Dr Fernanda Caldas Cardoso

Research Fellow

Institute for Molecular Bioscience

Overview

Dr Fernanda Cardoso was awarded MSc in Molecular Pharmacology and PhD in Immunology and is part of the Institute for Molecular Bioscience at UQ where she develops therapies for complex neurological diseases. The strong background in drug discovery, design and development, and interdisciplinary training in the fields of pharmacology, immunology, and neuroscience provides Dr Cardoso with the skills needed to identify naturally occurring or synthetic bioactive molecules and to study their effects in human physiology with applications in neurologic disorders such as chronic pain, IBS and neurodegenerative diseases.

Before UQ, Dr Cardoso was part of the Queensland Institute for Medical Research holding a prestigious CAPES Postdoctoral Fellowship. She has also developed unique HTS platforms to identify membrane surface proteins and peptides targets of novel therapies to combat infectious diseases, and to develop drugs such as anti-inflammatories.

Dr Cardoso is currently part of the Chemistry and Structural Biology Division and manages a number of industry and academia projects studying ion channels modulators derived from natural repertoires and the development of novel effective drugs.

Research Interests

  • Multifunctional peptides and proteins from venoms
  • Structure-function of venom peptides and proteins
  • Development of high throughput screens for drug discovery
  • Voltage-gated ion channels (Nav, Cav)
  • Acetylcholine receptors (AChR)
  • Transient receptor potential channels (TRP)
  • Chronic and neuropathic pain - Mechanisms of pain and Therapeutics development
  • Irritable Bowel Syndrome - Therapeutics development
  • Motor Neuron Disease - Therapeutics development
  • Venomics and Bioactivity of Spiders, Cone snails and Snake venoms

Research Impacts

Dr Fernanda Cardoso's research has provided remarkable insights in the discovery biology of vaccines against tropical diseases, as well as in the identification of new agents for therapeutical use in complex disorders such as chronic pain and irritable bowel syndrome. Her discovery in vaccine research has the potential to improve the lives of millions of people in Africa, Asia and South America through a vaccine against schistosomiasis, and her research in ion channels modulators has provided unique leads for treating neuropathic pain disorders which could improve the lives of at least 10% of the world population.

Qualifications

  • Doctor of Philosophy, Universidade Federal de Minas Gerais
  • Masters of Biological Sciences, Universidade Federal de Minas Gerais
  • Bachelor of Biological Sciences, Universidade Federal de Minas Gerais

Publications

View all Publications

Supervision

View all Supervision

Available Projects

  • We have open positions for Honours, Master Coursework and PhD students to develop research projects in discovery, characterization and structure-function studies of bio-active compounds in animal venoms and other natural repertoires. Students will develop skills in high throughput cellular assays using fluorescence imaging assays, manual and automated whole-cell patch clamp electrophysiology, high performance liquid chromatography, mass spectometry, recombinant expression, peptide synthesis, amongst other state-of-the-art methods and techiniques. Students will also be involved in writting and figures preparation for research publications.

  • We have open positions for Honours, Master Coursework and PhD students to develop research in therapies for treating Chronic Pain, Visceral Pain and Motor Neuron Disease. These novel therapies will be developed from bio-active compounds targeting voltage-gated sodium and/or calcium channels. Students will develop skills in manual and automated whole-cell patch clamp electrophysiology, high performance liquid chromatography, mass spectometry, recombinant expression, peptide synthesis, amongst other state-of-the-art methods and techiniques. Students will also be involved in writting and figures preparation for research publications.

View all Available Projects

Publications

Book Chapter

  • Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. Ion channel drug discovery. (pp. 297-313) edited by Brian Cox and Martin Gosling. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849735087-00297

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • We have open positions for Honours, Master Coursework and PhD students to develop research projects in discovery, characterization and structure-function studies of bio-active compounds in animal venoms and other natural repertoires. Students will develop skills in high throughput cellular assays using fluorescence imaging assays, manual and automated whole-cell patch clamp electrophysiology, high performance liquid chromatography, mass spectometry, recombinant expression, peptide synthesis, amongst other state-of-the-art methods and techiniques. Students will also be involved in writting and figures preparation for research publications.

  • We have open positions for Honours, Master Coursework and PhD students to develop research in therapies for treating Chronic Pain, Visceral Pain and Motor Neuron Disease. These novel therapies will be developed from bio-active compounds targeting voltage-gated sodium and/or calcium channels. Students will develop skills in manual and automated whole-cell patch clamp electrophysiology, high performance liquid chromatography, mass spectometry, recombinant expression, peptide synthesis, amongst other state-of-the-art methods and techiniques. Students will also be involved in writting and figures preparation for research publications.