Dr Mitchell Stark

NHMRC Early Career Fellow

The University of Queensland Diamantina Institute
Faculty of Medicine
m.stark@uq.edu.au
+61 7 344 38027

Overview

Dr Mitchell Stark is a NHMRC Early Career Research Fellow from the University of Queensland Dermatology Research Centre. Dr Stark has a strong background in melanoma genomics research and has actively been working towards understanding the aetiology of melanoma for >18years; studying gene dysregulation during tumour progression along with predisposition to melanoma in families with high risk for melanoma development. More recently, his research focus involves identifying ‘melanoma-specific’ microRNAs that may be useful for clinical management of disease. In addition to miRNA signatures, one of his ongoing projects is studying the molecular hallmarks of growing and involuting naevi – the key to early detection of primary and invasive melanoma.

Qualifications

  • Doctor of Philosophy, Queensland University of Technology
  • Bachelor of Applied Science (Life Science), Queensland University of Technology

Publications

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Supervision

  • Master Philosophy

  • Master Philosophy

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Available Projects

  • A talented student with minimum 1-2yrs research experience is being sought to undertake a laboratory and bioinformatic project on a range of the following topics:

    • Melanoma and Naevi genomics and transcriptomics
    • microRNA analysis of the progression of early skin lesions toward SCC
    • Functional validation of molecular pathways involved in Seborrhoeic Keratosis development

    The prospective student must be supported with a post-graduate stipend/scholarship. The successful candidate may be eligible for a top-up scholarship.

    For more information, please contatct Dr Mitchell Stark via email only (m.stark@uq.edu.au)

View all Available Projects

Publications

Book Chapter

Journal Article

  • Tan, J. M., Tom, L. N., Jagirdar, K., Lambie, D., Schaider, H., Sturm, R. A., Soyer, H. P. and Stark, M. S. (2017) The BRAF and NRAS mutation prevalence in dermoscopic subtypes of acquired naevi reveals constitutive MAPK pathway activation. British Journal of Dermatology, . doi:10.1111/bjd.15809

  • Stark, Mitchell S. (2017) Melanoma treatment guided by a panel of microRNA biomarkers. Melanoma Management, 4 2: 71-74. doi:10.2217/mmt-2017-0006

  • Stark, Mitchell S., Tom, Lisa N., Boyle, Glen M., Bonazzi, Vanessa F., Soyer, H. Peter, Herington, Adrian C., Pollock, Pamela M. and Hayward, Nicholas K. (2016) The 'Melanoma-enriched' microRNA miR-4731-5p acts as a tumour suppressor. Oncotarget, 7 31: 49677-49687. doi:10.18632/oncotarget.10109

  • Stark, Mitchell S., Bonazzi, Vanessa F., Boyle, Glen M., Palmer, Jane M., Symmons, Judith, Lanagan, Catherine M., Schmidt, Christopher W., Herington, Adrian C., Ballotti, Robert, Pollock, Pamela M. and Hayward, Nicholas K. (2015) miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma. Oncotarget, 6 19: 17753-17763. doi:10.18632/oncotarget.3924

  • Tembe, Varsha, Schramm, Sarah-Jane, Stark, Mitchell, Patrick, Ellis, Jayaswal, Vivek, Tang, Yue Hang, Barbour, Andrew, Hayward, Nicholas K., Thompson, John F., Scolyer, Richard A., Yang, Yee Hwa and Mann, Graham J. (2015) MicroRNA and mRNA expression profiling in metastatic melanoma reveal associations with BRAF mutation and patient prognosis. Pigment Cell and Melanoma Research, 28 3: 254-266. doi:10.1111/pcmr.12343

  • Stark, Mitchell S., Klein, Kerenaftali, Weide, Benjamin, Haydu, Lauren E., Pflugfelder, Annette, Tang, Yue Hang, Palmer, Jane M., Whiteman, David C., Scolyer, Richard A., Mann, Graham J., Thompson, John F., Long, Georgina V., Barbour, Andrew P., Soyer, H. Peter, Garbe, Claus, Herington, Adrian, Pollock, Pamela M. and Hayward, Nicholas K. (2015) The Prognostic and Predictive Value of Melanoma-related MicroRNAs Using Tissue and Serum: A MicroRNA Expression Analysis. EBioMedicine, 2 7: 671-680. doi:10.1016/j.ebiom.2015.05.011

  • Aoude, Lauren G., Pritchard, Antonia L., Robles-Espinoza, Carla Daniela, Wadt, Karin, Harland, Mark, Choi, Jiyeon, Gartside, Michael, Quesada, Victor, Johansson, Peter, Palmer, Jane M., Ramsay, Andrew J., Zhang, Xijun, Jones, Kristine, Symmons, Judith, Holland, Elizabeth A., Schmid, Helen, Bonazzi, Vanessa, Woods, Susan, Dutton-Regester, Ken, Stark, Mitchell S., Snowden, Helen, van Doom, Remco, Montgomery, Grant W., Martin, Nicholas G., Keane, Thomas M., Lopez-Otin, Carlos, Gerdes, Anne-Marie, Olsson, Hakan, Ingvar, Christian, Borg, Ake, Gruis, Nelleke A., Trent, Jeffrey M., Jonsson, Goran, Bishop, D. Timothy, Mann, Graham J., Newton-Bishop, Julia A., Brown, Kevin M., Adams, David J. and Hayward, Nicholas K. (2015) Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. Journal of the National Cancer Institute, 107 2: 1-7. doi:10.1093/jnci/dju408

  • Stark, Mitchell S. (2014) miRNAs: back seat drivers no more. Pigment Cell & Melanoma Research, 27 4: 510-511. doi:10.1111/pcmr.12247

  • Robles-Espinoza, Carla Daniela, Harland, Mark, Ramsay, Andrew J, Aoude, Lauren G, Quesada, Víctor, Ding, Zhihao, Pooley, Karen A, Pritchard, Antonia L, Tiffen, Jessamy C, Petljak, Mia, Palmer, Jane M, Symmons, Judith, Johansson, Peter, Stark, Mitchell S., Gartside, Michael G, Snowden, Helen, Montgomery, Grant W, Martin, Nicholas G, Liu, Jimmy Z, Choi, Jiyeon, Makowski, Matthew, Brown, Kevin M, Dunning, Alison M, Keane, Thomas M, Lopez-Otin, Carlos, Gruis, Nelleke A, Hayward, Nicholas K, Bishop, D Timothy, Newton-Bishop, Julia A and Adams, David J (2014) POT1 loss-of-function variants predispose to familial melanoma. Nature Genetics, 46 5: 478-481. doi:10.1038/ng.2947

  • Dutton-Regester, K., Kakavand, H., Aoude, L.G., Stark, M.S., Gartside, M.G., Johansson, P., O'Connor, L., Lanagan, C., Tembe, V., Pupo, G.M., Haydu, L.E., Schmidt, C.W., Mann, G.J., Thompson, J.F., Scolyer, R.A. and Hayward, N.K. (2013) Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma. Pigment Cell and Melanoma Research, 26 6: 852-860. doi:10.1111/pcmr.12153

  • Mould, Arne W., Pang, Zhenyi, Pakusch, Miha, Tonks, Ian D., Stark, Mitchell, Carrie, Dianne, Mukhopadhyay, Pamela, Seidel, Annica, Ellis, Jonathan J., Deakin, Janine, Wakefield, Matthew J., Krause, Lutz, Blewitt, Marnie E. and Kay, Graham F. (2013) Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation. Epigenetics and Chromatin, 6 19: 1-16. doi:10.1186/1756-8935-6-19

  • Brooks, Kelly, Chia, Kee Ming, Spoerri, Loredana, Mukhopadhyay, Pamela, Wigan, Matthew, Stark, Mitchell, Pavey, Sandra and Gabrielli, Brian (2013) Defective decatenation checkpoint function is a common feature of melanoma. Journal of Investigative Dermatology, 134 1: 150-158. doi:10.1038/jid.2013.264

  • Dutton-Regester, Ken, Aoude, Lauren G., Nancarrow, Derek J., Stark, Mitchell S., O'Connor, Linda, Lanagan, Cathy, Pupo, Gulietta M., Tembe, Varsha, Carter, Candace D., O'Rourke, Michael, Scolyer, Richard A., Mann, Graham J., Schmidt, Christopher W., Herington, Adrian and Hayward, Nicholas K. (2012) Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene. Genes Chromosomes and Cancer, 51 5: 452-461. doi:10.1002/gcc.21932

  • Bonazzi, Vanessa F., Stark, Mitchell S. and Hayward, Nicholas K. (2012) MicroRNA regulation of melanoma progression. Melanoma Research, 22 2: 101-113. doi:10.1097/CMR.0b013e32834f6fbb

  • Stark, Mitchell S., Woods, Susan L., Gartside, Michael G., Bonazzi, Vanessa F., Dutton-Regester, Ken, Aoude, Lauren G., Chow, Donald, Sereduk, Chris, Niemi, Natalie M., Tang, Nanyun, Ellis, Jonathan J., Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M., Pollak, Thomas, Youngkin, David, Brooks, Bradford R., Lanagan, Catherine, Schmidt, Christopher W., Kobe, Bostjan, MacKeigan, Jeffrey P., Yin, Hongwei, Brown, Kevin M., Gibbs, Richard, Trent, Jeffrey and Hayward, Nicholas K. (2012) Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics, 44 2: 165-169. doi:10.1038/ng.1041

  • Yokoyama, Satoru, Woods, Susan L., Boyle, Glen M., Aoude, Lauren G., MacGregor, Stuart, Zismann, Victoria, Gartside, Michael, Cust, Anne E., Haq, Rizwan, Harland, Mark, Taylor, John C., Duffy, David L., Holohan, Kelly, Dutton-Regester, Ken, Palmer, Jane M., Bonazzi, Vanessa, Stark, Mitchell S., Symmons, Judith, Law, Matthew H., Schmidt, Christopher, Lanagan, Cathy, O'Connor, Linda, Holland, Elizabeth A., Schmid, Helen, Maskiell, Judith A., Jetann, Jodie, Ferguson, Megan, Jenkins, Mark A., Kefford, Richard F., Giles, Graham G., Armstrong, Bruce K., Aitken, Joanne F., Hopper, John L., Whiteman, David C., Pharoah, Paul D., Easton, Douglas F., Dunning, Alison M., Newton-Bishop, Julia A., Montgomery, Grant W., Martin, Nicholas G., Mann, Graham J., Bishop, D. Timothy, Tsao, Hensin, Trent, Jeffrey M., Fisher, David E., Hayward, Nicholas K. and Brown, Kevin M. (2011) A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature, 480 7375: 99-103. doi:10.1038/nature10630

  • MacGregor, Stuart, Montgomery, Grant W., Liu, Jimmy Z., Zhao, Zhen Zhen, Henders, Anjali K., Stark, Mitchell, Schmid, Helen, Holland, Elizabeth A., Duffy, David L., Zhang, Mingfeng, Painter, Jodie N., Nyholt, Dale R., Maskiell, Judith A., Jetann, Jodie, Ferguson, Megan, Cust, Anne E., Jenkins, Mark A., Whiteman, David C., Olsson, Hakan, Puig, Susana, Bianchi-Scarra, Giovanna, Hansson, Johan, Demenais, Florence, Landi, Maria Teresa, Debniak, Tadeusz, Mackie, Rona, Azizi, Esther, Bressac-de Paillerets, Brigitte, Goldstein, Alisa M., Kanetsky, Peter A., Gruis, Nelleke A., Elder, David E., Newton-Bishop, Julia A., Bishop, D. Timothy, Iles, Mark M., Helsing, Per, Amos, Christopher I., Wei, Qingyi, Wang, Li-E, Lee, Jeffrey E., Qureshi, Abrar A., Kefford, Richard F., Giles, Graham G., Armstrong, Bruce K., Aitken, Joanne F., Han, Jiali, Hopper, John L., Trent, Jeffrey M., Brown, Kevin M., Martin, Nicholas G., Mann, Graham J., Hayward, NK and Hayward, Nicholas K. (2011) Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. Nature Genetics, 43 11: 1114-1118. doi:10.1038/ng.958

  • Bonazzi, Vanessa F., Nancarrow, Derek J., Stark, Mitchell S., Moser, Ralf J., Boyle, Glen M., Aoude, Lauren G., Schmidt, Christopher and Hayward, Nicholas K. (2011) Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma. PLoS One, 6 10: 1-9. doi:10.1371/journal.pone.0026121

  • Boyle, Glen M., Woods, Susan L., Bonazzi, Vanessa F., Stark, Mitchell S., Hacker, Elke, Aoude, Lauren G., Dutton-Regester, Ken, Cook, Anthony L., Sturm, Richard A. and Hayward, Nicholas K. (2011) Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell and Melanoma Research, 24 3: 525-537. doi:10.1111/j.1755-148X.2011.00849.x

  • Tyagi, Sonika, Stark, Mitchell S., Hayward, Nicholas K., Whiteman, David C. and Nancarrow, Derek J. (2010) WebFOG: A web tool to map genomic features onto genes. Biochemical and Biophysical Research Communications, 401 3: 447-450. doi:10.1016/j.bbrc.2010.09.077

  • Demenais, F., Mohamdi, H., Chaudru, V., Goldstein, A. M., Newton Bishop, J. A., Bishop, D. T., Kanetsky, P. A., Hayward, N. K., Gillanders, E., Elder, D. E., Avril, M. F., Azizi, E., van Belle, P., Bergman, W., Bianchi-Scarra, G., Brassac-de Paillerets, B., Calista, D., Carrera, C., Hansson, J., Harland, M., Hogg, D., Hoiom, V., Holland, E. A., Ingvar, C., Landi, M. T., Lang, J. M., Mackie, R. M., Mann, G. J., Ming, M. E., Njauw, C. J., Olsson, H., Palmer, J., Pastorino, L., Puig, S., Randerson-Moor, J., Stark, M., Tsao, H., Tucker, M. A., van der Velden, P., Yang, X. R., Gruis, N. and Melanoma Genetics Consortium (2010) Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: A GenoMEL study. Journal of the National Cancer Institute, 102 20: 1568-1583. doi:10.1093/jnci/djq363

  • Whiteman, DC, Parmar, P, Fahey, P, Moore, SP, Stark, M, Zhao, ZZ, Montgomery, GW, Green, AC, Hayward, NK, Webb, PM and Australian Canc Study (2010) Association of helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers. Gastroenterology, 139 1: 73-83. doi:10.1053/j.gastro.2010.04.009

  • Dry, Jonathan R., Pavey, Sandra, Pratilas, Christine A., Harbron, Chris, Runswick, Sarah, Hodgson, Darren, Chresta, Christine, McCormack, Rose, Byrne, Natalie, Cockerill, Mark, Graham, Alexander, Beran, Garry, Cassidy, Andrew, Haggerty, Carolyn, Brown, Helen, Ellison, Gillian, Dering, Judy, Taylor, Barry S., Stark, Mitchell, Bonazzi, Vanessa, Ravishankar, Sugandha, Packer, Leisl, Xing, Feng, Solit, David B., Finn, Richard S., Rosen, Neal, Hayward, Nicholas K., French, Tim and Smith, Paul D. (2010) Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244). Cancer Research, 70 6: 2264-2273. doi:10.1158/0008-5472.CAN-09-1577

  • Stark, Mitchell S., Tyagi, Sonika, Nancarrow, Derek J., Boyle, Glen M., Cook, Anthony L., Whiteman, David C., Parsons, Peter G., Schmidt, Christopher, Sturm, Richard A. and Hayward, Nicholas K. (2010) Characterization of the melanoma miRNAome by deep sequencing. PLoS One, 5 3: e9685-1-e9685-9. doi:10.1371/journal.pone.0009685

  • Bloethner, Sandra, Mould, Arne, Stark, Mitchell and Hayward, Nicholas K. (2008) Identification of ARHGEF17, DENND2D, FGFR3, and RBI mutations in melanoma by inhibition of nonsense-mediated mRNA decay. Genes, Chromosomes and Cancer, 47 12: 1076-1085. doi:10.1002/gcc.20598

  • Brown, K. M., MacGregor, S., Montgomery, G. W., Craig, D. W., Zhao, Z. Z., Iyadurai, K., Henders, A. K., Homer, N., Campbell, M. J., Stark, M., Thomas, S., Schmid, H., Maskiell, J. A., Jetann, J., Ferguson, M., Stephan, D. A., Cust, A. E., Whiteman, D. C., Green, A., Olsson, H., Puig, S., Ghiorzo, P., Hansson, J., Demenais, F., Goldstein, A. M., Gruis, N. A., Elder, D. E., Newton Bishop, J., Kefford, R. F., Giles, G. G., Armstrong, B. K., Aitken, J. F., Hopper, J. L., Martin, N. G., Trent, J. M., Mann, G. J. and Hayward, N. (2008) Common sequence variants on 20q11.22 confer melanoma susceptibility. Nature Genetics, 40 7: 838-840. doi:10.1038/ng.163

  • Doecke, James, Zhao, Zhen Zhen, Pandeya, Nirmala, Sadeghi, Shahram, Stark, Mitchell, Green, Adele C., Hayward, Nicholas K., Webb, Penlope M. and Whiteman, David C. (2008) Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma. International Journal of Cancer, 123 1: 174-180. doi:10.1002/ijc.23410

  • Harland, Mark, Goldstein, Alisa M., Kukalizch, Kairen, Taylor, Claire, Hogg, David, Puig, Susana, Badenas, Celia, Gruis, Nelleke, ter Huurne, Jeanet, Bergman, Wilma, Hayward, Nicholas K., Stark, Mitchell, Tsao, Hensin, Tucker, Margret A., Landi, Maria Teresa, Scarra, Giovanna B., Ghiorzo, Paola, Kanetsky, Peter A., Elder, David, Mann, Graham J., Holland, Elizabeth A., Bishop, D. Timothy and Newton Bishop, Julia (2008) A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL). European Journal of Cancer, 44 9: 1269-1274. doi:10.1016/j.ejca.2008.03.005

  • Sturm, Richard A., Duffy, David L., Zhao, Zhen Zhen, Leite, Fabio P.N., Stark, Mitchell S., Hayward, Nicholas K., Martin, Nicholas G. and Montgomery, Grant W. (2008) A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye colour. The American Journal of Human Genetics, 82 2: 424-431. doi:10.1016/j.ajhg.2007.11.005

  • Doecke, J D, Zhao, Z Z, Stark, M S, Green, A C, Hayward, N K, Montgomery, G W, Webb, P M and Whiteman, D C (2008) Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Cancer Epidemiology, Biomarkers & Prevention, 17 4: 1007-1012. doi:10.1158/1055-9965.EPI-08-0023

  • Nancarrow, Derek J., Handoko, Herlina Y., Stark, Mitchell S., Whiteman, David C. and Hayward, Nicholas K. (2007) SiDCoN: A tool to aide scoring of DNA copy number changes in SNP chip data. PLoS One, 2 10: . doi:10.1371/journal.pone.0001093

  • Packer, Leisl M., Pavey, Sandra J., Boyle, Glen M., Stark, Mitchell S., Ayub, Ana L., Rizos, Helen and Hayward, Nicholas K. (2007) Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF. International Journal of Cancer, 121 4: 784-790. doi:10.1002/ijc.22725

  • Pujana, M. A., Ruiz, A., Badenas, C., Puig-Butille, J-A., Nadal, M., Stark, M., Gomez, L., Valls, J., Sole, X., Hernandez, P., Cerrato, C., Madrigal, I., de Cid, R., Aguilar, H., Capella, G., Cal, S., James, M. R., Walker, G. J., Malvehy, J., Mila, M., Hayward, N. K., Estivill, X. and Puig, S. (2007) Molecular characterization of a t(9;12)(p21;q13) balanced chromosome translocation in combination with integrative genomics analysis identifies C9orf14 as a candidate tumor-suppressor. Genes, Chromosomes & Cancer, 46 2: 155-162. doi:10.1002/gcc.20396

  • Loffler, Kelly A., Biondi, Christine A., Gartside, Michael, Waring, Paul, Stark, Mitchell, Serewko-Auret, Magdalena M., Muller, H. Konrad, Hayward, Nicholas K. and Kay, Graham F. (2007) Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1. International Journal of Cancer, 120 2: 259-267. doi:10.1002/ijc.22288

  • Goldstein, Alisa M., Chan, May, Harland, Mark, Hayward, Nicholas K., Demenais, Florence, Bishop, D. Timothy, Azizi, Esther, Bergman, Wilma, Bianchi-Scarra, Giovanna, Bruno, William, Calista, Donato, Cannon Albright, Lisa A., Chaudru, Valerie, Chompret, Agnes, Cuellar, Francisco, Elder, David E., Ghiorzo, Paola, Gillanders, Elizabeth M., Gruis, Nelleke A., Hansson, Johan, Hogg, David, Holland, Elizabeth A., Kanetsky, Peter A., Kefford, Richard F., Landi, Maria T., Lang, Julie, Leachman, Sancy A., MacKie, Rona M., Magnusson, Veronica, Mann, Graham J., Bishop, Julia Newton, Palmer, Jane M., Puig, Susana, Puig-Butille, Joan A., Stark, Mitchell, Tsao, Hensin, Tucker, Margaret A., Whitaker, Linda, Yakobson, Emanuel, Ingvar, Christian, Borg, Ake, Westerdahl, Johan, Masback, Anna, Olsson, Hakan, Malvehy, Josep, Badenas, Celia, Cervera, Ramedios, Martí, Rosa, Brunet-Vidal, Joan, Yang, Guang, Martin, Nicholas, Whiteman, David, Green, Adele, Aitken, Joanne, Minghetti, Paola, Mantelli, Michela, Pastorino, Lorenza, Nasti, Sabina, Gargiulo, Sara, Gliori, Sara, Mistry, Sushila, Randerson-Moor, Juliette, de Snoo, Femke A., ter Huurne, Jeanet A. C., van der Rhee, Jasper, van Mourik, Leny, van Nieuwpoort, Frans, van der Drift, Clasine, Bressac-De Paillerets, Brigitte, Avril, Marie-Francoise, Grange, F., Sassolas, B., Boitier, F., Chevrant-Breton, J., Lasset, C., Dugast, C., Vabres, P., Ganguly, Arupa, Ming, Michael, Van Belle, Patricia, Platz, Anton, Egyhazi, Suzanne, Tuominen, Rainer, Linden, Diana, Schmid, Helen, Scope, Alon, Pavlotsky, Felix, Friedman, Eitan and Eliason, Mark (2007) Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. Journal of Medical Genetics, 44 2: 99-106. doi:10.1136/jmg.2006.043802

  • Stark, M. and Hayward, N. (2007) Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-denisty single-nucleotide polymorphism arrays. Cancer Research, 67 6: 2632-2642. doi:10.1158/0008-5472.CAN-06-4152

  • Lang, J, Hayward, N, Goldgar, D, Tsao, H, Hogg, D, Palmer, J, Stark, M, Tobias, ES and MacKie, R (2007) The M531 mutation in CDKN2A is a founder mutation that predominates in melanoma patients with Scottish ancestry. Genes Chromosomes & Cancer, 46 3: 277-287. doi:10.1002/gcc.20410

  • Goldstein, Alisa M., Chan, May, Harland, Mark, Gillanders, Elizabeth M., Hayward, Nicholas K., Avril, Marie-Francoise, Azizi, Esther, Bianchi-Scarra, Giovanna, Bishop, D. Timothy, Bressac-de Paillerets, Brigitte, Bruno, William, Calista, Donato, Cannon Albright, Lisa A., Demenais, Florence, Elder, David E., Ghiorzo, Paola, Gruis, Nelleke A., Hansson, Johan, Hogg, David, Holland, Elizabeth A., Kanetsky, Peter A., Kefford, Richard F., Landi, Maria Teresa, Lang, Julie, Leachman, Sancy A., MacKie, Rona M., Magnusson, Veronica, Mann, Graham J., Niendorf, Kristin, Newton Bishop, Julia, Palmer, Jane M., Puig, Susana, Puig-Butille, Joan A., de Snoo, Femke A., Stark, Mitchell, Tsao, Hensin, Tucker, Margaret A., Whitaker, Linda, Yakobson, Emanuel, The Lund Melanoma Study Group and Melanoma Genetics Consortium (GenoMEL) (2006) High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL. Cancer research, 66 20: 9818-9828. doi:10.1158/0008-5472.CAN-06-0494

  • Packer, Leisl, Pavey, Sandra, Parker, Andrew, Stark, Mitchell, Johansson, Peter, Clarke, Belinda, Pollock, Pamela, Ringner, Markus and Hayward, Nicholas (2006) Osteopontin is a Downstream Effector of the PI3-kinase Pathway in Melanomas that is Inversely Correlated with Functional PTEN. Carcinogenesis, 27 9: 1778-1786. doi:10.1093/carcin/bgl016

  • Curtin, John A., Stark, Mitchell S., Pinkel, Daniel, Hayward, Nicholas K. and Bastian, Boris C. (2006) PI3-Kinase Subunits Are Infrequent Somatic Targets in Melanoma. Journal of Investigative Dermatology, 126 7: 1660-1663. doi:10.1038/sj.jid.5700311

  • Stark, M., Puig-Butille, J. A., Walker, G., Badenas, C., Malvehy, J., Hayward , N. and Puig, S. (2006) Mutation of the tumour suppressor p33ING1b is rare in melanoma. British Journal of Dermatology, 155 1: 94-99. doi:10.1111/j.1365-2133.2006.07274.x

  • James, Michael R., Dumeni, Troy, Stark, Mitchell S., Duffy, David L., Montgomery, Grant W., Martin, Nicholas G. and Hayward, Nicholas K. (2006) Rapid screening of 4000 individuals for germ-line variations in the BRAF gene. Clinical Chemistry, 52 9: 1675-1678. doi:10.1373/clinchem.2006.070169

  • James, Michael R., Roth, Richard B., Shi, Michael M., Kammerer, Stefan, Nelson, Matthew R., Stark, Mitchell S., Dumenil, Troy, Montgomery, Grant W., Hayward, Nicholas K., Martin, Nicholas G., Braun, Andreas and Duffy, David L. (2005) BRAF Polymorphisms and Risk of Melanocytic Neoplasia. Journal of Investigative Dermatology, 125 6: 1252-1258. doi:10.1111/j.0022-202X.2005.23937.x

  • Zuidervaart, W., van Nieuwpoort, F., Stark, M., Dijkman, R., Packer, L., Borgstein, A. -M., Pavey, S., van der Velden, P., Out, C., Jager, M. J., Hayward, N. K. and Gruis, N. A. (2005) Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS. British Journal of Cancer, 92 11: 2032-2038. doi:10.1038/sj.bjc.6602598

  • Pavey, Sandra, Johansson, Peter, Packer, Leisl, Taylor, Jennifer, Stark, Mitchell, Pollock, Pamela M., Walker, Graeme J., Boyle, Glen M., Harper, Ursula, Cozzi, Sarah-Jane, Hansen, Katherine, Yudt, Laura, Schmidt, Chris, Hersey, Peter, Ellem, Kay A. O., O'Rourke, Michael G. E., Parsons, Peter G., Meltzer, Paul, Ringnér, Markus and Hayward, Nicholas K. (2004) Microarray expression profiling in melanoma reveals a BRAF mutation signature. Oncogene, 23 23: 4060-4067. doi:10.1038/sj.onc.1207563

  • Biondi, C. A., Gartside, M. G., Waring, P., Loffler, K. A., Stark, M. S., Magnuson, M. A., Kay, G. F. and Hayward, N. K. (2004) Conditional inactivation of the Men1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Molecular And Cellular Biology, 24 8: 3125-3131. doi:10.1128/MCB.24.8.3125-3131.2004

  • Vajdic, C, Kricker, A, Duffy, DL, Aitken, JF, Stark, M, ter Huurne, JAC, Martin, NG, Armstrong, BK and Hayward, NK (2003) Ocular melanoma is not associated with CDKN2A or MC1R variants - a population-based study. Melanoma Research, 13 4: 409-413. doi:10.1097/01.cmr.0000056244.56735.28

  • Pollock, Pamela M., Harper, Ursula L., Hansen, Katherine S., Yudt, Laura M., Stark, Mitchell, Robbins, Christiane M., Moses, Tracy Y., Hostetter, Galen, Wagner, Urs, Kakareka, John, Salem, Ghadi, Pohida, Tom, Heenan, Peter, Duray, Paul, Kallioniemi, Olli, Hayward, Nicholas K., Trent, Jeffrey M. and Meltzer, Paul S. (2003) High frequency of BRAF mutations in nevi. Nature Genetics, 33 1: 19-20. doi:10.1038/ng1054

  • Gillanders, Elizabeth, Juo, Suh-Hang Hank, Holland, Elizabeth A., Jones, MaryPat, Nancarrow, Derek, Freas-Lutz, Diana, Sood, Raman, Park, Naeun, Faruque, Mezbah, Markey, Carol, Kefford, Richard F., Palmer, Jane, Bergman, Wilma, Bishop, D. Timothy, Tucker, Margaret A., Bressac-de Paillerets, Brigitte, Hansson, Johan, The Lund Melanoma Study Group, Stark, Mitchell, Gruis, Nelleke, Newton Bishop, Julia, Goldstein, Alisa M., Bailey-Wilson, Joan E., Mann, Graham J., Hayward, Nicholas, Trent, Jeffrey, Martin, Nicholas G. and The Melanoma Genetics Consortium (2003) Localization of a novel melanoma susceptibility locus to 1p22. American Journal of Human Genetics, 73 2: 301-313. doi:10.1086/377140

  • Pollock, Pamela M., Stark, Mitchell S., Palmer, Jane M., Walters, Marilyn K., Aitken, Joanne F., Martin, Nicholas G. and Hayward, Nicholas K. (2001) Mutation analysis of the CDKN2A promoter in Australian melanoma families. Genes Chromosomes and Cancer, 32 1: 89-94. doi:10.1002/gcc.1170

  • Welch, John, Millar, Doug, Goldman, Alana, Heenan, Peter, Stark, Mitchell, Eldon, Michael, Clark, Susan, Martin, Nicholas G. and Hayward, Nicholas K. (2001) Lack of Genetic and Epigenetic Changes in CDKN2A in Melanocytic Nevi [Letter to the editor]. Journal of Investigative Dermatology, 117 2: 383-384. doi:10.1046/j.0022-202x.2001.01391.x

  • Box, N. F., Duffy, D. L., Chen, W., Stark, M., Martin, N. G., Sturm, R. A. and Hayward, N. K. (2001) MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. American Journal of Human Genetics, 69 4: 765-773. doi:10.1086/323412

Conference Publication

  • Emran, A. A., Menon, D. R., Marzese, D., Hammerlindl, H., Brafford, P., Stark, M., Huang, S., Hammerlindl, S., Gupta, D., Soyer, P., Sturm, R., Hoon, D., Gabrielli, B., Herlyn, M. and Schaider, H. (2016). Epigenetic remodelling of H3K9Me3 leads to early stress induced drug tolerance in cancer. In: Australasian Journal of Dermatology. , , (17-17). .

  • Stark, M., Gray, E., Ziman, M., Soyer, H. P. and Schaider, H. (2016). Can melanoma treatment be guided by a panel of predictive and prognostic microRNA biomarkers?. In: Melanoma Research. , , (E115-E115). .

  • Wright, C. M., Francis, S. M. Savarimuthu, Sriram, K. B., Stark, M. S., Hayward, N. K., Yang, I. A., Bowman, R. V. and Fong, K. M. (2013). Distinct profiles for lung cancer and its major subtypes. In: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, Darwin, NT, Australia, (23-23). 22-27 March 2013. doi:10.1111/resp.12045

  • Wright, C. M., Francis, S. M. S., Sriram, K. B., Quinn, K. R., Stark, M. S., Hayward, N. K., Yang, I. A., Bowman, R. V. and Fong, K. M. (2011). Mapping the lung cancer methylome. In: Supplement to Journal of Thoracic Oncology: 3rd Australian Lung Cancer Conference (ALCC). 3rd Australian Lung Cancer Conference (ALCC), Melbourne VIC, Australia, (S10-S10). 6-9 October 2010.

PhD and MPhil Supervision

Current Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • A talented student with minimum 1-2yrs research experience is being sought to undertake a laboratory and bioinformatic project on a range of the following topics:

    • Melanoma and Naevi genomics and transcriptomics
    • microRNA analysis of the progression of early skin lesions toward SCC
    • Functional validation of molecular pathways involved in Seborrhoeic Keratosis development

    The prospective student must be supported with a post-graduate stipend/scholarship. The successful candidate may be eligible for a top-up scholarship.

    For more information, please contatct Dr Mitchell Stark via email only (m.stark@uq.edu.au)