Professor Glenn King

Professorial Research Fellow - GL

Institute for Molecular Bioscience

Affiliated Professor

School of Chemistry and Molecular Biosciences
Faculty of Science
glenn.king@imb.uq.edu.au
+61 7 334 62025

Overview

Research Interests

  • Bugs and drugs
    Our research harnesses the chemistry of venoms from arthropod predators, such as spiders, scorpions and centipedes, to develop novel pharmaceuticals to treat chronic pain, epilepsy and stroke. Stroke is the second-leading cause of death worldwide. In addition, it causes an extremely high incidence of disability in surviving victims due to the brain damage suffered during stroke. Likewise, chronic pain is a huge medical problem that affects one in five adults. There are few drugs available for treating chronic pain, and many of these have limited efficacy and dose-limiting side effects. Animal venoms are a rich source of stable natural peptides that potently modulate the activity of a wide range of neuronal ion channels and receptors. We have the largest collection of arthropod venoms in the world, a high-throughput pipeline for venoms-based drug discovery, protocols for rapid protein expression and structure determination, and links to key laboratories for testing the efficacy of lead molecules in rodent models of pain, epilepsy and stroke. We are using these world-class resources to move us closer to achieving our aim of developing novel analgesics for pain relief, novel drugs for treating severe paediatric epilepsies, and novel neuroprotective agents for treating stroke victims. An equally important focus of our research is on helping to safeguard Australia’s agricultural crops and reduce the spread of disease from insect pests by discovering new environmentally friendly insecticides. Currently, arthropod pests destroy approximately 15 per cent of the world’s food supply and spread pernicious diseases such as dengue and malaria. Our work is finding better, safer ways to control disease-spreading pests and protect crops.

Qualifications

  • Bachelor of Science, The University of Sydney
  • Doctor of Philosophy, The University of Sydney

Publications

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Supervision

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Publications

Featured Publications

Book

  • King, Glenn F. ed. (2015). Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. RSC Drug Discovery Series, Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876

  • Kuchel, Philip W., Ralston, Gregory B., Bersten, Audrey M., Easterbrook-Smith, Simon B., Jones, Alan R., Montague, M. Dan, Slaytor, Michael B., Thomas, Micahel A. W., Wake, R. Gerard, Chappell, Douglas J., Christopherson, Richard I., Conigrave, Arthur D., Darvey, Ivan G., Guss, J. Mitchell, King, Glenn F., Morris, Michael B., Samman, Samir, Smith, Mark T., Szabados, Eve, Weiss, Anthony S. and Whitelaw, Emma (1998). Schaum's outline of theory and problems of biochemistry. 2nd ed. New York, United States: McGraw-Hill.

Book Chapter

  • Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra and King, Glenn F. (2017). A Strategy for production of correctly folded disulfide-rich peptides in the periplasm of E. coli. Heterologous Gene Expression in E. coli Methods and Protocols. (pp. 155-180) New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-6887-9_10

  • Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. Ion channel drug discovery. (pp. 297-313) edited by Brian Cox and Martin Gosling. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849735087-00297

  • King, Glenn (2015). Preface. Venoms to drugs: venom as a source for the development of human therapeutics. (pp. VII-IX) edited by Glenn F. King. Cambridge, United States: RSC. doi: 10.1039/9781849737876-FP007

  • Lavergne, Vincent, Alewood, Paul F., Mobli, Mehdi and King, Glenn F. (2015). The Structural Universe of Disulfide-Rich Venom Peptides. Venoms to Drugs : Venom as a Source for the Development of Human Therapeutics. (pp. 37-79) edited by King, Glenn F.. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00037

  • Smith, Jennifer J., Lau, Carus Ho Yee, Herzig, Volker, Ikonomopoulou, Maria P., Rash, Lachlan D. and King, Glenn F. (2015). Therapeutic applications of spider-venom peptides. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. (pp. 221-244) edited by Glenn F. King. Cambridge, United Kingdom: Royal Society of Chemistry.. doi: 10.1039/9781849737876-00221

  • Dutertre, Sebastien, Undheim, Eivind, Pineda, Sandy S., Jin, Ai-Hua (Jean), Lavergne, Vincent, Fry, Bryan G., Lewis, Richard J., Alewood, Paul F. and King, Glenn F. (2015). Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches. Venoms to Drugs. (pp. 80-96) edited by King, Glenn F. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00080

  • Lavergne, Vincent, King, Glenn F., Lewis, Richard J. and Alewood, Paul F. (2014). Peptide therapeutics from venomous creatures. Pain therapeutics: current and future treatment paradigms. (pp. 217-246) edited by Charlotte Allerton. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737715-00217

  • Herzig, Volker and King, Glenn F. (2013). The Neurotoxic Mode of Action of Venoms from the Spider Family Theraphosidae. Spider Ecophysiology. (pp. 203-215) edited by Wolfgang Nentwig. Heidelberg, Germany: Springer-Verlag. doi: 10.1007/978-3-642-33989-9_15

  • Mobli, Mehdi, Hoch, Jeffrey C. and King, Glenn F. (2011). Fast acquisition methods in multidimensional NMR. Biomolecular NMR spectroscopy. (pp. 305-337) edited by Andrew J. Dingley and Steven M. Pascal. Amsterdam , Netherlands: IOS Press. doi: 10.3233/978-1-60750-695-9-305

  • Herzig, V. and King, G. F. (2010). Addendum: Spider toxins and their potential for insect control. Insect pharmacology: Channels, receptors, toxins and enzymes. (pp. 119-123) edited by Lawrence I. Gilbert and Sarjeet S. Gill. London, U.K.: Academic Press.

  • King, Glenn F and Mehdi Mobli (2010). Determination of peptide and protein structures using NMR Spectroscopy. Comprehensive natural products II: Chemistry and biology. (pp. 280-325) edited by Lewis Mander and Hung-Wen Liu. Oxford, England: Elsevier Science & Technology Books. doi: 10.1016/B978-008045382-8.00653-5

  • Maggio, F., Sollod, B. L., Tedford, H. W. and King, G. F. (2010). Spider toxins and their potential for insect control. Insect pharmacology: Channels, receptors, toxins and enzymes. (pp. 101-118) edited by Lawrence I. Gilbert and Sarjeet S. Gill. London, U.K.: Academic Press.

  • Maciejewski, M.W., Stern, A. S., King, G. F. and Hoch, J. C. (2006). Nonuniform Sampling in Biomolecular NMR.. Modern Magnetic Resonance. (pp. 1287-1293) edited by Graham A. Webb. Dordrecht, The Netherland: Springer.

  • Maggio, F., Sollod, B. L., Tedford, H. W. and King, G. F. (2005). Spider toxins and their potential for insect control. Comprehensive molecular insect science. (pp. 221-238) edited by L. I. Gilbert, K. Iatrou and S. S. Gill. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B0-44-451924-6/00094-6

  • Guss, J. M. and King, G. F. (2003). Macromolecular structure determination: comparison of crystallography and NMR. Encyclopedia of the Human Genome. (pp. xx-xx) edited by David N. Cooper. Hoboken, N. J .: Wiley.

  • Wilce, Jackie A., Wake, R. Gerry and King, Glenn F. (2001). Termination of replication in bacteria. Encyclopedia of life sciences. (pp. 1-7) Hoboken, NJ, United States: John Wiley and Sons. doi: 10.1038/npg.els.0001056

  • Guss, J. Mitchell and King, Glenn F. (2000). Macromolecular structure determination: Comparison of crystallography and NMR. Encyclopedia of life sciences. (pp. 1-5) Hoboken, NJ, United States: John Wiley and Sons. doi: 10.1038/npg.els.0002716

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision