Karnaker's research interests are natural products, peptide-based drug discovery and development, formulation chemistry and non-viral gene delivery system. Karnaker co-inventor and developed a novel, bioresponsive disulphide-linker technology, which has been used for non-viral vectors, peptide-therapeutics for pain and cancer treatment. Karnaker is also keen interest for topical, mucosal drug delivery using a range of dendrimer, nano and microbubbles, lipid and polymer-based nanoparticle systems in conjugation with both biological and physical stimuli-responsiveness.
Karnaker received a PhD in Pharmaceutical Chemistry from The University Queensland under the supervision of Dr Harendra Parekh and Dr Defang Ouyang. Prior to PhD, he completed a Master degree in Pharmaceutical Analysis and Quality assurance (India). Also worked as analytical research and development chemist for one year in a Pharma company. Since 2016, he his working with Dr Parekh team on a range of Industry-funded research projects and his role involves from ideation, research plan, execution, product delivery to industry partners on major platforms such as peptide-based therapeutics, gene therapy and sol-gel technology.
Karnaker is co-inventor for several patents (PCT, provisional stage) from Dr Parekh and Team, licensed to industry partners which received million dollars in funding for further research and development
Journal Article: Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy
Lohman, Rink-Jan, Reddy Tupally, Karnaker, Kandale, Ajit, Cabot, Peter J. and Parekh, Harendra S. (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1-16. doi: 10.3389/fphar.2023.1150313
Journal Article: A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic
Rad, Isaac J., Chapman, Luke, Tupally, Karnaker Reddy, Veidt, Martin, Al-Sadiq, Hussain, Sullivan, Robert and Parekh, Harendra S (2023). A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic. Theranostics, 13 (11), 3582-3638. doi: 10.7150/thno.82884
Journal Article: Multi-physics study of acoustofluidic delivery agents' clustering behavior
AlSadiq, Hussain, Tupally, Karnaker Reddy, Vogel, Robert, Parekh, Harendra S. and Veidt, Martin (2022). Multi-physics study of acoustofluidic delivery agents' clustering behavior. Physics in Medicine and Biology, 67 (1) 015002, 015002. doi: 10.1088/1361-6560/ac4666
the role of TLR4 in the effect of opioids on tumour growth and metastasis
Doctor Philosophy
Gel-based drug delivery monitored via medical imaging
Doctor Philosophy
The pharmacological evaluation of beta-endorphin analogues: opioid-based bivalent peptide DB1-7 targeting multiple opioid receptors.
Doctor Philosophy
Therapeutic perspectives in Type-1 Diabetes
Singh, Prachi, Kokil, Ganesh R., Tupally, Karnaker R., Poddar, Kingshuk, Tan, Aaron, Venkatesan, Venky, Parekh, Harendra S. and Pastorin, Giorgia (2016). Therapeutic perspectives in Type-1 Diabetes. Singapore: Springer. doi: 10.1007/978-981-10-0602-9
Introduction to diabetes and type 1 diabetes
Singh, Prachi, Kokil, Ganesh R., Tupally, Karnaker R., Poddar, Kingshuk, Tan, Aaron, Venkatesan, Venky, Parekh, Harendra S. and Pastorin, Giorgia (2016). Introduction to diabetes and type 1 diabetes. Therapeutic perspectives in type-1 diabetes. (pp. 1-6) edited by Prachi Singh, Ganesh R. Kokil, Karnaker R. Tupally, Kingshuk Poddar, Aaron Tan, Venky Venkatesan, Harendra S. Parekh and Giorgia Pastorin. Singapore, Singapore: Springer. doi: 10.1007/978-981-10-0602-9_1
Tupally, Karnaker R., Kokil, Ganesh K., Thakur, Sachin S., Singh, Prachi and Parekh, Harendra S. (2015). Dendrimers. Controlled release systems: advances in nanobottles and active nanoparticles. (pp. 259-286) edited by Alexander van Herk, Jacqueline Forcada and Giorgia Pastorin. Boca Raton, FL, United States: Taylor & Francis. doi: 10.1201/b19860-15
Fluorescent nucleic acid probes in living cells
Seefeld, Anne, Kokil, Ganesh R., Tupally, Karnaker R., Parekh, Harendra S. and Herten, Dirk-Peter (2013). Fluorescent nucleic acid probes in living cells. DNA and RNA nanobiotechnologies in medicine: diagnosis and treatment of diseases. (pp. 291-328) edited by Volker A. Erdmann and Jan Barciszewski. Berlin, Germany: Springer. doi: 10.1007/978-3-642-36853-0_12
Lohman, Rink-Jan, Reddy Tupally, Karnaker, Kandale, Ajit, Cabot, Peter J. and Parekh, Harendra S. (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1-16. doi: 10.3389/fphar.2023.1150313
Rad, Isaac J., Chapman, Luke, Tupally, Karnaker Reddy, Veidt, Martin, Al-Sadiq, Hussain, Sullivan, Robert and Parekh, Harendra S (2023). A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic. Theranostics, 13 (11), 3582-3638. doi: 10.7150/thno.82884
Multi-physics study of acoustofluidic delivery agents' clustering behavior
AlSadiq, Hussain, Tupally, Karnaker Reddy, Vogel, Robert, Parekh, Harendra S. and Veidt, Martin (2022). Multi-physics study of acoustofluidic delivery agents' clustering behavior. Physics in Medicine and Biology, 67 (1) 015002, 015002. doi: 10.1088/1361-6560/ac4666
Shell properties and concentration stability of acoustofluidic delivery agents
Alsadiq, Hussain, Tupally, Karnaker, Vogel, Robert, Kokil, Ganesh, Parekh, Harendra S. and Veidt, Martin (2021). Shell properties and concentration stability of acoustofluidic delivery agents. Physical and Engineering Sciences in Medicine, 44 (1), 79-91. doi: 10.1007/s13246-020-00954-4
Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds
Alsenani, Faisal, Tupally, Karnaker R., Chua, Elvis T., Eltanahy, Eladl, Alsufyani, Hamed, Parekh, Harendra S. and Schenk, Peer M. (2020). Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds. Saudi Pharmaceutical Journal, 28 (12), 1834-1841. doi: 10.1016/j.jsps.2020.11.010
de Luca, Sergio, Seal, Prasenjit, Parekh, Harendra S., Tupally, Karnaker R. and Smith, Sean C. (2020). Cell membrane penetration without pore formation: chameleonic properties of dendrimers in response to hydrophobic and hydrophilic environments. Advanced Theory and Simulations, 3 (7) 1900152, 1900152. doi: 10.1002/adts.201900152
Jing, Jing, Tupally, Karnaker R., Kokil, Ganesh R., Qu, Zhi, Chen, Sibao and Parekh, Harendra S. (2019). Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine. RSC Advances, 9 (5), 2458-2463. doi: 10.1039/c8ra09606f
Shetty, Pallavi Krishna, Manikkath, Jyothsna, Tupally, Karnaker, Kokil, Ganesh, Hegde, Aswathi R., Raut, Sushil Y., Parekh, Harendra S. and Mutalik, Srinivas (2017). Skin delivery of EGCG and silibinin: potential of peptide dendrimers for enhanced skin permeation and deposition. AAPS PharmSciTech, 18 (6), 2346-2357. doi: 10.1208/s12249-017-0718-0
Hegde, Aswathi R., Rewatkar, Prarthana V., Manikkath, Jyothsna, Tupally, Karnaker, Parekh, Harendra S. and Mutalik, Srinivas (2017). Peptide dendrimer-conjugates of ketoprofen: synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery. European Journal of Pharmaceutical Sciences, 102, 237-249. doi: 10.1016/j.ejps.2017.03.009
Shell properties of a new acoustofluidic delivery agent
AL-Sadiq, H. A., Tupally, K. R., Parekh, H S. and M Veidt, M. (2021). Shell properties of a new acoustofluidic delivery agent. EPSM 2020, Engineering and Physical Sciences in Medicine, Brisbane, QLD Australia, 28-29 October 2020. Dordrecht, Netherlands: Springer Netherlands.
Alsadiq, H., Tupally, K. R., Kokil, G. R., Vogel, R., Parekh, H. S. and Veidt, M. (2019). Concentration stability of monolayer and bilayer lipid microbubbles–a precursor for new drug delivery applications. Drug Delivery Australia 2019 Conference, Brisbane, QLD Australia, 18-19 November 2019.
Influence of acoustofluidic parameters on velocity streaming of sonicated medical microbubbles
Alsadiq, Hussain, Reddy, Karnaker, Parekh, Harendra and Veidt, Martin (2018). Influence of acoustofluidic parameters on velocity streaming of sonicated medical microbubbles. AAS2018: Acoustics 2018: Hear to Listen, Adelaide, SA Australia, 6-9 November 2018. Adelaide, SA Australia: Australian Acoustical Society.
the role of TLR4 in the effect of opioids on tumour growth and metastasis
Doctor Philosophy — Associate Advisor
Other advisors:
Gel-based drug delivery monitored via medical imaging
Doctor Philosophy — Associate Advisor
Other advisors:
The pharmacological evaluation of beta-endorphin analogues: opioid-based bivalent peptide DB1-7 targeting multiple opioid receptors.
Doctor Philosophy — Associate Advisor
Other advisors:
Harnessing ultrasound for therapeutic delivery - a proof-of-concept approach
Doctor Philosophy — Associate Advisor
Other advisors:
Chimeric Opioid Peptides as a allosteric modulators of nociception
Doctor Philosophy — Associate Advisor
Other advisors:
IDENTIFICATION AND INDUCED BIOSYNTHESIS OF NATURAL HEALTH COMPOUNDS IN MICROALGAE
(2019) Doctor Philosophy — Associate Advisor
Other advisors: