Professor Michael Pender

Professor

Royal Brisbane Clinical Unit
Faculty of Medicine
m.pender@uq.edu.au
+61 7 336 55132

Overview

Professor Michael Pender graduated from The University of Queensland in 1974 with First Class Honours in Medicine and a University Medal. Over the next six years he trained as a physician and neurologist at the Royal Prince Alfred Hospital and St Vincent's Hospital, Sydney, and became a Fellow of the Royal Australasian College of Physicians (FRACP) in 1981. During his specialist clinical training he developed a keen interest in multiple sclerosis which he has continued since then. After completing his clinical training in neurology, he was a research scholar in the field of multiple sclerosis at the Institute of Neurology, Queen Square, London, and was awarded a PhD from the University of London and Queen Square Prize for Research in 1983. From 1984–1986 he continued this research as a Research Fellow at the John Curtin School of Medical Research, Australian National University, Canberra. In 1987 he was appointed Senior Lecturer in the Department of Medicine, The University of Queensland, at the Royal Brisbane Hospital. In 1989 he was awarded a Doctorate of Medicine from The University of Queensland for his research in the field of multiple sclerosis and was promoted to Reader in Medicine. In 1995 he was promoted to Professor of Medicine (Personal Chair), The University of Queensland. His main clinical and research interest is multiple sclerosis. He also held the positions of Director of Neurology, Royal Brisbane and Women's Hospital, from 1992–2005, Director of the Neuroimmunology Research Centre, The University of Queensland, from 1991–2007 and Director of the Multiple Sclerosis Research Centre, The University of Queensland, from 2009–2014. In 1996, with the support of the Multiple Sclerosis Society of Queensland, he established a Multiple Sclerosis Clinic at the Royal Brisbane and Women's Hospital, which he has directed since then. He is also an Honorary Senior Principal Research Fellow at the QIMR Berghofer Medical Research Institute. In 2006 he was awarded the Multiple Sclerosis Australia Prize for Multiple Sclerosis Research - 'For outstanding commitment and dedication to research into the cause and cure of Multiple Sclerosis in Australia'. In 2011 he received the John H Tyrer Prize in Internal Medicine, The University of Queensland, for research in the field of Internal Medicine. He was the Sir Raphael Cilento Orator of the Royal Australasian College of Medical Administrators for 2009 and the W Ian McDonald Lecturer of the Australian and New Zealand Association of Neurologists for 2014. Major research achievements include: the discovery of apoptosis of autoreactive T cells in the central nervous system as a fundamental mechanism of recovery from autoimmune attack (Journal of the Neurological Sciences 1991, Journal of Autoimmunity 1992, European Journal of Immunology 1994); formulation of a novel hypothesis (The Lancet 1998) proposing a failure of this mechanism in multiple sclerosis; and the further development of this hypothesis into a new paradigm (Trends in Immunology 2003) for the cause of human chronic autoimmune diseases based on infection of autoreactive B cells with the Epstein–Barr virus, some of the predictions of which have already been verified in multiple sclerosis, rheumatoid arthritis and Sjögren’s syndrome.

PUBLICATIONS: https://medicine.uq.edu.au/ms-research-group-publications

Qualifications

  • MD, The University of Queensland
  • Doctor of Philosophy, University of London
  • FRACP
  • MBBS (Honours1), The University of Queensland

Publications

  • Bukhari, Wajih, Prain, Kerri M., Waters, Patrick, Woodhall, Mark, O'Gorman, Cullen M., Clarke, Laura, Silvestrini, Roger A., Bundell, Christine S., Abernethy, David, Bhuta, Sandeep, Blum, Stefan, Boggild, Mike, Boundy, Karyn, Brew, Bruce J., Brown, Matthew, Brownlee, Wallace J., Butzkueven, Helmut, Carroll, William M., Chen, Celia, Coulthard, Alan, Dale, Russell C., Das, Chandi, Dear, Keith, Fabis-Pedrini, Marzena J., Fulcher, David, Gillis, David, Hawke, Simon, Heard, Robert, Henderson, Andrew P. D., Heshmat, Saman, Hodgkinson, Suzanne, Jimenez-Sanchez, Sofia, Killpatrick, Trevor, King, John, Kneebone, Christopher, Kornberg, Andrew J., Lechner-Scott, Jeannette, Lin, Ming-Wei, Lynch, Christpher, Macdonell, Richard, Mason, Deborah F., McCombe, Pamela A., Pender, Michael P., Pereira, Jennifer A., Pollard, John D., Reddel, Stephen W., Shaw, Cameron, Spies, Judith, Stankovich, James, Sutton, Ian, Vucic, Steve, Walsh, Michael, Wong, Richard C., Yiu, Eppie M., Barnett, Michael H., Kermode, Allan G., Marriott, Mark P., Parratt, John D. E., Slee, Mark, Taylor, Bruce V., Willoughby, Ernest, Wilson, Robert J., Vincent, Angela and Broadley, Simon A. (2017) Incidence and prevalence of NMOSD in Australia and New Zealand. Journal of Neurology Neurosurgery and Psychiatry, 88 8: 632-638. doi:10.1136/jnnp-2016-314839

  • Saul, Alice, Ponsonby, Anne-Louise, Lucas, Robyn M., Taylor, Bruce V., Simpson, Steve, Jr., Valery, Patricia, Dwyer, Terence, Kilpatrick, Trevor J., Pender, Michael P. and van der Mei, Ingrid A. F. (2017) Stressful life events and the risk of initial central nervous system demyelination. Multiple Sclerosis Journal, 23 7: 1000-1007. doi:10.1177/1352458516667566

  • Greer, Judith M., Broadley, Simon and Pender, Michael P. (2017) Reactivity to novel autoantigens in patients with coexisting central nervous system demyelinating disease and autoimmune thyroid disease. Frontiers in Immunology, 8 514: 514-514. doi:10.3389/fimmu.2017.00514

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

  • Pender, Michael P. (2004). Epstein-Barr Virus and Autoimmunity. In Shoenfeld, Yehuda and Rose, Noel R. (Ed.), Infection and Autoimmunity (pp. 163-170) Amsterdam: Elsevier.

  • Pender, Michael P. (1996). Immunopathology and Pathophysiology of Experimental Autoimmune Encephalomyelitis. In Bostock, H., Kirkwood, P. A. and Pullen, A. H. (Ed.), The Neurobiology of Disease: Contributions from Neuroscience to Clinical Neurology (pp. 75-85) Cambridge, UK: Cambridge University Press.

  • Pender, Michael P. (1995). Acute Disseminated Encephalomyelitis. In Pender, Michael P. and McCombe, Pamela A. (Ed.), Autoimmune Neurological Disease (pp. 155-165) Cambridge, UK: Cambridge University Press.

  • Pender, Michael P. (1995). An Introduction to Neuroimmunology. In Pender, Michael P. and McCombe, Pamela A. (Ed.), Autoimmune Neurological Disease (pp. 14-25) Cambridge, UK: Cambridge University Press.

  • Pender, Michael P. (1995). Experimental Autoimmune Encephalomyelitis. In Pender, Michael P. and McCombe, Pamela A. (Ed.), Autoimmune Neurological Disease (pp. 26-88) Cambridge, UK: Cambridge University Press.

  • Pender, Michael P. (1995). Multiple Sclerosis. In Pender, Michael P. and McCombe, Pamela A. (Ed.), Autoimmune Neurological Disease (pp. 89-154) Cambridge, UK: Cambridge University Press.

  • Pender, Michael P. (1995). Paraneoplastic Neurological Disorders. In Pender, Michael P. and McCombe, Pamela A. (Ed.), Autoimmune Neurological Disease (pp. 327-344) Cambridge, UK: Cambridge University Press.

  • Pender, Michael P. (1995). The Stiff-Man Syndrome. In Pender, Michael P. and McCombe, Pamela A. (Ed.), Autoimmune Neurological Disease (pp. 166-176) Cambridge, UK: Cambridge University Press.

Journal Article

Conference Publication

Edited Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Completed Supervision