Dr Philip Mosley

Honorary Senior Fellow

Queensland Brain Institute

Honorary Senior Fellow

Royal Brisbane Clinical Unit
Faculty of Medicine

Overview

Dr Philip Mosley studied at the University of Oxford and obtained a masters degree in physiological sciences and a degree in medicine. He was also captain of the university boxing team and was awarded two full 'Blues'. He worked as a junior doctor in Manchester before moving to Australia to complete his specialist training in psychiatry.

Dr Mosley is a Fellow of the Royal Australian and New Zealand College of Psychiatry (RANZCP) and has completed an advanced certificate in Consultation-Liaison Psychiatry. As part of his training he also undertook a 2-year neuropsychiatry fellowship at the Royal Brisbane and Women’s Hospital (RBWH) and the Asia-Pacific Centre for Neuromodulation (APCN) at the University of Queensland. Currently, Dr Mosley works as a member of the deep brain stimulation (DBS) team at St Andrew's War Memorial Hospital, Brisbane, runs a private neuropsychiatry practice and also provides a consultation-liaison psychiatry service to the neurology, medical and surgical wards. Dr Mosley's private practice is focussed on neurodegenerative disease, movement disorders and head injury.

Dr Mosley is an active clinician-scientist with appointments at the QIMR Berghofer Medical Research Institute, Queensland Brain Institute and CSIRO. He completed his PhD in neuroscience in 2019 under the supervision of Professor Michael Breakspear. He published eleven peer-reviewed manuscripts and received the UQ Dean's Award for outstanding thesis. Dr Mosley has been the chief investigator in a study of the neuropsychiatric effects of DBS for Parkinson’s disease, in a study of medicinal cannabis for Tourette’s syndrome, a lead investigator in a clinical trial of DBS for obsessive-compulsive disorder and anorexia nervosa, as well as a clinical fellow in a neuroimaging study of Alzheimer’s disease. He has won prizes from the RANZCP in Old Age Psychiatry and Consultation-Liaison Psychiatry, and he has received research funding from the RBWH Foundation, the RANZCP Young Investigator Grant, Parkinson’s Queensland and Wesley Medical Research. Dr Mosley was awarded an ‘Advance Queensland’ Early Career Fellowship for his Parkinson's disease research and won the postgraduate medal from the Australian Society for Medical Research for findings arising from this project. In 2020, he won the Early Career Psychiatrist award from the RANZCP, which is presented to the fellow producing the most significant piece of research in the five years since fellowship.

If you wish to contact Dr Mosley regarding a clinical matter, please do so via his neuropsychiatry clinic (Neurosciences Queensland) telephone: 07 3839 3688 or email: admin@nsqld.com.au.

Research Impacts

Dr Mosley is one of the most experienced psychiatrists in the world with regards to the practice of deep brain stimulation (DBS) and has been embedded as a psychiatrist in the DBS service in Brisbane since 2013. This centre is the largest in Australia and one of the largest worldwide (1200 devices implanted). Dr Mosley has improved the neuropsychiatric safety of DBS for Parkinson’s disease through individualised assessments of brain connectivity and stimulation field distribution. His rich dataset has been shared with European and US collaborators. During his PhD in neuroscience, Dr Mosley demarcated brain networks responsible for changes in mood after DBS and used mathematical modelling of human behaviour to discriminate those at risk of postoperative psychiatric complications. His work translates clinically to more accurate and effective use of neuromodulation, based on targeted recruitment of key neuronal pathways. Applying these methods to treatment-resistant obsessive-compulsive disorder, Dr Mosley characterised a brain connectivity fingerprint associated with clinically-significant response to DBS. This was a landmark Australian trial (Reg. U1111-1146-0992), establishing DBS as a viable treatment option for those with intractable symptoms. Positive outcomes from this sham-controlled trial have led to the first Australian trial of DBS for severe and enduring anorexia nervosa (Reg. U1111-1219-9348).

Completed Projects:

  1. Defining brain networks mediating psychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease.
  2. Predictors of caregiver burden after subthalamic deep brain stimulation for Parkinson's disease.
  3. Psychological interventions for caregivers after subthalamic deep brain stimulation for Parkinson's disease.
  4. Deep brain stimulation of the nucleus accumbens for severe, treatment-resistant, obsessive-compulsive disorder.
  5. A randomised, double-blind, placebo-controlled crossover trial of medicinal cannabis for Tourette's syndrome.
  6. Neuroimaging biomarkers of early Alzheimer's disease.

Current Projects:

  1. Deep brain stimulation of the nucleus accumbens for severe and enduring anorexia nervosa (recruiting).
  2. Transcranial focussed ultrasound for severe obsessive-compulsive disorder (pending funding outcome).

Publications

  • Bivol, Svetlana, Mellick, George D., Gratten, Jacob, Parker, Richard, Mulcahy, Aoibhe, Mosley, Philip E., Poortvliet, Peter C., Campos, Adrian I., Mitchell, Brittany L., Garcia-Marin, Luis M., Cross, Simone, Ferguson, Mary, Lind, Penelope A., Loesch, Danuta Z., Visscher, Peter M., Medland, Sarah E., Scherzer, Clemens R., Martin, Nicholas G. and Rentería, Miguel E. (2022). Australian Parkinson’s Genetics Study (APGS): pilot (n=1532). BMJ Open, 12 (2) e052032, e052032. doi: 10.1136/bmjopen-2021-052032

  • Borne, Léonie, Lupton, Michelle K., Guo, Christine, Mosley, Philip, Adam, Robert, Ceslis, Amelia, Bourgeat, Pierrick, Fazlollahi, Amir , Maruff, Paul, Rowe, Christopher C., Masters, Colin L., Fripp, Jurgen , Robinson, Gail A. and Breakspear, Michael (2022). A snapshot of brain and cognition in healthy mid-life and older adults. bioRxiv. doi: 10.1101/2022.01.20.476706

  • Baldermann, Juan Carlos, Schueller, Thomas, Kohl, Sina, Voon, Valerie, Li, Ningfei, Hollunder, Barbara, Figee, Martijn, Haber, Suzanne N., Sheth, Sameer A., Mosley, Philip E., Huys, Daniel, Johnson, Kara A., Butson, Christopher, Ackermans, Linda, Vlis, Tim Bouwens van der, Leentjens, Albert F. G., Barbe, Michael, Visser-Vandewalle, Veerle, Kuhn, Jens and Horn, Andreas (2021). Connectomic deep brain stimulation for obsessive-compulsive disorder. Biological Psychiatry, 90 (10), 678-688. doi: 10.1016/j.biopsych.2021.07.010

View all Publications

Publications

Book Chapter

  • Mosley, Philip E. and Akram, Harith (2021). Neuropsychiatric effects of subthalamic deep brain stimulation. Handbook of clinical neurology. (pp. 417-431) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-820107-7.00026-4

  • Mosley, Philip and Lyness, Jeffrey (2014). Physical co-morbidity with mood disorders. The Oxford handbook of clinical geropsychology. (pp. 436-469) edited by Nancy A. Pachana and Ken Laidlaw. Oxford, United Kingom: Oxford University Press.

  • Mosley, Philip E. and Laidlaw, Ken (2014). Physical comorbidity with mood disorders. The Oxford handbook of clinical geropsychology. edited by Philip E. Mosley and Jeffrey Lyness. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/oxfordhb/9780199663170.013.036

  • Mosley, Philip E. (2009). Supplementation in bodybuilding: Pseudoscience, marketing and muscle dysmorphia. Handbook of Sports Psychology. (pp. 241-258) Nova Science Publishers, Inc..

Journal Article

Conference Publication

Other Outputs