Dr Mostafa Kamal Masud

Postdoctoral Research Fellow

Australian Institute for Bioengineering and Nanotechnology

Overview

Dr Mostafa Kamal Masud is a CCQ Next Generation Cancer Research Fellow at the Australian Institute for Bioengineering & Nanotechnology (AIBN), the University of Queensland (UQ). In 2020, he received his PhD in Medical Biotechnology Diagnostics and Nanobiotechnology from AIBN, UQ. He received his MS and B.Sc. (Hons.) in Chemistry from Shahjalal University of Science and Technology (SUST), Sylhet-3114, Bangladesh. After completing his PhD, he was awarded a prestigious JSPS Postdoctoral Fellowship (success rate >10%) from Japan and served as a Postdoctoral Fellow at Japan's National Institute for Materials Science (NIMS).He recently been awarded a highly prestigious ARC DECRA fellowship for the period 2024-2026 and a QLD Cancer Council fellowship for the period 2024–2028. His research focuses on the development of novel nanostructures and nanodiagnostic technologies to address critical issues in medical diagnosis. As an early career researcher, he has an excellent track record with more than 50 peer-reviewed publications in prestigious and high-impact journals in the area that achieve <2400 citations with an h-index of 26 (Scholar google link: https://bit.ly/2Vtv67l). He has developed new classes of superparamagnetic nanostructures and fabricated novel biosensors for the detection of disease-specific biomolecular targets e.g., for miRNA, DNA, exosome and protein biomarker detection that have proven to be easy and effective, allowing for rapid diagnosis with minimal equipment. He made a major contribution to nanotechnology integrated-analytical and diagnostic fields by providing analytical and technological input as well as developing key collaborations with clinicians and biologists for translational research. His strategy is to create nano-architecture point-of-care diagnostic technology for early diagnosis of cancer that could hopefully lead to a healthy and happier life for humans.

Research Interests

  • Nanoarchitectonics
  • Medical Diagnostics
  • Biosensor
  • Nanobiotechnology

Research Impacts

Dr Masud pioneered the synthesis of new classes of superparamagnetic nanostructures specific to targeting biomarkers or capturing antibodies. His synthesized nanostructures perform rapid isolation based on simple magnetism and exhibit intrinsic peroxidase activities, substantially replacing the expensive natural enzyme (HRP) in immunoassays and strip-based sensing. These nanostructures are utilized in fabricating novel biosensors for detecting disease-specific biomarkers such as microRNA, autoantibodies, and extracellular vesicles (exosomes). This research has advanced the field from polymer- or centrifuge-based isolation and enzyme-based detection to more efficient and straightforward synthesis of target-specific mesoporous nanostructures, magnetic isolation, and single-step detection.

He also led the development of highly sensitive mesoporous gold (and alloy) transduction surfaces, simplifying the process from complex to single-step. His research characterized biomarkers (exosomal miRNAs), transduction surface interactions, bindings, and sensitive signal generation. He also led the translation of such mesoporous systems into wearable and flexible substrates, demonstrating high neural activity in a mouse model, thereby advancing the field of wearable diagnostics. To translate his research into clinical settings, he has initiated collaborations with clinicians, engineers, and IoT specialists

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Masters (Research) of Inorganic Chemistry
  • Bachelor (Honours) of Chemistry

Publications

  • Kang, Yunqing, Masud, Mostafa Kamal, Guo, Yanna, Zhao, Yingji, Nishat, Zakia Sultana, Zhao, Jingjing, Jiang, Bo, Sugahara, Yoshiyuki, Pejovic, Tanja, Morgan, Terry, Hossain, Md Shahriar A., Li, Hexing, Salomon, Carlos, Asahi, Toru and Yamauchi, Yusuke (2023). Au-loaded superparamagnetic mesoporous bimetallic CoFeB nanovehicles for sensitive autoantibody detection. ACS Nano, 17 (4), 3346-3357. doi: 10.1021/acsnano.2c07694

  • Nishat, Zakia Sultana, Hossain, Tanvir, Islam, Md. Nazmul, Phan, Hoang‐Phuong, Wahab, Md A., Moni, Mohammad Ali, Salomon, Carlos, Amin, Mohammed A., Sina, Abu Ali Ibn, Hossain, Md Shahriar A., Kaneti, Yusuf Valentino, Yamauchi, Yusuke and Masud, Mostafa Kamal (2022). Hydrogel nanoarchitectonics: an evolving paradigm for ultrasensitive biosensing. Small, 18 (26) 2107571, 2107571. doi: 10.1002/smll.202107571

  • Masud, Mostafa Kamal, Na, Jongbeom, Lin, Tzu-En, Malgras, Victor, Preet, Anant, Ibn Sina, Abu Ali, Wood, Kathleen, Billah, Mutasim, Kim, Jeonghun, You, Jungmok, Kani, Kenya, Whitten, Andrew E., Salomon, Carlos, Nguyen, Nam-Trung, Shiddiky, Muhammad J.A., Trau, Matt, Hossain, MdShahriar A. and Yamauchi, Yusuke (2020). Nanostructured mesoporous gold biosensor for microRNA detection at attomolar level. Biosensors and Bioelectronics, 168 112429, 1-9. doi: 10.1016/j.bios.2020.112429

  • Masud, Mostafa Kamal, Na, Jongbeom, Younus, Muhammad, Hossain, Md. Shahriar A., Bando, Yoshio, Shiddiky, Muhammad J. A. and Yamauchi, Yusuke (2019). Superparamagnetic nanoarchitectures for disease-specific biomarker detection. Chemical Society Reviews, 48 (24), 5717-5751. doi: 10.1039/c9cs00174c

  • Masud, Mostafa Kamal, Yadav, Sharda, Islam, Md. Nazmul, Nguyen, Nam-Trung, Salomon, Carlos, Kline, Richard, Alamri, Hatem R., Alothman, Zeid A., Yamauchi, Yusuke, Hossain, Md. Shahriar A. and Shiddiky, Muhammad J. A. (2017). Gold-loaded nanoporous ferric oxide nanocubes with peroxidase-mimicking activity for electrocatalytic and colorimetric Detection of autoantibody. Analytical Chemistry, 89 (20), 11005-11013. doi: 10.1021/acs.analchem.7b02880

  • Masud, Mostafa Kamal, Islam, Md. Nazmul, Haque, Md. Hakimul, Tanaka, Shunsuke, Gopalan, Vinod, Alici, Gursel, Nguyen, Nam-Trung, Lam, Alfred K., Hossain, Md. Shahriar A., Yamauchi, Yusuke and Shiddiky, Muhammad J. A. (2017). Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA. Chemical Communications, 53 (58), 8231-8234. doi: 10.1039/c7cc04789d

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Featured Publications

  • Kang, Yunqing, Masud, Mostafa Kamal, Guo, Yanna, Zhao, Yingji, Nishat, Zakia Sultana, Zhao, Jingjing, Jiang, Bo, Sugahara, Yoshiyuki, Pejovic, Tanja, Morgan, Terry, Hossain, Md Shahriar A., Li, Hexing, Salomon, Carlos, Asahi, Toru and Yamauchi, Yusuke (2023). Au-loaded superparamagnetic mesoporous bimetallic CoFeB nanovehicles for sensitive autoantibody detection. ACS Nano, 17 (4), 3346-3357. doi: 10.1021/acsnano.2c07694

  • Nishat, Zakia Sultana, Hossain, Tanvir, Islam, Md. Nazmul, Phan, Hoang‐Phuong, Wahab, Md A., Moni, Mohammad Ali, Salomon, Carlos, Amin, Mohammed A., Sina, Abu Ali Ibn, Hossain, Md Shahriar A., Kaneti, Yusuf Valentino, Yamauchi, Yusuke and Masud, Mostafa Kamal (2022). Hydrogel nanoarchitectonics: an evolving paradigm for ultrasensitive biosensing. Small, 18 (26) 2107571, 2107571. doi: 10.1002/smll.202107571

  • Masud, Mostafa Kamal, Na, Jongbeom, Lin, Tzu-En, Malgras, Victor, Preet, Anant, Ibn Sina, Abu Ali, Wood, Kathleen, Billah, Mutasim, Kim, Jeonghun, You, Jungmok, Kani, Kenya, Whitten, Andrew E., Salomon, Carlos, Nguyen, Nam-Trung, Shiddiky, Muhammad J.A., Trau, Matt, Hossain, MdShahriar A. and Yamauchi, Yusuke (2020). Nanostructured mesoporous gold biosensor for microRNA detection at attomolar level. Biosensors and Bioelectronics, 168 112429, 1-9. doi: 10.1016/j.bios.2020.112429

  • Masud, Mostafa Kamal, Na, Jongbeom, Younus, Muhammad, Hossain, Md. Shahriar A., Bando, Yoshio, Shiddiky, Muhammad J. A. and Yamauchi, Yusuke (2019). Superparamagnetic nanoarchitectures for disease-specific biomarker detection. Chemical Society Reviews, 48 (24), 5717-5751. doi: 10.1039/c9cs00174c

  • Masud, Mostafa Kamal, Yadav, Sharda, Islam, Md. Nazmul, Nguyen, Nam-Trung, Salomon, Carlos, Kline, Richard, Alamri, Hatem R., Alothman, Zeid A., Yamauchi, Yusuke, Hossain, Md. Shahriar A. and Shiddiky, Muhammad J. A. (2017). Gold-loaded nanoporous ferric oxide nanocubes with peroxidase-mimicking activity for electrocatalytic and colorimetric Detection of autoantibody. Analytical Chemistry, 89 (20), 11005-11013. doi: 10.1021/acs.analchem.7b02880

  • Masud, Mostafa Kamal, Islam, Md. Nazmul, Haque, Md. Hakimul, Tanaka, Shunsuke, Gopalan, Vinod, Alici, Gursel, Nguyen, Nam-Trung, Lam, Alfred K., Hossain, Md. Shahriar A., Yamauchi, Yusuke and Shiddiky, Muhammad J. A. (2017). Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA. Chemical Communications, 53 (58), 8231-8234. doi: 10.1039/c7cc04789d

Book Chapter

  • Arifuzzaman, Md, Kamal Masud, Mostafa, Ahmed, Asif, Morsaline Billah, Md and Nazmul Islam, Md (2023). Electrochemical biosensor for cancer biomarkers detection. Current cancer biomarkers. (pp. 349-371) Sharjah, U.A.E: Bentham Science Publishers. doi: 10.2174/9789815079364123010017

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision