Dr Frederik Steyn

Senior Lecturer - Anatomy & Patholo

School of Biomedical Sciences
Faculty of Medicine
f.steyn@uq.edu.au
+61 7 334 65555

Overview

Dr Steyn started his career as a Biomedical Researcher conducting mechanistic studies that define hypothalamic integration of energy homeostasis, growth and reproduction. He developed transformative methodologies that are the industry gold-standard for the assessment of patterned hormone release in murine models of disease. In 2015, Dr Steyn expanded this research focus to conduct studies to improve our understanding of neurodegenerative disease. He co-pioneered methodologies for improved assessment of energy expenditure in patients with Motor Neurone Disease and developed a research platform that has received traction for improved detection of hypermetabolism in neurodegenerative disease. Dr Steyn currently oversees a pre-clinical and clinical research program that aims to increase our understanding of the physiological response to disease, and specifically neurodegenerative diseases that are defined by the loss of upper and lower motor neurones. Within this program, he conducts studies on the role of metabolism on the progression of neurodegenerative disease (MEND-MND), and the effects of loss of appetite and impaired body weight regulation (EATT4MND) quality of life and disease progression.

Research Impacts

I have developed a translational research focus where I am assessing the role of altered growth and metabolism on the rate of progression of neurodegenerative disease, and in particular Motor Neurone Disease (MND). Through patient and animal directed studies I seek to repurpose endocrine and metabolic-directed treatment strategies to slow disease progression and improve quality of life for those currently living with MND.

Qualifications

  • Doctor of Philosophy, University of Otago

Publications

  • Chang, Jeryn, Steyn, Frederik, Ngo, Shyuan, Henderson, Robert, Guo, Christine, Bollmann, Steffen, Fripp, Jurgen, Barth, Markus and Shaw, Thomas (2022). Open-Source Hypothalamic-ForniX (OSHy-X) Atlases and Segmentation Tool for 3T and 7T. Journal of Open Source Software, 7 (76), 4368. doi: 10.21105/joss.04368

  • Ding, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5

  • Hop, Paul J., Zwamborn, Ramona A.J., Hannon, Eilis, Shireby, Gemma L., Nabais, Marta F., Walker, Emma M., van Rheenen, Wouter, van Vugt, Joke J.F.A., Dekker, Annelot M., Westeneng, Henk-Jan, Tazelaar, Gijs H.P., van Eijk, Kristel R., Moisse, Matthieu, Baird, Denis, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Ticozzi, Nicola, Ratti, Antonia, Cooper-Knock, Jonathan, Morrison, Karen E., Shaw, Pamela J., Basak, A. Nazli, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Canosa, Antonio, Brunetti, Maura, Grassano, Maurizio, Gotkine, Marc ... Brain MEND Consortium (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine, 14 (633) eabj0264, 1-15. doi: 10.1126/scitranslmed.abj0264

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Holdom, Cory J., Steyn, Frederik J., Henderson, Robert D., McCombe, Pamela A., Rogers, Mary-Louise and Ngo, Shyuan T. (2022). Biofluid biomarkers of amyotrophic lateral sclerosis. Neurodegenerative diseases biomarkers: towards translating research to clinical practice. (pp. 263-306) edited by Philip V. Peplow, Bridget Martinez and Thomas A. Gennarelli. New York, United States: Springer . doi: 10.1007/978-1-0716-1712-0_11

  • Ahmed, Rebekah M., Steyn, Frederik and Dupuis, Luc (2021). Hypothalamus and weight loss in amyotrophic lateral sclerosis. Handbook of clinical neurology. (pp. 327-338) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-820107-7.00020-3

  • Ngo, Shyuan T., Steyn, Frederik J., McCombe, Pamela A. and Borges, Karin (2015). High Caloric diets for amyotrophic lateral sclerosis. Bioactive nutraceuticals and dietary supplements in neurological and brain disease: prevention and therapy. (pp. 355-361) edited by Ronald Ross Watson and Victor R. Preedy. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-411462-3.00036-9

  • Steyn, Frederik J. and Chen, Chen (2013). Adiponectin. Handbook of biologically active peptides. (pp. 983-989) edited by Abba J. Kastin. Amsterdam, Netherlands: Academic Press/Elsevier. doi: 10.1016/B978-0-12-385095-9.00130-5

Journal Article

Conference Publication

Other Outputs

  • Ngo, Shyuan, Power, Dominique, Andersen, Stacey, Taherian Fard, Atefeh, Chang, Jeryn and Steyn, Frederik (2022). snrRNA-seq_muscle_dataset. The University of Queensland. (Dataset) doi: 10.48610/0106c8e

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision