The University of Queensland

Journal Article

• In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2

  Emanuel, Jackson, Papies, Jan, Galander, Celine, Adler, Julia M, Heinemann, Nicolas, Eschke, Kathrin, Merz, Sophie, Pischon, Hannah, Rose, Ruben, Krumbholz, Andi, Kulić, Žarko, Lehner, Martin D, Trimpert, Jakob and Müller, Marcel A (2023). In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2. Frontiers in Pharmacology, 14 1214351, 1-17. doi: 10.3389/fphar.2023.1214351

• Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

  Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366

• Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron

  Kreye, Jakob, Reincke, S. Momsen, Edelburg, Stefan, Jeworowski, Lara M., Kornau, Hans-Christian, Trimpert, Jakob, Hombach, Peter, Halbe, Sophia, Noelle, Volker, Meyer, Martin, Kattenbach, Stefanie, Sanchez-Sendin, Elisa, Schmidt, Marie L., Schwarz, Tatjana, Rose, Ruben, Krumbholz, Andi, Merz, Sophie, Adler, Julia M., Eschke, Kathrin, Abdelgawad, Azza, Schmitz, Dietmar, Sander, Leif E., Janssen, Uwe, Corman, Victor M. and Pruess, Harald (2023). Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron. iScience, 26 (4) 106323, 1-22. doi: 10.1016/j.isci.2023.106323

• The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

  Rothenberger, Sylvia, Hurdiss, Daniel L., Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloe, Calabro, Valerie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel ... Trimpert, Jakob (2022). The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants. Nature Biotechnology, 40 (12), 1845-1854 . doi: 10.1038/s41587-022-01382-3

• Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication

  Los, Bruna, Preussner, Marco, Eschke, Kathrin, Vidal, Ricardo Martin, Abdelgawad, Azza, Olofsson, Didrik, Keiper, Sandra, Paulo-Pedro, Margarida, Grindel, Alica, Meinke, Stefan, Trimpert, Jakob and Heyd, Florian (2022). Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication. Nucleic Acids Research, 50 (12), 6769-6785. doi: 10.1093/nar/gkac513

• Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics

  Wyler, Emanuel, Adler, Julia M., Eschke, Kathrin, Teixeira Alves, G., Peidli, Stefan, Pott, Fabian, Kazmierski, Julia, Michalick, Laura, Kershaw, Olivia, Bushe, Judith, Andreotti, Sandro, Pennitz, Peter, Abdelgawad, Azza, Postmus, Dylan, Goffinet, Christine, Kreye, Jakob, Reincke, S. Momsen, Prüss, Harald, Blüthgen, Nils, Gruber, Achim D., Kuebler, Wolfgang M., Witzenrath, Martin, Landthaler, Markus, Nouailles, Geraldine and Trimpert, Jakob (2022). Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics. Molecular Therapy, 30 (5), 1952-1965. doi: 10.1016/j.ymthe.2022.03.014

• Rapid SARS-CoV-2 adaptation to available cellular proteases

  Chaudhry, M. Zeeshan, Eschke, Kathrin, Hoffmann, Markus, Grashoff, Martina, Abassi, Leila, Kim, Yeonsu, Brunotte, Linda, Ludwig, Stephan, Kröger, Andrea, Klawonn, Frank, Pöhlmann, Stefan H. and Cicin-Sain, Luka (2022). Rapid SARS-CoV-2 adaptation to available cellular proteases. Journal of Virology, 96 (5) e0218621, 1-17. doi: 10.1128/jvi.02186-21

• MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

  Kim, Yeonsu, Zheng, Xiaoyan, Eschke, Kathrin, Chaudhry, M. Zeeshan, Bertoglio, Federico, Tomić, Adriana, Krmpotić, Astrid, Hoffmann, Markus, Bar-On, Yotam, Boehme, Julia, Bruder, Dunja, Ebensen, Thomas, Brunotte, Linda, Ludwig, Stephan, Messerle, Martin, Guzman, Carlos, Mandelboim, Ofer, Hust, Michael, Pöhlmann, Stefan, Jonjić, Stipan and Čičin-Šain, Luka (2022). MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination. Cellular and Molecular Immunology, 19 (2), 234-244. doi: 10.1038/s41423-021-00814-5

• Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)

  Trimpert, Jakob, Adler, Julia M, Eschke, Kathrin, Abdelgawad, Azza, Firsching, Theresa C, Ebert, Nadine, Thao, Tran Thi Nhu, Gruber, Achim D, Thiel, Volker, Osterrieder, Nikolaus and Kunec, Dusan (2021). Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta). Science Advances, 7 (49) eabk0172, eabk0172. doi: 10.1126/sciadv.abk0172

• Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies

  Pommerenke, Claudia, Rand, Ulfert, Uphoff, Cord C., Nagel, Stefan, Zaborski, Margarete, Hauer, Vivien, Kaufmann, Maren, Meyer, Corinna, Denkmann, Sabine A., Riese, Peggy, Eschke, Kathrin, Kim, Yeonsu, Safranko, Zeljka Macak, Kurolt, Ivan-Christian, Markotic, Alemka, Cicin-Sain, Luka and Steenpass, Laura (2021). Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies. PloS one, 16 (8) e0255622, e0255622. doi: 10.1371/journal.pone.0255622

• A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations

  Bertoglio, Federico, Fühner, Viola, Ruschig, Maximilian, Heine, Philip Alexander, Abassi, Leila, Klünemann, Thomas, Rand, Ulfert, Meier, Doris, Langreder, Nora, Steinke, Stephan, Ballmann, Rico, Schneider, Kai-Thomas, Roth, Kristian Daniel Ralph, Kuhn, Philipp, Riese, Peggy, Schäckermann, Dorina, Korn, Janin, Koch, Allan, Chaudhry, M Zeeshan, Eschke, Kathrin, Kim, Yeonsu, Zock-Emmenthal, Susanne, Becker, Marlies, Scholz, Margitta, Moreira, Gustavo Marçal Schmidt Garcia, Wenzel, Esther Veronika, Russo, Giulio, Garritsen, Hendrikus S P, Casu, Sebastian ... Hust, Michael (2021). A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations. Cell Reports, 36 (4) 109433, 1-23. doi: 10.1016/j.celrep.2021.109433

• Equine herpesvirus type 4 (EHV-4) outbreak in Germany: virological, serological, and molecular investigations

  Pavulraj, Selvaraj, Eschke, Kathrin, Theisen, Jana, Westhoff, Stephanie, Reimers, Gitta, Andreotti, Sandro, Osterrieder, Nikolaus and Azab, Walid (2021). Equine herpesvirus type 4 (EHV-4) outbreak in Germany: virological, serological, and molecular investigations. Pathogens, 10 (7), 810. doi: 10.3390/pathogens10070810

• SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

  Bertoglio, Federico, Meier, Doris, Langreder, Nora, Steinke, Stephan, Rand, Ulfert, Simonelli, Luca, Heine, Philip Alexander, Ballmann, Rico, Schneider, Kai-Thomas, Roth, Kristian Daniel Ralph, Ruschig, Maximilian, Riese, Peggy, Eschke, Kathrin, Kim, Yeonsu, Schäckermann, Dorina, Pedotti, Mattia, Kuhn, Philipp, Zock-Emmenthal, Susanne, Wöhrle, Johannes, Kilb, Normann, Herz, Tobias, Becker, Marlies, Grasshoff, Martina, Wenzel, Esther Veronika, Russo, Giulio, Kröger, Andrea, Brunotte, Linda, Ludwig, Stephan, Fühner, Viola ... Hust, Michael (2021). SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. Nature Communications, 12 (1) 1577. doi: 10.1038/s41467-021-21609-2

• Bearing the brunt: Mongolian khulan (Equus hemionus hemionus) are exposed to multiple influenza A strains

  Soilemetzidou, Eirini S., de Bruin, Erwin, Eschke, Kathrin, Azab, Walid, Osterrieder, Nikolaus, Czirjak, Gabor A., Buuveibaatar, Bayarbaatar, Kaczensky, Petra, Koopmans, Marion, Walzer, Chris and Greenwood, Alex D. (2020). Bearing the brunt: Mongolian khulan (Equus hemionus hemionus) are exposed to multiple influenza A strains. Veterinary Microbiology, 242 108605. doi: 10.1016/j.vetmic.2020.108605

• A proofreading-impaired herpesvirus generates populations with quasispecies-like structure

  Trimpert, Jakob, Groenke, Nicole, Kunec, Dusan, Eschke, Kathrin, He, Shulin, McMahon, Dino P. and Osterrieder, Nikolaus (2019). A proofreading-impaired herpesvirus generates populations with quasispecies-like structure. Nature Microbiology, 4 (12), 2175-2183. doi: 10.1038/s41564-019-0547-x

• A proofreading-impaired herpesvirus generates populations with quasispecies-like structure (vol 4, pg 2025, 2019)

  Trimpert, Jakob, Groenke, Nicole, Kunec, Dusan, Eschke, Kathrin, He, Shulin, McMahon, Dino P. and Osterrieder, Nikolaus (2019). A proofreading-impaired herpesvirus generates populations with quasispecies-like structure (vol 4, pg 2025, 2019). Nature Microbiology, 4 (11), 2025-2025. doi: 10.1038/s41564-019-0598-z

• Fatal elephant endotheliotropic herpesvirus infection of two young Asian elephants

  Pavulraj, Selvaraj, Eschke, Kathrin, Prahl, Adriane, Flügger, Michael, Trimpert, Jakob, van den Doel, Petra B., Andreotti, Sandro, Kaessmeyer, Sabine, Osterrieder, Nikolaus and Azab, Walid (2019). Fatal elephant endotheliotropic herpesvirus infection of two young Asian elephants. Microorganisms, 7 (10), 396. doi: 10.3390/microorganisms7100396

• Detection of equid herpesviruses among different Arabian horse populations in Egypt

  Azab, Walid, Bedair, Sameh, Abdelgawad, Azza, Eschke, Kathrin, Farag, Gemelat K., Abdel-Raheim, Ali, Greenwood, Alex D., Osterrieder, Nikolaus and Ali, Ahmed A. H. (2019). Detection of equid herpesviruses among different Arabian horse populations in Egypt. Veterinary Medicine and Science, 5 (3), 361-371. doi: 10.1002/vms3.176

• Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization

  Eschke, Kathrin, Trimpert, Jakob, Osterrieder, Nikolaus and Kunec, Dusan (2018). Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization. PLoS Pathogens, 14 (1), e1006857. doi: 10.1371/journal.ppat.1006857

• Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S-M interaction

  Gelhaus, Sandra, Thaa, Bastian, Eschke, Kathrin, Veit, Michael and Schwegmann-Weßels, Christel (2014). Palmitoylation of the Alphacoronavirus TGEV spike protein S is essential for incorporation into virus-like particles but dispensable for S-M interaction. Virology, 464-465, 397-405. doi: 10.1016/j.virol.2014.07.035