The University of Queensland

Protein expression optimization strategies in E. coli: a tailored approach in strain selection and parallelizing expression conditions

Tang, Shyn Ric, Somasundaram, Balaji and Lua, Linda H. L. (2022). Protein expression optimization strategies in E. coli: a tailored approach in strain selection and parallelizing expression conditions. Insoluble proteins: methods and protocols. (pp. 93-111) edited by Elena Garcia Fruitos and Anna Arı´s Giralt. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1859-2_5

Advances in protein production technologies

Lua, Linda H. L. and Chuan, Yap Pang (2012). Advances in protein production technologies. Biopharmaceutical production technology. (pp. 43-77) edited by Ganapathy Subramanian. Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527653096.ch2

Virus-like particle bioprocessing

Chuan, Yap Pang, Lua, Linda H. L. and Middelberg, Anton P. J. (2012). Virus-like particle bioprocessing. Biopharmaceutical production technology. (pp. 139-163) edited by Ganapathy Subramanian. Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527653096.ch5

Design and optimization of membrane chromatography for monoclonal antibody charge variant separation

Nadar, Sathish, Somasundaram, Balaji, Charry, Marcela, Billakanti, Jagan, Shave, Evan, Baker, Kym and Lua, Linda H. L. (2022). Design and optimization of membrane chromatography for monoclonal antibody charge variant separation. Biotechnology Progress, 38 (6) e3288, 1-15. doi: 10.1002/btpr.3288

Design and production strategies for developing a recombinant butyrylcholinesterase medical countermeasure for Organophosphorus poisoning

Allard, Joanne L., Shields, Katherine A., Munro, Trent P. and Lua, Linda H.L. (2022). Design and production strategies for developing a recombinant butyrylcholinesterase medical countermeasure for Organophosphorus poisoning. Chemico-Biological Interactions, 363 109996, 109996. doi: 10.1016/j.cbi.2022.109996

Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

Yap, Kuok, Du, Junqiao, Rehm, Fabian B. H., Tang, Shyn Ric, Zhou, Yan, Xie, Jing, Wang, Conan K., de Veer, Simon J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2021). Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases. Nature Protocols, 16 (3), 1-23. doi: 10.1038/s41596-020-00483-0

Ambient temperature stable, scalable COVID-19 polymer particle vaccines induce protective immunity

Chen, Shuxiong, Evert, Benjamin, Adeniyi, Adetayo, Salla-Martret, Mercè, Lua, Linda H.-L., Ozberk, Victoria, Pandey, Manisha, Good, Michael F., Suhrbier, Andreas, Halfmann, Peter, Kawaoka, Yoshihiro and Rehm, Bernd H. A. (2021). Ambient temperature stable, scalable COVID-19 polymer particle vaccines induce protective immunity. Advanced Healthcare Materials, 11 (3) 2102089, 2102089. doi: 10.1002/adhm.202102089

Current status and future challenges in transitioning to continuous bioprocessing of virus-like particles

Mittal, Manya, Banerjee, Manidipa, Lua, Linda H. L. and Rathore, Anurag S. (2021). Current status and future challenges in transitioning to continuous bioprocessing of virus-like particles. Journal of Chemical Technology and Biotechnology, 97 (9) jctb.6821, 2376-2385. doi: 10.1002/jctb.6821

Intensified downstream processing of monoclonal antibodies using membrane technology

Nadar, Sathish, Shooter, Gary, Somasundaram, Balaji, Shave, Evan, Baker, Kym and Lua, Linda H.L. (2020). Intensified downstream processing of monoclonal antibodies using membrane technology. Biotechnology Journal, 16 (3) 2000309, 1-11. doi: 10.1002/biot.202000309

To our readers: Important notice

Poland, Gregory A., van Dijk, Nicolette, Altmann, Danny, Borrow, Ray, Hung, Ivan, Ishii, Ken, Jacobsen, Steve, Krammer, Florian, Larson, Heidi, Lua, Linda, Middelberg, Anton, Nelson, Jennifer, Neuzil, Kathy, Nohynek, Hanna, Reingold, Art, van den Hurk, Sylvia, Kennedy, Rick B. and Sadarangani, Sapna (2020). To our readers: Important notice. Vaccine, 38 (35). doi: 10.1016/j.vaccine.2020.07.001

An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides

Yap, Kuok, Du, Junqiao, Looi, Fong Yang, Tang, Shyn Ric, de Veer, Simon J., Bony, Anuja R., Rehm, Fabian B. H., Xie, Jing, Chan, Lai Yue, Wang, Conan K., Adams, David J., Lua, Linda H. L., Durek, Thomas and Craik, David J. (2020). An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides. Green Chemistry, 22 (15), 5002-5016. doi: 10.1039/d0gc01366h

Protein expression in the baculovirus-insect cell expression system

Adeniyi, Adetayo A. and Lua, Linda Hwee-Lin (2020). Protein expression in the baculovirus-insect cell expression system. Methods in Molecular Biology, 2073, 17-37. doi: 10.1007/978-1-4939-9869-2_2

Vaccine Technology VII: beyond the “decade of vaccines”

Kamen, Amine A., Lua, Linda H. L. and Mukhopadhyay, Tarit K. (2019). Vaccine Technology VII: beyond the “decade of vaccines”. Vaccine, 37 (47), 6931-6932. doi: 10.1016/j.vaccine.2019.09.083

Evaluation of process simulation as a decisional tool for biopharmaceutical contract development and manufacturing organizations

Pleitt, Kristina, Somasundaram, Balaji, Johnson, Bradley, Shave, Evan and Lua, Linda H.L. (2019). Evaluation of process simulation as a decisional tool for biopharmaceutical contract development and manufacturing organizations. Biochemical Engineering Journal, 150 107252, 107252. doi: 10.1016/j.bej.2019.107252

Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8(+) T Cell and Antibody Responses

Pattinson, David J., Apte, Simon H., Wibowo, Nani, Chuan, Yap P., Rivera-Hernandez, Tania, Groves, Penny L., Lua, Linda H., Middelberg, Anton P. J. and Doolan, Denise L. (2019). Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8(+) T Cell and Antibody Responses. Frontiers in Cellular and Infection Microbiology, 9 (JUN) 215, 215. doi: 10.3389/fcimb.2019.00215

Synthetic biology for bioengineering virus-like particle vaccines

Charlton Hume, Hayley K., Vidigal, João, Carrondo, Manuel J. T., Middelberg, Anton P. J., Roldão, António and Lua, Linda H. L. (2019). Synthetic biology for bioengineering virus-like particle vaccines. Biotechnology and Bioengineering, 116 (4), 919-935. doi: 10.1002/bit.26890

Progression of continuous downstream processing of monoclonal antibodies: current trends and challenges

Somasundaram, Balaji, Pleitt, Kristina, Shave, Evan, Baker, Kym and Lua, Linda H. L. (2018). Progression of continuous downstream processing of monoclonal antibodies: current trends and challenges. Biotechnology and Bioengineering, 115 (12), 2893-2907. doi: 10.1002/bit.26812

Antibody-binding, antifouling surface coatings based on recombinant expression of zwitterionic EK peptides

Walker, Julia A., Robinson, Kye J., Munro, Christopher, Gengenbach, Thomas, Muller, David A., Young, Paul R., Lua, Linda H. L. and Corrie, Simon R. (2018). Antibody-binding, antifouling surface coatings based on recombinant expression of zwitterionic EK peptides. Langmuir, 35 (5) acs.langmuir.8b00810, 1266-1272. doi: 10.1021/acs.langmuir.8b00810

Vaccine Technology VI: innovative and integrated approaches in vaccine development

Palomares, Laura A., Mukhopadhyay, Tarit K., Genzel, Yvonne, Lua, Linda H.L. and Cox, Manon M.J. (2018). Vaccine Technology VI: innovative and integrated approaches in vaccine development. Vaccine, 36 (22), 3061-3063. doi: 10.1016/j.vaccine.2018.03.077

Baculovirus-driven protein expression in insect cells: a benchmarking study

Stolt-Bergner, Peggy, Benda, Christian, Bergbrede, Tim, Besir, Hüseyin, Celie, Patrick H. N., Chang, Cindy, Drechsel, David, Fischer, Ariane, Geerlof, Arie, Giabbai, Barbara, van den Heuvel, Joop, Huber, Georg, Knecht, Wolfgang, Lehner, Anita, Lemaitre, Regis, Nordén, Kristina, Pardee, Gwynn, Racke, Ines, Remans, Kim, Sander, Astrid, Scholz, Judith, Stadnik, Magda, Storici, Paola, Weinbruch, Daniel, Zaror, Isabel, Lua, Linda H. L. and Suppmann, Sabine (2018). Baculovirus-driven protein expression in insect cells: a benchmarking study. Journal of Structural Biology, 203 (2), 71-80. doi: 10.1016/j.jsb.2018.03.004

Preface: Biosecurity

Lua, Linda H. L. and Fooks, Anthony R. (2017). Preface: Biosecurity. Vaccine, 35 (44), 5947-5948. doi: 10.1016/j.vaccine.2017.08.077

Evaluation of three adjuvants with respect to both adverse effects and the efficacy of antibody production to the Bm86 protein

Petermann, Julie, Bonnefond, Romain, Mermoud, Isabelle, Rantoen, Dewi, Meynard, Laure, Munro, Christopher, Lua, Linda H. L. and Hue, Thomas (2017). Evaluation of three adjuvants with respect to both adverse effects and the efficacy of antibody production to the Bm86 protein. Experimental and Applied Acarology, 72 (3), 303-315. doi: 10.1007/s10493-017-0156-4

Platform technologies for modern vaccine manufacturing

Charlton Hume, Hayley K. and Lua, Linda H. L. (2017). Platform technologies for modern vaccine manufacturing. Vaccine, 35 (35), 4480-4485. doi: 10.1016/j.vaccine.2017.02.069

Small-molecule inhibitors of the SOX18 transcription factor

Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017). Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 (3), 346-359. doi: 10.1016/j.chembiol.2017.01.003

Is Pichia pastoris a realistic platform for industrial production of recombinant human interferon gamma?

Razaghi, Ali, Tan, Emilyn, Lua, Linda H. L., Owens, Leigh, Karthikeyan, O. P. and Heimann, Kirsten (2017). Is Pichia pastoris a realistic platform for industrial production of recombinant human interferon gamma?. Biologicals, 45, 52-60. doi: 10.1016/j.biologicals.2016.09.015

Modular virus-like particles for sublingual vaccination against group A streptococcus

Seth, Arjun, Kong, Il Gyu, Lee, Su-Hyun, Yang, Jin-Young, Lee, Yong-Soo, Kim, Yeji, Wibowo, Nani, Middelberg, Anton P.J., Lua, Linda H.L. and Kweon, Mi-Na (2016). Modular virus-like particles for sublingual vaccination against group A streptococcus. Vaccine, 34 (51), 6472-6480. doi: 10.1016/j.vaccine.2016.11.008

Structural-based designed modular capsomere comprising HA1 for low-cost poultry influenza vaccination

Waneesorn, Jarurin, Wibowo, Nani, Bingham, John, Middelberg, Anton P. J. and Lua, Linda H.L. (2016). Structural-based designed modular capsomere comprising HA1 for low-cost poultry influenza vaccination. Vaccine, 36 (22), 3064-3071. doi: 10.1016/j.vaccine.2016.11.058

Integrated molecular and bioprocess engineering for bacterially produced immunogenic modular virus-like particle vaccine displaying 18 kDa rotavirus antigen

Tekewe, Alemu, Fan, Yuanyuan, Tan, Emilyn, Middelberg, Anton P. J. and Lua, Linda H. L. (2016). Integrated molecular and bioprocess engineering for bacterially produced immunogenic modular virus-like particle vaccine displaying 18 kDa rotavirus antigen. Biotechnology and Bioengineering, 114 (2), 397-406. doi: 10.1002/bit.26068

Design strategies to address the effect of hydrophobic epitope on stability and in vitro assembly of modular virus-like particle

Tekewe, Alemu, Connors, Natalie K., Middelberg, Anton P. J. and Lua, Linda H. L. (2016). Design strategies to address the effect of hydrophobic epitope on stability and in vitro assembly of modular virus-like particle. Protein Science, 25 (8), 1507-1516. doi: 10.1002/pro.2953

Non-chromatographic preparation of a bacterially produced single-shot modular virus-like particle capsomere vaccine for avian influenza

Wibowo, Nani, Wu, Yang, Fan, Yuanyuan, Meers, Joanne, Lua, Linda H. L. and Middelberg, Anton P. J. (2015). Non-chromatographic preparation of a bacterially produced single-shot modular virus-like particle capsomere vaccine for avian influenza. Vaccine, 33 (44), 5960-5965. doi: 10.1016/j.vaccine.2015.08.100

Synthetic biology design to display an 18 kDa rotavirus large antigen on a modular virus-like particle

Lua, Linda H.L., Fan, Yuanyuan, Chang, Cindy, Connors, Natalie K. and Middelberg, Anton P.J. (2015). Synthetic biology design to display an 18 kDa rotavirus large antigen on a modular virus-like particle. Vaccine, 33 (44), 5937-5944. doi: 10.1016/j.vaccine.2015.09.017

Vaccine

Wibowo, Nani, Lua, Linda Hwee-Lin, Jungbauer, Alois and Ma, Guanghui (2015). Vaccine. Vaccine Engineering, 33 (44), 5889-5889. doi: 10.1016/j.vaccine.2015.10.002

Insert engineering and solubility screening improves recovery of virus-like particle subunits displaying hydrophobic epitopes

Abidin, R.S., Lua, L.H.L., Middelberg, A.P.J. and Sainsbury, F. (2015). Insert engineering and solubility screening improves recovery of virus-like particle subunits displaying hydrophobic epitopes. Protein Science, 24 (11), 1820-1828. doi: 10.1002/pro.2775

Biomolecular engineering of virus-like particles aided by computational chemistry methods

Zhang, Lin, Lua, Linda H. L., Middelberg, Anton P. J., Sun, Yan and Connors, Natalie K. (2015). Biomolecular engineering of virus-like particles aided by computational chemistry methods. Chemical Society Reviews, 44 (23), 8608-8618. doi: 10.1039/c5cs00526d

A rapid and simple screening method to identify conditions for enhanced stability of modular vaccine candidates

Tekewe, Alemu, Connors, Natalie K., Sainsbury, Frank, Wibowo, Nani, Lua, Linda H. L. and Middelberg, Anton P. J. (2015). A rapid and simple screening method to identify conditions for enhanced stability of modular vaccine candidates. Biochemical Engineering Journal, 100, 50-58. doi: 10.1016/j.bej.2015.04.004

Non-Carrier Nanoparticles Adjuvant ModularProtein Vaccine in a Particle-Dependent Manner

Seth, Arjun, Ritchie, Fiona K., Wibowo, Nani, Lua, Linda H. L. and Middelberg, Anton P. J. (2015). Non-Carrier Nanoparticles Adjuvant ModularProtein Vaccine in a Particle-Dependent Manner. PLoS One, 10 (3) 0117203, e0117203-e0117203. doi: 10.1371/journal.pone.0117203

Development of picornavirus-like particle vaccines

Somasundaram, Balaji and Lua, Linda H. L. (2015). Development of picornavirus-like particle vaccines. Pharmaceutical Bioprocessing, 3 (1), 45-49. doi: 10.4155/pbp.14.39

Characterizing Enterovirus 71 and Coxsackievirus A16 Virus-like Particles Production in Insect Cells

Somasundaram, Balaji, Chang, Cindy, Fan, Yuan Y., Lim, Pei-Yin, Cardosa, Jane and Lua, Linda (2015). Characterizing Enterovirus 71 and Coxsackievirus A16 Virus-like Particles Production in Insect Cells. Methods, 95, 38-45. doi: 10.1016/j.ymeth.2015.09.023

The economics of virus-like particle and capsomere vaccines

Chuan, Yap P., Wibowo, Nani, Lua, Linda H. L. and Middelberg, Anton P. J. (2014). The economics of virus-like particle and capsomere vaccines. Biochemical Engineering Journal, 90, 255-263. doi: 10.1016/j.bej.2014.06.005

Energetic changes caused by antigenic module insertion in a virus-like particle revealed by experiment and molecular dynamics simulations

Zhang, Lin, Tang, Ronghong, Bai, Shu, Connors, Natalie K., Lua, Linda H. L., Chuan, Yap P., Middelberg, Anton P. J. and Sun, Yan (2014). Energetic changes caused by antigenic module insertion in a virus-like particle revealed by experiment and molecular dynamics simulations. PLoS One, 9 (9) e107313, e107313.1-e107313.12. doi: 10.1371/journal.pone.0107313

Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation

Wibowo, Nani, Chuan, Yap P., Seth, Arjun, Cordoba, Yoann, Lua, Linda H. L. and Middelberg, Anton P. J. (2014). Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation. Vaccine, 32 (29), 3664-3669. doi: 10.1016/j.vaccine.2014.04.043

Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: Extending the potential of broadly cross-protecting epitopes

Wibowo, Nani, Hughes, Fiona K., Fairmaid, Emily J., Lua, Linda H. L., Brown, Lorena E. and Middelberg, Anton P. J. (2014). Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: Extending the potential of broadly cross-protecting epitopes. Vaccine, 32 (29), 3651-3655. doi: 10.1016/j.vaccine.2014.04.062

Bioengineering virus-like particles as vaccines

Lua, Linda H. L., Connors, Natalie K., Sainsbury, Frank, Chuan, Yap P., Wibowo, Nani and Middelberg, Anton P. J. (2014). Bioengineering virus-like particles as vaccines. Biotechnology and Bioengineering, 111 (3), 425-440. doi: 10.1002/bit.25159

Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants

Chuan, Yap P., Wibowo, Nani, Connors, Natalie K., Wu, Yang, Hughes, Fiona K., Batzloff, Michael R., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants. Biotechnology and Bioengineering, Early View (6), 1-9. doi: 10.1002/bit.25172

Virus-like particle bioprocessing: challenges and opportunities

Middelberg, Anton P. J. and Lua, Linda H. L. (2013). Virus-like particle bioprocessing: challenges and opportunities. Pharmaceutical Bioprocessing, 1 (5), 407-409. doi: 10.4155/pbp.13.49

Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle

Anggraeni, Melisa R., Connors, Natalie K., Wu, Yang, Chuan, Yap P., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle. Vaccine, 31 (40), 4428-4435. doi: 10.1016/j.vaccine.2013.06.087

Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines

Connors, Natalie K., Wu, Yang, Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines. Food and Bioproducts Processing, 92 (2), 143-151. doi: 10.1016/j.fbp.2013.08.012

Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine

Chuan, Yap P., Rivera-Hernandez, Tania, Wibowo, Nani, Connors, Natalie K., Wu, Yang, Hughes, Fiona K., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine. Biotechnology and Bioengineering, 110 (9), 2343-2351. doi: 10.1002/bit.24907

Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations

Zhang, Lin, Tang, Ronghong, Bai, Shu, Connors, Natalie K., Lua, Linda H. L., Chuan, Yap P., Middelberg, Anton P. J. and Sun, Yan (2013). Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations. Journal of Physical Chemistry B, 117 (18), 5411-5421. doi: 10.1021/jp311170w

Virus-like particle formulation optimization by miniaturized high-throughput screening

Mohr, Johannes, Chuan, Yap P., Wu, Yang, Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Virus-like particle formulation optimization by miniaturized high-throughput screening. Methods, 60 (3), 248-256. doi: 10.1016/j.ymeth.2013.04.019

Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS)

Rivera-Hernandez, Tania, Hartas, Jon, Wu, Yang, Chuan, Yap P., Lua, Linda H. L., Good, Michael, Batzloff, Michael R. and Middelberg, Anton P. J. (2013). Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS). Vaccine, 31 (15), 1950-1955. doi: 10.1016/j.vaccine.2013.02.013

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

Chen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558

Modular engineering of a microbially-produced viral capsomere vaccine for influenza

Wibowo, Nani, Chuan, Yap P., Lua, Linda H. L. and Middelberg, Anton P. J. (2012). Modular engineering of a microbially-produced viral capsomere vaccine for influenza. Chemical Engineering Science, 103, 12-20. doi: 10.1016/j.ces.2012.04.001

A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines

Middelberg, Anton P.J., Rivera-Hernandez, Tania, Wibowo, Nani, Lua, Linda H.L., Fan, Yuanyuan, Magor, Graham, Chang, Cindy, Chuan, Yap P., Good, Michael F. and Batzloff, Michael R. (2011). A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine, 29 (41), 7154-7162. doi: 10.1016/j.vaccine.2011.05.075

A new bioproduction route for a novel antimicrobial peptide

Tay, Derrick Kok Sing, Rajagopalan, Gobinath, Li, Xiang, Chen, Yu, Linda H.L. Lua and Leong, Susanna Su Jan (2011). A new bioproduction route for a novel antimicrobial peptide. Biotechnology and Bioengineering, 108 (3), 572-581. doi: 10.1002/bit.22970

Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation

Hu, Shu-Hong, Christie, Michelle P., Saez, Natalie J., Latham, Catherine F., Jarrott, Russell, Lua, Linda H. L., Collins, Brett M. and Martin, Jennifer L. (2011). Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America, 108 (3), 1040-1045. doi: 10.1073/pnas.0914906108

Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeres

Chuan, Yap P., Fan, Yuan Y., Lua, Linda H.L. and Middelberg, Anton P.J. (2010). Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeres. Journal of The Royal Society Interface, 7 (44), 409-421. doi: 10.1098/rsif.2009.0175

The Chromatography-Free Release, Isolation and Purification of Recombinant Peptide for Fibril Self-Assembly

Hartmann, B. M., Kaar, W., Yoo, I. K., Lua, L. H. L., Falconer, R. J. and Middelberg, A. P. J. (2009). The Chromatography-Free Release, Isolation and Purification of Recombinant Peptide for Fibril Self-Assembly. Biotechnology and Bioengineering, 104 (5), 973-985. doi: 10.1002/bit.22447

Affinity purification of viral protein having heterogeneous quaternary structure: Modeling the impact of soluble aggregates on chromatographic performance

Lipin, D.I., Raj, A., Lua, L.H.L. and Middelberg, A.P.J. (2009). Affinity purification of viral protein having heterogeneous quaternary structure: Modeling the impact of soluble aggregates on chromatographic performance. Journal of Chromatography A, 1216 (30), 5696-5708. doi: 10.1016/j.chroma.2009.05.082

Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy

Pease, Leonard F., Lipin, Daniel I., Tsai, De-Hao, Zachariah, Michael R., Lua, Linda H. L., Tarlov, Michael J. and Middelberg, Anton P. J. (2009). Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy. Biotechnology and Bioengineering, 102 (3), 845-855. doi: 10.1002/bit.22085

Microbial bio-production of a recombinant stimuli-responsive biosurfactant

Kaar, W., Hartmann, B. M., Fan, Y., Zeng, B., Lua, L. H. L., Dexter, A. F., Falconer, R. J. and Middelberg, A. P. J. (2009). Microbial bio-production of a recombinant stimuli-responsive biosurfactant. Biotechnology and bioengineering, 102 (1), 176-187. doi: 10.1002/bit.22037

Encapsulation of DNA and non-viral protein changes the structure of murine polyomavirus virus-like particles

Lipin, D. I., Chuan, Y. P., Lua, L. H. L. and Middelberg, A. P. J. (2008). Encapsulation of DNA and non-viral protein changes the structure of murine polyomavirus virus-like particles. Archives of Virology, 153 (11), 2027-2039. doi: 10.1007/s00705-008-0220-9

Quaternary size distribution of soluble aggregates of glutathione-S-transferase-purified viral protein as determined by asymmetrical flow field flow fractionation and dynamic light scattering

Lipin, D. I., Lua, L. H. L. and Middelberg, A. P. J. (2008). Quaternary size distribution of soluble aggregates of glutathione-S-transferase-purified viral protein as determined by asymmetrical flow field flow fractionation and dynamic light scattering. Journal of Chromatography A, 1190 (1-2), 204-214. doi: 10.1016/j.chroma.2008.03.032

Quantitative analysis of virus-like particle size and distribution by field-flow Fractionation

Chuan, Y. P., Fan, Y. Y., Lua, L. and Middelberg, A. P. J. (2008). Quantitative analysis of virus-like particle size and distribution by field-flow Fractionation. Biotechnology and Bioengineering, 99 (6), 1425-1433. doi: 10.1002/bit.21710

High-level expression of soluble viral structural protein in escherichia coli

Chuan, Y. P., Lua, L. H. L. and Middelberg, A. P. J. (2008). High-level expression of soluble viral structural protein in escherichia coli. Journal of Biotechnology, 134 (1-2), 64-71. doi: 10.1016/j.jbiotec.2007.12.004

Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch

Kloda, A, Lua, L, Hall, R, Adams, DJ and Martinac, B (2007). Liposome reconstitution and modulation of recombinant N-methyl-D-aspartate receptor channels by membrane stretch. Proceedings of The National Academy of Sciences of The United States of America, 104 (5), 1540-1545. doi: 10.1073/pnas.0609649104

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development

Stack, Colin M., Lowther, Jonathan, Cunningham, Eithne, Donnelly, Sheila, Gardiner, Donald L., Trenholme, Katharine R., Skinner-Adams, Tina S., Teuscher, Franka, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Lua, Linda, Bell, Angus and Dalton, John P. (2007). Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development. Journal of Biological Chemistry, 282 (3), 2069-2080. doi: 10.1074/jbc.M609251200

Demonstration of the protective effects of fluorescent proteins in baculoviruses exposed to ultraviolet light inactivation

McIntosh, A. H., Grasela, J. J., Lua, L. and Braunagel, S. C. (2004). Demonstration of the protective effects of fluorescent proteins in baculoviruses exposed to ultraviolet light inactivation. Journal of Insect Science, 4 (31), 1-9. doi: 10.1673/031.004.3101

Growth, viral production and metabolism of a Helicoverpa zea cell line in serum-free culture

Lua, L. H. L. and Reid, S. (2003). Growth, viral production and metabolism of a Helicoverpa zea cell line in serum-free culture. Cytotechnology, 42 (3), 109-120. doi: 10.1023/B:CYTO.0000015795.46813.44

Sensitivity of Helicoverpa armigera nucleopolyhedrovirus polyhedra to sodium dodecyl sulfate

Lua, L. H. L., Nielsen, L. K. and Reid, S. (2003). Sensitivity of Helicoverpa armigera nucleopolyhedrovirus polyhedra to sodium dodecyl sulfate. Biological Control, 26 (1), 57-67. doi: 10.1016/S1049-9644(02)00116-0

Phenotypic and genotypic analysis of Helicoverpa armigera nucleopolyhedrovirus serially passaged in cell culture

Lua, Linda H. L., Pedrini, Marcia R. S., Reid, Steven, Robertson, Ashley and Tribe, David E. (2002). Phenotypic and genotypic analysis of Helicoverpa armigera nucleopolyhedrovirus serially passaged in cell culture. Journal of General Virology, 83 (4), 945-955. doi: 10.1099/0022-1317-83-4-945

Virus morphogenesis of Helicoverpa armigera nucleopolyhedrovirus in Helicoverpa zea serum-free suspension culture

Lua, L. H. L. and Reid, S. (2000). Virus morphogenesis of Helicoverpa armigera nucleopolyhedrovirus in Helicoverpa zea serum-free suspension culture. Journal of General Virology, 81 (10), 2531-2543. doi: 10.1099/0022-1317-81-10-2531

Sublingual vaccination with self-adjuvanting virus-like particles against Group A streptococcus elicit protective immunity in systemic and mucosal sites: implication for allergen-specific immunotherapy

Kong, I, Seth, A., Yang, J-Y, Lee, S-H, Lee, Y-S, Kim, Y., Middelberg, A., Wibowo, N., Lua, L. and Kweon, M-N (2016). Sublingual vaccination with self-adjuvanting virus-like particles against Group A streptococcus elicit protective immunity in systemic and mucosal sites: implication for allergen-specific immunotherapy. Meeting of the European Academy of Allergy and Clinical Immunology, Vienna, Austria, Jun 11-15, 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

Biomolecular engineering for recombinant sustainable surfactants

Middelberg, Anton, Hartmann, Belinda, Lua, Linda and Kaar, Waltraud (2009). Biomolecular engineering for recombinant sustainable surfactants. Asia Pacific Biochemical Engineering Conference, Kobe, Japan, 24-28 November, 2009. Japan: Society for Biotechnology, Japan. doi: 10.1016/j.jbiosc.2009.08.175

Rapid response bioprocessing of influenza vaccines

Wibowo, Nani, Rivera-Hernandez, Tania, Fan, Yuan-Yuan, Chang, Cindy, Chuan, Yap Pang, Lua, Linda and Middelberg, Anton (2009). Rapid response bioprocessing of influenza vaccines. Asia Pacific Biochemical Engineering Conference, Kobe, Japan, 24-28 November, 2009. Japan: Society for Biotechnology, Japan. doi: 10.1016/j.jbiosc.2009.08.099

Terahertz and conventional analysis of virus-like particle vaccines

Middelberg, Anton, Falconer, Robert, Lua, Linda, Chuan, Yap Pang, Fan, Yuan-Yuan and Zakaria, Hidayatul-Aini (2009). Terahertz and conventional analysis of virus-like particle vaccines. Asia Pacific Biochemical Engineering Conference, Kobe, Japan, 24-28 November, 2009. Japan: Society for Biotechnology, Japan. doi: 10.1016/j.jbiosc.2009.08.203

Optimization of colloid-inspired virus-vaccine processing in cell-free reactors

Chuan, Yap, Lipin, Daniel, Lua, Linda and Middelberg, Anton (2007). Optimization of colloid-inspired virus-vaccine processing in cell-free reactors. Chemeca 2007: Academia and Industry: Strengthening the Profession, Melbourne, Australia., 23-26 September 2007. Barton, Australia: Engineers Australia.

The importance of cholesterol for insect cell growth and baculovirus production

Lua, Linda H. L. and Reid, Steven (2005). The importance of cholesterol for insect cell growth and baculovirus production. 18th Meeting of the European Society of Animal Cell Technology (ESACT), Granada, Spain, 11-14 May 2003. Dordrecht, Netherlands: Springer. doi: 10.1007/1-4020-3103-3_111

Effect of time of harvest of budded virus on the selection of baculovirus FP mutants in cell culture

Lua, Linda H. L. and Reid, Steven (2003). Effect of time of harvest of budded virus on the selection of baculovirus FP mutants in cell culture. Washington, DC 20036 USA: Amer Chemical Soc. doi: 10.1021/bp025577u

The importance of cholesterol for insect cell growth and baculovirus production

Lua, L. H. L. and Reid, S. (2003). The importance of cholesterol for insect cell growth and baculovirus production. European Society for Animal Cell Technology 2003, Granada, Spain, 2003. Spain: European Society for Animal Cell Technology.

Challenges posed by in vitro production of Helicoverpa armigera nucleopolyhedrovirus for use as a biopesticide

Lua, H. L. and Reid, S. (1999). Challenges posed by in vitro production of Helicoverpa armigera nucleopolyhedrovirus for use as a biopesticide. APBioChEC '99, Phuket, Thailand, 15-18 November. Thailand: Thai Society of Biotechnology.

Immunogenic compositions and methods therefor

Middelberg, Anton P. J. and Lua, Linda H. L (2013). Immunogenic compositions and methods therefor. WO2013020183 A1.

VLP BASED VACCINE DELIVERY SYSTEM

Linda Lua and Middelberg, Anton P.J. (2008). VLP BASED VACCINE DELIVERY SYSTEM. WO2008040060.

Method of producing baculovirus

Lua, Linda and Reid, Steven (2005). Method of producing baculovirus. WO2005/045014 A1.