Associate Professor Thomas Burne

conjoint Principal Research Fellow

Queensland Brain Institute
t.burne@uq.edu.au
+61 7 334 66371

Overview

A/Prof Burne obtained his PhD in Neurophysiology and Behaviour, under the supervision of Professor Lesley Rogers (DSc, FABiol,FAA), from the University of New England in 1997. He went on to study behavioural neuroscience in the UK at the Babraham Institute, Cambridge, UK. His postdoctoral work with Professors Steven Rose (Open University, UK) and Lawrence Wilkinson (University of Cambridge, UK) has provided him with the foundation for a well-regarded and flourishing program in behavioural neuroscience since his return to Australia in 2002. A/Prof Burne is now part of the Queensland Centre for Mental Health Research and has been with the Queensland Brain Institute since 2005. He has published over 90 referred papers and book chapters and, in collaboration with colleagues, attracted over $3 million in grant funding (including from the NHMRC and Brain Research Foundation). A/Prof Burne is a member of the University of Queensland Animal Ethics Committee, an Academic Editor for PLoS One and on the executive committee for the Australian Society for Psychiatric Research.

A/Prof Burne’s group studies brain development and behaviour in animal models to learn more about neuropsychiatric diseases, such as schizophrenia. Research is focused on investigating the underlying biological basis for schizophrenia, with the goal of finding public health interventions that will alleviate the burden of this disease. The group has been exploring the impact of developmental vitamin D (DVD) deficiency on brain development, the impact of adult vitamin D deficiency on brain function and behaviour and, more recently, the neurobiological affects of having an older father. A/Prof Burne’s research is carried out in close collaboration with Professor John McGrath and A/Prof Darryl Eyles, in a multidisciplinary team. Together they have an integrated research program using a broad range of neuroscientific techniques to explore potential causes of schizophrenia. There is a particular focus on early life, nongenetic risk factors and the team has skills in epidemiology, psychiatry, neuroanatomy, molecular biology, developmental biology and behavioural neuroscience. The Burne group is currently developing animal models related to risk factors for schizophrenia and autism.

Publications

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Featured Publications

Book

Book Chapter

  • Cui, Xiaoying, Eyles, Darryl W., Burne, Thomas H. J. and McGrath, John J. (2012). Developmental vitamin D deficiency as a risk factor for schizophrenia. In Alan S. Brown and Paul H. Patterson (Ed.), The origins of schizophrenia (pp. 282-299) New York, United States: Columbia University Press.

  • Eyles, Darryl, Burne, Thomas H.J., Alexander, Suzy, Cui, Xiaoying and McGrath, John J. (2011). The developmental vitamin D (DVD) model of schizophrenia. In Patricio O’Donnell and Wolfgang Walz (Ed.), Animal Models of Schizophrenia and Related Disorders (pp. 113-125) New York , NY, U.S.A.: Humana Press. doi:10.1007/978-1-61779-157-4_5

  • Eyles, Darryl, Burne, Thomas and McGrath, John (2011). Vitamin D: A neurosteroid affecting brain development and function; implications for neurological and psychiatric disorders. In David Feldman, J. Wesley Pike and John S. Adams (Ed.), Vitamin D 3rd ed. (pp. 565-582) Amsterdam, The Netherlands: Academic Press. doi:10.1016/B978-0-12-381978-9.10032-0

  • Burne, T. H. J., McGrath, J. J., MacKay-Sim, A. and Eyles, D. W. (2006). Prenatal Vitamin D Deficiency and Brain Development. In Veronica D. Stolzt (Ed.), Vitamin D: New Research 1 ed. (pp. 153-172) USA: Nova Science Publishers Inc.

  • Mackay-Sim, Alan, Feron, Francois, Eyles, Darryl, Burne, Thomas and McGrath, John (2004). Schizophrenia, vitamin D, and brain development. In John Smythies (Ed.), Disorders of Synaptic Plasticity And Schizophrenia (pp. 351-380) USA: Elsevier. doi:10.1016/S0074-7742(04)59014-1

Journal Article

Conference Publication

  • Lefevre, E., Josh, P., Eyles, D. and Burne, T. (2015). A proteomic study of the nucleus accumbens following sensitisation to MK-801 in the rat. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (188-189). 23-27 August 2015. doi:10.1111/jnc.13188

  • Moe, A. A. K., Cui, X., Kurniawan, N. D., Alexander, S., Burne, T. H. J. and Eyles, D. W. (2015). Differential short- and long-term behavioural effects of chronic antipsychotic treatment in adolescent and adult rats. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia Conference, (189-189). 23-27 August 2015. doi:10.1111/jnc.13188

  • Vega, M. S., Chong, S. and Burne, T. (2015). Does developmental vitamin d deficiency exacerbate the effects of second hit exposures?. In: 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns Australia, (191-191). Aug 23-27, 2015. doi:10.1111/jnc.13188

  • McGrath, John Joseph, Burne, T. H. and Eyles, D. W. (2011). Developmental Vitamin D deficiency and risk of schizophrenia: a ten-year update. In: Supplement to Schizophrenia Bulletin: Abstracts of the 13th International Congress on Schizophrenia Research (ICOSR). 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, (54-55). 2-6 April 2011. doi:10.1093/schbul/sbq173

  • Lanham, Stuart, Roberts, Carol, Habgood, Angela, Alexander, Suzanne, Burne, Thomas H. J., Eyles, Darryl W., Trueman, Clive N., Cooper, Matthew, Cooper, Cyrus, McGrath, John J. and Oreffo, Richard O. C. (2011). Maternal vitamin D deficiency effects offspring bone quality throughout the lifecourse. In: Program and Abstracts of the 7th World Congress on Developmental Origins of Health and Disease. World Congress on Developmental Origins of Health and Disease (7th, DOHaD, 2011), Portland, Oregon, U.S.A., (S89-S89). 18-21 September 2011. doi:10.1017/S2040174411000481

  • Eyles, Darryl, Calcagno, B., Formella, I., Van Swinderen, B., Scott, E., Burne, T. and McGrath, J. (2011). Modeling schizophrenia, dopamine ontogeny and the small brain. In: Supplement to Schizophrenia Bulletin: Abstracts of the 13th International Congress on Schizophrenia Research (ICOSR). 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, (105-105). 2-6 April 2011. doi:10.1093/schbul/sbq173

  • Burne, Thomas H., Turner, K., Alexander, S., Eyles, D. W. and McGrath, J. (2011). Modelling cognitive symptoms in the DVD-deficient rodent model of schizophrenia. In: Supplement to Schizophrenia Bulletin: Abstracts of the 13th International Congress on Schizophrenia Research (ICOSR). 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, (201-202). 2-6 April 2011. doi:10.1093/schbul/sbq173

  • Van Alphen, B., Burne, T. H. J., Eyles, D. W., Mattingley, J., McGrath, J. J. and van Swinderen, B. (2010). A high-throughput assay to measure sensorimotor gating (PPI) in Drosophila. In: ANS/AuPS 2010 – the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society, Sydney, NSW, Australia, (172-172). 31 January - 2 February 2010.

  • McGrath, John J., Saha, Sukanta, Burne, Thomas H.J. and Eyles, Darryl W. (2010). A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. In: Proceedings of the 14th Vitamin D Workshop. 14th Workshop on Vitamin D, Brugge, Belgiun, (471-477). 4-8 October, 2009. doi:10.1016/j.jsbmb.2010.03.073

  • Burne, Thomas H., Turner, Karly, McGrath, John J. and Eyles, Darryl W. (2010). Attentional performance of DVD-deficient rats in the 5-choice continuous performance test. In: H. A. Nasrallah and L. E. DeLisi, Schizophrenia Research. Proceedings of: 2nd Biennial Schizophrenia International Research Conference. 2nd Schizophrenia International Research Society Conference, Florence, Italy, (275-275). 10-14 April 2010. doi:10.1016/j.schres.2010.02.442

  • Eyles, Darryl, Cui, Xiaoying, Pelekanos, Matt, Kesby, James, Burne, Tom and McGrath, John (2010). Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny. In: H. A. Nasrallah and L. E. DeLisi, Schizophrenia Research. Proceedings of: 2nd Biennial Schizophrenia International Research Conference. 2nd Schizophrenia International Research Society Conference, Florence, Italy, (169-169). 10-14 April 2010. doi:10.1016/j.schres.2010.02.195

  • Harvey, Louise, Burne, Thomas H.J., McGrath, John J. and Eyles, Darryl W. (2010). Developmental vitamin D(3) deficiency induces alterations in immune organ morphology and function in adult offspring. In: J. Adamski, Proceedings of the 14th Vitamin D Workshop. 14th Vitamin D Workshop, Brugge, Belgium, (239-242). 4-8 October, 2009. doi:10.1016/j.jsbmb.2010.03.050

  • McGrath, John, Eyles, Darryl and Burne, Tom (2010). Environmental risk factors for schizophrenia : Does developmental vitamin D deficiency play a role?. In: 11th Australasian Schizophrenia Conference : Abstracts. 11th Australasian Schizophrenia Conference, Sydney, Australia, (A4-A4). 22-24 September 2010.

  • Burne, Thomas H. J., Turner, Karly, McGrath, John J. and Eyles, Darryl W. (2010). Modelling cognitive symptoms in developmental vitamin D-deficient rats. In: 11th Australasian Schizophrenia Conference : Abstracts. 11th Australasian Schizophrenia Conference, Sydney, Australia, (A13-A14). 22-24 September 2010.

  • McGrath, John J., Eyles, Darryl W., Pedersen, Carsten B., Anderson, Cameron, Ko, Pauline, Burne, Thomas H., Norgaard-Pedersen, Bent, Hougaard, David M. and Mortensen, Preben B. (2010). Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study. In: H. A. Nasrallah and L. E. DeLisi, Schizophrenia Research. 2nd Biennial Schizophrenia International Research Conference. 2nd Schizophrenia International Research Society Conference, Florence, Italy, (312-312). 10-14 April 2010. doi:10.1016/j.schres.2010.02.526

  • Burne, Tom, Foldi, C., Eyles, D. and McGrath, J. (2009). The Impact of Advanced Paternal Age On Intermediate Phenotypes Related to Neurodevelopmental Disorders. In: Schizophrenia Bulletin. 12th International Congress on Schizophrenia Research, San Diego Ca, (136-136). Mar 28-Apr 01, 2009.

  • McGrath, John Joseph, Barnett, A., Foldi, C., Burne, T. H., Eyles, D. W. and Buka, S. (2009). Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood in a general population birth cohort. In: Abstracts for the 12th International Congress on Schizophrenia Research (ICOSR). 12th International Congress on Schizophrenia Research (ICOSR), San Diego, United States, (73-73). 28 March -1 April 2009. doi:10.1093/schbul/sbn173

  • Eyles, D., Cui, X., Pelekanos, M., Kesby, J., Burne, T. and McGrath, J. (2009). Developmental Vitamin D Deficiency (DVD)and brain dopamine ontogeny. In: 12th International Congress on Schizophrenia Research, San Diego, CA, United States, (141-141). 28 March - 01 April 2009.

  • McGrath, John Joseph, Burne, T. H. and Eyles, D. W. (2009). The utility of animal models to explore the neurodevelopmental features of schizophrenia. In: Abstracts for the 12th International Congress on Schizophrenia Research (ICOSR). 12th International Congress on Schizophrenia Research (ICOSR), San Diego, United States, (144-144). 28 March -1 April 2009. doi:10.1093/schbul/sbn173

  • Foldi, Claire Jennifer, Cowin G, Kurniawan, Nyoman D., McGrath, John J., Eyles, Darryl and Burne, Thomas H.J. (2008). Advanced paternal age alters brain development and behaviour in C57BL/6J mice. In: Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society, Hobart , Tasmania, (). 27-30 January, 2008.

  • Harms, L., Cowin, G., Eyles, D., Kurniawan, N., Mackay-Sim, A., McGrath, J. and Burne T. (2008). Developmental vitamin D deficiency alters the trajectory of brain growth but not the response to psychomimetics in C57BL/6J mice. In: Australian Nueroscience Society Annual Meeting. Australian Nueroscience Society Annual Meeting, Hobart; Australia, (). 27-30 Jan 2008.

  • Kesby, J., O'Loan, J. C., McGrath, J. J., Eyles, D. W. and Burne, T. H. J. (2008). Developmental vitamin D deficiency in the rat induces a sexually dimorphic delayed onset in sensitivity to MK-801. In: Papers of the 21st ECNP Congress. 21st Congress of the European College of Neuropsychopharmacology, Barcelona, Spain, (S271-S272). 30 August - 3rd September 2008. doi:10.1016/S0924-977X(08)70354-7

  • Burne, T. H., O'Loan, J., Kesby, J., McGrath, J. J. and Eyles, D. W. (2007). Developmental vitamin D deficiency, postnatal development and adult behaviour in Sprague-Dawley rats. In: 10th International Congress on Schizophrenia Research, Savannah, GA, United States, (513-513). 02-06 April 2005.

  • Eyles, DW, Burne, T, Cui, X, Kesby, J, Ko, P and McGrath, J (2007). Developmental vitamin D deficiency; A candidate risk factor for schizophrenia. In: SCHIZOPHRENIA BULLETIN. 10th International Congress on Schizophrenia Research, Savannah GA, (316-317). APR 02-06, 2005.

  • Burne, T. H. J. (2006). Modeling cognitive deficits in schizophrenia using rodents. In: Australian and New Zealand Journal of Psychiatry. , , (A113-A114). .

  • Kesby, J. P., OLoan, J., Burne, T. H., McGrath, J. and Eyles, D. W. (2006). Developmental vitamin D Depletion alters adult rat behaviour and response to psychomimetic drugs: a relevant model for schizophrenia. In: Australian & New Zealand Journal of Psychiatry Supplement. Australasian Schizophrenia Conference, Fremantle, (A115-A115). 21-23 August 2006. doi:10.1111/j.1440-1614.2006.01859_2.x

  • Burne, T. H. J., Kesby, J., OLoan, J., McGrath, J. J., Mackay-Sim, A. and Eyles, D. W. (2006). Developmental vitamin D deficiency alters adult behaviour: An informative animal model of schizophrenia. In: T. J. Crow and S. R. Hirsch, Schizophrenia Research. XIIIth Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, (276-276). 4-10 February 2006. doi:10.1016/j.schres.2006.01.006

  • Eyles, D. W., O'Loan, J., Burne, T. H. J. and McGrath, J. (2006). The DVD animal model of schizophrenia: Early gestational hypovitaminosis D reduces neonatal brain GDNF. In: 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, (204-205). 4-10 February, 2006. doi:10.1016/j.schres.2006.01.006

  • Eyles, D. W., Ko, P., Kesby, J. P., Burne, H. J. and McGrath, J. (2006). The DVD animal model of schizophrenia: Effects of low maternal vitamin D on brain dopamine. In: T. J. Crow and S. R. Hirsch, Schizophrenia Research. XIIIth Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, (204-205). 4-10 February 2006. doi:10.1016/j.schres.2006.01.006

  • Murrell, W, Donnellan, M, Wetzig, A, Burne, T, Silburn, P and Mackay-Sim, A (2005). Adult stem cells from persons with Parkinson's disease are therapeutic in a rat model. In: Journal of the Neurological Sciences. 18th World Congress of Neurology, Sydney Australia, (S364-S364). Nov 05-11, 2005.

  • Burne, T. H. J., Eyles, D. W., Kesby, J. P., Mackay-Sim, A. and McGrath, J. J. (2005). Behavioural outcomes of transient prenatal vitmain D deficiency in rats. In: P. Martin, Proceedings of 25th Annual Meeting of the Australian Neuroscience Society. 25th Annual Meeting of the Australian Neuroscience Society, Perth, Western Australia, (66-66). 30 January - 2 February 2005.

  • Burne, T, McGrath, J. J., Mackay-Sim, A. and Eyles, D. W. (2005). Developmental vitamin D deficiency and brain development: An informative animal mode of schizophrenia. In: P.Joyce, Abstracts for the Royal Australian and New Zealand College of Psychiatrists Joint CINP/ASPR Scientific Meeting. Joint CINP/ASPR Scientific Meeting, Brisbane Convention Centre, Brisbane, (A2-A2). 7-9 Dec..

  • Burne, T., Kesby, J. P., Feron, F., Eyles, D. W., Mackay-Sim, A. and McGrath, J. (2005). Maternal dietary manipulation alters brain structure and function in offspring: the effect of low maternal vitamin D. In: P. Martin, Proceedings 25th Annual Meeting of the Australian Neuroscience Society. 25th Annual Meeting of the Australian Neuroscience Society, Perth, Western Australia, (36-36). 3 January - 2 February.

  • Kesby, J. P., Burne, T, Ko,, McGrath, J and Eyles, D. W. (2005). Prenatal vitamin D3 deficiency produces selective locomotion abnormalities in adult offspring. In: P. Martin, Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society, Perth, Western Australia, (118-118). 30 January - 2 February.

  • Ko, P., Kesby, J. P., Burne, T, McGrath, J. J. and Eyles, D. W. (2005). The effects of low maternal vitamin D on brain dopamine. In: Proceedings of 25th Annual Meeting of the Australian Neuroscience Society. 25th Annual Meeting of the Australian Neuroscience Society, Perth, Western Australia, (66-66). January 30 - 2 February 2005.

  • Rogers, E, Burne, T, McDrath, J and Eyles, DW (2004). Prenatal vitamin D deficiency induces hyperlocomotion and impairs PPI in adult offspring - A role for dopamine?. In: International Journal of Neuropsychopharmacology. 24th CINP Congress, Paris France, (S294-S295). Jun 20-24, 2004.

  • Burne, T. H. J., Eyles, D. W., Becker, A., Brown, J., Mackay-Sim, A. and McGrath, J. J. (2004). Behavioural outcomes of prenatal vitamin D deficiency in rats. In: Schizophrenia Research: 12th Biennial Winter Workshop on Schizophrenia. 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (117-118). 7-13 Feb 2004. doi:10.1016/j.schres.2003.10.001

  • Eyles, D. W., Burne, T., Mackay-Sim, A., McGrath, J. and Feron, F. (2004). Low prenatal vitamin D alters morphology, cell density and gene expression in adult rat brain: Correlations with schizophrenia. In: International Journal of Neuropsychopharmacology. XXIVth CINP Congress, Paris, France, (S436-S436). 20–24 June 2004.

  • Rogers, F, Burne, THJ, Eyles, DW and McGrath, JJ (2004). Prenatal vitamin D deficiency causes behavioural changes in adult offspring: Evidence of dopaminergic dysregulation. In: Schizophrenia research: proceedings of the XIIth Biennial Winter Workshop on Schizophrenia. XIIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (48-48). February 7-13, 2004. doi:10.1016/j.schres.2003.10.001

  • Eyles, D., Burne, T., Brown, J., Smith, E., Mackay-Sim, A., McGrath, J. and Feron, F. (2004). Transient prenatal and early life hypovitaminosis D induce permanent alterations in brain morphology, cell density and gene expression consistent with alterations observed in schizophrenia. In: H. A. Nasrallah and L. E. Delisi, Schizophrenia Research. 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (119-120). 7-13 Feb 2004. doi:10.1016/j.schres.2003.10.001

  • McGrath, John J., Feron, François P., Burne, Thomas H. J., Mackay-Sim, Alan and Eyles, Darryl W. (2004). Vitamin D-3 - implications for brain development. In: R. Bouillon, A. W. Norman and J. R. Pasqualini, The Journal of Steroid Biochemistry and Molecular Biology: Proceedings of the 12th Workshop on Vitamin D. 12th Workshop on Vitamin D, Maastricht, The Netherlands, (557-560). 06-10 July 2003. doi:10.1016/j.jsbmb.2004.03.070

  • Lambourne, S and Burne, T (2002). Neuropathological and behavioural analysis of transgenic mice bearing combined tau and APP mutations. In: Neurobiology of Aging. , , (S243-S243). .

  • Burne, THJ (2000). Expression of PGF-2-alpha receptor mRNA in the female pig brain. In: European Journal of Neuroscience. , , (407-407). .

  • Liu, LC, Ioannides, AA, Boers, F, Jahn, O, Rose, S, Burne, THJ and Ambler, T (1998). From vision to recall and speech: An MEG study without averaging. In: European Journal of Neuroscience. , , (155-155). .

  • Burne, THJ and Rogers, LJ (1996). Sex-dependent lateralization for odor perception. In: International Journal of Psychology. , , (3206-3206). .

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

Completed Supervision