In 2018 Dr. Amelia Soderholm was awarded a PhD in the fields of immunology and microbiology for her research under the supervision of Professor Mark Walker at the University of Queensland, Australia. Her PhD research investigated the interaction of Group A Streptococcus with innate immune signalling pathways, specifically during infection of human tonsil epithelial cells. During this time, she became interested in the role epithelial cells play in host immunity during health and disease. In 2019 Dr. Soderholm subsequently embarked on post-doctoral training with Dr. Virginia Pedicord at the University of Cambridge, UK, where her research focused on characterising the cross talk between the gut microbiome, intestinal epithelial cells, and intestinal T cell populations. Dr. Soderholm was particularly interested in what microbial and epithelial factors influence the development of CD4+CD8αα+ intraepithelial T cells, an elusive T cell population found in the small intestine. From this work she developed a strong interest in the factors that shape T cell development and function. In 2023 Dr. Soderholm returned to the University of Queensland to pursue my interest in T cells but in the context of skin cancer, under the mentorship of Associate Professor James Wells. Dr. Soderholm's research journey has equipped her with a solid foundation in T cell immunology, epithelial biology, and microbiology, along with an appreciation of the complexities of our immune system. Her career goal is to push the present boundaries of knowledge in the field of skin and mucosal immunology, utilising my skills to make meaningful research contributions to the field that can be ultimately translated into clinical applications.
Conference Publication: The Toll-like receptor 4 pathway modulates response to anti-PD-1 therapy
Whiteside, Sarah K., Beresford-Jones, Benjamin S., Sadar, Puspendu, Kuo, Paula, Xia, Wangmingyu, Suyama, Satoshi, Evans, Alexander C., Imianowski, Charlotte J., Conti, Alberto G., Wesolowski, Alexander J., Soderholm, Amelia, Tourlomousis, Panagiotis, Okkenhaug, Klaus, Bryant, Clare E., Pedicord, Virginia and Roychoudhuri, Rahul (2023). The Toll-like receptor 4 pathway modulates response to anti-PD-1 therapy. IMMUNOLOGY 2023™ Meeting, Washington, DC, United States, 11 - 15 May 2023. Rockville, MD, United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.172.19
Journal Article: Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis
Forster, Samuel C., Clare, Simon, Beresford-Jones, Benjamin S., Harcourt, Katherine, Notley, George, Stares, Mark D., Kumar, Nitin, Soderholm, Amelia T., Adoum, Anne, Wong, Hannah, Moron, Belen, Brandt, Cordelia, Dougan, Gordon, Adams, David J., Maloy, Kevin J., Pedicord, Virginia A. and Lawley, Trevor D. (2022). Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis. Nature Microbiology, 7 (4), 590-599. doi: 10.1038/s41564-022-01094-z
Journal Article: The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping
Beresford-Jones, Benjamin S., Forster, Samuel C., Stares, Mark D., Notley, George, Viciani, Elisa, Browne, Hilary P., Boehmler, Daniel J., Soderholm, Amelia T., Kumar, Nitin, Vervier, Kevin, Cross, Justin R., Almeida, Alexandre, Lawley, Trevor D. and Pedicord, Virginia A. (2022). The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping. Cell Host & Microbe, 30 (1), 124-138.e8. doi: 10.1016/j.chom.2021.12.003
Localised immune checkpoint therapy for cutaneous head and neck cancer
(2024–2026) TRI Leading Innovations through New Collaborations Scheme
Defining principles of T cell-mediated melanoma rejection
Doctor Philosophy
Forster, Samuel C., Clare, Simon, Beresford-Jones, Benjamin S., Harcourt, Katherine, Notley, George, Stares, Mark D., Kumar, Nitin, Soderholm, Amelia T., Adoum, Anne, Wong, Hannah, Moron, Belen, Brandt, Cordelia, Dougan, Gordon, Adams, David J., Maloy, Kevin J., Pedicord, Virginia A. and Lawley, Trevor D. (2022). Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis. Nature Microbiology, 7 (4), 590-599. doi: 10.1038/s41564-022-01094-z
Beresford-Jones, Benjamin S., Forster, Samuel C., Stares, Mark D., Notley, George, Viciani, Elisa, Browne, Hilary P., Boehmler, Daniel J., Soderholm, Amelia T., Kumar, Nitin, Vervier, Kevin, Cross, Justin R., Almeida, Alexandre, Lawley, Trevor D. and Pedicord, Virginia A. (2022). The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping. Cell Host & Microbe, 30 (1), 124-138.e8. doi: 10.1016/j.chom.2021.12.003
Ventilator-associated pneumonia in critically ill patients with COVID-19 (vol 25, 25, 2021)
Maes, Mailis, Higginson, Ellen, Pereira-Dias, Joana, Curran, Martin D., Parmar, Surendra, Khokhar, Fahad, Cuchet-Lourenco, Delphine, Lux, Janine, Sharma-Hajela, Sapna, Ravenhill, Benjamin, Hamed, Islam, Heales, Laura, Mahroof, Razeen, Soderholm, Amelia, Forrest, Sally, Sridhar, Sushmita, Brown, Nicholas M., Baker, Stephen, Navapurkar, Vilas, Dougan, Gordon, Scott, Josefn Bartholdson and Morris, Andrew Conway (2021). Ventilator-associated pneumonia in critically ill patients with COVID-19 (vol 25, 25, 2021). Critical Care, 25 (1) 130. doi: 10.1186/s13054-021-03560-2
A specific microbial metabolite influences the development of peripheral intraepithelial lymphocytes
Soderholm, Amelia T., Beresford-Jones, Benjamin, Clare, Simon and Pedicord, Virginia Ahn (2020). A specific microbial metabolite influences the development of peripheral intraepithelial lymphocytes. The Journal of Immunology, 204 (1_Supplement), 230.2-230.2. doi: 10.4049/jimmunol.204.supp.230.2
Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity
Soderholm, Amelia T. and Pedicord, Virginia A. (2019). Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity. Immunology, 158 (4), 267-280. doi: 10.1111/imm.13117
Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance
Bohlmann, Lisa, De Oliveira, David M. P., El-Deeb, Ibrahim M., Brazel, Erin B., Harbison-Price, Nichaela, Ong, Cheryl-lynn Y., Rivera-Hernandez, Tania, Ferguson, Scott A., Cork, Amanda J., Phan, Minh-Duy, Soderholm, Amelia T., Davies, Mark R., Nimmo, Graeme R., Dougan, Gordon, Schembri, Mark A., Cook, Gregory M., McEwan, Alastair G., von Itzstein, Mark, McDevitt, Christopher A. and Walker, Mark J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9 (6) e02391-18, 1-12. doi: 10.1128/mBio.02391-18
A host proteome atlas of Streptococcus pyogenes infection
Soderholm, Amelia T. and Walker, Mark J. (2018). A host proteome atlas of Streptococcus pyogenes infection. Cell Systems, 6 (5), 536-538. doi: 10.1016/j.cels.2018.05.003
Soderholm, Amelia T., Barnett, Timothy C., Korn, Othmar, Rivera-Hernandez, Tania, Seymour, Lisa M., Schulz, Benjamin L., Nizet, Victor, Wells, Christine A., Sweet, Matthew J. and Walker, Mark J. (2018). Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP. Frontiers in Cellular and Infection Microbiology, 8 (MAY) 160, 160. doi: 10.3389/fcimb.2018.00160
Soderholm, Amelia T., Barnett, Timothy C., Sweet, Matthew J. and Walker, Mark J. (2017). Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies. Journal of Leukocyte Biology, 103 (2), 193-213. doi: 10.1189/jlb.4MR0617-227RR
Host-pathogen interaction during bacterial vaccination
Barnett, Timothy C., Lim, Jin Yan, Soderholm, Amelia T., Rivera-Hernandez, Tania, West, Nicholas P. and Walker, Mark J. (2015). Host-pathogen interaction during bacterial vaccination. Current Opinion in Immunology, 36, 1-7. doi: 10.1016/j.coi.2015.04.002
Yang, Zhe, Soderholm, Amelia, Lung, Tania Wong Fok, Giogha, Cristina, Hill, Michelle M., Brown, Nathaniel F., Hartland, Elizabeth and Teasdale, Rohan D. (2015). SseK3 is a salmonella effector that binds trim32 and modulates the host's nf-kappa b signalling activity. PL o S One, 10 (9) e0138529, 1-20. doi: 10.1371/journal.pone.0138529
The Toll-like receptor 4 pathway modulates response to anti-PD-1 therapy
Whiteside, Sarah K., Beresford-Jones, Benjamin S., Sadar, Puspendu, Kuo, Paula, Xia, Wangmingyu, Suyama, Satoshi, Evans, Alexander C., Imianowski, Charlotte J., Conti, Alberto G., Wesolowski, Alexander J., Soderholm, Amelia, Tourlomousis, Panagiotis, Okkenhaug, Klaus, Bryant, Clare E., Pedicord, Virginia and Roychoudhuri, Rahul (2023). The Toll-like receptor 4 pathway modulates response to anti-PD-1 therapy. IMMUNOLOGY 2023™ Meeting, Washington, DC, United States, 11 - 15 May 2023. Rockville, MD, United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.172.19
Soderholm, Amelia T., Beresford-Jones, Benjamin, Clare, Simon and Pedicord, Virginia Ahn (2021). The development of peripheral intraepithelial lymphocytes in vivo is influenced by microbial metabolites. Immunology 2021™ Meeting, Virtual, 10 - 15 May 2021. Rockville, MD, United States: American Association of Immunologists. doi: 10.4049/jimmunol.206.Supp.100.10
Soderholm, Amelia (2018). The Group A Streptococcus M1T1 clone post-transcriptionally modifies innate immune signalling to promote infection. PhD Thesis, School of Chemistry and Molecular Biosciences, The University of Queensland. doi: 10.14264/uql.2018.640
Localised immune checkpoint therapy for cutaneous head and neck cancer
(2024–2026) TRI Leading Innovations through New Collaborations Scheme
Defining principles of T cell-mediated melanoma rejection
Doctor Philosophy — Associate Advisor
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