Dr Fleur Garton

NHMRC ECR Fellow

Institute for Molecular Bioscience
f.garton@imb.uq.edu.au
+61 7 334 66408

Overview

Fleur Garton completed a Bachelor of Applied Science (Sports and Exercise Science) in 2008 at the University of Sydney. Pursing an interest in the molecular basis of skeletal muscle function she completed her honours and PhD at the Institute of Neuroscience and Muscle research at the Children’s Hospital Westmead. Here, she was part of Professor Kathryn North’s team looking at the molecular mechanisms of ACTN3, the “gene for speed,” on muscle adaptation. Fleur remained with the team as post-doctoral researcher and spent two years at the Murdoch Childrens Research Institute, Melbourne. She was responsible for modelling the effect of gene dosage using rAAV vectors while helping to build the Athlome Project Consortium to understand the mechanistic extremes of performance and health. In 2016, Fleur was awarded a Bill Gole MND Postdoctoral fellowship from MNDRIA to join the team at CNSG. Focussed on the mechanisms of motor neurone disease, the project will pursue rapid improvements in diagnosis and treatments through the use of novel genomics analyses and patient disease models.

Research Interests

  • Motor Neurone Disease
  • Genetic variants influencing performance
  • Neuromuscular Disease

Qualifications

  • Doctor of Philosophy, The University of Sydney

Publications

  • Garton, Fleur C., Houweling, Peter J., Vukcevic, Damjan, Meehan, Lyra R., Lee, Fiona X.Z., Lek, Monkol, Roeszler, Kelly N., Hogarth, Marshall W., Tiong, Chrystal F., Zannino, Diana, Yang, Nan, Leslie, Stephen, Gregorevic, Paul, Head, Stewart I., Seto, Jane T. and North, Kathryn N. (2018) The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance. American Journal of Human Genetics, 102 5: 845-857. doi:10.1016/j.ajhg.2018.03.009

  • Henderson, Robert D., Garton, Fleur C., Kiernan, Matthew C., Turner, Martin R. and Eisen, Andrew (2018) Human cerebral evolution and the clinical syndrome of amyotrophic lateral sclerosis. JNNP Online, jnnp-2017. doi:10.1136/jnnp-2017-317245

  • Papadimitriou, Ioannis D., Lockey, Sarah J., Voisin, Sarah, Herbert, Adam J., Garton, Fleur, Houweling, Peter J., Cieszczyk, Pawel, Maciejewska-Skrendo, Agnieszka, Sawczuk, Marek, Massidda, Myosotis, Calò, Carla Maria, Astratenkova, Irina V., Kouvatsi, Anastasia, Druzhevskaya, Anastasiya M., Jacques, Macsue, Ahmetov, Ildus I., Stebbings, Georgina K., Heffernan, Shane, Day, Stephen H., Erskine, Robert, Pedlar, Charles, Kipps, Courtney, North, Kathryn N., Williams, Alun G. and Eynon, Nir (2018) No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes. BMC Genomics, 19 1: 1-9. doi:10.1186/s12864-017-4412-0

View all Publications

Publications

Journal Article

  • Garton, Fleur C., Houweling, Peter J., Vukcevic, Damjan, Meehan, Lyra R., Lee, Fiona X.Z., Lek, Monkol, Roeszler, Kelly N., Hogarth, Marshall W., Tiong, Chrystal F., Zannino, Diana, Yang, Nan, Leslie, Stephen, Gregorevic, Paul, Head, Stewart I., Seto, Jane T. and North, Kathryn N. (2018) The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance. American Journal of Human Genetics, 102 5: 845-857. doi:10.1016/j.ajhg.2018.03.009

  • Henderson, Robert D., Garton, Fleur C., Kiernan, Matthew C., Turner, Martin R. and Eisen, Andrew (2018) Human cerebral evolution and the clinical syndrome of amyotrophic lateral sclerosis. JNNP Online, jnnp-2017. doi:10.1136/jnnp-2017-317245

  • Papadimitriou, Ioannis D., Lockey, Sarah J., Voisin, Sarah, Herbert, Adam J., Garton, Fleur, Houweling, Peter J., Cieszczyk, Pawel, Maciejewska-Skrendo, Agnieszka, Sawczuk, Marek, Massidda, Myosotis, Calò, Carla Maria, Astratenkova, Irina V., Kouvatsi, Anastasia, Druzhevskaya, Anastasiya M., Jacques, Macsue, Ahmetov, Ildus I., Stebbings, Georgina K., Heffernan, Shane, Day, Stephen H., Erskine, Robert, Pedlar, Charles, Kipps, Courtney, North, Kathryn N., Williams, Alun G. and Eynon, Nir (2018) No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes. BMC Genomics, 19 1: 1-9. doi:10.1186/s12864-017-4412-0

  • Gratten, Jacob, Zhao, Qiongyi, Benyamin, Beben, Garton, Fleur, He, Ji, Leo, Paul J., Mangelsdorf, Marie, Anderson, Lisa, Zhang, Zong-Hong, Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Edson, Janette, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jin, Zi-Bing, Li, Zhongshan, Lin, Yong, Liu, Xiaolu, Marshall, Mhairi, Mowry, Bryan J., Ran, Shu, Reutens, David C., Song, Sharon, Tan, Li-Jun, Tang, Lu, Wallace, Robyn H., Wheeler, Lawrie, Wu, Jinyu, Yang, Jian, Xu, Huji, Visscher, Peter M., Bartlett, Perry F., Brown, Matthew A., Wray, Naomi R. and Fan, Dongsheng (2017) Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese. Genome Medicine, 9 97: 97. doi:10.1186/s13073-017-0487-0

  • Benyamin, Beben, He, Ji, Zhao, Qiongyi, Gratten, Jacob, Garton, Fleur, Leo, Paul J., Liu, Zhijun, Mangelsdorf, Marie, Al-Chalabi, Ammar, Anderson, Lisa, Butler, Timothy J., Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Devine, Matthew, Edson, Janette, Fifita, Jennifer A., Furlong, Sarah, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jeffree, Rosalind L., Jin, Zi-Bing, Li, Zhongshan, Li, Ting, Li, Mengmeng, Lin, Yong, Liu, Xiaolu, Marshall, Mhairi, McCann, Emily P., Mowry, Bryan J., Ngo, Shyuan T., Pamphlett, Roger, Ran, Shu, Reutens, David C., Rowe, Dominic B., Sachdev, Perminder, Shah, Sonia, Song, Sharon, Tan, Li-Jun, Tang, Lu, van den Berg, Leonard H., van Rheenen, Wouter, Veldink, Jan H., Wallace, Robyn H., Wheeler, Lawrie, Williams, Kelly L., Wu, Jinyu, Wu, Xin, Yang, Jian, Yue, Weihua, Zhang, Zong-Hong, Zhang, Dai, Noakes, Peter G., Blair, Ian P., Henderson, Robert D., McCombe, Pamela A., Visscher, Peter M., Xu, Huji, Bartlett, Perry F., Brown, Matthew A., Wray, Naomi R. and Fan, Dongsheng (2017) Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature Communications, 8 1: 611. doi:10.1038/s41467-017-00471-1

  • Willems, Sara M., Wright, Daniel J., Day, Felix R., Trajanoska, Katerina, Joshi, Peter K., Morris, John A., Matteini, Amy M., Garton, Fleur C., Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J., Lotta, Luca A., Miyamoto-Mikami, Eri, Rivas, Manuel A., White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R., Austin, Krista, Benyamin, Beben, Brage, Soren, Cheng, Yu-Ching, Cieszczyk, Pawel, Derave, Wim, Eriksson, Karl-Fredrik, Eynon, Nir, Linneberg, Allan, Lucia, Alejandro, Massidda, Myosotis, Mitchell, Braxton D., Miyachi, Motohiko, Murakami, Haruka, Padmanabhan, Sandosh, Pandey, Ashutosh, Papadimitriou, Loannis, Rajpal, Deepak K., Sale, Craig, Schnurr, Theresia M., Sessa, Francesco, Shrine, Nick, Tobin, Martin D., Varley, Ian, Wain, Louise V., Wray, Naomi R., Lindgren, Cecilia M., MacArthur, Daniel G., Waterworth, Dawn M., McCarthy, Mark I., Pedersen, Oluf, Khaw, Kay-Tee, Kie, Douglas P., Pitsiladis, Yannis, Fuku, Noriyuki, Franks, Paul W., North, Kathryn N., van Duijn, Cornelia M., Mather, Karen A., Hansen, Torben, Hansson, Ola, Spector, Tim, Murabito, Joanne M., Richards, J. Brent, Rivadeneira, Fernando, Langenberg, Claudia, Perry, John R. B., Wareham, Nick J., Scott, Robert A., GEFOS Any-Type of Fracture Consortium, Oei, Ling, Zheng, Hou-Feng, Forgetta, Vincenzo, Leong, Aaron, Ahmad, Omar S., Laurin, Charles, Mokry, Lauren E., Ross, Stephanie, Elks, Cathy E., Bowden, Jack, Warrington, Nicole M., Murray, Anna, Ruth, Katherine S., Tsilidis, Konstantinos K., Medina-Gomez, Carolina, Estrada, Karol, Bis, Joshua C., Chasman, Daniel I., Demissie, Serkalem, Enneman, Anke W., Hsu, Yi-Hsiang, Ingvarsson, Thorvaldur, Kaehoenen, Mika, Kammerer, Candace, Lacroix, Andrea Z., Li, Guo, Liu, Ching-Ti, Liu, Yongmei, Lorentzon, Mattias, Maegi, Reedik, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Nielson, Carrie M., Sham, Pack Chung, Siggeirsdotir, Kristin, Sigurdsson, Gunnar, Stefansson, Kari, Trompet, Stella, Thorleifsson, Gudmar, Vandenput, Liesbeth, van der Velde, Nathalie, Viikari, Jorma, Xiao, Su-Mei, Zhao, Jing Hua, Evans, Daniel S, Cummings, Steven R., Cauley, Jane, Duncan, Emma L., de Groot, Lisette C. P. G. M., Esko, Tonu, Gudnason, Vilmundar, Harris, Tamara B., Jackson, Rebecca D., Jukema, J. Wouter, Ikram, Arfan M. A., Karasik, David, Kaptoge, Stephen, Kung, Annie Wai Chee, Lehtimaeki, Terho, Lyytikaeinen, Leo-Pekka, Lips, Paul, Luben, Robert, Metspalu, Andres, van Meurs, Joyce B. J., Minster, Ryan L., Orwoll, Erick, Oei, Edwin, Psaty, Bruce M., Raitakari, Olli T., Ralston, Stuart W., Ridker, Paul M., Robbins, John A., Smith, Albert V., Styrkarsdottir, Unnur, Tranah, Gregory J., Thorstensdottir, Unnur, Uitterlinden, Andre G., Zmuda, Joseph, Zillikens, M. Carola, Ntzani, Evangelia E., Evangelou, Evangelos, Ioannidis, John P. A., Evans, David M. and Ohlsson, Claes (2017) Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness. Nature Communications, 8 16015. doi:10.1038/ncomms16015

  • Garton, Fleur C., Benyamin, Beben, Zhao, Qiongyi, Liu, Zhijun, Gratten, Jacob, Henders, Anjali K., Zhang, Zong-Hong, Edson, Janette, Furlong, Sarah, Morgan, Sarah, Heggie, Susan, Thorpe, Kathryn, Pfluger, Casey, Mather, Karen A., Sachdev, Perminder S., McRae, Allan F., Robinson, Matthew R., Shah, Sonia, Visscher, Peter M., Mangelsdorf, Marie, Henderson, Robert D., Wray, Naomi R. and McCombe, Pamela A. (2017) Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort. Molecular Genetics and Genomic Medicine, 5 4: 418-428. doi:10.1002/mgg3.302

  • Hogarth, Marshall W., Garton, Fleur C., Houweling, Peter J., Tukiainen, Taru, Lek, Monkol, Macarthur, Daniel G., Seto, Jane T., Quinlan, Kate G.R., Yang, Nan, Head, Stewart I. and North, Kathryn N. (2016) Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion. Human Molecular Genetics, 25 5: 866-877. doi:10.1093/hmg/ddv613

  • Pitsiladis, Yannis P., Tanaka, Masashi, Eynon, Nir, Bouchard, Claude, North, Kathryn N., Williams, Alun G., Collins, Malcolm, Moran, Colin N., Britton, Steven L., Fuku, Noriyuki, Ashley, Euan A., Klissouras, Vassilis, Lucia, Alejandro, Ahmetov, Ildus I., De Geus, Eco, Alsayrafi, Mohammed, Webborn, Nick, Wang, Guan, Bishop, David J., Papadimitriou, Ioannis, Yan, Xu, Tirosh, Oren, Kuang, Jujiao, Rankinen, Tuomo, Sarzinsky, Mark, Mikael Mattsson, C., Wheeler, Matthew, Waggott, Daryl, Byrne, Nuala M., Artioli, Guilherme G., September, Alison, Posthumus, Michael, Van der Merwe, Willem, Cieszczyk, Pawel, Leonska-Duniec, Agata, Ficek, Krzysztof, Maciejewska-Karlowska, Agnieszka, Sawczuk, Marek, Stepien-Slodkowska, Marta, Feller, Julian, Dijkstra, Paul, Chmutov, Aleksandr M., Dyatlov, Dmitry A., Orekhov, Evgeniy F., Pushkareva, Yuliya E., Shvedkaya, Irina A., Massidda, Myosotis, Calò, Carla M., Day, Stephen H., Stebbings, Georgina K., Erskine, Robert M., Montgomery, Hugh E., Garton, Fleur C., Houweling, Peter, Derave, Wim, Baguet, Audrey, Muniesa, Carlos A., Sessa, Francesco, Petito, Annamarie, Sale, Craig, Hughes, David C., Varley, Ian, Boomsma, Dorret, Bartels, Meike, Davies, Gareth E., Ginevičienė, Valentina, Jakaitienė, Audronė, Kučinskas, Vaidutis, Tubelis, Linas, Utkus, Algirdas, Milašius, Kazys, Venckunas, Tomas, Skurvydas, Albertas, Stasiulis, Arvydas, Malkova, Dalia, Wilson, Richard, Koch, Lauren G., Zempo, Hirofumi, Naito, Hisashi, Kikuchi, Naoki, Miyamoto-Mikami, Eri, Murakami, Haruka, Miyachi, Motohiko, Takahashi, Hideyuki, Ohiwa, Nao, Kawahara, Takashi, Tsuchie, Hiroyasu, Tobina, Takuro, Ichinoseki-Sekine, Noriko, Tanaka, Hiroaki, Kaneoka, Koji, Nakazato, Koichi, Egorova, Emiliya S., Gabdrakhmanova, Leysan J., Arkhipova, Alina A., Borisova, Alyona V., Gabbasov, Rashid T., Stepanova, Albina A., Kashapov, Ravil I., Rogozkin, Victor A., Astratenkova, Irina V., Druzhevskaya, Anastasiya M., Fedotovskaya, Olga N., Golberg, Natalya D., Hakimullina, Albina M., Kostryukova, Elena S., Alexeev, Dmitry G., Generozov, Edward V., Ischenko, Dmitry S., Kulemin, Nickolay A., Larin, Andrey K., Ospanova, Elena A., Pavlenko, Alexander V., Govorun, Vadim M., Gilep, Andrei A., Gilep, Irina L., Haidukevich, Irina V., Rybina, Irina L., Drozdovska, Svitlana B., Docenko, Victor E., Ilyin, Vladimir N., Lekontsev, Eugeniy, Akimov, Egor B., El-Rayess, Mohamed, Georgakopoulos, Costas, Botre, Francesco, Suhre, Karsten, Hubank, Mike, Wolfarth, Bernd, Greeves, Julie P., Stellingwerff, Trent, Ranson, Craig, Fraser, William D., Grealy, Rebecca, Griffiths, Lyn, Scott, Robert and Pushkarev, Vladimir P. (2016) Athlome project consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance. Physiological Genomics, 48 3: 183-190. doi:10.1152/physiolgenomics.00105.2015

  • Garton, Fleur C., North, Kathryn N., Koch, Lauren G., Britton, Steven L., Nogales-Gadea, Gisela and Lucia, Alejandro (2016) Rodent models for resolving extremes of exercise and health. Physiological Genomics, 48 2: 82-92. doi:10.1152/physiolgenomics.00077.2015

  • Rankinen, Tuomo, Fuku, Noriyuki, Wolfarth, Bernd, Wang, Guan, Sarzynski, Mark A., Alexeev, Dmitry G., Ahmetov, Ildus I., Boulay, Marcel R., Cieszczyk, Pawel, Eynon, Nir, Filipenko, Maxim L., Garton, Fleur C., Generozov, Edward V., Govorun, Vadim M., Houweling, Peter J., Kawahara, Takashi, Kostryukova, Elena S., Kulemin, Nickolay A., Larin, Andrey K., Maciejewska-Karlowska, Agnieszka, Miyachi, Motohiko, Muniesa, Carlos A., Murakami, Haruka, Ospanova, Elena A., Padmanabhan, Sandosh, Pavlenko, Alexander V., Pyankova, Olga N., Santiago, Catalina, Sawczuk, Marek, Scott, Robert A., Uyba, Vladimir V., Yvert, Thomas, Perusse, Louis, Ghosh, Sujoy, Rauramaa, Rainer, North, Kathryn N., Lucia, Alejandro, Pitsiladis, Yannis and Bouchard, Claude (2016) No evidence of a common DNA variant profile specific to world class endurance athletes. PLoS ONE, 11 1: e0147330. doi:10.1371/journal.pone.0147330

  • Sullivan, Kate, El-hoss, Jad, Quinlan, Kate G.R., Deo, Nikita, Garton, Fleur, Seto, Jane T.C., Gdalevitch, Marie, Turner, Nigel, Cooney, Gregory J., Kolanczyk, Mateusz, North, Kathryn N., Little, David G. and Schindeler, Aaron (2014) NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23 5: 1250-1259. doi:10.1093/hmg/ddt515

  • Seto, Jane T., Lek, Monkol, Quinlan, Kate G.R., Houweling, Peter J., Zheng, Xi F., Garton, Fleur, MacArthur, Daniel G., Raftery, Joanna M., Garvey, Sean M., Hauser, Michael A., Yang, Nan, Head, Stewart I. and North, Kathryn N. (2011) Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. Human Molecular Genetics, 20 15: 2914-2927. doi:10.1093/hmg/ddr196

Grants (Administered at UQ)