Professor Darryl Eyles

Conjoint Professor

Queensland Brain Institute
d.eyles@uq.edu.au
+61 7 334 66370

Overview

Assoc Prof Darryl Eyles is the head of the Queensland Centre for Mental Health Research Developmental Neurobiology laboratory. Darryl’s research focuses exclusively on how known risk-factors for schizophrenia change the way the brain develops. His group have established the biological plausibility of various epidemiological risk factors for this disease. Much of the research focuses on the effects of developmental vitamin D, (DVD), deficiency on brain development. He also is interested in the effects Advanced Paternal Age and how this may relate to both autism and schizophrenia. Darryl has also established models of impaired dopaminergic development in the fly and zebra fish brains in order to investigate how the two major theories of schizophrenia namely the “Dopamine Hypothesis” and the “Neurodevelopmental Hypothesis“ of schizophrenia can be synthesised.

Research Impacts

The group approach is to create models based on known epidemiologically-informed risk factors for serious mental illness and examine brain structure at a gross, cellular and molecular level. These risk factors continue to be informed by major collaborations with a psychiatrist based at QBI, Prof John McGrath. In collaboration with Dr. Tom Burne the group attempts to understand how early changes in brain development could affect some basic (locomotor) and complex (learning and memory) animal behaviours.

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Graduate Diploma in Clinical Biochemistry, Griffith University
  • Bachelor of Science, Griffith University

Publications

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

  • Eyles, D.W. and Dean, A.J. (2016). Maternal Nutritional Deficiencies and Schizophrenia: Lessons from Animal Models with a Focus on Developmental Vitamin D Deficiency.. In Mikhail V. Pletnikov and John L. Waddington (Ed.), Modeling the Psychopathological Dimensions of Schizophrenia — From Molecules to Behavior (pp. 243-264) London, United Kingdom: Academic Press (Elsevier Inc). doi:10.1016/B978-0-12-800981-9.00015-8

  • Cui, Xiaoying, Eyles, Darryl W., Burne, Thomas H. J. and McGrath, John J. (2012). Developmental vitamin D deficiency as a risk factor for schizophrenia. In Alan S. Brown and Paul H. Patterson (Ed.), The origins of schizophrenia (pp. 282-299) New York, United States: Columbia University Press.

  • Eyles, Darryl, Burne, Thomas H.J., Alexander, Suzy, Cui, Xiaoying and McGrath, John J. (2011). The developmental vitamin D (DVD) model of schizophrenia. In Patricio O’Donnell and Wolfgang Walz (Ed.), Animal Models of Schizophrenia and Related Disorders (pp. 113-125) New York , NY, U.S.A.: Humana Press. doi:10.1007/978-1-61779-157-4_5

  • Eyles, Darryl, Burne, Thomas and McGrath, John (2011). Vitamin D: A neurosteroid affecting brain development and function; implications for neurological and psychiatric disorders. In David Feldman, J. Wesley Pike and John S. Adams (Ed.), Vitamin D 3rd ed. (pp. 565-582) Amsterdam, The Netherlands: Academic Press. doi:10.1016/B978-0-12-381978-9.10032-0

  • Burne, T. H. J., McGrath, J. J., MacKay-Sim, A. and Eyles, D. W. (2006). Prenatal Vitamin D Deficiency and Brain Development. In Veronica D. Stolzt (Ed.), Vitamin D: New Research 1 ed. (pp. 153-172) USA: Nova Science Publishers Inc.

  • Mackay-Sim, Alan, Feron, Francois, Eyles, Darryl, Burne, Thomas and McGrath, John (2004). Schizophrenia, vitamin D, and brain development. In John Smythies (Ed.), Disorders of Synaptic Plasticity And Schizophrenia (pp. 351-380) USA: Elsevier. doi:10.1016/S0074-7742(04)59014-1

Journal Article

Conference Publication

  • Lefevre, E., Josh, P., Eyles, D. and Burne, T. (2015). A proteomic study of the nucleus accumbens following sensitisation to MK-801 in the rat. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (188-189). 23-27 August 2015. doi:10.1111/jnc.13188

  • Moe, A. A. K., Cui, X., Kurniawan, N. D., Alexander, S., Burne, T. H. J. and Eyles, D. W. (2015). Differential short- and long-term behavioural effects of chronic antipsychotic treatment in adolescent and adult rats. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia Conference, (189-189). 23-27 August 2015. doi:10.1111/jnc.13188

  • Luan, W., Alexander, S., Osborne, G., Nink, V., Cui, X. and Eyles, D. (2015). Histo-cytometric analysis of prenatal mesencephalic dopaminergic terminal specification based on NURR1 and tyrosine hydroxylase. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (181-182). 23-27 August 2015. doi:10.1111/jnc.13188

  • Cui, X., Pertile, R. and Eyles, D. (2015). The association of the vitamin D receptor and nuclear matrix in a neuroblastoma line. In: 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian-Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, (252-252). 23-27 August 2015. doi:10.1111/jnc.13189

  • McGrath, John Joseph, Burne, T. H. and Eyles, D. W. (2011). Developmental Vitamin D deficiency and risk of schizophrenia: a ten-year update. In: Supplement to Schizophrenia Bulletin: Abstracts of the 13th International Congress on Schizophrenia Research (ICOSR). 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, (54-55). 2-6 April 2011. doi:10.1093/schbul/sbq173

  • Lanham, Stuart, Roberts, Carol, Habgood, Angela, Alexander, Suzanne, Burne, Thomas H. J., Eyles, Darryl W., Trueman, Clive N., Cooper, Matthew, Cooper, Cyrus, McGrath, John J. and Oreffo, Richard O. C. (2011). Maternal vitamin D deficiency effects offspring bone quality throughout the lifecourse. In: Program and Abstracts of the 7th World Congress on Developmental Origins of Health and Disease. World Congress on Developmental Origins of Health and Disease (7th, DOHaD, 2011), Portland, Oregon, U.S.A., (S89-S89). 18-21 September 2011. doi:10.1017/S2040174411000481

  • Eyles, Darryl, Calcagno, B., Formella, I., Van Swinderen, B., Scott, E., Burne, T. and McGrath, J. (2011). Modeling schizophrenia, dopamine ontogeny and the small brain. In: Supplement to Schizophrenia Bulletin: Abstracts of the 13th International Congress on Schizophrenia Research (ICOSR). 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, (105-105). 2-6 April 2011. doi:10.1093/schbul/sbq173

  • Burne, Thomas H., Turner, K., Alexander, S., Eyles, D. W. and McGrath, J. (2011). Modelling cognitive symptoms in the DVD-deficient rodent model of schizophrenia. In: Supplement to Schizophrenia Bulletin: Abstracts of the 13th International Congress on Schizophrenia Research (ICOSR). 13th International Congress on Schizophrenia Research (ICOSR), Colorado Springs CO, United States, (201-202). 2-6 April 2011. doi:10.1093/schbul/sbq173

  • Van Alphen, B., Burne, T. H. J., Eyles, D. W., Mattingley, J., McGrath, J. J. and van Swinderen, B. (2010). A high-throughput assay to measure sensorimotor gating (PPI) in Drosophila. In: ANS/AuPS 2010 – the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society, Sydney, NSW, Australia, (172-172). 31 January - 2 February 2010.

  • McGrath, John J., Saha, Sukanta, Burne, Thomas H.J. and Eyles, Darryl W. (2010). A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. In: Proceedings of the 14th Vitamin D Workshop. 14th Workshop on Vitamin D, Brugge, Belgiun, (471-477). 4-8 October, 2009. doi:10.1016/j.jsbmb.2010.03.073

  • Burne, Thomas H., Turner, Karly, McGrath, John J. and Eyles, Darryl W. (2010). Attentional performance of DVD-deficient rats in the 5-choice continuous performance test. In: H. A. Nasrallah and L. E. DeLisi, Schizophrenia Research. Proceedings of: 2nd Biennial Schizophrenia International Research Conference. 2nd Schizophrenia International Research Society Conference, Florence, Italy, (275-275). 10-14 April 2010. doi:10.1016/j.schres.2010.02.442

  • Eyles, Darryl, Cui, Xiaoying, Pelekanos, Matt, Kesby, James, Burne, Tom and McGrath, John (2010). Developmental vitamin D deficiency (DVD) and brain dopamine ontogeny. In: H. A. Nasrallah and L. E. DeLisi, Schizophrenia Research. Proceedings of: 2nd Biennial Schizophrenia International Research Conference. 2nd Schizophrenia International Research Society Conference, Florence, Italy, (169-169). 10-14 April 2010. doi:10.1016/j.schres.2010.02.195

  • Harvey, Louise, Burne, Thomas H.J., McGrath, John J. and Eyles, Darryl W. (2010). Developmental vitamin D(3) deficiency induces alterations in immune organ morphology and function in adult offspring. In: J. Adamski, Proceedings of the 14th Vitamin D Workshop. 14th Vitamin D Workshop, Brugge, Belgium, (239-242). 4-8 October, 2009. doi:10.1016/j.jsbmb.2010.03.050

  • McGrath, John, Eyles, Darryl and Burne, Tom (2010). Environmental risk factors for schizophrenia : Does developmental vitamin D deficiency play a role?. In: 11th Australasian Schizophrenia Conference : Abstracts. 11th Australasian Schizophrenia Conference, Sydney, Australia, (A4-A4). 22-24 September 2010.

  • Eyles, Darryl (2010). Modeling schizophrenia, go big or go small!. In: 11th Australasian Schizophrenia Conference : Abstracts. 11th Australasian Schizophrenia Conference, Sydney, Australia, (A20-A20). 22-24 September 2010.

  • Burne, Thomas H. J., Turner, Karly, McGrath, John J. and Eyles, Darryl W. (2010). Modelling cognitive symptoms in developmental vitamin D-deficient rats. In: 11th Australasian Schizophrenia Conference : Abstracts. 11th Australasian Schizophrenia Conference, Sydney, Australia, (A13-A14). 22-24 September 2010.

  • McGrath, John J., Eyles, Darryl W., Pedersen, Carsten B., Anderson, Cameron, Ko, Pauline, Burne, Thomas H., Norgaard-Pedersen, Bent, Hougaard, David M. and Mortensen, Preben B. (2010). Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study. In: H. A. Nasrallah and L. E. DeLisi, Schizophrenia Research. 2nd Biennial Schizophrenia International Research Conference. 2nd Schizophrenia International Research Society Conference, Florence, Italy, (312-312). 10-14 April 2010. doi:10.1016/j.schres.2010.02.526

  • Burne, Tom, Foldi, C., Eyles, D. and McGrath, J. (2009). The Impact of Advanced Paternal Age On Intermediate Phenotypes Related to Neurodevelopmental Disorders. In: Schizophrenia Bulletin. 12th International Congress on Schizophrenia Research, San Diego Ca, (136-136). Mar 28-Apr 01, 2009.

  • McGrath, John Joseph, Barnett, A., Foldi, C., Burne, T. H., Eyles, D. W. and Buka, S. (2009). Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood in a general population birth cohort. In: Abstracts for the 12th International Congress on Schizophrenia Research (ICOSR). 12th International Congress on Schizophrenia Research (ICOSR), San Diego, United States, (73-73). 28 March -1 April 2009. doi:10.1093/schbul/sbn173

  • Eyles, D., Cui, X., Pelekanos, M., Kesby, J., Burne, T. and McGrath, J. (2009). Developmental Vitamin D Deficiency (DVD)and brain dopamine ontogeny. In: 12th International Congress on Schizophrenia Research, San Diego, CA, United States, (141-141). 28 March - 01 April 2009.

  • McGrath, John Joseph, Burne, T. H. and Eyles, D. W. (2009). The utility of animal models to explore the neurodevelopmental features of schizophrenia. In: Abstracts for the 12th International Congress on Schizophrenia Research (ICOSR). 12th International Congress on Schizophrenia Research (ICOSR), San Diego, United States, (144-144). 28 March -1 April 2009. doi:10.1093/schbul/sbn173

  • Foldi, Claire Jennifer, Cowin G, Kurniawan, Nyoman D., McGrath, John J., Eyles, Darryl and Burne, Thomas H.J. (2008). Advanced paternal age alters brain development and behaviour in C57BL/6J mice. In: Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society, Hobart , Tasmania, (). 27-30 January, 2008.

  • Harms, L., Cowin, G., Eyles, D., Kurniawan, N., Mackay-Sim, A., McGrath, J. and Burne T. (2008). Developmental vitamin D deficiency alters the trajectory of brain growth but not the response to psychomimetics in C57BL/6J mice. In: Australian Nueroscience Society Annual Meeting. Australian Nueroscience Society Annual Meeting, Hobart; Australia, (). 27-30 Jan 2008.

  • Kesby, J., O'Loan, J. C., McGrath, J. J., Eyles, D. W. and Burne, T. H. J. (2008). Developmental vitamin D deficiency in the rat induces a sexually dimorphic delayed onset in sensitivity to MK-801. In: Papers of the 21st ECNP Congress. 21st Congress of the European College of Neuropsychopharmacology, Barcelona, Spain, (S271-S272). 30 August - 3rd September 2008. doi:10.1016/S0924-977X(08)70354-7

  • Eyles, DW, Burne, T, Cui, X, Kesby, J, Ko, P and McGrath, J (2007). Developmental vitamin D deficiency; A candidate risk factor for schizophrenia. In: SCHIZOPHRENIA BULLETIN. 10th International Congress on Schizophrenia Research, Savannah GA, (316-317). APR 02-06, 2005.

  • Eyles, D (2006). Animal models for schizophrenia, why do we bother?. In: Australian And New Zealand Journal of Psychiatry. ASC 2006, Fremantle, (A113-A113). 21-23 August 2006. doi:10.1111/j.1440-1614.2006.01859_2.x

  • Kesby, J. P., OLoan, J., Burne, T. H., McGrath, J. and Eyles, D. W. (2006). Developmental vitamin D Depletion alters adult rat behaviour and response to psychomimetic drugs: a relevant model for schizophrenia. In: Australian & New Zealand Journal of Psychiatry Supplement. Australasian Schizophrenia Conference, Fremantle, (A115-A115). 21-23 August 2006. doi:10.1111/j.1440-1614.2006.01859_2.x

  • Eyles, D. W., O'Loan, J., Burne, T. H. J. and McGrath, J. (2006). The DVD animal model of schizophrenia: Early gestational hypovitaminosis D reduces neonatal brain GDNF. In: 13th Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, (204-205). 4-10 February, 2006. doi:10.1016/j.schres.2006.01.006

  • Eyles, D. W., Ko, P., Kesby, J. P., Burne, H. J. and McGrath, J. (2006). The DVD animal model of schizophrenia: Effects of low maternal vitamin D on brain dopamine. In: T. J. Crow and S. R. Hirsch, Schizophrenia Research. XIIIth Biennial Winter Workshop on Schizophrenia Research, Davos, Switzerland, (204-205). 4-10 February 2006. doi:10.1016/j.schres.2006.01.006

  • Burne, T. H. J., Eyles, D. W., Kesby, J. P., Mackay-Sim, A. and McGrath, J. J. (2005). Behavioural outcomes of transient prenatal vitmain D deficiency in rats. In: P. Martin, Proceedings of 25th Annual Meeting of the Australian Neuroscience Society. 25th Annual Meeting of the Australian Neuroscience Society, Perth, Western Australia, (66-66). 30 January - 2 February 2005.

  • Burne, T, McGrath, J. J., Mackay-Sim, A. and Eyles, D. W. (2005). Developmental vitamin D deficiency and brain development: An informative animal mode of schizophrenia. In: P.Joyce, Abstracts for the Royal Australian and New Zealand College of Psychiatrists Joint CINP/ASPR Scientific Meeting. Joint CINP/ASPR Scientific Meeting, Brisbane Convention Centre, Brisbane, (A2-A2). 7-9 Dec..

  • Burne, T., Kesby, J. P., Feron, F., Eyles, D. W., Mackay-Sim, A. and McGrath, J. (2005). Maternal dietary manipulation alters brain structure and function in offspring: the effect of low maternal vitamin D. In: P. Martin, Proceedings 25th Annual Meeting of the Australian Neuroscience Society. 25th Annual Meeting of the Australian Neuroscience Society, Perth, Western Australia, (36-36). 3 January - 2 February.

  • Kesby, J. P., Burne, T, Ko,, McGrath, J and Eyles, D. W. (2005). Prenatal vitamin D3 deficiency produces selective locomotion abnormalities in adult offspring. In: P. Martin, Proceedings of the Australian Neuroscience Society. Australian Neuroscience Society, Perth, Western Australia, (118-118). 30 January - 2 February.

  • Harvey, L., McGrath, J. J. and Eyles, D. W. (2005). The Effects of vitmain D on NGF and GDNF production in primary glial cells. In: P. Martin, Proceedings of the Australian Neuroscience Society. , Perth, (67-67). 30 Jan. - 2 Feb..

  • Ko, P., Kesby, J. P., Burne, T, McGrath, J. J. and Eyles, D. W. (2005). The effects of low maternal vitamin D on brain dopamine. In: Proceedings of 25th Annual Meeting of the Australian Neuroscience Society. 25th Annual Meeting of the Australian Neuroscience Society, Perth, Western Australia, (66-66). January 30 - 2 February 2005.

  • Eyles, D., Kinobe, R., Smith, S., Hewison, M. and McGrath, J. (2004). The distribution of the vitamin D receptor and the enzyme responsible for it's synthesis in human brain. In: H. A. Nasrallah and L. E. Delisi, Schizophrenia Research. 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (119-119). 7-13 Feb 2004. doi:10.1016/j.schres.2003.10.001

  • Eyles, D., Burne, T., Brown, J., Smith, E., Mackay-Sim, A., McGrath, J. and Feron, F. (2004). Transient prenatal and early life hypovitaminosis D induce permanent alterations in brain morphology, cell density and gene expression consistent with alterations observed in schizophrenia. In: H. A. Nasrallah and L. E. Delisi, Schizophrenia Research. 12th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (119-120). 7-13 Feb 2004. doi:10.1016/j.schres.2003.10.001

  • McGrath, John J., Feron, François P., Burne, Thomas H. J., Mackay-Sim, Alan and Eyles, Darryl W. (2004). Vitamin D-3 - implications for brain development. In: R. Bouillon, A. W. Norman and J. R. Pasqualini, The Journal of Steroid Biochemistry and Molecular Biology: Proceedings of the 12th Workshop on Vitamin D. 12th Workshop on Vitamin D, Maastricht, The Netherlands, (557-560). 06-10 July 2003. doi:10.1016/j.jsbmb.2004.03.070

  • McGrath, J., Eyles, D., Feron, F., Mackay-Sim, A. and Lieberman, D. (2002). Disruption of pro-differentiating signals may underlie both loss of cerebral asymmetry and craniofacial features in schizophrenia. In: Abstract published in Schizophrenia Research. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (91-92). February 24–March 1, 2002. doi:10.1016/S0920-9964(01)00381-4

  • Mackay-Sim, A., Brown, J., Feron, F., Eyles, D. and McGrath, J. (2002). Low vitamin D disrupts pre-pulse inhibition in adult but not young rats: A new animal model of schizophrenia. In: Abstract published in Schizophrenia Research. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (216-216). 24 February - 1 March, 2002. doi:10.1016/S0920-9964(01)00381-4

  • Feron, F., Mackay-Sim, A., Eyles, D., Brown, J. and McGrath, J. (2002). Vitamin D depletion during development markedly alters gene expression in the adult rat brain: Gene array assessment of a novel risk factor for schizophrenia. In: Abstract published in Schizophrenia Research. XIth Biennial Winter Workshop on Schizophrenia, Davos, Switzerland, (83-83). 24 February - 1 March, 2002. doi:10.1016/S0920-9964(01)00381-4

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Master Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

Completed Supervision