The University of Queensland

Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization

Larsson, Elin, Morén, Björn, McMahon, Kerrie-Ann, Parton, Robert G. and Lundmark, Richard (2023). Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization. Journal of Cell Biology, 222 (4) e202205122. doi: 10.1083/jcb.202205122

Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2

Wu, Yeping, Lim, Ye-Wheen, Stroud, David A., Martel, Nick, Hall, Thomas E., Lo, Harriet P., Ferguson, Charles, Ryan, Michael T., McMahon, Kerrie-Ann and Parton, Robert G. (2023). Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2. Developmental Cell, 58 (5), 376-397.e4. doi: 10.1016/j.devcel.2023.02.004

Proximity dependent biotin labelling in zebrafish for proteome and interactome profiling

Xiong, Zherui, Lo, Harriet P., McMahon, Kerrie-Ann, Parton, Robert G. and Hall, Thomas E. (2021). Proximity dependent biotin labelling in zebrafish for proteome and interactome profiling. Bio-protocol, 11 (19) e4178, e4178. doi: 10.21769/BIOPROTOC.4178

Key phases in the formation of caveolae

Parton, Robert G., Tillu, Vikas, McMahon, Kerrie-Ann and Collins, Brett M. (2021). Key phases in the formation of caveolae. Current Opinion in Cell Biology, 71, 7-14. doi: 10.1016/j.ceb.2021.01.009

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

McMahon, Kerrie-Ann, Stroud, David A., Gambin, Yann, Tillu, Vikas, Bastiani, Michele, Sierecki, Emma, Polinkovsky, Mark E., Hall, Thomas E., Gomez, Guillermo A., Wu, Yeping, Parat, Marie-Odile, Martel, Nick, Lo, Harriet P., Khanna, Kum Kum, Alexandrov, Kirill, Daly, Roger, Yap, Alpha, Ryan, Michael T. and Parton, Robert G. (2021). Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. eLife, 10 e61407, 1-35. doi: 10.7554/elife.61407

In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish

Xiong, Zherui, Lo, Harriet P., McMahon, Kerrie-Ann, Martel, Nick, Jones, Alun, Hill, Michelle M., Parton, Robert G. and Hall, Thomas E. (2021). In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish. eLife, 10 e64631, 1-21. doi: 10.7554/elife.64631

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

Tillu, Vikas A., Rae, James, Gao, Ya, Ariotti, Nicholas, Floetenmeyer, Matthias, Kovtun, Oleksiy, McMahon, Kerrie-Ann, Chaudhary, Natasha, Parton, Robert G. and Collins, Brett M. (2021). Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation. Nature Communications, 12 (1) 931, 931. doi: 10.1038/s41467-021-21035-4

Caveolae: Formation, dynamics, and function

Parton, Robert G., McMahon, Kerrie-Ann and Wu, Yeping (2020). Caveolae: Formation, dynamics, and function. Current Opinion in Cell Biology, 65, 8-16. doi: 10.1016/j.ceb.2020.02.001

Mapping interactions among cell-free expressed Zirka virus proteins

Varasteh Moradi, Shayli, Gagoski, Dejan, Mureev, Sergey, Walden, Patricia, McMahon, Kerrie-Ann, Parton, Robert G., Johnston, Wayne A. and Alexandrov, Kirill (2020). Mapping interactions among cell-free expressed Zirka virus proteins. Journal of Proteome Research, 19 (4) acs.jproteome.9b00771, 1522-1532. doi: 10.1021/acs.jproteome.9b00771

A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure

Pu, Wenjun, Qiu, Jiawen, Nassar, Zeyad D., Shaw, Paul N., McMahon, Kerrie‐Ann, Ferguson, Charles, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie‐Odile (2020). A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure. Journal of Cellular and Molecular Medicine, 24 (6) jcmm.15076, 3724-3738. doi: 10.1111/jcmm.15076

Caveolae control contractile tension for epithelia to eliminate tumor cells

Teo, Jessica L., Gomez, Guillermo A., Weeratunga, Saroja, Davies, Elizabeth M., Noordstra, Ivar, Budnar, Srikanth, Katsuno-Kambe, Hiroko, McGrath, Meagan J., Verma, Suzie, Tomatis, Vanesa, Acharya, Bipul R., Balasubramaniam, Lakshmi, Templin, Rachel M., McMahon, Kerrie-Ann, Lee, Yoke Seng, Ju, Robert J., Stebhens, Samantha J., Ladoux, Benoit, Mitchell, Christina A., Collins, Brett M., Parton, Robert G. and Yap, Alpha S. (2020). Caveolae control contractile tension for epithelia to eliminate tumor cells. Developmental Cell, 54 (1), 75-91.e7. doi: 10.1016/j.devcel.2020.05.002

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis

McMahon, Kerrie-Ann, Wu, Yeping, Gambin, Yann, Sierecki, Emma, Tillu, Vikas A., Hall, Thomas, Martel, Nick, Okano, Satomi, Moradi, Shayli Varasteh, Ruelcke, Jayde E., Ferguson, Charles, Yap, Alpha S., Alexandrov, Kirill, Hill, Michelle M. and Parton, Robert G. (2019). Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis. Nature Communications, 10 (1) 3279, 3279. doi: 10.1038/s41467-019-11111-1

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

Pu, Wenjun, Nassar, Zeyad D., Khabbazi, Samira, Xie, Nan, McMahon, Kerrie-Ann, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie-Odile (2019). Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1. Journal of Neuro-Oncology, 143 (2), 207-220. doi: 10.1007/s11060-019-03161-8

A variable undecad repeat domain in cavin1 regulates caveola formation and stability

Tillu, Vikas A., Lim, Ye-Wheen, Kovtun, Oleksiy, Mureev, Sergey, Ferguson, Charles, Bastiani, Michele, McMahon, Kerrie-Ann, Lo, Harriet P., Hall, Thomas E., Alexandrov, Kirill, Collins, Brett M. and Parton, Robert G. (2018). A variable undecad repeat domain in cavin1 regulates caveola formation and stability. EMBO Reports, 19 (9) e45775. doi: 10.15252/embr.201845775

Caveolin 1 restricts Group A Streptococcus invasion of nonphagocytic host cells

Lim, Jin Yan, Barnett, Timothy C., Bastiani, Michele, McMahon, Kerrie-Ann, Ferguson, Charles, Webb, Richard I., Parton, Robert G. and Walker, Mark J. (2017). Caveolin 1 restricts Group A Streptococcus invasion of nonphagocytic host cells. Cellular microbiology, 19 (12) e12772, 1-16. doi: 10.1111/cmi.12772

Modular detection of GFP-labeled proteins for rapid screening by electron microscopy in cells and organisms

Ariotti, Nicholas, Hall, Thomas, Rae, James, Ferguson, Charles, McMahon, Kerrie-Ann, Martel, Nick, Webb, Robyn E., Webb, Richard I., Teasdale, Rohan D. and Parton, Robert G. (2015). Modular detection of GFP-labeled proteins for rapid screening by electron microscopy in cells and organisms. Developmental Cell, 35 (4), 513-525. doi: 10.1016/j.devcel.2015.10.016

A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation

Tillu, Vikas A., Kovtun, Oleksiy, McMahon, Kerrie-Ann, Collins, Brett M. and Parton, Robert G. (2015). A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation. Molecular Biology of the Cell, 26 (20), 3561-3569. doi: 10.1091/mbc.E15-06-0359

Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy

Shi, Yin, Tan, Shi-Hao, Ng, Shukie, Zhou, Jing, Yang, Na-Di, Khoo, Gi-Bang, McMahon, Kerrie-Ann, Parton, Robert G., Hill, Michelle, del Pozo, Miguel A., Kim, You-Sun and Shen, Han-Ming (2015). Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy. Autophagy, 11 (5), 769-784. doi: 10.1080/15548627.2015.1034411

Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis

Chaudhary, Natasha, Gomez, Guillermo A., Howes, Mark T., Lo, Harriet P., McMahon, Kerrie-Ann, Rae, James A., Schieber, Nicole L., Hill, Michelle M., Gaus, Katharina, Yap, Alpha S. and Parton, Robert G. (2014). Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis. PLoS Biology, 12 (4) e1001832, e1001832.1-e1001832.20. doi: 10.1371/journal.pbio.1001832

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

Gambin, Yann, Ariotti, Nicholas, McMahon, Kerrie-Ann, Bastiani, Michele, Sierecki, Emma, Kovtun, Oleksiy, Polinkovsky, Mark E., Magenau, Astrid, Jung, WooRam, Okano, Satomi, Zhou, Yong, Leneva, Natalya, Mureev, Sergey, Johnston, Wayne, Gaus, Katharina, Hancock, John F., Collins, Brett M., Alexandrov, Kirill and Parton, Robert G. (2014). Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. eLIFE, 2014 (3) e01434, e01434.1-e01434.18. doi: 10.7554/eLife.01434

Characterization of in vivo Dlg1 deletion on T cell development and function

Humphries, Lisa A., Shaffer, Meredith H., Sacirbegovic, Faruk, Tomassian, Tamar, McMahon, Kerrie-Ann, Humbert, Patrick O., Silva, Oscar, Round, June L., Takamiya, Kogo, Huganir, Richard L., Burkhardt, Janis K., Russell, Sarah M. and Miceli, M. Carrie (2012). Characterization of in vivo Dlg1 deletion on T cell development and function. PLoS ONE, 7 (9) e45276, e45276. doi: 10.1371/journal.pone.0045276

SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function

McMahon, Kerrie-Ann, Zajicek, Hubert, Li, Wei-Ping, Peyton, Michael J, Minna, John D, Hernandez, V James, Luby-Phelps, Katherine and Anderson, Richard G. W. (2009). SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. EMBO Journal, 28 (8), 1001-1015. doi: 10.1038/emboj.2009.46

Detergent-free caveolae proteome suggests an interaction with ER and mitochondria

McMahon, Kerrie-Ann, Zhu, Meifang, Kwon, Sung Won, Liu, Pingsheng, Zhao, Yingming and Anderson, Richard G. W. (2006). Detergent-free caveolae proteome suggests an interaction with ER and mitochondria. Proteomics, 6 (1), 143-152. doi: 10.1002/pmic.200500208

Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: A role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity

McMahon, K. A., Wilson, N. J., Marks, D. C., Beecroft, T. L., Whitty, G. A., Hamilton, J. A. and Csar, X. F. (2001). Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: A role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity. Biochemical Journal, 358 (2), 431-436. doi: 10.1042/0264-6021:3580431

Proteomic analysis of macrophage differentiation: p46/52Shc tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation

Csar, Xavier F., Wilson, Nicholas J., McMahon, Kerrie-Ann, Marks, Denese C., Beecroft, Tina L., Ward, Alister C., Whitty, Genevieve A., Kanangasundarum, Varuni and Hamilton, John A. (2001). Proteomic analysis of macrophage differentiation: p46/52Shc tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation. Journal of Biological Chemistry, 276 (28), 26211-26217. doi: 10.1074/jbc.M100213200

Copper/zinc superoxide dismutase is phosphorylated and modulated specifically by granulocyte-colony stimulating factor in myeloid cells

Csar, Xavier F., Wilson, Nicholas J., Strike, Philip, Sparrow, Lindsay, McMahon, Kerrie Ann, Ward, Alister C. and Hamilton, John A. (2001). Copper/zinc superoxide dismutase is phosphorylated and modulated specifically by granulocyte-colony stimulating factor in myeloid cells. Proteomics, 1 (3), 435-443. doi: 10.1002/1615-9861(200103)1:3<435::AID-PROT435>3.0.CO;2-Q

A role for caveolar proteins in regulation of the circadian clock

Fonseka, Sachini, Weger, Benjamin D., Weger, Meltem, Martel, Nick, Hall, Thomas Edward, Varasteh Moradi, Shayli, Gabriel, Christian H., Kramer, Achim, Ferguson, Charles, Fernández-Rojo, Manuel A., Alexandrov, Kirill, Rawashdeh, Oliver, McMahon, Kerrie-Ann, Gachon, Frederic and Parton, Robert G. (2022). A role for caveolar proteins in regulation of the circadian clock.