Professor Avril Robertson

Professor in Biotechnology

School of Chemistry and Molecular Biosciences
Faculty of Science

Affiliate Professor

Institute for Molecular Bioscience
a.robertson3@uq.edu.au
+61 7 336 54612

Overview

Qualifications

  • Higher Education Leadership, National Excellence in School Leadership Initiative
  • Graduate Certificate in Higher Education, The University of Queensland
  • Doctor of Philosophy, University of St Andrews
  • Master in Chemistry with First Class Honours, University of St Andrews

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Robertson, Avril A. B. (2018). Inhibiting inflammasomes with small molecules. Inflammasomes: clinical and therapeutic implications. (pp. 343-400) edited by Mario D. Cordero and Elísabet Alcocer-Gómez. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-89390-7_15

Journal Article

  • Li, Xaria X., Lee, John D., Massey, Nicholas L., Guan, Carolyn, Robertson, Avril A. B., Clark, Richard J. and Woodruff, Trent M. (2020). Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function. Biochemical Pharmacology 114156, 114156. doi: 10.1016/j.bcp.2020.114156

  • Bazley, Mikaela M., Logan, Michael, Baxter, Christina, Robertson, Avril A. B. and Blanchfield, Joanne T. (2020). Decontamination of fentanyl and fentanyl analogues in field and laboratory settings: a review of fentanyl degradation. Australian Journal of Chemistry doi: 10.1071/CH19669

  • Hill, James R., Shao, Xia, Massey, Nicholas L., Stauff, Jenelle, Sherman, Phillip S., Robertson, Avril A. B. and J. H. Scott, Peter (2020). Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals. Bioorganic and Medicinal Chemistry Letters, 30 (12) 127186, 127186. doi: 10.1016/j.bmcl.2020.127186

  • Chow, Seong H., Deo, Pankaj, Yeung, Amy T. Y., Kostoulias, Xenia P., Jeon, Yusun, Gao, Mei-Ling, Seidi, Azadeh, Olivier, Françios Alwyn Benson, Sridhar, Sushmita, Nethercott, Cara, Cameron, David, Robertson, Avril A. B., Robert, Remy, Mackay, Charles R., Traven, Ana, Jin, Zi-Bing, Hale, Christine, Dougan, Gordon, Peleg, Anton Y. and Naderer, Thomas (2020). Targeting NLRP3 and staphylococcal pore-forming toxin receptors in human-induced pluripotent stem cell-derived macrophages. Journal of Leukocyte Biology JLB.4MA0420-497R doi: 10.1002/jlb.4ma0420-497r

  • Ipseiz, Natacha, Pickering, Robert J., Rosas, Marcela, Tyrrell, Victoria J., Davies, Luke C., Orr, Selinda J., Czubala, Magdalena A., Fathalla, Dina, Robertson, Avril A. B., Bryant, Clare E., O'Donnell, Valerie and Taylor, Philip R. (2020). Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway. EMBO Journal, 39 (14) e103454, e103454. doi: 10.15252/embj.2019103454

  • Malhotra, Sunny, Costa, Carme, Eixarch, Herena, Keller, Christian W., Amman, Lukas, Martínez-Banaclocha, Helios, Midaglia, Luciana, Sarró, Eduard, Machín-Díaz, Isabel, Villar, Luisa M., Triviño, Juan Carlos, Oliver-Martos, Begoña, Parladé, Laura Navarro, Calvo-Barreiro, Laura, Matesanz, Fuencisla, Vandenbroeck, Koen, Urcelay, Elena, Martínez-Ginés, María-Luisa, Tejeda-Velarde, Amalia, Fissolo, Nicolás, Castilló, Joaquín, Sanchez, Alex, Robertson, Avril A. B., Clemente, Diego, Prinz, Marco, Pelegrin, Pablo, Lünemann, Jan D., Espejo, Carmen, Montalban, Xavier and Comabella, Manuel (2020). NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients. Brain, 143 (5), 1414-1430. doi: 10.1093/brain/awaa084

  • Ren, Pingping, Wu, Darrell, Appel, Richard, Zhang, Lin, Zhang, Chen, Luo, Wei, Robertson, Avril A B, Cooper, Matthew A., Coselli, Joseph S., Milewicz, Dianna M., Shen, Ying H. and LeMaire, Scott A. (2020). Targeting the NLRP3 inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in mice. Journal of the American Heart Association, 9 (7) doi: 10.1161/JAHA.119.014044

  • Hill, James R., Coll, Rebecca C., Schroder, Kate and Robertson, Avril A.B. (2020). Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe. Tetrahedron Letters, 61 (19) 151849, 151849. doi: 10.1016/j.tetlet.2020.151849

  • Reinke, Sören, Linge, Mary, Diebner, Hans H., Luksch, Hella, Glage, Silke, Gocht, Anne, Robertson, Avril A.B., Cooper, Matthew A., Hofmann, Sigrun R., Naumann, Ronald, Sarov, Mihail, Behrendt, Rayk, Roers, Axel, Pessler, Frank, Roesler, Joachim, Rösen-Wolff, Angela and Winkler, Stefan (2020). Non-canonical Caspase-1 signaling drives RIP2-dependent and TNF-α-mediated inflammation in vivo. Cell Reports, 30 (8), 2501-2511. doi: 10.1016/j.celrep.2020.01.090

  • Wooff, Yvette, Fernando, Nilisha, Wong, Josephine H. C., Dietrich, Catherine, Aggio-Bruce, Riemke, Chu-Tan, Joshua A., Robertson, Avril A. B., Doyle, Sarah L., Man, Si Ming and Natoli, Riccardo (2020). Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration. Scientific Reports, 10 (1) 2263, 2263. doi: 10.1038/s41598-020-58849-z

  • Fox, Daniel, Mathur, Anukriti, Xue, Yansong, Liu, Yunqi, Tan, Wei Hong, Feng, Shouya, Pandey, Abhimanu, Ngo, Chinh, Hayward, Jenni A., Atmosukarto, Ines I., Price, Jason D., Johnson, Matthew D., Jessberger, Nadja, Robertson, Avril A. B., Burgio, Gaetan, Tscharke, David C., Fox, Edward M., Leyton, Denisse L., Kaakoush, Nadeem O., Märtlbauer, Erwin, Leppla, Stephen H. and Man, Si Ming (2020). Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome. Nature Communications, 11 (1) 760, 760. doi: 10.1038/s41467-020-14534-3

  • Deora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728

  • Chenery, Alistair L., Alhallaf, Rafid, Agha, Zainab, Ajendra, Jesuthas, Parkinson, James E., Cooper, Martha M., Chan, Brian H. K., Eichenberger, Ramon M., Dent, Lindsay A., Robertson, Avril A. B., Kupz, Andreas, Brough, David, Loukas, Alex, Sutherland, Tara E., Allen, Judith E. and Giacomin, Paul R. (2019). Inflammasome-independent role for NLRP3 in controlling innate antihelminth immunity and tissue repair in the lung. Journal of Immunology, 203 (10), 2724-2734. doi: 10.4049/jimmunol.1900640

  • Marín-Aguilar, Fabiola, Castejón-Vega, Beatriz, Alcocer-Gómez, Elísabet, Lendines-Cordero, Debora, Cooper, Matthew A., de la Cruz, Patricia, Andújar-Pulido, Eloísa, Pérez-Alegre, Mónica, Muntané, Jordi, Pérez-Pulido, Antonio J., Ryffel, Bernhard, Robertson, Avril A. B., Ruiz-Cabello, Jesús, Bullón, Pedro and Cordero, Mario D (2019). NLRP3 inflammasome inhibition by MCC950 in aged mice improves health via enhanced autophagy and PPARα activity. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 75 (8), 1457-1464. doi: 10.1093/gerona/glz239

  • Greene, Elizabeth, Flees, Joshua, Dhamad, Ahmed, Alrubaye, Adnan, Hennigan, Stephen, Pleimann, Jason, Smeltzer, Mark, Murray, Sue, Kugel, Jennifer, Goodrich, James, Robertson, Avril, Wideman, Robert, Rhoads, Douglas and Dridi, Sami (2019). Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis. American Journal of Pathology, 189 (10), 2077-2089. doi: 10.1016/j.ajpath.2019.06.013

  • Skinner, Oliver P., Jurczyluk, Julie, Baker, Paul J., Masters, Seth L., Rios Wilks, Alicia G., Clearwater, Misaki S., Robertson, Avril A. B., Schroder, Kate, Mehr, Sam, Munoz, Marcia A. and Rogers, Michael J. (2019). Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes. Journal of Allergy and Clinical Immunology, 143 (6), 2315-2317.e3. doi: 10.1016/j.jaci.2019.02.013

  • Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7

  • Krishnan, Shalini M, Ling, Yeong H, Huuskes, Brooke M, Ferens, Dorota M, Saini, Narbada, Chan, Christopher T, Diep, Henry, Kett, Michelle M, Samuel, Chrishan S, Kemp-Harper, Barbara K, Robertson, Avril A B, Cooper, Matthew A, Peter, Karlheinz, Latz, Eicke, Mansell, Ashley S, Sobey, Christopher G, Drummond, Grant R and Vinh, Antony (2019). Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension. Cardiovascular Research, 115 (4), 776-787. doi: 10.1093/cvr/cvy252

  • Mathur, Anukriti, Feng, Shouya, Hayward, Jenni A., Ngo, Chinh, Fox, Daniel, Atmosukarto, Ines I., Price, Jason D., Schauer, Kristina, Märtlbauer, Erwin, Robertson, Avril A. B., Burgio, Gaetan, Fox, Edward M., Leppla, Stephen H., Kaakoush, Nadeem O. and Man, Si Ming (2019). A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome. Nature Microbiology, 4 (2), 362-374. doi: 10.1038/s41564-018-0318-0

  • Thygesen, Sara J., Takizawa, Karli E., Robertson, Avril A. B., Sester, David P. and Stacey, Katryn J. (2019). Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. Immunology and cell biology, 97 (1), 17-28. doi: 10.1111/imcb.12193

  • Chitty, Jessica L., Edwards, David J., Robertson, Avril A. B., Butler, Mark S., Duley, John A., Cooper, Matthew A. and Fraser, James A. (2019). Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection. Mycopathologia, 184 (2), 273-281. doi: 10.1007/s11046-018-0315-0

  • Schofield, Zoe V., Croker, Daniel, Robertson, Avril A. B., Massey, Nicholas L., Donovan, Chantal, Tee, Ernest, Edwards, David, Woodruff, Trent M., Halai, Reena, Hansbro, Philip M. and Cooper, Matthew A. (2018). Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling. Scientific Reports, 8 (1) 17819, 17819. doi: 10.1038/s41598-018-36242-1

  • Lee, James S., Robertson, Avril A. B., Cooper, Matthew A. and Khosrotehrani, Kiarash (2018). The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese mice. International Journal of Molecular Sciences, 19 (11) 3289, 3289. doi: 10.3390/ijms19113289

  • Gordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066

  • Fauzia, Eram, Barbhuyan, Tarun Kumar, Shrivastava, Amit Kumar, Kumar, Manish, Garg, Paarth, Khan, Mohsin Ali, Robertson, Avril A. B. and Raza, Syed Shadab (2018). Chick embryo: a preclinical model for understanding ischemia-reperfusion mechanism. Frontiers in Pharmacology, 9 (SEP) 1034, 1034. doi: 10.3389/fphar.2018.01034

  • Kummari, Lalith K., Butler, Mark S., Furlong, Emily, Blundell, Ross, Nouwens, Amanda, Silva, Alberto B., Kappler, Ulrike, Fraser, James A., Kobe, Bostjan, Cooper, Matthew A. and Robertson, Avril A.B. (2018). Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. Bioorganic and Medicinal Chemistry, 26 (20), 5408-5419. doi: 10.1016/j.bmc.2018.09.004

  • Perera, Agampodi Promoda, Fernando, Ruchira, Shinde, Tanvi, Gundamaraju, Rohit, Southam, Benjamin, Sohal, Sukhwinder Singh, Robertson, Avril A. B., Schroder, Kate, Kunde, Dale and Eri, Rajaraman (2018). MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. Scientific Reports, 8 (1) 8618, 8618. doi: 10.1038/s41598-018-26775-w

  • Alhallaf, Rafid, Agha, Zainab, Miller, Catherine M., Robertson, Avril A. B., Sotillo, Javier, Croese, John, Cooper, Matthew A., Masters, Seth L., Kupz, Andreas, Smith, Nicholas C., Loukas, Alex and Giacomin, Paul R. (2018). The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection. Cell Reports, 23 (4), 1085-1098. doi: 10.1016/j.celrep.2018.03.097

  • Hill, James R. and Robertson, Avril A. B. (2018). Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis. Journal of Medicinal Chemistry, 61 (16) acs.jmedchem.7b01561, 6945-6963. doi: 10.1021/acs.jmedchem.7b01561

  • Salla, Manohar, Butler, Mark S., Massey, Nicholas L., Reid, Janet C., Cooper, Matthew A. and Robertson, Avril A. B. (2018). Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950. Bioorganic and Medicinal Chemistry Letters, 28 (4), 793-795. doi: 10.1016/j.bmcl.2017.12.054

  • Chen, Alice C. -H., Tran, Hai B., Xi, Yang, Yerkovich, Stephanie T., Baines, Katherine J., Pizzutto, Susan J., Carroll, Melanie, Robertson, Avril A. B., Cooper, Matthew A., Schroder, Kate, Simpson, Jodie L., Gibson, Peter G., Hodge, Greg, Masters, Ian B., Buntain, Helen M., Petsky, Helen L., Prime, Samantha J., Chang, Anne B., Hodge, Sandra and Upham, John W. (2018). Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis. ERJ Open Research, 4 (1), 00130-2017. doi: 10.1183/23120541.00130-2017

  • Grinstein, Lev, Luksch, Hella, Schulze, Felix, Robertson, Avril A. B., Cooper, Matthew A., Rösen-Wolff, Angela and Winkler, Stefan (2017). An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes. Clinical Immunology, 191, 100-109. doi: 10.1016/j.clim.2017.11.011

  • Chitty, Jessica L., Butler, Mark S., Suboh, Azzah, Edwards, David J., Cooper, Matthew A., Fraser, James A. and Robertson, Avril A. B. (2017). Antimicrobial octapeptin C4 analogues active against Cryptococcus species. Antimicrobial agents and chemotherapy, 62 (2) e00986-17, 1-10. doi: 10.1128/AAC.00986-17

  • Chen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4

  • Hill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017). Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 (17), 1449-1457. doi: 10.1002/cmdc.201700270

  • Kim, Richard Y., Pinkerton, James W., Essilfie, Ama T., Robertson, Avril A. B., Baines, Katherine J., Brown, Alexandra C., Mayall, Jemma R., Ali, M. Khadem, Starkey, Malcolm R., Hansbro, Nicole G., Hirota, Jeremy A., Wood, Lisa G. , Simpson, Jodie L., Knight, Darryl A., Wark, Peter A., Gibson, Peter G., O'Neill, Luke A. J., Cooper, Matthew A., Horvat, Jay C. and Hansbro, Philip M. (2017). Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma. American Journal of Respiratory and Critical Care Medicine, 196 (3), 283-297. doi: 10.1164/rccm.201609-1830OC

  • Chitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994

  • Pavillard, Luis E., Cañadas-Lozano, Diego, Alcocer-Gómez, Elísabet, Marín-Aguilar, Fabiola, Pereira, Sheila, Robertson, Avril A. B., Muntané, Jordi, Ryffel, Bernhard, Cooper, Matthew A., Quiles, José L., Bullón, Pedro, Ruiz-Cabello, Jesús and Cordero, Mario D. (2017). NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget, 8 (59), 99740-99756. doi: 10.18632/oncotarget.20763

  • Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C., Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S., Gerich, Mark E., Mack, Matthias, Robertson, Avril A. B., Cooper, Matthew A., Furuta, Glenn T., Dinarello, Charles A., O'Neill, Luke A., Eltzschig, Holger K., Masters, Seth L. and McNamee, Eoin N. (2017). Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. Journal of Experimental Medicine, 214 (6), 1737-1752. doi: 10.1084/jem.20160462

  • Dinh, Quynh Nhu, Drummond, Grant R., Kemp-Harper, Barbara K., Diep, Henry, De Silva, T. Michael, Kim, Hyun Ah, Vinh, Antony, Robertson, Avril A. B., Cooper, Matthew A., Mansell, Ashley, Chrissobolis, Sophocles and Sobey, Christopher G. (2017). Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress. Aging, 9 (6), 1595-1606. doi: 10.18632/aging.101255

  • Mridha, Auvro R., Wree, Alexander, Robertson, Avril A. B., Yeh, Matthew M., Johnson, Casey D., Van Rooyen, Derrick M., Haczeyni, Fahrettin, Teoh, Narci C. -H., Savard, Christopher, Ioannou, George N., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., Feldstein, Ariel E. and Farrell, Geoffrey C. (2017). NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology, 66 (5), 1037-1046. doi: 10.1016/j.jhep.2017.01.022

  • Fuster, José J., MacLauchlan, Susan, Zuriaga, María A., Polackal, Maya N., Ostriker, Allison C., Chakraborty, Raja, Wu, Chia-Ling, Sano, Soichi, Muralidharan, Sujatha, Rius, Cristina, Vuong, Jacqueline, Jacob, Sophia, Muralidliar, Varsha, Robertson, Avril A. B., Cooper, Matthew A., Andres, Vicente, Hirschi, Karen K., Martin, Kathleen A. and Walsh, Kenneth (2017). Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice. Science, 355 (6327), 842-847. doi: 10.1126/science.aag1381

  • Chitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017). GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 (7), 3049-3059. doi: 10.1074/jbc.M116.767533

  • Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017). Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 (3), 346-359. doi: 10.1016/j.chembiol.2017.01.003

  • Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017). Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 e21221 doi: 10.7554/eLife.21221

  • Pinkerton, James W., Kim, Richard Y., Robertson, Avril A. B., Hirota, Jeremy A., Wood, Lisa G., Knight, Darryl A., Cooper, Matthew A., O'Neill, Luke A. J., Horvat, Jay C. and Hansbro, Philip M. (2017). Inflammasomes in the lung. Molecular Immunology, 86, 44-55. doi: 10.1016/j.molimm.2017.01.014

  • Pinar, Anita, Dowling, Jennifer K., Bitto, Natalie J., Robertson, Avril B., Latz, Eicke, Stewart, Cameron R., Drummond, Grant R., Cooper, Matthew A., McAuley, Julie L., Tate, Michelle D. and Mansell, Ashley (2017). PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasome. The Journal of Biological Chemistry, 292 (3), 826-836. doi: 10.1074/jbc.M116.756379

  • Song, Erfei, Jahng, James W. S., Chong, Lisa P., Sung, Hye K., Han, Meng, Luo, Cuiting, Wu, Donghai, Boo, Stellar, Hinz, Boris, Cooper, Matthew A., Robertson, Avril A. B., Berger, Thorsten, Mak, Tak W., George, Isaac, Schulze, P. Christian, Wang, Yu, Xu, Aimin and Sweeney, Gary (2017). Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge. American Journal of Translational Research, 9 (6) AJTR0048252, 2723-+.

  • Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng and List, Alan F. (2016). The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. Blood, 128 (25), 2960-2975. doi: 10.1182/blood-2016-07-730556

  • Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J. and Lynch, M. A. (2016). Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain, Behavior, and Immunity, 61, 306-316. doi: 10.1016/j.bbi.2016.12.014

  • Groß, Christina J., Mishra, Ritu, Schneider, Katharina S., Médard, Guillaume, Wettmarshausen, Jennifer, Dittlein, Daniela C., Shi, Hexin, Gorka, Oliver, Koenig, Paul-Albert, Fromm, Stephan, Magnani, Giovanni, Ćiković, Tamara, Hartjes, Lara, Smollich, Joachim, Robertson, Avril A. B., Cooper, Matthew A., Schmidt-Supprian, Marc, Schuster, Michael, Schroder, Kate, Broz, Petr, Traidl-Hoffmann, Claudia, Beutler, Bruce, Kuster, Bernhard, Ruland, Jürgen, Schneider, Sabine, Perocchi, Fabiana and Groß, Olaf (2016). K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity, 45 (4), 761-773. doi: 10.1016/j.immuni.2016.08.010

  • Salla, Manohar, Butler, Mark S., Pelingon, Ruby, Kaeslin, Geraldine, Croker, Daniel E., Reid, Janet C., Baek, Jong-Min, Bernhardt, Paul V., Gillam, Elizabeth M. J., Cooper, Matthew A. and Robertson, Avril A. B. (2016). Identification, synthesis, and biological evaluation of the major human metabolite of NLRP3 inflammasome inhibitor MCC950. ACS Medicinal Chemistry Letters, 7 (12), 1034-1038. doi: 10.1021/acsmedchemlett.6b00198

  • Blundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016). Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 (9), 651-663. doi: 10.1021/acsinfecdis.6b00121

  • LaRock, Christopher N., Todd, Jordan, LaRock, Doris L., Olson, Joshua, O’Donoghue, Anthony J., Robertson, Avril A. B., Cooper, Matthew A., Hoffman, Hal M. and Nizet, Victor (2016). IL-1beta is an innate immune sensor of microbial proteolysis. Science Immunology, 1 (2) eaah3539, eaah3539-eaah3539. doi: 10.1126/sciimmunol.aah3539

  • van Hout, Gerardus P. J., Bosch, Lena, Ellenbroek, Guilielmus H. J. M., de Haan, Judith J., van Solinge, Wouter W., Cooper, Matthew A., Arslan, Fatih, de Jager, Saskia C. A., Robertson, Avril A. B., Pasterkamp, Gerard and Hoefer, Imo E. (2016). The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. European Heart Journal, 38 (11), 1-10. doi: 10.1093/eurheartj/ehw247

  • Arbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210

  • Tate, Michelle D., Ong, James D. H., Dowling, Jennifer K., McAuley, Julie L., Robertson, Avril B., Latz, Eicke, Drummond, Grant R., Cooper, Matthew A., Hertzog, Paul J. and Mansell, Ashley (2016). Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition. Scientific Reports, 6 (1) 27912, 27912. doi: 10.1038/srep27912

  • Tucey, Timothy M., Verma-Guar, Jiyoti, Nguyen, Julie, Hewitt, Victoria L., Lo, Tricia L., Shingu-Vazquez, Miguel, Robertson, Avril A. B., Hill, James R., Pettolino, Filomena A., Beddoe, Travis, Cooper, Matthew A., Naderer, Thomas and Traven, Ana (2016). The endoplasmic reticulum-mitochondrion tether ERMES orchestrates fungal immune evasion, illuminating inflammasome responses to hyphal signals. mSphere, 1 (3) e00074-16, 1-18. doi: 10.1128/mSphere.00074-16

  • Gaidt, Moritz M., Ebert, Thomas S., Chauhan, Dhruv, Schmidt, Tobias, Schmid-Burgk, Jonathan L., Rapino, Francesca, Robertson, Avril A. B., Cooper, Matthew A., Graf, Thomas and Hornung, Veit (2016). Human monocytes engage an alternative inflammasome pathway. Immunity, 44 (4), 833-846. doi: 10.1016/j.immuni.2016.01.012

  • Schaale, K., Peters, K. M., Murthy, A. M., Fritzsche, A. K., Phan, M.-D., Totsika, M., Robertson, A. A. B., Nichols, K. B., Cooper, M. A., Stacey, K. J., Ulett, G. C., Schroder, K., Schembri, M. A. and Sweet, M. J. (2016). Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.. Mucosal Immunology, 9 (1), 124-136. doi: 10.1038/mi.2015.44

  • Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B, Tanzer, Marco J., Monteleone, Mercedes, Robertson, Avril A.B., Cooper, Matthew A., Alvarez-Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate and Masters, Seth L. (2015). NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology, 45 (10), 2918-2926. doi: 10.1002/eji.201545655

  • Krishnan, S. M., Dowling, J. K., Ling, Y. H., Diep, H., Chan, C. T., Ferens, D., Kett, M. M., Pinar, A., Samuel, C. S., Vinh, A., Arumugam, T. V., Hewitson, T. D., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Latz, E., Mansell, A., Sobey, C. G. and Drummond, G. R. (2015). The inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induce hypertension in mice. British Journal of Pharmacology, 173 (4), 752-765. doi: 10.1111/bph.13230

  • Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stütz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kästner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A. and O'Neill, Luke A. J. (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21 (3), 248-257. doi: 10.1038/nm.3806

  • Butler, Mark S., Robertson, Avril A. B. and Cooper, Matthew A. (2014). Natural product and natural product derived drugs in clinical trials. Natural Product Reports, 31 (11), 1612-1661. doi: 10.1039/c4np00064a

  • Greenhill, Claire J., Jones, Gareth W., Nowell, Mari A., Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul N., Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela, Taylor, Philip R., O'Neill, Luke A., Humphreys, Ian R., Williams, Anwen S. and Jones, Simon A. (2014). Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy, 16 (4) 419 doi: 10.1186/s13075-014-0419-y

  • Coll, R. C., Robertson, A. A.B., Butler, M., Cooper, M. and O'Neill, L. A.J. (2013). Erratum: The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS ONE, 8 (7) e29539 doi: 10.1371/annotation/78d328b9-2c8c-4978-84b1-7e6a0b12ada1

  • Mamidyala, Sreeman K., Ramu, Soumya, Huang, Johnny X., Robertson, Avril A. B. and Cooper, Matthew A. (2013). Efficient synthesis of anacardic acid analogues and their antibacterial activities. Bioorganic & Medicinal Chemistry Letters, 23 (6), 1667-1670. doi: 10.1016/j.bmcl.2013.01.074

  • Coll, Rebecca C., Robertson, Avril, Butler, Mark, Cooper, Matthew and O'Neill, Luke A. J. (2011). The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS ONE, 6 (12) e29539, e29539. doi: 10.1371/journal.pone.0029539

  • Robertson, Avril and Botting, Nigel P. (2006). The synthesis of glucosinolates deuterium labelled in the glucose fragment. Journal of Labelled Compounds and Radiopharmaceuticals, 49 (13), 1201-1211. doi: 10.1002/jlcr.1141

  • Bashford, Katherine E., Burton, Matthew B., Cameron, Stuart, Cooper, Anthony L., Hogg, Rebecca D., Kane, Peter D., MacManus, David A., Matrunola, Christopher A., Moody, Christopher J., Robertson, Avril A. B. and Warne, Mark R. (2003). The Bohlmann–Rahtz route to functionalised pyridine scaffolds and their use in library synthesis. Tetrahedron Letters, 44 (8), 1627-1629. doi: 10.1016/S0040-4039(03)00034-0

  • Kiddle, Guy, Bennett, Richard N., Botting, Nigel P., Davidson, Nicola E., Robertson, Avril A. B. and Wallsgrove, Roger M. (2001). High-performance liquid chromatographic separation of natural and synthetic desulphoglucosinolates and their chemical validation by UV, NMR and chemical ionisation-MS methods. Phytochemical Analysis, 12 (4), 226-242. doi: 10.1002/pca.589

  • Griffiths, D. W., Bain, H., Deighton, N., Botting, N. P. and Avril Robertson (2000). Evaluation of liquid chromatography–atmospheric pressure chemical ionisation–mass spectrometry for the identification and quantification of desulphoglucosinolates. Phytochemical Analysis, 11 (4), 216-225. doi: 10.1002/1099-1565(200007/08)11:4<216::AID-PCA526>3.3.CO;2-U

  • Robertson, Avril and Botting, Nigel P. (1999). Synthesis of deuterium labelled desulfoglucosinolates as internal standards for LC-MS analysis. Tetrahedron, 55 (46), 13269-13284. doi: 10.1016/S0040-4020(99)00817-0

Conference Publication

Other Outputs

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor