You searched for: cancer
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Primarily endometrial cancer… Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer… Identifying the regulatory targets of common endometrial cancer risk variants… We and our international Endometrial Cancer Association Consortium collaborators have identified… Gynaecological cancer genetics… -enzyme fusion proteins for cancer therapy. He returned to New Zealand to carry out his PhD research… Excessive exposure to estrogen is a well-established risk factor for endometrial cancer (EC…
After completing his BSc and MSc (Hons) at the University of Canterbury (NZ), Dylan worked for five years as a Research Scientist at Antisoma Research Limited (London, UK), developing antibody-enzyme fusion proteins for cancer therapy. He returned to New Zealand to carry out his PhD research into an …
Large numbers of germline genetic variants have been found to associate with disease. A major roadblock in our understanding of how genetics contribute to disease has been a lack of knowledge of the molecular effects of variants. Thus, the aim of my research program is to use genetic analyses to ass …
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Therapeutic Opportunity in Cancers with Poor Survival… Complex neoantigen prediction in cancers… genome sequencing technologies in biomedical research. In particular large cancer research…
Research officer, Medical Genomics
QIMR Berghofer Medical Research Institute
My research addressed the challenges related to key genomic components in tumour-immune editing variation in cancers with poor survival and predicting the responses to cancer immunotherapies. Characterizing genomic determinants in underlying response and resistance to cancer immunotherapy. Through w …
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Androgen receptor EXON 1 CAG repeat length and risk of ovarian cancer… Evaluation of variants in known or candidate high-risk cancer genes… underlying genetic cause of cancer in patients with suspected hereditary cancer. Identification of… Epidemiological studies indicate that ovarian cancer is an endocrine-related tumour. We conducted a…
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End-stage kidney disease following surgical management of kidney cancer… Primary Kidney Cancer Cell Culture Projects… This project involves cell culture of primary cancer cells, to develop in vivo models of disease… Background: Chronic kidney disease (CKD) after surgery for kidney cancer is common, and is…
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Systemic delivery of E6/7 siRNA using novel lipidic particles and its application with cisplatin in cervical cancer mouse models… Re-activating anti-tumour immunity by targeting N-MYC-Lec7 axis in ovarian cancer… cancer therapy. In addition to specific gene silencing, in vivo RNAi treatment with short interfering…
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Familial concordance of breast cancer pathology as an indicator of genotype in multiple-case families… Re-defining the molecular evolution of breast cancer and its precursors… Mammographic screening programs were introduced to improve outcomes for women with breast cancer by…
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CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer… to genomic instability, a hallmark of cancer. However, the mechanism by which it mediates genomic…
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Colorectal carcinogenesis: Road maps to cancer… A CpG island methylator phenotype (CIMP) is displayed by a distinct subset of colorectal cancers…
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Gene expression changes of GAEC1 in human cancers… significantly higher in NPC and ESCC samples than in their adjacent non-cancer counterparts…
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major diseases, including cancer and inflammation. One key molecule, E-cadherin, is necessary for… patients are associated with cancer, lipodystrophies (lack of fat tissue), muscular dystrophy, and cardiac… Uptake and intracellular fate of disulfide-bonded polymer hydrogel capsules for doxorubicin delivery to colorectal cancer cells… Modulating cholesterol-dependent lipid rafts and caveolin in prostate cancer therapy… Expression of caveolin-1 is up-regulated in prostate cancer metastasis and is associated with…
Our research focuses on understanding how cells work and what goes wrong in disease. We are studying the role of cellular organelles in defence against pathogens, the molecular changes underlying muscle disease, and optimising methods to deliver therapeutics to specific cell types in whole animals.
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