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Development of novel therapeutics for melanoma and non-melanoma cancer… Hypoxia-induced stress responses in cancer and cancer stem cells… Skin Cancer… ) promotes stress and death of the organism. However, cancer cells have evolved adaptive mechanisms to…
Researcher Biography
Dr Snehlata Kumari is the head of skin inflammation and immunity laboratory at the Frazer Institute, the University of Queensland in Brisbane, Australia. She is a board member of the Australasian Society for Dermatology Research (ASDR).
After PhD and post-doctoral training in …
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extracellular vesicles by the placenta during gestation, and tumour cells in ovarian cancer… Hypoxia increases the exosome release from ovarian cancer cells and promotes the epithelial-mesenchymal transition of target cells… Extracellular vesicles and ovarian cancer… UniQuest-INOVIQ Umbrella Research and Option Agreement: Exosome based ovarian cancer screening… realistic that a clinically useful antenatal screening test can be developed. Unlike diseases such as cancer… Assays for clinically relevant complications (including ovarian cancers, and obstetrical syndromes… Pancreatic cancer is the fourth most common cause of death due to cancer in the world. It is known…
I am Professor, NHMRC Investigator Fellow (EL2) and group leader (Exosome Biology Laboratory) at UQ Centre for Clinical Research. I am nationally and internationally (>20 invitations to international meetings in the last 5 years) acknowledged key opinion leader on Extracellular Vesicle (rated 3th w …
My research program focused on obstetrics and gynaecology, and it has investigated the release of extracellular vesicles by the placenta during gestation, and tumour cells in ovarian cancer progression, and their utility as a biomarker for a wide range of pregnancy complications, and ovarian cancer. …
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Cell biology: Ran, mitosis and the cancer Lconnection… Cancer chemotherapy… studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease… -9 phosphorylation in the regulation of apoptosis during development and in pathological states, including cancer.…
Paul Clarke is Director of the Frazer Institute, a leading translational medical research centre studying cancer, autoimmune diseases, infection and immunity, and the genetic basis of disease. Professor Clarke became Director in 2017 and was previously Associate Dean (Research) in Medicine at the Un …
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Salivary exosomes as potential biomarkers in cancer… signalling pathways in diseases such as obesity, diabetes, and ovarian cancer, with a focus on… exosomes mediate cancer progression and metastasis. Given the important biological role played by…
Soumyalekshmi Nair has a degree in Veterinary and Animal Sciences (2009) and a Master of Veterinary Science in Animal Biotechnology (2011) from India. She completed her PhD in 2021 from the Faculty of Medicine, the University of Queensland. In her PhD she investigated the role of extracellular vesi …
The research work on gestational diabetes elucidated the role of extracellular vesicle signalling in the regulation of glucose homeostasis in metabolic conditions. The major impact of my publications has been (1) Identifying the role of extracellular vesicle and their cargo in metabolic conditions a …
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Cancers induce immunosuppressive mechanisms, and immunotherapy can either alleviate… early cancer detection and disease monitoring. These specific adaptive immune receptors are essential… Immunotherapy for persisting viral infection and associated cancer… Approaching antigen-presenting cell immunotherapy for cervical cancers using single-cell transcriptomics… health and in cancer. Dr. Tuong was born and raised in Singapore and moved to Brisbane… precancerous neoplasia that can eventuate in cervical cancer. Dendritic cells (DCs) are efficient in priming…
Dr. Kelvin Tuong is a Senior Research Fellow/Group Leader at the Ian Frazer Centre for Children’s Immunotherapy Research (IFCCIR), Child Health Research Centre. He is interested in single-cell analysis of immune cells and harnessing adaptive immune receptors for understanding immune cell development …
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New approaches to immunotherapy for HPV associated cancer… cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens.…
Dr Kassianos is a Senior Scientist at the Conjoint Internal Medical Laboratory, Queensland Health. Dr Kassianos has made significant contributions to understanding the cell-cell communication between discrete kidney cell and immune cell populations and the therapeutic potential of targeting this cro …
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Role of the growth hormone–IGF-1 axis in cancer… Hardy Brothers Scholarship for Research in Blood Cancer at the UQ Diamantina Institute… Journal Cancers and Human Cell. He was previously a committee member of Australian Early-Mid Career… transformation and cancer can occur in response to autocrine activation of the receptor. Advances in…
Dr Andrew Brooks is the Group Leader of the Cytokine Receptor Signalling Group at the University of Queensland Diamantina Institute (UQ DI) within the Translational Research Institute. Andrew completed his Honours research on Flaviviruses in 1996 at the Department of Microbiology and Immunology at J …
Quality of Research Outputs
In the last 10 years I have published in journals including Science, Nature Cell Biology, Blood, Oncogene, J Immunol, and Nature Reviews. I have over 1000 citations (Web of Knowledge or over 1500 Google Scholar) with an h-index of 16 (Web of Knowledge) or 19 (Google Scho …
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selection in vaccine response; 3. Unraveling novel pathways sustaining T cell immunity in cancers… cancers by preventing a loss-of-function program termed 'exhaustion'. This research program has…
I am a Senior Research Fellow, NHMRC Emerging Leader Fellow, and Group Leader at UQ Frazer Institute. I was awarded my PhD in late 2017 by Biomedicine Discovery Institute, Monash University. Under the UQ Health Research Accelerator (HERA) program, I lead a team to investigate T and B cell responses …
Overall, I published 13x journal articles (6x 1st author or joint 1st author, 1x corresponding author) and 1x book chapter (1st author). The quality of my research in the field of T cell immunology was highlighted by three cutting-edge works published in Nature Immunology ( joint 1st author, 2021, s …
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immunological defenses and cancer immunosurveillance. Current research: My current research focuses… The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy… Reversing tumour necrosis factor-mediated immunosuppression to boost immunity against experimental CD19+ blood cancers… Background: Despite advances in treatment and earlier detection, cancer is… NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the…
In 2012, I achieved a significant milestone by becoming the first student to complete a doctoral degree from the prestigious International PhD Program at Institute Pasteur, Paris/France. This accomplishment not only set the trajectory of my academic pursuits but also underscored my dedication and pa …
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SCG10-like protein (SCLIP) is a STAT3-interacting protein involved in maintaining epithelial morphology in MCF-7 breast cancer cells… movement of cancer cells from one site to another, involves remodeling of the cytoskeleton including…
Dr Dominic Ng graduated with a BSc (Hons) and gained his PhD from the University of Western Australia. His doctoral studies, conducted in the laboratory of Assoc. Prof. Marie Bogoyevitch, were focused on cardiomyocyte signalling mechanisms regulating pathological tissue growth (ie cardiac hypertroph …