I have been involved in peptide and protein research since 2004, and am highly experienced in bioinformatics, chemistry, structural characterization, biophysics, and biochemistry. I trained with experts in peptide and protein characterization: an honors project with Professor Garry King at the University of New South Wales, Sydney, Australia (2004), an APA scholarship with Professor David Craik at the University of Queensland Institute for Molecular Bioscience, Brisbane, Australia (2005-2009) and a NHMRC fellowship with Professor Mingjie Zhang at the Hong Kong University of Science and Technology, Hong Kong, China (2009-2011) and A/Professor Andreas Hofmann at Griffith University Eskitis Institute, Brisbane, Australia (2011-2012). I returned to the University of Queensland in 2012 to join an industry partnership funded by an ARC linkage grant. I am currently a Senior Research Officer and responsible for a team of research officers, assistants and postgraduate students.
My research initially was on the development of computational methods for prediction of disease phenotypes from single nucleotide polymorphism data, which then moved to the development of computational (database development and molecular dynamics) and biophysical (ITC and NMR) tools for discovery and characterization of cyclic peptides for my PhD. During my postdoctoral research, I studied proteins involved in neurological function and host-immune defense (using X-ray crystallography), and later moved to the design of peptides to target protein-protein interactions involved in autoimmunity and cholesterol metabolism as well as peptides for oral delivery (using NMR, SPR and permeability assays). This research has led to several high impact publications and productive research collaborations, and the skills acquired from it forms the basis of my ongoing research at UQ.
At UQ, my research involves interdisciplinary methods for design and engineering of peptides. I am interested in developing new tools that enable peptides to be translated into next generation biotechnological agents that have real impact.
Journal Article: Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species
Ramalho, Suelem D., Wang, Conan K., King, Gordon J., Byriel, Karl A., Huang, Yen-Hua, Bolzani, Vanderlan S. and Craik, David J. (2018) Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species. Journal of Natural Products, 81 11: 2436-2445. doi:10.1021/acs.jnatprod.8b00447
Journal Article: Calcium-mediated allostery of the EGF fold
Wang, Conan K., Ghani, Hafiza Abdul, Bundock, Anna, Weidmann, Joachim, Harvey, Peta J., Edwards, Ingrid A., Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2018) Calcium-mediated allostery of the EGF fold. ACS Chemical Biology, 13 6: 1659-1667. doi:10.1021/acschembio.8b00291
Journal Article: Designing macrocyclic disulfide-rich peptides for biotechnological applications
Wang, Conan K. and Craik, David J. (2018) Designing macrocyclic disulfide-rich peptides for biotechnological applications. Nature Chemical Biology, 14 5: 417-427. doi:10.1038/s41589-018-0039-y
Biocontrol of crown-of-thorns starfish using genomics and proteomics
(2018–2021) ARC Linkage Projects
New drug leads for cholesterol
(2016–2018) NHMRC Project Grant
Bioengineering stable peptide inhibitors of amyloidosis
(2014) UQ Early Career Researcher
(2015) Doctor Philosophy
NMR relaxation analysis of pharmaceutically active peptides
Wang, Conan K. (2018). NMR relaxation analysis of pharmaceutically active peptides. In Modern Magnetic Resonance (pp. 1997-2020) Cham, Switzerland: Springer International Publishing. doi:10.1007/978-3-319-28388-3_115
A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling)
Craik, David J., Kaas, Quentin and Wang, Conan K. (2017). A practical guide to structural aspects of macrocycles (NMR, x-ray, and modeling). In Eric Marsault and Mark L Peterson (Ed.), Practical medicinal chemistry with macrocycles: Design, synthesis, and case studies (pp. 25-57) Hoboken, New Jersey, United States: John Wiley & Sons. doi:10.1002/9781119092599.ch2
Cyclotide isolation and characterization
Craik, David J., Henriques, Sonia Troeira, Mylne, Joshua S. and Wang, Conan K. (2012). Cyclotide isolation and characterization. In David A. Hopwood (Ed.), Natural product biosynthesis by microorganisms and plants, part B (pp. 37-62) Burlington, USA: Elsevier. doi:10.1016/B978-0-12-394291-3.00024-1
Membrane binding of cyclotides
Wang, Conan K., Huang, Yen-Hua, Greenwood, Kathryn and Craik, David J. (2010). Membrane binding of cyclotides. In Miguel A.R.B. Castanho (Ed.), Membrane-active peptides: Methods and results on structure and function (pp. 597-672) La Jolla, CA, U.S.A.: International University Line.
Ramalho, Suelem D., Wang, Conan K., King, Gordon J., Byriel, Karl A., Huang, Yen-Hua, Bolzani, Vanderlan S. and Craik, David J. (2018) Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species. Journal of Natural Products, 81 11: 2436-2445. doi:10.1021/acs.jnatprod.8b00447
Calcium-mediated allostery of the EGF fold
Wang, Conan K., Ghani, Hafiza Abdul, Bundock, Anna, Weidmann, Joachim, Harvey, Peta J., Edwards, Ingrid A., Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2018) Calcium-mediated allostery of the EGF fold. ACS Chemical Biology, 13 6: 1659-1667. doi:10.1021/acschembio.8b00291
Designing macrocyclic disulfide-rich peptides for biotechnological applications
Wang, Conan K. and Craik, David J. (2018) Designing macrocyclic disulfide-rich peptides for biotechnological applications. Nature Chemical Biology, 14 5: 417-427. doi:10.1038/s41589-018-0039-y
Conformational Flexibility Is a Determinant of Permeability for Cyclosporin
Wang, Conan K., Swedberg, Joakim E., Harvey, Peta J., Kaas, Quentin and Craik, David J. (2018) Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The Journal of Physical Chemistry. B, 122 8: 2261-2276. doi:10.1021/acs.jpcb.7b12419
Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake
Ojeda, Paola G. , Henriques, Sonia Troeira, Pan, Yijun, Nicolazzo, Joseph A., Craik, David J. and Wang, Conan K. (2017) Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake. Biopolymers, 108 5: e23025. doi:10.1002/bip.23025
Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer
Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J. and Craik, David J. (2017) Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 41: 17101-17112. doi:10.1074/jbc.M117.808386
Swedberg, Joakim E., Li, Choi Yi, De Veer, Simon J., Wang, Conan K. and Craik, David J. (2017) Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold. Journal of Medicinal Chemistry, 60 2: 658-667. doi:10.1021/acs.jmedchem.6b01509
Cyclic peptide oral bioavailability: lessons from the past
Wang, Conan K. and Craik, David J. (2016) Cyclic peptide oral bioavailability: lessons from the past. Biopolymers, 106 6: 901-909. doi:10.1002/bip.22878
Forward for ICCP2015 issue of biopolymers peptide science
Craik, David J. and Wang, Conan K. (2016) Forward for ICCP2015 issue of biopolymers peptide science. Biopolymers, 106 6: 772-773. doi:10.1002/bip.22989
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide
Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016) Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 10: 2202-2212. doi:10.1002/bit.25993
Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold
Wang, Conan K., Stalmans, Sofie, De Spiegeleer, Bart and Craik, David J. (2016) Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold. Journal of Peptide Science, 22 5: 305-310. doi:10.1002/psc.2862
Wang, Conan K., King, Gordon J., Conibear, Anne C., Ramos, Mariana C., Chaousis, Stephanie, Henriques, Sonia Troeira and Craik, David J. (2016) Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. Journal of American Chemical Society, 138 17: 5706-5713. doi:10.1021/jacs.6b02575
Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold
Wang, Conan K., Northfield, Susan E., Huang, Yen-Hua, Ramos, Mariana C. and Craik, David J. (2016) Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry, 109 342-349. doi:10.1016/j.ejmech.2016.01.006
Chlorotoxin: structure, activity, and potential uses in cancer therapy
Ojeda, Paola G., Wang, Conan K. and Craik, David J. (2016) Chlorotoxin: structure, activity, and potential uses in cancer therapy. Biopolymers - Peptide Science, 106 1: 25-36. doi:10.1002/bip.22748
D'Souza, Charlotte, Henriques, Sonia Troeira, Wang, Conana K., Cheneval, Olivier, Chan, Lai Yue, Bokil, Nilesh J., Sweet, Matthew J. and Craik, David J. (2016) Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer. Biochemistry, 55 2: 396-405. doi:10.1021/acs.biochem.5b00529
Effects of Cyclization on Peptide Backbone Dynamics
Wang, Conan K., Swedberg, Joakim E., Northfield, Susan E. and Craik, David J. (2015) Effects of Cyclization on Peptide Backbone Dynamics. Journal of Physical Chemistry B, 119 52: 15821-15830. doi:10.1021/acs.jpcb.5b11085
Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae
Ravipati, Anjaneya S., Henriques, Sónia Troeira, Poth, Aaron G., Kaas, Quentin, Wang, Conan K., Colgrave, Michelle L. and Craik, David J. (2015) Lysine-rich cyclotides: a new subclass of circular knotted proteins from violaceae. ACS Chemical Biology, 10 11: 2491-2500. doi:10.1021/acschembio.5b00454
de Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015) Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 20: 8257-8268. doi:10.1021/acs.jmedchem.5b01148
Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold
Huang, Yen-Hua, Henriques, Sonia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin and Craik, David J. (2015) Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports, 5 1-15. doi:10.1038/srep12974
Wang, Conan K., Northfield, Susan Ellen, Swedberg, Joakim E., Colless, Barbara, Chaousis, Stephanie, Price, David A., Liras, Spiros and Craik, David J. (2015) Exploring experimental and computational markers of cyclic peptides: charting islands of permeability. European Journal of Medicinal Chemistry, 97 202-213. doi:10.1016/j.ejmech.2015.04.049
Wang, Conan K. and Hofmann, Andreas (2015) An integrated Java tool for generating amino acid sequence alignments with mapped secondary structure elements. 3 Biotech, 5 1: 87-92. doi:10.1007/s13205-014-0222-0
Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014) Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 49: 17504-17509. doi:10.1073/pnas.1417611111
Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis
Conibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014) Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 49: 14257-14266. doi:10.1021/jp507754c
Taylor, Carol M., Northfield, Susan E., Wang, Conan K. and Craik, David J. (2014) Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1. Tetrahedron, 70 42: 7669-7674. doi:10.1016/j.tet.2014.06.058
Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds
Wang, Conan K., King, Gordon J., Northfield, Susan E., Ojeda, Paola G. and Craik, David J. (2014) Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angewandte Chemie - International Edition, 53 42: 11236-11241. doi:10.1002/anie.201406563
Rebaud, Samuel, Wang, Conan K., Sarkis, Joe, Mason, Lyndel, Simon, Anne, Blum, Loic J., Hofmann, Andreas and Girard-Egrot, Agnes P. (2014) Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins. Biochimica et Biophysica Acta - Biomembranes, 1838 10: 2698-2707. doi:10.1016/j.bbamem.2014.06.021
The role of disulfide bonds in structure and activity of chlorotoxin
Ojeda, Paola G., Chan, Lai Y., Poth, Aaron G., Wang, Conan K. and Craik, David J. (2014) The role of disulfide bonds in structure and activity of chlorotoxin. Future Medicinal Chemistry, 6 15: 1617-1628. doi:10.4155/FMC.14.93
Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR
Wang, Conan K., Northfield, Susan E., Swedberg, Joakim E., Harvey, Peta J., Mathiowetz, Alan M., Price, David A, Liras, Spiros and Craik, David J. (2014) Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. Journal of Physical Chemistry B, 118 38: 11129-11136. doi:10.1021/jp506678f
Henriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Steph, Wang, Conan and Craik, David J. (2014) Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem, 15 13: 1956-1965. doi:10.1002/cbic.201402144
D'Souza, Charlotte, Troeira Henriques, Sonia, Wang, Conan K. and Craik, David J. (2014) Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1. European Journal of Medicinal Chemistry, 88 10-18. doi:10.1016/j.ejmech.2014.06.047
Comparison of VILIP-1 and VILIP-3 binding to phospholipid monolayers
Rebaud S., Simon A., Wang C.K., Mason L., Blum L., Hofmann A. and Girard-Egrot A. (2014) Comparison of VILIP-1 and VILIP-3 binding to phospholipid monolayers. PLoS ONE, 9 4: e93948.1-e93948.8. doi:10.1371/journal.pone.0093948
Disulfide-rich macrocyclic peptides as templates in drug design
Northfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014) Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 2: 248-257. doi:10.1016/j.ejmech.2014.03.011
Conibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014) The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 3: 451-459. doi:10.1002/cbic.201300568
Wang, Conan K., Gruber, Christian W., Cemazar, Masa, Siatskas, Christopher, Tagore, Prascilla, Payne, Natalie, Sun, Guizhi, Wang, Shunhe, Bernard, Claude C. and Craik, David J. (2014) Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chemical Biology, 9 1: 156-163. doi:10.1021/cb400548s
Wang, Conan K., Wacklin, Hanna P. and Craik, David J. (2012) Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions. Journal of Biological Chemistry, 287 52: 43884-43898. doi:10.1074/jbc.M112.421198
Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms
Weeratunga, Saroja K., Osman, Asiah, Hu, Nien-Jen, Wang, Conan K., Mason, Lyndel, Svard, Staffan, Hope, Greg, Jones, Malcolm K. and Hofmann, Andreas (2012) Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms. Journal of Molecular Biology, 423 2: 169-181. doi:10.1016/j.jmb.2012.06.041
Osman, Asiah, Wang, Conan K., Winter, Anja, Loukas, Alex, Tribolet, Leon, Gasser, Robin B. and Hofmann, Andreas (2012) Hookworm SCP/TAPS protein structure - A key to understanding host-parasite interactions and developing new interventions. Biotechnology Advances, 30 3: 652-657. doi:10.1016/j.biotechadv.2011.11.002
Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration
Xavier, Charles-Peter, Rastetter, Raphael H., Blomacher, Margit, Stumpf, Maria, Himmel, Mirko, Morgan, Reginald O., Fernandez, Maria-Pilar, Wang, Conan, Osman, Asiah, Miyata, Yoshihiko, Gjerset, Ruth A., Eichinger, Ludwig, Hofmann, Andreas, Linder, Stefan, Noegel, Angelika A. and Clemen, Christoph S. (2012) Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration. Scientific Reports, 2 . doi:10.1038/srep00241
SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments
Wang, Conan K., Broder, Ursula, Weeratunga, Saroja K., Gasser, Robin B., Loukas, Alex and Hofmann, Andreas (2012) SBAL: A practical tool to generate and edit structure-based amino acid sequence alignments. Bioinformatics, 28 7: 1026-1027. doi:10.1093/bioinformatics/bts035
DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments
Wang, Conan K., Weeratunga, Saroja K., Pacheco, Chris M. and Hofmann, Andreas (2011) DMAN: a java tool for analysis of multi-well differential scanning fluorimetry experiments. Bioinformatics, 28 3: 439-440. doi:10.1093/bioinformatics/btr664
Lopez, Marie, Vu. Hoan, Wang, Conan K., Wolf, Maarten G., Groenhof, Gerrit, Innocentis, Alessio, Supuran, Claudiu T. and Poulsen, Sally-Ann (2011) Promiscuity of carbonic anhydrase II: Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors. Journal of The American Chemical Society, 133 45: 18452-18462. doi:10.1021/ja207855c
Wang, Conan K., Simon, Anne, Jessen, Christian M., Oliveira, Cristiano L. P., Mack, Lynsey, Braunewell, Karl-Heinz, Ames, James B., Pedersen, Jan Skov and Hofmann, Andreas (2011) Divalent cations and Redox conditions regulate the molecular structure and function of visinin-like protein-1. PLoS One, 6 11: e26793.1-e26793.10. doi:10.1371/journal.pone.0026793
Willis, Charlene, Wang, Conan K., Osman, Asiah, Simon, Anne, Pickering, Darren, Mulvenna, Jason, Riboldi-Tunicliffe, Alan, Jones, Malcolm K., Loukas, Alex and Hofmann, Andreas (2011) Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm. PLoS One, 6 10: e25369.1-e25369.10. doi:10.1371/journal.pone.0025369
Campbell, Bronwyn E., Boag, Peter R., Hofmann, Andreas, Cantacessi, Cinzia, Wang, Conan K., Taylor, Paul, Hu, Min, Sindhu, Zia-ud-Din, Loukas, Alex, Sternberg, Paul W. and Gasser, Robin B. (2011) Atypical (RIO) protein kinases from Haemonchus contortus-promise as new targets for nematocidal drugs. Biotechnology Advances, 29 3: 338-350. doi:10.1016/j.biotechadv.2011.01.006
Wang, Conan K. L., Clark, Richard J., Harvey, Peta J., Rosengren, K. Johan, Cemazar, Masa and Craik, David J. (2011) The role of conserved Glu residue on cyclotide stability and activity: A structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant. Biochemistry, 50 19: 4077-4086. doi:10.1021/bi2004153
Isolation and characterization of Bioactive Cyclotides from Viola labrilorica
Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010) Isolation and characterization of Bioactive Cyclotides from Viola labrilorica. Helvetica Chimica Acta, 93 11: 2287-2295. doi:10.1002/hlca.201000115
Merging structural biology with chemical biology: Structural Chemistry at Eskitis
Hofmann, Andreas, Wang, Con, Osman, Asiah and Camp, David (2010) Merging structural biology with chemical biology: Structural Chemistry at Eskitis. Structural Chemistry, 21 5: 1117-1129. doi:10.1007/s11224-010-9654-2
Extensions of PDZ domains as important structural and functional elements
Wang, Conan K., Pan, Lifeng, Chen, Jia and Zhang, Mingjie (2010) Extensions of PDZ domains as important structural and functional elements. Protein & Cell, 1 8: 737-751. doi:10.1007/s13238-010-0099-6
Isolation and characterization of cytotoxic cyclotides from Viola tricolor
Tang, Jun, Wang, Conan K., Pan, Xulin, Yan, He, Zeng, Guangzhi, Xu, Wenyan, He, Wenjun, Daly, Norelle L., Craik, David J. and Tan, Ninghua (2010) Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 31 8: 1434-1440. doi:10.1016/j.peptides.2010.05.004
Cyclotides are a component of the innate defense of Oldenlandia affinis
Mylne, Joshua S, Wang, Conan K, van der Weerden, Nicole L and Craik, David J (2010) Cyclotides are a component of the innate defense of Oldenlandia affinis. Biopolymers, 94 5: 635-646. doi:10.1002/bip.21419
Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes
Wang, C. K., Colgrave, M. L., Ireland, D. C., Kaas, Q and Craik, D. J. (2009) Despite a conserved cystine knot motif, different cyclotides have different membrane binding modes. Biophysical Journal, 97 5: 1471-1481. doi:10.1016/j.bpj.2009.06.032
Isolation and characterization of peptides from momordica cochinchinensis seeds
Chan, L. Y., Wang, C. K., Major, J. M., Greenwood, K. P., Lewis, R. J., Craik, D. J. and Daly, N. L. (2009) Isolation and characterization of peptides from momordica cochinchinensis seeds. JOURNAL OF NATURAL PRODUCTS, 72 8: 1453-1458. doi:10.1021/np900174n
Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T, Hajdu, J, Bohlin, L, Claeson, P, Goransson, U, Rosengren, K. J., Tang, J, Tan, N. H. and Craik, D. J. (2009) Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 284 16: 10672-10683. doi:10.1074/jbc.M900021200
NMRDyn: a program for NMR relaxation studies of protein association
Wang, Conan K., Schirra, Horst Joachim and Craik, David J. (2008) NMRDyn: a program for NMR relaxation studies of protein association. PLoS One, 3 11: e3820-1-e3820-7. doi:10.1371/journal.pone.0003820
Wang, C. K., Kaas, Q., Chiche, L. and Craik, D. J. (2008) CyBase: a database of cyclic protein sequences and structures, with application in protein discovery and engineering. Nucleic Acids Research, 36 SUPPL. 1: D206-D210. doi:10.1093/nar/gkm953
Distribution and evolution of circular miniproteins in flowering plants
Gruber, Christian W., Elliott, Alysha G., Ireland, David C., Delprete, Piero G., Dessein, Steven, Goransson, Ulf, Trabi, Manuela, Wang, Conan K., Kinghorn, Andrew B., Robbrecht, Elmar and Craik, David J. (2008) Distribution and evolution of circular miniproteins in flowering plants. The Plant Cell, 20 9: 2471-2483. doi:10.1105/tpc.108.062331
The anthelmintic activity of the cyclotides: Natural variants with enhanced activity
Colgrave, Michelle L., Kotze, Andrew C., Ireland, David C., Wang, Conan K. and Craik, David J. (2008) The anthelmintic activity of the cyclotides: Natural variants with enhanced activity. ChemBioChem, 9 12: 1939-1945. doi:10.1002/cbic.200800174
Simonsen, S. M., Sando, L., Rosengren, K. J., Wang, C. K., Colgrave, M. L., Daly, N. L. and Craik, D. J. (2008) Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. Journal of Biological Chemistry, 283 15: 9805-9813. doi:10.1074/jbc.M709303200
ConoServer, a database for conopeptide sequences and structures
Kaas, Quentin, Westermann, Jan, Halai, Reena, Wang, Conan and Craik, David J. (2008) ConoServer, a database for conopeptide sequences and structures. Bioinformatics, 24 3: 445-446. doi:10.1093/bioinformatics/btm596
Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis
Wang, Conan K. L., Colgrave, Michelle L., Gustafson, Kirk R., Ireland, David C., Goransson, Ulf and Craik, David J. (2008) Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis. Journal of Natural Products, 71 1: 47-52. doi:10.1021/np070393g
Cyclotides as natural anti-HIV agents
Ireland, David C., Wang, Conan K., Wilson, Jennifer A., Gustafson, Kirk R. and Craik, David J. (2008) Cyclotides as natural anti-HIV agents. Biopolymers: Peptide Science, 90 1: 51-60. doi:10.1002/bip.20886
CyBase: a database of cyclic protein sequence and structure
Mulvenna, J. P., Wang, C. and Craik, D. J. (2006) CyBase: a database of cyclic protein sequence and structure. Nucleic Acids Research, 34 Sp. Iss. SI: D192-D194. doi:10.1093/nar/gkj005
Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae
Chen, B., Colgrave, M. L., Wang, C. N. and Craik, D. J. (2006) Cycloviolacin H4, a hydrophobic cyclotide from Viola hederaceae. Journal of Natural Products, 69 1: 23-28. doi:10.1021/np050317i
The cyclotide family of circular miniproteins: Nature's combinatorial peptide template
Craik, D. J., Cemazar, M., Wang, C. K. L. and Daly, N. L. (2006) The cyclotide family of circular miniproteins: Nature's combinatorial peptide template. Biopolymers, 84 3: 250-266. doi:10.1002/hip.20451
A journey alongside cyclosporin on the road to peptide oral bioavailability
Wang, Conan and Craik, David (2018). A journey alongside cyclosporin on the road to peptide oral bioavailability. In: 35th European Peptide Symposium, Dublin City University, Ireland, (S59-S59). 26-31 August 2018.
Henriques, Sonia Troeira, Peacock, Hayden, Benfield, Aurelie H., Wang, Conan and Craik, David (2018). Is the mirror image a true reflection? Lipid chirality in the activity of the prototypic cyclotide kalata B1. In: 35th European Peptide Symposium, Dublin City University, Ireland, (S69-S69). 26-31 August 2018.
Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons
Huang, Yen-Hua, Passioura, Toby, Peacock, Hayden, Henriques, Sonia Troeira, Wang, Conan, Kaas, Quentin, Suga, Hiroaki and Craik, David (2018). Targeting the coiled-coil domain of BCR-ABL1 kinase with new weapons. In: 35th European Peptide Symposium, Dublin City University, Ireland, (S160-S160). 26-31 August 2018.
Wang, C. K., Gruber, C. W., Cernazar, M., Siatskas, C., Tagore, P., Sun, G., Wang, S., Bernard, C. and Craik, D. J. (2013). Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. In: 23rd American Peptide Symposium, Waikoloa, Hawaii, (300-300). 22-27 June 2013 .
Cyclotides are a component of the innate defense of Oldenlandia affinis
Mylne, Joshua S., Wang, Conan K., van der Weerden, Nicole L. and Craik, David J. (2010). Cyclotides are a component of the innate defense of Oldenlandia affinis. In: Proceedings of the 1st International Conference on Circular Proteins. 1st International Conference on Circular Proteins, Heron Island, Qld, Australia, (635-645). 18-21 October, 2009. doi:10.1002/bip.21419
Structural and functional studies of cyclotides
Wang, Conan (2008). Structural and functional studies of cyclotides PhD Thesis, Institute for Molecular Bioscience, The University of Queensland.
Biocontrol of crown-of-thorns starfish using genomics and proteomics
(2018–2021) ARC Linkage Projects
New drug leads for cholesterol
(2016–2018) NHMRC Project Grant
Bioengineering stable peptide inhibitors of amyloidosis
(2014) UQ Early Career Researcher
(2012–2013) NHMRC Training (Postdoctoral) Fellowship
(2015) Doctor Philosophy — Associate Advisor
Other advisors: