Dr James Kesby

Advance Queensland Research Fellow

Queensland Brain Institute

Affiliate Fellow

UQ Centre for Clinical Research
Faculty of Medicine
j.kesby@uq.edu.au
+61 7 334 66362

Overview

My research focusses on the neurochemical control of behaviour, particularly that involved in psychosis, schizophrenia and addiction. Through the investigation of developing dopamine pathways in experimental animal models my work aims to understand the abnormal circuitry in human neuropsychiatric disorders. Animal models provide an avenue to explore function and neurodevelopment using techniques that cannot be used in human subjects. However, interacting directly with clinicians and performing translational studies are key to putting these facts into context. As an Advance Queensland Research Fellow I work closely with clinical researchers focussed on the daunting task of understanding, identifying and treating early psychosis. This cross-disciplinary research collaboration continues to pursue better outcomes for people suffering from mental illness.

Research Interests

  • The role of early dopamine development in schizophrenia
    In collaboration with Professor Darryl Eyles and Associate Professor James Scott, we are trying to ascertain how early dopamine dysfunction can increase the risk of, or lead to, psychosis and schizophrenia.
  • Psychosis in schizophrenia: role of the associative striatum
    What are the underlying neurobiological processes that preceed psychosis in schizophrenia? I am interested in dopaminergic/glutamatergic dysfunction in the associative striatum and how we can use objective measures to improve diagnosis/treatment in schizophrenia.
  • Methamphetamine dependence: how different use patterns affect neurochemistry and cognition
    The use patterns of methamphetamine-dependent subjects (i.e., chronic use versus binge use) is rarely considered in clinical studies. My work aims to determine how these patterns of use differentially affect cognitive and neurochemical outcomes.

Qualifications

  • Bachelor of Science, The University of Queensland
  • Bachelor of Science with Honours First Class 1, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

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