Dr Adam Irwin is a NHMRC Emerging Leadership Fellow and conjoint Senior Lecturer in paediatric infectious disease at The University of Queensland and Queensland Children’s Hospital. His research focuses on early recognition of invasive infections and sepsis, and optimal use of antimicrobials including the most appropriate treatment of healthcare-associated and antimicrobial resistant infections in children. He is the medical co-chair of the Queensland Paediatric Sepsis Program which was awarded a Global Sepsis Alliance award in 2020, and Queensland Health Excellence awards in 2022 for Healthcare Delivery and Consumer Engagement.
Adam studied at the University of Birmingham Medical School and completed training in Paediatric Infectious Disease and Immunology in London. He was awarded his PhD by the University of Liverpool Institute of Infection and Global Health in 2016. Prior to relocating to Queensland, he was secretary of the British Paediatric Allergy, Immunity and Infection Group.
Wen, Sophie C. H., Ezure, Yukiko, Rolley, Lauren, Spurling, Geoff, Lau, Colleen L., Riaz, Saba, Paterson, David L. and Irwin, Adam D. (2021). Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis. PLoS Medicine, 18 (9) e1003787, 1-20. doi: 10.1371/journal.pmed.1003787
Channon-Wells, S., Kwok, M., Booth, J., Bamford, A., Konstanty, P., Hatcher, J., Dixon, G., Diggle, P. J., Standing, J. F. and Irwin, A. D. (2021). The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children. Journal of Antimicrobial Chemotherapy, 76 (9), 2464-2471. doi: 10.1093/jac/dkab187
Journal Article: Predicting risk of serious bacterial infections in febrile children in the emergency department
Irwin, Adam D, Grant, Alison, Williams, Rhian, Kolamunnage-Dona, Ruwanthi, Drew, Richard J, Paulus, Stephane, Jeffers, Graham, Williams, Kim, Breen, Rachel, Preston, Jennifer, Appelbe, Duncan, Chesters, Christine, Newland, Paul, Marzouk, Omnia, McNamara, Paul S, Diggle, Peter J and Carrol, Enitan D (2017). Predicting risk of serious bacterial infections in febrile children in the emergency department. Pediatrics, 140 (2) e20162853, e20162853. doi: 10.1542/peds.2016-2853
(2023–2026) The Children's Hospital Foundation
Pharmacogenomics for better treatment of fungal infections in cancer
(2023–2026) MRFF - National Critical Infrastructure Initiative
(2022–2023) Heidi-CSIRO IDR and AMR Projects
Gram-negative bloodstream infections in Australian children
Doctor Philosophy
The Burden of Extrapulmonary Tuberculosis in Africa
Doctor Philosophy
Expanding Data Sets to Allow Improved Critical Care for Children - Outpatient Risk Prediction
Doctor Philosophy
Wen, Sophie C. H., Ezure, Yukiko, Rolley, Lauren, Spurling, Geoff, Lau, Colleen L., Riaz, Saba, Paterson, David L. and Irwin, Adam D. (2021). Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis. PLoS Medicine, 18 (9) e1003787, 1-20. doi: 10.1371/journal.pmed.1003787
Channon-Wells, S., Kwok, M., Booth, J., Bamford, A., Konstanty, P., Hatcher, J., Dixon, G., Diggle, P. J., Standing, J. F. and Irwin, A. D. (2021). The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children. Journal of Antimicrobial Chemotherapy, 76 (9), 2464-2471. doi: 10.1093/jac/dkab187
Predicting risk of serious bacterial infections in febrile children in the emergency department
Irwin, Adam D, Grant, Alison, Williams, Rhian, Kolamunnage-Dona, Ruwanthi, Drew, Richard J, Paulus, Stephane, Jeffers, Graham, Williams, Kim, Breen, Rachel, Preston, Jennifer, Appelbe, Duncan, Chesters, Christine, Newland, Paul, Marzouk, Omnia, McNamara, Paul S, Diggle, Peter J and Carrol, Enitan D (2017). Predicting risk of serious bacterial infections in febrile children in the emergency department. Pediatrics, 140 (2) e20162853, e20162853. doi: 10.1542/peds.2016-2853
Hume, Jocelyn, Sweeney, Emma L., Lowry, Kym, Fraser, Chris, Clark, Julia E., Whiley, David M. and Irwin, Adam D. (2023). Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance. Frontiers in Pediatrics, 11. doi: 10.3389/fped.2023.1180392
Purcell, Rachael, Yeoh, Daniel, Bowen, Asha, Britton, Philip N., Carr, Jeremy P., Chen, Ming, Cheung, Kaman, Clark, Julia, Irwin, Adam, Lai, Tony, Lorenzen, Ulrik, Steer, Andrew, Wen, Sophie, Williams, Phoebe, Yap, Natalie, Cooper, Celia and Gwee, Amanda (2023). A multicentre, retrospective audit of fosfomycin use for urinary tract infections in Australian children and adolescents. Journal of Antimicrobial Chemotherapy, 1-6. doi: 10.1093/jac/dkad131
Ertl, Nicole G., Irwin, Adam D., Macdonald, Joanne, Bauer, Michelle J., Wang, Claire Y. T., Harris, Patrick N. A., Heney, Claire, Zowawi, Hosam M. and Whiley, David M. (2023). Rapid molecular detection of CMY-2, and CTX-M group 1 and 9 variants via recombinase polymerase amplification. JAC - Antimicrobial Resistance, 5 (2) dlad023, dlad023. doi: 10.1093/jacamr/dlad023
Davies, Mark R., Keller, Nadia, Brouwer, Stephan, Jespersen, Magnus G., Cork, Amanda J., Hayes, Andrew J., Pitt, Miranda E., De Oliveira, David M. P., Harbison-Price, Nichaela, Bertolla, Olivia M., Mediati, Daniel G., Curren, Bodie F., Taiaroa, George, Lacey, Jake A., Smith, Helen V., Fang, Ning-Xia, Coin, Lachlan J. M., Stevens, Kerrie, Tong, Steven Y. C., Sanderson-Smith, Martina, Tree, Jai J., Irwin, Adam D., Grimwood, Keith, Howden, Benjamin P., Jennison, Amy V. and Walker, Mark J. (2023). Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA. Nature Communications, 14 (1) 1051, 1-12. doi: 10.1038/s41467-023-36717-4
Schults, Jessica, Edwards, Felicity, Charles, Karina, Irwin, Adam D., Rickard, Claire M., Harris, Patrick N. A., Paterson, David L. and Laupland, Kevin (2023). Evolving insights into the epidemiology of Moraxella species bloodstream infection from two decades of surveillance in Queensland, Australia. European Journal of Clinical Microbiology and Infectious Diseases, 42 (2), 209-216. doi: 10.1007/s10096-022-04540-2
Gilholm, Patricia, Gibbons, Kristen, Lister, Paula, Harley, Amanda, Irwin, Adam, Raman, Sainath, Rice, Michael, Schlapbach, Luregn J. and Queensland Statewide Sepsis Collaborative (2023). Validation of a paediatric sepsis screening tool to identify children with sepsis in the emergency department: a statewide prospective cohort study in Queensland, Australia. BMJ Open, 13 (1) e061431, 1-25. doi: 10.1136/bmjopen-2022-061431
Nystatin is commonly prescribed as prophylaxis in children beyond the neonatal age
Jayawardena-Thabrew, Harshani, Warris, Adilia, PASOAP Group , Irwin, Adam and Ferreras-Antolin, Laura (2023). Nystatin is commonly prescribed as prophylaxis in children beyond the neonatal age. Medical Mycology, 61 (1) myac097. doi: 10.1093/mmy/myac097
Sharman, Leah S., Avent, Minyon L., Lyall, Vivian, Fejzic, Jasmina, Clark, Julia E., Irwin, Adam, Graham, Nicolette and van Driel, Mieke L. (2022). Improving paediatric antimicrobial stewardship in remote and regional Queensland hospitals: development and qualitative evaluation of a tailored intervention for intravenous-to-oral antibiotic switching. BMJ Open, 12 (12) e064888, 1-10. doi: 10.1136/bmjopen-2022-064888
Ayfan, Abdulrahman K. S., Macdonald, Joanne, Irwin, Adam D., Zowawi, Hosam M., Forde, Brian M., Paterson, David L., Lahra, Monica M. and Whiley, David M. (2022). Proof-of-concept, rapid, instrument-free molecular detection of Neisseria gonorrhoeae and ciprofloxacin susceptibility. Journal of Antimicrobial Chemotherapy, 77 (11), 2933-2936. doi: 10.1093/jac/dkac242
Blythe, Robin, Lister, Paula, Seaton, Robert, Harley, Amanda, Schlapbach, Luregn J., McPhail, Steven, Venkatesh, Bala, Irwin, Adam, Raman, Sainath, Schlapbach, Luregn, Harley, Amanda, Irwin, Adam, Graham, Nicolette, Thomson, Fiona, Owen, Kieran, Garrish, Kirsten, Sampson, Emma, Long, Debbie, George, Shane, Grimwood, Keith, Bell, Christa, Semple, Bethany, Adams, Claire, Brown, Josea, Maloney, Louise, Lister, Paula, Schofield, Scott, Thomas, Clare, Dejong, Liam ... the Queensland State-wide Sepsis Collaborative (2022). Patient and economic impact of implementing a paediatric sepsis pathway in emergency departments in Queensland, Australia. Scientific Reports, 12 (1) 10113, 10113. doi: 10.1038/s41598-022-14226-6
Avent, M.L., Lee, X.J., Irwin, A.D., Graham, N., Brain, D., Fejzic, J., van Driel, M. and Clark, J.E. (2022). An innovative Antimicrobial Stewardship Program for children in remote and regional areas in Queensland, Australia: optimizing antibiotic use through timely intravenous-to-oral conversion. Journal of Global Antimicrobial Resistance, 28, 53-58. doi: 10.1016/j.jgar.2021.11.014
Neonatal vascular access practice and complications : An observational study of 1,375 catheter days
McIntyre, Colette, August, Deanne, Cobbald, Linda, Lack, Gill, Takashima, Mari, Foxcroft, Katie, Marsh, Nicole, Smith, Patricia, New, Karen, Koorts, Pieter, Irwin, Adam and Ullman, Amanda (2022). Neonatal vascular access practice and complications : An observational study of 1,375 catheter days. Journal of Perinatal and Neonatal Nursing. doi: 10.1097/jpn.0000000000000589
Parker, Suzanne L., Irwin, Adam D., Hosking, Francine, August, Deanne, Schoenmaker, Brittany, Pandey, Saurabh, Wallis, Steven C., Lipman, Jeffrey, Roberts, Jason A. and Davies, Mark W. (2022). Innovation in microsampling for therapeutic drug monitoring of gentamicin in neonates: a proof-of-concept study. International Journal of Antimicrobial Agents, 59 (2) 106513, 1-2. doi: 10.1016/j.ijantimicag.2021.106513
Treatment of cutaneous leishmaniasis in a nonendemic country: a case series of children in Australia
Hill, Nicholas, Irwin, Adam, Graham, Nicolette, Leung, Clare, Francis, Joshua R, Wall, Nerilee and Nourse, Clare (2021). Treatment of cutaneous leishmaniasis in a nonendemic country: a case series of children in Australia. The Pediatric Infectious Disease Journal, Publish Ahead of Print (4), e177-e181. doi: 10.1097/inf.0000000000003445
The Paediatric AirWay Suction (PAWS) appropriateness guide for endotracheal suction interventions
Schults, Jessica, Charles, Karina, Long, Debbie, Brown, Georgia, Copnell, Beverley, Dargaville, Peter, Davies, Kylie, Erikson, Simon, Forrest, Kate, Harnischfeger, Jane, Irwin, Adam, Kendrik, Tina, Lake, Anna, Ntoumenopoulos, George, Waak, Michaela, Woodard, Mark, Tume, Lyvonne, Cooke, Marie, Mitchell, Marion, Hall, Lisa and Ullman, Amanda (2021). The Paediatric AirWay Suction (PAWS) appropriateness guide for endotracheal suction interventions. Australian Critical Care, 35 (6), 651-660. doi: 10.1016/j.aucc.2021.10.005
Raman, Sainath, English, Alana, O'Keefe, Meagan, Harley, Amanda, Steele, Mary, Minogue, Jess, Weller, Kate, Long, Debbie, Irwin, Adam and Lister, Paula (2021). Designing support structures post sepsis in children: perspectives of the Queensland Paediatric Sepsis Program. Frontiers in Pediatrics, 9 759234, 759234. doi: 10.3389/fped.2021.759234
Ferreras-Antolín, Laura, Irwin, Adam, Atra, Ayad, Chapelle, Faye, Drysdale, Simon B., Emonts, Marieke, McMaster, Paddy, Paulus, Stephane, Patel, Sanjay, Rompola, Menie, Vergnano, Stefania, Whittaker, Elizabeth and Warris, Adilia (2021). Pediatric antifungal prescribing patterns identify significant opportunities to rationalize antifungal use in children. The Pediatric Infectious Disease Journal, Publish Ahead of Print (3), e69-e74. doi: 10.1097/INF.0000000000003402
Venkatesh, Balasubramanian, Schlapbach, Luregn, Mason, Donna, Wilks, Kathryn, Seaton, Robert, Lister, Paula, Irwin, Adam, Lane, Paul, Redpath, Lyndell, Gibbons, Kristen, Ergetu, Endrias and Rice, Michael (2021). Impact of 1-hour and 3-hour sepsis time bundles on patient outcomes and antimicrobial use: a before and after cohort study. The Lancet Regional Health - Western Pacific, 18 100305, 100305. doi: 10.1016/j.lanwpc.2021.100305
Harley, Amanda, Lister, Paula, Gilholm, Patricia, Rice, Michael, Venkatesh, Bala, Johnston, Amy N.B., Massey, Debbie, Irwin, Adam, Gibbons, Kristen and Schlapbach, Luregn J. (2021). Queensland Pediatric Sepsis Breakthrough Collaborative: Multicenter Observational Study to Evaluate the Implementation of a Pediatric Sepsis Pathway Within the Emergency Department. Critical Care Explorations, 3 (11) e0573, 1-14. doi: 10.1097/cce.0000000000000573
Dinsmore, Nicole, McRae, Jocelynne E., Quinn, Helen E., Glover, Catherine, Dougherty, Sonia, McMinn, Allissa, Crawford, Nigel, Marshall, Helen, Carlson, Samantha J, Blyth, Christopher, Lucas, Ryan, Irwin, Adam, Macartney, Kristine, Britton, Philip N, Wood, Nicholas and The Paediatric Active Enhanced Disease Surveillance network (2021). Paediatric Active Enhanced Disease Surveillance (PAEDS) 2019: Prospective hospital-based surveillance for serious paediatric conditions. Communicable Diseases Intelligence, 45, 1-24. doi: 10.33321/cdi.2021.45.53
Wen, Sophie C. H., Ezure, Yukiko, Rolley, Lauren, Spurling, Geoff, Lau, Colleen L., Riaz, Saba, Paterson, David L. and Irwin, Adam D. (2021). Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis. PLoS Medicine, 18 (9) e1003787, 1-20. doi: 10.1371/journal.pmed.1003787
MicroPIPE: validating an end-to-end workflow for high-quality complete bacterial genome construction
Murigneux, Valentine, Roberts, Leah W., Forde, Brian M., Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Irwin, Adam D., Harris, Patrick N. A., Paterson, David L., Schembri, Mark A., Whiley, David M. and Beatson, Scott A. (2021). MicroPIPE: validating an end-to-end workflow for high-quality complete bacterial genome construction. BMC Genomics, 22 (1) 474, 474. doi: 10.1186/s12864-021-07767-z
Irwin, Adam D., Coin, Lachlan J. M., Harris, Patrick N. A., Cotta, Menino Osbert, Bauer, Michelle J., Buckley, Cameron, Balch, Ross, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Beatson, Scott A., Forde, Brian M., Paterson, David, Clark, Julia, Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Schlapbach, Luregn J. and Roberts, Jason A. (2021). Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT). Frontiers in Cellular and Infection Microbiology, 11 667680, 1-8. doi: 10.3389/fcimb.2021.667680
Peri, Anna Maria, Stewart, Adam, Hume, Anna, Irwin, Adam and Harris, Patrick N A (2021). New microbiological techniques for the diagnosis of bacterial infections and sepsis in ICU including point of care. Current Infectious Disease Reports, 23 (8) 12, 12. doi: 10.1007/s11908-021-00755-0
Pérez-López, Andrés, Irwin, Adam, Rodrigo, Carlos and Prat-Aymerich, Cristina (2021). Role of C reactive protein and procalcitonin in the diagnosis of lower respiratory tract infection in children in the outpatient setting. BMJ, 373 (11) n1409, n1409. doi: 10.1136/bmj.n1409
Channon-Wells, S., Kwok, M., Booth, J., Bamford, A., Konstanty, P., Hatcher, J., Dixon, G., Diggle, P. J., Standing, J. F. and Irwin, A. D. (2021). The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children. Journal of Antimicrobial Chemotherapy, 76 (9), 2464-2471. doi: 10.1093/jac/dkab187
Schults, Jessica A., Cooke, Marie, Long, Debbie, Schibler, Andreas, Ware, Robert S., Charles, Karina, Irwin, Adam and Mitchell, Marion L. (2021). Normal saline and lung recruitment with paediatric endotracheal suction (NARES): a pilot, factorial, randomised controlled trial. Australian Critical Care, 34 (6), 530-538. doi: 10.1016/j.aucc.2021.01.006
Ayfan, Abdulrahman K. S., Macdonald, Joanne, Harris, Patrick N. A., Heney, Claire, Paterson, David L., Trembizki, Ella, Wang, Claire Y. T., Whiley, David M., Zowawi, Hosam M. and Irwin, Adam D. (2021). Rapid detection of NDM and VIM carbapenemase encoding genes by recombinase polymerase amplification and lateral flow–based detection. European Journal of Clinical Microbiology & Infectious Diseases, 40 (11), 2447-2453. doi: 10.1007/s10096-021-04267-6
Wen, Sophie C.H., Ezure, Yukiko, Rolley, Lauren, Spurling, Geoff, Lau, Colleen L., Paterson, David L. and Irwin, Adam D. (2021). Gram-Negative Neonatal Sepsis in Low- and Middle- Income Countries: How Appropriate are the WHO Recommended Empirical Sepsis Antibiotic Regimens? A Systematic Review and Meta-Analysis. SSRN Electronic Journal. doi: 10.2139/ssrn.3777180
The relevance of probiotics in Caesarean-born neonates
Sidjabat, Hanna E., Alsaggaf, Alaa Mohammed Ali, Gopalakrishna, Akshatha, Nadar, Evelyn, Irwin, Adam and Koorts, Pieter (2020). The relevance of probiotics in Caesarean-born neonates. Microbiology Australia, 41 (2), 75-81. doi: 10.1071/ma20020
Warris, Adilia, Pana, Zoi-Dorothea, Oletto, Andrea, Lundin, Rebecca, Castagnola, Elio, Lehrnbecher, Thomas, Groll, Andreas H., Roilides, Emmanuel, Andersen, Cecilie T., Arendrup, Maiken C., Arsenijevic, Valentina Arsic, Bianchini, Sonia, von Both, Ulrich, Chmelnik, Martin, Controzzi, Tiziana, Emonts, Marieke, Esposito, Susanna, Ferreras-Antolin, Laura, Henriet, Stefanie, Iosifidis, Elias, Irwin, Adam, Kopsidas, John, Lagrou, Katrien, Lyall, Hermione, Casteleiro, Angela Manzanares, Mesini, Alessio, Olbrich, Peter, Paulus, Stephane, Lausch, Karen Rokkedal ... EUROCANDY Study Group (2019). Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study. The Pediatric Infectious Disease Journal, 39 (2), 1-120. doi: 10.1097/INF.0000000000002530
Ferreras-Antolín, Laura, Irwin, Adam, Atra, Ayad, Dermirjian, Alicia, Drysdale, Simon B, Emonts, Marieke, McMaster, Paddy, Paulus, Stephane, Patel, Sanjay, Kinsey, Sally, Vergnano, Stefania, Whittaker, Elisabeth and Warris, Adilia (2019). Neonatal Antifungal Consumption Is Dominated by Prophylactic Use; Outcomes From The Pediatric Antifungal Stewardship: Optimizing Antifungal Prescription Study. The Pediatric infectious disease journal, 38 (12), 1-1223. doi: 10.1097/INF.0000000000002463
Lynn, Richard M, Reading, Richard, BPSU Ascertainment Group and Irwin, Adam (2019). Case ascertainment in active paediatric surveillance systems: a report from the British Paediatric Surveillance Unit Ascertainment Group. Archives of disease in childhood, 105 (1), 62-68. doi: 10.1136/archdischild-2019-317401
Hsia, Yingfen, Lee, Brian R., Versporten, Ann, Yang, Yonghong, Bielicki, Julia, Jackson, Charlotte, Newland, Jason, Goossens, Herman, Magrini, Nicola, Sharland, Mike, Teston, L., Cheung, K., Koning, S., Grimwood, K., Cross, J., da Silva, A., Benadof, D., Zhang, W. S., Zhao, W., Liu, G., Shen, K. L., Yao, K. H., Zheng, Y. J., Deng, J. K., Zhang, J. S., Wang, Y., Jiang, X. Y., Tian, D. Y., Jing, C. M. ... Gawrys, G. (2019). Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries. The Lancet Global Health, 7 (7), E861-E871. doi: 10.1016/S2214-109X(19)30071-3
Kloprogge, Frank, Hill, Louise, Booth, John, Klein, Nigel, Irwin, Adam, Dixon, Garth and Standing, Joseph F (2019). Revising paediatric vancomycin dosing accounting for nephrotoxicity in a pharmacokinetic-pharmacodynamic model. Antimicrobial Agents and Chemotherapy, 63 (5) e00067-19. doi: 10.1128/aac.00067-19
Detection of epidemic scarlet fever group A Streptococcus in Australia
Walker, Mark J., Brouwer, Stephan, Forde, Brian M., Worthing, Kate A., McIntyre, Liam, Sundac, Lana, Maloney, Sam, Roberts, Leah W., Barnett, Timothy C., Richter, Johanna, Cork, Amanda J., Irwin, Adam D., You, Yuanhai, Zhang, Jianzhong, Dougan, Gordon, Yuen, K. Y., Nizet, Victor, Beatson, Scott A., Grimwood, Keith and Davies, Mark R. (2019). Detection of epidemic scarlet fever group A Streptococcus in Australia. Clinical Infectious Diseases, 69 (7), 1232-1234. doi: 10.1093/cid/ciz099
Johnson, S. M., Standing, J. F., Klein, N., Irwin, A. D., Shingadia, D., Lonsdale, D. O., Gilmour, K. C., Flynn, J., Manns, C., Clapson, M. and Bamford, A. (2019). A case for reduced frequency of CD4 count monitoring for children on combination antiretroviral therapy with consistently undetectable HIV viral load. HIV Medicine, 20 (4), e8-e9. doi: 10.1111/hiv.12706
Boonsathorn, Sophida, Cheng, Iek, Kloprogge, Frank, Alonso, Carlos, Lee, Charmion, Doncheva, Bilyana, Booth, John, Chiesa, Robert, Irwin, Adam and Standing, Joseph F. (2019). Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children (vol 58, pg 53, 2019). Clinical Pharmacokinetics, 58 (1), 141-141. doi: 10.1007/s40262-018-0722-x
Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children
Boonsathorn, Sophida, Cheng, Iek, Kloprogge, Frank, Alonso, Carlos, Lee, Charmion, Doncheva, Bilyana, Booth, John, Chiesa, Robert, Irwin, Adam and Standing, Joseph F. (2018). Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children. Clinical Pharmacokinetics, 58 (1), 1-9. doi: 10.1007/s40262-018-0658-1
Question 2: are three malaria tests necessary in children returning from the tropics with fever?
Wilson, Isabel Emily, Shingadia, Delane, Yeung, Shunmay, Riordan, Andrew and Irwin, Adam David (2018). Question 2: are three malaria tests necessary in children returning from the tropics with fever?. Archives of Disease in Childhood, 103 (1), 109-112. doi: 10.1136/archdischild-2017-313843
Predicting risk of serious bacterial infections in febrile children in the emergency department
Irwin, Adam D, Grant, Alison, Williams, Rhian, Kolamunnage-Dona, Ruwanthi, Drew, Richard J, Paulus, Stephane, Jeffers, Graham, Williams, Kim, Breen, Rachel, Preston, Jennifer, Appelbe, Duncan, Chesters, Christine, Newland, Paul, Marzouk, Omnia, McNamara, Paul S, Diggle, Peter J and Carrol, Enitan D (2017). Predicting risk of serious bacterial infections in febrile children in the emergency department. Pediatrics, 140 (2) e20162853, e20162853. doi: 10.1542/peds.2016-2853
Acute infectious hepatitis in hospitalised children: a British Paediatric Surveillance Unit study
Braccio, Serena, Irwin, Adam, Riordan, Andrew, Shingadia, Delane, Kelly, Deirdre A., Bansal, Sanjay, Ramsay, Mary and Ladhani, Shamez N. (2017). Acute infectious hepatitis in hospitalised children: a British Paediatric Surveillance Unit study. Archives of Disease in Childhood, 102 (7), 624-628. doi: 10.1136/archdischild-2016-311916
Bustinduy, Amaya L., Chis Ster, Irina, Shaw, Rebecca, Irwin, Adam, Thiagarajan, Jaiganesh, Beynon, Rhys, Ladhani, Shamez, Sharland, Mike and CABIN network (2017). Predictors of fever-related admissions to a paediatric assessment unit, ward and reattendances in a South London emergency department: the CABIN 2 study. Archives of Disease in Childhood, 102 (1), 22-28. doi: 10.1136/archdischild-2016-310494
Irwin, A. D., Wickenden, J., Le Doare, K., Ladhani, S. and Sharland, M. (2016). Supporting decisions to increase the safe discharge of children with febrile illness from the emergency department: a systematic review and meta-analysis. e ADC, 101 (3), 259-66. doi: 10.1136/archdischild-2015-309056
Wells, Rosy, Le Doare, Kirsty, Sharland, Mike, Heath, Paul, Ladhani, Shamez N, CABIN Network and Irwin, Adam (2015). Targeted empiric antibiotic therapy for children with non-oncological comorbidities and community-onset invasive bacterial infections. The Journal of Infection, 71 (3), 294-301. doi: 10.1016/j.jinf.2015.05.002
Etiology of childhood bacteremia and timely antibiotics administration in the emergency department
Irwin, Adam D., Drew, Richard J., Marshall, Philippa, Nguyen, Kha, Hoyle, Emily, Macfarlane, Kate A., Wong, Hoying F., Mekonnen, Ellen, Hicks, Matthew, Steele, Tom, Gerrard, Christine, Hardiman, Fiona, McNamara, Paul S., Diggle, Peter J. and Carrol, Enitan D. (2015). Etiology of childhood bacteremia and timely antibiotics administration in the emergency department. Pediatrics, 135 (4), 635-642. doi: 10.1542/peds.2014-2061
Improving antibiotic prescribing for children in the resource-poor setting
Le Doare, Kirsty, Barker, Charlotte I. S., Irwin, Adam and Sharland, Mike (2015). Improving antibiotic prescribing for children in the resource-poor setting. British Journal of Clinical Pharmacology, 79 (3), 446-455. doi: 10.1111/bcp.12320
Sabhaney, Vikram, Enarson, Paul, Irwin, Adam D., Carrol, Enitan D., Schuetz, Philipp, Briel, Matthias, Bucher, Heiner C. and Mueller, Beat (2013). Commentaries on ‘Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections’ with a response from the review authors. Evidence-Based Child Health, 8 (4), 1372-1375. doi: 10.1002/ebch.1928
Irwin, Adam and Sharland, Mike (2013). Measuring antibiotic prescribing in hospitalised children in resource-poor countries: a systematic review. Journal of Paediatrics and Child Health, 49 (3), 185-192. doi: 10.1111/j.1440-1754.2011.02126.x
Irwin, Adam D., Marriage, Fiona, Mankhambo, Limangeni A., Jeffers, Graham, Kolamunnage-Dona, Ruwanthi, Guiver, Malcolm, Denis, Brigitte, Molyneux, Elizabeth M., Molyneux, Malcolm E., Day, Philip J. and Carrol, Enitan D. (2012). Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children. BMC Medical Genomics, 5 (1) 13. doi: 10.1186/1755-8794-5-13
Irwin, Adam D. and Carrol, Enitan D. (2011). Procalcitonin. Archives of Disease in Childhood-Education and Practice Edition, 96 (6), 228-233. doi: 10.1136/archdischild-2011-300178
Predicting a patient's choice of dialysis modality: experience in a United Kingdom renal department
Little, Jane, Irwin, Adam, Marshall, Tim, Rayner, Hugh and Smith, Stephen (2001). Predicting a patient's choice of dialysis modality: experience in a United Kingdom renal department. American Journal of Kidney Diseases, 37 (5), 981-986. doi: 10.1016/S0272-6386(05)80014-9
Gilholm, P., Irwin, A., Lister, P., Harley, A., Raman, S., Schlapbach, L. J. and Gibbons, K. (2022). Identifying clinical symptom profiles for sepsis in children screened for sepsis on admission to the emergency department. 11th Congress of the World Federation of Pediatric Intensive & Critical Care Societies, Online, 12-16 July 2022. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.pcc.0000899876.46317.ec
Schults, Jessica, Charles, Karina, Long, Debbie, Erikson, Simon, Irwin, Adam, Waak, Michaela, Hall, Lisa and Ullman, Amanda (2021). Recommendations for endotracheal suction interventions in children with highly infectious respiratory disease: results from a RAND/UCLA binational appropriateness panel. 9th International Australasian College for Infection Prevention and Control (ACIPC) online conference, Online, 7-10 November 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.idh.2021.09.031
Ayfan, A., Ertl, N., Whiley, D., Paterson, D., Heney, C., Harris, P., Macdonald, J., Irwin, A. and Zowawi, H. (2020). Rapid and sensitive molecular detection of antimicrobial resistance (AMR); towards point-of-care testing in low resource settings. GCCMID 2019, Dubai, United Arab Emirates, 6-9 November 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jiph.2020.01.059
Neonatal observational vascular access (NOVA): an Australian audit
August, Deanne, Ullman, Amanda, New, Karen, McIntyre, Colette, Smith, Patricia, Koorts, Pieter, Irwin, Adam, Cobbald, Linda, Lack, Gill, Takashima, Mari, Foxcroft, Katie and Marsh, Nicole (2019). Neonatal observational vascular access (NOVA): an Australian audit. 3rd Congress of Joint European Neonatal Societies (jENS), Masstricht, Netherlands, 17-21 September 2019. New York, United States: Nature Publishing Group.
Kwok, M., Booth, J., Konstanty, P., Standing, J.F. and Irwin, A.D. (2017). A2.1 A comparison of metrics to evaluate trends in antimicrobial consumption in a tertiary children’s hospital. Great Ormond Street Hospital Conference, Nottingham, United Kingdom, 21–22 June, 2017. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/archdischild-2017-084620.21
(2023–2026) The Children's Hospital Foundation
Pharmacogenomics for better treatment of fungal infections in cancer
(2023–2026) MRFF - National Critical Infrastructure Initiative
(2022–2023) Heidi-CSIRO IDR and AMR Projects
ARC Training Centre for Information Resilience
(2021–2026) ARC Industrial Transformation Training Centres
(2021–2025) NHMRC Investigator Grants
(2021–2025) Cancer Council Queensland
(2021–2022) The Children's Hospital Foundation
(2020–2023) The Children's Hospital Foundation
(2020–2021) NHMRC MRFF Coronavirus Research Response
(2020–2021) The Children's Hospital Foundation
Rapid point-of-care tests for multidrug resistant bacteria tailored for QLD paediatrics
(2019–2021) The Children's Hospital Foundation
Virulence and detection of Escherichia coli that cause neonatal meningitis
(2019–2021) The Children's Hospital Foundation
(2019–2020) Metro North Hospital and Health Service
(2018–2020) The Children's Hospital Foundation
Sakzewski Core Translational Research Group
(2018–2019) The Children's Hospital Foundation
Gram-negative bloodstream infections in Australian children
Doctor Philosophy — Principal Advisor
Other advisors:
The Burden of Extrapulmonary Tuberculosis in Africa
Doctor Philosophy — Associate Advisor
Other advisors:
Expanding Data Sets to Allow Improved Critical Care for Children - Outpatient Risk Prediction
Doctor Philosophy — Associate Advisor
Other advisors:
The development of an integrated molecular diagnostic pathway to optimise the treatment of cytomegalovirus in children undergoing haematopoietic stem cell transplant
Doctor Philosophy — Associate Advisor
Other advisors:
Improving Sepsis Management through Better Data and Rapid Learning
Doctor Philosophy — Associate Advisor
Other advisors: