Dr Abu Sina

Postdoctoral Research Fellow

Australian Institute for Bioengineering and Nanotechnology
a.sina@uq.edu.au
+61 7 334 64176

Overview

Dr Abu Sina is currently a postdoctoral research fellow at the Australian Institute for Bioengineering & Nanotechnology (AIBN), The University of Queensland. He obtained his PhD from the University of Queensland in 2017. He also has a joint teaching position (currently on leave) as an Assistant Professor at the Department of Biochemistry and Molecular Biology, Shahjalal University of Science & Technology, Bangladesh. Prior to joining the academia, he held positions in multinational companies such as Berger Paints and Beximco Limited. His experience in multinational companies enabled him to achieve diverse knowledge on industrial challenges particularly in the environment of large business sectors. Dr Abu is currently working with former federation fellow Prof Matt Trau and leading a small group within the Trau Lab. In his short research career, he has demonstrated a high impact track record with 16 publications including 14 peer-reviewed articles and 2 book chapters. Most of his articles are published in leading international journals such as Nanoscale, Analytical Chemistry, Biosensors and Bioelectronics, Chemical Communications and Scientific Reports. He also presented at many national and international conferences.

Research Impacts

Dr. Abu Sina pioneered the interfacial biosensing techniques and recognized for his contribution to the field of bionanotechnology and molecular diagnostics. His research is focused on developing translational directed technologies which could have immediate clinical prospects. Some of his major discoveries include interfacial biosensing techniques for the detection of DNA methylation, multiplex micro-devices for the detection of cancer biomarkers and label-free and real-time detection of clinically relevant exosomes.

Qualifications

  • Doctor of Philosophy, The University of Queensland

Publications

View all Publications

Available Projects

  • Methylation of DNA is a type of epigenetic signatures that defines the eukaryotic cell’s identity by regulating gene expression. Aberrant methylation in the genome can deregulate the gene expression pathways leading to diseases like cancer. Thus, DNA methylation has been regarded as one of the important biomarkers for cancer. Recent years have seen tremendous advancement in methylation based biomarker discovery providing abundant information about the genomic printing. However, cancer is a versatile disease that often needs multiple biomarker analysis for accurate detection. Current practice in detecting methylation biomarkers in clinic is largely affected by expensive sequencing technique. Recent advancements in electrochemical and optical biosensors have shown great promise in developing inexpensive multiplex platform. Despite of their significant improvement in sensitivity, these methods are restricted by major technological challenges including functionalization of sensor surface, long analysis procedure and invasive sampling. We have recently developed an interfacial biosensing technique to identify DNA methylation using gold-DNA affinity which obviates the need for sensor surface modification. In this study, we aim to develop a novel multiplex micro-device comprising an array of microelectrodes for directly detecting the genomic methylation biomarkers with the mechanism of interfacial adsorption between DNA and metal surfaces. These microelectrodes can significantly increase the assay sensitivity due to the high signal to noise ratio. We believe that this micro-fabricated multiplex platform will find broad applications as simple diagnostic tool in the clinic.

View all Available Projects

Publications

Book Chapter

Journal Article

Conference Publication

  • Shiddiky, Muhammad J, Sina, Abu Ali Ibn, Carracosa, Laura G, Palanisamy, Ramkumar, Rauf, Sakandar and Trau, Matt (2014). Methylsorb: A Simple Method for Quantifying DNA Methylation Using DNA-gold Affinity Interactions. In: ICECE 2014, 8th International Conference on Electrical and Computer Engineering. 8th International Conference on Electrical and Computer Engineering, Dhaka, Bangladesh, (17-20). 20-22 December 2014. doi:10.1109/ICECE.2014.7027002

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Methylation of DNA is a type of epigenetic signatures that defines the eukaryotic cell’s identity by regulating gene expression. Aberrant methylation in the genome can deregulate the gene expression pathways leading to diseases like cancer. Thus, DNA methylation has been regarded as one of the important biomarkers for cancer. Recent years have seen tremendous advancement in methylation based biomarker discovery providing abundant information about the genomic printing. However, cancer is a versatile disease that often needs multiple biomarker analysis for accurate detection. Current practice in detecting methylation biomarkers in clinic is largely affected by expensive sequencing technique. Recent advancements in electrochemical and optical biosensors have shown great promise in developing inexpensive multiplex platform. Despite of their significant improvement in sensitivity, these methods are restricted by major technological challenges including functionalization of sensor surface, long analysis procedure and invasive sampling. We have recently developed an interfacial biosensing technique to identify DNA methylation using gold-DNA affinity which obviates the need for sensor surface modification. In this study, we aim to develop a novel multiplex micro-device comprising an array of microelectrodes for directly detecting the genomic methylation biomarkers with the mechanism of interfacial adsorption between DNA and metal surfaces. These microelectrodes can significantly increase the assay sensitivity due to the high signal to noise ratio. We believe that this micro-fabricated multiplex platform will find broad applications as simple diagnostic tool in the clinic.