You searched for: chronic disease
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Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of parkinson’s disease… Novel therapeutic strategies targeting the microbiota and gut-brain axis in Parkinson's disease… Repurposing of clinically validated kinase inhibitors to block chronic neuroinflammation and disease progression in Parkinson's disease… changes seen in Parkinson's disease (PD) and other neurological disorders. Clinical studies suggest that… Clinical bio-markers for early detection of Parkinson's disease… mechanisms which drive the onset and progression of neurodegenerative disorders such as Parkinson’s disease… other related chronic neurodegenerative diseases. PK2 signals through its receptors on astrocytes and…
Dr. Richard Gordon leads a multi-disciplinary, industry-partnered research program in Translational Neuroscience which integrates immunology, drug development, pharmacology, metabolomics and microbial metagenomics. His group aims to understand and therapeutically target key pathological mechanisms w …
Dr. Gordon’s research has contributed to ground-breaking advances in the field of neuroinflammation and Parkinson’s disease, including discovery of a novel signalling paradigm for prokineticin signalling during neurodegeneration, and inflammasome activation as a driver of synuclein pathology and …
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cardiovascular disease and leads to heart failure. How the heart stiffens is poorly understood. A new… Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice… Studying the basis of and developing new therapies to treat heart disease… occurs in pathological settings such as chronic hypertension. We are interested in the role that two… Infectious Disease and Scientific Reports. Dr Reichelt’s research has most recently been… cardioprotection. The role of chronic NO deficiency in coordinating ischemic vulnerability in female…
Dr Reichelt is a tenured teaching and research academic in The University of Queensland’s School of Biomedical Sciences. She completed her PhD in cardiovascular Physiology at Griffith University, and held postdoctoral positions at The Victor Chang Cardiac Research Institute (VCCRI) in Sydney, the …
Dr Reichelt heads the Cardiac Disease and Therapy group, focused on optimising heart function in clinically relevant models of cardiovascular disease including chronic high blood pressure, heart ischemia (lack of flow), diabetes, ageing and cardiotoxicity associated with cancer therapy. Her research …
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This project aims to help understand motor neurone disease, which is a severe disease that leads to… One of the challenges of ALS is understanding disease heterogeneity. Our work studies the… syndrome and chronic inflammatory demyelinating polyradiculoneuropathy… Role and specificity of T cells and B cells in chronic autoimmune demyelinating disease… Neuromuscular disease… cells were also observed at different stages of the disease. We conclude that the CsA form of chronic…
Neurologist
Dr McCombe graduated in Medicine from UQ and completed a Science degree for medical students. She then trained as a neurologist in Sydney, at Prince Henry and Prince of Wales Hospitals. She obtained a PhD from the University of Sydney. She obtained experience in Neurophysiology in Cleve …
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IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans… Epithelial tissue mechanics: a new key to relapse in chronic inflammatory bowel disease… Disease (IBD). Dr Begun first joined Mater Research - University of Queensland in 2014, and… inflammatory bowel disease (IBD) often require chronic immunosuppression, which can influence vaccination…
Associate Professor Jakob Begun is the IBD Group leader in the Immunity, Infection, and Inflammation Program at Mater Research University of Queensalnd, and has a basic and translational laboratory at the Translational Research Institute in Brisbane. He is an Associate Professor in the University of …
Inflammatory bowel disease(IBD) is a complex disease with genetic and environmental triggers. The microbiota is one of the biggest environmental contributors and interest in its impact on human health and disease is a growing. Studies in IBD have led the way in identifying disease associated microbi …
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Expression of the iron regulatory peptide hepcidin is reduced in patients with chronic liver disease… Pathogenic mechanisms underlying iron co-toxicity in chronic liver disease… of Medicine. Her current research focuses on liver disease treatment and pathogenesis with a focus… fibrosis, a common pathological basis of chronic liver diseases (CLDs), in preclinical animal models…
Dr Kim Bridle is currently Senior Research Officer within the Greenslopes Clinical Unit, Faculty of Medicine. Her current research focuses on liver disease treatment and pathogenesis with a focus on hepatic fibrosis, metabolic fatty liver disease and liver cancer. Dr Bridle has made important contri …
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An evidence-based checklist for acute exacerbations of chronic obstructive pulmonary disease… Genome-wide association study of protective alleles in lung cancer and chronic obstructive pulmonary disease… Purpose: Molecular biomarkers for chronic obstructive pulmonary disease (COPD) severity have been…
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pathogenesis of acute lung injury (ALI) and diabetic kidney disease. Since ischaemia-reperfusion is… Frozen section of pleural biopsies at medical thoracoscopy assists in correctly identifying benign disease… Conquering the final frontier in lung transplantation - Mesenchymal stromal cell therapy for chronic lung allograft dysfunction… disease progression in IPF and offer hope to patients afflicted with this chronic lung disease… Advanced chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity…
Overview
My career in medicine commenced at the University of Queensland, graduating in 1993 with MBBS (Hons 1), University Gold Medal, Alexander Bell and Elizabeth Raff Memorial Prize 1988, Ciba-Giegy Prize 1991 and Certificate of Commendation 1992. I have practiced medicine in multiple jurisdicti …
Professor Hopkins is a recognised thought leader in the fields of lung transplantation, interstitial lung disease, interventional bronchoscopy and pulmonary vascular disease. His research contributions to these fields have translated into clinical practice improvements in the management of chronic l …
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Phosphate binders in patients with chronic kidney disease… Background: Frailty is prevalent in older people with chronic kidney disease (CKD) and robust…
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Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data… Assess the clinical disease-modifying effects of one peptide test item given twice-weekly for 3… care than almost all other diseases combined. In the preclinical setting, the…
Dr Andy Kuo is a Postdoctoral Research Fellow and Team Leader at the Centre for Integrated Preclinical Drug Development (CIPDD), Faculty of Medicine and Biomedical Sciences at The University of Queensland. Andy had extensive training in efficacy profiling and new drug development in the pain field, …
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An evidence-based checklist for acute exacerbations of chronic obstructive pulmonary disease… Genome-wide association study of protective alleles in lung cancer and chronic obstructive pulmonary disease… research discoveries to improving outcomes and the health of people who are affected by lung disease… Chronic obstructive pulmonary disease (COPD) is a major public health problem. The aim of this…
Kwun is a Thoracic and Sleep Physician at The Prince Charles Hospital and University of Queensland Thoracic Research Centre (UQTRC). His research interests are focussed on making and translating research discoveries to improving outcomes and the health of people who are affected by lung disease part …
Lung cancer is the leading cause of cancer mortality in Australia and globally. The prevention, early detection/screening and optimal management of lung cancer will help address the huge burden from lung cancer, enabled by high impact research and addressing stigma and nihilism and the health dispar …