Dr Abu Sina

Postdoctoral Research Fellow

Australian Institute for Bioengineering and Nanotechnology
a.sina@uq.edu.au
+61 7 334 64176

Overview

Dr Abu Sina is currently a postdoctoral research fellow at the Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland. He obtained his PhD from the University of Queensland in 2017. He also has a teaching position as an Assistant Professor (equivalent to Senior Lecturer) at the Department of Biochemistry and Molecular Biology, Shahjalal University of Science & Technology, Bangladesh. Prior to joining the academia, he held positions in multinational companies such as Berger Paints and Beximco Limited. He is one of the main inventors of 10-minute universal cancer test which has been highlighted in >400 leading international news outlets inlucluding CNN, Forbes and The Guardian. He has a wide range of experiences in the industry, teaching and research with strong communication, team building, analytical and research skills. He published 26 research articles including 2 book chapters. Most of his works are published in high quality journals like Nature Communications (Impact Factor= 11.88), Accounts of Chemical Research (Impact Factor= 21.66), Biotechnology Advances (Impact Factor= 12.83), Trends in Molecular Medicine (Impact Factor 11.02), Biosensors and Bioelectronics (Impact Factor= 9.52), Nanoscale (Impact Factor= 6.97), Lab on a Chip (Impact Factor= 6.91) and Analytical Chemistry (Impact Factor= 6.04) etc. He presented his research works in several national and international conferences and seminars. He is also engaged in several social organizations. His vision is to develop the point of care diagnostic technologies for early detection of diseases which potentially could deliver a healthier and better life to the human.

Research Impacts

Dr. Abu Sina pioneered the interfacial biosensing techniques and recognized for his contribution to the field of bionanotechnology and molecular diagnostics. His research is focused on developing translational directed technologies which could have immediate clinical prospects. The impacts of his research particularly the recent discovery of universal cancer signature based 10 minute cancer test are outstanding. Examples include a successful NHMRC Investigator Grant ($639,750), Australian Research Council (ARC) Discovery Project Grant ($343000), Philanthropic Funding ($300,000), and an Australian Provisional Patent.

He has had several media appearances so far which includes interviews in national (Channel 9, Channel 7, ABC News, Fox News etc.) and international Television (CBC News, CTV News Canada etc.) and Radio (4EB, 4BC, ABC Perth, ABC Sunshine coast, SBS) outlets.His discovery on 10 minute cancer test has been selected by CNN and BioScope (an online magazine) as one of the “Top Discoveries/advances for 2018”.

Qualifications

  • Doctor of Philosophy, The University of Queensland

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

  • Methylation of DNA is a type of epigenetic signatures that defines the eukaryotic cell’s identity by regulating gene expression. Aberrant methylation in the genome can deregulate the gene expression pathways leading to diseases like cancer. Thus, DNA methylation has been regarded as one of the important biomarkers for cancer. Recent years have seen tremendous advancement in methylation based biomarker discovery providing abundant information about the genomic printing. However, cancer is a versatile disease that often needs multiple biomarker analysis for accurate detection. Current practice in detecting methylation biomarkers in clinic is largely affected by expensive sequencing technique. Recent advancements in electrochemical and optical biosensors have shown great promise in developing inexpensive multiplex platform. Despite of their significant improvement in sensitivity, these methods are restricted by major technological challenges including functionalization of sensor surface, long analysis procedure and invasive sampling. We have recently developed an interfacial biosensing technique to identify DNA methylation using gold-DNA affinity which obviates the need for sensor surface modification. In this study, we aim to develop a novel multiplex micro-device comprising an array of microelectrodes for directly detecting the genomic methylation biomarkers with the mechanism of interfacial adsorption between DNA and metal surfaces. These microelectrodes can significantly increase the assay sensitivity due to the high signal to noise ratio. We believe that this micro-fabricated multiplex platform will find broad applications as simple diagnostic tool in the clinic.

View all Available Projects

Publications

Book Chapter

Journal Article

Conference Publication

  • Shiddiky, Muhammad J, Sina, Abu Ali Ibn, Carracosa, Laura G, Palanisamy, Ramkumar, Rauf, Sakandar and Trau, Matt (2014). Methylsorb: A Simple Method for Quantifying DNA Methylation Using DNA-gold Affinity Interactions. In: ICECE 2014, 8th International Conference on Electrical and Computer Engineering. 8th International Conference on Electrical and Computer Engineering, Dhaka, Bangladesh, (17-20). 20-22 December 2014. doi:10.1109/ICECE.2014.7027002

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Methylation of DNA is a type of epigenetic signatures that defines the eukaryotic cell’s identity by regulating gene expression. Aberrant methylation in the genome can deregulate the gene expression pathways leading to diseases like cancer. Thus, DNA methylation has been regarded as one of the important biomarkers for cancer. Recent years have seen tremendous advancement in methylation based biomarker discovery providing abundant information about the genomic printing. However, cancer is a versatile disease that often needs multiple biomarker analysis for accurate detection. Current practice in detecting methylation biomarkers in clinic is largely affected by expensive sequencing technique. Recent advancements in electrochemical and optical biosensors have shown great promise in developing inexpensive multiplex platform. Despite of their significant improvement in sensitivity, these methods are restricted by major technological challenges including functionalization of sensor surface, long analysis procedure and invasive sampling. We have recently developed an interfacial biosensing technique to identify DNA methylation using gold-DNA affinity which obviates the need for sensor surface modification. In this study, we aim to develop a novel multiplex micro-device comprising an array of microelectrodes for directly detecting the genomic methylation biomarkers with the mechanism of interfacial adsorption between DNA and metal surfaces. These microelectrodes can significantly increase the assay sensitivity due to the high signal to noise ratio. We believe that this micro-fabricated multiplex platform will find broad applications as simple diagnostic tool in the clinic.