Professor Trent Woodruff

Professor

School of Biomedical Sciences
Faculty of Medicine
t.woodruff@uq.edu.au
+61 7 336 52924

Overview

Dr Woodruff is a Professor of Pharmacology who leads a research team aiming to find new therapeutic treatments for neurodegenerative disorders. Current therapies for these diseases are vastly inadequate, and so new research is needed to identify novel targets to slow or halt their progression. Prof Woodruff’s specific research revolves around the innate immune system in the brain, and the role of neuroinflammation in propagating disease. A key focus of his current work is testing new drugs developed at the University of Queensland in models of motor neuron disease (amyotrophic lateral sclerosis), Huntington’s disease, and Parkinson's disease, as well as maintaining an active interest in acute inflammatory disorders including sepsis and ischemia-reperfusion injuries. Using a series of potent and orally active complement C5a and NLRP3 inflammasome inhibitors developed at UQ, Prof Woodruff's team has demonstrated the therapeutic potential of targeting innate immune-mediated neuroinflammation to reduce neuronal cell death in animal models of these neurodegenerative diseases. His team has recently shown that in addition to their roles in neurodegeneration, innate immune factors also play essential roles in stem and neuronal cell development during embryogenesis, revealing the widespread physiological and pathological roles of this evolutionarily ancient immune system.

Research Interests

  • Neurodegenerative disease
    Studying new treatments to halt disease progression
  • Parkinson's disease
    Studying new treatments to halt disease progression
  • Motor neuron disease
    Studying new treatments to halt disease progression

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Science (Honours), The University of Queensland

Publications

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Supervision

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Available Projects

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Publications

Featured Publications

Book Chapter

  • Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). C3aR1. The complement FactsBook. (pp. 385-396) edited by Scott Barnum and Theresa Schein.London, United Kingdom: Elsevier. doi:10.1016/B978-0-12-810420-0.00036-5

  • Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). C5aR1. The Complement FactsBook. (pp. 397-405) edited by Scott Barnum and Theresa Schein.London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-810420-0.00037-7

  • Albornoz, Eduardo A., Woodruff, Trent M. and Gordon, Richard (2018). Inflammasomes in CNS diseases. Inflammasomes: clinical and therapeutic implications. (pp. 41-60) edited by Mario D. Cordero and Elisabet Alcocer-Gómez.Cham, Switzerland: Springer International. doi:10.1007/978-3-319-89390-7_3

  • Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2017). C5aR2. The complement FactsBook. (pp. 407-414) edited by Scott Barnum and Theresa Schein.London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-810420-0.00038-9

  • Gordon, Richard and Woodruff, Trent M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. Disease-modifying targets in neurodegenerative disorders: paving the way for disease-modifying therapies. (pp. 49-80) edited by Veerle Baekelandt and Evy Lobbestael.London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-805120-7.00003-8

  • Gordon, Richard and Woodruff, Trent M. (2017). Neuroinflammation as a therapeutic target in neurodegenerative diseases. Disease-modifying targets in neurodegenerative disorders. (pp. 43-64) edited by Veerle Baekelandt and Evy Lobbestael.Boston, MA, United States: Academic Press (Elsevier Press).

  • Lee, John D., Lee, Jia Y., Taylor, Stephen M., Noakes, Peter G. and Woodruff, Trent M. (2012). Innate immunity in ALS. Amyotrophic lateral sclerosis. (pp. 393-412) edited by Martin H. Maurer.Croatia: InTech - Open Access Publisher. doi:10.5772/30341

  • Proctor, Lavinia M., Woodruff, Trent M., Sharma, Prakirti, Shiels, Ian A., Taylor, Stephen M. and Lambris, John D. (2006). Transdermal Pharmacology of Small Molecule Cyclic C5a Antagonists. Current Topics in Complement. (pp. 329-345) edited by John D. Lambris.New York: Springer. doi:10.1007/0-387-34134-X_22

Journal Article

Conference Publication

  • Quang Huy Quach,, Johnson, Christina, Lau, Corinna, Woodruff, Trent M., Pischke, Soren E., Mollnes, Tom Eirik and Nilsson, Per H. (2019). Bacterial-induced il-8 release is dependent on c5a-05ar1 and thrombin-dependent activation of platelets in human whole blood. 17th European Meeting on Complement in Human Disease (EMCHD), Madrid, Spain, 2019. Oxford, United Kingdom :Elsevier .

  • Coughlan, M. T., Tan, S., Ziemann, M., Snelson, M., El-Osta, A., MacIsaac, R. J., Meikle, P. J., Forbes, J. M., Cooper, M. E., Ekinci, E. I. and Woodruff, T. M. (2019). Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming. 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona Spain, 16-20 September 2019. Heidelberg, Germany :Springer.

  • Nabizadeh, J., Manthey, H., Panagides, N., Steyn, F., Lee, J., Li, X., Woodruff, T. and Rolfe, B. (2019). Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma. 17th International Congress of Immunology (IUIS), Beijing, China, 19-23 October 2019. Weinheim, Germany :Wiley.

  • Silva-de-Franca, Felipe, Villas-Boas, Isadora, Cogliati, Bruno, Woodruff, Trent, da-Silva-Reis, Edimara, Lambris, John and Tambourgi, Denise (2019). Complement Inhibition: A Possible Therapeutic Strategy For Controlling Cobra Envenomation. 17th European Meeting on Complement in Human Disease (EMCHD), Madrid, Spain, 2019. Oxford, United Kingdom :Elsevier .

  • Beurskens, Frank, de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane, Shaughnessy, Jutamas, Taylors, Ronald, Botto, Marina, He, Xianbao, Ingalls, Robin, Woodruff, Trent, Song, Wen-Chao, Schuurman, Janine, Rice, Peter and Ram, Sanjay (2019). Complement alone drives efficacy of a chimeric anti-gonococcal monoclonal antibody. 17th European Meeting on Complement in Human Disease (EMCHD), Madrid, Spain, 2019. Oxford, United Kingdom :Elsevier .

  • Woodruff, T., Hawksworth, O., Lee, J. and Coulthard, L. (2019). Deciphering key roles for complement peptide receptors in brain development. Joint Meeting of the International Society for Neurochemistry and American Society for Neurochemistry (ISN-ASN), Montreal, Canada, 4-8 August 2019. Chichester, West Sussex, United Kingdom :Wiley-Blackwell.

  • Silva-de-Franca, Felipe, Villas-Boas, Isadora, Cogliati, Bruno, Woodruff, Trent and Tambourgi, Denise (2018). Complement activation contributes to the pathogenesis of African cobra envenomation. 27th International Complement Workshop (ICW), Santa Fe Nm, Sep 16-20, 2018. OXFORD :PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2018.06.220

  • Ong, Voon, Arbore, Giuseppina, Costantini, Benedetta, Abrahams, David, Denton, Christopher, Placais, Leo, Mitchell, Lynne, Ellis, Richard, Heck, Susanne, Woodruff, Trent, Kordasti, Shahram, Kemper, Claudia and Hourcade, Dennis (2018). Mass cytometry analysis detects dysregulated T cell complement responses in scleroderma patients. 27th International Complement Workshop (ICW), Santa Fe Nm, Sep 16-20, 2018. OXFORD :PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2018.06.098

  • Muenstermann, Marcel, Herrmann, Johannes, Strobel, Lea, Woodruff, Trent, Klos, Andreas, Wetsel, Rick, Gerard, Craig, Koehl, Joerg and Johswich, Kay Ole (2018). The distinct roles of the anaphylatoxin receptors C5aR1, C5aR2 and C3aR during experimental invasive meningococcal disease. 27th International Complement Workshop (ICW), Santa Fe Nm, Sep 16-20, 2018. OXFORD :PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2018.06.109

  • West, Erin E., Freeley, Simon, Kolev, Martin, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik, Lappegard, Knut, Woodruff, Trent M., Monk, Peter N. and Kemper, Claudia (2018). Auto-regulation of Th1 responses requires intracellular carboxypeptidase M-mediated complement regulation. 27th International Complement Workshop (ICW), Santa Fe, NM, United States, 16-20 September 2018. Kidlington, Oxford, United Kingdom :Pergamon Press. doi: 10.1016/j.molimm.2018.06.246

  • Gordon, Richard, Albornoz, Eduardo, Kanthasamy, Anumantha and Woodruff, Trent (2018). C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation. 27th International Complement Workshop (ICW), Santa Fe, NM, United States, Sep 16-20, 2018. Kidlington, Oxford, United Kingdom :Pergamon Press. doi: 10.1016/j.molimm.2018.06.247

  • Coughlan, M. T., Tan, S. M., Ekinci, E. I., Snelson, M., Penfold, S. A., Higgins, G. C., Lindblom, R. S., Sourris, K. C., Thallas-Bonke, V., Jerums, G., Skene, A., Power, D. A., MacIsaac, R. J., Cooper, M. E. and Woodruff, T. M. (2017). Targeting the C5a-C5aR1 signalling axis in diabetic kidney disease. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon Portugal, Sep 11-15, 2017. NEW YORK :SPRINGER.

  • Christiansen, Dorte, Skjeflo, Espen Waage, Landsem, Anne, Fure, Hilde, Ludviksen, Judith K., Stenvik, Jurgen, Woodruff, Trent, Espevik, Terje and Mollnes, Tom Eirik (2017). Combined C5aR1 and CD14 inhibition significantly reduced cytokine release induced by both viable and heat inactivated bacteria in human whole blood. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, Sep 08-12, 2017. PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.molimm.2017.06.147

  • Woodruff, Trent M., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Leel, John D., Sepehrband', Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Coulthard, Liam G. (2017). Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brain. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, 8-12 September 2017. Kidlington, Oxford United Kingdom :Pergamon Press. doi: 10.1016/j.molimm.2017.06.178

  • Magalhaes, Ricardo J. Soares, Giacomin, Paul, Sarnyay, Zoltan, Kraeuter, Ann, Urich, Tim, Bengtsson, Mia, Jin, Shuting, Albornoz, Eduardo A., Gordon, Richard and Woodruff, Trent (2017). Gut microbiome changes induced by experimental trichuris muris infection are associated with decreased cognitive function in mice. 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), Atlanta, GA, United States, 13-16 November 2016. Deerfield, United States :American Society of Tropical Medicine and Hygiene.

  • Deora, Vandana, Mantovani, Susanna, Yerbury, Justin, Clark, Richard, Atkin, Julie, Lee, John, Gordon, Richard and Woodruff, Trent M. (2017). Motor neuron disease proteins activate complement and generate C5a. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen, Denmark, 8-12 September 2017. Kidlington, Oxford, United Kingdom :Pergamon Press. doi: 10.1016/j.molimm.2017.06.144

  • Li, Rui, Lee, John D., Levin, Samantha, Gordon, Richard and Woodruff, Trent M. (2016). A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's disease. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany :Elsevier. doi: 10.1016/j.imbio.2016.06.186

  • Freeley, Simon, Le Friec, Gaelle, Kolev, Martin, Niyonzima, Nathalie, Espevik, Terje, Mollnes, Tom Eirik, Lappegard, Knut, Woodruff, Trent M., Monk, Pete and Kemper, Claudia (2016). Auto-regulation of Th1 responses through carboxypeptidase M-generated C5a-desArg. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany :Elsevier. doi: 10.1016/j.imbio.2016.06.120

  • West, Erin E., Arbore, Giuseppina, Robertson, Avril A. B., Klos, Andreas, Woodruff, Trent M., O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Joerg, Monk, Pete, Cooper, Matthew A., Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin and Kemper, Claudia (2016). Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4(+) T cells. Annual Meeting of the American Association of Immunologists (AAI), Seattle, WA, United States, 13-17 May 2016. Bethesda, MD, United States :American Association of Immunologists.

  • Gordon, Richard, Albornoz, Eduardo A., Kumar, Vinod, Zhou, Kiane, Garin-Michaud, Ashoka, Mantavani, Susanna, Kanthasamy, Anumantha G. and Woodruff, Trent M. (2016). Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany :Elsevier. doi: 10.1016/j.imbio.2016.06.146

  • Kumar, V., Woodruff, T., Ting, M., Boyd, A., Coulthard, M., Souza-Fonseca-Guimaraes, F. and Smyth, M. (2016). EphA2KO mice survive longer in a mouse model of sepsis. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany :Wiley - VCH. doi: 10.1002/eji.201670200

  • Biggins, P. J. C., Brennan, F. H., Taylor, S. M., Woodruff, T. M. and Ruitenberg, M. J. (2016). Investigating the role of complement component C5a receptor 2 (C5aR2/C5L2) in spinal cord injury. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany :Elsevier. doi: 10.1016/j.imbio.2016.06.058

  • Li, R., Levin, S., Lee, J., Gordon, R. and Woodruff, T. (2016). The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's disease. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany :Wiley - VCH. doi: 10.1002/eji.201670200

  • Christiansen, Dorte, Skjeflo, Espen Waage, Landsem, Anne, Mathisen, Monica Dammen, Fure, Hilde, Stenvik, Jorgen, Woodruff, Trent, Espevik, Terje and Mollnes, Tom Eirik (2016). The effect of combined inhibition of C5aR1 and CD14 on phagocytosis of E. coli in human whole blood. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany :Elsevier. doi: 10.1016/j.imbio.2016.06.212

  • Kumar, Vinod, Lee, John, Noakes, Peter and Woodruff, Trent (2015). Blood brain barrier impairment alters the pharmacokinetic properties of the complement C5aR1 antagonist PMX205 in mouse models of neurodegeneration. 8th International Conference on Complement Therapeutics, Chania, Crete, Greece, 1-6 January 2015.

  • Tan, S. M., Nguyen, T. V., Woodruff, T. M. and Coughlan, M. T. (2015). Investigating the role of C5a-CD88 signalling axis in diabetic nephropathy. 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September, 2015. Richmond, Australia :Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12543

  • Albornoz, E., Deora, V., Robertson, B. A., Cooper, M. A., Schroder, K., Woodruff, T. M. and Gordon, R. (2015). Paraquat activates the NLRP3 Inflammasome in microglia via the NADPH oxidase pathway. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany :Wiley-Blackwell.

  • Mantovani, S., Gordon, R., Ngo, S., Pfluger, C., O'Sullivan, J., Noakes, P., Henderson, R., McCombe, P. and Woodruff, T. (2015). Peripheral immune complement activation in neurodegenerative disease. 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom :Wiley-Blackwell. doi: 10.1111/jnc.13188

  • Reiner, O., Gorelik, A., Sapir, T., Bialas, A. R., Stevens, B., Woodruff, T. M. and Haffner-Krausz, R. (2015). Unexpected activities of the complement pathway in migrating neurons. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom :Wiley-Blackwell Publishing. doi: 10.1111/jnc.13185

  • Ruitenberg, Marc J., Brennan, Faith H., Gordon, Richard, Blomster, Linda V., Lao, Hong Wa, Cowin, Gary J., Taylor, Stephen M. and Woodruff, Trent M. (2014). Acute Antagonism of the Complement Anaphylatoxin Receptor C5Ar Improves the Outcome From Experimental Spinal Cord Injury. 11th Symposium of the International-Neurotrauma-Society, Budapest, Hungary, 19-23 March 2014. New Rochelle, NY United States :Mary Ann Liebert.

  • Woodruff, Trent M. (2014). C3a and C5a homeostasis in health and disease. 25th International Complement Workshop, Rio de Janeiro Brazil, 14-18 September 2014. Kidlington, Oxford, United Kingdom :Pergamon Press.

  • Croker, Daniel E., Halai, Reena, Kaeslin, Geraldine, Morikis, Dimitrios, Woodruff, Trent, Floudas, Christodoulos A., Monk, Peter N. and Cooper, Matthew A. (2014). Discovery of novel selective C5a2 ligands that can modulate IL-6 releAse from macrophages. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne Australia, Oct 26-29, 2014. London United Kingdom :Academic Press. doi: 10.1016/j.cyto.2014.07.039

  • Mantovani, S., Li, R., Gordon, R., Kumar, V., Taylor, S. and Woodruff, T. M. (2013). Behavioural and pathological phenotyping of the C57BL/6J BACHD transgenic mouse model of Huntington’s disease. World Congress on Huntington’s disease, Rio de Janeiro, Brazil, 15-18 September 2013. Amsterdam, Netherlands :I O S Press.

  • Barrett, Helen L., Mcintyre, H. David, Denny, Kerina, Woodruff, Trent, Callaway, Leonie K. and Nitert, Marloes Dekker (2013). Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM). American Diabetes Association 73rd Scientific Sessions, Chicago, IL United States, 21-25 June 2013 . Arlington, VA United States :American Diabetes Association. doi: 10.2337/db13-1-387

  • Jain, Umang, Woodruff, Trent and Stadnyk, Andrew (2012). Antagonizing C5aR reduces T Cell- IL-10-dependent colitis in pre-clinical models. 2012 Advances in Inflammatory Bowel Diseases Crohn’s & Colitis Foundation’s National Clinical & Research Conference, Hollywood, Fl, United States, 13-15 December 2012. Philadelphia, PA, United States :Lippincott Williams & Wilkins. doi: 10.1002/ibd.23058

  • Monkl, Peter N., Bellows-Peterson, Meghan L., Smadbeck, James, Floudas, Christodoulos A., Kieslich, Christopher A., Morikis, Dimitrios and Woodruff, Trent M. (2012). De novo protein design of agonists and antagonists of C5a receptors. 24th International Complement Workshop (ICW), Chania, Crete, Greece, 10-15 October 2012. Jena, Germany :Urban und Fischer Verlag. doi: 10.1016/j.imbio.2012.08.097

  • Brennan, Faith H., Blomster, Linda V., Costantini, Alexander M., Taylor, Stephen M., Woodruff, Trent M. and Ruitenberg, Marc J. (2012). Deficiency of the complement anaphylatoxin receptor C3aR on leukocytes worsens the outcome from spinal cord injury by promoting neutrophilia. 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, 4-8 November 2012. Amsterdam, The Netherlands :Elsevier.

  • Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2012). Expression of complement factors and functional C5a receptors in human embryonic stem cells, and induced pluripotent stem cells. 24th International Complement Workshop (ICW), Chania, Crete, Greece, 10-15 October 2012. Jena, Germany :Urban und Fischer Verlag. doi: 10.1016/j.imbio.2012.08.116

  • Woodruff, Trent M., Wu, Mike C. L., Brennan, Faith H., Wetsel, Rick A., Ruitenberg, Marc J. and Taylor, Stephen M. (2012). The C3a receptor mediates protection from intestinal ischemia reperfusion injuries by impairing neutrophil mobilization. 24th International Complement Workshop (ICW), Chania, Crete, Greece, 10-15 October 2012. Jena, Germany :Urban und Fischer Verlag. doi: 10.1016/j.imbio.2012.08.229

  • Pavlovski, D., Thundyil, J., Taylor, S. M., Arumugam, T., V and Woodruff, T. M. (2012). The complement receptors CD88, C5L2 and C3AR mediate inflammatory injury following transient cerebral ischemia. Stroke 2012 Conference - A combined event of the Stroke Society of Australasia 2012 Annual Scientific Meeting and the 8th Smart Strokes Australasian Nursing and Allied Health Stroke Conference, Sydney NSW Australia, 29-31 August 2012. Richmond, VIC Australia :Wiley-Blackwell Publishing Asia.

  • Costantini, K. J., Coulthard, L. G. J., Lor, Mary, Woodruff, T. M., Callaway, L. K., Finnell, R. H. and Taylor, S. M. (2010). C5aR protects against folate-deficiency induced neural tube defects in mice. XXIII International Complement Workshop, New York, NY, U.S.A., 1-5 August 2010. Oxford, U.K. :Pergamon Press. doi: 10.1016/j.molimm.2010.05.169

  • Coulthard, L. G. J., Costantini, K. J., Lor, Mary, Simmons, D., Taylor, S. M. and Woodruff, T. M. (2010). Complement expression in mice throughout neural tube closure. XXIII International Complement Workshop, New York, NY, U.S.A., 1-5 August 2010. Oxford, U.K. :Pergamon Press. doi: 10.1016/j.molimm.2010.05.163

  • Woodruff, T. M., Lee, J. D., Taylor, S. M. and Noakes, P. G. (2010). Dysregulation of the complement system in neurodegenerative disease. XXIII International Complement Workshop, New York, NY, U.S.A., 1-5 August 2010. Oxford, U.K. :Pergamon Press. doi: 10.1016/j.molimm.2010.05.215

  • Wu, M. C. L., Moore, T. A., Manthey, H. D., Taylor, S. M. and Woodruff, T. M. (2010). The role of complement anaphylatoxin receptors in mesenteric ischemia/reperfusion-induced injury. XXIII International Complement Workshop, New York, NY, U.S.A., 1-5 August 2010. Oxford, U.K. :Pergamon Press. doi: 10.1016/j.molimm.2010.05.216

  • Costantini, K. J., Coulthard, L. G., Woodruff, T. M., Taylor, S. M. and Callaway, L. K. (2010). The role of complement-mediated inflammation in miscarriage and preterm birth. XXIII International Complement Workshop, New York, NY, U.S.A., 1-5 August 2010. Oxford, U.K. :Pergamon Press. doi: 10.1016/j.molimm.2010.05.222

  • Woodruff, Trent, Denny, Kerina, Crane, James, Atkin, Julie, Taylor, Steve and Noakes, Peter (2008). Blockade of C5a receptors reduces astroglial inflammation in a rat SOD1G93A model of amyotrophic lateral sclerosis. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, 28 September-02 October 2008. doi: 10.1016/j.molimm.2008.08.202

  • Beck, K. D., Nguyen, H. X., Woodruff, T. M. and Anderson, A. J. (2008). Chronic complement-mediated inflammation promotes recovery after spinal cord injury. American Society for Neurochemistry 39th Annual Meeting, San Antonio, United States, 1-5 March 2008. Chichester, West Sussex, United Kingom :Wiley-Blackwell. doi: 10.1111/j.1471-4159.2008.05160.x

  • Moore, Tyson, Woodruff, Trent, Manthey, Helga, Monk, Peter, Taylor, Stephen and Shiels, Ian (2008). Novel Haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, 28 September-2 October 2008. Oxford, United Kingdom :Elseiver. doi: 10.1016/j.molimm.2008.08.165

  • Manthey, Helga, Thomas, Anita, Taylor, Stephen, Woodruff, Trent, Moore, Tyson, Shiels, Ian and Rolfe, Barbara (2008). Protective effects of C5a receptor antagonism in a mouse model of atherosclerosis. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, 28 September - 2 October 2008. Oxford, United Kingdom :Elsevier. doi: 10.1016/j.molimm.2008.08.167

  • Woodruff, Trent R., Costantini, Kerina J., Taylor, Steve M. and Noakes, Peter G. (2008). Role of complement in motor neuron disease: Animal models and therapeutic potential of complement inhibitors. 4th Aegean Workshop on Complement Associated Diseases, Animal Models and Therapeutics, Porto Heli, Greece, 10-17 June 2007. New York, United States :Springer New York LLC. doi: 10.1007/978-0-387-78952-1_11

  • Denny, Kerina, Woodruff, Trent, Pavlovski, Dale, Manthey, Helga, Paul Colditz, Richard Finnell and Stephen Taylor (2008). The role of C5a in reproductive impairment in the mouse and human. ICW Basel, XXII International Complement Workshop, Basel, Switzerland, 28 September - 2 October 2008. Oxford, United Kingdom :Elsevier. doi: 10.1016/j.molimm.2008.08.164

  • Woodruff, T. M., Proctor, L. M., Shiels, I. A. and Taylor, S. M. (2004). A cyclic peptide, C5a receptor antagonist analogue confers increased potency in a model of inflammatory bowel disease in rats. 20th International Complement Workshop, Honolulu, Hawaii, 13-18 June, 2004. Oxford ; New York :Pergamon Press. doi: 10.1016/j.molimm.2004.03.002

  • Proctor, L.M., Woodruff, T.M., Pazckowski, N.P., Monk, P.N. and Taylor, S.M. (2004). Dual C3a/C5a receptor agonism by a C5a C-terminal analogue decapeptide. 20th International Complement Workshop, Honolulu, Hawaii, 13-18 June, 2004. Oxford ; New York :Pergamon Press. doi: 10.1016/j.molimm.2004.03.002

  • Woodruff, T. M., Shiels, I. A., Fairlie, D. and Taylor, S. M. (2001). A new C5a receptor antagonist inhibits monoarticular arthritis in the rat. Complement Assoc. Diseases, Animal Models & Ther. Workshop, Santorini, Greece, 10-14 October, 2001. Aegean Conferences.

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.