The University of Queensland

Inflammasomes in CNS diseases

Albornoz, Eduardo A., Woodruff, Trent M. and Gordon, Richard (2018). Inflammasomes in CNS diseases. In Mario D. Cordero and Elisabet Alcocer-Gómez (Ed.), Inflammasomes: clinical and therapeutic implications (pp. 41-60) Cham, Switzerland: Springer International. doi:10.1007/978-3-319-89390-7_3

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018) Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 465: . doi:10.1126/scitranslmed.aah4066

Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour

Giacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018) Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour. The Journal of Infectious Diseases, 218 9: 1511-1516. doi:10.1093/infdis/jiy092

The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microglia

Deora, Vandana, Albornoz, Eduardo A., Zhu, Kevin, Woodruff, Trent M. and Gordon, Richard (2017) The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microglia. Journal of Neuroimmune Pharmacology, 12 4: 1-7. doi:10.1007/s11481-017-9754-5

Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring (vol 23, pg 1627, 2013)

Albornoz, E. A., Carreno, L. J., Cortes, C. M., Gonzalez, P. A., Cisternas, P. A., Cautivo, K. M., Catalan, T. P., Opazo, M. C., Eugenin, E. A., Berman, J. W., Bueno, S. M., Kalergis, A. M. and Riedel, C. A. (2015) Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring (vol 23, pg 1627, 2013). Thyroid, 25 9: 1068-1068. doi:10.1089/thy.2012.0401.cxn

Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species

Arriagada, Alejandro A., Albornoz, Eduardo, Cecilia Opazo, Ma., Becerra, Alvaro, Vidal, Gonzalo, Fardella, Carlos, Michea, Luis, Carrasco, Nancy, Simon, Felipe, Elorza, Alvaro A., Bueno, Susan M., Kalergis, Alexis M. and Riedel, Claudia A. (2015) Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species. Endocrinology, 156 4: 1540-1551. doi:10.1210/en.2014-1371

Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring

Albornoz, Eduardo A., Carreno, Leandro J., Cortes, Claudia M., Gonzalez, Pablo A., Cisternas, Pablo A., Cautivo, Kelly M., Catalan, Tamara P., Cecilia Opazo, M., Eugenin, Eliseo A., Berman, Joan W., Bueno, Susan M., Kalergis, Alexis M. and Riedel, Claudia A. (2013) Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring. Thyroid, 23 12: 1627-1637. doi:10.1089/thy.2012.0401

C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation

Gordon, Richard, Albornoz, Eduardo, Kanthasamy, Anumantha and Woodruff, Trent (2018). C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation. In: 27th International Complement Workshop (ICW), Santa Fe, NM, United States, (229-229). Sep 16-20, 2018. doi:10.1016/j.molimm.2018.06.247

GUT MICROBIOME CHANGES INDUCED BY EXPERIMENTAL TRICHURIS MURIS INFECTION ARE ASSOCIATED WITH DECREASED COGNITIVE FUNCTION IN MICE

Magalhaes, Ricardo J. Soares, Giacomin, Paul, Sarnyay, Zoltan, Kraeuter, Ann, Urich, Tim, Bengtsson, Mia, Jin, Shuting, Albornoz, Eduardo A., Gordon, Richard and Woodruff, Trent (2017). GUT MICROBIOME CHANGES INDUCED BY EXPERIMENTAL TRICHURIS MURIS INFECTION ARE ASSOCIATED WITH DECREASED COGNITIVE FUNCTION IN MICE. In: 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Atlanta Ga, (585-585). Nov 13-16, 2016.

Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1

Gordon, Richard, Albornoz, Eduardo A., Kumar, Vinod, Zhou, Kiane, Garin-Michaud, Ashoka, Mantavani, Susanna, Kanthasamy, Anumantha G. and Woodruff, Trent M. (2016). Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1. In: The XXVI International Complement Workshop (ICW), Kanazawa, Japan, (1190-1190). 4-8 September 2016. doi:10.1016/j.imbio.2016.06.146

Paraquat activates the NLRP3 Inflammasome in microglia via the NADPH oxidase pathway

Albornoz, E., Deora, V., Robertson, B. A., Cooper, M. A., Schroder, K., Woodruff, T. M. and Gordon, R. (2015). Paraquat activates the NLRP3 Inflammasome in microglia via the NADPH oxidase pathway. In: International Congress of Immunology (ICI), Melbourne, Australia, (1264-1264). Aug 21-26, 2016.