 338-340. doi: 10.1016/j.tim.2009.05.008

Secondary structure and 1H, 13C and 15N backbone resonance assignments of BamC, a component of the outer membrane protein assembly machinery in Escherichia coli

Knowles, Timothy J., McClelland, Darren M., Rajesh, Sandya, Henderson, Ian R. and Overduin, Michael (2009). Secondary structure and 1H, 13C and 15N backbone resonance assignments of BamC, a component of the outer membrane protein assembly machinery in Escherichia coli. Biomolecular NMR Assignments, 3 (2), 203-206. doi: 10.1007/s12104-009-9175-3

The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response

Gil-Cruz, Cristina, Bobat, Saeeda, Marshall, Jennifer L., Kingsley, Robert A., Ross, Ewan A., Henderson, Ian R., Leyton, Denisse L., Coughlan, Ruth E., Khan, Mahmood, Jensen, Karina T., Buckley, Christopher D., Dougan, Gordon, MacLennan, Ian C. M., López-Macías, Constantino and Cunningham, Adam F. (2009). The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response. Proceedings of the National Academy of Sciences of the United States of America, 106 (24), 9803-9808. doi: 10.1073/pnas.0812431106

The Pic Protease of Enteroaggregative Escherichia coli Promotes Intestinal Colonization and Growth in the Presence of Mucin

Harrington, S. M., Sheikh, J., Henderson, I. R., Ruiz-Perez, F., Cohen, P. S. and Nataro, J. P. (2009). The Pic Protease of Enteroaggregative Escherichia coli Promotes Intestinal Colonization and Growth in the Presence of Mucin. Infection and Immunity, 77 (6), 2465-2473. doi: 10.1128/iai.01494-08

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue

Desvaux, Mickaël, Hébraud, Michel, Talon, Régine and Henderson, Ian R. (2009). Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue. Trends in Microbiology, 17 (4), 139-145. doi: 10.1016/j.tim.2009.01.004

Membrane protein architects: the role of the BAM complex in outer membrane protein assembly

Knowles, Timothy J., Scott-Tucker, Anthony, Overduin, Michael and Henderson, Ian R. (2009). Membrane protein architects: the role of the BAM complex in outer membrane protein assembly. Nature Reviews Microbiology, 7 (3), 206-214. doi: 10.1038/nrmicro2069

Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69

Iguchi, Atsushi, Thomson, Nicholas R., Ogura, Yoshitoshi, Saunders, David, Ooka, Tadasuke, Henderson, Ian R., Harris, David, Asadulghani, M., Kurokawa, Ken, Dean, Paul, Kenny, Brendan, Quail, Michael A., Thurston, Scott, Dougan, Gordon, Hayashi, Tetsuya, Parkhill, Julian and Frankel, Gad (2009). Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69. Journal of Bacteriology, 91 (1), 347-354. doi: 10.1128/JB.01238-08

The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates

Rasko, David A., Rosovitz, M. J., Myers, Garry S. A., Mongodin, Emmanuel F., Fricke, W. Florian, Gajer, Pawel, Crabtree, Jonathan, Sebaihia, Mohammed, Thomson, Nicholas R., Chaudhuri, Roy, Henderson, Ian R., Sperandio, Vanessa and Ravel, Jacques (2008). The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates. Journal of Bacteriology, 190 (20), 6881-6893. doi: 10.1128/JB.00619-08

Common themes and variations in serine protease autotransporters

Yen, Yihfen T., Kostakioti, Maria, Henderson, Ian R. and Stathopoulos, Christos (2008). Common themes and variations in serine protease autotransporters. Trends in Microbiology, 16 (8), 370-9. doi: 10.1016/j.tim.2008.05.003

The Escherichia coli biofilm-promoting protein Antigen 43 does not contribute to intestinal colonization

de Luna, Maria das Gracas, Scott-Tucker, Anthony, Desvaux, Mickael, Ferguson, Paul, Morin, Nicholas P., Dudley, Edward G., Turner, Sue, Nataro, James P., Owen, Peter and Henderson, Ian R. (2008). The Escherichia coli biofilm-promoting protein Antigen 43 does not contribute to intestinal colonization. FEMS Microbiology Letters, 284 (2), 237-246. doi: 10.1111/j.1574-6968.2008.01207.x

Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes

Knowles, Timothy J., Jeeves, Mark, Bobat, Saeeda, Dancea, Felician, McClelland, Darren, Palmer, Tracy, Overduin, Michael and Henderson, Ian R. (2008). Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes. Molecular Microbiology, 68 (5), 1216-1227. doi: 10.1111/j.1365-2958.2008.06225.x

Regulation and function of Ag43 (Flu)

van der Woude, Marjan W. and Henderson, Ian R. (2008). Regulation and function of Ag43 (Flu). Annual Review of Microbiology, 62 (1), 153-169. doi: 10.1146/annurev.micro.62.081307.162938

Secondary structure and 1H, 13C and 15N resonance assignments of the Escherichia coli YaeT POTRA domain

Knowles, Timothy J., Bobat, Saeeda, Jeeves, Mark, Henderson, Ian R. and Overduin, Michael (2007). Secondary structure and 1H, 13C and 15N resonance assignments of the Escherichia coli YaeT POTRA domain. Biomolecular NMR Assignments, 1 (1), 113-115. doi: 10.1007/s12104-007-9032-1

Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection

Cunningham, Adam F., Gaspal, Fabrina, Serre, Karine, Mohr, Elodie, Henderson, Ian R., Scott-Tucker, Anthony, Kenny, Sinead M., Khan, Mahmood, Toellner, Kai-Michael, Lane, Peter J. L. and MacLennan, Ian C. M. (2007). Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection. Journal of Immunology, 178 (10), 6200-6207. doi: 10.4049/jimmunol.178.10.6200

A conserved extended signal peptide region directs posttranslational protein translocation via a novel mechanism

Desvaux, Mickaël, Scott-Tucker, Anthony, Turner, Sue M., Cooper, Lisa M., Huber, Damon, Nataro, James P. and Henderson, Ian R. (2007). A conserved extended signal peptide region directs posttranslational protein translocation via a novel mechanism. Microbiology, 153 (1), 59-70. doi: 10.1099/mic.0.29091-0

Phylogenetic comparisons reveal multiple acquisitions of the toxin genes by enterotoxigenic Escherichia coli strains of different evolutionary lineages

Turner, Sue M., Chaudhuri, Roy R., Jiang, Zhi-Dong, DuPont, Herbert, Gyles, Carlton, Penn, Charles W., Pallen, Mark J. and Henderson, Ian R. (2006). Phylogenetic comparisons reveal multiple acquisitions of the toxin genes by enterotoxigenic Escherichia coli strains of different evolutionary lineages. Journal of Clinical Microbiology, 44 (12), 4528-4536. doi: 10.1128/JCM.01474-06

The unusual extended signal peptide region of the type V secretion system is phylogenetically restricted

Desvaux, Mickaël, Cooper, Lisa M., Filenko, Nina A., Scott-Tucker, Anthony, Turner, Sue M., Cole, Jeffrey A. and Henderson, Ian R. (2006). The unusual extended signal peptide region of the type V secretion system is phylogenetically restricted. FEMS Microbiology Letters, 264 (1), 22-30. doi: 10.1111/j.1574-6968.2006.00425.x

Weapons of mass destruction: virulence factors of the global killer enterotoxigenic Escherichia coli

Turner, Susan M., Scott-Tucker, Anthony, Cooper, Lisa M. and Henderson, Ian R. (2006). Weapons of mass destruction: virulence factors of the global killer enterotoxigenic Escherichia coli. FEMS Microbiology Letters, 263 (1), 10-20. doi: 10.1111/j.1574-6968.2006.00401.x

Type III secretion: what's in a name?

Desvaux, Mickaël, Hébraud, Michel, Henderson, Ian R. and Pallen, Mark J. (2006). Type III secretion: what's in a name?. Trends in Microbiology, 14 (4), 157-160. doi: 10.1016/j.tim.2006.02.009

Autotransporter proteins

Henderson, Ian R. and Nataro, James P. (2005). Autotransporter proteins. EcoSal Plus, 1 (2) ecosalplus.8.7.3. doi: 10.1128/ecosalplus.8.7.3

Genomic analysis of the protein secretion systems in Clostridium acetobutylicum ATCC 824

Desvaux, Mickaël, Khan, Arshad, Scott-Tucker, Anthony, Chaudhuri, Roy R., Pallen, Mark J. and Henderson, Ian R. (2005). Genomic analysis of the protein secretion systems in Clostridium acetobutylicum ATCC 824. Biochimica et Biophysica Acta - Molecular Cell Research, 1745 (2), 223-253. doi: 10.1016/j.bbamcr.2005.04.006

Distribution of the serine protease autotransporters of the Enterobacteriaceae among extraintestinal clinical isolates of Escherichia coli

Parham, N.J., Pollard, S.J., Desvaux, M., Scott-Tucker, A., Liu, C.J., Fivian, A. and Henderson, I.R. (2005). Distribution of the serine protease autotransporters of the Enterobacteriaceae among extraintestinal clinical isolates of Escherichia coli. Journal of Clinical Microbiology, 43 (8), 4076-4082. doi: 10.1128/JCM.43.8.4076-4082.2005

Protein secretion systems in Fusobacterium nucleatum: Genomic identification of Type 4 piliation and complete Type V pathways brings new insight into mechanisms of pathogenesis

Desvaux, Mickaël, Khan, Arshad, Beatson, Scott A., Scott-Tucker, Anthony and Henderson, Ian R. (2005). Protein secretion systems in Fusobacterium nucleatum: Genomic identification of Type 4 piliation and complete Type V pathways brings new insight into mechanisms of pathogenesis. Biochimica Et Biophysica Acta-biomembranes, 1713 (2), 92-112. doi: 10.1016/j.bbamem.2005.05.002

Prevalence of pathogenicity island IICFT073 genes among extraintestinal clinical isolates of Escherichia coli

Parham, Nick J., Pollard, Samantha J., Chaudhuri, Roy R., Beatson, Scott A., Desvaux, Mickaël, Russell, Michael A., Ruiz, Joaquim, Fivian, Amanda, Vila, Jordi and Henderson, Ian R. (2005). Prevalence of pathogenicity island IICFT073 genes among extraintestinal clinical isolates of Escherichia coli. Journal of Clinical Microbiology, 43 (5), 2425-2434. doi: 10.1128/JCM.43.5.2425-2434.2005

Type V protein secretion pathway: the autotransporter story

Henderson, I.R., Navarro-Garcia, F., Desvaux, M., Fernandez, R.C. and Ala'Aldeen, D. (2004). Type V protein secretion pathway: the autotransporter story. Microbiology and Molecular Biology Reviews, 68 (4), 692-744. doi: 10.1128/MMBR.68.4.692-744.2004

The general secretory pathway: A general misnomer?

Desvaux, Mickaël, Parham, Nicholas J., Scott-Tucker, Anthony and Henderson, Ian R. (2004). The general secretory pathway: A general misnomer?. Trends in Microbiology, 12 (7), 306-309. doi: 10.1016/j.tim.2004.05.002

Type V protein secretion: simplicity gone awry?

Desvaux, M., Parham, N.J. and Henderson, I.R. (2004). Type V protein secretion: simplicity gone awry?. Current Issues in Molecular Biology, 6 (2), 111-124.

The autotransporter secretion system

Desvaux, M., Parham, N.J. and Henderson, I.R. (2004). The autotransporter secretion system. Research in Microbiology, 155 (2), 53-60. doi: 10.1016/j.resmic.2003.10.002

PicU, a second serine protease autotransporter of uropathogenic Escherichia coli

Parham, Nick J., Srinivasan, Usha, Desvaux, Mickaël, Foxman, Betsy, Marrs, Carl F. and Henderson, Ian R. (2004). PicU, a second serine protease autotransporter of uropathogenic Escherichia coli. FEMS Microbiology Letters, 230 (1), 73-83. doi: 10.1016/S0378-1097(03)00862-0

Genomic analysis of secretion systems

Pallen, Mark J., Chaudhuri, Roy R. and Henderson, Ian R. (2003). Genomic analysis of secretion systems. Current Opinion in Microbiology, 6 (5), 519-527. doi: 10.1016/j.mib.2003.09.005

Secretory system in Gram negative bacterium type V Le système de sécrétion de type V chez les bactéries Gram-négatives

Desvaux, Mickaël, Parham, Nicholas J. and Henderson, Ian R. (2003). Secretory system in Gram negative bacterium type V Le système de sécrétion de type V chez les bactéries Gram-négatives. Biofutur (237), 34-37.

A novel dispersin protein in enteroaggregative Escherichia coli

Sheikh, Jalaluddin, Czeczulin, John, Harrington, Susan, Hicks, Susan, Henderson, Ian R., Le Bouguenec, Chantal, Gounon, Pierre, Phillips, Alan and Nataro, James P. (2002). A novel dispersin protein in enteroaggregative Escherichia coli. Journal of Clinical Investigation, 110 (9), 1329-1337. doi: 10.1172/JCI16172

Polymorphic proteins of Chlamydia spp. - autotransporters beyond the Proteobacteria

Henderson, IR and Lam, AC (2001). Polymorphic proteins of Chlamydia spp. - autotransporters beyond the Proteobacteria. Trends in Microbiology, 9 (12), 573-578. doi: 10.1016/S0966-842X(01)02234-X

Virulence functions of autotransporter proteins

Henderson, Ian R. and Nataro, James P. (2001). Virulence functions of autotransporter proteins. Infection and Immunity, 69 (3), 1231-1243. doi: 10.1128/IAI.69.3.1231-1243.2001

Autotransporter proteins, evolution and redefining protein secretion

Henderson, Ian R., Cappello, Renato and Nataro, James P. (2000). Autotransporter proteins, evolution and redefining protein secretion. Trends in Microbiology, 8 (12), 529-532. doi: 10.1016/S0966-842X(00)01853-9

Autotransporter proteins, evolution and redefining protein secretion: response

Henderson, Ian R., Cappello, Renat and Nataro, James P. (2000). Autotransporter proteins, evolution and redefining protein secretion: response. Trends in Microbiology, 8 (12), 534-535. doi: 10.1016/S0966-842X(00)01884-9

Enteroaggregative Escherichia coli virulence factors in traveler's diarrhea strains

Vila, J., Vargas, M., Henderson, I.R., Gascon, J. and Nataro, J.P. (2000). Enteroaggregative Escherichia coli virulence factors in traveler's diarrhea strains. Journal of Infectious Diseases, 182 (6), 1780-1783. doi: 10.1086/317617

Identification of Sat, an autotransporter toxin produced by uropathogenic Escherichia coli

Guyer, Debra M., Henderson, Ian R., Nataro, James P. and Mobley, Harry L. T. (2000). Identification of Sat, an autotransporter toxin produced by uropathogenic Escherichia coli. Molecular Microbiology, 38 (1), 53-66. doi: 10.1046/j.1365-2958.2000.02110.x

Renaming protein secretion in the Gram-negative bacteria

Henderson, Ian R., Nataro, James P., Kaper, James B., Meyer, Thomas F., Farrand, Stephen K., Burns, Drusilla L., Finlay, B. Brett and St Gene, Joseph W. (2000). Renaming protein secretion in the Gram-negative bacteria. Trends in Microbiology, 8 (8), 352-352. doi: 10.1016/S0966-842X(00)01814-X

The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation

Al-Hasani, Keith, Henderson, Ian R., Sakellaris, Harry, Rajakumar, Kumar, Grant, Travis, Nataro, James P., Robins-Browne, Roy and Adler, Ben (2000). The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation. Infection and Immunity, 68 (5), 2457-2463. doi: 10.1128/IAI.68.5.2457-2463.2000

Human immunodeficiency virus type 1 infection is associated with significant mucosal inflammation characterized by increased expression of CCR5, CXCR4, and β-chemokines

Vila, Jordi, Vargas, Martha, Henderson, Ian R., Gascon, Joaquim and Nataro, James (2000). Human immunodeficiency virus type 1 infection is associated with significant mucosal inflammation characterized by increased expression of CCR5, CXCR4, and β-chemokines. Journal of Infectious Diseases, 182 (6), 1625-1635. doi: 10.1086/317625

Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli

Henderson, I. R., Czeczulin, J., Eslava, C., Noriega, F. and Nataro, J. P. (1999). Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli. Infection and Immunity, 67 (11), 5587-5596.

Involvement of the enteroaggregative Escherichia coli plasmid-encoded toxin in causing human intestinal damage

Henderson, I. R., Hicks, S., Navarro-Garcia, F., Elias, W. P., Philips, A. D. and Nataro, J. P. (1999). Involvement of the enteroaggregative Escherichia coli plasmid-encoded toxin in causing human intestinal damage. Infection and Immunity, 67 (10), 5338-5344.

Molecular switches - the ON and OFF of bacterial phase variation

Henderson, I.R., Owen, P. and Nataro, J.P. (1999). Molecular switches - the ON and OFF of bacterial phase variation. Molecular Microbiology, 33 (5), 919-932. doi: 10.1046/j.1365-2958.1999.01555.x

A conserved motif in the hexosyltransferases

Henderson, Ian R. and Nataro, James P. (1999). A conserved motif in the hexosyltransferases. Molecular Microbiology, 33 (1), 222-222. doi: 10.1046/j.1365-2958.1999.01447.x

Phylogenetic analysis of enteroaggregative and diffusely adherent Escherichia coli

Czeczulin, J., Whittam, T. S., Henderson, I. R., Navarro-Garcia, F. and Nataro, J. P. (1999). Phylogenetic analysis of enteroaggregative and diffusely adherent Escherichia coli. Infection and Immunity, 67 (6), 2692-2699.

The major phase-variable outer membrane protein of Escherichia coli structurally resembles the immunoglobulin A1 protease class of exported protein and is regulated by a novel mechanism involving Dam and OxyR

Henderson, I. R. and Owen, P. (1999). The major phase-variable outer membrane protein of Escherichia coli structurally resembles the immunoglobulin A1 protease class of exported protein and is regulated by a novel mechanism involving Dam and OxyR. Journal of Bacteriology, 181 (7), 2132-2141.

Organization of biogenesis genes for aggregative adherence fimbria II defines a virulence gene cluster in enteroaggregative Escherichia coli

Elias, WP, Czeczulin,, Henderson, IR, Trabulsi, LR and Nataro, JP (1999). Organization of biogenesis genes for aggregative adherence fimbria II defines a virulence gene cluster in enteroaggregative Escherichia coli. Journal of Bacteriology, 181 (6), 1779-1785.

The great escape: structure and function of the autotransporter proteins

Henderson, Ian R., Navarro-Garcia, Fernando and Nataro, James P. (1998). The great escape: structure and function of the autotransporter proteins. Trends in Microbiology, 6 (9), 370-378. doi: 10.1016/S0966-842X(98)01318-3

Pet, an autotransporter enterotoxin from enteroaggregative Escherichia coli

Eslava, C., Navarro-Garcia, F., Czeczulin, J.R., Henderson, I.R., Cravioto, A. and Nataro, J.P. (1998). Pet, an autotransporter enterotoxin from enteroaggregative Escherichia coli. Infection and Immunity, 66 (7), 3155-3163.

A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli

Henderson, Ian R., Meehan, Mary and Owen, Peter (1997). A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli. Advances in Experimental Medicine and Biology, 412, 349-355.

The autoregulatory protein Mor and OxyR are identical

Henderson, Ian and Owen, Peter (1997). The autoregulatory protein Mor and OxyR are identical. Microbiology, 143 (5), 1482-1482. doi: 10.1099/00221287-143-5-1482

Antigen 43, a phase-variable bipartite outer membrane protein, determines colony morphology and autoaggregation in Escherichia coli K-12

Henderson, Ian R., Meehan, Mary and Owen, Peter (1997). Antigen 43, a phase-variable bipartite outer membrane protein, determines colony morphology and autoaggregation in Escherichia coli K-12. FEMS Microbiology Letters, 149 (1), 115-120. doi: 10.1111/j.1574-6968.1997.tb10317.x

Phase-variable outer membrane proteins inEscherichia coli

Owen, Peter, Meehan, Mary, de Loughry-Doherty, Helen and Henderson, Ian (1996). Phase-variable outer membrane proteins inEscherichia coli. FEMS Immunology & Medical Microbiology, 16 (2), 63-76. doi: 10.1111/j.1574-695x.1996.tb00124.x

A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli

Henderson, Ian R. , Meehan, Mary and Owen, Peter (1997). A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli. 1st International Rushmore Conference on Mechanisms in the Pathogenesis of Enteric Diseases, Rapid City, SD, United States, 28-30 September 1995. New York, United States: Springer . doi: 10.1007/978-1-4899-1828-4_56

Phase-variable outer membrane proteins in Escherichia coli

Owen, Peter, Meehan, Mary, De Loughry-Doherty, Helen and Henderson, Ian (1996). Phase-variable outer membrane proteins in Escherichia coli. doi: 10.1016/S0928-8244(96)00069-7