Journal Article: Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivo
Althobity, Abdullah A., Khan, Nemat, Sandrock, Cheyenne J., Woodruff, Trent M, Cowin, Gary J., Brereton, Ian M. and Kurniawan, Nyoman D. (2023). Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivo. NMR in Biomedicine, 36 (10) e4964. doi: 10.1002/nbm.4964
Journal Article: Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain
Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic and Medicinal Chemistry, 69 116889, 1-10. doi: 10.1016/j.bmc.2022.116889
Journal Article: β-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping
Bouchery, Tiffany, Volpe, Beatrice, Doolan, Rory, Coakley, Gillian, Moyat, Mati, Esser-von Bieren, Julia, Wickramasinghe, Lakshanie C, Hibbs, Margaret L, Sotillo, Javier, Camberis, Mali, Le Gros, Graham, Khan, Nemat, Williams, David and Harris, Nicola L (2022). β-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping. Immunology and Cell Biology, 100 (4), 223-234. doi: 10.1111/imcb.12536
(2023–2026) National Multiple Sclerosis Society-US
(2022–2023) Multiple Sclerosis Research Australia - Targeted Grant - Neurodegeneration
Eph receptor blockade to prevent and repair endothelial damage in systemic inflammation
(2020–2022) The Children's Hospital Foundation
Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.
Doctor Philosophy
Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.
Doctor Philosophy
(2023) Doctor Philosophy
To study pathobiological mechanisms and develop novel drug treatments for Multiple Sclerosis (MS)
To study pathobiological mechanisms and develop novel drug treatments for sepsis and acute lung injury
Althobity, Abdullah A., Khan, Nemat, Sandrock, Cheyenne J., Woodruff, Trent M, Cowin, Gary J., Brereton, Ian M. and Kurniawan, Nyoman D. (2023). Multi-parametric MR for detection of pathological changes in CNS of mouse model of multiple sclerosis in vivo. NMR in Biomedicine, 36 (10) e4964. doi: 10.1002/nbm.4964
Kong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic and Medicinal Chemistry, 69 116889, 1-10. doi: 10.1016/j.bmc.2022.116889
Bouchery, Tiffany, Volpe, Beatrice, Doolan, Rory, Coakley, Gillian, Moyat, Mati, Esser-von Bieren, Julia, Wickramasinghe, Lakshanie C, Hibbs, Margaret L, Sotillo, Javier, Camberis, Mali, Le Gros, Graham, Khan, Nemat, Williams, David and Harris, Nicola L (2022). β-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping. Immunology and Cell Biology, 100 (4), 223-234. doi: 10.1111/imcb.12536
Post-COVID opsoclonus myoclonus syndrome: a case report from Pakistan
Ishaq, Hira, Durrani, Talha, Umar, Zainab, Khan, Nemat, McCombe, Pamela and Ul Haq, Mian Ayaz (2021). Post-COVID opsoclonus myoclonus syndrome: a case report from Pakistan. Frontiers in Neurology, 12 672524, 672524. doi: 10.3389/fneur.2021.672524
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2021). Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods. Clinical and Experimental Pharmacology and Physiology, 48 (1) 1440-1681.13402, 96-106. doi: 10.1111/1440-1681.13402
Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease. Clinical and Experimental Pharmacology and Physiology, 47 (10) 1440-1681.13363, 1740-1750. doi: 10.1111/1440-1681.13363
Park, Thomas S.W., Khan, Nemat, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2019). J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain. Biomedicine and Pharmacotherapy, 117 109056, 109056. doi: 10.1016/j.biopha.2019.109056
Shenoy, Priyank A., Kuo, Andy, Khan, Nemat, Gorham, Louise, Nicholson, Janet, Corradini, Laura, Vetter, Irina and Smith, Maree T. (2018). The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain. Frontiers in Pharmacology, 9 (MAY) 495, 495. doi: 10.3389/fphar.2018.00495
Khan, Nemat, Muralidharan, Arjun and Smith, Maree T. (2017). Attenuation of the Infiltration of Angiotensin II Expressing CD3(+) T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia - A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT(2)) Receptor Antagonist. Frontiers in Molecular Neuroscience, 10 389, 389. doi: 10.3389/fnmol.2017.00389
Khan, Nemat, Kuo, Andy, Brockman, David A, Cooper, Matthew A and Smith, Maree T (2017). Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain. Inflammopharmacology, 26 (1), 77-86. doi: 10.1007/s10787-017-0401-9
Neurotrophins and neuropathic pain: role in pathobiology
Khan, Nemat and Smith, Maree T. (2015). Neurotrophins and neuropathic pain: role in pathobiology. Molecules, 20 (6), 10657-10688. doi: 10.3390/molecules200610657
Khan, Nemat, Gordon, Richard, Woodruff, Trent M. and Smith, Maree T. (2015). Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signalling in the dorsal horn of the spinal cord. Pharmacology Research and Perspectives, 3 (3) e00137, 1-16. doi: 10.1002/prp2.137
Khan, Nemat, Woodruff, Trent M. and Smith, Maree T. (2014). Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. Pharmacology Biochemistry and Behavior, 126, 13-27. doi: 10.1016/j.pbb.2014.09.003
Khan, Nemat and Smith, Maree T. (2013). Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology, 22 (1), 1-22. doi: 10.1007/s10787-013-0195-3
Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.
Qayum, Mughal, Nisar, Muhammad, Shah, Muhammad Raza, Adhikari, Achyut, Kaleem, Waqar Ahmad, Khan, Inamullah, Khan, Nematullah, Gul, Farah, Khan, Ihsan Ali, Zia-ul-Haq, M. and Khan, Abad (2012). Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.. Phytotherapy Research, 26 (4), 552-556. doi: 10.1002/ptr.3574
Rizvi, Syed Umar Farooq, Siddiqui, Hamid Latif, Nisar, Muhammad, Khan, Nematullah and Khan, Inamullah (2012). Discovery and molecular docking of quinolyl-thienyl chalcones as anti-angiogenic agents targeting VEGFR-2 tyrosine kinase. Bioorganic and Medicinal Chemistry Letters, 22 (2), 942-944. doi: 10.1016/j.bmcl.2011.12.017
Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc.
Khan, Inamullah, Nisar, Muhammad, Shah, Muhammad Raza, Shah, Hamidullah, Gilani, Syed Naeemuddin, Gul, Farah, Abdullah, Syed Muhammad, Ismail, Mohammad, Khan, Nematullah, Kaleem, Waqar Ahmad, Qayum, Mughal, Khan, Haroon, Obaidullah, Samiullah and Ullah, Majeed (2011). Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc.. Fitoterapia, 82 (7), 1003-1007. doi: 10.1016/j.fitote.2011.06.003
Molecular simulations probing Kushecarpin A as a new lipoxygenase inhibitor
Nisar, Muhammad, Kaleem, Wagar Ahmad, Khan, Inamullah, Adhikari, Achyut, Khan, Nematullah, Shah, Muhammad Raza, Khan, Ihsan Ali, Qayum, Mughal, Samiullah, Ismail, Muhammad and Aman, Akhter (2011). Molecular simulations probing Kushecarpin A as a new lipoxygenase inhibitor. Fitoterapia, 82 (7), 1008-1011. doi: 10.1016/j.fitote.2011.06.002
Antimicrobial activities of Conyzolide and Conyzoflavone from Conyza canadensis
Shakirullah, Mohammad, Ahmad, Hanif, Shah, Muhammad Raza, Ahmad, Imtiaz, Ishaq, Muhammad, Khan, Nematullah, Badshah, Amir and Khan, Inamullah (2011). Antimicrobial activities of Conyzolide and Conyzoflavone from Conyza canadensis. Journal of Enzyme Inhibition and Medicinal Chemistry, 26 (4), 468-471. doi: 10.3109/14756366.2010.528413
Khan, Inamullah, Nisar, Muhammad, Khan, Nematullah, Saeed, Muhammad, Nadeem, Said, Fazal-ur-Rehman, Ali, Farooq, Karim, Nasiara, Kaleem, Waqar Ahmad, Qayum, Mughal, Ahmad, Hanif and Khan, Ihsan Ali (2010). Structural insights to investigate Conypododiol as a dual cholinesterase inhibitor from Asparagus adscendens. Fitoterapia, 81 (8), 1020-1025. doi: 10.1016/j.fitote.2010.06.022
Analgesic and anti-inflammatory activities of 11-O-galloylbergenin
Arfan, Mohammad, Amin, Hazrat, Khan, Nematullah, Khan, Inamullah, Saeed, Muhammad, Khan, Muhammad Azim and Fazal-ur-Rehman (2010). Analgesic and anti-inflammatory activities of 11-O-galloylbergenin. Journal of Ethnopharmacology, 131 (2), 502-504. doi: 10.1016/j.jep.2010.06.040
Subhan, Fazal, Khan, Nematullah and Sewell, Robert D. E. (2009). Adulterant profile of illicit street heroin and reduction of its precipitated physical dependence withdrawal syndrome by extracts of st john's wort (hypericum perforatum). Phytotherapy Research, 23 (4), 564-571. doi: 10.1002/ptr.2692
Cellular and molecular insights into multiple sclerosis-induced neuropathic pain
Khan, Nematullah (2015). Cellular and molecular insights into multiple sclerosis-induced neuropathic pain. PhD Thesis, School of Pharmacy, The University of Queensland. doi: 10.14264/uql.2015.387
(2023–2026) National Multiple Sclerosis Society-US
(2022–2023) Multiple Sclerosis Research Australia - Targeted Grant - Neurodegeneration
Eph receptor blockade to prevent and repair endothelial damage in systemic inflammation
(2020–2022) The Children's Hospital Foundation
Neuroprotective role of novel acid-sensing ion channel inhibitor in Multiple sclerosis (MS) disease
(2020–2022) Multiple Sclerosis Research Australia
Role of NLRP3 inflammasome activation in the prognosis of secondary progressive multiple sclerosis
(2019–2020) Metro North Hospital and Health Service
(2017) Ian Potter Foundation
Novel Pain therapeutics discovery: Probing molecular mechanisms
(2016) NHMRC Equipment Grant
Developing novel acid-sensing ion channel inhibitors as neuroprotective leads and diagnostic agents for multiple sclerosis.
Doctor Philosophy — Associate Advisor
Other advisors:
Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.
Doctor Philosophy — Associate Advisor
Other advisors:
Charaterisation of ion channels as pattern recognition receptors for acidosis and potential anti-inflammatory targets.
Doctor Philosophy — Associate Advisor
Other advisors:
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
Insight into the Pathobiology of Breast Cancer Induced Bone Pain in a Rat Model
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
To study pathobiological mechanisms and develop novel drug treatments for Multiple Sclerosis (MS)
To study pathobiological mechanisms and develop novel drug treatments for sepsis and acute lung injury