The University of Queensland

Imaging flow cytometric analysis of primary bone marrow erythroblastic islands

Tay, Joshua, Bisht, Kavita, Winkler, Ingrid G. and Levesque, Jean-Pierre (2023). Imaging flow cytometric analysis of primary bone marrow erythroblastic islands. Spectral and imaging cytometry methods and protocols. (pp. 43-61) edited by Natasha S. Barteneva and Ivan A. Vorobjev. New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-3020-4_3

The role of mesenchymal stem cells in hematopoiesis

Levesque, Jean-Pierre, Jacobsen, Rebecca N. and Winkler, Ingrid G. (2017). The role of mesenchymal stem cells in hematopoiesis. The biology and therapeutic application of mesenchymal cells. (pp. 467-480) edited by Kerry Atkinson. Hoboken, NJ, United States: John Wiley and Sons. doi: 10.1002/9781118907474.ch32

Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells

Barbier, Valérie, Nowlan, Bianca, Lévesque, Jean-Pierre and Winkler, Ingrid G. (2012). Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells. Leucocytes: methods and protocols. (pp. 31-43) edited by Ashman, RB. New York, United States: Humana Press. doi: 10.1007/978-1-61779-527-5_3

Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo

Barbier, Valérie, Winkler, Ingrid G., Wadley, Robert and Lévesque, Jean-Pierre (2012). Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo. Leucocytes: methods and protocols. (pp. 45-63) edited by Ashman, RB. New York, United States: Humana Press. doi: 10.1007/978-1-61779-527-5_4

Mobilization of hematopoietic stem cells by depleting bone marrow macrophages

Barbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Paul (2012). Mobilization of hematopoietic stem cells by depleting bone marrow macrophages. In Stem cell mobilization: methods and protocols (pp. 117-137) New York, United States: Humana Press. doi:10.1007/978-1-61779-943-3_11

Mobilization of bone marrow-derived progenitors

Levesque, J.-P., Winkler, I. G., Larsen, S. R. and Rasko, J. E. J. (2007). Mobilization of bone marrow-derived progenitors. Bone Marrow-Derived Progenitors. (pp. 4-36) Berlin, Germany: Springer.

Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development

Salga, Marjorie, Samuel, Selwin G., Tseng, Hsu‐Wen, Gatin, Laure, Girard, Dorothée, Rival, Bastien, Barbier, Valerie, Bisht, Kavita, Shatunova, Svetlana, Debaud, Charlotte, Winkler, Ingrid G., Paquereau, Julie, Dinh, Aurélien, Genêt, Guillaume, Kerever, Sébastien, Abback, Paer‐Sélim, Banzet, Sébastien, Genêt, François, Lévesque, Jean‐Pierre and Alexander, Kylie A. (2023). Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development. Journal of Bone and Mineral Research, 38 (11), 1-18. doi: 10.1002/jbmr.4905

GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection

Foo, Cheng Xiang, Bartlett, Stacey, Chew, Keng Yih, Ngo, Minh Dao, Bielefeldt-Ohmann, Helle, Jayakody Arachchige, Buddhika, Matthews, Benjamin, Reed, Sarah, Wang, Ran, Smith, Christian, Sweet, Matthew J., Burr, Lucy, Bisht, Kavita, Shatunova, Svetlana, Sinclair, Jane E., Parry, Rhys, Yang, Yuanhao, Lévesque, Jean-Pierre, Khromykh, Alexander, Rosenkilde, Mette Marie, Short, Kirsty R. and Ronacher, Katharina (2023). GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection. European Respiratory Journal, 61 (3) 2201306, 1-15. doi: 10.1183/13993003.01306-2022

Inflammasomes and the IL-1 family in bone homeostasis and disease

Tseng, Hsu-Wen, Samuel, Selwin Gabriel, Schroder, Kate, Lévesque, Jean-Pierre and Alexander, Kylie A (2022). Inflammasomes and the IL-1 family in bone homeostasis and disease. Current Osteoporosis Reports, 20 (3), 170-185. doi: 10.1007/s11914-022-00729-8

Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification

Tseng, Hsu‐Wen, Kulina, Irina, Girard, Dorothée, Gueguen, Jules, Vaquette, Cedryck, Salga, Marjorie, Fleming, Whitney, Jose, Beulah, Millard, Susan M., Pettit, Allison R., Schroder, Kate, Thomas, Gethin, Wheeler, Lawrie, Genêt, François, Banzet, Sébastien, Alexander, Kylie A. and Levesque, Jean‐Pierre (2022). Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification. Journal of Bone and Mineral Research, 37 (3), 531-546. doi: 10.1002/jbmr.4482

Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles

Tseng, Hsu-Wen, Girard, Dorothée, Alexander, Kylie A., Millard, Susan M., Torossian, Frédéric, Anginot, Adrienne, Fleming, Whitney, Gueguen, Jules, Goriot, Marie-Emmanuelle, Clay, Denis, Jose, Beulah, Nowlan, Bianca, Pettit, Allison R., Salga, Marjorie, Genêt, François, Bousse-Kerdilès, Marie-Caroline Le, Banzet, Sébastien and Lévesque, Jean-Pierre (2022). Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles. Bone Research, 10 (1) 22, 22. doi: 10.1038/s41413-022-00188-y

Lymphocytes are not required for neurogenic heterotopic ossification development after spinal cord injury

Alexander, Kylie A., Tseng, Hsu-Wen, Kulina, Irina, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Ruitenberg, Marc J. and Lévesque, Jean-Pierre (2022). Lymphocytes are not required for neurogenic heterotopic ossification development after spinal cord injury. Neurotrauma Reports, 3 (1), 87-96. doi: 10.1089/neur.2021.0072

Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues

Millard, Susan M., Heng, Ostyn, Opperman, Khatora S., Sehgal, Anuj, Irvine, Katharine M., Kaur, Simranpreet, Sandrock, Cheyenne J., Wu, Andy C., Magor, Graham W., Batoon, Lena, Perkins, Andrew C., Noll, Jacqueline E., Zannettino, Andrew C.W., Sester, David P., Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J., Summers, Kim M. and Pettit, Allison R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Reports, 37 (8) 110058, 110058. doi: 10.1016/j.celrep.2021.110058

Macrophages form erythropoietic niches and regulate iron homeostasis to adapt erythropoiesis in response to infections and inflammation

Lévesque, Jean-Pierre, Summers, Kim M., Bisht, Kavita, Millard, Susan M., Winkler, Ingrid G. and Pettit, Allison R. (2021). Macrophages form erythropoietic niches and regulate iron homeostasis to adapt erythropoiesis in response to infections and inflammation. Experimental Hematology, 103, 1-14. doi: 10.1016/j.exphem.2021.08.011

Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization

Bisht, Kavita, McGirr, Crystal, Lee, Seo-Youn, Tseng, Hsu-Wen, Fleming, Whitney, Alexander, Kylie A., Matsumoto, Taichi, Barbier, Valérie, Sims, Natalie A., Müller-Newen, Gerhard, Winkler, Ingrid G., Bonig, Halvard and Lévesque, Jean-Pierre (2021). Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization. Leukemia, 36 (2), 333-347. doi: 10.1038/s41375-021-01413-z

In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early

Lévesque, Jean-Pierre, Purton, Louise E., Hidalgo, Andrés, Zon, Leonard, Katayama, Yoshio, Scadden, David, Bowman, Teresa V., Stanley, E. Richard, Lucas, Daniel and Pinho, Sandra (2021). In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early. Experimental Hematology, 101-102, 1-6. doi: 10.1016/j.exphem.2021.08.002

Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches

Lévesque, Jean-Pierre, Summers, Kim M., Millard, Susan, Bisht, Kavita, Winkler, Ingrid G. and Pettit, Allison R. (2021). Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches. Experimental Hematology, 100, 12-31. doi: 10.1016/j.exphem.2021.07.001

Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress

Tay, Joshua, Barbier, Valerie, Helwani, Falak M, Price, Gareth R, Levesque, Jean-Pierre and Winkler, Ingrid G (2021). Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress. Stem Cells, 39 (11), 1532-1545. doi: 10.1002/stem.3438

Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal cord-injured mice in a lesion level-dependent manner

Debaud, Charlotte, Tseng, Hsu-Wen, Chedik, Malha, Kulina, Irina, Genêt, François, Ruitenberg, Marc J. and Levesque, Jean-Pierre (2021). Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal cord-injured mice in a lesion level-dependent manner. Journal of Neurotrauma, 38 (15) neu.2021.0058, 2162-2175. doi: 10.1089/neu.2021.0058

Adhesion to E-selectin primes macrophages for activation through AKT and mTOR

Davies, Julie M., Radford, Kristen J., Begun, Jakob, Levesque, Jean-Pierre and Winkler, Ingrid G. (2021). Adhesion to E-selectin primes macrophages for activation through AKT and mTOR. Immunology and Cell Biology, 99 (6) imcb.12447, 622-639. doi: 10.1111/imcb.12447

Neurogenic heterotopic ossifications recapitulate hematopoietic stem cell niche development within an adult osteogenic muscle environment

Girard, Dorothée, Torossian, Frédéric, Oberlin, Estelle, Alexander, Kylie A., Gueguen, Jules, Tseng, Hsu-Wen, Genêt, François, Lataillade, Jean-Jacques, Salga, Marjorie, Levesque, Jean-Pierre, Le Bousse-Kerdilès, Marie-Caroline and Banzet, Sébastien (2021). Neurogenic heterotopic ossifications recapitulate hematopoietic stem cell niche development within an adult osteogenic muscle environment. Frontiers in Cell and Developmental Biology, 9 611842, 611842. doi: 10.3389/fcell.2021.611842

Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release

Starobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452

Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice

Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy C., Millard, Susan M., Batoon, Lena, Sandrock, Cheyenne J., Ferrari-Cestari, Michelle, Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2021). Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice. Journal of Hematology and Oncology, 14 (1) 3, 1-19. doi: 10.1186/s13045-020-00997-w

Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophils

Tseng, Hsu‐Wen, Kulina, Irina, Salga, Marjorie, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Levesque, Jean‐Pierre and Alexander, Kylie A (2020). Neurogenic heterotopic ossifications develop independently of granulocyte‐colony stimulating factor and neutrophils. Journal of Bone and Mineral Research, 35 (11) jbmr.4118, 2242-2251. doi: 10.1002/jbmr.4118

When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification

Alexander, Kylie A., Tseng, Hsu-Wen, Salga, Marjorie, Genêt, François and Levesque, Jean-Pierre (2020). When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification. Current Osteoporosis Reports, 18 (6), 666-676. doi: 10.1007/s11914-020-00636-w

Bacterial lipopolysaccharides suppress erythroblastic islands and erythropoiesis in the bone marrow in an extrinsic and G- CSF-, IL-1-, and TNF-independent manner

Bisht, Kavita, Tay, Joshua, Wellburn, Rebecca N., McGirr, Crystal, Fleming, Whitney, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Pierre (2020). Bacterial lipopolysaccharides suppress erythroblastic islands and erythropoiesis in the bone marrow in an extrinsic and G- CSF-, IL-1-, and TNF-independent manner. Frontiers in Immunology, 11 583550, 1-16. doi: 10.3389/fimmu.2020.583550

Acute myeloid leukemia chemo-resistance is mediated by E-selectin receptor CD162 in bone marrow niches

Erbani, Johanna, Tay, Joshua, Barbier, Valerie, Levesque, Jean-Pierre and Winkler, Ingrid G. (2020). Acute myeloid leukemia chemo-resistance is mediated by E-selectin receptor CD162 in bone marrow niches. Frontiers in Cell and Developmental Biology, 8 668, 668. doi: 10.3389/fcell.2020.00668

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Barbier, Valerie, Erbani, Johanna, Fiveash, Corrine, Davies, Julie M., Tay, Joshua, Tallack, Michael R., Lowe, Jessica, Magnani, John L., Pattabiraman, Diwakar R., Perkins, Andrew C., Lisle, Jessica, Rasko, John E. J., Levesque, Jean-Pierre and Winkler, Ingrid G. (2020). Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance. Nature Communications, 11 (1) 2042, 2042. doi: 10.1038/s41467-020-15817-5

Imaging flow cytometry reveals that granulocyte colony-stimulating factor treatment causes loss of erythroblastic islands in the mouse bone marrow

Tay, Joshua, Bisht, Kavita, McGirr, Crystal, Millard, Susan M., Pettit, Allison R., Winkler, Ingrid G. and Levesque, Jean-Pierre (2020). Imaging flow cytometry reveals that granulocyte colony-stimulating factor treatment causes loss of erythroblastic islands in the mouse bone marrow. Experimental Hematology, 82, 33-42. doi: 10.1016/j.exphem.2020.02.003

CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient derived strains

Nowlan, Bianca, Williams, Elizabeth D., Doran, Michael R. and Levesque, Jean-Pierre (2020). CD27, CD201, FLT3, CD48, and CD150 cell surface staining identifies long-term mouse hematopoietic stem cells in immunodeficient non-obese diabetic severe combined immune deficient derived strains. Haematologica, 105 (1), 71-82. doi: 10.3324/haematol.2018.212910

Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor

Bisht, Kavita, McGirr, Crystal, Alexander, Kylie A, Fleming, Whitney, Sims, Natalie, Newen, Gerhard Müller-, Winkler, Ingrid G and Levesque, Jean-Pierre (2019). Oncostatin M is a novel niche factor that restrains hematopoietic stem cell mobilization in response to G-CSF and CXCR4 antagonist plerixafor. Blood, 134 (Supplement_1), 4469-4469. doi: 10.1182/blood-2019-127431

Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2

Brennan, Faith H., Jogia, Trisha, Gillespie, Ellen R., Blomster, Linda V., Li, Xaria X., Nowlan, Bianca, Williams, Gail M., Jacobson, Esther, Osborne, Geoff W., Meunier, Frederic A., Taylor, Stephen M., Campbell, Kate E., MacDonald, Kelli P.A., Levesque, Jean-Pierre, Woodruff, Trent M. and Ruitenberg, Marc J. (2019). Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight, 4 (9) e98254. doi: 10.1172/jci.insight.98254

Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury

Alexander, Kylie A., Tseng, Hsu-Wen, Fleming, Whitney, Jose, Beulah, Salga, Marjorie, Kulina, Irina, Millard, Susan M., Pettit, Allison R., Genet, Francois and Levesque, Jean-Pierre (2019). Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury. Frontiers in Immunology, 10 (MAR) 377. doi: 10.3389/fimmu.2019.00377

HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR

Bisht, Kavita, Brunck, Marion E., Matsumoto, Taichi, McGirr, Crystal, Nowlan, Bianca, Fleming, Whitney, Keech, Thomas, Magor, Graham, Perkins, Andrew C., Davies, Julie, Walkinshaw, Gail, Flippin, Lee, Winkler, Ingrid G. and Levesque, Jean-Pierre (2019). HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR. Blood Advances, 3 (3), 406-418. doi: 10.1182/bloodadvances.2018017566

Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice

Salga, Marjorie, Tseng, Hsu-Wen, Alexander, Kylie A., Jose, Beulah, Vaquette, Cedryck, Debaud, Charlotte, Gatin, Laure, Genêt, François and Levesque, Jean-Pierre (2019). Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice. Annals of Physical and Rehabilitation Medicine, 62 (3), 189-192. doi: 10.1016/j.rehab.2019.01.005

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

Kaur, Simranpreet, Raggatt, Liza J., Millard, Susan M., Wu, Andy C., Batoon, Lena, Jacobsen, Rebecca N., Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean-Pierre and Pettit, Allison R. (2018). Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. Blood, 132 (7), 735-749. doi: 10.1182/blood-2018-01-829663

Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms

Levesque, Jean-Pierre, Sims, Natalie A., Pettit, Allison R., Alexander, Kylie A., Tseng, Hsu-Wen, Torossian, Frédéric, Genêt, François, Lataillade, Jean-Jacques and Le Bousse-Kerdilès, Marie-Caroline (2017). Macrophages Driving Heterotopic Ossification: Convergence of Genetically-Driven and Trauma-Driven Mechanisms. Journal of Bone and Mineral Research, 33 (2), 365-366. doi: 10.1002/jbmr.3346

Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications

Torossian, Frédéric, Guerton, Bernadette, Anginot, Adrienne, Alexander, Kylie A., Desterke, Christophe , Soave, Sabrina, Tseng, Hsu-Wen, Arouche, Nassim, Boutin, Laetitia, Kulina, Irina, Salga, Marjorie, Jose, Beulah, Pettit, Allison R., Clay, Denis, Rochet, Nathalie, Vlachos, Erica, Genet, Guillaume, Debaud, Charlotte, Denormandie, Philippe, Genet, François, Sims, Natalie A., Banzet, Sébastien, Levesque, Jean-Pierre, Lataillade, Jean-Jacques and Le Bousse-Kerdilès, Marie-Caroline (2017). Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight, 2 (21) e96034. doi: 10.1172/jci.insight.96034

CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair

Batoon, Lena, Millard, Susan Marie, Wullschleger, Martin Eduar, Preda, Corina, Wu, Andy Chiu-Ku, Kaur, Simranpreet, Tseng, Hsu-Wen, Hume, David Arthur, Levesque, Jean-Pierre, Raggatt, Liza Jane and Pettit, Allison Robyn (2017). CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials, 196, 51-66. doi: 10.1016/j.biomaterials.2017.10.033

Peripheral denervation participates in heterotopic ossification in a spinal cord injury model

Debaud, Charlotte, Salga, Marjorie, Begot, Laurent, Holy, Xavier, Chedik, Malha, de l'Escalopier, Nicolas, Torossian, Frederic, Levesque, Jean-Pierre, Lataillade, Jean-Jacques, Le Bousse-Kerdiles, Marie-Caroline and Genet, Francois (2017). Peripheral denervation participates in heterotopic ossification in a spinal cord injury model. PLoS One, 12 (8) e0182454, e0182454. doi: 10.1371/journal.pone.0182454

HIF-1α-stabilizing agent FG-4497 rescues human CD34+ cell mobilization in response to G-CSF in immunodeficient mice

Nowlan, Bianca, Futrega, Kathryn, Brunck, Marion, Walkinshaw, Gail, Flippin, Lee E., Doran, Michael R. and Levesque, Jean-Pierre (2017). HIF-1α-stabilizing agent FG-4497 rescues human CD34+ cell mobilization in response to G-CSF in immunodeficient mice. 0301-472X, 52, 50-55. doi: 10.1016/j.exphem.2017.05.004

Engineering a humanized bone organ model in mice to study bone metastases

Martine, Laure C., Holzapfel, Boris M., McGovern, Jacqui A., Wagner, Ferdinand, Quent, Verena M., Hesami, Parisa, Wunner, Felix M., Vaquette, Cedryck, De-Juan-Pardo, Elena M., Brown, Toby D., Nowlan, Bianca, Wu, Dan Jing, Hutmacher, Cosmo Orlando, Moi, Davide, Oussenko, Tatiana, Piccinini, Elia, Zandstra, Peter W., Mazzieri, Roberta, Levesque, Jean-Pierre, Dalton, Paul D., Taubenberger, Anna V. and Hutmacher, Dietmar W. (2017). Engineering a humanized bone organ model in mice to study bone metastases. Nature Protocols, 12 (4), 639-663. doi: 10.1038/nprot.2017.002

Cellular players of hematopoietic stem cell mobilization in the bone marrow niche

Tay, Joshua, Levesque, Jean‑Pierre and Winkler, Ingrid G. (2017). Cellular players of hematopoietic stem cell mobilization in the bone marrow niche. International Journal of Hematology, 105 (2), 129-140. doi: 10.1007/s12185-016-2162-4

It takes nerve to fight back: the significance of neural innervation of the bone marrow and spleen for immune function

Jung, Won-Cheol, Levesque, Jean-Pierre and Ruitenberg, Marc J. (2017). It takes nerve to fight back: the significance of neural innervation of the bone marrow and spleen for immune function. Seminars in Cell and Developmental Biology, 61, 60-70. doi: 10.1016/j.semcdb.2016.08.010

Cell adhesion molecules in normal and malignant hematopoiesis: from bench to bedside

Levesque, Jean-Pierre and Winkler, Ingrid G. (2016). Cell adhesion molecules in normal and malignant hematopoiesis: from bench to bedside. Current Stem Cell Reports, 2 (4), 356-367. doi: 10.1007/s40778-016-0066-0

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Kaur, Simranpreet, Raggatt, Liza Jane, Batoon, Lena, Hume, David Arthur, Levesque, Jean-Pierre and Pettit, Allison Robyn (2016). Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches. Seminars in Cell and Developmental Biology, 61, 12-21. doi: 10.1016/j.semcdb.2016.08.009

A validated preclinical animal model for primary bone tumor research

Wagner, Ferdinand, Holzapfel, Boris M., Thibaudeau, Laure, Straub, Melanie, Ling, Ming-Tat, Grifka, Joachim, Loessner, Daniela, Levesque, Jean-Pierre and Hutmacher, Dietmar W. (2016). A validated preclinical animal model for primary bone tumor research. The Journal of Bone and Joint Surgery, 98 (11), 916-925. doi: 10.2106/JBJS.15.00920

CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer

Wu, Andy C., He, Yaowu, Broomfield, Amy, Paatan, Nicoll J., Harrington, Brittney S., Tseng, Hsu-Wen, Beaven, Elizabeth A., Kiernan, Deirdre M., Swindle, Peter, Clubb, Adrian B., Levesque, Jean-Pierre, Winkler, Ingrid G., Ling, Ming-Tat, Srinivasan, Bhuvana, Hooper, John D. and Pettit, Allison R. (2016). CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer. Journal of Pathology, 239 (2), 218-230. doi: 10.1002/path.4718

Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak

Winkler, Ingrid G., Wiercinska, Eliza, Barbier, Valerie, Nowlan, Bianca, Bonig, Halvard and Levesque, Jean-Pierre (2016). Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak. Experimental Hematology, 44 (4), 303-314.e1. doi: 10.1016/j.exphem.2016.01.001

Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouse

Jacobsen, Rebecca N., Nowlan, Bianca, Brunck, Marion E., Barbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Pierre (2016). Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouse. Experimental Hematology, 44 (3), 207-212.e4. doi: 10.1016/j.exphem.2015.11.004

Filling the void: allogeneic myeloid cells for transplantation

Schwaber, Jessica L., Brunck, Marion E., Levesque, Jean-Pierre and Nielsen, Lars K. (2015). Filling the void: allogeneic myeloid cells for transplantation. Current Opinion in Hematology, 23 (1), 72-77. doi: 10.1097/MOH.0000000000000205

Tissue engineered humanized bone supports human hematopoiesis in vivo

Holzapfel, Boris M., Hutmacher, Dietmar W., Nowlan, Bianca, Barbier, Valerie, Thibaudeau, Laure, Theodoropoulos, Christina, Hooper, John D., Loessner, Daniela, Clements, Judith A., Russell, Pamela J., Pettit, Allison R., Winkler, Ingrid G. and Levesque, Jean-Pierre (2015). Tissue engineered humanized bone supports human hematopoiesis in vivo. Biomaterials, 61, 103-114. doi: 10.1016/j.biomaterials.2015.04.057

Concise review: Humanized models of tumor immunology in the 21st century: Convergence of cancer research and tissue engineering

Holzapfel, Boris Michael, Wagner, Ferdinand, Thibaudeau, Laure, Levesque, Jean-Pierre and Hutmacher, Dietmar Werner (2015). Concise review: Humanized models of tumor immunology in the 21st century: Convergence of cancer research and tissue engineering. Stem Cells, 33 (6), 1696-1704. doi: 10.1002/stem.1978

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle

Genet, Francois, Kulina, Irina, Vaquette, Cedryck, Torossian, Frederic, Millard, Susan, Pettit, Allison R., Sims, Natalie A., Anginot, Adrienne, Guerton, Bernadette, Winkler, Ingrid G., Barbier, Valerie, Lataillade, Jean-Jacques, Le Bousse-Kerdiles, Marie-Caroline, Hutmacher, Dietmar W. and Levesque, Jean-Pierre (2015). Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle. Journal of Pathology, 236 (2), 229-240. doi: 10.1002/path.4519

Macrophages and regulation of erythropoiesis

Jacobsen, Rebecca N., Perkins, Andrew C. and Levesque, Jean-Pierre (2015). Macrophages and regulation of erythropoiesis. Current Opinion in Hematology, 22 (3), 212-219. doi: 10.1097/MOH.0000000000000131

Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML

Forristal, C. E., Brown, A. L., Helwani, F. M., Winkler, I. G., Nowlan, B., Barbier, V., Powell, R. J., Engler, G. A., Diakiw, S. M., Zannettino, A. C. W., Martin, S., Pattabiraman, D., D'Andrea, R. J., Lewis, I. D. and Levesque, J. P. (2015). Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia, 29 (10), 2075-2085. doi: 10.1038/leu.2015.102

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α

Forristal, C. E., Nowlan, B., Jacobsen, R. N., Barbier, V., Walkinshaw, G., Walkley, C. R., Winkler, I. G. and Levesque, J. P. (2015). HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α. Leukemia, 29 (6), 1366-1378. doi: 10.1038/leu.2015.8

Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse

Jacobsen, Rebecca N., Forristal, Catherine E., Raggatt, Liza J., Nowlan, Bianca, Barbier, Valerie, Kaur, Simranpreet, van Rooijen, Nico, Winkler, Ingrid G., Pettit, Allison R. and Levesque, Jean-Pierre (2014). Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse. Experimental Hematology, 42 (7), 547-561. doi: 10.1016/j.exphem.2014.03.009

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

Pattabiraman, Diwakar R., McGirr, Crystal, Shakhbazov, Konstantin, Barbier, Valerie, Krishnan, Keerthana, Mukhopadhyay, Pamela, Hawthorne, Paula, Trezise, Ann, Ding, Jianmin, Grimmond, Sean M., Papathanasiou, Peter, Alexander, Warren S., Perkins, Andrew C., Levesque, Jean-Pierre, Winkler, Ingrid G. and Gonda, Thomas J. (2014). Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes. Blood, 123 (17), 2682-2690. doi: 10.1182/blood-2012-02-413187

Targeting the hypoxia-sensing pathway in clinical hematology

Forristal, Catherine E. and Levesque, Jean-Pierre (2014). Targeting the hypoxia-sensing pathway in clinical hematology. Stem Cells Translational Medicine, 3 (2), 135-140. doi: 10.5966/sctm.2013-0134

Engraftment outcomes after HPC co-culture with mesenchymal stromal cells and osteoblasts

Cook, Matthew M., Doran, Michael R., Kollar, Katarina, Barbier, Valerie, Winkler, Ingrid G., Levesque, Jean-Pierre, Brooke, Gary and Atkinson, Kerry (2013). Engraftment outcomes after HPC co-culture with mesenchymal stromal cells and osteoblasts. Journal of Clinical Medicine, 2 (3), 115-135. doi: 10.3390/jcm2030115

It takes nerves to recover from chemotherapy

Levesque, Jean-Pierre and Winkler, Ingrid G. (2013). It takes nerves to recover from chemotherapy. Nature Medicine, 19 (6), 669-671. doi: 10.1038/nm.3231

A niche in a dish: pericytes support HSC

Levesque, Jean-Pierre (2013). A niche in a dish: pericytes support HSC. Blood, 121 (15), 2816-2818. doi: 10.1182/blood-2013-02-485144

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

Oancea, Iulia, Png, Chin Wen, Das, Indrajit, Lourie, Rohan, Winkler, Ingrid G., Eri, Rajaraman, Subramaniam, Nathan, Jinnah, H. A., McWhinney, Brett C., Levesque, Jean-Pierre, McGuckin, Michael A., Duley, John A. and Florin, Timothy H. J. (2013). A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity. Gut, 62 (4), 594-605. doi: 10.1136/gutjnl-2012-302274

B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2

Winkler, Ingrid G., Bendall, Linda J., Forristal, Catherine E., Helwani, Falak, Nowlan, Bianca, Barbier, Valerie, Shen, Yi, Cisterne, Adam, Sedger, Lisa M. and Levesque, Jean-Pierre (2013). B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2. Haematologica, 98 (3), 325-333. doi: 10.3324/haematol.2012.069260

Nichotherapy for stem cells: there goes the neighborhood

Levesque, Jean-Pierre, Winkler, Ingrid G. and Rasko, John E. J. (2013). Nichotherapy for stem cells: there goes the neighborhood. BioEssays, 35 (3), 183-190. doi: 10.1002/bies.201200111

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

Forristal, Catherine E., Winkler, Ingrid G., Nowlan, Bianca, Barbier, Valerie, Walkinshaw, Gail and Levesque, Jean-Pierre (2013). Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Blood, 121 (5), 759-769. doi: 10.1182/blood-2012-02-408419

E-selectin, a key regulator of the division of hematopoietic stem cells and their resistance to chemotherapy

Levesque, Jean-Pierre and Winkler, Ingrid G. (2013). E-selectin, a key regulator of the division of hematopoietic stem cells and their resistance to chemotherapy. Medecine/Sciences, 29 (3), 249-251. doi: 10.1051/medsci/2013293007

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor

Karpova, D., Dauber, K., Spohn, G., Chudziak, D., Wiercinska, E., Schulz, M., Pettit, A. R., Levesque, J. P., Romagnoli, B., Patel, K., Chevalier, E., Dembowsky, K. and Bonig, H. (2013). The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor. Leukemia, 27 (12), 2322-2331. doi: 10.1038/leu.2013.266

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

Winkler, Ingrid G., Barbier, Valerie, Nowlan, Bianca, Jacobsen, Rebecca N., Forristal, Catherine E., Patton, John T., Magnani, John L. and Levesque, Jean-Pierre (2012). Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nature Medicine, 18 (11), 1651-1657. doi: 10.1038/nm.2969

Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation

Winkler, I. G., Pettit, A. R., Raggatt, L. J., Jacobsen, R. N., Forristal, C. E., Barbier, V., Nowlan, B., Cisterne, A., Bendall, L. J., Sims, N. A. and Levesque, J-P. (2012). Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia, 26 (7), 1594-1601. doi: 10.1038/leu.2012.17

N(o)-cadherin role for HSCs

Levesque, Jean-Pierre (2012). N(o)-cadherin role for HSCs. Blood, 120 (2), 237-238. doi: 10.1182/blood-2012-05-431148

How I treat patients who mobilize hematopoietic stem cells poorly

To, L. Bik, Levesque, Jean-Pierre and Herbert, Kirsten E. (2011). How I treat patients who mobilize hematopoietic stem cells poorly. Blood, 118 (17), 4530-4540. doi: 10.1182/blood-2011-06-318220

Mobilisation strategies for normal and malignant cells

To, L. Bik, Levesque, Jean-Pierre, Herbert, Kirsten E., Winkler, Ingrid G., Bendall, Linda J., Hiwase, Devendra K., Antonenas, Vicki, Rice, Alison M., Gottlieb, David, Mills, Anthony K., Rasko, John E. J., Larsen, Stephen, Beligaswatte, Ashanka, Nilsson, Susan K., Cooney, Julian P., Cambareri, Antony C. and Lewis, Ian D. (2011). Mobilisation strategies for normal and malignant cells. Pathology, 43 (6), 547-565. doi: 10.1097/PAT.0b013e32834a9eb8

How we mobilize haemopoietic stem cells

Herbert, K.E., Levesque, J.P., Mills, A.K., Gottlieb, D.J., Cooney, J., Szer, J., Rasko, J. and To, L.B. (2011). How we mobilize haemopoietic stem cells. Internal Medicine Journal, 41 (8), 588-594. doi: 10.1111/j.1445-5994.2011.02544.x

Hierarchy of immature hematopoietic cells related to blood flow and niche

Levesque, Jean-Pierre and Winkler, Ingrid G. (2011). Hierarchy of immature hematopoietic cells related to blood flow and niche. Current Opinion in Hematology, 18 (4), 220-225. doi: 10.1097/MOH.0b013e3283475fe7

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Winkler, Ingrid G., Sims, Natalie A., Pettit, Allison R., Barbier, Valérie, Nowlan, Bianca, Helwani, Falak, Poulton, Ingrid J., van Rooijen, Nico van, Alexander, Kylie A., Raggatt, Liza J. and Levesque, Jean-Pierre (2010). Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood, 116 (23), 4815-4828. doi: 10.1182/blood-2009-11-253534

The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization

Lévesque, J.-P., Helwani, F. M. and Winkler, I. G. (2010). The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization. Leukemia, 24 (12), 1979-1992. doi: 10.1038/leu.2010.214

Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo

Shen, Yi, Winkler, Ingrid G., Barbier, Valerie, Sims, Natalie A., Hendy, Jean and Lévesque, Jean-Pierre (2010). Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo. PLoS One, 5 (9) e13086, e13086-1-e13086-13. doi: 10.1371/journal.pone.0013086

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: Serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches

Winkler, Ingrid G., Barbier, Valérie, Wadley, Robert, Zannettino, Andrew C. W., Williams, Sharon and Lévesque, Jean-Pierre (2010). Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: Serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood, 116 (3), 375-385. doi: 10.1182/blood-2009-07-233437

38th annual meeting of the international society of experimental hematology

Levesque, Jean-Pierre and Winkler, Ingrid G. (2009). 38th annual meeting of the international society of experimental hematology. Expert Review of Hematology, 2 (6), 645-647. doi: 10.1586/ehm.09.61

Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta

Brooke, Gary, Tong, Hui, Levesque, Jean-Pierre and Atkinson, Kerry (2008). Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta. Stem Cells and Development, 17 (5), 929-940. doi: 10.1089/scd.2007.0156

Mobilization of hematopoietic stem cells: state of the art

Levesque, J-P. J. R. and Winkler, I.G. (2008). Mobilization of hematopoietic stem cells: state of the art. Current Opinion in Organ Transplantation, 13 (1), 53-58. doi: 10.1097/MOT.0b013e3282f42473

The Use of Experimental Murine Models to Assess Novel Agents of Hematopoietic Stem and Progenitor Cell Mobilization

Herbert, K.E., Levesque, J-P., Haylock, D.N. and Prince, M. (2008). The Use of Experimental Murine Models to Assess Novel Agents of Hematopoietic Stem and Progenitor Cell Mobilization. Biology of Blood and Marrow Transplantation, 14 (6), 603-621. doi: 10.1016/j.bbmt.2008.02.003

Granulocyte colony stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells

Herbert, Kirsten, Walkley, Carl R., Winkler, Ingrid G., Hendy, Jean, Olsen, Gemma Haines, Yuan, Yang-Dar, Chandraratna, Roshantha A., Prince, H. Miles, Lévesque, Jean-Pierre and Purton, Louise E. (2007). Granulocyte colony stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells. Cell Therapy and Islet Transplantation, 83 (4), 375-384. doi: 10.1097/01.tp.0000251376.75347.b4

Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow

Levesque, J. P., Winkler, I. G., Hendy, J., Williams, B., Helwani, F., Barbier, V., Nowlan, B. and Nilsson, S. K. (2007). Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow. Stem Cells, 25 (8), 1954-1965. doi: 10.1634/stemcells.2006-0688

Mechanisms of hematopoietic stem cell mobilization: When innate immunity assails the cells that make blood and bone

Winkler, IG and Levesque, JP (2006). Mechanisms of hematopoietic stem cell mobilization: When innate immunity assails the cells that make blood and bone. Experimental Hematology, 34 (8), 996-1009. doi: 10.1016/j.exphem.2006.04.005

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization

Winkler, IG, Hendy, J, Coughlin, P, Horvath, A and Levesque, JP (2005). Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. Journal of Experimental Medicine, 201 (7), 1077-1088. doi: 10.1084/jem.20042299

Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells

Eto, Tetsuya, Winkler, Ingrid, Purton, Louise E. and Levesque, Jean-Pierre (2005). Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells. Experimental Hematology, 33 (2), 232-242. doi: 10.1016/j.exphem.2004.10.018

Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis

Jorgensen-Tye, B, Levesque, JP, Royle, L, Doyonnas, R, Chan, JYH, Dwek, RA, Rudd, PM, Harvey, DJ, Simmons, PJ and Watt, SM (2005). Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis. Tissue Antigens, 65 (3), 220-239. doi: 10.1111/j.1399-0039.2005.00358.x

G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow

Semerad, CL, Christopher, MJ, Liu, FL, Short, B, Simmons, PJ, Winkler, I, Levesque, JP, Chappel, J, Ross, FP and Link, DC (2005). G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood, 106 (9), 3020-3027. doi: 10.1182/blood-2004-01-0272

Characterization of hematopoietic progenitor mobilization in protease-deficient mice

Levesque, JP, Liu, F, Simmons, PJ, Betsuyaku, T, Senior, RM, Pham, C and Link, DC (2004). Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood, 104 (1), 65-72. doi: 10.1182/blood-2003-05-1589

Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1

Winkler, IG, Snapp, KR, Simmons, PJ and Levesque, JP (2004). Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1. Blood, 103 (5), 1685-1692. doi: 10.1182/blood-2003-06-1921

Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells

Levesque, JP, Hendy, J, Winkler, IG, Takamatsu, Y and Simmons, PJ (2003). Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells. Experimental Hematology, 31 (2), 109-117. doi: 10.1016/S0301-472X(02)01028-7

Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by gcsf or cyclophosphamide

Levesque, JP, Hendy, J, Takamatsu, Y, Simmons, PJ and Bendall, LJ (2003). Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by gcsf or cyclophosphamide. Journal of Clinical Investigation, 111 (2), 187-196. doi: 10.1172/JCI200315994

A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29)

Levesque, JP, Takada, Y, Puzon-McLaughlin, W and Simmons, PJ (2002). A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29). Hybridoma and Hybridomics, 21 (4), 253-260. doi: 10.1089/153685902760213868

Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment

Levesque, JP, Hendy, J, Takamatsu, Y, Williams, B, Winkler, IG and Simmons, PJ (2002). Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Experimental Hematology, 30 (5), 440-449. doi: 10.1016/S0301-472X(02)00788-9

Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor

Levesque, Jean-Pierre, Takamatsu, Yasushi, Nilsson, Yasushi, Haylock, Yasushi and Simmons, Yasushi (2001). Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. Blood, 98 (5), 1289-1297. doi: 10.1182/blood.V98.5.1289

Mucin-like molecules as modulators of the survival and proliferation of primitive hematopoietic cells

Simmons, PJ, Levesque, JP and Haylock, DN (2001). Mucin-like molecules as modulators of the survival and proliferation of primitive hematopoietic cells. Hematopoietic Stem Cells 2000 Basic and Clinical Sciences, 938, 196-207.

Role of integrins and selectins in the development and regulation of the hematopoietic system

Lévesque, J. P., Takamatsu, Y., Nilsson, S. K., Haylock, D. N. and Simmons, P. J. (2001). Role of integrins and selectins in the development and regulation of the hematopoietic system. Hematologie, 7 (2), 99-109.

Mobilization of hemopoietic progenitor cells into peripheral blood is associated with vcam-1proteolytic cleavage in the bone marrow

Levesque, J. P., Takamatsu, Y., Nilsson, S. K., Haylock, D. N. and Simmons, P. J. (2000). Mobilization of hemopoietic progenitor cells into peripheral blood is associated with vcam-1proteolytic cleavage in the bone marrow. Blood, 96 (11 PART I).

CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor

Doyonnas, R, Chan, JYH, Butler, LH, Rappold, I, Lee-Prudhoe, JE, Zannettino, ACW, Simmons, PJ, Buhring, HJ, Levesque, JP and Watt, SM (2000). CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor. Journal of Immunology, 165 (2), 840-851. doi: 10.4049/jimmunol.165.2.840

Functionally defined CD164 epitopes are expressed on CD34(+) cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues

Watt, SM, Butler, LH, Tavian, M, Buhring, HJ, Rappold, I, Simmons, PJ, Zannettino, ACW, Buck, D, Fuchs, A, Doyonnas, R, Chan, JYH, Levesque, JP, Peault, B and Roxanis, I (2000). Functionally defined CD164 epitopes are expressed on CD34(+) cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues. Blood, 95 (10), 3113-3124.

CD44 isoforms in normal and leukemic hematopoiesis

Ghaffari, S, Smadja-Joffe, F, Oostendorp, R, Levesque, JP, Dougherty, G, Eaves, A and Eaves, C (1999). CD44 isoforms in normal and leukemic hematopoiesis. Experimental Hematology, 27 (6), 978-993. doi: 10.1016/S0301-472X(99)00023-5

Cytoskeleton and integrin-mediated adhesion signaling in human CD34+ hemopoietic progenitor cells

Levesque, JP and Simmons, PJ (1999). Cytoskeleton and integrin-mediated adhesion signaling in human CD34+ hemopoietic progenitor cells. Experimental Hematology, 27 (4), 579-586. doi: 10.1016/S0301-472X(98)00069-1

PSGL-1-mediated adhesion of human hematopoietic progenitors to P- selectin results in suppression of hematopoiesis

Levesque, JP, Zannettino, ACW, Pudney, M, Niutta, S, Haylock, DN, Snapp, KR, Kansas, GS, Berndt, MC and Simmons, PJ (1999). PSGL-1-mediated adhesion of human hematopoietic progenitors to P- selectin results in suppression of hematopoiesis. Immunity, 11 (3), 369-378. doi: 10.1016/S1074-7613(00)80112-0

Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization

Takamatsu, Y, Simmons, PJ, Moore, RJ, Morris, HA, To, LB and Levesque, JP (1998). Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization. Blood, 92 (9), 3465-3473. doi: 10.1182/blood.v92.9.3465.421k35_3465_3473

Stem cell factor as a single agent induces selective proliferation of the Philadelphia chromosome positive fraction of chronic myeloid leukemia CD34(+) cells

Moore, S, Haylock, DN, Levesque, JP, McDiarmid, LA, Samels, LM, To, LB, Simmons, PJ and Hughes, TP (1998). Stem cell factor as a single agent induces selective proliferation of the Philadelphia chromosome positive fraction of chronic myeloid leukemia CD34(+) cells. Blood, 92 (7), 2461-2470. doi: 10.1182/blood.v92.7.2461.2461_2461_2470

CD44 and hematopoiesis CD44 et hematopoiese

Smadja-Joffe, Florence, Charrad, Rachida-Sihem, Legras, Stéphane, Gadhoum, Zeineb and Lévesque, Jean-Pierre (1998). CD44 and hematopoiesis CD44 et hematopoiese. Hematologie, 4 (5), 339-349.

Mitogenic effect of fibrinogen on hematopoietic cells: Involvement of two distinct specific receptors, MFR and ICAM-1

Heron, A, Levesque, JP, Hatzfeld, A, Kisselev, S, Monier, MN, Krief, P and Hatzfeld, J (1998). Mitogenic effect of fibrinogen on hematopoietic cells: Involvement of two distinct specific receptors, MFR and ICAM-1. Biochemical and Biophysical Research Communications, 246 (1), 231-237. doi: 10.1006/bbrc.1998.8583

Dual control by divalent cations and mitogenic cytokines of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity expressed by human hemopoietic cells

Takamatsu, Y, Simmons, PJ and Levesque, JP (1998). Dual control by divalent cations and mitogenic cytokines of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity expressed by human hemopoietic cells. Cell Adhesion and Communication, 5 (5), 349-366. doi: 10.3109/15419069809010781

The phenomenon of blood stem cell mobilisation

Simmons, PJ, Levesque, JP, Takamatsu, Y and To, LB (1998). The phenomenon of blood stem cell mobilisation. Vox Sanguinis, 74, 103-103.

A rapid streptavidin-capture ELISA specific for the detection of antibodies to feline foamy virus

Winkler, IG, Lochelt, M, Levesque, JP, Bodem, J, Flugel, RM and Flower, RLP (1997). A rapid streptavidin-capture ELISA specific for the detection of antibodies to feline foamy virus. Journal of Immunological Methods, 207 (1), 69-77. doi: 10.1016/S0022-1759(97)00109-9

CD44-mediated adhesiveness of human hematopoietic progenitors to hyaluronan is modulated by cytokines

Legras, S, Levesque, JP, Charrad, R, Morimoto, K, LeBousse, C, Clay, D, Jasmin, C and SmadjaJoffe, F (1997). CD44-mediated adhesiveness of human hematopoietic progenitors to hyaluronan is modulated by cytokines. Blood, 89 (6), 1905-1914. doi: 10.1182/blood.v89.6.1905

Adhesion molecules in haemopoiesis

Simmons, PJ, Levesque, JP and Zannettino, ACW (1997). Adhesion molecules in haemopoiesis. Bailliere's Clinical Haematology, 10 (3), 485-505. doi: 10.1016/S0950-3536(97)80022-4

Mechanisms underlying the mobilisation of primitive haemopoietic progenitors into the peripheral blood

Simmons, P., Levesque, J., Takamatsu, Y. and To, L. (1996). Mechanisms underlying the mobilisation of primitive haemopoietic progenitors into the peripheral blood. Cancer Forum, 20 (4), 269-271.

The dual orchestration of haemopoiesis by adhesive proteins and cytokines

Levesque, J., Haylock, D. and Simmons, P. (1996). The dual orchestration of haemopoiesis by adhesive proteins and cytokines. Cancer Forum, 20 (4), 272-274.

Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34(+) hemopoietic progenitors

Levesque, JP, Haylock, DN and Simmons, PJ (1996). Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34(+) hemopoietic progenitors. Blood, 88 (4), 1168-1176. doi: 10.1182/blood.v88.4.1168.bloodjournal8841168

CD44 and hyaluronan binding by human myeloid cells

SmadjaJoffe, F, Legras, S, Girard, N, Li, Y, Delpech, B, Bloget, F, Morimoto, K, LeBousseKerdiles, C, Clay, D, Jasmin, C and Levesque, JP (1996). CD44 and hyaluronan binding by human myeloid cells. Leukemia & Lymphoma, 21 (5-6), 407-420. doi: 10.3109/10428199609093438

Early Cd34(High) Cells Can Be Separated Into Kithigh Cells in Which Transforming Growth-Factor-Beta (Tgf-Beta) Down-Modulates C-Kit and Kitlow Cells in Which Anti-Tgf-Beta Upmodulates C-Kit

Sansilvestri, P, Cardoso, AA, Batard, P, Panterne, B, Hatzfeld, A, Lim, B, Levesque, JP, Monier, MN and Hatzfeld, J (1995). Early Cd34(High) Cells Can Be Separated Into Kithigh Cells in Which Transforming Growth-Factor-Beta (Tgf-Beta) Down-Modulates C-Kit and Kitlow Cells in Which Anti-Tgf-Beta Upmodulates C-Kit. Blood, 86 (5), 1729-1735. doi: 10.1182/blood.v86.5.1729.bloodjournal8651729

Cytokines Increase Human Hematopoietic-Cell Adhesiveness by Activation of Very Late Antigen (Vla)-4 and Vla-5 Integrins

Levesque, JP, Leavesley, DI, Niutta, S, Vadas, M and Simmons, PJ (1995). Cytokines Increase Human Hematopoietic-Cell Adhesiveness by Activation of Very Late Antigen (Vla)-4 and Vla-5 Integrins. Journal of Experimental Medicine, 181 (5), 1805-1815. doi: 10.1084/jem.181.5.1805

Additive Effects of Steel Factor and Antisense Tgf-Beta-1 Oligodeoxynucleotide On Cd34(+) Hematopoietic Progenitor Cells

Li, ML, Cardoso, AA, Sansilvestri, P, Hatzfeld, A, Brown, EL, Sookdeo, H, Levesque, JP, Clark, SC and Hatzfeld, J (1994). Additive Effects of Steel Factor and Antisense Tgf-Beta-1 Oligodeoxynucleotide On Cd34(+) Hematopoietic Progenitor Cells. Leukemia, 8 (3), 441-445.

Purification and Release From Quiescence of Umbilical-Cord Blood Early Progenitors Reveal Their Potential to Engraft Adults

Hatzfeld, J, Batard, P, Cardoso, AA, Li, ML, Panterne, B, Sansilvestri, P, Ginsbourg, M, Levesque, JP and Hatzfeld, A (1994). Purification and Release From Quiescence of Umbilical-Cord Blood Early Progenitors Reveal Their Potential to Engraft Adults. Blood Cells, 20 (2-3), 430-435.

The Mobilization of Primitive Hematopoietic Progenitors Into the Peripheral-Blood

Simmons, PJ, Leavesley, DI, Levesque, JP, Swart, BW, Haylock, DN, To, LB, Ashman, LK and Juttner, CA (1994). The Mobilization of Primitive Hematopoietic Progenitors Into the Peripheral-Blood. Stem Cells, 12, 187-202.

The Human Hematopoietic Stem-Cell - From Myth to Reality

Hatzfeld, J, Panterne, B, Sansilvestri, P, Batard, P, Levesque, JP, Cardoso, A, Li, ML, Ginsbourg, M, Zhou, YQ and Hatzfeld, A (1993). The Human Hematopoietic Stem-Cell - From Myth to Reality. M S-Medecine Sciences, 9 (10), 1110-1112. doi: 10.4267/10608/2815

Release From Quiescence of Cd34+ Cd38- Human Umbilical-Cord Blood-Cells Reveals Their Potentiality to Engraft Adults

Cardoso, AA, Li, ML, Batard, P, Hatzfeld, A, Brown, EL, Levesque, JP, Sookdeo, H, Panterne, B, Sansilvestri, P, Clark, SC and Hatzfeld, J (1993). Release From Quiescence of Cd34+ Cd38- Human Umbilical-Cord Blood-Cells Reveals Their Potentiality to Engraft Adults. Proceedings of the National Academy of Sciences of the United States of America, 90 (18), 8707-8711. doi: 10.1073/pnas.90.18.8707

Fibrinogen Potentiates the Effect of Interleukin-3 On Early Human Hematopoietic Progenitors

Zhou, YQ, Levesque, JP, Hatzfeld, A, Cardoso, AA, Li, ML, Sansilvestri, P and Hatzfeld, J (1993). Fibrinogen Potentiates the Effect of Interleukin-3 On Early Human Hematopoietic Progenitors. Blood, 82 (3), 800-806. doi: 10.1182/blood.v82.3.800.800

Csf-1 Control of C-Fms Expression in Normal Human Bone-Marrow Progenitors

Panterne, B, Zhou, YQ, Hatzfeld, J, Li, ML, Levesque, JP, Clark, SC and Hatzfeld, A (1993). Csf-1 Control of C-Fms Expression in Normal Human Bone-Marrow Progenitors. Journal of Cellular Physiology, 155 (2), 282-289. doi: 10.1002/jcp.1041550209

Costimulatory Effects of Steel Factor, the C-Kit Ligand, On Purified Human Hematopoietic Progenitors in Low Cell-Density Culture

Li, ML, Cardoso, A, Sansilvestri, P, Hatzfeld, A, Kisselev, S, Batard, P, Levesque, JP and Hatzfeld, J (1993). Costimulatory Effects of Steel Factor, the C-Kit Ligand, On Purified Human Hematopoietic Progenitors in Low Cell-Density Culture. Nouvelle Revue Francaise D Hematologie, 35 (1), 81-86.

Human umbilical cord blood CD34+ cell purification with high yield of early progenitors

Cardoso, Angelo A., Li, Ma-Lin, Batard, Pascal, Sansilvestri, Patricia, Hatzfeld, Antoinette, Levesque, Jean-Pierre, Lebkowski, Jane S. and Hatzfeld, Jacques (1993). Human umbilical cord blood CD34+ cell purification with high yield of early progenitors. Journal of Hematotherapy, 2 (2), 275-279. doi: 10.1089/scd.1.1993.2.275

C-Fos Messenger-Rna Constitutive Expression by Mature Human Megakaryocytes

Panterne, B, Hatzfeld, J, Blanchard, JM, Levesque, JP, Berthier, R, Ginsbourg, M and Hatzfeld, A (1992). C-Fos Messenger-Rna Constitutive Expression by Mature Human Megakaryocytes. Oncogene, 7 (11), 2341-2344.

Cryopreservative Effect of Leupeptin On Early Human Bone-Marrow Progenitors

Li, ML, Panterne, B, Levesque, JP, Hatzfeld, A and Hatzfeld, J (1992). Cryopreservative Effect of Leupeptin On Early Human Bone-Marrow Progenitors. In Vitro Cellular & Developmental Biology-Animal, 28A (6), 459-460. doi: 10.1007/bf02634052

Release of Early Human Hematopoietic Progenitors From Quiescence by Antisense Transforming Growth Factor-Beta-1 or Rb-Oligonucleotides

Hatzfeld, J, Li, ML, Brown, EL, Sookdeo, H, Levesque, JP, Otoole, T, Gurney, C, Clark, SC and Hatzfeld, A (1991). Release of Early Human Hematopoietic Progenitors From Quiescence by Antisense Transforming Growth Factor-Beta-1 or Rb-Oligonucleotides. Journal of Experimental Medicine, 174 (4), 925-929. doi: 10.1084/jem.174.4.925

Dna Transfection in Cos Cells - a Low-Cost Serum-Free Method Compared to Lipofection

Levesque, JP, Sansilvestri, P, Hatzfeld, A and Hatzfeld, J (1991). Dna Transfection in Cos Cells - a Low-Cost Serum-Free Method Compared to Lipofection. Biotechniques, 11 (3), 313-&.

Mitogenic properties of major extracellular proteins

Levesque, JP, Hatzfeld, A and Hatzfeld, J (1991). Mitogenic properties of major extracellular proteins. Immunology Today, 12 (8), 258-262. doi: 10.1016/0167-5699(91)90122-A

A mitogenic fibrinogen receptor that differs from glycoprotein IIb-IIIa: identification by affinity hcromatography and by covalent cross-linking

Levesque, Jean-Pierre, Hatzfeld, Jacques and Hatzfeld, Antoinette (1990). A mitogenic fibrinogen receptor that differs from glycoprotein IIb-IIIa: identification by affinity hcromatography and by covalent cross-linking. Journal of Biological Chemistry, 265 (1), 328-333.

The down-regulation of the mitogenic fibrinogen receptor (MFR) in serum-containing medium does not occur in defined medium

Levesque, JP, Hatzfeld, A, Domart, I and Hatzfeld, J (1990). The down-regulation of the mitogenic fibrinogen receptor (MFR) in serum-containing medium does not occur in defined medium. Experimental Cell Research, 186 (2), 257-263. doi: 10.1016/0014-4827(90)90304-S

Enhanced Activity of Peritoneal-Cells After Aclacinomycin Injection - Effect of Pretreatment with Superoxide-Dismutase On Aclacinomycin-Induced Cytological Alterations and Antitumoral Activity

Bravocuellar, A, Balercia, G, Levesque, JP, Liu, XH, Osculati, F and Orbacharbouys, S (1989). Enhanced Activity of Peritoneal-Cells After Aclacinomycin Injection - Effect of Pretreatment with Superoxide-Dismutase On Aclacinomycin-Induced Cytological Alterations and Antitumoral Activity. Cancer Research, 49 (6), 1578-1586.

Interleukin-3 and Interleukin-1-Alpha Allow Earlier Bone-Marrow Progenitors to Respond to Human Colony-Stimulating Factor-I

Zhou, YQ, Stanley, ER, Clark, SC, Hatzfeld, JA, Levesque, JP, Federici, C, Watt, SM and Hatzfeld, A (1988). Interleukin-3 and Interleukin-1-Alpha Allow Earlier Bone-Marrow Progenitors to Respond to Human Colony-Stimulating Factor-I. Blood, 72 (6), 1870-1874. doi: 10.1182/blood.v72.6.1870.bloodjournal7261870

Binding of C-3 and C3Dg to the Cr-2 Complement Receptor Induces Growth of An Epstein-Barr Virus-Positive Human B-Cell Line

Hatzfeld, A, Fischer, E, Levesque, JP, Perrin, R, Hatzfeld, J and Kazatchkine, MD (1988). Binding of C-3 and C3Dg to the Cr-2 Complement Receptor Induces Growth of An Epstein-Barr Virus-Positive Human B-Cell Line. Journal of Immunology, 140 (1), 170-175.

Evidence for 2 Functionally Different Fibrinogen Receptors On Hematopoietic-Cells - the Glycoprotein Iib-Iiia and the Mitogenic Fibrinogen Receptor

Levesque, JP, Hatzfeld, A, Hudryclergeon, G, Wilner, GD and Hatzfeld, J (1987). Evidence for 2 Functionally Different Fibrinogen Receptors On Hematopoietic-Cells - the Glycoprotein Iib-Iiia and the Mitogenic Fibrinogen Receptor. Journal of Cellular Physiology, 132 (2), 303-310. doi: 10.1002/jcp.1041320215

C-3 Stimulates Proliferation of Human Pre-B Raji Cells

Hatzfeld, J, Charriautmarlangue, C, Levesque, JP, Barel, M, Stancou, R, Krikorian, L, Hatzfeld, A and Frade, R (1987). C-3 Stimulates Proliferation of Human Pre-B Raji Cells. Annales De L Institut Pasteur-Immunology, 138 (3), 451-455. doi: 10.1016/S0769-2625(87)80055-7

Fibrinogen Mitogenic Effect On Hematopoietic-Cell Lines - Control Via Receptor Modulation

Levesque, JP, Hatzfeld, A and Hatzfeld, J (1986). Fibrinogen Mitogenic Effect On Hematopoietic-Cell Lines - Control Via Receptor Modulation. Proceedings of the National Academy of Sciences of the United States of America, 83 (17), 6494-6498. doi: 10.1073/pnas.83.17.6494

A method to measure receptor binding of ligands with low affinity. Application to plasma proteins binding assay with hemopoietic cells

Levesque, JP, Hatzfeld, A and Hatzfeld, J (1985). A method to measure receptor binding of ligands with low affinity. Application to plasma proteins binding assay with hemopoietic cells. Experimental Cell Research, 156 (2), 558-562. doi: 10.1016/0014-4827(85)90563-4

3092 – Stable colony stimulating factor 1 fusion protein treatment increases the hematopoietic stem cell pool and enhances their mobilization in mice

Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy, Millard, Susan, Batoon, Lena, Sandrock, Cheyenne, Levesque, Jean-Pierre, Hume, David, Raggatt, Liza and Pettit, Allison (2020). 3092 – Stable colony stimulating factor 1 fusion protein treatment increases the hematopoietic stem cell pool and enhances their mobilization in mice. 49th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, New York, NY USA, 20-23 August 2020. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.exphem.2020.09.105

Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways

Winkler, Ingrid G., Barbier, Valerie, Tay, Joshua, Levesque, Jean-Pierre, Magnani, John L., Fiveash, Corrine E. and Erbani, Johanna D. (2019). Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways. 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Orlando, FL, United States, 7-10 December 2019. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2019-132212

CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche

Erbani, Johanna D., Tay, Joshua, Barbier, Valerie, Levesque, Jean-Pierre, Magnani, John L. and Winkler, Ingrid G. (2019). CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche. 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Orlando, FL, United States, 7-10 December 2019. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2019-132233

Prostaglandin I-2 in the endosteal bone marrow niche as a novel regulator of hematopoietic stem cells

Tay, Joshua, Levesque, Jean-Pierre, Helwani, Falak, Price, Gareth, Nowlan, Bianca, Barbier, Valerie and Winkler, Ingrid G. (2018). Prostaglandin I-2 in the endosteal bone marrow niche as a novel regulator of hematopoietic stem cells. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA United States, 1-4 December 2018. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2018-99-115869

Self-repopulating recipient bone marrow recipient macrophages promote hematopoietic stem cell engraftment post autologous transplantation

Pettit, Allison, Kaur, Simranpreet, Raggatt, Liza, Millard, Susan, Wu, Andy, Batoon, Lena, Jacobsen, Rebecca, Winkler, Ingrid, MacDonald, Kelli, Perkins, Andrew, Hume, David and Levesque, Jean-Pierre (2018). Self-repopulating recipient bone marrow recipient macrophages promote hematopoietic stem cell engraftment post autologous transplantation. 47th Annual Scientific Meeting of the International Society for Experimental Hematology, Los Angeles, CA, United States, 23-26 August 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2018.06.117

Understanding hematopoietic stem/progenitor cell responses after spinal cord injury

Jung, Won-Cheol, Jogia, Trisha, Gillespie, Ellen, Reid, Chantelle, Levesque, Jean-Pierre and Ruitenberg, Marc (2018). Understanding hematopoietic stem/progenitor cell responses after spinal cord injury. 3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, Toronto, Canada, 11-16 August 2018. New Rochelle, NY, United States: Mary Ann Liebert.

Vascular E-selectin acts as a gatekeeper inducing commitment and loss of self-renewal in HSC transmigrating through the marrow vasculture

Winkler, Ingrid G., Barbier, Valerie, Lowe, Jessica, Tay, Joshua, Magnani, John L., Marlton, Paula, Mills, Anthony K., Perkins, Andrew, Fiveash, Corrine E., Erbani, Johanna M. and Levesque, Jean-Pierre (2018). Vascular E-selectin acts as a gatekeeper inducing commitment and loss of self-renewal in HSC transmigrating through the marrow vasculture. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA United States, 1-4 December 2018. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2018-99-120376

Macrophage involvement in the response of acute myeloid leukaemia to chemotherapy

Keech, Thomas, McGirr, Crystal, Winkler, Ingrid G. and Levesque, Jean-Pierre (2017). Macrophage involvement in the response of acute myeloid leukaemia to chemotherapy. 59th Annual Meeting of the American Society of Hematology (ASH), Atlanta, GA USA, 9-12 December 2017. Washington, DC USA: American Society of Hematology.

Vascular E-Selectin Mediates Chemo-Resistance in Acute Myeloid Leukemia Initiating Cells Via Canonical Receptors PSGL-1 (CD162) and Hcell (CD44) and AKT Signaling

Winkler, Ingrid G., Erbani, Johanna M., Barbier, Valerie, Davies, Julie M., Tay, Joshua, Fiveash, Corrine E., Lowe, Jessica, Tallack, Michael, Magnani, John L. and Levesque, Jean-Pierre (2017). Vascular E-Selectin Mediates Chemo-Resistance in Acute Myeloid Leukemia Initiating Cells Via Canonical Receptors PSGL-1 (CD162) and Hcell (CD44) and AKT Signaling. 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA, United States, 9-12 December 2017. Washington, DC, United States: American Society of Hematology.

Therapeutic Blockade of Macrophage Colony Stimulating Factor (CSF-1) Delays AML Progression in Mice In Vivo

Goh, Sal Lee, Levesque, Jean-Pierre, Petitt, Allison R., Barbier, Valarie and Winkler, Ingrid G. (2016). Therapeutic Blockade of Macrophage Colony Stimulating Factor (CSF-1) Delays AML Progression in Mice In Vivo. 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego Ca, Dec 03-06, 2016. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V128.22.2835.2835

Prostaglandin I2 is produced in the endosteal region of the bone marrow and protects haematopoietic stem cell from irradiation stress

Tay, Joshua, Levesque, Jean-Pierre, Helwani, Falak, Price, Gareth, Barbier, Valerie, Nowlan, Bianca and Winkler, Ingrid (2016). Prostaglandin I2 is produced in the endosteal region of the bone marrow and protects haematopoietic stem cell from irradiation stress. 45th Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), San Diego, CA, United States, 25-28 August 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.224

Therapeutic blockade of macrophage colony stimulating factor (CSF-1) delays leukaemia progression of AMLin mice in vivo

Goh, Sal Lee, Levesque, Jean-Pierre, Pettit, Allison, Barbier, Valerie, Jeanclos, Cecile and Winkler, Ingrid (2016). Therapeutic blockade of macrophage colony stimulating factor (CSF-1) delays leukaemia progression of AMLin mice in vivo. 45th Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), San Diego, CA, United States, 25-28 August 2016. Philadelphia, PA, United States: Elsevier.

Hematopoietic Stem Cell Mobilization and Erythropoiesis Suppression in Response to Lipopolysaccharides Involve Two Distinct Tlr4-Depedent Mechanisms with Different Requirement for G-Csf Receptors

Bisht, Kavita, Jacobsen, Rebecca, Brunck, Marion, Keech, Thomas, McGirr, Crystal, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid and Levesque, Jean-Pierre (2016). Hematopoietic Stem Cell Mobilization and Erythropoiesis Suppression in Response to Lipopolysaccharides Involve Two Distinct Tlr4-Depedent Mechanisms with Different Requirement for G-Csf Receptors. 45th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), San Diego, CA, United States, 25-28 August 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.096

Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation

Levesque, Jean-Pierre, Kaur, Simranpreet, Jacobsen, Rebecca, Millard, Susan, Batoon, Lena, Winkler, Ingrid, Macdonald, Kelli, Perkins, Andrew, Hume, David, Raggatt, Liza and Pettit, Allison (2016). Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation. 45th Annual Scientific Meeting of the ISEH – International Society for Experimental Hematology, San Diego, CA, United States, 25-28 August, 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.049

Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation

Kaur, S., Raggatt, L. J., Jacobsen, R. N., Millard, S., Batoon, L., Winkler, I. G., Macdonald, K. P. A., Perkins, A. C., Hume, D. A., Levesque, J. P. and Pettit, A. R. (2016). Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

Suppression of medullar erythropoiesis in response to bacterial lipopolysaccharides (LPS) involves two distinct TLR4-dependent mechanisms with contrasted requirements for G-CSF receptors

Bisht, Kavita, Jacobsen, Rebecca, Nowlan, Bianca, McGirr, Crystal, Brunck, Marion, Keech, Thomas, Winkler, Ingrid G. and Levesque, Jean-Pierre (2016). Suppression of medullar erythropoiesis in response to bacterial lipopolysaccharides (LPS) involves two distinct TLR4-dependent mechanisms with contrasted requirements for G-CSF receptors. 58th Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego, CA, United States, 3-6 December 2016. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V128.22.546.546

Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation

Winkler, Ingrid G., Barbier, Valerie, Ward, Micheal, Tallack, Michael, Lowe, Jessica, Davies, Julie, Erbani, Johanna, Magnani, John L. and Levesque, Jean-Pierre (2016). Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation. 58th Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego, CA, United States, 3-6 December 2016. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.v128.22.2823.2823

Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages

Kaur, Simranpreet, Raggatt, Liza J., Jacobsen, Rebecca, Millard, Susan, Barbier, Valerie, Nowlan, Bianca, Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean P. and Pettit, Allison R. (2015). Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages. 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto, Japan, 17-19 September 2015. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2015.06.157

Mobilization of CD8(+) Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade

Winkler, Ingrid G., Barbier, Valerie, Radford, Kristen J., Davies, Julie M., Levesque, Jean-Pierre, Smith, Theodore A. G., Fogler, William E. and Magnani, John L. (2015). Mobilization of CD8(+) Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade. 57th Annual Meeting of the American Society of Hematology, Orlando, FL United States, 5-8 December 2015. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V126.23.512.512

Bacterial liposaccharides block medullary erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+LY-6G+ Erythroid island macrophages in the bone marrow

Jacobsen, Rebecca, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid and Levesque, Jean-Pierre (2014). Bacterial liposaccharides block medullary erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+LY-6G+ Erythroid island macrophages in the bone marrow. 43rd Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), Montreal, Canada, 21-24 August 2014. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2014.07.147

Mobilisation of Reconstituting HSC Is Boosted By Synergy Between G-CSF and E-Selectin Antagonist GMI-1271

Winkler, Ingrid G., Barbier, Valerie, Perkins, Andrew C., Magnani, John L. and Levesque, Jean-Pierre (2014). Mobilisation of Reconstituting HSC Is Boosted By Synergy Between G-CSF and E-Selectin Antagonist GMI-1271. 56th Annual Meeting of the American Society of Hematology, San Francisco, CA United States, 6-9 December 2014. Washington, DC United States: American Society of Hematology.

Vascular Niche E-Selectin Protects Acute Myeloid Leukaemia Stem Cells from Chemotherapy

Winkler, Ingrid G., Barbier, Valerie, Pattabiraman, Diwakar R., Gonda, Thomas J., Magnani, John L. and Levesque, Jean-Pierre (2014). Vascular Niche E-Selectin Protects Acute Myeloid Leukaemia Stem Cells from Chemotherapy. 56th Annual Meeting of the American Society of Hematology, San Francisco CA, United States, 6-9 December 2014. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V124.21.620.620

Hypoxia Inducible Factor (HIF)-2 alpha Enhances Proliferation Of Malignant Hematopoietic Cells In The Hypoxic Malignant Bone Marrow

Forristal, Catherine E., Helwani, Falak, Martin, Sally, Nowlan, Bianca, Winkler, Ingrid G., Zannettino, Andrew and Levesque, Jean-Pierre (2013). Hypoxia Inducible Factor (HIF)-2 alpha Enhances Proliferation Of Malignant Hematopoietic Cells In The Hypoxic Malignant Bone Marrow. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, United States, 7-10 December 2013. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V122.21.2895.2895

Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery

Winkler, Ingrid G., Barbier, Valerie, Nutt, Heather L., Hasnain, Sumaira Z., Levesque, Jean-Pierre, Magnani, John L. and McGuckin, Michael A. (2013). Administration Of E-Selectin Antagonist GMI-1271 Improves Survival After High-Dose Chemotherapy By Alleviating Mucositis and Accelerating Neutrophil Recovery. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans La, Dec 07-10, 2013. WASHINGTON: AMER SOC HEMATOLOGY.

Pharmacological stabilization of hypoxia-inducible factor-1α (HIF-1α) enhances hematopoietic stem cell mobilization in response to G-CSF and plerixafor

Forristal, Catherine, Nowlan, B., Barbier, Valerie, Winkler, Ingrid, Walkinshaw, Gail and Levesque, Jean-Pierre (2013). Pharmacological stabilization of hypoxia-inducible factor-1α (HIF-1α) enhances hematopoietic stem cell mobilization in response to G-CSF and plerixafor. 42nd Annual Scientific Meeting of the International Society for Experimental Hematology and Stem Cells (ISEH), Vienna, Austria, 22-25 August 2013. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2013.05.284

Mobilising Doses of G-Csf Stop Medullary Erythropoiesis by Depleting Cd169+Macrophages

Jacobsen, Rebecca, Pettit, Allison, Barbier, Valerie, Nowlan, Bianca, Raggatt, Liza, Winkler, Ingrid and Levesque, Jean-Pierre (2013). Mobilising Doses of G-Csf Stop Medullary Erythropoiesis by Depleting Cd169+Macrophages. 42nd Annual Scientific Meeting of ISEH - Society for Hematology and Stem Cells, Vienna, Austria, 22-25 August 2013. Philadelphia, PA United States: Elsevier Inc. doi: 10.1016/j.exphem.2013.05.230

Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/8o+VCAM1+ER-HR3+CD169+Erythroid-Island Macrophages

Jacobsen, Rebecca, Pettit, Allison R., Raggatt, Liza J., Nowlan, Bianca, Barbier, Valerie, Forristal, Catherine E., Winkler, Ingrid G. and Levesque, Jean-Pierre (2013). Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/8o+VCAM1+ER-HR3+CD169+Erythroid-Island Macrophages. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, United States, 7-10 December 2013. WASHINGTON: AMER SOC HEMATOLOGY.

FG-4497, a Pharmacological Stabilizer of HIF-1 alpha Protein, Synergistically Enhances Hematopoietic Stem Cells (HSC) Mobilization in Response to G-CSF and Plerixafor

Forristal, Catherine E., Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid G., Walkinshaw, Gail and Levesque, Jean-Pierre (2012). FG-4497, a Pharmacological Stabilizer of HIF-1 alpha Protein, Synergistically Enhances Hematopoietic Stem Cells (HSC) Mobilization in Response to G-CSF and Plerixafor. 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, United States, 8-11 December 2012. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V120.21.216.216

Hypoxia and E-selectin are opposite regulators of hematopoietic stem cell quiescence in the niche

Levesque, Jean-Pierre, Forristal, Catherine and Winkler, Ingrid (2012). Hypoxia and E-selectin are opposite regulators of hematopoietic stem cell quiescence in the niche. 41st Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Amsterdam Netherlands, 23-26 August 2012. Philadelphia, PA United States: Elsevier.

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia by human AML oncogenes, and represents a potential therapeutic target

Pattabiraman, Diwakar R., Shakhbazov, Konstantin, Barbier, Valerie, McGirr, Crystal, Krishnan, Keerthana, Mukhopadhyay, Pamela, Hawthorne, Paula, Trezise, Ann, Grimmond, Sean, Papathanasiou, Peter, Perkins, Andrew C., Levesque, Jean-Pierre, Alexander, Warren S., Winkler, Ingrid G. and Gonda, Thomas J. (2012). Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia by human AML oncogenes, and represents a potential therapeutic target. 54th Annual Meeting and Exposition of the American Society of Hematology (ASH), Atlanta, GA, United States, 8-11 Deceember, 2012. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V120.21.2402.2402

Impairment of Hematopoietic Stem Cell (HSC) Niche by G-CSF Is Associated with Rapid Mobilization of Serially Reconstituting HSC and Reduced Competitive Repopulation of Mobilized Bone Marrow

Levesque, Jean-Pierre, Barbier, Valerie, Nowlan, Bianca, McCarhty, Domenica and Winkler, Ingrid G. (2011). Impairment of Hematopoietic Stem Cell (HSC) Niche by G-CSF Is Associated with Rapid Mobilization of Serially Reconstituting HSC and Reduced Competitive Repopulation of Mobilized Bone Marrow. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology.

Oxygen-Independent Stabilization of the Oxygen-Labile Transcription Factor HIF-1 alpha with Dimethyloxalyl Glycine or FG-4497 Increases Hematopoietic Stem Cell Quiescence In Vivo and Mobilization in Response to G-CSF

Forristal, Catherine, Nowlan, Bianca, Barbier, Valerie, McCarthy, Domenica, Walkinshaw, Gail, Winkler, Ingrid G. and Levesque, Jean-Pierre (2011). Oxygen-Independent Stabilization of the Oxygen-Labile Transcription Factor HIF-1 alpha with Dimethyloxalyl Glycine or FG-4497 Increases Hematopoietic Stem Cell Quiescence In Vivo and Mobilization in Response to G-CSF. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology.

Mobilizing agents G-CSF, cyclophosphamide or AMD3100 (Plerixafor) Have distinct effects on osteoblasts, hematopoietic stem cell niches, and B-Lymphopoiesis

Levesque, Jean-Pierre, Bendall, Linda J., Pettit, Allison R., Raggatt, Liza, Jacobsen, Rebecca, Barbier, Valarie, Nowlan, Bianca, Shen, Yi Shen, Sims, Natalie A. and Winkler, Ingrid G. (2011). Mobilizing agents G-CSF, cyclophosphamide or AMD3100 (Plerixafor) Have distinct effects on osteoblasts, hematopoietic stem cell niches, and B-Lymphopoiesis. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology.

A molecular profile of the hematopoietic stem cell niche at the endosteum

Helwani, F., Winkler, I., Price, G. and Levesque, J. P. (2010). A molecular profile of the hematopoietic stem cell niche at the endosteum. 39th Annual Scientific Meeting of the ISEH - Society for Hematology and Stem Cells, Melbourne, VIC, Australia, 15-18 September 2010. Philadelphia, PA, United States: Elsevier.

The role of tissue inhibitor of metalloproteinase-3 (TIMP-3) in hematopoiesis

Shen, Y., Barbier, V., Winkler, I., Sims, N., Hendy, J. and Levesque, J. P. (2010). The role of tissue inhibitor of metalloproteinase-3 (TIMP-3) in hematopoiesis. 39th Annual Scientific Meeting of the ISEH - Society for Hematology and Stem Cells, Melbourne, VIC, Australia, 15-18 September 2010. Philadelphia, PA, United States: Elsevier.

DEPLETION OF BONE MARROW PHAGOCYTES CAUSES THE MOBILIZATION OF LONG-TERM RECONSTITUTING HEMATOPOIETIC STEM CELLS

Jacobsen, RN, Levesque, JP, Barbier, V, Raggatt, LJ and Pettit, AR (2010). DEPLETION OF BONE MARROW PHAGOCYTES CAUSES THE MOBILIZATION OF LONG-TERM RECONSTITUTING HEMATOPOIETIC STEM CELLS. 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne AUSTRALIA, SEP 15-18, 2010. NEW YORK: ELSEVIER SCIENCE INC.

Absence or Blockage of E-Selectin-Mediated Cell Adhesion Delays Hematopoietic Stem Cell (HSC) Turn-Over and Enhances Chemoresistance

Winkler, Ingrid G., Barbier, Valerie, Nowlan, Bianca, Smith, Theodore, Patton, John T., Magnani, John L. and Levesque, Jean-Pierre (2009). Absence or Blockage of E-Selectin-Mediated Cell Adhesion Delays Hematopoietic Stem Cell (HSC) Turn-Over and Enhances Chemoresistance. 51st Annual Meeting of the American Society of Hematology, New Orleans, LA, United States, 5-8 December 2009. Washington, DC, United States: American Society of Hematology.

Absence of e-selectin delays hematopoietic stem cell (HSC) turnover and enhances chemoresistance

Winkler, I. G., Levesque, J. P., Barbier, V. and Nowlan, B. (2009). Absence of e-selectin delays hematopoietic stem cell (HSC) turnover and enhances chemoresistance. 38th Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Athens, Greece, 9-12 September 2009. Philadelphia, PA, United States: Elsevier.

Positioning of mouse bone marrow hematopoietic stem and progenitor cells and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells (HSC) reside in niches that are poorly perfused by circulating blood

Levesque, J. P., Barbier, V., Wadley, R. and Winkler, I. G. (2009). Positioning of mouse bone marrow hematopoietic stem and progenitor cells and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells (HSC) reside in niches that are poorly perfused by circulating blood. 38th Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Athens, Greece, 9-12 September 2009. Philadelphia, PA, United States: Elsevier.

Endosteal Macrophages Maintain the Hematopoietic Stem Cell (Hsc) Niche and Participate in Hsc Mobilization Induced by G-Csf or Chemotherapy

Levesque, J. P., Raggatt, L. J., Pettit, A. R., Sims, N. A., Bendall, L. J. and Helwani, F. (2009). Endosteal Macrophages Maintain the Hematopoietic Stem Cell (Hsc) Niche and Participate in Hsc Mobilization Induced by G-Csf or Chemotherapy. 38th Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Athens, Greece, 9-12 September 2009. NEW YORK: ELSEVIER SCIENCE INC.

Osteomacs maintain the endosteal hematopoietic stem cell niche and participate in mobilization

Pettit, A. R., Sims, N. A., Winkler, I. G., Alexander, K. A., Helwani, F., Raggatt, L. J. and Levesque, J. P. (2009). Osteomacs maintain the endosteal hematopoietic stem cell niche and participate in mobilization. 2nd Joint Meeting of the International Bone and Mineral Society/Australian New Zealand Bone and Mineral Society, Sydney, Australia, 21-25 March, 2009. United States: Elsevier Inc.. doi: 10.1016/j.bone.2009.01.082

Endosteal Niches and Lymphopoiesis Are Inhibited during G-CSF-Induced Hematopoietic Stem Cell Mobilization

Levesque, Jean-Pierre, Sims, Natalie A., Bendall, Linda J., Shen, Yi and Winkler, Ingrid G. (2008). Endosteal Niches and Lymphopoiesis Are Inhibited during G-CSF-Induced Hematopoietic Stem Cell Mobilization. 50th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, United States, 6-9 December 2008. Washington, DC, United States: American Society of Hematology.

The Role of Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) in Hematopoiesis

Shen, Yi, Barbier, Valerie, Winkler, Ingrid G., Hendy, Jean and Levesque, Jean-Pierre (2008). The Role of Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) in Hematopoiesis. 50th Annual Meeting of the American-Society-of-Hematology, San Francisco, CA, United States, 6-9 December 2008. Washington, DC, United States: American Society of Hematology.

Absence of E-selectin at the vascular niche delays hematopoietic stem cell turn-over

Winkler, Ingrid G., Nowlan, Bianca, Barbier, Valerie and Levesque, Jean-Pierre (2007). Absence of E-selectin at the vascular niche delays hematopoietic stem cell turn-over. 49th Annual Meeting of the American-Society-of-Hematology, Atlanta, GA, United States, 8-11 December 2007. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V110.11.609.609

Increased hypoxia, HIF-1 alpha protein and VEGF transcripts in bone marrow mobilized with G-CSF or cyclophosphamide (CY)

Levesque, Jean-Pierre, Winkler, Ingrid G., Hendy, Jean and Nilsson, Susan K. (2006). Increased hypoxia, HIF-1 alpha protein and VEGF transcripts in bone marrow mobilized with G-CSF or cyclophosphamide (CY). 48th Annual Meeting of the American Society of Hematology, Orlando, FL United States, 9-12 December 2006. Washington, DC United States: American Society of Hematology.

G-CSF potently suppresses osteoblast activity in the bone marrow

Christopher, M. J., Liu, F., Short, B., Simmons, P. J., Winkler, I., Levesque, J. P. and Link, D. C. (2005). G-CSF potently suppresses osteoblast activity in the bone marrow. 47th Annual Meeting of the American-Society-of-Hematology, Atlanta, GA, United States, 10-13 December 2005. Washington, DC, United States: American Society of Hematology.

Protease-dependent and protease-independent mechanisms of hematopoietic progenitor cell (HPC) mobilization

Levesque, JP, Liu, F, Winkler, IG, Simmons, PJ, Betsuyaku, T, Senior, R, Pham, C and Link, DC (2004). Protease-dependent and protease-independent mechanisms of hematopoietic progenitor cell (HPC) mobilization. 33rd Annual Meeting of the International Society for Experimental Hematology, New Orleans, LA, United States, 17-20 July 2004. Philadelphia, PA, United States: Elsevier.

P-selectin delays the in vitro differentiation of murine lin- Sca-1+c-KIT+ cells whereas E-selectin accelerates their differentiation

Eto, T, Winkler, , Purton, L, Simmons, P and Levesque, JP (2003). P-selectin delays the in vitro differentiation of murine lin- Sca-1+c-KIT+ cells whereas E-selectin accelerates their differentiation. 32nd Annual Scientific Meeting of the International Society for Experimental Hematology, Paris, France, 5-8 July 2003. Philadelphia, PA, United States: Elsevier.

Proteases that cleave c-KIT receptor (CD117) from the surface of hemopoietic progenitor cells are released in the bone marrow during G-CSF-induced mobilization

Levesque, J. P., Hendy, J., Winkler, I. G., Takamatsu, Y. and Simmons, P. J. (2002). Proteases that cleave c-KIT receptor (CD117) from the surface of hemopoietic progenitor cells are released in the bone marrow during G-CSF-induced mobilization. 44th Annual Meeting of the American-Society-of-Hematology, Philadelphia, PA, United States, 6-10 December 2002. Washington, DC, United States: American Society of Hematology.

Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells

Winkler, IG, Eto, T, Purton, LE, Haylock, DN, Snapp, KR, Kansas, GS, Simmons, PJ and Levesque, JP (2001). Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells. Unknown, Unknown, Unknown. Washington, DC United States: American Society of Hematology.

VCAM-1 cleavage and release of neutrophil serine proteases elastase and cathepsin G in the bone marrow are common features of hemopoietic progenitor cell mobilization induced by G-CSF or chemotherapy

Levesque, J. P., Hendy, J., Takamatsu, Y., Williams, B., Winkler, I. G. and Simmons, P. J. (2001). VCAM-1 cleavage and release of neutrophil serine proteases elastase and cathepsin G in the bone marrow are common features of hemopoietic progenitor cell mobilization induced by G-CSF or chemotherapy. *, *, *. Washington, DC, United States: American Society of Hematology.

Mucin-like molecules as modulators of the survival and proliferation of primitive hematopoietic cells

Simmons, P. J., Levesque, J. P., Haylock, D. N., Eaves, C. J. and Bühring, H. J. (2001). Mucin-like molecules as modulators of the survival and proliferation of primitive hematopoietic cells. Hematopoietic Stem Cells 2000: Basic and Clinical Sciences: Third International Conference, Unknown, June 2001. Malden, MA United States: New York Academy of Sciences. doi: 10.1111/j.1749-6632.2001.tb03590.x

Mobilization of hemopoietic progenitor cells into peripheral blood is associated with VCAM-1 proteolytic cleavage in the-bone marrow.

Levesque, JP, Takamatsu, Y, Nilsson, SK, Haylock, DN and Simmons, PJ (2000). Mobilization of hemopoietic progenitor cells into peripheral blood is associated with VCAM-1 proteolytic cleavage in the-bone marrow.. WASHINGTON: AMER SOC HEMATOLOGY.

Purification and release from quiescence of umbilical cord blood early progenitors reveal their potential to engraft adults

Hatzfeld, J., Batard, P., Cardoso, A. A., Li, M. L., Panterne, B., Sansilvestri, P., Ginsbourg, M., Levesque, J. P. and Hatzfeld, A. (1994). Purification and release from quiescence of umbilical cord blood early progenitors reveal their potential to engraft adults. Unknown, Unknown, Unknown. Maryland Heights, MO, United States: Academic Press.

The mobilization of primitive hemopoietic progenitors into the peripheral blood

Simmons, P. J., Leavesley, D. I., Levesque, J. P., Swart, B. W., Haylock, D. N., To, L. B., Ashman, L. K. and Juttner, C. A. (1994). The mobilization of primitive hemopoietic progenitors into the peripheral blood. Unknown, Unknown, Unknown. Oxford, United Kingdom: Oxford University Press.

Antisense Oligonucleotides for Inhibitors and Tumor-Suppressor Genes Reveal the Hematopoietic Potential of Quiescent Progenitors

Hatzfeld, J, Li, ML, Cardoso, A, Batard, P, Levesque, JP, Brown, E, Sookdeo, H, Clark, SC and Hatzfeld, A (1993). Antisense Oligonucleotides for Inhibitors and Tumor-Suppressor Genes Reveal the Hematopoietic Potential of Quiescent Progenitors. 3rd International Conference on Negative Regulation of Hematopoiesis, Paris France, Apr 18-22, 1993. PARIS: EDITIONS INSERM.

Co-stimulatory effects of steel factor, the c-kit ligand, on purified human hematopoietic progenitors in low cell density culture

Li, M. L., Cardoso, A., Sansilvestri, P., Hatzfeld, A., Kisselev, S., Batard, P., Levesque, J. P. and Hatzfeld, J. (1993). Co-stimulatory effects of steel factor, the c-kit ligand, on purified human hematopoietic progenitors in low cell density culture. Unknown, Unknown, Unknown. Paris, France: Springer.

Positive and negative controls of hematopoietic progenitor development models and experimental findings

Panterne, B., Hatzfeld, A., Zhou, Y. Q., Li, M. L., Sansilvestri, P., Cardoso, A., Levesque, J. P., Ginsbourg, M., Batard, P., Kiselev, S. and Hatzfeld, J. (1993). Positive and negative controls of hematopoietic progenitor development models and experimental findings. Unknown, Unknown, Unknown. Paris, France: Springer.

Autocrine Transforming Growth-Factor-Beta Controls G0 Phase of Early Human Hematopoietic Progenitors in Serum-Free or Serum-Free Culture

Li, ML, Hatzfeld, A, Brown, EL, Sookdeo, H, Panterne, B, Levesque, JP, Otoole, T, Clark, SC and Hatzfeld, J (1991). Autocrine Transforming Growth-Factor-Beta Controls G0 Phase of Early Human Hematopoietic Progenitors in Serum-Free or Serum-Free Culture. Beijing Symp On Blood Cell Growth Factors : Their Present and Future Use in Hematology and Oncology, Beijing Peoples R China, Aug 21-24, 1991. DAYTON: ALPHAMED PRESS.