The University of Queensland

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 1-16. doi: 10.1038/s41380-024-02509-5

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023

Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry

Carlisle, Alison Keolani, Götz, Jürgen and Bodea, Liviu-Gabriel (2023). Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry. STAR Protocols, 4 (3) 102418, 102418. doi: 10.1016/j.xpro.2023.102418

Editorial: the neuron-glia crosstalk and beyond

Middeldorp, Jinte, Min, Rogier, Benetatos, Joseph and Bodea, Liviu-Gabriel (2023). Editorial: the neuron-glia crosstalk and beyond. Frontiers in Cellular Neuroscience, 17 1159597, 1-3. doi: 10.3389/fncel.2023.1159597

Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses

Milner, Mark T., Lawrence, Grace M. E. P., Holley, Caroline L., Bodea, Liviu-Gabriel, Götz, Jürgen, Burgener, Sabrina S. and Schroder, Kate (2022). Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses. STAR Protocols, 3 (2) 101295, 1-16. doi: 10.1016/j.xpro.2022.101295

Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound

Leinenga, Gerhard, Bodea, Liviu‐Gabriel, Schröder, Jan, Sun, Giuzhi, Zhou, Yichen, Song, Jae, Grubman, Alexandra, Polo, Jose M. and Götz, Jürgen (2022). Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound. Bioengineering & Translational Medicine, 8 (1) e10329, e10329. doi: 10.1002/btm2.10329

LINE-1 retrotransposon activation intrinsic to interneuron development

Bodea, Gabriela O., Ferreiro, Maria E., Sanchez-Luque, Francisco J., Botto, Juan M., Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H.C., Love, Chloe J., Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J. and Faulkner, Geoffrey J. (2022). LINE-1 retrotransposon activation intrinsic to interneuron development.

An early proinflammatory transcriptional response to tau pathology is age‐specific and foreshadows reduced tau burden

Rasmussen, Jay, Ewing, Adam D., Bodea, Liviu‐Gabriel, Bodea, Gabriela O., Gearing, Marla and Faulkner, Geoffrey J. (2021). An early proinflammatory transcriptional response to tau pathology is age‐specific and foreshadows reduced tau burden. Brain Pathology, 32 (3) e13018, e13018. doi: 10.1111/bpa.13018

Altered ribosomal function and protein synthesis caused by tau

Evans, Harrison Tudor, Taylor, Deonne, Kneynsberg, Andrew, Bodea, Liviu-Gabriel and Götz, Jürgen (2021). Altered ribosomal function and protein synthesis caused by tau. Acta Neuropathologica Communications, 9 (1) 110, 110. doi: 10.1186/s40478-021-01208-4

De novo proteomic methods for examining the molecular mechanisms underpinning long-term memory

Evans, Harrison Tudor, Blackmore, Daniel, Goetz, Juergen and Bodea, Liviu-Gabriel (2021). De novo proteomic methods for examining the molecular mechanisms underpinning long-term memory. Brain Research Bulletin, 169, 94-103. doi: 10.1016/j.brainresbull.2020.12.015

Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice

Bajracharya, Rinie, Brici, David, Bodea, Liviu-Gabriel, Janowicz, Phillip W., Götz, Jürgen and Nisbet, Rebecca M. (2021). Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice. Acta Neuropathologica Communications, 9 (1) 42, 1-13. doi: 10.1186/s40478-021-01147-0

Delivery of antibodies into the brain using focused scanning ultrasound

Leinenga, Gerhard, Bodea, Liviu-Gabriel, Koh, Wee Kiat, Nisbet, Rebecca M. and Götz, Jürgen (2020). Delivery of antibodies into the brain using focused scanning ultrasound. Journal of Visualized Experiments, 2020 (161) e61372, 1-13. doi: 10.3791/61372

PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy

Benetatos, Joseph, Bennett, Rachel E., Evans, Harrison T., Ellis, Sevannah A., Hyman, Bradley T., Bodea, Liviu-Gabriel and Götz, Jürgen (2020). PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy. Acta Neuropathologica, 140 (1), 7-24. doi: 10.1007/s00401-020-02151-9

Cell-specific non-canonical amino acid labelling identifies changes in the de novo proteome during memory formation

Evans, Harrison Tudor, Bodea, Liviu-Gabriel and Götz, Jürgen (2020). Cell-specific non-canonical amino acid labelling identifies changes in the de novo proteome during memory formation. eLife, 9 e52990, e52990. doi: 10.7554/elife.52990

Decreased synthesis of ribosomal proteins in tauopathy revealed by non‐canonical amino acid labelling

Evans, Harrison Tudor, Benetatos, Joseph, van Roijen, Marloes, Bodea, Liviu‐Gabriel and Götz, Jürgen (2019). Decreased synthesis of ribosomal proteins in tauopathy revealed by non‐canonical amino acid labelling. The EMBO Journal, 38 (13) e101174, e101174. doi: 10.15252/embj.2018101174

TREM2 triggers microglial density and age-related neuronal loss

Linnartz-Gerlach, Bettina, Bodea, Liviu-Gabriel, Klaus, Christine, Ginolhac, Aurélien, Halder, Rashi, Sinkkonen, Lasse, Walter, Jochen, Colonna, Marco and Neumann, Harald (2019). TREM2 triggers microglial density and age-related neuronal loss. GLIA, 67 (3) glia.23563, 539-550. doi: 10.1002/glia.23563

Rodent models for Alzheimer disease

Götz, Jürgen, Bodea, Liviu-Gabriel and Goedert, Michel (2018). Rodent models for Alzheimer disease. Nature Reviews Neuroscience, 19 (10), 583-598. doi: 10.1038/s41583-018-0054-8

Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies

Polanco, Juan Carlos, Li, Chuanzhou, Bodea, Liviu-Gabriel, Martinez-Marmol, Ramon, Meunier, Frederic A and Götz, Jürgen (2017). Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies. Nature reviews. Neurology, 14 (1), 22-40. doi: 10.1038/nrneurol.2017.162

Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model

Bodea, Liviu-Gabriel, Evans, Harrison Tudor, Van der Jeugd, Ann, Ittner, Lars M., Delerue, Fabien, Kril, Jillian, Halliday, Glenda, Hodges, John, Kiernan, Mathew C. and Goetz, Juergen (2017). Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell, 16 (2), 377-386. doi: 10.1111/acel.12565

Tau physiology and pathomechanisms in frontotemporal lobar degeneration

Bodea, Liviu-Gabriel, Eckert, Anne, Ittner, Lars Matthias, Piguet, Olivier and Götz, Juergen (2016). Tau physiology and pathomechanisms in frontotemporal lobar degeneration. Journal of Neurochemistry, 138 (S1), 71-94. doi: 10.1111/jnc.13600

Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis

Capurro, Alberto, Bodea, Liviu-Gabriel, Schaefer, Patrick, Luthi-Carter, Ruth and Perreau, Victoria M. (2015). Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis. Frontiers in Neuroscience, 8 (441) 441, 1-12. doi: 10.3389/fnins.2014.00441

Neurodegeneration by activation of the microglial complement-phagosome pathway

Bodea, Liviu-Gabriel, Wang, Yiner, Linnartz-Gerlach, Bettina, Kopatz, Jens, Sinkkonen, Lasse, Musgrove, Ruth, Kaoma, Tony, Muller, Arnaud, Vallar, Laurent, Di Monte, Donato A., Balling, Rudi and Neumann, Harald (2014). Neurodegeneration by activation of the microglial complement-phagosome pathway. Journal of Neuroscience, 34 (25), 8546-8556. doi: 10.1523/JNEUROSCI.5002-13.2014

Siglec-h on activated microglia for recognition and engulfment of glioma cells

Kopatz, Jens, Beutner, Clara, Welle, Kristian, Bodea, Liviu G., Reinhardt, Julia, Claude, Janine, Linnartz-Gerlach, Bettina and Neumann, Harald (2013). Siglec-h on activated microglia for recognition and engulfment of glioma cells. GLIA, 61 (7), 1122-1133. doi: 10.1002/glia.22501

Water Soluble Pleurotus ostreatus Polysaccharide Down-Regulates the Expression of MMP-2 and MMP-9 in Caco-2 Cells

Cojocaru, Sabina, Radu, Mihaela, Bodea, Liviu G., Cimpeanu, Mirela M., Gheorghita, Gogu, Stoian, Gheorghe and Dinischiotu, Anca (2013). Water Soluble Pleurotus ostreatus Polysaccharide Down-Regulates the Expression of MMP-2 and MMP-9 in Caco-2 Cells. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 41 (2), 553-559. doi: 10.15835/nbha4129305

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

Zhang, Bin, Gaiteri, Chris, Bodea, Liviu-Gabriel, Wang, Zhi, McElwee, Joshua, Podtelezhnikov, Alexei A., Zhang, Chunsheng, Xie, Tao, Tran, Linh, Dobrin, Radu, Fluder, Eugene, Clurman, Bruce, Melquist, Stacey, Narayanan, Manikandan, Suver, Christine, Shah, Hardik, Mahajan, Milind, Gillis, Tammy, Mysore, Jayalakshmi, MacDonald, Marcy E., Lamb, John R., Bennett, David A., Molony, Cliona, Stone, David J., Gudnason, Vilmundur, Myers, Amanda J., Schadt, Eric E., Neumann, Harald, Zhu, Jun and Emilsson, Valur (2013). Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell, 153 (3), 707-720. doi: 10.1016/j.cell.2013.03.030

Microglial carbohydrate-binding receptors for neural repair

Linnartz, Bettina, Bodea, Liviu-Gabriel and Neumann, Harald (2012). Microglial carbohydrate-binding receptors for neural repair. Cell and Tissue Research, 349 (1), 215-227. doi: 10.1007/s00441-012-1342-7

The effect of deoxynivalenol on hepatic cell line HepG2

Dragomir, G., Huculeci, R., Munteanu, C., Ceapa, C., Bodea, L. and Dinischiotu, A. (2007). The effect of deoxynivalenol on hepatic cell line HepG2. Biotechnology in Animal Husbandry, 23 (5-6-1), 583-588. doi: 10.2298/bah0701583d

Neurodegeneration by a microglial complement-phagosome pathway

Bodea, L., Linnartz-Gerlach, B., Kopatz, J., Sinkkonen, L., Balling, R. and Neumann, H. (2015). Neurodegeneration by a microglial complement-phagosome pathway. 12th European Meeting on Glial Cell Function in Health and Disease, Bilbao, Spain, Jul 15-18, 2015. Hoboken, United States: John Wiley & Sons. doi: 10.1002/glia.22870

Lack of Microglial Trem2 Receptor Increases Susceptibility to Dopaminergic Degeneration Triggered by Systemic Inflammation

Bodea, L. -G., Colonna, M. and Neumann, H. (2013). Lack of Microglial Trem2 Receptor Increases Susceptibility to Dopaminergic Degeneration Triggered by Systemic Inflammation. 11th European Meeting on Glial Cell Function in Health and Disease, Berlin Germany, Jul 03-06, 2013. HOBOKEN: WILEY-BLACKWELL.

Desialylation of Neuronal Processes Leads to Complement Opsonization and Complement Receptor-3 Dependent Removal by Microglia

Linnartz, B., Bodea, L. G., Tenner, A. and Neumann, H. (2011). Desialylation of Neuronal Processes Leads to Complement Opsonization and Complement Receptor-3 Dependent Removal by Microglia. WILEY-BLACKWELL.

Microglial Clearance in Neurodegenerative Diseases

Neumann, H., Linnartz, B. and Bodea, L. (2011). Microglial Clearance in Neurodegenerative Diseases. WILEY-BLACKWELL.

Microglial Trem2 Receptor Has a Protective Role for the Nigrostriatal System

Bodea, L. G., Linnartz, B., Colonna, M. and Neumann, H. (2011). Microglial Trem2 Receptor Has a Protective Role for the Nigrostriatal System. WILEY-BLACKWELL.

Regulation of Dap12 Associated Receptors in Microglia by Systemic Inflammatory Stimuli

Bodea, L. G., Dannenberg, H., Colonna, M. and Neumann, H. (2009). Regulation of Dap12 Associated Receptors in Microglia by Systemic Inflammatory Stimuli. 9th European Meeting on Glial Cells in Health and Disease, Paris France, Sep 08-12, 2009. WILEY-LISS.

Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Youse, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2023). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction.