Dr. Halley Ravuri completed his Bachelor of Veterinary Science degree from the Orissa University of Agriculture and Technology, and a Master in Pharmacology and Toxicology from the Birsa Agricultural University, India. He recently finished his PhD in Veterinary Science at UQ in 2022. Before his PhD, he worked as a Research Associate in various research organizations for four years in India. His primary research was focused on developing cancer models for glioma (brain cancer), breast cancer, and melanoma in laboratory rodents, and investigating the efficacy of nano-particulated anticancer compounds. He is very experienced in maintaining, experimenting on laboratory rodents and has hands-on experience in research methodologies including ELISA, PCR, western blot analysis, histopathology, and bioanalytical analysis using HPLC instrumentation
His doctoral research was focused on transdermal drug delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) in veterinary species and evaluating the efficacy of novel transdermal formulations using mass spectrometry-based plasma proteomics and lipidomics. He has garnered tremendous interest and expertise in the use of advanced mass spectrometry instruments including LC-MS/MS, GC-MS, and LC-TOF-MS, for enabling both targeted and discovery analysis of proteins, drugs, and lipid metabolites in animal plasma/serum. He has also worked as a technical assistant at the Analytical Service Unit, School of Agriculture and Food Sciences, UQ, using mass spectrometry for the analysis of pesticides, and fatty acid composition in milk, soils, and food samples.
Dr. Halley Ravuri recently commenced at The School of Biomedical Sciences, Faculty of Medicine, UQ – as a Postdoctoral Research Fellow, under the supervision of Prof. Mark Midwinter. His current research goals are to characterize endothelial glycocalyx metabolites in serum/plasma using advanced mass spectrometry techniques, and also explore the pathophysiology of trauma and hemorrhagic shock using a proteomics-based approach. He also has a keen interest in exploring alternative in-vitro techniques to investigate endothelial glycocalyx, and examining the role of exosomes in trauma/hemorrhagic shock in animals and humans. His long-term goal is to establish himself as a translational proteomics expert in the field of plasma biomarker discovery and establish novel mass spectrometry methods and data analysis pipelines to improve the application of mass spectrometry research in the veterinary and translation biomedical sciences. He is an advocate of the use of mass spectrometry-based proteomics to contribute to the field of “One Health”; using veterinary species as translational models for studying human diseases. His future research goals include exploring viral proteomics to investigate and understand the virulence of viruses, characterise viral antibodies using mass spectrometry and studying physiological responses in animals, humans, and model organisms.
Journal Article: Plasma proteomic changes in response to surgical trauma and a novel transdermal analgesic treatment in dogs
Ravuri, Halley Gora, Sadowski, Pawel, Noor, Zainab, Satake, Nana and Mills, Paul C (2022). Plasma proteomic changes in response to surgical trauma and a novel transdermal analgesic treatment in dogs. Journal of Proteomics, 265 104648, 104648. doi: 10.1016/j.jprot.2022.104648
Other Outputs: Efficacy of transdermally delivered non-steroidal anti-inflammatory drugs (NSAID’s) in dogs
Ravuri, Halley Gora (2022). Efficacy of transdermally delivered non-steroidal anti-inflammatory drugs (NSAID’s) in dogs. PhD Thesis, School of Veterinary Science, The University of Queensland. doi: 10.14264/6a57fbf
Journal Article: Pharmacokinetic evaluation of a novel transdermal ketoprofen formulation in healthy dogs
Ravuri, Halley Gora, Satake, Nana, Balmanno, Alexandra, Skinner, Jazmine, Kempster, Samantha and Mills, Paul C. (2022). Pharmacokinetic evaluation of a novel transdermal ketoprofen formulation in healthy dogs. Pharmaceutics, 14 (3) 646, 646. doi: 10.3390/pharmaceutics14030646
(2022–2023) Boehringer Ingelheim Vetmedica GmbH
Proteomic profiling for culicoides induced hypersensitivity in horses
(2021–2023) Boehringer Ingelheim Vetmedica GmbH
Mass spectrometry based blood plasma prostanoids quantification in dogs
(2020–2022) Canine Research Foundation
Ravuri, Halley Gora, Sadowski, Pawel, Noor, Zainab, Satake, Nana and Mills, Paul C (2022). Plasma proteomic changes in response to surgical trauma and a novel transdermal analgesic treatment in dogs. Journal of Proteomics, 265 104648, 104648. doi: 10.1016/j.jprot.2022.104648
Pharmacokinetic evaluation of a novel transdermal ketoprofen formulation in healthy dogs
Ravuri, Halley Gora, Satake, Nana, Balmanno, Alexandra, Skinner, Jazmine, Kempster, Samantha and Mills, Paul C. (2022). Pharmacokinetic evaluation of a novel transdermal ketoprofen formulation in healthy dogs. Pharmaceutics, 14 (3) 646, 646. doi: 10.3390/pharmaceutics14030646
Ravuri, Halley Gora, Noor, Zainab, Mills, Paul C., Satake, Nana and Sadowski, Pawel (2022). Data-independent acquisition enables robust quantification of 400 proteins in non-depleted canine plasma. Proteomes, 10 (1) 9, 9. doi: 10.3390/proteomes10010009
Amireddy, Niharika, Puttapaka, Srinivas N., Vinnakota, Ravali L., Ravuri, Halley G., Thonda, Swaroop and Kalivendi, Shasi V. (2021). Correction: The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice. Journal of Biological Chemistry, 297 (1) 100864, 1-1. doi: 10.1016/j.jbc.2021.100864
Elechalawar, Chandra Kumar, Bhattacharya, Dwaipayan, Ahmed, Mohammed Tanveer, Gora, Halley, Sridharan, Kathyayani, Chaturbedy, Piyush, Sinha, Sarmistha Halder, Chandra Sekhar Jaggarapu, Madhan Mohan, Narayan, Kumar Pranav, Chakravarty, Sumana, Eswaramoorthy, Muthusamy, Kundu, Tapas Kumar and Banerjee, Rajkumar (2019). Dual targeting of folate receptor-expressing glioma tumor-associated macrophages and epithelial cells in the brain using a carbon nanosphere-cationic folate nanoconjugate. Nanoscale Advances, 1 (9), 3555-3567. doi: 10.1039/c9na00056a
Kadari, Amrita, Pooja, Deep, Gora, Ravuri Halley, Gudem, Sagarika, Kolapalli, Venkata Ramana Murthy, Kulhari, Hitesh and Sistla, Ramakrishna (2018). Design of multifunctional peptide collaborated and docetaxel loaded lipid nanoparticles for antiglioma therapy. European Journal of Pharmaceutics and Biopharmaceutics, 132, 168-179. doi: 10.1016/j.ejpb.2018.09.012
Mir, Salma Mukhtar, Sahu, Bidya Dhar, Koneru, Meghana, Kuncha, Madhusudana, Jerald, Mahesh Kumar, Ravuri, Halley Gora, Kanjilal, Sanjit and Sistla, Ramakrishna (2018). Supplementation of oat (Avena sativa L.) extract abates alcohol-induced acute liver injury in a mouse model. Nutrition Research, 54, 80-92. doi: 10.1016/j.nutres.2018.04.002
Mir, Salma Mukhtar, Ravuri, Halley Gora, Pradhan, Raj Kumar, Narra, Sairam, Kumar, Jerald Mahesh, Kuncha, Madhusudana, Kanjilal, Sanjit and Sistla, Ramakrishna (2018). Ferulic acid protects lipopolysaccharide-induced acute kidney injury by suppressing inflammatory events and upregulating antioxidant defenses in Balb/c mice. Biomedicine and Pharmacotherapy, 100, 304-315. doi: 10.1016/j.biopha.2018.01.169
Singh, Mayank Kumar, Pooja, Deep, Ravuri, Halley Gora, Gunukula, Anusha, Kulhari, Hitesh and Sistla, Ramakrishna (2018). Fabrication of surfactant-stabilized nanosuspension of naringenin to surpass its poor physiochemical properties and low oral bioavailability. Phytomedicine, 40, 48-54. doi: 10.1016/j.phymed.2017.12.021
Oestrogen receptor-mediated liposomal drug delivery for treating melanoma
Ganguly, Anirban, Rachamalla, Hari Krishna Reddy, Bhattacharya, Dwaipayan, Bhamidipati, Keerti, Pal, Abhishek, Ravuri, Halley Gora, Chakravarty, Sumana, Adhikari, Susanta Sekhar and Banerjee, Rajkumar (2018). Oestrogen receptor-mediated liposomal drug delivery for treating melanoma. Journal of Drug Targeting, 26 (5-6), 481-493. doi: 10.1080/1061186x.2018.1433679
Koneru, Meghana, Sahu, Bidya Dhar, Mir, Salma Mukhtar, Ravuri, Halley Gora, Kuncha, Madhusudana, Kumar, Jerald Mahesh, Kilari, Eswar Kumar and Sistla, Ramakrishna (2017). Capsaicin, the pungent principle of peppers, ameliorates alcohol-induced acute liver injury in mice via modulation of matrix metalloproteinases. Canadian Journal of Physiology and Pharmacology, 96 (4), 419-427. doi: 10.1139/cjpp-2017-0473
Bhunia, Sukanya, Vangala, Venugopal, Bhattacharya, Dwaipayan, Ravuri, Halley Gora, Kuncha, Madhusudana, Chakravarty, Sumana, Sistla, Ramakrishna and Chaudhuri, Arabinda (2017). Large Amino Acid Transporter 1 Selective Liposomes of l-DOPA Functionalized Amphiphile for Combating Glioblastoma. Molecular Pharmaceutics, 14 (11), 3834-3847. doi: 10.1021/acs.molpharmaceut.7b00569
Koneru, Meghana, Sahu, Bidya Dhar, Gudem, Sagarika, Kuncha, Madhusudana, Ravuri, Halley Gora, Kumar, Jerald Mahesh, Kilari, Eswar Kumar and Sistla, Ramakrishna (2017). Polydatin alleviates alcohol-induced acute liver injury in mice: Relevance of matrix metalloproteinases (MMPs) and hepatic antioxidants. Phytomedicine, 27, 23-32. doi: 10.1016/j.phymed.2017.01.013
Bacteriological analysis of drinking water from different sources in and around Ranchi, Jharkhand
Kerketta, Priscilla, Gora, Ravuri Halley, Baxla, Sushma Lalita, Kumari, Suruchi and Yadava, Rajendra (2015). Bacteriological analysis of drinking water from different sources in and around Ranchi, Jharkhand. Journal of Pure and Applied Microbiology, 9 (Special Edition), 327-332.
Hepatoprotective activity of Moringa oleifera against cadmium toxicity in rats
Toppo, Reetu, Roy, Birendra Kumar, Gora, Ravuri Halley, Baxla, Sushma Lalita and Kumar, Prabhat (2015). Hepatoprotective activity of Moringa oleifera against cadmium toxicity in rats. Veterinary World, 8 (4), 537-540. doi: 10.14202/vetworld.2015.537-540
Effect of Tephrosia Purpurea powder against arsenic induced toxicity in rats
Gora, Ravuri Halley, Baxla, Sushma Lalita, Kumar, Naveen, Kerketta, Priscilla and Roy, Birendra Kumar (2015). Effect of Tephrosia Purpurea powder against arsenic induced toxicity in rats. Indian Veterinary Journal, 92 (3), 19-21.
Kerketta, Priscilla, Gora, Ravuri Halley, Baxla, Sushma Lalita, Kumari, Suruchi and Yadava, Rajendra (2015). Antibiotic sensitivity test of E. coli isolated from drinking water from different sources in and around Ranchi, Jharkhand. Journal of Pure and Applied Microbiology, 9 (1), 827-830.
Hepatoprotective activity of Tephrosia purpurea against arsenic induced toxicity in rats
Gora, Ravuri Halley, Baxla, Sushma Lalita, Kerketta, Priscilla, Patnaik, Subhasree and Roy, Birendra Kumar (2014). Hepatoprotective activity of Tephrosia purpurea against arsenic induced toxicity in rats. Indian Journal of Pharmacology, 46 (2), 197-200. doi: 10.4103/0253-7613.129317
Ameliorative effect of Tephrosia purpurea in arsenic-induced nephrotoxicity in rats
Gora, Ravuri, Kerketta, Priscilla, Baxla, Sushma, Toppo, Reetu, Prasad, Raju, Patra, Pabitra and Roy, Birendra (2014). Ameliorative effect of Tephrosia purpurea in arsenic-induced nephrotoxicity in rats. Toxicology International, 21 (1), 78-83. doi: 10.4103/0971-6580.128807
Ameliorative potential of Tephrosia purpurea extract against arsenic induced toxicity in wistar rats
Gora, Ravuri Halley, Baxla, Sushma Lalita, Kerketta, Priscilla, Toppo, Reetu, Kumar, Naveen and Roy, Birendra Kumar (2013). Ameliorative potential of Tephrosia purpurea extract against arsenic induced toxicity in wistar rats. Veterinary World, 6 (8), 493-496. doi: 10.5455/vetworld.2013.493-496
Hepatoprotective effect of Curcuma longa against lead induced toxicity in Wistar rats
Baxla, S. L., Gora, R. H., Kerketta, P., Kumar, N., Roy, B. K. and Patra, P. H. (2013). Hepatoprotective effect of Curcuma longa against lead induced toxicity in Wistar rats. Veterinary World, 6 (9), 664-667. doi: 10.14202/vetworld.2013.664-667
Kerketta, Priscilla, Baxla, Sushma Lalita, Gora, Ravuri Halley, Kumari, Suruchi and Roushan, Rustam Kumar (2013). Analysis of physico-chemical properties and heavy metals in drinking water from different sources in and around Ranchi, Jharkhand, India. Veterinary World, 6 (7), 370-375. doi: 10.5455/vetworld.2013.370-375
Comprehensive dog plasma spectral libraries for SWATH-MS data acquisition
Ravuri, Halley, Satake, Nana, Mills, Paul C. and Sadowski, Pawel (2019). Comprehensive dog plasma spectral libraries for SWATH-MS data acquisition. Human Proteome Organisation World Congress (HUPO), Adelaide, SA Australia, 15-18 September 2019.
Generation of dog spectral library for plasma proteins: using SWATH-MS technique
Ravuri, Halley Gora, Satake, Nana, Sadowski, Pawel and Mills, Paul C. (2018). Generation of dog spectral library for plasma proteins: using SWATH-MS technique. 3rd Queensland Mass Spectrometry Conference, Brisbane, QLD Australia, 6-7 December 2018.
Efficacy of transdermally delivered non-steroidal anti-inflammatory drugs (NSAID’s) in dogs
Ravuri, Halley Gora (2022). Efficacy of transdermally delivered non-steroidal anti-inflammatory drugs (NSAID’s) in dogs. PhD Thesis, School of Veterinary Science, The University of Queensland. doi: 10.14264/6a57fbf
(2022–2023) Boehringer Ingelheim Vetmedica GmbH
Proteomic profiling for culicoides induced hypersensitivity in horses
(2021–2023) Boehringer Ingelheim Vetmedica GmbH
Mass spectrometry based blood plasma prostanoids quantification in dogs
(2020–2022) Canine Research Foundation
Development of novel transdermal analgesic (NSAIDs) formulations in dogs
(2018–2020) John & Mary Kibble Trust
Transdermal delivery of analgesics in the dog
Doctor Philosophy — Associate Advisor
Other advisors: