Postdoctoral Research Fellow -Novel
Overview
Dr. Wang completed her MPhil study in the University of Queensland (UQ) in 2016 and PhD study in UQ in October 2020. As an early career researcher, Dr.Wang has demonstrated a high impact track record relative to opportunity with award of Dean's award for Excellence in Higher Degree Research (2016), the high proportion (41%) of first-authored publications, 28% of which in the top 10% most cited publications worldwide (Scopus 24/03/2021). She has been actively engaged in a number of professional activities in the research fields, including RHD student supervision, assessment for the master research projects (BIOX7021), talks at national and international conferences (The Australian Colloid and Interface Symposium Brisbane hub, 2021; The Australasian Society for Stem Cell Research ECR Symposium, 2021; BioNano Innovation, 2020) and conference organization (The Australian Colloid and Interface Symposium Brisbane hub, 2021).
Research Interests
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Nanochemistry upregulated mRNA translation
Dr. Wang has pioneered the conceptual design of functional nanomaterials with glutathione-depletion chemistry for upregulated mRNA translation and delivery. She has revealed the contribution of tetrasulfide bond composition of nanoparticles to GSH depletion and activation of mammalian target of rapamycin complex1 pathway for stimulated mRNA translation and enhanced delivery efficiency in hard-to-transfect APCs. This work demonstrates that, for the first time, nanoparticles not only act as a carrier for mRNA, but also a regulator to modulate mRNA translation machineries and pathways. This presents a new research direction that has not been reported. Considering the intrinsic GSH regeneration catalysed by intracellular glutathione reductase (GR), She further developed a confined growth technology to prepare zeolitic imidazolate framework-8 (ZIF-8) and MONs complex (MONs-ZIF-8), with zinc cations inhibited GR activity and tetrasulfide bond triggered GSH oxidation to synergistically enable long-term GSH depletion and enhanced mRNA delivery .
Qualifications
- Doctor of Philosophy, The University of Queensland
Publications
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Journal Article: Mesoporous Organosilica Nanoparticles with Tetrasulphide Bond to Enhance Plasmid DNA Delivery
Zhang, Yue, Xian, He, Strounina, Ekaterina, Gunther, Kimberley S., Sweet, Matthew J., Chen, Chen, Yu, Chengzhong and Wang, Yue (2023). Mesoporous Organosilica Nanoparticles with Tetrasulphide Bond to Enhance Plasmid DNA Delivery. Pharmaceutics, 15 (3) 1013, 1-11. doi: 10.3390/pharmaceutics15031013
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Journal Article: Nanobiotechnology-enabled mRNA stabilization
Xian, He, Zhang, Yue, Yu, Chengzhong and Wang, Yue (2023). Nanobiotechnology-enabled mRNA stabilization. Pharmaceutics, 15 (2) 620. doi: 10.3390/pharmaceutics15020620
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Song, Yaping, Sun, Qiang, Luo, Jiangqi, Kong, Yueqi, Pan, Bolin, Zhao, Jing, Wang, Yue and Yu, Chengzhong (2022). Cationic and anionic antimicrobial agents co-templated mesostructured silica nanocomposites with a spiky nanotopology and enhanced biofilm inhibition performance. Nano-Micro Letters, 14 (1) 83, 83. doi: 10.1007/s40820-022-00826-4
Available Projects
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Developing nanostructured antimicrobial coating for biomedical devices
Biomedical devices such as catheters are routinely used in a diverse range of clinical settings, the inevitable bacterial infection remains a major threat to human health. Among them, catheter-associated-urinary tract infections are a global challenge and difficult to treat due to the formation of biofilms. Traditional treatment using antibiotics leads to ever increasing antibiotics resistance. This project will use state-of-the-art nanotechnology to solve the above problems. Novel silica nanoparticles with a pollen-like morphology will be prepared to disrupt bacterial membrane. Their compositions can be tuned to cause chemical damage towards bacteria. The impacts of various structural parameters on catheter coating, antiadhesive, antibacterial and antibiofilm performances as well as urinary drainage flow will be evaluated. If successful, this technology can be used to develop next-generation antibacterial coating for biomedical devices, providing invaluable benefits to human healthcare.
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Developing efficient nano-transfection agents for mRNA vaccine delivery
The mRNA technology has received tremendous success in the development of COVID vaccines, however the performance of current mRNA cancer vaccines is low. Roche and BioNTech collaborated mRNA based personalized cancer vaccines (RO7198457 cancer vaccine) only gave a 4% response rate. Based on our ground-breaking findings of nanochemistry upregulated mRNA translation, this project aims to develop a new-generation of mRNA cancer vaccine formulations with improved efficacy. New delivery platforms will be prepared to improve the mRNA cancer vaccine performance and simplify the dosages. The impact of structural parameters of nano-carriers on mRNA transfection, antigen presenting and cellular immunity will be systematically investigated. Successful completion of this project has the potential to provide a revolutionised mRNA cancer vaccine technology.
Publications
Journal Article
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Mesoporous Organosilica Nanoparticles with Tetrasulphide Bond to Enhance Plasmid DNA Delivery
Zhang, Yue, Xian, He, Strounina, Ekaterina, Gunther, Kimberley S., Sweet, Matthew J., Chen, Chen, Yu, Chengzhong and Wang, Yue (2023). Mesoporous Organosilica Nanoparticles with Tetrasulphide Bond to Enhance Plasmid DNA Delivery. Pharmaceutics, 15 (3) 1013, 1-11. doi: 10.3390/pharmaceutics15031013
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Nanobiotechnology-enabled mRNA stabilization
Xian, He, Zhang, Yue, Yu, Chengzhong and Wang, Yue (2023). Nanobiotechnology-enabled mRNA stabilization. Pharmaceutics, 15 (2) 620. doi: 10.3390/pharmaceutics15020620
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Song, Yaping, Sun, Qiang, Luo, Jiangqi, Kong, Yueqi, Pan, Bolin, Zhao, Jing, Wang, Yue and Yu, Chengzhong (2022). Cationic and anionic antimicrobial agents co-templated mesostructured silica nanocomposites with a spiky nanotopology and enhanced biofilm inhibition performance. Nano-Micro Letters, 14 (1) 83, 83. doi: 10.1007/s40820-022-00826-4
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Synthesis of mesoporous organosilica nanoparticles with a high tetrasulphide content and large pores
Zhang, Yue, Wang, Yue, Song, Yaping, Luo, Jiangqi, Yu, Yingjie and Yu, Chengzhong (2022). Synthesis of mesoporous organosilica nanoparticles with a high tetrasulphide content and large pores. Microporous and Mesoporous Materials, 346 112316, 112316. doi: 10.1016/j.micromeso.2022.112316
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Tang, Jie, Yang, Yang, Qu, Jingjing, Ban, Wenhuang, Song, Hao, Gu, Zhengying, Yang, Yannan, Cai, Larry, Theivendran, Shevanuja, Wang, Yue, Zhang, Min and Yu, Chengzhong (2022). Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity. Chemical Science, 13 (29), 8507-8517. doi: 10.1039/d1sc05319a
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Dendritic mesoporous nanoparticles: structure, synthesis and properties
Xu, Chun, Lei, Chang, Wang, Yue and Yu, Chengzhong (2022). Dendritic mesoporous nanoparticles: structure, synthesis and properties. Angewandte Chemie International Edition, 61 (12) e202112752, 1-22. doi: 10.1002/anie.202112752
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Dendritic mesoporous nanoparticles: structure, synthesis and properties
Xu, Chun, Lei, Chang, Wang, Yue and Yu, Chengzhong (2022). Dendritic mesoporous nanoparticles: structure, synthesis and properties. Angewandte Chemie, 134 (12) e202112752, 1-22. doi: 10.1002/ange.202112752
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Kothalawala, Sukitha Geethma, Zhang, Jun, Wang, Yue and Yu, Chengzhong (2021). Submicron-sized vermiculite assisted oregano oil for controlled release and long-term bacterial inhibition. Antibiotics, 10 (11) 1324. doi: 10.3390/antibiotics10111324
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Cao, Yuxue, Xu, Chun, Wright, Patricia P., Liu, Jingyu, Kong, Yueqi, Wang, Yue, Huang, Xiaodan, Song, Hao, Fu, Jianye, Gao, Fang, Liu, Yang, Walsh, Laurence J. and Lei, Chang (2021). Calcium-doped silica nanoparticles mixed with phosphate-doped silica nanoparticles for rapid and stable occlusion of dentin tubules. ACS Applied Nano Materials, 4 (9) acsanm.1c01365, 8761-8769. doi: 10.1021/acsanm.1c01365
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Gu, Zhengying, Liu, Tianqing, Liu, Chao, Yang, Yannan, Tang, Jie, Song, Hao, Wang, Yue, Yang, Yang and Yu, Chengzhong (2021). Ferroptosis-strengthened metabolic and inflammatory regulation of tumor-associated macrophages provokes potent tumoricidal activities. Nano Letters, 21 (15) acs.nanolett.1c01401, 6471-6479. doi: 10.1021/acs.nanolett.1c01401
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Benzene-bridged organosilica modified mesoporous silica nanoparticles via an acid-catalysis approach
Zhang, Ye, Gu, Zhengying, Liu, Yang, Hu, Wenli, Liu, Chao, Shu, Weikang, Wang, Yue and Yu, Chengzhong (2021). Benzene-bridged organosilica modified mesoporous silica nanoparticles via an acid-catalysis approach. Langmuir, 37 (8), 2780-2786. doi: 10.1021/acs.langmuir.0c03541
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Emerging concepts of nanobiotechnology in mRNA delivery
Wang, Yue and Yu, Chengzhong (2020). Emerging concepts of nanobiotechnology in mRNA delivery. Angewandte Chemie International Edition, 59 (52) anie.202003545, 23374-23385. doi: 10.1002/anie.202003545
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Tang, Jie, Meka, Anand Kumar, Theivendran, Shevanuja, Wang, Yue, Yang, Yannan, Song, Hao, Fu, Jianye, Ban, Wenhuang, Gu, Zhengying, Lei, Chang, Li, Shumin and Yu, Chengzhong (2020). Openwork@Dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation. Angewandte Chemie International Edition, 59 (49) anie.202001469, 22054-22062. doi: 10.1002/anie.202001469
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Wang, Yue, Song, Hao, Liu, Chao, Zhang, Ye, Kong, Yueqi, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2020). Confined growth of ZIF-8 in dendritic mesoporous organosilica nanoparticles as bio-regulators for enhanced mRNA delivery in vivo. National Science Review, 8 (8) nwaa268, 1-10. doi: 10.1093/nsr/nwaa268
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Eliciting immunogenic cell death via a unitized nanoinducer
Dai, Zan, Tang, Jie, Gu, Zhengying, Wang, Yue, Yang, Yang, Yang, Yannan and Yu, Chengzhong (2020). Eliciting immunogenic cell death via a unitized nanoinducer. Nano Letters, 20 (9), 6246-6254. doi: 10.1021/acs.nanolett.0c00713
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Moderne Konzepte der Nanobiotechnologie für mRNA‐Abgabesysteme
Wang, Yue and Yu, Chengzhong (2020). Moderne Konzepte der Nanobiotechnologie für mRNA‐Abgabesysteme. Angewandte Chemie, 132 (52) ange.202003545, 23578-23590. doi: 10.1002/ange.202003545
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Jambhrunkar, M., Yang, Y., Yu, M., Zhang, M., Abbaraju, P. L., Ghosh, T., Kalantari, M., Wang, Y., McMillan, N. A. J. and Yu, C. (2020). Pristine large pore benzene-bridged mesoporous organosilica nanoparticles as an adjuvant and co-delivery platform for eliciting potent antitumor immunity. Materials Today Advances, 6 100069, 100069. doi: 10.1016/j.mtadv.2020.100069
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Yu, Rongtai, Huang, Xiaodan, Liu, Yang, Kong, Yueqi, Gu, Zhengying, Yang, Yang, Wang, Yue, Ban, Wenhuang, Song, Hao and Yu, Chengzhong (2020). Shaping nanoparticles for interface catalysis: concave hollow spheres via deflation–inflation asymmetric growth. Advanced Science, 7 (13) 2000393, 2000393. doi: 10.1002/advs.202000393
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Wang, Yue, Yang, Yannan, Shi, Yiru, Song, Hao and Yu, Chengzhong (2020). Antibiotic‐free strategies: antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives (Adv. Mater. 18/2020). Advanced Materials, 32 (18) 2070138, 2070138. doi: 10.1002/adma.202070138
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Wang, Yue, Tang, Jie, Yang, Yannan, Song, Hao, Fu, Jianye, Gu, Zhengying and Yu, Chengzhong (2020). Functional nanoparticles with a reducible tetrasulfide motif to upregulate mRNA translation and enhance transfection in hard-to-transfect cells. Angewandte Chemie International Edition, 132 (7) ange.201914264, 2717-2721. doi: 10.1002/anie.201914264
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Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment
Theivendran, Shevanuja, Tang, Jie, Lei, Chang, Yang, Yannan, Song, Hao, Gu, Zhengying, Wang, Yue, Yang, Yang, Jin, Lei and Yu, Chengzhong (2020). Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment. Chemical Science, 11 (38), 10421-10430. doi: 10.1039/d0sc02803g
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Antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives
Wang, Yue, Yang, Yannan, Shi, Yiru, Song, Hao and Yu, Chengzhong (2019). Antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives. Advanced Materials, 32 (18) 1904106, 1904106. doi: 10.1002/adma.201904106
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DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles
Song, Hao, Yang, Yannan, Tang, Jie, Gu, Zhengying, Wang, Yue, Zhang, Min and Yu, Chengzhong (2019). DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles. Advanced Therapeutics, 3 (1) 1900154, 1900154. doi: 10.1002/adtp.201900154
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Wang, Yue, Song, Hao, Yang, Yannan, Liu, Yang, Tang, Jie and Yu, Chengzhong (2018). Kinetically controlled dendritic mesoporous silica nanoparticles: from dahlia- to pomegranate-like structures by micelle filling. Chemistry of Materials, 30 (16) acs.chemmater.8b02712, 5770-5776. doi: 10.1021/acs.chemmater.8b02712
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Wang, Yue, Song, Hao, Yu, Meihua, Xu, Chun, Liu, Yang, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2018). Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance. Journal of Materials Chemistry B, 6 (24), 4089-4095. doi: 10.1039/c8tb00544c
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Nor, Yusilawati Ahmad, Zhang, Hongwei, Purwajanti, Swasmi, Song, Hao, Meka, Anand Kumar, Wang, Yue, Mitter, Neena, Mahony, Donna and Yu, Chengzhong (2016). Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure-release relationship for prolonged antibacterial performance. Journal of Materials Chemistry B, 4 (43), 7014-7021. doi: 10.1039/c6tb01778a
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Wang, Jiao, Wang, Yue, Liu, Qiang, Yang, Linnan, Zhu, Rongrong, Yu, Chengzhong and Wang, Shilong (2016). Rational design of multifunctional dendritic mesoporous silica nanoparticles to load curcumin and enhance efficacy for breast cancer therapy. ACS Applied Materials and Interfaces, 8 (40), 26511-26523. doi: 10.1021/acsami.6b08400
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Wang, Yue, Nor, Yusilawati Ahmad, Song, Hao, Yang, Yannan, Xu, Chun, Yu, Meihua and Yu, Chengzhong (2016). Small-sized and large-pore dendritic mesoporous silica nanoparticles enhance antimicrobial enzyme delivery. Journal of Materials Chemistry B, 4 (15), 2646-2653. doi: 10.1039/c6tb00053c
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Yang, Yannan, Yu, Meihua, Song, Hao, Wang, Yue and Yu, Chengzhong (2015). Preparation of fluorescent mesoporous hollow silica-fullerene nanoparticles via selective etching for combined chemotherapy and photodynamic therapy. Nanoscale, 7 (28), 11894-11898. doi: 10.1039/c5nr02769a
Other Outputs
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Designed synthesis of silica based nanocarriers for mRNA delivery
Wang, Yue (2020). Designed synthesis of silica based nanocarriers for mRNA delivery. PhD Thesis, Australian Institute for Bioengineering & Nanotechnology, The University of Queensland. doi: 10.14264/b28d1e7
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Wang, Yue (2016). Designed synthesis of large pore mesoporous silica nanoparticles as nano-carriers for bio-applications. MPhil Thesis, Aust Institute for Bioengineering & Nanotechnology, The University of Queensland. doi: 10.14264/uql.2016.816
Possible Research Projects
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
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Developing nanostructured antimicrobial coating for biomedical devices
Biomedical devices such as catheters are routinely used in a diverse range of clinical settings, the inevitable bacterial infection remains a major threat to human health. Among them, catheter-associated-urinary tract infections are a global challenge and difficult to treat due to the formation of biofilms. Traditional treatment using antibiotics leads to ever increasing antibiotics resistance. This project will use state-of-the-art nanotechnology to solve the above problems. Novel silica nanoparticles with a pollen-like morphology will be prepared to disrupt bacterial membrane. Their compositions can be tuned to cause chemical damage towards bacteria. The impacts of various structural parameters on catheter coating, antiadhesive, antibacterial and antibiofilm performances as well as urinary drainage flow will be evaluated. If successful, this technology can be used to develop next-generation antibacterial coating for biomedical devices, providing invaluable benefits to human healthcare.
-
Developing efficient nano-transfection agents for mRNA vaccine delivery
The mRNA technology has received tremendous success in the development of COVID vaccines, however the performance of current mRNA cancer vaccines is low. Roche and BioNTech collaborated mRNA based personalized cancer vaccines (RO7198457 cancer vaccine) only gave a 4% response rate. Based on our ground-breaking findings of nanochemistry upregulated mRNA translation, this project aims to develop a new-generation of mRNA cancer vaccine formulations with improved efficacy. New delivery platforms will be prepared to improve the mRNA cancer vaccine performance and simplify the dosages. The impact of structural parameters of nano-carriers on mRNA transfection, antigen presenting and cellular immunity will be systematically investigated. Successful completion of this project has the potential to provide a revolutionised mRNA cancer vaccine technology.
