The University of Queensland

A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling)

Craik, David J., Kaas, Quentin and Wang, Conan K. (2017). A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling). In Eric Marsault and Mark L Peterson (Ed.), Practical medicinal chemistry with macrocycles: Design, synthesis, and case studies (pp. 25-57) Hoboken, New Jersey, United States: John Wiley & Sons. doi:10.1002/9781119092599.ch2

Cyclotide isolation and characterization

Craik, David J., Henriques, Sonia Troeira, Mylne, Joshua S. and Wang, Conan K. (2012). Cyclotide isolation and characterization. In David A. Hopwood (Ed.), Natural product biosynthesis by microorganisms and plants, part B (pp. 37-62) Burlington, USA: Elsevier. doi:10.1016/B978-0-12-394291-3.00024-1

Membrane binding of cyclotides

Wang, Conan K., Huang, Yen-Hua, Greenwood, Kathryn and Craik, David J. (2010). Membrane binding of cyclotides. In Miguel A.R.B. Castanho (Ed.), Membrane-active peptides: Methods and results on structure and function (pp. 597-672) La Jolla, CA, U.S.A.: International University Line.

Calcium-mediated allostery of the EGF fold

Wang, Conan K., Ghani, Hafiza Abdul, Bundock, Anna, Weidmann, Joachim, Harvey, Peta J., Edwards, Ingrid A., Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2018) Calcium-mediated allostery of the EGF fold. ACS Chemical Biology, 13 6: 1659-1667. doi:10.1021/acschembio.8b00291

Designing macrocyclic disulfide-rich peptides for biotechnological applications

Wang, Conan K. and Craik, David J. (2018) Designing macrocyclic disulfide-rich peptides for biotechnological applications. Nature Chemical Biology, 14 5: 417-427. doi:10.1038/s41589-018-0039-y

Conformational Flexibility Is a Determinant of Permeability for Cyclosporin

Wang, Conan K., Swedberg, Joakim E., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2018) Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The Journal of Physical Chemistry. B, 122 8: 2261-2276. doi:10.1021/acs.jpcb.7b12419

Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake

Ojeda, Paola G. , Henriques, Sonia Troeira, Pan, Yijun, Nicolazzo, Joseph A., Craik, David J. and Wang, Conan K. (2017) Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake. Biopolymers, 108 5: e23025. doi:10.1002/bip.23025

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J. and Craik, David J. (2017) Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 41: 17101-17112. doi:10.1074/jbc.M117.808386

Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold

Swedberg, Joakim E., Li, Choi Yi, De Veer, Simon J., Wang, Conan K. and Craik, David J. (2017) Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold. Journal of Medicinal Chemistry, 60 2: 658-667. doi:10.1021/acs.jmedchem.6b01509

Cyclic peptide oral bioavailability: lessons from the past

Wang, Conan K. and Craik, David J. (2016) Cyclic peptide oral bioavailability: lessons from the past. Biopolymers, 106 6: 901-909. doi:10.1002/bip.22878

Forward for ICCP2015 issue of biopolymers peptide science

Craik, David J. and Wang, Conan K. (2016) Forward for ICCP2015 issue of biopolymers peptide science. Biopolymers, 106 6: 772-773. doi:10.1002/bip.22989

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016) Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 10: 2202-2212. doi:10.1002/bit.25993

Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold

Wang, Conan K., Stalmans, Sofie, De Spiegeleer, Bart and Craik, David J. (2016) Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold. Journal of Peptide Science, 22 5: 305-310. doi:10.1002/psc.2862

Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties

Wang, Conan K., King, Gordon J., Conibear, Anne C., Ramos, Mariana C., Chaousis, Stephanie, Henriques, Sonia Troeira and Craik, David J. (2016) Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. Journal of American Chemical Society, 138 17: 5706-5713. doi:10.1021/jacs.6b02575

Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold

Wang, Conan K., Northfield, Susan E., Huang, Yen-Hua, Ramos, Mariana C. and Craik, David J. (2016) Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry, 109 342-349. doi:10.1016/j.ejmech.2016.01.006

Chlorotoxin: structure, activity, and potential uses in cancer therapy

Ojeda, Paola G., Wang, Conan K. and Craik, David J. (2016) Chlorotoxin: structure, activity, and potential uses in cancer therapy. Biopolymers - Peptide Science, 106 1: 25-36. doi:10.1002/bip.22748

Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer

D'Souza, Charlotte, Henriques, Sonia Troeira, Wang, Conana K., Cheneval, Olivier, Chan, Lai Yue, Bokil, Nilesh J., Sweet, Matthew J. and Craik, David J. (2016) Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer. Biochemistry, 55 2: 396-405. doi:10.1021/acs.biochem.5b00529

Effects of Cyclization on Peptide Backbone Dynamics

Wang, Conan K., Swedberg, Joakim E., Northfield, Susan E. and Craik, David J. (2015) Effects of Cyclization on Peptide Backbone Dynamics. Journal of Physical Chemistry B, 119 52: 15821-15830. doi:10.1021/acs.jpcb.5b11085

Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae

Ravipati, Anjaneya S., Henriques, Sónia Troeira, Poth, Aaron G., Kaas, Quentin, Wang, Conan K., Colgrave, Michelle L. and Craik, David J. (2015) Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae. ACS Chemical Biology, 10 11: 2491-2500. doi:10.1021/acschembio.5b00454

Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library

de Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015) Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 20: 8257-8268. doi:10.1021/acs.jmedchem.5b01148

Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold

Huang, Yen-Hua, Henriques, Sonia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin and Craik, David J. (2015) Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports, 5 1-15. doi:10.1038/srep12974

Exploring experimental and computational markers of cyclic peptides: charting islands of permeability

Wang, Conan K., Northfield, Susan Ellen, Swedberg, Joakim E., Colless, Barbara, Chaousis, Stephanie, Price, David A., Liras, Spiros and Craik, David J. (2015) Exploring experimental and computational markers of cyclic peptides: charting islands of permeability. European Journal of Medicinal Chemistry, 97 202-213. doi:10.1016/j.ejmech.2015.04.049

An integrated Java tool for generating amino acid sequence alignments with mapped secondary structure elements

Wang, Conan K. and Hofmann, Andreas (2015) An integrated Java tool for generating amino acid sequence alignments with mapped secondary structure elements. 3 Biotech, 5 1: 87-92. doi:10.1007/s13205-014-0222-0

Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients

Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014) Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 49: 17504-17509. doi:10.1073/pnas.1417611111

Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis

Conibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014) Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 49: 14257-14266. doi:10.1021/jp507754c

Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1

Taylor, Carol M., Northfield, Susan E., Wang, Conan K. and Craik, David J. (2014) Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1. Tetrahedron, 70 42: 7669-7674. doi:10.1016/j.tet.2014.06.058

Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds

Wang, Conan K., King, Gordon J., Northfield, Susan E., Ojeda, Paola G. and Craik, David J. (2014) Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angewandte Chemie - International Edition, 53 42: 11236-11241. doi:10.1002/anie.201406563

Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins

Rebaud, Samuel, Wang, Conan K., Sarkis, Joe, Mason, Lyndel, Simon, Anne, Blum, Loic J., Hofmann, Andreas and Girard-Egrot, Agnes P. (2014) Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins. Biochimica et Biophysica Acta - Biomembranes, 1838 10: 2698-2707. doi:10.1016/j.bbamem.2014.06.021

The role of disulfide bonds in structure and activity of chlorotoxin

Ojeda, Paola G., Chan, Lai Y., Poth, Aaron G., Wang, Conan K. and Craik, David J. (2014) The role of disulfide bonds in structure and activity of chlorotoxin. Future Medicinal Chemistry, 6 15: 1617-1628. doi:10.4155/FMC.14.93

Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR

Wang, Conan K., Northfield, Susan E., Swedberg, Joakim E., Harvey, Peta J., Mathiowetz, Alan M., Price, David A, Liras, Spiros and Craik, David J. (2014) Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. Journal of Physical Chemistry B, 118 38: 11129-11136. doi:10.1021/jp506678f

Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting

Henriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Steph, Wang, Conan and Craik, David J. (2014) Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem, 15 13: 1956-1965. doi:10.1002/cbic.201402144

Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1

D'Souza, Charlotte, Troeira Henriques, Sonia, Wang, Conan K. and Craik, David J. (2014) Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1. European Journal of Medicinal Chemistry, 88 10-18. doi:10.1016/j.ejmech.2014.06.047

Comparison of VILIP-1 and VILIP-3 binding to phospholipid monolayers

Rebaud S., Simon A., Wang C.K., Mason L., Blum L., Hofmann A. and Girard-Egrot A. (2014) Comparison of VILIP-1 and VILIP-3 binding to phospholipid monolayers. PLoS ONE, 9 4: e93948.1-e93948.8. doi:10.1371/journal.pone.0093948

Disulfide-rich macrocyclic peptides as templates in drug design

Northfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014) Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 2: 248-257. doi:10.1016/j.ejmech.2014.03.011

The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif

Conibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014) The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 3: 451-459. doi:10.1002/cbic.201300568

Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis

Wang, Conan K., Gruber, Christian W., Cemazar, Masa, Siatskas, Christopher, Tagore, Prascilla, Payne, Natalie, Sun, Guizhi, Wang, Shunhe, Bernard, Claude C. and Craik, David J. (2014) Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chemical Biology, 9 1: 156-163. doi:10.1021/cb400548s

Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions

Wang, Conan K., Wacklin, Hanna P. and Craik, David J. (2012) Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions. Journal of Biological Chemistry, 287 52: 43884-43898. doi:10.1074/jbc.M112.421198

Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms

Weeratunga, Saroja K., Osman, Asiah, Hu, Nien-Jen, Wang, Conan K., Mason, Lyndel, Svard, Staffan, Hope, Greg, Jones, Malcolm K. and Hofmann, Andreas (2012) Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms. Journal of Molecular Biology, 423 2: 169-181. doi:10.1016/j.jmb.2012.06.041

Hookworm SCP/TAPS protein structure - A key to understanding host-parasite interactions and developing new interventions

Osman, Asiah, Wang, Conan K., Winter, Anja, Loukas, Alex, Tribolet, Leon, Gasser, Robin B. and Hofmann, Andreas (2012) Hookworm SCP/TAPS protein structure - A key to understanding host-parasite interactions and developing new interventions. Biotechnology Advances, 30 3: 652-657. doi:10.1016/j.biotechadv.2011.11.002

Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration

Xavier, Charles-Peter, Rastetter, Raphael H., Blomacher, Margit, Stumpf, Maria, Himmel, Mirko, Morgan, Reginald O., Fernandez, Maria-Pilar, Wang, Conan, Osman, Asiah, Miyata, Yoshihiko, Gjerset, Ruth A., Eichinger, Ludwig, Hofmann, Andreas, Linder, Stefan, Noegel, Angelika A. and Clemen, Christoph S. (2012) Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration. Scientific Reports, 2 . doi:10.1038/srep00241

SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments

Wang, Conan K., Broder, Ursula, Weeratunga, Saroja K., Gasser, Robin B., Loukas, Alex and Hofmann, Andreas (2012) SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments. Bioinformatics, 28 7: 1026-1027. doi:10.1093/bioinformatics/bts035

DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments

Wang, Conan K., Weeratunga, Saroja K., Pacheco, Chris M. and Hofmann, Andreas (2011) DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments. Bioinformatics, 28 3: 439-440. doi:10.1093/bioinformatics/btr664

Promiscuity of carbonic anhydrase II: Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors

Lopez, Marie, Vu. Hoan, Wang, Conan K., Wolf, Maarten G., Groenhof, Gerrit, Innocentis, Alessio, Supuran, Claudiu T. and Poulsen, Sally-Ann (2011) Promiscuity of carbonic anhydrase II: Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors. Journal of The American Chemical Society, 133 45: 18452-18462. doi:10.1021/ja207855c

Divalent cations and Redox conditions regulate the molecular structure and function of visinin-like protein-1

Wang, Conan K., Simon, Anne, Jessen, Christian M., Oliveira, Cristiano L. P., Mack, Lynsey, Braunewell, Karl-Heinz, Ames, James B., Pedersen, Jan Skov and Hofmann, Andreas (2011) Divalent cations and Redox conditions regulate the molecular structure and function of visinin-like protein-1. PLoS One, 6 11: e26793.1-e26793.10. doi:10.1371/journal.pone.0026793

Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm

Willis, Charlene, Wang, Conan K., Osman, Asiah, Simon, Anne, Pickering, Darren, Mulvenna, Jason, Riboldi-Tunicliffe, Alan, Jones, Malcolm K., Loukas, Alex and Hofmann, Andreas (2011) Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm. PLoS One, 6 10: e25369.1-e25369.10. doi:10.1371/journal.pone.0025369

Atypical (RIO) protein kinases from Haemonchus contortus-promise as new targets for nematocidal drugs

Campbell, Bronwyn E., Boag, Peter R., Hofmann, Andreas, Cantacessi, Cinzia, Wang, Conan K., Taylor, Paul, Hu, Min, Sindhu, Zia-ud-Din, Loukas, Alex, Sternberg, Paul W. and Gasser, Robin B. (2011) Atypical (RIO) protein kinases from Haemonchus contortus-promise as new targets for nematocidal drugs. Biotechnology Advances, 29 3: 338-350. doi:10.1016/j.biotechadv.2011.01.006

The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant

Wang, Conan K. L., Clark, Richard J., Harvey, Peta J., Rosengren, K. Johan, Cemazar, Masa and Craik, David J. (2011) The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry, 50 19: 4077-4086. doi:10.1021/bi2004153

Isolation and characterization of Bioactive Cyclotides from Viola labrilorica

Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010) Isolation and characterization of Bioactive Cyclotides from Viola labrilorica. Helvetica Chimica Acta, 93 11: 2287-2295. doi:10.1002/hlca.201000115

Merging structural biology with chemical biology: Structural Chemistry at Eskitis

Hofmann, Andreas, Wang, Con, Osman, Asiah and Camp, David (2010) Merging structural biology with chemical biology: Structural Chemistry at Eskitis. Structural Chemistry, 21 5: 1117-1129. doi:10.1007/s11224-010-9654-2

Extensions of PDZ domains as important structural and functional elements

Wang, Conan K., Pan, Lifeng, Chen, Jia and Zhang, Mingjie (2010) Extensions of PDZ domains as important structural and functional elements. Protein & Cell, 1 8: 737-751. doi:10.1007/s13238-010-0099-6

Isolation and characterization of cytotoxic cyclotides from Viola tricolor

Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010) Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 31 8: 1434-1440. doi:10.1016/j.peptides.2010.05.004

Cyclotides are a component of the innate defense of Oldenlandia affinis

Mylne, Joshua S, Wang, Conan K, van der Weerden, Nicole L and Craik, David J (2010) Cyclotides are a component of the innate defense of Oldenlandia affinis. Biopolymers, 94 5: 635-646. doi:10.1002/bip.21419

Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes

Wang, C. K., Colgrave, M. L., Ireland, D. C., Kaas, Q and Craik, D. J. (2009) Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes. Biophysical Journal, 97 5: 1471-1481. doi:10.1016/j.bpj.2009.06.032

Isolation and characterization of peptides from momordica cochinchinensis seeds

Chan, L. Y., Wang, C. K., Major, J. M., Greenwood, K. P., Lewis, R. J., Craik, D. J. and Daly, N. L. (2009) Isolation and characterization of peptides from momordica cochinchinensis seeds. JOURNAL OF NATURAL PRODUCTS, 72 8: 1453-1458. doi:10.1021/np900174n

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T, Hajdu, J, Bohlin, L, Claeson, P, Goransson, U, Rosengren, K. J., Tang, J, Tan, N. H. and Craik, D. J. (2009) Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 284 16: 10672-10683. doi:10.1074/jbc.M900021200

NMRDyn: a program for NMR relaxation studies of protein association

Wang, Conan K., Schirra, Horst Joachim and Craik, David J. (2008) NMRDyn: a program for NMR relaxation studies of protein association. PLoS One, 3 11: e3820-1-e3820-7. doi:10.1371/journal.pone.0003820

CyBase: a database of cyclic protein sequences and structures, with application in protein discovery and engineering

Wang, C. K., Kaas, Q., Chiche, L. and Craik, D. J. (2008) CyBase: a database of cyclic protein sequences and structures, with application in protein discovery and engineering. Nucleic Acids Research, 36 SUPPL. 1: D206-D210. doi:10.1093/nar/gkm953

Distribution and evolution of circular miniproteins in flowering plants

Gruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008) Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 9: 2471-2483. doi:10.1105/tpc.108.062331

The anthelmintic activity of the cyclotides: Natural variants with enhanced activity

Colgrave, Michelle L., Kotze, Andrew C., Ireland, David C., Wang, Conan K. and Craik, David J. (2008) The anthelmintic activity of the cyclotides: Natural variants with enhanced activity. ChemBioChem, 9 12: 1939-1945. doi:10.1002/cbic.200800174

Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity

Simonsen, S. M., Sando, L., Rosengren, K. J., Wang, C. K., Colgrave, M. L., Daly, N. L. and Craik, D. J. (2008) Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. Journal of Biological Chemistry, 283 15: 9805-9813. doi:10.1074/jbc.M709303200

ConoServer, a database for conopeptide sequences and structures

Kaas, Quentin, Westermann, Jan, Halai, Reena, Wang, Conan and Craik, David J. (2008) ConoServer, a database for conopeptide sequences and structures. Bioinformatics, 24 3: 445-446. doi:10.1093/bioinformatics/btm596

Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis

Wang, Conan K. L., Colgrave, Michelle L., Gustafson, Kirk R., Ireland, David C., Goransson, Ulf and Craik, David J. (2008) Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis. Journal of Natural Products, 71 1: 47-52. doi:10.1021/np070393g

Cyclotides as natural anti-HIV agents

Ireland, David C., Wang, Conan K., Wilson, Jennifer A., Gustafson, Kirk R. and Craik, David J. (2008) Cyclotides as natural anti-HIV agents. Biopolymers: Peptide Science, 90 1: 51-60. doi:10.1002/bip.20886

CyBase: a database of cyclic protein sequence and structure

Mulvenna, J. P., Wang, C. and Craik, D. J. (2006) CyBase: a database of cyclic protein sequence and structure. Nucleic Acids Research, 34 Sp. Iss. SI: D192-D194. doi:10.1093/nar/gkj005

Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae

Chen, B., Colgrave, M. L., Wang, C. N. and Craik, D. J. (2006) Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae. Journal of Natural Products, 69 1: 23-28. doi:10.1021/np050317i

The cyclotide family of circular miniproteins: Nature's combinatorial peptide template

Craik, D. J., Cemazar, M., Wang, C. K. L. and Daly, N. L. (2006) The cyclotide family of circular miniproteins: Nature's combinatorial peptide template. Biopolymers, 84 3: 250-266. doi:10.1002/hip.20451

Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis

Wang, C. K., Gruber, C. W., Cernazar, M., Siatskas, C., Tagore, P., Sun, G., Wang, S., Bernard, C. and Craik, D. J. (2013). Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. In: 23rd American Peptide Symposium, Waikoloa, Hawaii, (300-300). 22-27 June 2013 .

Cyclotides are a component of the innate defense of Oldenlandia affinis

Mylne, Joshua S., Wang, Conan K., van der Weerden, Nicole L. and Craik, David J. (2010). Cyclotides are a component of the innate defense of Oldenlandia affinis. In: Proceedings of the 1st International Conference on Circular Proteins. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, (635-645). 18-21 October, 2009. doi:10.1002/bip.21419

Structural and functional studies of cyclotides

Wang, Conan (2008). Structural and functional studies of cyclotides PhD Thesis, Institute for Molecular Bioscience, The University of Queensland.