Dr Selvakumar Edwardraja

Research Fellow

Australian Institute for Bioengineering and Nanotechnology
s.edwardraja@uq.edu.au
+61 7 334 64265

Overview

Research Interests

  • Protein Based Biosensor Development

Qualifications

  • PhD, PNU

Publications

  • Guo, Zhong, Parakra, Rinky D., Xiong, Ying, Johnston, Wayne A., Walden, Patricia, Edwardraja, Selvakumar, Moradi, Shayli Varasteh, Ungerer, Jacobus P. J., Ai, Hui-wang, Phillips, Jonathan J. and Alexandrov, Kirill (2022). Engineering and exploiting synthetic allostery of NanoLuc luciferase. Nature Communications, 13 (1) 789, 789. doi: 10.1038/s41467-022-28425-2

  • Farokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001

  • Bollella, Paolo, Edwardraja, Selvakumar, Guo, Zhong, Vickers, Claudia E., Whitfield, Jason, Walden, Patricia, Melman, Artem, Alexandrov, Kirill and Katz, Evgeny (2021). Connecting artificial proteolytic and electrochemical signaling systems with caged messenger peptides. ACS Sensors, 6 (10), 3596-3603. doi: 10.1021/acssensors.1c00845

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

  • This project aims to develop a novel molecular evolution platform technology for the rapid selection of high value target binding molecules from diverse molecular libraries using an electrically activated nanofluidic chip coated with target. Significant outcomes from the project is the controlled selection of target binding molecules that is not possible with current methods and improved understanding of nanoforce driven molecular collisions on nano-bioengineered surfaces. This provides significant benefits, creating new knowledge in nanomaterials and advanced manufacturing of nanofabricated devices, creating commercial interest and positioning Australia at the forefront of molecular discovery technology, a highly valuable global market.

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Publications

Journal Article

Conference Publication

  • Guo, Zhong, Whitfield, Jason, Edwardraja, Selvakumar and Alexandrov, Kirill (2018). Connecting biochemistry and elelctronics with artifical allosteric protein biosensors. 2018 International Conference Laser Optics, ICLO 2018, St. Petersburg, Russia, 4-8 June 2018. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers Inc.. doi: 10.1109/LO.2018.8435862

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • This project aims to develop a novel molecular evolution platform technology for the rapid selection of high value target binding molecules from diverse molecular libraries using an electrically activated nanofluidic chip coated with target. Significant outcomes from the project is the controlled selection of target binding molecules that is not possible with current methods and improved understanding of nanoforce driven molecular collisions on nano-bioengineered surfaces. This provides significant benefits, creating new knowledge in nanomaterials and advanced manufacturing of nanofabricated devices, creating commercial interest and positioning Australia at the forefront of molecular discovery technology, a highly valuable global market.