Dr Kelly Walton

Senior Research Fellow

School of Biomedical Sciences
Faculty of Medicine

Overview

Publications

  • Walton, Kelly L., Goney, Monica P., Peppas, Zoe, Stringer, Jessica M., Winship, Amy, Hutt, Karla, Goodchild, Georgia, Maskey, Shreya, Chan, Karen L., Brûlé, Emilie, Bernard, Daniel J., Stocker, William A. and Harrison, Craig A. (2022). Inhibin inactivation in female mice leads to elevated FSH levels, ovarian over-stimulation, and pregnancy loss. Endocrinology, 163 (4) bqac025. doi: 10.1210/endocr/bqac025

  • Houston, Brendan J, O’Connor, Anne E, Wang, Degang, Goodchild, Georgia, Merriner, D Jo, Luan, Haitong, Conrad, Don F, Nagirnaja, Liina, Aston, Kenneth I, Kliesch, Sabine, Wyrwoll, Margot J, Friedrich, Corinna, Tüttelmann, Frank, Harrison, Craig, O’Bryan, Moira K and Walton, Kelly (2022). Human INHBB gene variant (c.1079T>C:p.Met360Thr) alters testisgerm cell content, but does not impact fertility in mice. Endocrinology, 163 (3) bqab269. doi: 10.1210/endocr/bqab269

  • Brûlé, Emilie, Wang, Ying, Li, Yining, Lin, Yeu-Farn, Zhou, Xiang, Ongaro, Luisina, Alonso, Carlos A. I., Buddle, Evan R. S., Schneyer, Alan L., Byeon, Chang-Hyeock, Hinck, Cynthia S., Mendelev, Natalia, Russell, John P., Cowan, Mitra, Boehm, Ulrich, Ruf-Zamojski, Frederique, Zamojski, Michel, Andoniadou, Cynthia L., Sealfon, Stuart C., Harrison, Craig A., Walton, Kelly L., Hinck, Andrew P. and Bernard, Daniel J. (2021). TGFBR3L is an inhibin B co-receptor that regulates female fertility. Science Advances, 7 (51) eabl4391, eabl4391. doi: 10.1126/sciadv.abl4391

View all Publications

Publications

Journal Article

  • Walton, Kelly L., Goney, Monica P., Peppas, Zoe, Stringer, Jessica M., Winship, Amy, Hutt, Karla, Goodchild, Georgia, Maskey, Shreya, Chan, Karen L., Brûlé, Emilie, Bernard, Daniel J., Stocker, William A. and Harrison, Craig A. (2022). Inhibin inactivation in female mice leads to elevated FSH levels, ovarian over-stimulation, and pregnancy loss. Endocrinology, 163 (4) bqac025. doi: 10.1210/endocr/bqac025

  • Houston, Brendan J, O’Connor, Anne E, Wang, Degang, Goodchild, Georgia, Merriner, D Jo, Luan, Haitong, Conrad, Don F, Nagirnaja, Liina, Aston, Kenneth I, Kliesch, Sabine, Wyrwoll, Margot J, Friedrich, Corinna, Tüttelmann, Frank, Harrison, Craig, O’Bryan, Moira K and Walton, Kelly (2022). Human INHBB gene variant (c.1079T>C:p.Met360Thr) alters testisgerm cell content, but does not impact fertility in mice. Endocrinology, 163 (3) bqab269. doi: 10.1210/endocr/bqab269

  • Brûlé, Emilie, Wang, Ying, Li, Yining, Lin, Yeu-Farn, Zhou, Xiang, Ongaro, Luisina, Alonso, Carlos A. I., Buddle, Evan R. S., Schneyer, Alan L., Byeon, Chang-Hyeock, Hinck, Cynthia S., Mendelev, Natalia, Russell, John P., Cowan, Mitra, Boehm, Ulrich, Ruf-Zamojski, Frederique, Zamojski, Michel, Andoniadou, Cynthia L., Sealfon, Stuart C., Harrison, Craig A., Walton, Kelly L., Hinck, Andrew P. and Bernard, Daniel J. (2021). TGFBR3L is an inhibin B co-receptor that regulates female fertility. Science Advances, 7 (51) eabl4391, eabl4391. doi: 10.1126/sciadv.abl4391

  • Hart, Kaitlin N., Stocker, William A., Nagykery, Nicholas G., Walton, Kelly L., Harrison, Craig A., Donahoe, Patricia K., Pépin, David and Thompson, Thomas B. (2021). Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family. Proceedings of the National Academy of Sciences of the United States of America, 118 (26) e2104809118. doi: 10.1073/pnas.2104809118

  • Hagg, Adam, Kharoud, Swati, Goodchild, Georgia, Goodman, Craig A., Chen, Justin L., Thomson, Rachel E., Qian, Hongwei, Gregorevic, Paul, Harrison, Craig A. and Walton, Kelly L. (2020). TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass. Frontiers in Physiology, 11 560225. doi: 10.3389/fphys.2020.560225

  • Jaillard, Sylvie, Bell, Katrina, Akloul, Linda, Walton, Kelly, McElreavy, Kenneth, Stocker, William A., Beaumont, Marion, Harrisson, Craig, Jääskeläinen, Tiina, Palvimo, Jorma J., Robevska, Gorjana, Launay, Erika, Satié, Anne-Pascale, Listyasari, Nurin, Bendavid, Claude, Sreenivasan, Rajini, Duros, Solène, van den Bergen, Jocelyn, Henry, Catherine, Domin-Bernhard, Mathilde, Cornevin, Laurence, Dejucq-Rainsford, Nathalie, Belaud-Rotureau, Marc-Antoine, Odent, Sylvie, Ayers, Katie L., Ravel, Célia, Tucker, Elena J. and Sinclair, Andrew H. (2020). New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing. Maturitas, 141, 9-19. doi: 10.1016/j.maturitas.2020.06.004

  • Goney, Monica P, Wilce, Matthew C J, Wilce, Jacqueline A, Stocker, William A, Goodchild, Georgia M, Chan, Karen L, Harrison, Craig A and Walton, Kelly L (2020). Engineering the Ovarian Hormones Inhibin A and Inhibin B to Enhance Synthesis and Activity. Endocrinology, 161 (8). doi: 10.1210/endocr/bqaa099

  • Stocker, William A., Walton, Kelly L., Richani, Dulama, Chan, Karen L., Beilby, Kiri H., Finger, Bethany J., Green, Mark P., Gilchrist, Robert B. and Harrison, Craig A. (2020). A variant of human growth differentiation factor-9 that improves oocyte developmental competence. Journal of Biological Chemistry, 295 (23), 7981-7991. doi: 10.1074/jbc.ra120.013050

  • Walton, Kelly L, Chen, Justin L, Arnold, Quinn, Kelly, Emily, La, Mylinh, Lu, Louis, Lovrecz, George, Hagg, Adam, Colgan, Timothy D, Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A (2019). Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice. Endocrinology, 160 (10), 2417-2426. doi: 10.1210/en.2019-00257

  • Riepsamen, Angelique H., Chan, Karen, Lien, Shelly, Sweeten, Prudence, Donoghoe, Mark W., Walker, Glenda, Fraison, Eloïse H. J., Stocker, William A., Walton, Kelly L., Harrison, Craig A., Ledger, William L., Robertson, David M. and Gilchrist, Robert B. (2019). Serum concentrations of oocyte-secreted factors BMP15 and GDF9 during IVF and in women with reproductive pathologies. Endocrinology, 160 (10), 2298-2313. doi: 10.1210/en.2019-00264

  • Bouty, Aurore, Walton, Kelly, Listyasari, Nurin Aisyiyah, Robevska, Gorjana, Van den Bergen, Jocelyn, Santosa, Ardy, Faradz, Sultana M H, Harrison, Craig, Ayers, Katie L and Sinclair, Andrew H (2019). Functional characterization of two new variants in the bone morphogenetic protein 7 prodomain in two pairs of monozygotic twins with hypospadias. Journal of the Endocrine Society, 3 (4), 814-824. doi: 10.1210/js.2018-00333

  • Walker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A. and Thompson, Thomas B. (2018). Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, 115 (5), E866-E875. doi: 10.1073/pnas.1714622115

  • Chen, Justin L., Walton, Kelly L., Hagg, Adam, Colgan, Timothy D., Johnson, Katharine, Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2017). Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), E5266-E5275. doi: 10.1073/pnas.1620013114

  • Walker, Ryan G., Czepnik, Magdalena, Goebel, Erich J., McCoy, Jason C., Vujic, Ana, Cho, Miook, Oh, Juhyun, Aykul, Senem, Walton, Kelly L., Schang, Gauthier, Bernard, Daniel J., Hinck, Andrew P., Harrison, Craig A., Martinez-Hackert, Erik, Wagers, Amy J., Lee, Richard T. and Thompson, Thomas B. (2017). Structural basis for potency differences between GDF8 and GDF11. BMC Biology, 15 (1) 19. doi: 10.1186/s12915-017-0350-1

  • Patino, Liliana C., Walton, Kelly L., Mueller, Thomas D., Johnson, Katharine E., Stocker, William, Richani, Dulama, Agapiou, David, Gilchrist, Robert B., Laissue, Paul and Harrison, Craig A. (2017). BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9. Journal of Clinical Endocrinology and Metabolism, 102 (3), 1009-1019. doi: 10.1210/jc.2016-3503

  • Coulson, Rhiannon, Liew, Seng H., Connelly, Angela A., Yee, Nicholas S., Deb, Siddhartha, Kumar, Beena, Vargas, Ana C., O'Toole, Sandra A., Parslow, Adam C., Poh, Ashleigh, Putoczki, Tracy, Morrow, Riley J., Alorro, Mariah, Lazarus, Kyren A., Yeap, Evie F.W., Walton, Kelly L., Harrison, Craig A., Hannan, Natalie J., George, Amee J., Clyne, Colin D., Ernst, Matthias, Allen, Andrew M. and Chand, Ashwini L. (2017). The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma. Oncotarget, 8 (12), 18640-18656. doi: 10.18632/oncotarget.15553

  • Chen, Justin L., Walton, Kelly L., Qian, Hongwei, Colgan, Timothy D., Hagg, Adam, Watt, Matthew J., Harrison, Craig A. and Gregorevic, Paul (2016). Differential effects of IL6 and activin A in the development of cancer-associated cachexia. Cancer Research, 76 (18), 5372-5382. doi: 10.1158/0008-5472.CAN-15-3152

  • Chen, Justin L., Walton, Kelly L., Al-Musawi, Sara L., Kelly, Emily K., Qian, Hongwei, La, Mylinh, Lu, Louis, Lovrecz, George, Ziemann, Mark, Lazarus, Ross, El-Osta, Assam, Gregorevic, Paul and Harrison, Craig A. (2015). Development of novel activin-targeted therapeutics. Molecular Therapy, 23 (3), 434-444. doi: 10.1038/mt.2014.221

  • Tournier, Isabelle, Marlin, Régine, Walton, Kelly, Charbonnier, Françoise, Coutant, Sophie, Théry, Jean-Christophe, Charbonnier, Camille, Spurrell, Cailyn, Vezain, Myriam, Ippolito, Lorena, Bougeard, Gaëlle, Roman, Horace, Tinat, Julie, Sabourin, Jean-Christophe, Stoppa-Lyonnet, Dominique, Caron, Olivier, Bressac-de Paillerets, Brigitte, Vaur, Dominique, King, Mary-Claire, Harrison, Craig and Frebourg, Thierry (2014). Germline mutations of inhibins in early-onset ovarian epithelial tumors. Human Mutation, 35 (3), 294-297. doi: 10.1002/humu.22489

  • Simpson, Courtney M., Stanton, Peter G., Walton, Kelly L., Chan, Karen L., Ritter, Lesley J., Gilchrist, Robert B. and Harrison, Craig A. (2012). Activation of latent human GDF9 by a single residue change (Gly391Arg) in the mature domain. Endocrinology, 153 (3), 1301-1310. doi: 10.1210/en.2011-1632

  • Makanji, Yogeshwar, Walton, Kelly L., Chan, Karen L., Gregorevic, Paul, Robertson, David M. and Harrison, Craig A. (2011). Generation of a specific activin antagonist by modification of the activin A propeptide. Endocrinology, 152 (10), 3758-3768. doi: 10.1210/en.2011-1052

  • Walton, Kelly L., Makanji, Yogeshwar, Chen, Justin, Wilce, Matthew C., Chan, Karen L., Robertson, David M. and Harrison, Craig A. (2010). Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-β1 complex. Journal of Biological Chemistry, 285 (22), 17029-17037. doi: 10.1074/jbc.M110.110288

  • Walton, Kelly L., Makanji, Yogeshwar, Wilce, Matthew C., Chan, Karen L., Robertson, David M. and Harrison, Craig A. (2009). A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor β(TGFβ) ligands. Journal of Biological Chemistry, 284 (14), 9311-9320. doi: 10.1074/jbc.M808763200

  • Makanji, Yogeshwar, Walton, Kelly L., Wilce, Matthew C., Chan, Karen L., Robertson, David M. and Harrison, Craig A. (2008). Suppression of inhibin A biological activity by alterations in the binding site for betaglycan. Journal of Biological Chemistry, 283 (24), 16743-16751. doi: 10.1074/jbc.M801045200

Grants (Administered at UQ)