The University of Queensland

Lentiviral reprogramming of A-T patient fibroblasts to induced pluripotent stem cells

Nayler, Sam, Kozlov, Sergei V., Lavin, Martin F. and Wolvetang, Ernst (2017). Lentiviral reprogramming of A-T patient fibroblasts to induced pluripotent stem cells. In Sergei V. Kozlov (Ed.), ATM kinase: methods and protocols (pp. 401-418) New York, NY, United States: Humana Press; Springer Science+Business Media. doi:10.1007/978-1-4939-6955-5_29

Ascorbate as a modulator of the epigenome

Thakar, Nilay Y. and Wolvetang, Ernst J. (2015). Ascorbate as a modulator of the epigenome. Nutrition and epigenetics. (pp. 199-218) edited by Emily Ho and Frederick Domann. Boca Raton, FL, United States: CRC Press. doi: 10.1201/b17530-11

Development of defined culture conditions for expansion of human mesenchymal stromal cells for clinical applications

Frith, Jessica E., Jaramillo-Ferrada, Pamela, Mills, Richard J., Cameron, Andrew R., Titmarsh, Drew M., Wolvetang, Ernst J. and Cooper-White, Justin J. (2012). Development of defined culture conditions for expansion of human mesenchymal stromal cells for clinical applications. Stem cells and cancer stem cells: therapeutic applications in disease and injury. (pp. 13-26) edited by M. A. Hayat. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-94-007-4798-2_2

Smads: The intracellular hubs of signalling in regulation of pluripotency and differentiation of stem cells

Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2011). Smads: The intracellular hubs of signalling in regulation of pluripotency and differentiation of stem cells. Embryonic stem cells: The hormonal regulation of pluripotency and embryogenesis. (pp. 191-216) edited by Craig Atwood. Vienna, Austria: Intech Open Access.

Protocol for generating embedding-free brain organoids enriched with oligodendrocytes

Al-mhanawi, Bahaa, Marti, Marta Boira, Morrison, Sean D., Gupta, Pallavi, Alani, Maath, Noakes, Peter G., Wolvetang, Ernst J. and Shaker, Mohammed R. (2023). Protocol for generating embedding-free brain organoids enriched with oligodendrocytes. STAR Protocols, 4 (4) 102725, 102725. doi: 10.1016/j.xpro.2023.102725

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Aguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 1-15. doi: 10.1038/s43587-023-00519-6

CRISPR-Cas9 Direct Fusions for Improved Genome Editing via Enhanced Homologous Recombination

Tabassum, Tahmina, Pietrogrande, Giovanni, Healy, Michael and Wolvetang, Ernst J. (2023). CRISPR-Cas9 Direct Fusions for Improved Genome Editing via Enhanced Homologous Recombination. International Journal of Molecular Sciences, 24 (19) 14701, 14701. doi: 10.3390/ijms241914701

Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation

Tracey, Timothy J., Jiang, Leanne, Gill, Melinder K., Ranie, Samara N., Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Ngo, Shyuan T. (2023). Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation. Stem Cell Research, 70 103137, 1-6. doi: 10.1016/j.scr.2023.103137

Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution

Taherian Fard, Atefeh, Leeson, Hannah C., Aguado, Julio, Pietrogrande, Giovanni, Power, Dominique, Gómez-Inclán, Cecilia, Zheng, Huiwen, Nelson, Christopher B., Soheilmoghaddam, Farhad, Glass, Nick, Dharmaratne, Malindrie, Watson, Ebony R., Lu, Jennifer, Martin, Sally, Pickett, Hilda A., Cooper-White, Justin, Wolvetang, Ernst J. and Mar, Jessica C. (2023). Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. GeroScience, 1-17. doi: 10.1007/s11357-023-00829-y

Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2

Shaker, Mohammed R., Slonchak, Andrii, Al-mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D. J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2023). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. bioRxiv. doi: 10.1101/2023.06.12.544552

Cellular senescence and premature aging in Down Syndrome

Peng, Lianli, Baradar, Alireza A., Aguado, Julio and Wolvetang, Ernst (2023). Cellular senescence and premature aging in Down Syndrome. Mechanisms of Ageing and Development, 212 111824, 111824. doi: 10.1016/j.mad.2023.111824

Noncoding RNA of Zika virus affects interplay between Wnt-signaling and pro-apoptotic pathways in the developing brain tissue

Slonchak, Andrii, Chaggar, Harman, Aguado, Julio, Wolvetang, Ernst and Khromykh, Alexander A. (2023). Noncoding RNA of Zika virus affects interplay between Wnt-signaling and pro-apoptotic pathways in the developing brain tissue. Viruses, 15 (5) 1062, 1062. doi: 10.3390/v15051062

Embryonic Stem Cell-Derived Neurons as a Model System for Epigenome Maturation during Development

Martin, Sally, Poppe, Daniel, Olova, Nelly, O’Leary, Conor, Ivanova, Elena, Pflueger, Jahnvi, Dechka, Jennifer, Simmons, Rebecca K., Cooper, Helen M., Reik, Wolf, Lister, Ryan and Wolvetang, Ernst J. (2023). Embryonic Stem Cell-Derived Neurons as a Model System for Epigenome Maturation during Development. Genes, 14 (5) 957, 957. doi: 10.3390/genes14050957

Muscle and Its Neuromuscular Synapse – Players in the Pathogenesis of Motor Neuron Disease

Noakes, Peter G., Phillips, William D., Jeffree, Rosalind L., Steyn, Frederik J., Wolvetang, Ernst J., Henderson, Rob D., McCombe, Pamela A. and Ngo, Shyuan T. (2023). Muscle and Its Neuromuscular Synapse – Players in the Pathogenesis of Motor Neuron Disease. Journal of Experimental Neurology, 4 (1), 1-5. doi: 10.33696/neurol.4.067

Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: A repurposing study

Ribaudo, Giovanni, Yun, Xiaoyun, Ongaro, Alberto, Oselladore, Erika, Ng, Jerome P. L., Haynes, Richard K., Law, Betty Yuen Kwan, Memo, Maurizio, Wong, Vincent Kam Wai, Coghi, Paolo and Gianoncelli, Alessandra (2022). Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: A repurposing study. Chemical Biology & Drug Design, 101 (4), 809-818. doi: 10.1111/cbdd.14187

Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis

Slonchak, Andrii, Wang, Xiaohui, Aguado, Julio, Sng, Julian D. J., Chaggar, Harman, Freney, Morgan E., Yan, Kexin, Torres, Francisco J., Amarilla, Alberto A., Balea, Rickyle, Setoh, Yin Xiang, Peng, Nias, Watterson, Daniel, Wolvetang, Ernst, Suhrbier, Andreas and Khromykh, Alexander A. (2022). Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis. Science Advances, 8 (48) eadd8095, eadd8095. doi: 10.1126/sciadv.add8095

Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7)

Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2022). Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7). Nature Communications, 13 (1) 1200. doi: 10.1038/s41467-022-28758-y

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2022). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 1-16. doi: 10.1038/s41380-022-01831-0

<i>Poria cocos</i> polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in Apc<SUP><i>Min/</i>+</SUP> mice

Yin, Lin, Huang, Guoxin, Khan, Imran, Su, Lu, Xia, Wenrui, Law, Betty Yuen Kwan, Wong, Vincent Kam Wai, Wu, Qiang, Wang, Jingyi, Leong, Wai Kit and Hsiao, W. L. Wendy (2022). Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in ApcMin/+ mice. Chinese Medicine, 17 (1) ARTN 116. doi: 10.1186/s13020-022-00667-8

Generation of human induced pluripotential stem cells from individuals with complex heterozygous, isogenic corrected, and homozygous Bloc1s1 mutations

Wu, Kaiyuan, Takanohashi, Asako, Woidill, Sarah, Seylani, Allen, Helman, Guy, Dias, Patricia, Beers, Jeanette, Lin, Yongshun, Simons, Cas, Wolvetang, Ernst, Zou, Jizhong, Vanderver, Adeline and Sack, Michael N. (2022). Generation of human induced pluripotential stem cells from individuals with complex heterozygous, isogenic corrected, and homozygous Bloc1s1 mutations. Stem Cell Research, 64 102905, 1-6. doi: 10.1016/j.scr.2022.102905

Generation of iPSC lines from hereditary spastic paraplegia 56 (SPG56) patients and family members carrying CYP2U1 mutations

Leeson, Hannah C., Goh, Denise, Coman, David and Wolvetang, Ernst J. (2022). Generation of iPSC lines from hereditary spastic paraplegia 56 (SPG56) patients and family members carrying CYP2U1 mutations. Stem Cell Research, 64 102917, 1-5. doi: 10.1016/j.scr.2022.102917

The hallmarks of aging in ataxia-telangiectasia

Aguado, Julio, Gómez-Inclán, Cecilia, Leeson, Hannah C., Lavin, Martin F., Shiloh, Yosef and Wolvetang, Ernst J. (2022). The hallmarks of aging in ataxia-telangiectasia. Ageing Research Reviews, 79 101653, 1-15. doi: 10.1016/j.arr.2022.101653

Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants

Isaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262

Robust and highly reproducible generation of cortical brain organoids for modelling brain neuronal senescence in vitro

Shaker, Mohammed R., Hunter, Zoe L. and Wolvetang, Ernst J. (2022). Robust and highly reproducible generation of cortical brain organoids for modelling brain neuronal senescence in vitro. Journal of Visualized Experiments, 2022 (183) e63714. doi: 10.3791/63714

Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3? protein

Gao, Zhenxiong, Fan, Tingting, Chen, Linbo, Yang, Mengchu, Wong, Vincent Kam Wai, Chen, Dawei, Liu, Zijian, Zhou, Yaoyao, Wu, Weibin, Qiu, Zixuan, Zhang, Cunlong, Li, Yuan and Jiang, Yuyang (2022). Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3? protein. European Journal of Medicinal Chemistry, 238 ARTN 114402. doi: 10.1016/j.ejmech.2022.114402

Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

Ding, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5

Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

Hunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J. and Vadlamudi, Lata (2022). Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening. Stem Cell Research, 60 102673, 102673. doi: 10.1016/j.scr.2022.102673

Exploring aging interventions in human brain organoids

Aguado, Julio and Wolvetang, Ernst J (2022). Exploring aging interventions in human brain organoids. Aging, 14 (4), 1592-1593. doi: 10.18632/aging.203925

Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell types

Shaker, Mohammed R., Kahtan, Amna, Prasad, Renuka, Lee, Ju-Hyun, Pietrogrande, Giovanni, Leeson, Hannah C., Sun, Woong, Wolvetang, Ernst J. and Slonchak, Andrii (2022). Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell types. Frontiers in Cell and Developmental Biology, 10 803061, 803061. doi: 10.3389/fcell.2022.803061

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2021). Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network. Nature Communications, 12 (1) 3297. doi: 10.1038/s41467-021-23143-7

Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated <i>in vivo</i> tumor growth

Mahmoud, Nuha, Dawood, Mona, Huang, Qi, Ng, Jerome P. L., Ren, Fang, Wong, Vincent K. W. and Efferth, Thomas (2021). Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor growth. Phytomedicine, 94 ARTN 153826, 153826. doi: 10.1016/j.phymed.2021.153826

Ataxia Telangiectasia iPSC line generated from a patient olfactory biopsy identifies novel disease-causing mutations

Leeson, Hannah C., Hunter, Zoe, Chaggar, Harman Kaur, Lavin, Martin F., Mackay-Sim, Alan and Wolvetang, Ernst J. (2021). Ataxia Telangiectasia iPSC line generated from a patient olfactory biopsy identifies novel disease-causing mutations. Stem Cell Research, 56 102528, 102528. doi: 10.1016/j.scr.2021.102528

Generation of induced pluripotent stem cell lines from peripheral blood mononuclear cells of three drug resistant and three drug responsive epilepsy patients

Hunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J. and Vadlamudi, Lata (2021). Generation of induced pluripotent stem cell lines from peripheral blood mononuclear cells of three drug resistant and three drug responsive epilepsy patients. Stem Cell Research, 56 102564, 102564. doi: 10.1016/j.scr.2021.102564

Reprogramming of human olfactory neurosphere-derived cells from olfactory mucosal biopsies of a control cohort

Leeson, Hannah C., Hunter, Zoe, Chaggar, Harman Kaur, Mackay-Sim, Alan and Wolvetang, Ernst J. (2021). Reprogramming of human olfactory neurosphere-derived cells from olfactory mucosal biopsies of a control cohort. Stem Cell Research, 56 102527, 102527. doi: 10.1016/j.scr.2021.102527

Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids

Aguado, Julio, Chaggar, Harman K., Gómez‐Inclán, Cecilia, Shaker, Mohammed R., Leeson, Hannah C., Mackay‐Sim, Alan and Wolvetang, Ernst J. (2021). Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids. Aging Cell, 20 (9) e13468, 1-16. doi: 10.1111/acel.13468

Klotho inhibits neuronal senescence in human brain organoids

Shaker, Mohammed R., Aguado, Julio, Chaggar, Harman Kaur and Wolvetang, Ernst J. (2021). Klotho inhibits neuronal senescence in human brain organoids. npj Aging and Mechanisms of Disease, 7 (1) 18, 1-12. doi: 10.1038/s41514-021-00070-x

TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells

Ding, Qiao, Chaplin, Justin, Morris, Matthew J., Hilliard, Massimo A., Wolvetang, Ernst, Ng, Dominic C. H. and Noakes, Peter G. (2021). TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells. Frontiers in Cell and Developmental Biology, 9 611601, 611601. doi: 10.3389/fcell.2021.611601

Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines

Alharbi, Samah Abdulaali, Ovchinnikov, Dmitry A. and Wolvetang, Ernst (2021). Leucine-rich repeat-containing G protein-coupled receptor 5 marks different cancer stem cell compartments in human Caco-2 and LoVo colon cancer lines. World Journal of Gastroenterology, 27 (15), 1578-1594. doi: 10.3748/WJG.V27.I15.1578

Rapid and efficient generation of myelinating human oligodendrocytes in organoids

Shaker, Mohammed R., Pietrogrande, Giovanni, Martin, Sally, Lee, Ju-Hyun, Woong, Sun and Wolvetang, Ernst J. (2021). Rapid and efficient generation of myelinating human oligodendrocytes in organoids. Frontiers in Cellular Neuroscience, 15 631548, 1-11. doi: 10.3389/fncel.2021.631548

Antiplasmodial and antileishmanial flavonoids from <i>Mundulea sericea</i>

Chepkirui, Carolyne, Ochieng, Purity J., Sarkar, Biswajyoti, Hussain, Aabid, Pal, Chiranjib, Yang, Li Jun, Coghi, Paolo, Akala, Hoseah M., Derese, Solomon, Ndakala, Albert, Heydenreich, Matthias, Wong, Vincent K. W., Erdelyi, Mate and Yenesew, Abiy (2021). Antiplasmodial and antileishmanial flavonoids from Mundulea sericea. Fitoterapia, 149 ARTN 104796. doi: 10.1016/j.fitote.2020.104796

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

Yeo, Abrey J., Kok, Chong L., Gatei, Magtouf, Zou, Dongxiu, Stewart, Romal, Withey, Sarah, Wolvetang, Ernst, Parton, Robert G., Brown, Adam D., Kastan, Michael B., Coman, David and Lavin, Martin F. (2021). Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia. iScience, 24 (1) 101972, 101972. doi: 10.1016/j.isci.2020.101972

Testing the correlates of consciousness in brain organoids: how do we know and what do we do?

Ankeny, Rachel A. and Wolvetang, Ernst (2021). Testing the correlates of consciousness in brain organoids: how do we know and what do we do?. The American Journal of Bioethics, 21 (1), 51-53. doi: 10.1080/15265161.2020.1845869

Self-organizing 3D human choroid plexus-ventricle-cortical organoids

Shaker, Mohammed R. , Cooper-White, Justin and Wolvetang, Ernst J. (2020). Self-organizing 3D human choroid plexus-ventricle-cortical organoids.

Direct comparison of four hematopoietic differentiation methods from human induced pluripotent stem cells

Tursky, Melinda L., Loi, To Ha, Artuz, Crisbel M., Alateeq, Suad, Wolvetang, Ernst J., Tao, Helen, Ma, David D. and Molloy, Timothy J. (2020). Direct comparison of four hematopoietic differentiation methods from human induced pluripotent stem cells. Stem Cell Reports, 15 (3), 735-748. doi: 10.1016/j.stemcr.2020.07.009

Telomere transcription in Ageing

Aguado, Julio, d’Adda di Fagagna, Fabrizio and Wolvetang, Ernst (2020). Telomere transcription in Ageing. Ageing Research Reviews, 62 101115, 101115. doi: 10.1016/j.arr.2020.101115

Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P-Glycoprotein ABCB5

Yaremenko, Ivan A., Coghi, Paolo, Prommana, Parichat, Qiu, Congling, Radulov, Peter S., Qu, Yuanqing, Belyakova, Yulia Yu., Zanforlin, Enrico, Kokorekin, Vladimir A., Wu, Yuki Yu Jun, Fleury, Fabrice, Uthaipibull, Chairat, Wong, Vincent Kam Wai and Terent'ev, Alexander O. (2020). Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P-Glycoprotein ABCB5. Chemmedchem, 15 (13), 1118-1127. doi: 10.1002/cmdc.202000042

Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3β/p65 pathway

Tao, Na-Na, Zhang, Zhen-Zhen, Ren, Ji-Hua, Zhang, Juan, Zhou, Yu-Jiao, Wong, Vincent Kam Wai, Law, Betty Yuen Kwan, Cheng, Sheng-Tao, Zhou, Hong-Zhong, Chen, Wei-Xian, Xu, Hong-Mei and Chen, Juan (2020). Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3β/p65 pathway. Cancer Letters, 481, 1-14. doi: 10.1016/j.canlet.2020.03.028

Use of human induced pluripotent stem cells and kidney organoids to develop a cysteamine/mTOR inhibition combination therapy for cystinosis

Hollywood, Jennifer A., Przepiorski, Aneta, D'Souza, Randall F., Sreebhavan, Sreevalsan, Wolvetang, Ernst J., Harrison, Patrick T., Davidson, Alan J. and Holm, Teresa M. (2020). Use of human induced pluripotent stem cells and kidney organoids to develop a cysteamine/mTOR inhibition combination therapy for cystinosis. Journal of the American Society of Nephrology , 31 (5), 962-982. doi: 10.1681/ASN.2019070712

Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses

Ovchinnikov, Dmitry A., Withey, Sarah L., Leeson, Hannah C., Lei, U. Wang, Sundarrajan, Ashmitha, Junday, Keerat, Pewarchuk, Michelle, Yeo, Abrey J., Kijas, Amanda W., Lavin, Martin F. and Wolvetang, Ernst J. (2020). Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses. Human Molecular Genetics, 29 (6), 990-1001. doi: 10.1093/hmg/ddaa023

Induced pluripotent stem cell-derived mesenchymal stem cells from the Tasmanian devil (Sarcophilus harrisii) express immunomodulatory factors and a tropism toward devil facial tumor cells

Weeratunga, Prasanna, Shahsavari, Arash, Fennis, Evelien, Wolvetang, Ernst J., Ovchinnikov, Dmitry A. and Whitworth, Deanne J. (2020). Induced pluripotent stem cell-derived mesenchymal stem cells from the Tasmanian devil (Sarcophilus harrisii) express immunomodulatory factors and a tropism toward devil facial tumor cells. Stem Cells and Development, 29 (1), 25-37. doi: 10.1089/scd.2019.0203

Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development

Glass, Nick R., Takasako, Minoru, Er, Pei Xuan, Titmarsh, Drew M., Hidalgo, Alejandro, Wolvetang, Ernst J., Little, Melissa H. and Cooper-White, Justin J. (2020). Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development. Science Advances, 6 (2) eaaw2746, 1-13. doi: 10.1126/sciadv.aaw2746

Inflammatory responses to a pathogenic West Nile virus strain

Huang, Bixing, West, Nic, Vider, Jelena, Zhang, Ping, Griffiths, Rebecca E., Wolvetang, Ernst, Burtonclay, Peter and Warrilow, David (2019). Inflammatory responses to a pathogenic West Nile virus strain. BMC Infectious Diseases, 19 (1) 912, 912. doi: 10.1186/s12879-019-4471-8

Determinants of Zika virus host tropism uncovered by deep mutational scanning

Setoh, Yin Xiang, Amarilla, Alberto A., Peng, Nias Y. G., Griffiths, Rebecca E., Carrera, Julio, Freney, Morgan E., Nakayama, Eri, Ogawa, Shinya, Watterson, Daniel, Modhiran, Naphak, Nanyonga, Faith Elizabeth, Torres, Francisco J., Slonchak, Andrii, Periasamy, Parthiban, Prow, Natalie A., Tang, Bing, Harrison, Jessica, Hobson-Peters, Jody, Cuddihy, Thom, Cooper-White, Justin, Hall, Roy A., Young, Paul R., Mackenzie, Jason M., Wolvetang, Ernst, Bloom, Jesse D., Suhrbier, Andreas and Khromykh, Alexander A. (2019). Determinants of Zika virus host tropism uncovered by deep mutational scanning. Nature Microbiology, 4 (5), 876-887. doi: 10.1038/s41564-019-0399-4

Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiation

Salvador-Palomeque, Carmen, Sanchez-Luque, Francisco J., Fortuna, Patrick R. J., Ewing, Adam D., Wolvetang, Ernst J., Richardson, Sandra R. and Faulkner, Geoffrey J. (2019). Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiation. Molecular and Cellular Biology, 39 (7) e00499-18, 1-19. doi: 10.1128/mcb.00499-18

GRGD-decorated three-dimensional nanoworm hydrogels for culturing human embryonic stem cells

Kessel, Stefanie, Thakar, Nilay, Jia, Zhongfan, Wolvetang, Ernst J. and Monteiro, Michael J. (2019). GRGD-decorated three-dimensional nanoworm hydrogels for culturing human embryonic stem cells. Journal of Polymer Science Part A: Polymer Chemistry, 57 (18), 1956-1963. doi: 10.1002/pola.29342

Platypus induced pluripotent stem cells: the unique pluripotency signature of a monotreme

Whitworth, Deanne J., Limnios, Ioannis J., Gauthier, Marie-Emilie, Weeratunga, Prasanna, Ovchinnikov, Dmitry A., Baillie, Gregory, Grimmond, Sean M., Graves, Jennifer A. Marshall and Wolvetang, Ernst J. (2019). Platypus induced pluripotent stem cells: the unique pluripotency signature of a monotreme. Stem Cells and Development, 28 (3), 151-164. doi: 10.1089/scd.2018.0179

Global proteomic and methylome analysis in human induced pluripotent stem cells reveals overexpression of a human TLR3 affecting proper innate immune response signaling

Requena, J., Alvarez-Palomo, A. B., Codina-Pascual, M., Delgado-Morales, R., Moran, S., Esteller, M., Sal, M., Juan, M., Boronat Barado, A., Consiglio, A., Bogle, O. A., Wolvetang, E., Ovchinnikov, D., Alvarez, I., Jaraquemada, D., Mezquita-Pla, J., Oliva, R. and Edel, M. J. (2019). Global proteomic and methylome analysis in human induced pluripotent stem cells reveals overexpression of a human TLR3 affecting proper innate immune response signaling. Stem Cells, 37 (4), 476-488. doi: 10.1002/stem.2966

Evaluation of variability in human kidney organoids

Phipson, Belinda, Er, Pei X., Combes, Alexander N., Forbes, Thomas A., Howden, Sara E., Zappia, Luke, Yen, Hsan-Jan, Lawlor, Kynan T., Hale, Lorna J., Sun, Jane, Wolvetang, Ernst, Takasato, Minoru, Oshlack, Alicia and Little, Melissa H. (2018). Evaluation of variability in human kidney organoids. Nature Methods, 16 (1), 79-87. doi: 10.1038/s41592-018-0253-2

Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns

Alateeq, Suad, Ovchinnikov, Dmitry, Tracey, Timothy, Whitworth, Deanne, Al-Rubaish, Abdullah, Al-Ali, Amein and Wolvetang, Ernst (2018). Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns. APL Bioengineering, 2 (4) 046103, 046103. doi: 10.1063/1.5048625

Crystal Structures and Cytotoxicity of <i>ent</i>-Kaurane-Type Diterpenoids from Two <i>Aspilia</i> Species

Yaouba, Souaibou, Valkonen, Arto, Coghi, Paolo, Gao, Jiaying, Guantai, Eric M., Derese, Solomon, Wong, Vincent K. W., Erdelyi, Mate and Yenesew, Abiy (2018). Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species. Molecules, 23 (12) ARTN 3199, 3199. doi: 10.3390/molecules23123199

Erratum to: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells (Nature Communications, (2016), 7, 1, (10286), 10.1038/ncomms10286)

Klawitter, Sabine, Fuchs, Nina V., Upton, Kyle R., Muñoz-Lopez, Martin, Shukla, Ruchi, Wang, Jichang, Garcia-Cañadas, Marta, Lopez-Ruiz, Cesar, Gerhardt, Daniel J., Sebe, Attila, Grabundzija, Ivana, Merkert, Sylvia, Gerdes, Patricia, Pulgarin, J. Andres, Bock, Anja, Held, Ulrike, Witthuhn, Anett, Haase, Alexandra, Sarkadi, Balázs, Löwer, Johannes, Wolvetang, Ernst J., Martin, Ulrich, Ivics, Zoltán, Izsvák, Zsuzsanna, Garcia-Perez, Jose L., Faulkner, Geoffrey J. and Schumann, Gerald G. (2018). Erratum to: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells (Nature Communications, (2016), 7, 1, (10286), 10.1038/ncomms10286). Nature Communications, 9 (1) 5398, 5398. doi: 10.1038/s41467-018-07917-0

PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy

Homan, Claire C., Pederson, Stephen, To, Thu-Hien, Tan, Chuan, Piltz, Sandra, Corbett, Mark, Wolvetang, Ernst, Thomas, Paul, Jolly, Lachlan A. and Gecz, Jozef (2018). PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy. Neurobiology of Disease, 116, 106-119. doi: 10.1016/j.nbd.2018.05.004

A simple bioreactor-based method to generate kidney organoids from pluripotent stem cells

Przepiorski, Aneta, Sander, Veronika, Tran, Tracy, Hollywood, Jennifer A., Sorrenson, Brie, Shih, Jen-Hsing, Wolvetang, Ernst J., McMahon, Andrew P., Holm, Teresa M. and Davidson, Alan J. (2018). A simple bioreactor-based method to generate kidney organoids from pluripotent stem cells. Stem Cell Reports, 11 (2), 470-484. doi: 10.1016/j.stemcr.2018.06.018

The impact of APP on Alzheimer-like pathogenesis and gene expression in Down syndrome iPSC-derived neurons

Ovchinnikov, Dmitry A., Korn, Othmar, Virshup, Isaac, Wells, Christine A. and Wolvetang, Ernst J. (2018). The impact of APP on Alzheimer-like pathogenesis and gene expression in Down syndrome iPSC-derived neurons. Stem Cell Reports, 11 (1), 32-42. doi: 10.1016/j.stemcr.2018.05.004

Modelling ischemia-reperfusion injury (IRI) in vitro using metabolically matured induced pluripotent stem cell-derived cardiomyocytes

Hidalgo, Alejandro, Glass, Nick, Ovchinnikov, Dmitry, Yang, Seung-Kwon, Zhang, Xinli, Mazzone, Stuart, Chen, Chen, Wolvetang, Ernst and Cooper-White, Justin (2018). Modelling ischemia-reperfusion injury (IRI) in vitro using metabolically matured induced pluripotent stem cell-derived cardiomyocytes. APL Bioengineering, 2 (2) 026102, 026102. doi: 10.1063/1.5000746

Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseases

Fortuna, Patrick R. J., Bielefeldt-Ohmann, Helle, Ovchinnikov, Dmitry A., Wolvetang, Ernst Jurgen and Whitworth, Deanne Jeanette (2018). Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseases. Stem Cells and Development, 27 (10), 704-715. doi: 10.1089/scd.2017.0106

Expression pattern of the aspartyl-tRNA synthetase DARS in the human brain

Frohlich, Dominik, Suchowerska, Alexandra K., Voss, Carola, He, Ruojie, Wolvetang, Ernst, von Jonquieres, Georg, Simon, Cas, Fath, Thomas, Housley, Gary D. and Klugmann, Matthias (2018). Expression pattern of the aspartyl-tRNA synthetase DARS in the human brain. Frontiers in Molecular Neuroscience, 11 81, 81. doi: 10.3389/fnmol.2018.00081

Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease

Tracey, Timothy J., Steyn, Frederik J., Wolvetang, Ernst J. and Ngo, Shyuan T. (2018). Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease. Frontiers in Molecular Neuroscience, 11 10, 10. doi: 10.3389/fnmol.2018.00010

Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency

Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Whitworth, Deanne J. (2018). Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Stem Cells and Development, 27 (2), 112-122. doi: 10.1089/scd.2017.0224

Pushing the Limits of High Throughput PET-RAFT Polymerization

Ng, Gervase, Yeow, Jonathan, Chapman, Robert, Isahak, Naatasha, Wolvetang, Ernst, Cooper-White, Justin J. and Boyer, Cyrille (2018). Pushing the Limits of High Throughput PET-RAFT Polymerization. Macromolecules, 51 (19), 7600-7607. doi: 10.1021/acs.macromol.8b01600

Targeted, stimuli-responsive delivery of plasmid DNA and miRNAs using a facile self-assembled supramolecular nanoparticle system

Wong, Li-Yen, Xia, Bingzhao, Wolvetang, Ernst and Cooper-White, Justin J. (2017). Targeted, stimuli-responsive delivery of plasmid DNA and miRNAs using a facile self-assembled supramolecular nanoparticle system. Biomacromolecules, 19 (2), 353-363. doi: 10.1021/acs.biomac.7b01462

Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks

Nayler, Sam P., Powell, Joseph E., Vanichkina, Darya P., Korn, Othmar, Wells, Christine A., Kanjhan, Refik, Sun, Jian, Taft, Ryan J., Lavin, Martin F. and Wolvetang, Ernst J. (2017). Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks. Frontiers in Cellular Neuroscience, 11 321, 321. doi: 10.3389/fncel.2017.00321

Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

Bellmaine, Stephanie F., Ovchinnikov, Dmitry A., Manallack, David T., Cuddy, Claire E., Elefanty, Andrew G., Stanley, Edouard G., Wolvetang, Ernst J., Williams, Spencer J. and Pera, Martin (2017). Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells. Elife, 6 e24502. doi: 10.7554/eLife.24502

New concepts on the therapeutic control of complement anaphylatoxin receptors

Hawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J. and Woodruff, Trent M. (2017). New concepts on the therapeutic control of complement anaphylatoxin receptors. Molecular Immunology, 89, 36-43. doi: 10.1016/j.molimm.2017.05.015

FANTOM5 CAGE profiles of human and mouse samples

Noguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter ... Hayashizaki, Yoshihide (2017). FANTOM5 CAGE profiles of human and mouse samples. Scientific Data, 4 (1) 170112, 170112. doi: 10.1038/sdata.2017.112

Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ

Coulthard, Liam G., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Lee, John D., Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Woodruff, Trent M. (2017). Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ. Journal of Neuroscience, 37 (22), 5395-5407. doi: 10.1523/JNEUROSCI.0525-17.2017

Mitochondrial dysfunction and mitophagy in neurodegenerative diseases

Kao, L. P. and Wolvetang, E. J. (2017). Mitochondrial dysfunction and mitophagy in neurodegenerative diseases. Cell and Developmental Biology, 6 doi: 10.4172/2168-9296.1000184

DNA methylation in schizophrenia in different patient-derived cell types

Vitale, Alejandra M., Matigian, Nicholas A., Cristino, Alexandre S., Nones, Katia, Ravishankar, Sugandha, Bellette, Bernadette, Fan, Yongjun, Wood, Stephen A., Wolvetang, Ernst and Mackay-Sim, Alan (2017). DNA methylation in schizophrenia in different patient-derived cell types. Schizophrenia, 3 (1) 6, 1-11. doi: 10.1038/s41537-016-0006-0

The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states

Barry, Guy, Briggs, James A., Hwang, Do Won, Nayler, Sam P., Fortuna, Patrick R. J., Jonkhout, Nicky, Dachet, Fabien, Maag, Jesper L. V., Mestdagh, Pieter, Singh, Erin M., Avesson, Lotta, Kaczorowski, Dominik C., Ozturk, Ezgi, Jones, Nigel C., Vetter, Irina, Arriola-Martinez, Luis, Hu, Jianfei, Franco, Gloria R., Warn, Victoria M., Gong, Andrew, Dinger, Marcel E., Rigo, Frank, Lipovich, Leonard, Morris, Margaret J., O'Brien, Terence J., Lee, Dong Soo, Loeb, Jeffrey A., Blackshaw, Seth, Mattick, John S. and Wolvetang, Ernst J. (2017). The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states. Scientific Reports, 7 (1) 40127, 40127. doi: 10.1038/srep40127

Therapeutic targets and investigated treatments for Ataxia-Telangiectasia

Lavin, Martin F., Yeo, Abrey J., Kijas, Amanda W., Wolvetang, Ernst, Sly, Peter D., Wainwright, Claire and Sinclair, Kate (2016). Therapeutic targets and investigated treatments for Ataxia-Telangiectasia. Expert Opinion on Orphan Drugs, 4 (12), 1263-1276. doi: 10.1080/21678707.2016.1254618

Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage

Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C. Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Journal of Leukocyte Biology, 101 (4), 927-947. doi: 10.1189/jlb.4VMA0716-316R

A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype

Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Human Molecular Genetics, 26 (1), 109-123. doi: 10.1093/hmg/ddw371

Corrigendum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Takasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., Lopes, Susana M. Chuva de Sousa and Little, Melissa H. (2016). Corrigendum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 536 (7615), 238-238. doi: 10.1038/nature17982

AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation

Cullen, Jason K., Murad, Norazian Abdul, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L., Parton, Robert G., Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J., Stocker, Roland and Lavin, Martin F. (2016). AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation. Plos One, 11 (7) e0160162, e0160162. doi: 10.1371/journal.pone.0160162

Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays

Titmarsh, Drew M., Glass, Nick R., Mills, Richard J., Hidalgo, Alejandro, Wolvetang, Ernst J., Porrello, Enzo R., Hudson, James E. and Cooper-White, Justin J. (2016). Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays. Scientific Reports, 6 (1) 24637, 24637. doi: 10.1038/srep24637

AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation

Cullen, Jason K., Murad, Norazian Abdul, Yeo, Abrey, McKenzie, Matthew, Ward, Micheal, Chong, Kok Leong, Schieber, Nicole L., Parton, Robert G., Lim, Yi Chieh, Wolvetang, Ernst, Maghzal, Ghassan J., Stocker, Roland and Lavin, Martin F. (2016). AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation. PLoS One, 11 (2) e0148213, e0148213. doi: 10.1371/journal.pone.0148213

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, Daniel J., et al., Wolvetang, Ernst and Walker, Mark J. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1), 1-222. doi: 10.1080/15548627.2015.1100356

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

Klawitter, Sabine, Fuchs,Nina V., Upton, Kyle R., Munoz-Lopez, Martin, Shukla, Ruchi, Wang, Jichang, Garcia-Canadas, Marta, Lopez-Ruiz, Cesar, Gerhardt, Daniel J., Sebe, Attila, Grabundzija, Ivana, Merkert, Sylvia, Gerdes, Patricia, Pulgarin, J. Andres, Bock, Anja, Held, Ulrike, Witthuhn, Anett, Haase, Alexandra, Sarkadi, Balazs, Lower, Johannes, Wolvetang, Ernst J., Martin, Ulrich, Ivics, Zoltan, Izsvak, Zsuzsanna, Garcia-Perez, Jose L., Faulkner, Geoffrey J. and Schumann, Gerald G. (2016). Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nature Communications, 7 (1) 10286, 1-14. doi: 10.1038/ncomms10286

Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015)

Kliosnky, D., Ernst Wolvetang and Mark J. Walker (2016). Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015). Autophagy, 12 (2), 443-443. doi: 10.1080/15548627.2016.1147886

The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome

Hurst, Laurence D., Ghanbarian, Avazeh T., Forrest, Alistair R. R., Huminiecki, Lukasz, Rehli, Michael, Baillie, J. Kenneth, de Hoon, Michiel J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicolas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S. ... Hayashizaki, Yoshihide (2015). The constrained maximal expression level owing to haploidy shapes gene content on the mammalian X chromosome. PLoS Biology, 13 (12) e1002315, e1002315. doi: 10.1371/journal.pbio.1002315

Generation of footprint-free induced pluripotent stem cells from human fibroblasts using episomal plasmid vectors

Ovchinnikov, Dmitry A., Sun, Jane and Wolvetang, Ernst J. (2015). Generation of footprint-free induced pluripotent stem cells from human fibroblasts using episomal plasmid vectors. Methods in Molecular Biology, 1330, 37-45. doi: 10.1007/978-1-4939-2848-4_4

Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution

Briggs, James A., Wolvetang, Ernst J., Mattick, John S., Rinn, John L. and Barry, Guy (2015). Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution. Neuron, 88 (5), 861-877. doi: 10.1016/j.neuron.2015.09.045

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Takasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., de Sousa Lopes, Susana M. Chuva and Little, Melissa H. (2015). Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 526 (7574), 564-568. doi: 10.1038/nature15695

A protocol for the identification and validation of novel genetic causes of kidney disease

Mallett, Andrew, Patel, Chirag, Maier, Barbara, McGaughran, Julie, Gabbett, Michael, Takasato, Minoru, Cameron, Anne, Trnka, Peter, Alexander, Stephen I., Rangan, Gopala, Tchan, Michel C., Caruana, Georgina, John, George, Quinlan, Cathy, McCarthy, Hugh J., Hyland, Valentine, Hoy, Wedy E., Wolvetang, Ernst, Taft, Ryan, Simons, Cas, Healy H. and Little, Melissa (2015). A protocol for the identification and validation of novel genetic causes of kidney disease. BMC Nephrology, 16 (152) 148, 152. doi: 10.1186/s12882-015-0148-8

Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development

Hasegawa, Yu., Taylor, Deanne., Ovchinnikov, Dmitry A., Wolvetang, Ernst J., de Torrente, Laurence. and Mar, Jessica C. (2015). Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development. PLoS Genetics, 11 (8) e1005428, e1005428. doi: 10.1371/journal.pgen.1005428

A new model to study neurodegeneration in ataxia oculomotor apraxia type 2

Becherel, Olivier J., Sun, Jane, Yeo, Abrey J., Nayler, Sam, Fogel, Brent L., Gao, Fuying, Coppola, Giovanni, Criscuolo, Chiara, De Michele, Giuseppe, Wolvetang, Ernst and Lavin, Martin F. (2015). A new model to study neurodegeneration in ataxia oculomotor apraxia type 2. Human Molecular Genetics, 24 (20), 5759-5774. doi: 10.1093/hmg/ddv296

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Arner, Erik, Daub, Carsten O., Vitting-Seerup, Kristoffer, Andersson, Robin, Lilje, Berit, Drabløs, Finn, Lennartsson, Andreas, Rönnerblad, Michelle, Hrydziuszko, Olga, Vitezic, Morana, Freeman, Tom C., Alhendi, Ahmad M. N., Arner, Peter, Axton, Richard, Baillie, J. Kenneth, Beckhouse, Anthony, Bodega, Beatrice, Briggs, James, Brombacher, Frank, Davis, Margaret, Detmar, Michael, Ehrlund, Anna, Endoh, Mitsuhiro, Eslami, Afsaneh, Fagiolini, Michela, Fairbairn, Lynsey, Faulkner, Geoffrey J., Ferrai, Carmelo, Fisher, Malcolm E. ... Hayashizaki, Yoshihide (2015). Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science, 347 (6225), 1010-1014. doi: 10.1126/science.1259418

High-throughput, deterministic single cell trapping and long-term clonal cell culture in microfluidic devices

Chen, Huaying, Sun, Jane, Wolvetang, Ernst and Cooper-White, Justin (2015). High-throughput, deterministic single cell trapping and long-term clonal cell culture in microfluidic devices. Lab on a Chip, 15 (4), 1072-1083. doi: 10.1039/C4LC01176G

TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.

Thakar, Nilay Y., Ovchinnikov, Dmitry A., Hastie, Marcus L., Kobe, Bostjan, Gorman, Jeffrey J. and Wolvetang, Ernst J. (2015). TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.. Molecular Biology of the Cell, 26 (5), 993-1006. doi: 10.1091/mbc.E14-08-1290

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1

Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754

Advances in reprogramming to pluripotency

Alateeq, Suad, Fortuna, Patrick R. J. and Wolvetang, Ernst (2015). Advances in reprogramming to pluripotency. Current Stem Cell Research and Therapy, 10 (3), 193-207. doi: 10.2174/1574888X10666150220154820

Expression of Histocompatibility 2 Blastocyst (H2-Bl) in embryonic stem cells inhibits CD8+ T-cell activation but is not sufficient to facilitate graft tolerance

Dingwall, Steven, Brooks, Andrew, Apte, Simon H., Waters, Mike, Lavin, Martin F. and Wolvetang, Ernst J. (2015). Expression of Histocompatibility 2 Blastocyst (H2-Bl) in embryonic stem cells inhibits CD8+ T-cell activation but is not sufficient to facilitate graft tolerance. Journal of Stem Cell Research and Therapy, 5 (12) 1000320, 1-8. doi: 10.4172/2157-7633.1000320

RELB alters proliferation of human pluripotent stem cells via IMP3- and LIN28-mediated modulation of the expression of IGF2 and other cell-cycle regulators

Thakar, Nilay Yogeshkumar, Ovchinnikov, Dmitry Alexander, Hastie, Marcus Lachlan, Gorman, Jeffrey and Wolvetang, Ernst Jurgen (2015). RELB alters proliferation of human pluripotent stem cells via IMP3- and LIN28-mediated modulation of the expression of IGF2 and other cell-cycle regulators. Stem Cells and Development, 24 (16), 1888-1900. doi: 10.1089/scd.2014.0587

The statistical geometry of transcriptome divergence in cell-type evolution and cancer

Liang, Cong, The FANTOM Consortium, Forrest, Alistair R. R., Wagner, Guenter P., Kenna, Tony, Beckhouse, Anthony, Blumenthal, Antje, Briggs, James, Hitchens, Kelly, Ovchinnikov, Dmitry, Vijayan, Dipti, Wells, Christine and Wolvetang, Ernst (2015). The statistical geometry of transcriptome divergence in cell-type evolution and cancer. Nature Communications, 6 (1) 6066. doi: 10.1038/ncomms7066

Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2

Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014). Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 (12), 3278-3284. doi: 10.1002/stem.1801

Opportunities and limitations of modelling Alzheimer’s disease with induced pluripotent stem cells

Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2014). Opportunities and limitations of modelling Alzheimer’s disease with induced pluripotent stem cells. Journal of Clinical Medicine, 3 (4), 1357-1372. doi: 10.3390/jcm3041357

Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency.

Alamein, Mohammad A., Wolvetang, Ernst J., Ovchinnikov, Dmitry A., Stephens, Sebastien, Sanders, Katherine and Warnke, Patrick H. (2014). Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency.. Journal of Tissue Engineering and Regenerative Medicine, 9 (9), 1078-1083. doi: 10.1002/term.1960

Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrations

Turner, Jennifer, Quek,Lake-Ee, Titmarsh, Drew, Kromer, Jens O., Kao, Li-Pin, Nielsen, Lars, Wolvetang, Ernst and Cooper-White, Justin (2014). Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrations. PLoS One, 9 (11) e112757, e112757.1-e112757.13. doi: 10.1371/journal.pone.0112757

Specific mesothelial signature marks the heterogeneity of mesenchymal stem cells from high-grade serous ovarian cancer

Verardo, Roberto, Piazza, Silvano, Klaric, Enio, Ciani, Yari, Bussadori, Giulio, Marzinotto, Stefania, Mariuzzi, Laura, Cesselli, Daniela, Beltrami, Antonio P., Mano, Miguel, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Beltrami, Carlo A., The Fantom Consortium, Schneider, Claudio, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Wolvetang, Ernst, Hitchens, Kelly, Kenna, Tony, Blumenthal, Antje, Briggs, James, Ovchinnikov, Dmitry, Fearnley, Liam ... Nielsen, Lars (2014). Specific mesothelial signature marks the heterogeneity of mesenchymal stem cells from high-grade serous ovarian cancer. Stem Cells (Durham), 32 (11), 2998-3011. doi: 10.1002/stem.1791

Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporter

Ovchinnikov, Dmitry A.,, Hidalgo, Alejandro, Yang, Seung-Kwon, Zhang, Xinli, Hudson, James, Mazzone, Stuart B., Chen, Chen, Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporter. Stem Cells and Development, 24 (1), 11-20. doi: 10.1089/scd.2014.0195

Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro

Ovchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R. J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro. Stem Cell Research, 13 (2), 251-261. doi: 10.1016/j.scr.2014.05.006

Gene expression variability as a unifying element of the pluripotency network

Mason, Elizabeth, Mar, Jessica C., Laslett, Andrew, Pera, Martin F., Quackenbush, John, Wolvetang, Ernst and Wells C. (2014). Gene expression variability as a unifying element of the pluripotency network. Stem Cell Reports, 3 (2), 365-377. doi: 10.1016/j.stemcr.2014.06.008

Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway

Whitworth, Deanne J., Frith, Jessica E, Frith, Thomas J. R., Ovchinnikov, Dmitry A., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFbeta/activin signaling pathway. Stem Cells and Development, Online Ahead of Print (24), 3021-3033. doi: 10.1089/scd.2013.0634

CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes

Hasegawa, Yuki, Tang, Dave, Takahashi, Naoko, Hayashizaki, Yoshihide, Forrest, Alistair R. R., the FANTOM consortium, Suzuki, Harukazu, Blumenthal, Antje, Kenna, Tony, Briggs, James, Beckhouse, Anthony G., Hitchens, Kelly J., Ovchinnikov, Dmitry A., Vijayan, Dipti, Wells, Christine A. and Wolvetang, Ernst (2014). CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes. Scientific Reports, 4 (Art No: 5228) 5228, 277-279. doi: 10.1038/srep05228

Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance

Fort, Alexandre, Hashimoto, Kosuke, Yamada, Daisuke, Salimullah, Md, Keya, Chaman A., Saxena, Alka, Bonetti, Alessandro, Voineagu, Irina, Bertin, Nicolas, Kratz, Anton, Noro, Yukihiko, Wong, Chee-Hong, de Hoon, Michiel, Andersson, Robin, Sandelin, Albin, Suzuki, Harukazu, Wei, Chia-Lin, Koseki, Haruhiko, Hasegawa, Yuki, Forrest, Alistair R. R., Carninci, Piero, FANTOM Consortium, Beckhouse, Anthony, Blumenthal, Antje, Briggs, James, Hitchens, Kelly, Kenna, Tony, Ovchinnikov, Dmitry, Vijayan, Dipti ... Wolvetang, Ernst (2014). Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance. Nature Genetics, 46 (6), 558-566. doi: 10.1038/ng.2965

RECLU: a pipeline to discover reproducible transcriptional start sites and their alternative regulation using capped analysis of gene expression (CAGE)

Ohmiya, Hiroko, Vitezic, Morana, Frith, Martin C., Itoh, Masayoshi, Carninci, Piero, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Lassmann, Timo, FANTOM Consortium, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Mason, Elizabeth, Wolvetang, Ernst, Hitchens, Kelly, Le Cao, Kim-Anh, Nielsen, Lars, Fearnley, Liam, Kenna, Tony and Blumenthal, Antje (2014). RECLU: a pipeline to discover reproducible transcriptional start sites and their alternative regulation using capped analysis of gene expression (CAGE). BMC Genomics, 15 (1) 269. doi: 10.1186/1471-2164-15-269

Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation

Rönnerblad, Michelle, Andersson, Robin, Olofsson, Tor, Douagi, Iyadh, Karimi, Mohsen, Lehmann, Sören, Hoof, Ilka, de Hoon, Michiel, Itoh, Masayoshi, Nagao-Sato, Sayaka, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Sandelin, Albin, Ekwall, Karl, Amer, Erik, Lennartsson, Andreas, for the FANTOM consortium, Wells, Christine, Wolvetang, Ernst, Blumenthal, Antje, Kenna, Tony, Hitchens, Kelly, Ovchinnikov, Dmitry, Fearnley, Liam, Le Cao, Kim-Anh, Mason, Elizabeth ... Vijayan, Dipti (2014). Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation. Blood, 123 (17), e79-e89. doi: 10.1182/blood-2013-02-482893

High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis

Prasad, Punit, Rönnerblad, Michelle, Arner, Erik, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Daub, Carsten O., Forrest, Alistair R. R., Lennartsson, Andreas, Ekwall, Karl, for the FANTOM Consortium, Wells, Christine, Wolvetang, Ernst, Blumenthal, Antje and Kenna, Tony (2014). High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis. Blood, 123 (17), e46-e57. doi: 10.1182/blood-2013-02-483537

Redefinition of the human mast cell transcriptome by deep-CAGE sequencing

Motakis, Efthymios, Guhl, Sven, Ishizu, Yuri, Itoh, Masayoshi, Kawaji, Hideya, de Hoon, Michiel, Lassman, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Zuberbier, Torsten, Forrest, Alistair R. R., Babina, Magda, for The FANTOM Consortium, Wells, Christine, Wolvetang, Ernst, Beckhouse, Anthony, Fearnley, Liam, Hitchens, Kelly, Kenna, Tony, Le Cao, Kim-Anh, Mason, Elizabeth, Nielsen, Lars, Vijayan, Dipti, Blumenthal, Antje, Ovchinnikov, Dmitry and Briggs, James (2014). Redefinition of the human mast cell transcriptome by deep-CAGE sequencing. Blood, 123 (17), 58-67. doi: 10.1182/blood-2013-02-483792

The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations

Schmidl, Christian, Hansmann, Leo, Lassmann, Timo, Balwierz, Piotr J., Kawaji, Hideya, Itoh, Masayoshi, Kawai, Jun, Nagao-Sato, Sayaka, Suzuki, Harukazu, Andreesen, Reinhard, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Carninci, Piero, Hoffmann, Petra, Edinger, Matthias, Rehli, Michael, for the FANTOM consortium, Wells, Christine and Wolvetang, Ernst (2014). The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood, 123 (17), e68-e78. doi: 10.1182/blood-2013-02-486944

Transcription and enhancer profiling in human monocyte subsets

Schmidl, Christian, Renner, Kathrin, Peter, Katrin, Eder, Ruediger, Lassmann, Timo, Balwierz, Piotr J., Itoh, Masayohshi, Nagao-Sato, Sayaka, Kawaji, Hideya, Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Andreesen, Reinhard, Hume, David A., Hoffmann, Petra, Forrest, Alistair R. R., Kreutz, Marina P., Edinger, Matthias, Rehli, Michael, for the FANTOM consortium, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Mason, Elizabeth, Wolvetang, Ernst, Hitchens, Kelly, Le Cao, Kim-Anh, Nielsen, Lars, Fearnley, Liam and Kenna, Tony (2014). Transcription and enhancer profiling in human monocyte subsets. Blood, 123 (17), e90-e99. doi: 10.1182/blood-2013-02-484188

Interactive visualization and analysis of large-scale sequencing datasets using ZENBU

Severin, Jessica, Lizio, Marina, Harshbarger, Jayson, Kawaji, Hideya, Daub, Carsten O., Hayashizaki, Yoshihide, Bertin, Nicolas, Forrest, Alistair R. R., FANTOM Consortium, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Mason, Elizabeth, Wolvetang, Ernst, Hitchens, Kelly, Le Cao, Kim-Anh, Nielsen, Lars, Fearnley, Liam and Kenna, Tony (2014). Interactive visualization and analysis of large-scale sequencing datasets using ZENBU. Nature Biotechnology, 32 (3), 217-219. doi: 10.1038/nbt.2840

Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts

Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2014). Generation and characterization of leukemia inhibitory factor-dependent equine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, Fast Track Articles (13), 1-9. doi: 10.1089/scd.2013.0461

A promoter-level mammalian expression atlas

Forest, Alistair R. R., Kawaji, Hideya, Rehli, Michael, Baillie, J. Kenneth, De Hoon, Michael J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicholas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Altschuler, Intikhab ... Hayashizaki, Yoshihide (2014). A promoter-level mammalian expression atlas. Nature, 507 (7493), 462-470. doi: 10.1038/nature13182

A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

Hurst, Laurence D., Sachenkova, Oxana, Daub, Carsten, Forrest, Alistair R. R., the FANTOM consortium, Huminiecki, Lukasz, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Wolvetang, Ernst, Hitchens, Kelly, Kenna, Tony, Blumenthal, Antje, Briggs, James, Ovchinnikov, Dmitry, Fearnley, Liam, Le Cao, Kim-Anh, Mason, Elizabeth and Nielsen, Lars (2014). A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators. Genome Biology, 15 (7) 413. doi: 10.1186/s13059-014-0413-3

A transient disruption of fibroblastic transcriptional regulatory network facilitates trans-differentiation

Tomaru, Yasuhiro, Hasegawa, Ryota, Suzuki, Takahiro, Sato, Taiji, Kubosaki, Atsutaka, Suzuki, Masanori, Kawaji, Hideya, Forrest, Alistair R. R., Hayashizaki, Yoshihide, FANTOM Consortium, Shin, Jay W., Suzuki, Harukazu, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Wolvetang, Ernst, Hitchens, Kelly, Fearnley, Liam, Kenna, Tony, Blumenthal, Antje, Briggs, James, Ovchinnikov, Dmitry, Le Cao, Kim-Anh, Mason, Elizabeth and Nielsen, Lars (2014). A transient disruption of fibroblastic transcriptional regulatory network facilitates trans-differentiation. Nucleic Acids Research, 42 (14), 8905-8913. doi: 10.1093/nar/gku567

Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules

Grison, Alice, Zucchelli, Silvia, Urzi, Alice, Zamparo, Ilaria, Lazarevic, Dejan, Pascarella, Giovanni, Roncaglia, Paola, Giorgetti, Alejandro, Garcia-Esparcia, Paula, Vlachouli, Christina, Simone, Roberto, Persichetti, Francesca, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Carloni, Paolo, Ferrer, Isidro, Lodovichi, Claudia, Plessy, Charles, the FANTOM Consortium, Carninci, Piero, Gustincich, Stefano, Beckhouse, Anthony, Briggs, James, Hitchens, Kelly, Kenna, Tony, Ovchinnikov, Dmitry, Vijayan, Dipti, Wells, Christine, Wolvetang, Ernst ... Nielsen, Lars (2014). Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules. BMC Genomics, 15 (1) 729. doi: 10.1186/1471-2164-15-729

Identification of Unsafe Human Induced Pluripotent Stem Cell Lines Using a Robust Surrogate Assay for Pluripotency

Polanco, Juan Carlos, Ho, Mirabelle S. H., Wang, Bei, Zhou, Qi, Wolvetang, Ernst, Mason, Elizabeth, Wells, Christine A., Kolle, Gabriel, Grimmond, Sean M., Bertoncello, Ivan, O'Brien, Carmel and Laslett, Andrew L. (2013). Identification of Unsafe Human Induced Pluripotent Stem Cell Lines Using a Robust Surrogate Assay for Pluripotency. Stem Cells, 31 (8), 1498-1510. doi: 10.1002/stem.1425

Full factorial screening of human embryonic stem cell maintenance with multiplexed microbioreactor arrays

Titmarsh, Drew M., Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Cooper-White, Justin J. (2013). Full factorial screening of human embryonic stem cell maintenance with multiplexed microbioreactor arrays. Biotechnology Journal, 8 (7), 822-834. doi: 10.1002/biot.201200375

Autophagy in stem cells

Guan, Jun-Lin, Simon, Anna Katharina, Prescott, Mark, Menendez, Javier A., Liu, Fei, Wang, Fen, Wang, Chenran, Wolvetang, Ernst, Vazquez-Martin, Alejandro and Zhang, Jue (2013). Autophagy in stem cells. Autophagy, 9 (6), 830-849. doi: 10.4161/auto.24132

Concise review: new paradigms for down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease

Briggs, James A., Mason, Elizabeth A., Ovchinnikov, Dmitry A., Wells, Christine A. and Wolvetang, Ernst J. (2013). Concise review: new paradigms for down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Translational Medicine, 2 (3), 175-184. doi: 10.5966/sctm.2012-0117

Integration-free induced pluripotent stem cells model genetic and neural developmental features of Down Syndrome etiology

Briggs, James A., Sun, Jane, Shepherd, Jill, Ovchinnikov, Dmitry A., Chung, Tung-Liang, Nayler, Sam P., Kao, Li-Pin, Morrow, Carl A., Thakar, Nilay Y., Soo, Set-Yen, Peura, Teija, Grimmond, Sean and Wolvetang, Ernst J. (2013). Integration-free induced pluripotent stem cells model genetic and neural developmental features of Down Syndrome etiology. Stem Cells, 31 (3), 467-478. doi: 10.1002/stem.1297

Arrayed cellular environments for stem cells and regenerative medicine

Titmarsh, Drew M., Chen, Huaying, Wolvetang, Ernst J. and Cooper-White, Justin J. (2013). Arrayed cellular environments for stem cells and regenerative medicine. Biotechnology Journal, 8 (2), 167-179. doi: 10.1002/biot.201200149

Tailorable cell culture platforms from enzymatically cross-linked multifunctional poly(ethylene glycol)-based hydrogels

Menzies, Donna J., Cameron, Andrew, Munro, Trent, Wolvetang, Ernst, Grondahl, Lisbeth and Cooper-White, Justin J. (2013). Tailorable cell culture platforms from enzymatically cross-linked multifunctional poly(ethylene glycol)-based hydrogels. Biomacromolecules, 14 (2), 413-423. doi: 10.1021/bm301652q

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

Barry, Guy, Briggs, J. A., Vanichkina, D. P., Poth, E. M., Beveridge, N. J., Vikram Ratnu, Nayler, S. P., Nones, K., Hu, J., Timothy Bredy, Nakagawa, S., Rigo, F., Taft, R. J., Cairns, M. J., Blackshaw, S., Wolvetang, E. J. and Mattick, J. S. (2013). The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Molecular Psychiatry, 19 (4), 486-494. doi: 10.1038/mp.2013.45

Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?

Filippich, Cheryl, Wolvetang, Ernst J. and Mowry, Bryan J. (2013). Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?. Schizophrenia Bulletin, 39 (5), 948-954. doi: 10.1093/schbul/sbt103

Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation

Titmarsh, Drew M., Hudson, James E., Hidalgo, Alejandro, Elefanty, Andrew G., Stanley, Edouard G., Wolvetang, Ernst J. and Cooper-White, Justin J. (2012). Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation. PLoS One, 7 (12) e52405, e52405.1-e52405.12. doi: 10.1371/journal.pone.0052405

Tumor-suppressor gene promoter hypermethylation in saliva of head and neck cancer patients

Ovchinnikov, Dmitry A., Cooper, Matthew A., Pandit, Pratibala, Coman, William B., Cooper-White, Justin J., Keith, Patricia, Wolvetang, Ernst J., Slowey, Paul D. and Punyadeera, Chamindie (2012). Tumor-suppressor gene promoter hypermethylation in saliva of head and neck cancer patients. Translational Oncology, 5 (5), 321-326. doi: 10.1593/tlo.12232

Differential mesengenic potential and expression of stem cell-fate modulators in mesenchymal stromal cells from human-term placenta and bone marrow

Jaramillo-Ferrada, Pamela A., Wolvetang, Ernst J. and Cooper-White, Justin J. (2012). Differential mesengenic potential and expression of stem cell-fate modulators in mesenchymal stromal cells from human-term placenta and bone marrow. Journal of Cellular Physiology, 227 (9), 3234-3242. doi: 10.1002/jcp.24014

Variability in the Generation of Induced Pluripotent Stem Cells: Importance for Disease Modeling

Vitale, Alejandra M., Matigian, Nicholas A., Ravishankar, Sugandha, Bellette, Bernadette, Wood, Stephen A., Wolvetang, Ernst J. and Mackay-Sim, Alan (2012). Variability in the Generation of Induced Pluripotent Stem Cells: Importance for Disease Modeling. Stem Cells Translational Medicine, 1 (9), 641-650. doi: 10.5966/sctm.2012-0043

Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts

Whitworth, Deanne J., Ovchinnikov, Dmitry A. and Wolvetang, Ernst J. (2012). Generation and characterization of LIF-dependent canine induced pluripotent stem cells from adult dermal fibroblasts. Stem Cells and Development, 21 (12), 2288-2297. doi: 10.1089/scd.2011.0608

Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular Phenotype

Nayler, Sam, Gatei, Magtouf, Kozlov, Sergei, Gatti, Richard, Mar, Jessica C., Wells, Christine A., Lavin, Martin and Wolvetang, Ernst (2012). Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular Phenotype. Stem Cells Translational Medicine, 1 (7), 523-535. doi: 10.5966/sctm.2012-0024

Generation of a human embryonic stem cell line stably expressing high levels of the fluorescent protein mCherry

Ovchinnikov, Dmitry A., Turner, Jennifer P., Titmarsh, Drew M., Thakar, Nilay Y., Sin, Dong Choon, Cooper-White, Justin J. and Wolvetang, Ernst J. (2012). Generation of a human embryonic stem cell line stably expressing high levels of the fluorescent protein mCherry. World Journal of Stem Cells, 4 (7), 71-9. doi: 10.4252/wjsc.v4.i7.71

Primitive cardiac cells from human embryonic stem cells

Hudson, James, Titmarsh, Drew, Hidalgo, Alejandro, Wolvetang, Ernst and Cooper-White, Justin (2012). Primitive cardiac cells from human embryonic stem cells. Stem Cells and Development, 21 (9), 1513-1523. doi: 10.1089/scd.2011.0254

The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts

Kao, Li-Pin, Ovchinnikov, Dmitry and Wolvetang, Ernst (2012). The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts. Toxicology and Applied Pharmacology, 261 (1), 42-49. doi: 10.1016/j.taap.2012.03.009

Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells

Chen, Yen Shun, Pelekanos, Rebecca A., Ellis, Rebecca L., Horne, Rachel, Wolvetang, Ernst J. and Fisk, Nicholas M. (2012). Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells. Stem Cells Translational Medicine, 1 (2), 83-95. doi: 10.5966/sctm.2011-0022

Fabrication of nanopatterned, porous microspheres using a glass capillary microfluidic device

Sin, Dongchoon, Fitzpatrick, Jane, Luckman, Paul, Wolvetang, Ernst J. and Cooper-White, Justin J. (2012). Fabrication of nanopatterned, porous microspheres using a glass capillary microfluidic device. Soft Matter, 8 (41), 10712-10718. doi: 10.1039/c2sm25950h

Optimization of flowrate for expansion of human embryonic stem cells in perfusion microbioreactors

Titmarsh, Drew, Hidalgo, Alejandro, Turner, Jennifer, Wolvetang, Ernst and Cooper-White, Justin (2011). Optimization of flowrate for expansion of human embryonic stem cells in perfusion microbioreactors. Biotechnology and Bioengineering, 108 (12), 2894-2904. doi: 10.1002/bit.23260

Autophagy in human embryonic stem cells

Tra, Thien, Gong, Lan, Kao, Lin-Pin, Li, Xue-Lei, Grandela, Catarina, Devenish, Rodney J., Wolvetang, Eernst and Prescott, Mark (2011). Autophagy in human embryonic stem cells. PLoS One, 6 (11) e27485, e27485.1-e27485.7. doi: 10.1371/journal.pone.0027485

Development of myocardial constructs using modulus-matched acrylated polypropylene glycol triol substrate and different nonmyocyte cell populations

Hudson, James E., Brooke, Gary, Blair, Chris, Wolvetang, Ernst and Cooper-White, Justin John (2011). Development of myocardial constructs using modulus-matched acrylated polypropylene glycol triol substrate and different nonmyocyte cell populations. Tissue Engineering Part A: Tissue Engineering, 17 (17-18), 2279-2289. doi: 10.1089/ten.tea.2010.0743

A defined medium and substrate for expansion of human mesenchymal stromal cell progenitors that enriches for osteo- and chondrogenic precursors

Hudson, James E., Mills, Richard J., Frith, Jessica E., Brooke, Gary, Jaramillo-Ferrada, Pamela, Wolvetang, Ernst J. and Cooper-White, Justin J. (2011). A defined medium and substrate for expansion of human mesenchymal stromal cell progenitors that enriches for osteo- and chondrogenic precursors. Stem Cells and Development, 20 (1), 77-87. doi: 10.1089/scd.2009.0497

Genetic and epigenetic instability of human pluripotent stem cells

Chung, Tung-Liang, Thaker, Nilay Y. and Wolvetang, Ernst J. (2011). Genetic and epigenetic instability of human pluripotent stem cells. The Open Stem Cell Journal, 3, 52-61. doi: 10.2174/1876893801103010052

Induced pluripotent cells: a new technology to study human diseases

Vitale, Alejandra M., Wolvetang, Ernst and Mackay-Sim, Alan (2011). Induced pluripotent cells: a new technology to study human diseases. The International Journal of Biochemistry and Cell Biology, In press (6), 843-846. doi: 10.1016/j.biocel.2011.03.013

A synthetic elastomer based on acrylated polypropylene glycol triol with tunable modulus for tissue engineering applications

Hudson, James E., Frith, Jessica E., Donose, Bogdan C., Rondeau, Elisabeth, Mills, Richard J., Wolvetang, Ernst J., Brooke, Gary P. and Cooper-White, Justin J. (2010). A synthetic elastomer based on acrylated polypropylene glycol triol with tunable modulus for tissue engineering applications. Biomaterials, 31 (31), 7937-7947. doi: 10.1016/j.biomaterials.2010.07.007

Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media

Prowse, Andrew B. J., Doran, Michael R., Cooper-White, Justin J., Chong, Fenny, Munro, Trent P., Fitzpatrick, Jane, Chung, Tung-Liang, Haylock, David N., Gray, Peter P. and Wolvetang, Ernst J. (2010). Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media. Biomaterials, 31 (32), 8281-8288. doi: 10.1016/j.biomaterials.2010.07.037

Ascorbate promotes epigenetic activation of CD30 in human embryonic stem cells

Chung, Tung-Liang, Turner, Jennifer P., Thaker, Nilay Y., Kolle, Gabriel, Cooper-White, Justin J., Grimmond, Sean M., Pera, Martin F. and Wolvetang, Ernst J. (2010). Ascorbate promotes epigenetic activation of CD30 in human embryonic stem cells. Stem Cells, 28 (10), 1782-1793. doi: 10.1002/stem.500

Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells

Chung, TL, Brena, RM, Kolle, G, Grimmond, SM, Berman, BP, Laird, PW, Pera, MF and Wolvetang, EJ (2010). Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells, 28 (10), 1848-1855. doi: 10.1002/stem.493

Defined high protein content surfaces for stem cell culture

Doran, Michael R., Frith, Jessica E., Prowse, Andrew B. J., Fitzpatrick, Jane, Wolvetang, Ernst J., Munro, Trent P., Gray, Peter P. and Cooper-White, Justin J. (2010). Defined high protein content surfaces for stem cell culture. Biomaterials, 31 (19), 5137-5142. doi: 10.1016/j.biomaterials.2010.03.015

Multiplexed Staining of Live Human Embryonic Stem Cells for Flow Cytometric Analysis of Pluripotency Markers

Prowse, ABJ, Wilson, J, Osborne, GW, Gray, PP and Wolvetang, EJ (2009). Multiplexed Staining of Live Human Embryonic Stem Cells for Flow Cytometric Analysis of Pluripotency Markers. Stem Cells and Development, 18 (8), 1135-1139. doi: 10.1089/scd.2009.0080

BMP-11 and Myostatin Support Undifferentiated Growth of Human Embryonic Stem Cells in Feeder-Free Cultures

Hannan, N.R.F., Jamshidi, P., Pera, M.F. and Wolvetang, E.J. (2009). BMP-11 and Myostatin Support Undifferentiated Growth of Human Embryonic Stem Cells in Feeder-Free Cultures. Cloning and Stem Cells, 11 (3), 427-435. doi: 10.1089/clo.2009.0024

Corrigendum to "p53 is required for etoposide-induced apoptosis of human embryonic stem cells" [Stem Cell Research 1 (2008) 116-128]

Grandela, C., Pera, M. F., Grimmond, S. M., Kolle, G. and Wolvetang, E. J. (2009). Corrigendum to "p53 is required for etoposide-induced apoptosis of human embryonic stem cells" [Stem Cell Research 1 (2008) 116-128]. Stem Cell Research, 3 (2-3), 179-179. doi: 10.1016/j.scr.2008.12.001

A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps

Prowse, ABJ, Wolvetang, EJ and Gray, PP (2009). A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps. Biotechniques, 47 (1), 599-606. doi: 10.2144/000113151

Adipocyte differentiation in human embryonic stem cells transduced with Oct4 shRNA lentivirus

Hannan, Nicholas R.F. and Wolvetang, Ernst J. (2009). Adipocyte differentiation in human embryonic stem cells transduced with Oct4 shRNA lentivirus. Stem Cells Development, 18 (4), 653-660. doi: 10.1089/scd.2008.0160

Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines

Cullinane, Meabh, Gong, Lan, Lazar-Adler, Natalie, Tra, Thien, Wolvetang, Ernst, Prescott, Mark, Boyce, John D., Devenish, Rodney J. and Adler, Ben (2008). Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines. Autophagy, 4 (6), 744-753. doi: 10.4161/auto.6246

p53 is required for etoposide-induced apoptosis of human embryonic stem cells

Grandela, C., Pera, M. F. and Wolvetang, E. J. (2008). p53 is required for etoposide-induced apoptosis of human embryonic stem cells. Stem Cell Research, 1 (2), 116-128. doi: 10.1016/j.scr.2007.10.003

Gap junction mediated transport of shRNA between human embryonic stem cells

Wolvetang, Ernst J., Pera, Martin F. and Zuckerman, Kenneth S. (2007). Gap junction mediated transport of shRNA between human embryonic stem cells. Biochemical and biophysical research communications, 363 (3), 610-615. doi: 10.1016/j.bbrc.2007.09.035

hESC Adaptation, Selection and Stability

Grandela, C. and Wolvetang, E. (2007). hESC Adaptation, Selection and Stability. Stem Cell Reviews and Reports, 3 (3), 183-191. doi: 10.1007/s12015-007-0008-4

CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells

Herszfeld, Daniella, Wolvetang, Ernst, Langton-Bunker, Emma, Chung, Tung-Liang, Filipczyk, Adam A,, Houssami, Souheir, Pegah Jamshid, Koh, Karen, Laslett, Andrew L., Anna Michalska, Nguyen, Linh, Reubinoff, Benjamin E., Tellis, Irene, Auerbach, Jonathan M., Ording, Carol J., Looijenga, Leendert H. J. and Pera, Martin F. (2006). CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nature Biotechnology, 24 (3), 351-357. doi: 10.1038/nbt1197

Mitochondrial dysfunction in mouse oocytes results in preimplantation embryo arrest in vitro. (vol 71, pg 1936, 2004)

Thouas, GA, Trounson, AO, Wolvetang, EJ and Jones, GM (2005). Mitochondrial dysfunction in mouse oocytes results in preimplantation embryo arrest in vitro. (vol 71, pg 1936, 2004). Biology of Reproduction, 73 (6), 1312-1312. doi: 10.1095/biolreprod.105.048561

Essential Roles of Sphingosine-1-Phosphate and Platelet-Derived Growth Factor in the Maintenance of Human Embryonic Stem Cells

Pebay, Alice, Wong, Raymond C. B., Pitson, Stuart M., Wolvetang, Ernst J., Peh, Gary S.-L., Fykilipcz, Adam, Koh, Karen L. L., Tellis, Irene, Nguyen, Linh T.V. and Pera, Martin F. (2005). Essential Roles of Sphingosine-1-Phosphate and Platelet-Derived Growth Factor in the Maintenance of Human Embryonic Stem Cells. Stem Cells, 23 (10), 1541-1548. doi: 10.1634/stemcells.2004-0338

ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons

Helguera, Pablo, Pelsman, Alejandra, Pigino, Gustavo, Wolvetang, Ernst, Head, Elizabeth and Busciglio, Jorge (2005). ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. Journal of Neuroscience, 25 (9), 2295-2303. doi: 10.1523/JNEUROSCI.5107-04.2005

Mitochondrial Dysfunction in Mouse Oocytes Results in Preimplantation Embryo Arrest in Vitro full access

Thouas, George, A., Trounson, Alan O., Wolvetang, Ernst J. and Jones, Gayle M. (2004). Mitochondrial Dysfunction in Mouse Oocytes Results in Preimplantation Embryo Arrest in Vitro full access. Biology of Reproduction, 71 (6), 1936-1942. doi: 10.1095/biolreprod.104.033589

The chromosome 21 transcription factor ETS2 transactivates the β-APP promoter: Implications for Down syndrome

Wolvetang, E. W., Bradfield, O. M., Tymms, M., Zavarsek, S., Hatzistavrou, T., Kola, I. and Hertzog, P. J. (2003). The chromosome 21 transcription factor ETS2 transactivates the β-APP promoter: Implications for Down syndrome. Biochimica et biophysica acta (BBA). Gene structure and expression, 1628 (2), 105-110. doi: 10.1016/S0167-4781(03)00121-0

Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5

Ohtani, Naoko, Brennan, Paul, Gaubatz, Stefan, Sanij, Elaine, Hertzog, Paul, Wolvetang, Ernst, Ghysdael, Jacques, Rowe, Martin and Hara, Eiji (2003). Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5. Journal of Cell Biology, 162 (2), 173-183. doi: 10.1083/jcb.200302085

Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis

Leech, Michelle, Lacey, Derek, Santos, leilani, Hutchinson, Paul, Wolvetang, Ernst, David, John R., Bucala, Richard and Morand, Eric F. (2003). Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis. Arthritis & Rheumatism, 48 (7), 1881-1889. doi: 10.1002/art.11165

Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein

Sanij, Elaine, Scott, Bernadette, Wilson, Trevor, Xu, Dakang, Hertzog, Paul and Wolvetang, Ernst (2003). Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein. Immunology Letters, 86 (1), 63-70. doi: 10.1016/S0165-2478(02)00258-4

ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

Wolvetang, E. J., Wilson, T. J., Sanij, E., Busciglio, J., Hatzistavrou, T., Hertzog, P. J. and Kola, I. (2003). ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Human Molecular Genetics, 12 (3), 247-255. doi: 10.1093/hmg/ddg015

Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

Wolvetang, E. J., Bradfield, O. M., Hatzistavrou, T., Crack, P. J., Busciglio, J., Kola, I. and Hertzog, P. J. (2003). Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. Neurobiology of Disease, 14 (3), 349-356. doi: 10.1016/S0969-9961(03)00107-4

Erratum: Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for down's syndrome, (Biochemical and Biophysical Research Communications (2001) 287:4 (1003-1008))

Sanij, E., Hatzistavrou, T., Hertzog, P., Kola, I. and Wolvetang, E. J. (2002). Erratum: Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for down's syndrome, (Biochemical and Biophysical Research Communications (2001) 287:4 (1003-1008)). Biochemical and Biophysical Research Communications, 291 (1)

Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for Down's syndrome (vol 287, pg 1003, 2001)

Sanij, E, Hatzistavrou, T, Hertzog, P, Kola, and Wolvetang, EJ (2002). Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for Down's syndrome (vol 287, pg 1003, 2001). Biochemical and Biophysical Research Communications, 291 (1), 191-191. doi: 10.1006/bbrc.2002.6411

Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for Down's Syndrome

Sanij, E., Hatzistavrou, T., Hertzog, P., Kola, I. and Wolvetang, E. J. (2001). Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: Implications for Down's Syndrome. Biochemical and Biophysical Research Communications, 287 (4), 1003-1008. doi: 10.1006/bbrc.2001.5680

Bone disease: Current knowledge and future prospects

Lazner, F., Wolvetang, E. J., Lazner, D. and Hertzog, P. (2001). Bone disease: Current knowledge and future prospects. Current Genomics, 2 (2), 91-124. doi: 10.2174/1389202013351048

Function of two gene families on human chromosome 21 and their potential contribution to Down syndrome

Hertzog, P. J., Pritchard, ., Wolvetang, E., Wilson, T., Owczarek, C. M. and Kola, I. (2001). Function of two gene families on human chromosome 21 and their potential contribution to Down syndrome. Cytogenetics and Cell Genetics, 92 (1-2), 12-12.

Regulation of apoptosis/proliferation and p53 by MIF in RA fibroblast-like synoviocytes

Lacey, D. C., YH, Yang, Hutchinson, P,, Wolvetang, E,, Leech, M, and Morand, E. F. (2001). Regulation of apoptosis/proliferation and p53 by MIF in RA fibroblast-like synoviocytes. Arthritis and Rheumatism, 49 (4), S158-S158.

Response of a primary human fibroblast cell line to H2O2: Senescence-like growth arrest or apoptosis

Bladier, C, Wolvetang, EJ, Hutchinson, P, deHaan, JB and Kola, I (1997). Response of a primary human fibroblast cell line to H2O2: Senescence-like growth arrest or apoptosis. Cell Growth & Differentiation, 8 (5), 589-598.

Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?

Bladier, C., Wolvetang, E. J., Hutchinson, P., de Haan, J. B. and Kola, I. (1997). Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?. Cell Growth and Differentiation, 8 (5), 589-598.

Effecters of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators

Vaillant, F, Larm, JA, McMullen, GL, Wolvetang, EJ and Lawen, A (1996). Effecters of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators. Journal of Bioenergetics and Biomembranes, 28 (6), 531-540. doi: 10.1007/BF02110443

Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin

Wolvetang, EJ, Larm, JA, Moutsoulas, P and Lawen, A (1996). Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin. Cell Growth & Differentiation, 7 (10), 1315-1325.

Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin

Wolvetang, E. J., Larm, J. A., Moutsoulas, P. and Lawen, A. (1996). Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin. Cell Growth and Differentiation, 7 (10), 1315-1325.

Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome

De Haan, Judy B., Wolvetang, Ernst J., Cristiano, Francesca, Iannello, Rocco, Bladier, Cecile, Kelner, Michael J. and Kola, Ismail (1996). Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome. Advances in Pharmacology, 38 (C), 379-402. doi: 10.1016/S1054-3589(08)60992-8

Didemnin-B Induces Cell-Death by Apoptosis - the Fastest Induction of Apoptosis Ever Described

Grubb, DR, Wolvetang, EJ and Lawen, A (1995). Didemnin-B Induces Cell-Death by Apoptosis - the Fastest Induction of Apoptosis Ever Described. Biochemical and Biophysical Research Communications, 215 (3), 1130-1136. doi: 10.1006/bbrc.1995.2580

Increase of Plasma-Membrane Oxidoreductase Activity Is Not Correlated with the Production of Extracellular-Superoxide Radicals in Human Namalwa Cells

Larm, JA, Wolvetang, EJ, Vaillant, F, Martinus, RD, Lawen, A and Linnane, AW (1995). Increase of Plasma-Membrane Oxidoreductase Activity Is Not Correlated with the Production of Extracellular-Superoxide Radicals in Human Namalwa Cells. Protoplasma, 184 (1-4), 173-180. doi: 10.1007/BF01276917

Mitochondrial Respiratory-Chain Inhibitors Induce Apoptosis

Wolvetang, EJ, Johnson, KL, Krauer, K, Ralph, SJ and Linnane, AW (1994). Mitochondrial Respiratory-Chain Inhibitors Induce Apoptosis. Febs Letters, 339 (1-2), 40-44. doi: 10.1016/0014-5793(94)80380-3

The Universality of Bioenergetic Disease - the Role of Mitochondrial Mutation and the Putative Interrelationship Between Mitochondria and Plasma-Membrane Nadh Oxidoreductase

Lawen, A, Martinus, RD, McMullen, GL, Nagley, P, Vaillant, F, Wolvetang, EJ and Linnane, AW (1994). The Universality of Bioenergetic Disease - the Role of Mitochondrial Mutation and the Putative Interrelationship Between Mitochondria and Plasma-Membrane Nadh Oxidoreductase. Molecular Aspects of Medicine, 15 (SUPPL. 1), 13-27. doi: 10.1016/0098-2997(94)90009-4

Latency of peroxisomal palmitoyl-CoA beta-oxidation in digitonin permeabilized fibroblasts: the effect of ATP on peroxisomal permeability

Wolvetang, E. J., Tager, J. M. and Wanders, R. J. (1992). Latency of peroxisomal palmitoyl-CoA beta-oxidation in digitonin permeabilized fibroblasts: the effect of ATP on peroxisomal permeability. Progress in Clinical and Biological Research, 375, 223-229.

Latency of peroxisomal palmitoyl-CoA beta-oxidation in digitonin permeabilized fibroblasts: the effect of ATP on peroxisomal permeability

Wolvetang, E. J., Tager, J. M. and Wanders, R. J. (1992). Latency of peroxisomal palmitoyl-CoA beta-oxidation in digitonin permeabilized fibroblasts: the effect of ATP on peroxisomal permeability. Progress in clinical and biological research, 375, 223-229.

Factors Influencing the Latency of the Peroxisomal Enzyme Dihydroxyacetone-Phosphate Acyltransferase (Dhap-At) in Permeabilized Human Skin Fibroblasts

Wolvetang, EJ, Tager, JM and Wanders, Rja (1991). Factors Influencing the Latency of the Peroxisomal Enzyme Dihydroxyacetone-Phosphate Acyltransferase (Dhap-At) in Permeabilized Human Skin Fibroblasts. Biochimica Et Biophysica Acta, 1095 (2), 122-126. doi: 10.1016/0167-4889(91)90074-8

Latency of the Peroxisomal Enzyme Acyl-Coa-Dihydroxyacetonephosphate Acyltransferase in Digitonin-Permeabilized Fibroblasts - the Effect of Atp and Atpase Inhibitors

Wolvetang, EJ, Tager, JM and Wanders, Rja (1990). Latency of the Peroxisomal Enzyme Acyl-Coa-Dihydroxyacetonephosphate Acyltransferase in Digitonin-Permeabilized Fibroblasts - the Effect of Atp and Atpase Inhibitors. Biochemical and Biophysical Research Communications, 170 (3), 1135-1143. doi: 10.1016/0006-291X(90)90511-K

Properties of the Atpase Activity Associated with Peroxisome-Enriched Fractions From Rat-Liver - Comparison with Mitochondrial F1F0-Atpase

Wolvetang, EJ, Wanders, Rja, Schutgens, Rbh, Berden, JA and Tager, JM (1990). Properties of the Atpase Activity Associated with Peroxisome-Enriched Fractions From Rat-Liver - Comparison with Mitochondrial F1F0-Atpase. Biochimica Et Biophysica Acta, 1035 (1), 6-11. doi: 10.1016/0304-4165(90)90166-T

3-Methyladenine, An Inhibitor of Autophagy, Has Multiple Effects On Metabolism

Caro, Lhp, Plomp, Pjam, Wolvetang, EJ, Kerkhof, C and Meijer, AJ (1988). 3-Methyladenine, An Inhibitor of Autophagy, Has Multiple Effects On Metabolism. European Journal of Biochemistry, 175 (2), 325-329. doi: 10.1111/j.1432-1033.1988.tb14200.x

Energy-Dependence of Autophagic Protein-Degradation in Isolated Rat Hepatocytes

Plomp, Pjam, Wolvetang, EJ, Groen, AK, Meijer, AJ, Gordon, PB and Seglen, PO (1987). Energy-Dependence of Autophagic Protein-Degradation in Isolated Rat Hepatocytes. European Journal of Biochemistry, 164 (1), 197-203. doi: 10.1111/j.1432-1033.1987.tb11011.x

Chemogenetic modulation of human in vitro motoneuron development accelerates maturation trajectory and electrophysical properties

Morrison, Sean, Shaker, Mohammed, Pietrogrande, Giovanni, Wolvetang, Ernst and Noakes, Peter (2023). Chemogenetic modulation of human in vitro motoneuron development accelerates maturation trajectory and electrophysical properties. ISN‐ESN 2023 Meeting, Porto, Portugal, 8‐11 August 2023. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

A human iPSC-based cardiac tissue model to understand age-related heart failure

Gopalakrishnan, Aswathi, Wolvetang, Ernst, Li, Joan and Cooper-White, Justin (2022). A human iPSC-based cardiac tissue model to understand age-related heart failure. Tissue Engineering and Regenerative Medicine International Society Asia Pacific Chapter Conference (TERMIS-AP), Jeju, South Korea, 5-8 October 2022. New Rochelle, NY, United States: Mary Ann Liebert.

Age-dependent changes in perivascular stem cells and the impacts of altered sensing on vascular ageing

Cooper-White, Justin, Chowdhury, Mahfuz, Wolvetang, Ernst and Veleva, Desi (2022). Age-dependent changes in perivascular stem cells and the impacts of altered sensing on vascular ageing. TERMIS 6th World Congress, Maastricht, Netherlands, 15-19 November 2021. New Rochelle, NY United States: Mary Ann Liebert.

Softer, faster, better! - Substrate mechanics drives superior somatic cell reprogramming outcomes

Cooper-White, Justin, Chowdhury, Mahfuz, Wolvetang, Ernst, Zimmerman, Samuel, Mar, Jessica, Polo, Jose, Laslett, Andrew and Nefzger, Christian (2022). Softer, faster, better! - Substrate mechanics drives superior somatic cell reprogramming outcomes. TERMIS 6th World Congress, Maastricht, Netherlands, 15-19 November 2021. New Rochelle, NY United States: Mary Ann Liebert.

Direct comparison of improved method for human induced pluripotent stem cell (IPSC) haematopoietic differentiation shows enhanced efficiency and sensitivity at reduced cost

Tursky, Melinda, Alateeq, Suad, Artuz, Crisbel, Loi, To Ha, Ma, David, Molloy, Tim, Tao, Helen and Wolvetang, Ernst (2021). Direct comparison of improved method for human induced pluripotent stem cell (IPSC) haematopoietic differentiation shows enhanced efficiency and sensitivity at reduced cost. ISEH 50th Annual Scientific Meeting, Online, 26 August - 30 November 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.exphem.2021.12.350

Thyroid hormone and TGF-? inhibition drive functional maturation of human pluripotent stem cell-derived hepatocytes

Withey, Sarah, Gerrard, Dave, Leeson, Hannah, Atkinson-Dell, Rebecca, Harrison, Sean, Baxter, Melissa, Al-Anbaki, Ali, Hanley, Karen Piper, Wolvetang, Ernst and Hanley., Neil (2020). Thyroid hormone and TGF-? inhibition drive functional maturation of human pluripotent stem cell-derived hepatocytes. EASL: The Digital International Liver Congress, Online, 27-29 August 2020. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s0168-8278(20)31000-x

Zika Virus sfRNA plays an essential role in the infection of insects and mammals

Slonchak, Andrii, Hugo, Leon E., Freney, Morgan, Amarilla, Alberto A., Hall-Mendelin, Sonja, Yan, Kexin, Torres, Francisco, Setoh, Yin Xiang, Peng, Nias, Chaggar, Harman K., Hurk, Andrew Van Den, Wolvetang, Ernst, Suhrbier, Andreas, Devine, Gregor J. and Khromykh, Alexander A. (2020). Zika Virus sfRNA plays an essential role in the infection of insects and mammals. Viruses 2020—Novel Concepts in Virology, Barcelona, Spain, 5–7 February 2020. Basel, Switzerland: MDPI. doi: 10.3390/proceedings2020050112

Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential

Shahsavari, A., Ovchinnikov, D., Wolvetang, E. and Whitworth, D. (2018). Immunomodulatory and anti-inflammatory capabilities of canine mesenchymal stem cells and their clinical potential. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: Wiley.

Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency

Weeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry, Wolvetang, Ernst and Whitworth, Deanne (2018). Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: Wiley.

Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brain

Woodruff, Trent M., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Leel, John D., Sepehrband', Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Coulthard, Liam G. (2017). Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brain. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, 8-12 September 2017. Kidlington, Oxford United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.178

Chondro-inductive injectable hydrogels for stem cell-based intervertebral disc tissue engineering

Naidoo, Taryn, Frith, Jessica, Menzies, Donna, Pradal, Clementine, Cameron, Andrew, Wolvetang, Ernst, Grondahl, Lisbeth, Whitehead, Darryl, Gronthos, Stan, Zannettino, Andrew, Ghosh, Peter and Cooper-White, Justin (2016). Chondro-inductive injectable hydrogels for stem cell-based intervertebral disc tissue engineering. 10th World Biomaterials Congress, Montreal, Canada, 17-22 May 2016. Lausanne, Switzerland: Frontiers Research Foundation. doi: 10.3389/conf.fbioe.2016.01.02659

Neuroinflammation drives the neuronal degenerative phenotype in a rat model of Ataxia-telangiectasia

Quek, H., Luff, J., Cheung, K., Kozlov, S., Gatei, M., Lee, C. S., Bellingham, M., Noakes, P., Lim, Y. C., Barnett, N., Dingwall, S., Wolvetang, E., Mashimo, T., Roberts, T. and Lavin, M. (2016). Neuroinflammation drives the neuronal degenerative phenotype in a rat model of Ataxia-telangiectasia. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200

Reprogramming initiates mobilization of endogenous mutagenic LINE-1, Alu and SVA retrotransposons in human induced pluripotent stem cells with consequences for host gene expression

Schumann, Gerald, Jung-Klawitter, Sabine, Fuchs, Nina V., Upton, Kyle R., Munoz-Lopez, Martin, Shukla, Ruchi, Wang, Jichang, Garcia-Canadas, Marta, Lopez-Ruiz, Cesar, Gerhardt, Daniel J., Sebe, Attila, Grabundzija, Ivana, Gerdes, Patricia, Merkert, Sylvia, Pulgarin, Andres, Bock, Anja, Held, Ulrike, Witthuhn, Anett, Haase, Alexandra, Wolvetang, Ernst J., Martin, Ulrich, Ivics, Zoltan, Izsvak, Zsuzsanna, Garcia-Perez, J. and Faulkner, Geoffrey J. (2016). Reprogramming initiates mobilization of endogenous mutagenic LINE-1, Alu and SVA retrotransposons in human induced pluripotent stem cells with consequences for host gene expression. Frontiers of Retrovirology Conference 2016, Erlangen, Germany, 12 - 14 September 2016. London, United Kingdom: BioMed Central. doi: 10.1186/s12977-016-0294-5

Multiplexed Microbioreactor Arrays for Rapid Optimisation of Pluripotent Stem Cell Maintenance and Differentiation

Titmarsh, D., Glass, N., Hudson, J., Hidalgo, A., Porrello, E., Little, M., Wolvetang, E. and Cooper-White, J. (2015). Multiplexed Microbioreactor Arrays for Rapid Optimisation of Pluripotent Stem Cell Maintenance and Differentiation. 4th TERMIS World Congress, Boston Ma, Sep 08-11, 2015. NEW ROCHELLE: MARY ANN LIEBERT, INC.

Platypus Induced Pluripotent Stem Cells Reveal that Acquisition of SOX2 Responsiveness Facilitated Expansion of the Pluripotency Network During Mammalian Evolution

Whitworth, D. J., Gauthier, M.-E., Ovchinnikov, D. A., Grimmond, S. M., Marshall Graves, J. A. and Wolvetang, E. J. (2015). Platypus Induced Pluripotent Stem Cells Reveal that Acquisition of SOX2 Responsiveness Facilitated Expansion of the Pluripotency Network During Mammalian Evolution. Annual Meeting of the International Society for Stem Cell Research, Stockholm , Sweden, 24-27 June 2015.

Accelerating development of stem cell-derived therapies using multiplexed microbioreactor arrays

Titmarsh, P., Hudson, J., Frith, J.E., Padmanabhan, H., Hidalgo-Gonzalez, A., Glass, N., Ovchinnikov, D., Porrello, E., Wolvetang, E. and White, C.-J. (2014). Accelerating development of stem cell-derived therapies using multiplexed microbioreactor arrays. 4th International Conference on Stem Cell Engineering, Coronado, United States, 16-19 March 2014. New York, United States: American Institute of Chemical Engineers.

Generation of cellular models of Parkinson’s disease using induced-pluripotent stem cells derived from patients with monogenic disease

Blair, Nicholas, Gao, Stephen, Woodbridge, Paula, Wolvetang, Ernst, Vaughan, Christopher and Sue, Carolyn (2014). Generation of cellular models of Parkinson’s disease using induced-pluripotent stem cells derived from patients with monogenic disease. Australian and New Zealand Association of Neurologists (ANZAN) Annual Scientific Meeting, Adelaide, Australia, 18-22 May 2014. London, United Kingdom: Churchill Livingstone. doi: 10.1016/j.jocn.2014.06.088

A Separable Upstream Promoter of the Slc8a1 (NCX1) Gene Efficiently Marks Cardiac Cell Populations Derived from Human Pluripotent Stem Cells

Hidalgo-Gonzalez, Alejandro, Ovchinnikov, Dmitry A., Hudson, James, Cooper-White, Justin and Ernst, Wolvetang (2013). A Separable Upstream Promoter of the Slc8a1 (NCX1) Gene Efficiently Marks Cardiac Cell Populations Derived from Human Pluripotent Stem Cells. Scientific Sessions of the American Heart Association on Basic Cardiovascular Sciences, Las Vegas Nv, 22 - 25 July 2013. Baltimore, MD United States: Lippincott Williams & Wilkins.

FGF/ERK signalling induces X chromosome inactivation in LIF-dependent equine induced pluripotent stem cells

Whitworth, Deanne J., Ovchinnikov, Dmitry A., Sun, Jane, Fortuna, Patrick R. J. and Wolvetang, Ernst J. (2013). FGF/ERK signalling induces X chromosome inactivation in LIF-dependent equine induced pluripotent stem cells. ASSCR 2013: 6th Annual Meeting for Australasian Society for Stem Cell Research, South Bank, QLD, Australia, 27-29 October, 2013.

Enzyme mediated, oxidative crosslinking of multifunctional, branched PEG: Characterization, particle formation and stem cell encapsulation

Menzies, D. J., Cameron, A., Maisonneuve, B. G. C., Grondahl, L., Wolvetang, E. and Cooper-White, J. (2012). Enzyme mediated, oxidative crosslinking of multifunctional, branched PEG: Characterization, particle formation and stem cell encapsulation. 3rd TERMIS World Congress 2012, Vienna, Austria, 5-8 September 2012. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/term.1586

Expression of complement factors and functional C5a receptors in human embryonic stem cells, and induced pluripotent stem cells

Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2012). Expression of complement factors and functional C5a receptors in human embryonic stem cells, and induced pluripotent stem cells. 24th International Complement Workshop (ICW), Chania, Crete, Greece, 10-15 October 2012. Jena, Germany: Urban und Fischer Verlag. doi: 10.1016/j.imbio.2012.08.116

The generation of induced pluripotent stem cells from human CD34+ cells reveals a sex bias in reprogramming efficiency

Whitworth, D. J., Sun, J and Wolvetang, E. J. (2012). The generation of induced pluripotent stem cells from human CD34+ cells reveals a sex bias in reprogramming efficiency. Annual Meeting of the International Society for Stem Cell Research, Yokohama, Japan, 13-16 June 2012.

Full-factorial analysis of soluble factors maintaining human embryonic stem cells with a multiplexed microbioreactor array

Titmarsh D., Doran M., Wolvetang E. and Cooper-White J. (2009). Full-factorial analysis of soluble factors maintaining human embryonic stem cells with a multiplexed microbioreactor array. 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, Jeju, November 1, 2009-November 5, 2009. Chemical and Biological Microsystems Society.

Wnt signaling in human embryonic stem cells

Davidson, K. C., Daly, R., Wolvetang, E. J., Hearn, M. T. W. and Pera, M. F. (2006). Wnt signaling in human embryonic stem cells. Stem Cells in the Age of Fluorescence Technology: the 2005 ISAC* Samuel A. Latt Conference, Goldcoast, Queensland, Australia, 6–9 November, 2005. Hoboken, N.J.: Wiley-Liss. doi: 10.1002/cyto.a.20264

Regulation of apoptosis/proliferation and p53 by MIF in RA fibroblast-like synoviocytes

Lacey, DC, Yang, YH, Hutchinson, P, Wolvetang, E, Leech, M and Morand, EF (2001). Regulation of apoptosis/proliferation and p53 by MIF in RA fibroblast-like synoviocytes. NEW YORK: WILEY-LISS.

Latency of Peroxisomal Palmitoyl-Coa Beta-Oxidation in Digitonin Permeabilized Fibroblasts - the Effect of Atp On Peroxisomal Permeability

Wolvetang, EJ, Tager, JM and Wanders, Rja (1992). Latency of Peroxisomal Palmitoyl-Coa Beta-Oxidation in Digitonin Permeabilized Fibroblasts - the Effect of Atp On Peroxisomal Permeability. 2Nd International Symp On Clinical, Biochemical, and Molecular Aspects of Fatty Acid Oxidation, Philadelphia Pa, Nov, 1991. NEW YORK: WILEY-LISS, INC.

Brain cells transformed from blood: a cell model for investigating autism

Dawson, Paul A., Heussler, Helen, Wolvetang, Ernst, Lee, Soohyun and Thakar, Nilay (2016). Brain cells transformed from blood: a cell model for investigating autism. Brisbane, QLD, Australia: Autism CRC.