Dr Mitchell Stark

UQ Amplify Researcher

The University of Queensland Diamantina Institute
Faculty of Medicine

Affiliate Academic

Institute for Molecular Bioscience
m.stark@uq.edu.au
+61 7 344 38027

Overview

Dr Mitchell Stark is a molecular biologist and Group Leader/Senior Research Fellow from the Dermatology Research Centre (DRC), The University of Queensland Diamantina Institute (UQDI). His group has extensive experience in microRNA biology and biomarker discovery, next-generation sequencing, bioinformatics, and functional analysis for a variety of applications. The Stark Lab’s major research streams include: miRNA biomarkers for melanoma progression and the development a Genomics Atlas of pre-skin cancer lesions, which aim to provide insight into the early progression of melanoma and keratinocyte cancer, to aid in preventing invasive skin cancer formation and offer increased precision to the clinical management of patients.

Dr Stark completed his PhD (2015) in melanoma microRNA biomarkers at The Queensland University of Technology based at the QIMR Berghofer (QIMRB) Medical Research Institute. Prior to commencing his PhD, he worked as Senior Research Assistant (since 1999) and was trained and mentored in the Hayward lab (QIMRB) where he contributed to and led some seminal findings in the melanoma genetics/genomics field. Dr Stark joined the DRC (UQDI) in 2015 and in 2016 he was awarded a prestigious NHMRC Peter Doherty Early Career Fellowship (2016-2019) to lead a pre-melanoma genomics program. Currently he is a UQ Amplify Research Fellow (2020-2021). Dr Stark has a career total of 71 publications (h-index 35) including 1 patent and has published in respected journals such as Nature, Nature Genetics, Cancer Research, and Journal of Investigative Dermatology.

Research Interests

  • MicroRNA Biomarkers
    Current projects relate to melanoma progression microRNA biomarkers to aid in increased diagnostic precision of “ambiguous” melanocytic lesions as well as “real-time” monitoring of melanoma disease progression using a “liquid biopsy.”
  • Genomics Atlas of pre-skin cancer lesions
    Current projects involve using overlapping genomics datasets (e.g. exome, mRNA and miRNA transcriptome, methylation) as well as Spatial Profiling to greater understand the early hallmarks of pre-skin cancer development.

Qualifications

  • Doctor of Philosophy, Queensland University of Technology
  • Bachelor of Applied Science (Life Science), Queensland University of Technology

Publications

  • Stark, Mitchell S., Tell-Martí, Gemma, Martins da Silva, Vanessa, Martinez-Barrios, Estefania, Calbet-Llopart, Neus, Vicente, Asunción, Sturm, Richard A., Soyer, H. Peter, Puig, Susana, Malvehy, Josep, Carrera, Cristina and Puig-Butillé, Joan A. (2021). The distinctive genomic landscape of giant congenital melanocytic nevi. Journal of Investigative Dermatology, 141 (3), 692-695. doi: 10.1016/j.jid.2020.07.022

  • Lee, Katie J., Janda, Monika, Stark, Mitchell S, Sturm, Richard A. and Soyer, H. Peter (2021). On naevi and melanomas: two sides of the same coin?. Frontiers in Medicine, 8 635316, 635316. doi: 10.3389/fmed.2021.635316

  • Stark, Mitchell S., Tan, Jean-Marie, Tom, Lisa, Jagirdar, Kasturee, Lambie, Duncan, Schaider, Helmut, Soyer, H. Peter and Sturm, Richard A. (2018). Whole-exome sequencing of acquired nevi identifies mechanisms for development and maintenance of benign neoplasms. Journal of Investigative Dermatology, 138 (7), 1636-1644. doi: 10.1016/j.jid.2018.02.012

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Available Projects

  • Australian domestic or on-shore International student applicants only. The Stark Lab is seeking talented and highly motivated PhD student(s) to join their team at The Dermatology Research Centre, The University of Queensland Diamantina Institute. Various projects are available relating to 2 major research streams: microRNA biomarkers for melanoma progression and the development a Genomics Atlas of pre-skin cancer lesions.If you are interested to hear more about the projects which harness the latest cutting edge technologies (e.g. spatial profiling), then please send your current CV, Academic Transcript, and Cover Letter to m.stark@uq.edu.au Living stipend scholarships and Tuition Scholarships are available for application from the UQ Graduate School which are currently a Base Stipend of $28,597 per annum tax free (2021 rate), indexed annually, Overseas Student Health Cover (OSHC). Top-up Scholarships (tax-free) may also be available. Applications for scholarships close 28th March for commencement in July 2021.

View all Available Projects

Publications

Featured Publications

Book Chapter

Journal Article

  • Stark, Mitchell S., Tell-Martí, Gemma, Martins da Silva, Vanessa, Martinez-Barrios, Estefania, Calbet-Llopart, Neus, Vicente, Asunción, Sturm, Richard A., Soyer, H. Peter, Puig, Susana, Malvehy, Josep, Carrera, Cristina and Puig-Butillé, Joan A. (2021). The distinctive genomic landscape of giant congenital melanocytic nevi. Journal of Investigative Dermatology, 141 (3), 692-695. doi: 10.1016/j.jid.2020.07.022

  • Lee, Katie J., Janda, Monika, Stark, Mitchell S, Sturm, Richard A. and Soyer, H. Peter (2021). On naevi and melanomas: two sides of the same coin?. Frontiers in Medicine, 8 635316, 635316. doi: 10.3389/fmed.2021.635316

  • Emmett, S.E., Stark, M.S., Pandeya, N., Panizza, B., Whiteman, D.C. and Antonsson, A. (2021). MicroRNA expression is associated with human papillomavirus status and prognosis in mucosal head and neck squamous cell carcinomas. Oral Oncology, 113 105136, 105136. doi: 10.1016/j.oraloncology.2020.105136

  • McMeniman, E. K., McInerney-Leo, A. M., Peach, E., Lee, K. J., Yanes, T., Jagirdar, K., Stark, M. S., Soyer, H. P., Duffy, D. L. and Sturm, R. A. (2020). CDKN2A testing threshold in a high-risk Australian melanoma cohort: number of primaries, family history and young age of onset impact risk. Journal of the European Academy of Dermatology and Venereology, 34 (12) jdv.16627, e797-e798. doi: 10.1111/jdv.16627

  • Stark, Mitchell S., Denisova, Evgeniya, Kays, Trent A., Heidenreich, Barbara, Rachakonda, Sivaramakrishna, Requena, Celia, Sturm, Richard A., Soyer, H. Peter, Nagore, Eduardo and Kumar, Rajiv (2020). Mutation signatures in melanocytic nevi reveal characteristics of defective DNA repair. Journal of Investigative Dermatology, 140 (10), 2093-2096.e2. doi: 10.1016/j.jid.2020.02.021

  • Rayner, Jenna E., Duffy, David L., Smit, Darren J., Jagirdar, Kasturee, Lee, Katie J., De’Ambrosis, Brian, Smithers, B. Mark, McMeniman, Erin K., McInerney-Leo, Aideen M., Schaider, Helmut, Stark, Mitchell S., Soyer, H. Peter and Sturm, Richard A. (2020). Germline and somatic albinism variants in amelanotic/hypomelanotic melanoma: increased carriage of TYR and OCA2 variants. PLoS ONE, 15 (9) e0238529, e0238529. doi: 10.1371/journal.pone.0238529

  • Grossman, Douglas, Okwundu, Nwanneka, Bartlett, Edmund K., Marchetti, Michael A., Othus, Megan, Coit, Daniel G., Hartman, Rebecca I., Leachman, Sancy A., Berry, Elizabeth G., Korde, Larissa, Lee, Sandra J., Bar-Eli, Menashe, Berwick, Marianne, Bowles, Tawnya, Buchbinder, Elizabeth I., Burton, Elizabeth M., Chu, Emily Y., Curiel-Lewandrowski, Clara, Curtis, Julia A., Daud, Adil, Deacon, Dekker C., Ferris, Laura K., Gershenwald, Jeffrey E., Grossmann, Kenneth F., Hu-Lieskovan, Siwen, Hyngstrom, John, Jeter, Joanne M., Judson-Torres, Robert L., Kendra, Kari L. ... Swetter, Susan M. (2020). Prognostic Gene Expression Profiling in Cutaneous Melanoma : Identifying the Knowledge Gaps and Assessing the Clinical Benefit. JAMA Dermatology, 156 (9), e1-e8. doi: 10.1001/jamadermatol.2020.1729

  • Roy, Edwige, Wong, Ho Yi, Villani, Rehan, Rouille, Thomas, Salik, Basit, Sim, Seen Ling, Murigneux, Valentine, Stark, Mitchell S., Fink, J. Lynn, Soyer, H. Peter, Walker, Graeme, Lyons, J. Guy, Saunders, Nicholas and Khosrotehrani, Kiarash (2020). Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors. Cell Reports, 31 (9) 107702, 107702. doi: 10.1016/j.celrep.2020.107702

  • Pavey, Sandra, Pinder, Alex, Fernando, Winnie, D'Arcy, Nicholas, Matigian, Nicholas, Skalamera, Dubravka, Lê Cao, Kim-Anh, Loo-Oey, Dorothy, Hill, Michelle M., Stark, Mitchell, Kimlin, Michael, Burgess, Andrew, Cloonan, Nicole, Sturm, Richard A. and Gabrielli, Brian (2019). Multiple interaction nodes define the post-replication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load. Molecular Oncology, 14 (1) 1878-0261.12601, 22-41. doi: 10.1002/1878-0261.12601

  • Stark, Mitchell S., Gray, Elin S., Isaacs, Timothy, Chen, Fred K., Millward, Michael, McEvoy, Ashleigh, Zaenker, Pauline, Ziman, Melanie, Soyer, H. Peter, Glasson, William J., Warrier, Sunil K., Stark, Andrew L., Rolfe, Olivia J., Palmer, Jane M. and Hayward, Nicholas K. (2019). A panel of circulating microRNAs detects uveal melanoma with high precision. Translational Vision Science and Technology, 8 (6) 12, 12. doi: 10.1167/tvst.8.6.12

  • Duffy, D. L., Lee, K. J., Jagirdar, K., Pflugfelder, A., Stark, M. S., McMeniman, E. K., Soyer, H. P. and Sturm, R. A. (2019). Naevus count and MC1R R alleles contribute to melanoma risk. British Journal of Dermatology, 181 (5), e119-e119. doi: 10.1111/bjd.18487

  • Stark, Mitchell S. (2019). Large-giant congenital melanocytic nevi: moving beyond NRAS mutations. Journal of Investigative Dermatology, 139 (4), 756-759. doi: 10.1016/j.jid.2018.10.003

  • Duffy, D. L., Lee, K. J., Jagirdar, K., Pflugfelder, A., Stark, M. S., McMeniman, E. K., Soyer, H. P. and Sturm, R. A. (2019). High naevus count and MC1R red hair alleles contribute synergistically to increased melanoma risk. British Journal of Dermatology, 181 (5) bjd.17833, 1009-1016. doi: 10.1111/bjd.17833

  • Tan, Jean-Marie, Tom, Lisa N., Soyer, H. Peter and Stark, Mitchell S. (2018). Defining the molecular genetics of dermoscopic naevus patterns. Dermatology , 235 (1), 1-16. doi: 10.1159/000493892

  • Hendricks, William P D, Zismann, Victoria, Sivaprakasam, Karthigayini, Legendre, Christophe, Poorman, Kelsey, Tembe, Waibhav, Perdigones, Nieves, Kiefer, Jeffrey, Liang, Winnie, DeLuca, Valerie, Stark, Mitchell, Ruhe, Alison, Froman, Roe, Duesbery, Nicholas S, Washington, Megan, Aldrich, Jessica, Neff, Mark W, Huentelman, Matthew J, Hayward, Nicholas, Brown, Kevin, Thamm, Douglas, Post, Gerald, Khanna, Chand, Davis, Barbara, Breen, Matthew, Sekulic, Alexander and Trent, Jeffrey M (2018). Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis. PLoS Genetics, 14 (9) e1007589, e1007589. doi: 10.1371/journal.pgen.1007589

  • Stark, Mitchell S., Tan, Jean-Marie, Tom, Lisa, Jagirdar, Kasturee, Lambie, Duncan, Schaider, Helmut, Soyer, H. Peter and Sturm, Richard A. (2018). Whole-exome sequencing of acquired nevi identifies mechanisms for development and maintenance of benign neoplasms (vol 138, pg 1636, 2018). Journal of Investigative Dermatology, 138 (9), 2085-2085. doi: 10.1016/j.jid.2018.06.174

  • Stark, Mitchell S., Tan, Jean-Marie, Tom, Lisa, Jagirdar, Kasturee, Lambie, Duncan, Schaider, Helmut, Soyer, H. Peter and Sturm, Richard A. (2018). Whole-exome sequencing of acquired nevi identifies mechanisms for development and maintenance of benign neoplasms. Journal of Investigative Dermatology, 138 (7), 1636-1644. doi: 10.1016/j.jid.2018.02.012

  • Tan, J. M., Tom, L. N., Jagirdar, K., Lambie, D., Schaider, H., Sturm, R. A., Soyer, H. P. and Stark, M. S. (2018). The BRAF and NRAS mutation prevalence in dermoscopic subtypes of acquired naevi reveals constitutive MAPK pathway activation. British Journal of Dermatology, 178 (1), 191-197. doi: 10.1111/bjd.15809

  • Emran, Abdullah Al, Marzese, Diego M., Menon, Dinoop Ravindran, Stark, Mitchell S., Torrano, Joachim, Hammerlindl, Heinz, Zhang, Gao, Brafford, Patricia, Salomon, Matthew P., Nelson, Nellie, Hammerlindl, Sabrina, Gupta, Deepesh, Mills, Gordon B., Lu, Yiling, Sturm, Richard A., Flaherty, Keith, Hoon, Dave S. B., Gabrielli, Brian, Herlyn, Meenhard and Schaider, Helmut (2017). Distinct histone modifications denote early stress-induced drug tolerance in cancer. Oncotarget, 9 (9), 8206-8222. doi: 10.18632/oncotarget.23654

  • Stark, Mitchell S. (2017). Melanoma treatment guided by a panel of microRNA biomarkers. Melanoma Management, 4 (2), 71-74. doi: 10.2217/mmt-2017-0006

  • Stark, Mitchell S., Tom, Lisa N., Boyle, Glen M., Bonazzi, Vanessa F., Soyer, H. Peter, Herington, Adrian C., Pollock, Pamela M. and Hayward, Nicholas K. (2016). The 'Melanoma-enriched' microRNA miR-4731-5p acts as a tumour suppressor. Oncotarget, 7 (31), 49677-49687. doi: 10.18632/oncotarget.10109

  • Stark, Mitchell S., Bonazzi, Vanessa F., Boyle, Glen M., Palmer, Jane M., Symmons, Judith, Lanagan, Catherine M., Schmidt, Christopher W., Herington, Adrian C., Ballotti, Robert, Pollock, Pamela M. and Hayward, Nicholas K. (2015). miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma. Oncotarget, 6 (19), 17753-17763. doi: 10.18632/oncotarget.3924

  • Tembe, Varsha, Schramm, Sarah-Jane, Stark, Mitchell, Patrick, Ellis, Jayaswal, Vivek, Tang, Yue Hang, Barbour, Andrew, Hayward, Nicholas K., Thompson, John F., Scolyer, Richard A., Yang, Yee Hwa and Mann, Graham J. (2015). MicroRNA and mRNA expression profiling in metastatic melanoma reveal associations with BRAF mutation and patient prognosis. Pigment Cell and Melanoma Research, 28 (3), 254-266. doi: 10.1111/pcmr.12343

  • Stark, Mitchell S., Klein, Kerenaftali, Weide, Benjamin, Haydu, Lauren E., Pflugfelder, Annette, Tang, Yue Hang, Palmer, Jane M., Whiteman, David C., Scolyer, Richard A., Mann, Graham J., Thompson, John F., Long, Georgina V., Barbour, Andrew P., Soyer, H. Peter, Garbe, Claus, Herington, Adrian, Pollock, Pamela M. and Hayward, Nicholas K. (2015). The Prognostic and Predictive Value of Melanoma-related MicroRNAs Using Tissue and Serum: A MicroRNA Expression Analysis. EBioMedicine, 2 (7), 671-680. doi: 10.1016/j.ebiom.2015.05.011

  • Aoude, Lauren G., Pritchard, Antonia L., Robles-Espinoza, Carla Daniela, Wadt, Karin, Harland, Mark, Choi, Jiyeon, Gartside, Michael, Quesada, Victor, Johansson, Peter, Palmer, Jane M., Ramsay, Andrew J., Zhang, Xijun, Jones, Kristine, Symmons, Judith, Holland, Elizabeth A., Schmid, Helen, Bonazzi, Vanessa, Woods, Susan, Dutton-Regester, Ken, Stark, Mitchell S., Snowden, Helen, van Doom, Remco, Montgomery, Grant W., Martin, Nicholas G., Keane, Thomas M., Lopez-Otin, Carlos, Gerdes, Anne-Marie, Olsson, Hakan, Ingvar, Christian ... Hayward, Nicholas K. (2015). Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. Journal of the National Cancer Institute, 107 (2) dju408, 1-7. doi: 10.1093/jnci/dju408

  • Stark, Mitchell S. (2014). miRNAs: back seat drivers no more. Pigment Cell & Melanoma Research, 27 (4), 510-511. doi: 10.1111/pcmr.12247

  • Robles-Espinoza, Carla Daniela, Harland, Mark, Ramsay, Andrew J, Aoude, Lauren G, Quesada, Víctor, Ding, Zhihao, Pooley, Karen A, Pritchard, Antonia L, Tiffen, Jessamy C, Petljak, Mia, Palmer, Jane M, Symmons, Judith, Johansson, Peter, Stark, Mitchell S., Gartside, Michael G, Snowden, Helen, Montgomery, Grant W, Martin, Nicholas G, Liu, Jimmy Z, Choi, Jiyeon, Makowski, Matthew, Brown, Kevin M, Dunning, Alison M, Keane, Thomas M, Lopez-Otin, Carlos, Gruis, Nelleke A, Hayward, Nicholas K, Bishop, D Timothy, Newton-Bishop, Julia A and Adams, David J (2014). POT1 loss-of-function variants predispose to familial melanoma. Nature Genetics, 46 (5), 478-481. doi: 10.1038/ng.2947

  • Dutton-Regester, K., Kakavand, H., Aoude, L.G., Stark, M.S., Gartside, M.G., Johansson, P., O'Connor, L., Lanagan, C., Tembe, V., Pupo, G.M., Haydu, L.E., Schmidt, C.W., Mann, G.J., Thompson, J.F., Scolyer, R.A. and Hayward, N.K. (2013). Melanomas of unknown primary have a mutation profile consistent with cutaneous sun-exposed melanoma. Pigment Cell and Melanoma Research, 26 (6), 852-860. doi: 10.1111/pcmr.12153

  • Mould, Arne W., Pang, Zhenyi, Pakusch, Miha, Tonks, Ian D., Stark, Mitchell, Carrie, Dianne, Mukhopadhyay, Pamela, Seidel, Annica, Ellis, Jonathan J., Deakin, Janine, Wakefield, Matthew J., Krause, Lutz, Blewitt, Marnie E. and Kay, Graham F. (2013). Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation. Epigenetics and Chromatin, 6 (19) 19, 1-16. doi: 10.1186/1756-8935-6-19

  • Brooks, Kelly, Chia, Kee Ming, Spoerri, Loredana, Mukhopadhyay, Pamela, Wigan, Matthew, Stark, Mitchell, Pavey, Sandra and Gabrielli, Brian (2013). Defective decatenation checkpoint function is a common feature of melanoma. Journal of Investigative Dermatology, 134 (1), 150-158. doi: 10.1038/jid.2013.264

  • Dutton-Regester, Ken, Aoude, Lauren G., Nancarrow, Derek J., Stark, Mitchell S., O'Connor, Linda, Lanagan, Cathy, Pupo, Gulietta M., Tembe, Varsha, Carter, Candace D., O'Rourke, Michael, Scolyer, Richard A., Mann, Graham J., Schmidt, Christopher W., Herington, Adrian and Hayward, Nicholas K. (2012). Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene. Genes Chromosomes and Cancer, 51 (5), 452-461. doi: 10.1002/gcc.21932

  • Bonazzi, Vanessa F., Stark, Mitchell S. and Hayward, Nicholas K. (2012). MicroRNA regulation of melanoma progression. Melanoma Research, 22 (2), 101-113. doi: 10.1097/CMR.0b013e32834f6fbb

  • Stark, Mitchell S., Woods, Susan L., Gartside, Michael G., Bonazzi, Vanessa F., Dutton-Regester, Ken, Aoude, Lauren G., Chow, Donald, Sereduk, Chris, Niemi, Natalie M., Tang, Nanyun, Ellis, Jonathan J., Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M., Pollak, Thomas, Youngkin, David, Brooks, Bradford R., Lanagan, Catherine, Schmidt, Christopher W., Kobe, Bostjan, MacKeigan, Jeffrey P., Yin, Hongwei, Brown, Kevin M., Gibbs, Richard, Trent, Jeffrey and Hayward, Nicholas K. (2012) Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics, 44 2: 165-169. doi:10.1038/ng.1041

  • Yokoyama, Satoru, Woods, Susan L., Boyle, Glen M., Aoude, Lauren G., MacGregor, Stuart, Zismann, Victoria, Gartside, Michael, Cust, Anne E., Haq, Rizwan, Harland, Mark, Taylor, John C., Duffy, David L., Holohan, Kelly, Dutton-Regester, Ken, Palmer, Jane M., Bonazzi, Vanessa, Stark, Mitchell S., Symmons, Judith, Law, Matthew H., Schmidt, Christopher, Lanagan, Cathy, O'Connor, Linda, Holland, Elizabeth A., Schmid, Helen, Maskiell, Judith A., Jetann, Jodie, Ferguson, Megan, Jenkins, Mark A., Kefford, Richard F. ... Brown, Kevin M. (2011). A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature, 480 (7375), 99-103. doi: 10.1038/nature10630

  • MacGregor, Stuart, Montgomery, Grant W., Liu, Jimmy Z., Zhao, Zhen Zhen, Henders, Anjali K., Stark, Mitchell, Schmid, Helen, Holland, Elizabeth A., Duffy, David L., Zhang, Mingfeng, Painter, Jodie N., Nyholt, Dale R., Maskiell, Judith A., Jetann, Jodie, Ferguson, Megan, Cust, Anne E., Jenkins, Mark A., Whiteman, David C., Olsson, Hakan, Puig, Susana, Bianchi-Scarra, Giovanna, Hansson, Johan, Demenais, Florence, Landi, Maria Teresa, Debniak, Tadeusz, Mackie, Rona, Azizi, Esther, Bressac-de Paillerets, Brigitte, Goldstein, Alisa M. ... Hayward, Nicholas K. (2011). Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. Nature Genetics, 43 (11), 1114-1118. doi: 10.1038/ng.958

  • Bonazzi, Vanessa F., Nancarrow, Derek J., Stark, Mitchell S., Moser, Ralf J., Boyle, Glen M., Aoude, Lauren G., Schmidt, Christopher and Hayward, Nicholas K. (2011). Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma. PLoS One, 6 (10) e26121, 1-9. doi: 10.1371/journal.pone.0026121

  • Boyle, Glen M., Woods, Susan L., Bonazzi, Vanessa F., Stark, Mitchell S., Hacker, Elke, Aoude, Lauren G., Dutton-Regester, Ken, Cook, Anthony L., Sturm, Richard A. and Hayward, Nicholas K. (2011). Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell and Melanoma Research, 24 (3), 525-537. doi: 10.1111/j.1755-148X.2011.00849.x

  • Tyagi, Sonika, Stark, Mitchell S., Hayward, Nicholas K., Whiteman, David C. and Nancarrow, Derek J. (2010). WebFOG: A web tool to map genomic features onto genes. Biochemical and Biophysical Research Communications, 401 (3), 447-450. doi: 10.1016/j.bbrc.2010.09.077

  • Demenais, F., Mohamdi, H., Chaudru, V., Goldstein, A. M., Newton Bishop, J. A., Bishop, D. T., Kanetsky, P. A., Hayward, N. K., Gillanders, E., Elder, D. E., Avril, M. F., Azizi, E., van Belle, P., Bergman, W., Bianchi-Scarra, G., Brassac-de Paillerets, B., Calista, D., Carrera, C., Hansson, J., Harland, M., Hogg, D., Hoiom, V., Holland, E. A., Ingvar, C., Landi, M. T., Lang, J. M., Mackie, R. M., Mann, G. J., Ming, M. E. ... Melanoma Genetics Consortium (2010). Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: A GenoMEL study. Journal of the National Cancer Institute, 102 (20), 1568-1583. doi: 10.1093/jnci/djq363

  • Whiteman, D.C., Parmar, P., Fahey, P., Moore, S.P., Stark, M., Zhao, Z.Z., Montgomery, G.W., Green, A.C., Hayward, N.K., Webb, P.M., Australian Cancer Study and Aoude, Lauren (2010). Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers. Gastroenterology, 139 (1), 73-83. doi: 10.1053/j.gastro.2010.04.009

  • Dry, Jonathan R., Pavey, Sandra, Pratilas, Christine A., Harbron, Chris, Runswick, Sarah, Hodgson, Darren, Chresta, Christine, McCormack, Rose, Byrne, Natalie, Cockerill, Mark, Graham, Alexander, Beran, Garry, Cassidy, Andrew, Haggerty, Carolyn, Brown, Helen, Ellison, Gillian, Dering, Judy, Taylor, Barry S., Stark, Mitchell, Bonazzi, Vanessa, Ravishankar, Sugandha, Packer, Leisl, Xing, Feng, Solit, David B., Finn, Richard S., Rosen, Neal, Hayward, Nicholas K., French, Tim and Smith, Paul D. (2010). Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244). Cancer Research, 70 (6), 2264-2273. doi: 10.1158/0008-5472.CAN-09-1577

  • Stark, Mitchell S., Tyagi, Sonika, Nancarrow, Derek J., Boyle, Glen M., Cook, Anthony L., Whiteman, David C., Parsons, Peter G., Schmidt, Christopher, Sturm, Richard A. and Hayward, Nicholas K. (2010). Characterization of the melanoma miRNAome by deep sequencing. PLoS One, 5 (3) e9685, e9685-1-e9685-9. doi: 10.1371/journal.pone.0009685

  • Bloethner, Sandra, Mould, Arne, Stark, Mitchell and Hayward, Nicholas K. (2008). Identification of ARHGEF17, DENND2D, FGFR3, and RBI mutations in melanoma by inhibition of nonsense-mediated mRNA decay. Genes, Chromosomes and Cancer, 47 (12), 1076-1085. doi: 10.1002/gcc.20598

  • Brown, K. M., MacGregor, S., Montgomery, G. W., Craig, D. W., Zhao, Z. Z., Iyadurai, K., Henders, A. K., Homer, N., Campbell, M. J., Stark, M., Thomas, S., Schmid, H., Maskiell, J. A., Jetann, J., Ferguson, M., Stephan, D. A., Cust, A. E., Whiteman, D. C., Green, A., Olsson, H., Puig, S., Ghiorzo, P., Hansson, J., Demenais, F., Goldstein, A. M., Gruis, N. A., Elder, D. E., Newton Bishop, J., Kefford, R. F. ... Hayward, N. (2008). Common sequence variants on 20q11.22 confer melanoma susceptibility. Nature Genetics, 40 (7), 838-840. doi: 10.1038/ng.163

  • Doecke, James, Zhao, Zhen Zhen, Pandeya, Nirmala, Sadeghi, Shahram, Stark, Mitchell, Green, Adele C., Hayward, Nicholas K., Webb, Penlope M. and Whiteman, David C. (2008). Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma. International Journal of Cancer, 123 (1), 174-180. doi: 10.1002/ijc.23410

  • Harland, Mark, Goldstein, Alisa M., Kukalizch, Kairen, Taylor, Claire, Hogg, David, Puig, Susana, Badenas, Celia, Gruis, Nelleke, ter Huurne, Jeanet, Bergman, Wilma, Hayward, Nicholas K., Stark, Mitchell, Tsao, Hensin, Tucker, Margret A., Landi, Maria Teresa, Scarra, Giovanna B., Ghiorzo, Paola, Kanetsky, Peter A., Elder, David, Mann, Graham J., Holland, Elizabeth A., Bishop, D. Timothy and Newton Bishop, Julia (2008). A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL). European Journal of Cancer, 44 (9), 1269-1274. doi: 10.1016/j.ejca.2008.03.005

  • Sturm, Richard A., Duffy, David L., Zhao, Zhen Zhen, Leite, Fabio P.N., Stark, Mitchell S., Hayward, Nicholas K., Martin, Nicholas G. and Montgomery, Grant W. (2008). A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye colour. The American Journal of Human Genetics, 82 (2), 424-431. doi: 10.1016/j.ajhg.2007.11.005

  • Doecke, J D, Zhao, Z Z, Stark, M S, Green, A C, Hayward, N K, Montgomery, G W, Webb, P M and Whiteman, D C (2008). Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Cancer Epidemiology, Biomarkers & Prevention, 17 (4), 1007-1012. doi: 10.1158/1055-9965.EPI-08-0023

  • Nancarrow, Derek J., Handoko, Herlina Y., Stark, Mitchell S., Whiteman, David C. and Hayward, Nicholas K. (2007). SiDCoN: A tool to aide scoring of DNA copy number changes in SNP chip data. PLoS One, 2 (10) e1093, e1093. doi: 10.1371/journal.pone.0001093

  • Packer, Leisl M., Pavey, Sandra J., Boyle, Glen M., Stark, Mitchell S., Ayub, Ana L., Rizos, Helen and Hayward, Nicholas K. (2007). Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF. International Journal of Cancer, 121 (4), 784-790. doi: 10.1002/ijc.22725

  • Pujana, M. A., Ruiz, A., Badenas, C., Puig-Butille, J-A., Nadal, M., Stark, M., Gomez, L., Valls, J., Sole, X., Hernandez, P., Cerrato, C., Madrigal, I., de Cid, R., Aguilar, H., Capella, G., Cal, S., James, M. R., Walker, G. J., Malvehy, J., Mila, M., Hayward, N. K., Estivill, X. and Puig, S. (2007). Molecular characterization of a t(9;12)(p21;q13) balanced chromosome translocation in combination with integrative genomics analysis identifies C9orf14 as a candidate tumor-suppressor. Genes, Chromosomes & Cancer, 46 (2), 155-162. doi: 10.1002/gcc.20396

  • Loffler, Kelly A., Biondi, Christine A., Gartside, Michael, Waring, Paul, Stark, Mitchell, Serewko-Auret, Magdalena M., Muller, H. Konrad, Hayward, Nicholas K. and Kay, Graham F. (2007). Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1. International Journal of Cancer, 120 (2), 259-267. doi: 10.1002/ijc.22288

  • Goldstein, Alisa M., Chan, May, Harland, Mark, Hayward, Nicholas K., Demenais, Florence, Bishop, D. Timothy, Azizi, Esther, Bergman, Wilma, Bianchi-Scarra, Giovanna, Bruno, William, Calista, Donato, Cannon Albright, Lisa A., Chaudru, Valerie, Chompret, Agnes, Cuellar, Francisco, Elder, David E., Ghiorzo, Paola, Gillanders, Elizabeth M., Gruis, Nelleke A., Hansson, Johan, Hogg, David, Holland, Elizabeth A., Kanetsky, Peter A., Kefford, Richard F., Landi, Maria T., Lang, Julie, Leachman, Sancy A., MacKie, Rona M., Magnusson, Veronica ... Eliason, Mark (2007). Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. Journal of Medical Genetics, 44 (2), 99-106. doi: 10.1136/jmg.2006.043802

  • Stark, M. and Hayward, N. (2007). Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-denisty single-nucleotide polymorphism arrays. Cancer Research, 67 (6), 2632-2642. doi: 10.1158/0008-5472.CAN-06-4152

  • Lang, J, Hayward, N, Goldgar, D, Tsao, H, Hogg, D, Palmer, J, Stark, M, Tobias, ES and MacKie, R (2007). The M531 mutation in CDKN2A is a founder mutation that predominates in melanoma patients with Scottish ancestry. Genes Chromosomes & Cancer, 46 (3), 277-287. doi: 10.1002/gcc.20410

  • Goldstein, Alisa M., Chan, May, Harland, Mark, Gillanders, Elizabeth M., Hayward, Nicholas K., Avril, Marie-Francoise, Azizi, Esther, Bianchi-Scarra, Giovanna, Bishop, D. Timothy, Bressac-de Paillerets, Brigitte, Bruno, William, Calista, Donato, Cannon Albright, Lisa A., Demenais, Florence, Elder, David E., Ghiorzo, Paola, Gruis, Nelleke A., Hansson, Johan, Hogg, David, Holland, Elizabeth A., Kanetsky, Peter A., Kefford, Richard F., Landi, Maria Teresa, Lang, Julie, Leachman, Sancy A., MacKie, Rona M., Magnusson, Veronica, Mann, Graham J., Niendorf, Kristin ... Melanoma Genetics Consortium (GenoMEL) (2006). High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL. Cancer research, 66 (20), 9818-9828. doi: 10.1158/0008-5472.CAN-06-0494

  • Packer, Leisl, Pavey, Sandra, Parker, Andrew, Stark, Mitchell, Johansson, Peter, Clarke, Belinda, Pollock, Pamela, Ringner, Markus and Hayward, Nicholas (2006). Osteopontin is a Downstream Effector of the PI3-kinase Pathway in Melanomas that is Inversely Correlated with Functional PTEN. Carcinogenesis, 27 (9), 1778-1786. doi: 10.1093/carcin/bgl016

  • Curtin, John A., Stark, Mitchell S., Pinkel, Daniel, Hayward, Nicholas K. and Bastian, Boris C. (2006). PI3-Kinase Subunits Are Infrequent Somatic Targets in Melanoma. Journal of Investigative Dermatology, 126 (7), 1660-1663. doi: 10.1038/sj.jid.5700311

  • Stark, M., Puig-Butille, J. A., Walker, G., Badenas, C., Malvehy, J., Hayward , N. and Puig, S. (2006). Mutation of the tumour suppressor p33ING1b is rare in melanoma. British Journal of Dermatology, 155 (1), 94-99. doi: 10.1111/j.1365-2133.2006.07274.x

  • James, Michael R., Dumeni, Troy, Stark, Mitchell S., Duffy, David L., Montgomery, Grant W., Martin, Nicholas G. and Hayward, Nicholas K. (2006). Rapid screening of 4000 individuals for germ-line variations in the BRAF gene. Clinical Chemistry, 52 (9), 1675-1678. doi: 10.1373/clinchem.2006.070169

  • James, Michael R., Roth, Richard B., Shi, Michael M., Kammerer, Stefan, Nelson, Matthew R., Stark, Mitchell S., Dumenil, Troy, Montgomery, Grant W., Hayward, Nicholas K., Martin, Nicholas G., Braun, Andreas and Duffy, David L. (2005). BRAF Polymorphisms and Risk of Melanocytic Neoplasia. Journal of Investigative Dermatology, 125 (6), 1252-1258. doi: 10.1111/j.0022-202X.2005.23937.x

  • Zuidervaart, W., van Nieuwpoort, F., Stark, M., Dijkman, R., Packer, L., Borgstein, A. -M., Pavey, S., van der Velden, P., Out, C., Jager, M. J., Hayward, N. K. and Gruis, N. A. (2005). Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS. British Journal of Cancer, 92 (11), 2032-2038. doi: 10.1038/sj.bjc.6602598

  • Pavey, Sandra, Johansson, Peter, Packer, Leisl, Taylor, Jennifer, Stark, Mitchell, Pollock, Pamela M., Walker, Graeme J., Boyle, Glen M., Harper, Ursula, Cozzi, Sarah-Jane, Hansen, Katherine, Yudt, Laura, Schmidt, Chris, Hersey, Peter, Ellem, Kay A. O., O'Rourke, Michael G. E., Parsons, Peter G., Meltzer, Paul, Ringnér, Markus and Hayward, Nicholas K. (2004). Microarray expression profiling in melanoma reveals a BRAF mutation signature. Oncogene, 23 (23), 4060-4067. doi: 10.1038/sj.onc.1207563

  • Biondi, C. A., Gartside, M. G., Waring, P., Loffler, K. A., Stark, M. S., Magnuson, M. A., Kay, G. F. and Hayward, N. K. (2004). Conditional inactivation of the Men1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Molecular And Cellular Biology, 24 (8), 3125-3131. doi: 10.1128/MCB.24.8.3125-3131.2004

  • Vajdic, C, Kricker, A, Duffy, DL, Aitken, JF, Stark, M, ter Huurne, JAC, Martin, NG, Armstrong, BK and Hayward, NK (2003). Ocular melanoma is not associated with CDKN2A or MC1R variants - a population-based study. Melanoma Research, 13 (4), 409-413. doi: 10.1097/01.cmr.0000056244.56735.28

  • Pollock, Pamela M., Harper, Ursula L., Hansen, Katherine S., Yudt, Laura M., Stark, Mitchell, Robbins, Christiane M., Moses, Tracy Y., Hostetter, Galen, Wagner, Urs, Kakareka, John, Salem, Ghadi, Pohida, Tom, Heenan, Peter, Duray, Paul, Kallioniemi, Olli, Hayward, Nicholas K., Trent, Jeffrey M. and Meltzer, Paul S. (2003). High frequency of BRAF mutations in nevi. Nature Genetics, 33 (1), 19-20. doi: 10.1038/ng1054

  • Gillanders, Elizabeth, Juo, Suh-Hang Hank, Holland, Elizabeth A., Jones, MaryPat, Nancarrow, Derek, Freas-Lutz, Diana, Sood, Raman, Park, Naeun, Faruque, Mezbah, Markey, Carol, Kefford, Richard F., Palmer, Jane, Bergman, Wilma, Bishop, D. Timothy, Tucker, Margaret A., Bressac-de Paillerets, Brigitte, Hansson, Johan, The Lund Melanoma Study Group, Stark, Mitchell, Gruis, Nelleke, Newton Bishop, Julia, Goldstein, Alisa M., Bailey-Wilson, Joan E., Mann, Graham J., Hayward, Nicholas, Trent, Jeffrey, Martin, Nicholas G. and The Melanoma Genetics Consortium (2003). Localization of a novel melanoma susceptibility locus to 1p22. American Journal of Human Genetics, 73 (2), 301-313. doi: 10.1086/377140

  • Pollock, Pamela M., Stark, Mitchell S., Palmer, Jane M., Walters, Marilyn K., Aitken, Joanne F., Martin, Nicholas G. and Hayward, Nicholas K. (2001). Mutation analysis of the CDKN2A promoter in Australian melanoma families. Genes Chromosomes and Cancer, 32 (1), 89-94. doi: 10.1002/gcc.1170

  • Welch, John, Millar, Doug, Goldman, Alana, Heenan, Peter, Stark, Mitchell, Eldon, Michael, Clark, Susan, Martin, Nicholas G. and Hayward, Nicholas K. (2001). Lack of Genetic and Epigenetic Changes in CDKN2A in Melanocytic Nevi [Letter to the editor]. Journal of Investigative Dermatology, 117 (2), 383-384. doi: 10.1046/j.0022-202x.2001.01391.x

  • Box, N. F., Duffy, D. L., Chen, W., Stark, M., Martin, N. G., Sturm, R. A. and Hayward, N. K. (2001). MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. American Journal of Human Genetics, 69 (4), 765-773. doi: 10.1086/323412

Conference Publication

  • Kan, C., Crovetto, N., Landreneau, R., Li, L., Soyer, H., Stark, M. S. and Gunn, S. (2020). Identification of a novel microrna panel: potential biomarkers for non-small cell lung cancer. Southern Regional Meeting of the American-Federation-for-Medical-Research (AFMR), New Orleans, LA, United States, 13-15 February 2020. London, United Kingdom: B M J Group. doi: 10.1136/jim-2020-SRM.565

  • Emran, A., Marzese, D. M., Menon, D. R., Stark, M., Torrano, J., Hammerlindl, H., Zhang, G., Brafford, P., Hammerlindl, S., Gupta, D., Mills, G. B., Lu, Y., Flaherty, K., Sturm, R., Hoon, D. S. B., Gabrielli, B., Herlyn, M. and Schaider, H. (2018). Distinct epigenetic remodelling defines early stress-induced drug tolerance in melanoma. Australasian College of Dermatologists, 51st Annual Scientific Meeting, Gold Coast, QLD, Australia , 19–22 May 2018. Richmond, VIC, Australia: Wiley-Blackwell Publishing. doi: 10.1111/ajd.16_12815

  • Stark, Mitchell S., Tan, Jean-Marie, Tom, Lisa, Jagirdar, Kasturee, Lambie, Duncan, Schaider, Helmut, Soyer, H. Peter and Sturm, Richard A. (2018). Whole-exome sequencing of acquired nevi identifies novel mechanisms for development and maintenance of benign neoplasms. Annual Meeting of the American Association for Cancer Research (AACR), Chicago, Illinois, 14-18 April 2018. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2018-5376

  • Tan, J-M., Tom, L., Jagirdar, K., Lambie, D., Sturm, R., Soyer, P. and Stark, M. (2017). The prevalence of BRAF and NRAS in dermoscopic subtypes of acquired naevi. Australasian College of Dermatologists 50th Annual Scientific Meeting, Darling Harbour, New South Wales, Australia, 6–9 May 2017. Richmond, VIC., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.21_12652

  • Stark, M., Gray, E., Ziman, M., Soyer, H. P. and Schaider, H. (2016). Can melanoma treatment be guided by a panel of predictive and prognostic microRNA biomarkers?. 16th World Congress on Cancers of the Skin , Vienna, Austria, 31 August - 3 September 2016. Philadelphia, PA United States: Lippincott Williams & Wilkins.

  • Emran, A. A., Menon, D. R., Marzese, D., Hammerlindl, H., Brafford, P., Stark, M., Huang, S., Hammerlindl, S., Gupta, D., Soyer, P., Sturm, R., Hoon, D., Gabrielli, B., Herlyn, M. and Schaider, H. (2016). Epigenetic remodelling of H3K9Me3 leads to early stress induced drug tolerance in cancer. Asia‐Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell.

  • Ahmed, F., Tonnessen, C., Spoerri, L., Daignault, S., Stark, M., Schaider, H., Hill, M. and Haass, N. (2016). Identification of unique molecular signatures of differentially cycling tumour cell subpopulations in a 3D melanoma model. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584

  • Wright, C. M., Francis, S. M. Savarimuthu, Sriram, K. B., Stark, M. S., Hayward, N. K., Yang, I. A., Bowman, R. V. and Fong, K. M. (2013). Distinct profiles for lung cancer and its major subtypes. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, Darwin, NT, Australia, 22-27 March 2013. Richmond, VIC, Australia: Wiley-Blackwell Publishing. doi: 10.1111/resp.12045

  • Wright, C. M., Francis, S. M. S., Sriram, K. B., Quinn, K. R., Stark, M. S., Hayward, N. K., Yang, I. A., Bowman, R. V. and Fong, K. M. (2011). Mapping the lung cancer methylome. 3rd Australian Lung Cancer Conference (ALCC), Melbourne VIC, Australia, 6-9 October 2010. Philadelphia PA, United States: Lippincott Williams & Wilkins.

  • Pollock, Pamela. M., Stark, Mitchell, Palmer, Jane M., Walters, Marilyn K., Martin, Nick G., Green, Adele C. and Hayward, Nicholas K. (2001). Mutation analysis of the CDKN2A promoter in Australian melanoma families. Unknown, Unknown, Unknown. New York, NY, United States: Springer Nature. doi: 10.1038/87254

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Australian domestic or on-shore International student applicants only. The Stark Lab is seeking talented and highly motivated PhD student(s) to join their team at The Dermatology Research Centre, The University of Queensland Diamantina Institute. Various projects are available relating to 2 major research streams: microRNA biomarkers for melanoma progression and the development a Genomics Atlas of pre-skin cancer lesions.If you are interested to hear more about the projects which harness the latest cutting edge technologies (e.g. spatial profiling), then please send your current CV, Academic Transcript, and Cover Letter to m.stark@uq.edu.au Living stipend scholarships and Tuition Scholarships are available for application from the UQ Graduate School which are currently a Base Stipend of $28,597 per annum tax free (2021 rate), indexed annually, Overseas Student Health Cover (OSHC). Top-up Scholarships (tax-free) may also be available. Applications for scholarships close 28th March for commencement in July 2021.