The University of Queensland

Predicting risk of serious bacterial infections in febrile children in the emergency department

Irwin, Adam D, Grant, Alison, Williams, Rhian, Kolamunnage-Dona, Ruwanthi, Drew, Richard J, Paulus, Stephane, Jeffers, Graham, Williams, Kim, Breen, Rachel, Preston, Jennifer, Appelbe, Duncan, Chesters, Christine, Newland, Paul, Marzouk, Omnia, McNamara, Paul S, Diggle, Peter J and Carrol, Enitan D (2017). Predicting risk of serious bacterial infections in febrile children in the emergency department. Pediatrics, 140 (2) e20162853. doi: 10.1542/peds.2016-2853

Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT)

Irwin, Adam D., Coin, Lachlan J. M., Harris, Patrick N. A., Cotta, Menino Osbert, Bauer, Michelle J., Buckley, Cameron, Balch, Ross, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Beatson, Scott A., Forde, Brian M., Paterson, David, Clark, Julia, Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Schlapbach, Luregn J. and Roberts, Jason A. (2021). Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT). Frontiers in Cellular and Infection Microbiology, 11. doi: 10.3389/fcimb.2021.667680

New microbiological techniques for the diagnosis of bacterial infections and sepsis in ICU including point of care

Peri, Anna Maria, Stewart, Adam, Hume, Anna, Irwin, Adam and Harris, Patrick N A (2021). New microbiological techniques for the diagnosis of bacterial infections and sepsis in ICU including point of care. Current Infectious Disease Reports, 23 (8) 12, 12. doi: 10.1007/s11908-021-00755-0

Role of C reactive protein and procalcitonin in the diagnosis of lower respiratory tract infection in children in the outpatient setting

Pérez-López, Andrés, Irwin, Adam, Rodrigo, Carlos and Prat-Aymerich, Cristina (2021). Role of C reactive protein and procalcitonin in the diagnosis of lower respiratory tract infection in children in the outpatient setting. BMJ, 373 (11) n1409, n1409. doi: 10.1136/bmj.n1409

The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children

Channon-Wells, S., Kwok, M., Booth, J., Bamford, A., Konstanty, P., Hatcher, J., Dixon, G., Diggle, P. J., Standing, J. F. and Irwin, A. D. (2021). The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children. Journal of Antimicrobial Chemotherapy. doi: 10.1093/jac/dkab187

Normal saline and lung recruitment with paediatric endotracheal suction (NARES): a pilot, factorial, randomised controlled trial

Schults, Jessica A., Cooke, Marie, Long, Debbie, Schibler, Andreas, Ware, Robert S., Charles, Karina, Irwin, Adam and Mitchell, Marion L. (2021). Normal saline and lung recruitment with paediatric endotracheal suction (NARES): a pilot, factorial, randomised controlled trial. Australian Critical Care. doi: 10.1016/j.aucc.2021.01.006

Rapid detection of NDM and VIM carbapenemase encoding genes by recombinase polymerase amplification and lateral flow–based detection

Ayfan, Abdulrahman K. S., Macdonald, Joanne, Harris, Patrick N. A., Heney, Claire, Paterson, David L., Trembizki, Ella, Wang, Claire Y. T., Whiley, David M., Zowawi, Hosam M. and Irwin, Adam D. (2021). Rapid detection of NDM and VIM carbapenemase encoding genes by recombinase polymerase amplification and lateral flow–based detection. European Journal of Clinical Microbiology & Infectious Diseases. doi: 10.1007/s10096-021-04267-6

The relevance of probiotics in Caesarean-born neonates

Sidjabat, Hanna E., Alsaggaf, Alaa Mohammed Ali, Gopalakrishna, Akshatha, Nadar, Evelyn, Irwin, Adam and Koorts, Pieter (2020). The relevance of probiotics in Caesarean-born neonates. Microbiology Australia, 41 (2), 75-81. doi: 10.1071/ma20020

Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study

Warris, Adilia, Pana, Zoi-Dorothea, Oletto, Andrea, Lundin, Rebecca, Castagnola, Elio, Lehrnbecher, Thomas, Groll, Andreas H., Roilides, Emmanuel, Andersen, Cecilie T., Arendrup, Maiken C., Arsenijevic, Valentina Arsic, Bianchini, Sonia, von Both, Ulrich, Chmelnik, Martin, Controzzi, Tiziana, Emonts, Marieke, Esposito, Susanna, Ferreras-Antolin, Laura, Henriet, Stefanie, Iosifidis, Elias, Irwin, Adam, Kopsidas, John, Lagrou, Katrien, Lyall, Hermione, Casteleiro, Angela Manzanares, Mesini, Alessio, Olbrich, Peter, Paulus, Stephane, Lausch, Karen Rokkedal ... EUROCANDY Study Group (2019). Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study. The Pediatric Infectious Disease Journal, 39 (2), 1-120. doi: 10.1097/INF.0000000000002530

Neonatal Antifungal Consumption Is Dominated by Prophylactic Use; Outcomes From The Pediatric Antifungal Stewardship: Optimizing Antifungal Prescription Study

Ferreras-Antolín, Laura, Irwin, Adam, Atra, Ayad, Dermirjian, Alicia, Drysdale, Simon B, Emonts, Marieke, McMaster, Paddy, Paulus, Stephane, Patel, Sanjay, Kinsey, Sally, Vergnano, Stefania, Whittaker, Elisabeth and Warris, Adilia (2019). Neonatal Antifungal Consumption Is Dominated by Prophylactic Use; Outcomes From The Pediatric Antifungal Stewardship: Optimizing Antifungal Prescription Study. The Pediatric infectious disease journal, 38 (12), 1-1223. doi: 10.1097/INF.0000000000002463

Case ascertainment in active paediatric surveillance systems: a report from the British Paediatric Surveillance Unit Ascertainment Group

Lynn, Richard M, Reading, Richard, BPSU Ascertainment Group and Irwin, Adam (2019). Case ascertainment in active paediatric surveillance systems: a report from the British Paediatric Surveillance Unit Ascertainment Group. Archives of disease in childhood, 105 (1), 62-68. doi: 10.1136/archdischild-2019-317401

Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries

Hsia, Yingfen, Lee, Brian R., Versporten, Ann, Yang, Yonghong, Bielicki, Julia, Jackson, Charlotte, Newland, Jason, Goossens, Herman, Magrini, Nicola, Sharland, Mike, Teston, L., Cheung, K., Koning, S., Grimwood, K., Cross, J., da Silva, A., Benadof, D., Zhang, W. S., Zhao, W., Liu, G., Shen, K. L., Yao, K. H., Zheng, Y. J., Deng, J. K., Zhang, J. S., Wang, Y., Jiang, X. Y., Tian, D. Y., Jing, C. M. ... Gawrys, G. (2019). Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries. The Lancet Global Health, 7 (7), E861-E871. doi: 10.1016/S2214-109X(19)30071-3

Revising paediatric vancomycin dosing accounting for nephrotoxicity in a pharmacokinetic-pharmacodynamic model

Kloprogge, Frank, Hill, Louise, Booth, John, Klein, Nigel, Irwin, Adam, Dixon, Garth and Standing, Joseph F (2019). Revising paediatric vancomycin dosing accounting for nephrotoxicity in a pharmacokinetic-pharmacodynamic model. Antimicrobial Agents and Chemotherapy, 63 (5) e00067-19. doi: 10.1128/aac.00067-19

Detection of epidemic scarlet fever group A Streptococcus in Australia

Walker, Mark J., Brouwer, Stephan, Forde, Brian M., Worthing, Kate A., McIntyre, Liam, Sundac, Lana, Maloney, Sam, Roberts, Leah W., Barnett, Timothy C., Richter, Johanna, Cork, Amanda J., Irwin, Adam D., You, Yuanhai, Zhang, Jianzhong, Dougan, Gordon, Yuen, K. Y., Nizet, Victor, Beatson, Scott A., Grimwood, Keith and Davies, Mark R. (2019). Detection of epidemic scarlet fever group A Streptococcus in Australia. Clinical Infectious Diseases, 69 (7), 1232-1234. doi: 10.1093/cid/ciz099

A case for reduced frequency of CD4 count monitoring for children on combination antiretroviral therapy with consistently undetectable HIV viral load

Johnson, S. M., Standing, J. F., Klein, N., Irwin, A. D., Shingadia, D., Lonsdale, D. O., Gilmour, K. C., Flynn, J., Manns, C., Clapson, M. and Bamford, A. (2019). A case for reduced frequency of CD4 count monitoring for children on combination antiretroviral therapy with consistently undetectable HIV viral load. HIV Medicine, 20 (4), e8-e9. doi: 10.1111/hiv.12706

Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children (vol 58, pg 53, 2019)

Boonsathorn, Sophida, Cheng, Iek, Kloprogge, Frank, Alonso, Carlos, Lee, Charmion, Doncheva, Bilyana, Booth, John, Chiesa, Robert, Irwin, Adam and Standing, Joseph F. (2019). Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children (vol 58, pg 53, 2019). Clinical Pharmacokinetics, 58 (1), 141-141. doi: 10.1007/s40262-018-0722-x

Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children

Boonsathorn, Sophida, Cheng, Iek, Kloprogge, Frank, Alonso, Carlos, Lee, Charmion, Doncheva, Bilyana, Booth, John, Chiesa, Robert, Irwin, Adam and Standing, Joseph F. (2018). Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children. Clinical Pharmacokinetics, 58 (1), 1-9. doi: 10.1007/s40262-018-0658-1

Question 2: are three malaria tests necessary in children returning from the tropics with fever?

Wilson, Isabel Emily, Shingadia, Delane, Yeung, Shunmay, Riordan, Andrew and Irwin, Adam David (2018). Question 2: are three malaria tests necessary in children returning from the tropics with fever?. Archives of Disease in Childhood, 103 (1), 109-112. doi: 10.1136/archdischild-2017-313843

Predicting risk of serious bacterial infections in febrile children in the emergency department

Irwin, Adam D, Grant, Alison, Williams, Rhian, Kolamunnage-Dona, Ruwanthi, Drew, Richard J, Paulus, Stephane, Jeffers, Graham, Williams, Kim, Breen, Rachel, Preston, Jennifer, Appelbe, Duncan, Chesters, Christine, Newland, Paul, Marzouk, Omnia, McNamara, Paul S, Diggle, Peter J and Carrol, Enitan D (2017). Predicting risk of serious bacterial infections in febrile children in the emergency department. Pediatrics, 140 (2) e20162853. doi: 10.1542/peds.2016-2853

Acute infectious hepatitis in hospitalised children: a British Paediatric Surveillance Unit study

Braccio, Serena, Irwin, Adam, Riordan, Andrew, Shingadia, Delane, Kelly, Deirdre A., Bansal, Sanjay, Ramsay, Mary and Ladhani, Shamez N. (2017). Acute infectious hepatitis in hospitalised children: a British Paediatric Surveillance Unit study. Archives of Disease in Childhood, 102 (7), 624-628. doi: 10.1136/archdischild-2016-311916

Predictors of fever-related admissions to a paediatric assessment unit, ward and reattendances in a South London emergency department: the CABIN 2 study

Bustinduy, Amaya L., Chis Ster, Irina, Shaw, Rebecca, Irwin, Adam, Thiagarajan, Jaiganesh, Beynon, Rhys, Ladhani, Shamez, Sharland, Mike and CABIN network (2017). Predictors of fever-related admissions to a paediatric assessment unit, ward and reattendances in a South London emergency department: the CABIN 2 study. Archives of Disease in Childhood, 102 (1), 22-28. doi: 10.1136/archdischild-2016-310494

Supporting decisions to increase the safe discharge of children with febrile illness from the emergency department: a systematic review and meta-analysis

Irwin, A. D., Wickenden, J., Le Doare, K., Ladhani, S. and Sharland, M. (2016). Supporting decisions to increase the safe discharge of children with febrile illness from the emergency department: a systematic review and meta-analysis. e ADC, 101 (3), 259-66. doi: 10.1136/archdischild-2015-309056

Etiology of childhood bacteremia and timely antibiotics administration in the emergency department

Irwin, Adam D., Drew, Richard J., Marshall, Philippa, Nguyen, Kha, Hoyle, Emily, Macfarlane, Kate A., Wong, Hoying F., Mekonnen, Ellen, Hicks, Matthew, Steele, Tom, Gerrard, Christine, Hardiman, Fiona, McNamara, Paul S., Diggle, Peter J. and Carrol, Enitan D. (2015). Etiology of childhood bacteremia and timely antibiotics administration in the emergency department. Pediatrics, 135 (4), 635-642. doi: 10.1542/peds.2014-2061

Improving antibiotic prescribing for children in the resource-poor setting

Le Doare, Kirsty, Barker, Charlotte I. S., Irwin, Adam and Sharland, Mike (2015). Improving antibiotic prescribing for children in the resource-poor setting. British Journal of Clinical Pharmacology, 79 (3), 446-455. doi: 10.1111/bcp.12320

Commentaries on ‘Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections’ with a response from the review authors

Sabhaney, Vikram, Enarson, Paul, Irwin, Adam D., Carrol, Enitan D., Schuetz, Philipp, Briel, Matthias, Bucher, Heiner C. and Mueller, Beat (2013). Commentaries on ‘Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections’ with a response from the review authors. Evidence-Based Child Health, 8 (4), 1372-1375. doi: 10.1002/ebch.1928

Measuring antibiotic prescribing in hospitalised children in resource-poor countries: a systematic review

Irwin, Adam and Sharland, Mike (2013). Measuring antibiotic prescribing in hospitalised children in resource-poor countries: a systematic review. Journal of Paediatrics and Child Health, 49 (3), 185-192. doi: 10.1111/j.1440-1754.2011.02126.x

Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children

Irwin, Adam D., Marriage, Fiona, Mankhambo, Limangeni A., Jeffers, Graham, Kolamunnage-Dona, Ruwanthi, Guiver, Malcolm, Denis, Brigitte, Molyneux, Elizabeth M., Molyneux, Malcolm E., Day, Philip J. and Carrol, Enitan D. (2012). Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children. BMC Medical Genomics, 5 13. doi: 10.1186/1755-8794-5-13

Procalcitonin

Irwin, Adam D. and Carrol, Enitan D. (2011). Procalcitonin. Archives of Disease in Childhood-Education and Practice Edition, 96 (6), 228-233. doi: 10.1136/archdischild-2011-300178

Predicting a patient's choice of dialysis modality: experience in a United Kingdom renal department

Little, Jane, Irwin, Adam, Marshall, Tim, Rayner, Hugh and Smith, Stephen (2001). Predicting a patient's choice of dialysis modality: experience in a United Kingdom renal department. American Journal of Kidney Diseases, 37 (5), 981-986. doi: 10.1016/S0272-6386(05)80014-9

Rapid and sensitive molecular detection of antimicrobial resistance (AMR); towards point-of-care testing in low resource settings

Ayfan, A., Ertl, N., Whiley, D., Paterson, D., Heney, C., Harris, P., Macdonald, J., Irwin, A. and Zowawi, H. (2020). Rapid and sensitive molecular detection of antimicrobial resistance (AMR); towards point-of-care testing in low resource settings. GCCMID 2019, Dubai, United Arab Emirates, 6-9 November 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jiph.2020.01.059

Neonatal observational vascular access (NOVA): an Australian audit

August, Deanne, Ullman, Amanda, New, Karen, McIntyre, Colette, Smith, Patricia, Koorts, Pieter, Irwin, Adam, Cobbald, Linda, Lack, Gill, Takashima, Mari, Foxcroft, Katie and Marsh, Nicole (2019). Neonatal observational vascular access (NOVA): an Australian audit. 3rd Congress of Joint European Neonatal Societies (jENS), Masstricht, Netherlands, 17-21 September 2019. New York, United States: Nature Publishing Group.

A2.1  A comparison of metrics to evaluate trends in antimicrobial consumption in a tertiary children’s hospital

Kwok, M., Booth, J., Konstanty, P., Standing, J.F. and Irwin, A.D. (2017). A2.1  A comparison of metrics to evaluate trends in antimicrobial consumption in a tertiary children’s hospital. Great Ormond Street Hospital Conference, Nottingham, United Kingdom, 21–22 June, 2017. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/archdischild-2017-084620.21