Associate Professor David Fielding

ATH - Associate Professor

Royal Brisbane Clinical Unit
Faculty of Medicine

Overview

I am a physician at RBWH where I did my undergraduate training. I subspecialised in THoracic Medicine with a focus on bronchoscopy. I helped to create a large interventional service here. Part of that inlcuded instituting endobronchial ultrasound ( EBUS), an Australian first, in 2003. This has become standard of care for diagnosing lung cancer.

My research has been centred on how specimens from EBUS can be optimised. I have had strong collaboration with UQCCR, Pathology Queensland and QIMR Berghofer. Our work has expanded on 2 fronts- 1. use of simple cytology smears as the source for panel molecular testing and 2. The expanded role of WES and WGS on these samples.

We have instituted a large Australia wide collaborative network who are collecting samples along with us( The Debutant studies).We have Cancer Council Australia / CCQ/ and NHMRC grants fr these studies

Research Interests

  • Lung Cancer Genomics
    The Debutant study is an Australia wide study ( based at RBWH and UQCCR and QIMR Berghofer) of maximising the utility of specimens for lung cancer genomics when they are collected at biopsy using Endobronchial ultrasound.

Research Impacts

Our work has proposed workflow solutions including use of diff quik smears as alternative samples to formalin base samples for genomic study

Our work has built upon the idea of smears being " what yiou see is what you get" as far as samples for genomics, and the way smear microscopy can predict DNA content of the samples, thereby alllowing decision making for genomic testing

We will also continue to build workflow solutions starting from small increasing to large panel, then WES, then WGS, hopefully putting these concepts into the clinic

Qualifications

  • MBBS, The University of Queensland

Publications

  • Herath, Samantha, Bashirzadeh, Farzad, Mahajan, Hema, Ing, Alvin and Fielding, David (2022). Using the GenCut core biopsy tool with the radial endobronchial ultrasound guide sheath enables a high-quality histology sample capable of programmed cell death ligand 1 (PD-L1) testing. Respirology Case Reports, 10 (5) e0935. doi: 10.1002/rcr2.935

  • Visan, Kekoolani S., Lobb, Richard J., Wen, Shu Wen, Bedo, Justin, Lima, Luize G., Krumeich, Sophie, Palma, Carlos, Ferguson, Kaltin, Green, Ben, Niland, Colleen, Cloonan, Nicole, Simpson, Peter T., McCart Reed, Amy E., Everitt, Sarah J., MacManus, Michael P., Hartel, Gunter, Salomon, Carlos, Lakhani, Sunil R., Fielding, David and Möller, Andreas (2022). Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients. Cancers, 14 (1) 257, 257. doi: 10.3390/cancers14010257

  • Torrego, Alfons, Herth, Felix J, Munoz-Fernandez, Ana M, Puente, Luis, Facciolongo, Nicola, Bicknell, Stephen, Novali, Mauro, Gasparini, Stefano, Bonifazi, Martina, Dheda, Keertan, Andreo, Felipe, Votruba, Praha, Langton, David, Flandes, Javier, Fielding, David, Bonta, Peter I, Skowasch, Dirk, Schulz, Christian, Darwiche, Kaid, McMullen, Edmund, Grubb, G. Mark and Niven, Robert (2021). Bronchial Thermoplasty Global Registry (BTGR): 2-year results. BMJ Open, 11 (12) e053854. doi: 10.1136/bmjopen-2021-053854

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Supervision

View all Supervision

Publications

Book

  • Kurimoto, Noriaki, Fielding, David I. K. and Musani, Ali I. (2010). Endobronchial Ultrasonography. Wiley-Blackwell. doi: 10.1002/9781444314366

Journal Article

Conference Publication

PhD and MPhil Supervision

Current Supervision

  • Master Philosophy — Associate Advisor