Sourris, Karly C., Ding, Yi, Maxwell, Scott S., Al-sharea, Annas, Kantharidis, Phillip, Mohan, Muthukumar, Rosado, Carlos J., Penfold, Sally A., Haase, Claus, Xu, Yangsong, Forbes, Josephine M., Crawford, Simon, Ramm, Georg, Harcourt, Brooke E., Jandeleit-Dahm, Karin, Advani, Andrew, Murphy, Andrew J., Timmermann, Daniel B., Karihaloo, Anil, Knudsen, Lotte Bjerre, El-Osta, Assam, Drucker, Daniel J., Cooper, Mark E. and Coughlan, Melinda T. (2023). Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation. Kidney International, 105 (1), 132-149. doi: 10.1016/j.kint.2023.09.029
Journal Article: Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes
Leung, Sherman S., Lenchik, Nataliya, Mathews, Clayton, Pugliese, Alberto, McCarthy, Domenica A., Le Bagge, Selena, Ewing, Adam, Harris, Mark, Radford, Kristen J., Borg, Danielle J., Gerling, Ivan and Forbes, Josephine M. (2023). Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes. Scientific Reports, 13 (1) 12948, 1-15. doi: 10.1038/s41598-023-39243-x
Conference Publication: Hypoxia and interleukin (IL)-1β synergistically induce cellular senescence in human proximal tubular epithelial cells (PTEC)
Kassianos, Andrew J., Giuliani, Kurt, Nag, Purba, Hong, Seokchan, Wang, Xiangju, Johnston, Rebecca L., Adams, Benjamin, Grivei, Anca, Ho, Kenneth, Ng, Monica, Waddell, Nicola, Forbes, Josephine M., Healy, Helen and Kassianos, Andrew J. (2023). Hypoxia and interleukin (IL)-1β synergistically induce cellular senescence in human proximal tubular epithelial cells (PTEC). 58th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Christchurch, New Zealand, 4-6 September 2023. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14216
Designing and translating novel therapies for diabetes and kidney disease
(2022–2026) NHMRC Investigator Grants
Innovative delivery methods for the biologic soluble RAGE to prevent Type 1 Diabetes
(2021–2024) JDRF Pilot and Innovation Awards
Preventing progression of diabetic kidney disease by targeting mitochondrial function
(2019–2021) NHMRC Project Grant
Early mitochondrial dysfunction in diabetic kidney
Doctor Philosophy
The receptor for advanced glycation end products and its role in Type 1 diabetes development
Doctor Philosophy
New insights into molecular pathways involved in the development of diabetic kidney disease: Towards earlier disease detection and identification of novel therapeutic targets
Doctor Philosophy
Advanced glycation, diabetes, and dementia
Dhananjayan, Karthik, Forbes, Josephine and Münch, Gerald (2018). Advanced glycation, diabetes, and dementia. Type 2 diabetes and dementia. (pp. 169-193) edited by Velandai Srikanth and Zoe Arvanitakis. London, United Kingdom: Academic Press (Elsevier). doi: 10.1016/B978-0-12-809454-9.00009-3
Dietary AGEs in the development and progression of chronic kidney disease
Fotheringham, Amelia K., Gallo, Linda A. and Forbes, Josephine M. (2018). Dietary AGEs in the development and progression of chronic kidney disease. Dietary AGEs and their role in health and disease. (pp. 213-224) edited by Jaime Uribarri. Boca Raton, FI, United States: CRC Press. doi: 10.1201/9781315120041
Role of oxidative stress in diabetic nephropathy
Forbes, Josephine M., Coughlan, Melinda T. and Cooper, Mark E. (2011). Role of oxidative stress in diabetic nephropathy. Advances in Pathogenesis of Diabetic Nephropathy. (pp. 199-218) Nova Science Publishers, Inc..
Sourris, Karly C., Ding, Yi, Maxwell, Scott S., Al-sharea, Annas, Kantharidis, Phillip, Mohan, Muthukumar, Rosado, Carlos J., Penfold, Sally A., Haase, Claus, Xu, Yangsong, Forbes, Josephine M., Crawford, Simon, Ramm, Georg, Harcourt, Brooke E., Jandeleit-Dahm, Karin, Advani, Andrew, Murphy, Andrew J., Timmermann, Daniel B., Karihaloo, Anil, Knudsen, Lotte Bjerre, El-Osta, Assam, Drucker, Daniel J., Cooper, Mark E. and Coughlan, Melinda T. (2023). Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation. Kidney International, 105 (1), 132-149. doi: 10.1016/j.kint.2023.09.029
Leung, Sherman S., Lenchik, Nataliya, Mathews, Clayton, Pugliese, Alberto, McCarthy, Domenica A., Le Bagge, Selena, Ewing, Adam, Harris, Mark, Radford, Kristen J., Borg, Danielle J., Gerling, Ivan and Forbes, Josephine M. (2023). Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes. Scientific Reports, 13 (1) 12948, 1-15. doi: 10.1038/s41598-023-39243-x
RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice
Joshi, Aditi A., Wu, Ying, Deng, Songyan, Preston-Hurlburt, Paula, Forbes, Josephine M. and Herold, Kevan C. (2022). RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice. Clinical Immunology, 245 109165, 1-6. doi: 10.1016/j.clim.2022.109165
Advanced glycation end products and inflammation in type 1 diabetes development
Du, Chenping, Whiddett, Rani O., Buckle, Irina, Chen, Chen, Forbes, Josephine M. and Fotheringham, Amelia K. (2022). Advanced glycation end products and inflammation in type 1 diabetes development. Cells, 11 (21) 3503, 1-18. doi: 10.3390/cells11213503
Giuliani, Kurt T. K., Grivei, Anca, Nag, Purba, Wang, Xiangju, Rist, Melissa, Kildey, Katrina, Law, Becker, Ng, Monica S., Wilkinson, Ray, Ungerer, Jacobus, Forbes, Josephine M., Healy, Helen and Kassianos, Andrew J. (2022). Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c+ dendritic cells. Cell Death and Disease, 13 (8) 739, 1-13. doi: 10.1038/s41419-022-05191-z
Mitochondrial dysfunction in individuals with diabetic kidney disease: a systematic review
Flemming, Nicole, Pernoud, Laura, Forbes, Josephine and Gallo, Linda (2022). Mitochondrial dysfunction in individuals with diabetic kidney disease: a systematic review. Cells, 11 (16) 2481, 1-24. doi: 10.3390/cells11162481
Fotheringham, Amelia K., Gallo, Linda A., Borg, Danielle J. and Forbes, Josephine M. (2022). Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?. Nutrients, 14 (13) 2675, 1-28. doi: 10.3390/nu14132675
Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells
Leung, Sherman S., Borg, Danielle J., McCarthy, Domenica A., Boursalian, Tamar E., Cracraft, Justen, Zhuang, Aowen, Fotheringham, Amelia K., Flemming, Nicole, Watkins, Thomas, Miles, John J., Groop, Per-Henrik, Scheijen, Jean L., Schalkwijk, Casper G., Steptoe, Raymond J., Radford, Kristen J., Knip, Mikael and Forbes, Josephine M. (2022). Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells. Diabetes, 71 (9), 1994-2008. doi: 10.2337/db22-0177
Doola, Ra'eesa, Deane, Adam M., Barrett, Helen L., Okano, Satomi, Tolcher, Debbie M., Gregory, Kye, Coombes, Jeff S., Schalkwijk, Casper, Todd, Alwyn S., Forbes, Josephine M. and Sturgess, David J. (2022). The impact of a modified carbohydrate formula, and its constituents, on glycaemic control and inflammatory markers: a nested mechanistic sub-study. Journal of Human Nutrition and Dietetics, 35 (3), 455-465. doi: 10.1111/jhn.12959
Fotheringham, Amelia K., Solon-Biet, Samantha M., Bielefeldt-Ohmann, Helle, McCarthy, Domenica A., McMahon, Aisling C., Ruohonen, Kari, Li, Isaac, Sullivan, Mitchell A., Whiddett, Rani O., Borg, Danielle J., Cogger, Victoria C., Ballard, William O., Turner, Nigel, Melvin, Richard G., Raubenheimer, David, Le Couteur, David G., Simpson, Stephen J. and Forbes, Josephine M. (2021). Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 24 (11) 103308, 103308. doi: 10.1016/j.isci.2021.103308
Forbes, Josephine M., McCarthy, Domenica A., Kassianos, Andrew J., Baskerville, Tracey, Fotheringham, Amelia J., Giuliani, Kurt T. K., Grivei, Anca, Murphy, Andrew J., Flynn, Michelle C., Sullivan, Mitchell A., Chandrashekar, Preeti, Whiddett, Rani, Radford, Kristen J., Flemming, Nicole, Beard, Sam S., D’Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasdale, Stephanie, Russell, Anthony, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Healy, Helen, Harris, Mark, Donaghue, Kim, Johnson, David W., Cotterill, Andrew, Barrett, Helen L. and O’Moore-Sullivan, Trisha (2021). T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes. Diabetes, 70 (8), 1754-1766. doi: 10.2337/db20-1081
Borg, Danielle J., Faridi, Pouya, Giam, Kai Lin, Reeves, Peta, Fotheringham, Amelia K., McCarthy, Domenica A., Leung, Sherman, Ward, Micheal S., Harcourt, Brooke E., Ayala, Rochelle, Scheijen, Jean L., Briskey, David, Dudek, Nadine L., Schalkwijk, Casper G., Steptoe, Raymond, Purcell, Anthony W. and Forbes, Josephine M. (2021). Short duration alagebrium chloride therapy prediabetes does not inhibit progression to autoimmune diabetes in an experimental model. Metabolites, 11 (7) 426, 1-21. doi: 10.3390/metabo11070426
Advanced glycation end products as predictors of renal function in youth with type 1 diabetes
Forbes, Josephine M., Le Bagge, Selena, Righi, Samuel, Fotheringham, Amelia K., Gallo, Linda A., McCarthy, Domenica A., Leung, Sherman, Baskerville, Tracey, Nisbett, Janelle, Morton, Adam, Teasdale, Stephanie, D'Silva, Neisha, Barrett, Helen, Jones, Timothy, Couper, Jennifer, Donaghue, Kim, Isbel, Nicole, Johnson, David W., Donnellan, Leigh, Deo, Permal, Akison, Lisa K., Moritz, Karen M. and O'Moore-Sullivan, Trisha (2021). Advanced glycation end products as predictors of renal function in youth with type 1 diabetes. Scientific Reports, 11 (1) 9422, 9422. doi: 10.1038/s41598-021-88786-4
Snelson, Matthew, Clarke, Rachel Elise, Nguyen, Tuong-Vi, Penfold, Sally Anne, Forbes, Josephine Maree, Tan, Sih Min and Coughlan, Melinda Therese (2021). Long term high protein diet feeding alters the microbiome and increases intestinal permeability, systemic inflammation and kidney injury in mice. Molecular Nutrition and Food Research, 65 (8) 2000851, 1-12. doi: 10.1002/mnfr.202000851
Processed foods drive intestinal barrier permeability and microvascular diseases
Snelson, Matthew, Tan, Sih Min, Clarke, Rachel E., De Pasquale, Cassandra, Thallas-Bonke, Vicki, Nguyen, Tuong-Vi, Penfold, Sally A., Harcourt, Brooke E., Sourris, Karly C., Lindblom, Runa S., Ziemann, Mark, Steer, David, El-Osta, Assam, Davies, Michael J., Donnellan, Leigh, Deo, Permal, Kellow, Nicole J., Cooper, Mark E., Woodruff, Trent M., Mackay, Charles R., Forbes, Josephine M. and Coughlan, Melinda T. (2021). Processed foods drive intestinal barrier permeability and microvascular diseases. Science Advances, 7 (14) eabe4841, 1-16. doi: 10.1126/sciadv.abe4841
Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health
Wali, Jibran A., Milner, Annabelle J., Luk, Alison W. S., Pulpitel, Tamara J., Dodgson, Tim, Facey, Harrison J. W., Wahl, Devin, Kebede, Melkam A., Senior, Alistair M., Sullivan, Mitchell A., Brandon, Amanda E., Yau, Belinda, Lockwood, Glen P., Koay, Yen Chin, Ribeiro, Rosilene, Solon-Biet, Samantha M., Bell-Anderson, Kim S., O’Sullivan, John F., Macia, Laurence, Forbes, Josephine M., Cooney, Gregory J., Cogger, Victoria C., Holmes, Andrew, Raubenheimer, David, Le Couteur, David G. and Simpson, Stephen J. (2021). Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Nature Metabolism, 3 (6), 810-828. doi: 10.1038/s42255-021-00393-9
Zhuang, Aowen, Yap, Felicia Y. T., Borg, Danielle J., McCarthy, Domenica, Fotheringham, Amelia, Leung, Sherman, Penfold, Sally A., Sourris, Karly C., Coughlan, Melinda T., Schulz, Benjamin L. and Forbes, Josephine M. (2021). The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition). Endocrinology, Diabetes and Metabolism, 4 (3) e00278, e00278. doi: 10.1002/edm2.278
Going in early: hypoxia as a target for kidney disease prevention in diabetes?
Barrett, Helen L., Donaghue, Kim C. and Forbes, Josephine M. (2020). Going in early: hypoxia as a target for kidney disease prevention in diabetes?. Diabetes, 69 (12), 2578-2580. doi: 10.2337/dbi20-0037
Fotheringham, Amelia K., Bagger, Jonatan I., Borg, Danielle J., McCarthy, Domenica A., Holst, Jens J., Vilsbøll, Tina, Knop, Filip K. and Forbes, Josephine M. (2020). Circulating levels of the soluble receptor for AGE (sRAGE) during escalating oral glucose dosages and corresponding isoglycaemic i.v. glucose infusions in individuals with and without type 2 diabetes. Nutrients, 12 (10) 2928, 2928-12. doi: 10.3390/nu12102928
Transient intermittent hyperglycemia accelerates atherosclerosis by promoting myelopoiesis
Flynn, Michelle C., Kraakman, Michael J., Tikellis, Christos, Lee, Man Ks, Hanssen, Nordin Mj, Kammoun, Helene L., Pickering, Raelene, Dragoljevic, Dragana, Al-Sharea, Annas, Barrett, Tessa J., Hortle, Fiona, Byrne, Frances L., Olzomer, Ellen, McCarthy, Domenica A., Schalkwijk, Casper G., Forbes, Josephine M., Hoehn, Kyle, Makowski, Liza, Lancaster, Graeme I., El-Osta, Assam, Fisher, Edward A., Goldberg, Ira J., Cooper, Mark E., Nagareddy, Prabhakara R., Thomas, Merlin C. and Murphy, Andrew J. (2020). Transient intermittent hyperglycemia accelerates atherosclerosis by promoting myelopoiesis. Circulation Research, 127 (7) CIRCRESAHA.120.316653, 877-892. doi: 10.1161/CIRCRESAHA.120.316653
Prolyl hydroxylase inhibitors: a breath of fresh air for diabetic kidney disease?
Forbes, Josephine M. (2020). Prolyl hydroxylase inhibitors: a breath of fresh air for diabetic kidney disease?. Kidney International, 97 (5), 855-857. doi: 10.1016/j.kint.2020.01.038
Khan, Tashbib, He, Yaowu, Kryza, Thomas, Harrington, Brittney S., Gunter, Jennifer H., Sullivan, Mitchell A., Cuda, Tahleesa, Rogers, Rebecca, Davies, Claire M., Broomfield, Amy, Gough, Madeline, Wu, Andy C., McGann, Thomas, Weroha, S. John, Haluska, Paul, Forbes, Josephine M., Armes, Jane E., Barry, Sinead C., Coward, Jermaine I., Jagasia, Nisha, Chetty, Naven, Snell, Cameron E., Lourie, Rohan, Perrin, Lewis C. and Hooper, John D. (2020). Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma. Cancers, 12 (4) 869, 869. doi: 10.3390/cancers12040869
Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes
Le Bagge, Selena, Fotheringham, Amelia K., Leung, Sherman S. and Forbes, Josephine M. (2020). Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes. Medicinal Research Reviews, 40 (4) med.21654, 1200-1219. doi: 10.1002/med.21654
Lindblom, Runa S. J., Higgins, Gavin C., Nguyen, Tuong-Vi, Arnstein, Maryann, Henstridge, Darren C., Granata, Cesare, Snelson, Matthew, Thallas-Bonke, Vicki, Cooper, Mark E., Forbes, Josephine M. and Coughlan, Melinda T. (2020). Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D. Clinical Science, 134 (2), 239-259. doi: 10.1042/CS20190787
Tan, Sih Min, Ziemann, Mark, Thallas-Bonke, Vicki, Snelson, Matthew, Kumar, Vinod, Laskowski, Adrienne, Nguyen, Tuong-Vi, Huynh, Kevin, Clarke, Michele V., Libianto, Renata, Baker, Scott T., Skene, Alison, Power, David A., MacIsaac, Richard J., Henstridge, Darren C., Wetsel, Rick A., El-Osta, Assam, Meikle, Peter J., Wilson, Scott G., Forbes, Josephine M., Cooper, Mark E., Ekinci, Elif I., Woodruff, Trent M. and Coughlan, Melinda T. (2019). Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility. Diabetes, 69 (1), 83-98. doi: 10.2337/db19-0043
Fernando, Dinali H., Forbes, Josephine M., Angus, Peter W. and Herath, Chandana B. (2019). Development and progression of non-alcoholic fatty liver disease: the role of advanced glycation end products. International Journal of Molecular Sciences, 20 (20) 5037, 5037. doi: 10.3390/ijms20205037
Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease
Balmer, Lois A., Whiting, Rhiannon, Rudnicka, Caroline, Gallo, Linda A., Jandeleit, Karin A., Chow, Yan, Chow, Z., Richardson, Kirsty L., Forbes, Josephine M. and Morahan, G. (2019). Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease. Kidney International, 96 (4), 918-926. doi: 10.1016/j.kint.2019.04.031
Zhuang, Aowen, Yap, Felicia Y. T., McCarthy, Domenica, Leung, Chris, Sourris, Karly C., Penfold, Sally A., Thallas-Bonke, Vicki, Coughlan, Melinda T., Schulz, Benjamin L. and Forbes, Josephine M. (2019). Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion. Scientific Reports, 9 (1) 13664, 13664. doi: 10.1038/s41598-019-50221-0
Glucose and glycogen in the diabetic kidney: heroes or villains?
Sullivan, Mitchell A. and Forbes, Josephine M. (2019). Glucose and glycogen in the diabetic kidney: heroes or villains?. EBioMedicine, 47, 590-597. doi: 10.1016/j.ebiom.2019.07.067
Lamb, Lydia S., Davis, Timothy M E, Forbes, Josephine, Irrgang, Felix, Golledge, Jonathan, Flicker, Leon and Yeap, Bu B. (2019). Response to Letter to the Editor: "Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men". Journal of Clinical Endocrinology and Metabolism, 104 (3), 684-685. doi: 10.1210/jc.2018-02198
Doola, Ra'eesa, Deane, Adam M., Tolcher, Debbie M., Presneill, Jeffrey J., Barrett, Helen L., Forbes, Josephine M., Todd, Alwyn S., Okano, Satomi and Sturgess, David J. (2019). The effect of a low carbohydrate formula on glycaemia in critically ill enterally-fed adult patients with hyperglycaemia: a blinded randomised feasibility trial. Clinical Nutrition ESPEN, 31, 80-87. doi: 10.1016/j.clnesp.2019.02.013
Lamb, Lydia S., Alfonso, Helman, Norman, Paul E., Davis, Timothy M. E., Forbes, Josephine, Müench, Gerald, Irrgang, Felix, Almeida, Osvaldo P., Golledge, Jonathan, Hankey, Graeme J., Flicker, Leon and Yeap, Bu B. (2018). Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men. Journal of Clinical Endocrinology and Metabolism, 103 (11), 4224-4231. doi: 10.1210/jc.2018-00674
Hagiwara, Shinji, Sourris, Karly, Ziemann, Mark, Tieqiao, Wu, Mohan, Muthukumar, McClelland, Aaron D, Brennan, Eoin, Forbes, Josephine, Coughlan, Melinda, Harcourt, Brooke, Penfold, Sally, Wang, Bo, Higgins, Gavin, Pickering, Raelene, El-Osta, Assam, Thomas, Merlin C, Cooper, Mark E and Kantharidis, Phillip (2018). RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis. Diabetes, 67 (5), 960-973. doi: 10.2337/db17-0538
Doola, Ra'eesa, Todd, Alwyn S., Forbes, Josephine M., Deane, Adam M., Presneill, Jeffrey J. and Sturgess, David J. (2018). Diabetes-specific formulae versus standard formulae as enteral nutrition to treat hyperglycemia in critically ill patients: protocol for a randomized controlled feasibility trial. JMIR Research Protocols, 7 (4) e90, e90. doi: 10.2196/resprot.9374
Mitochondrial dysfunction and signalling in diabetic kidney disease: oxidative stress and beyond
Flemming, Nicole Bernadette, Gallo, Linda Alba and Forbes, Josephine Maree (2018). Mitochondrial dysfunction and signalling in diabetic kidney disease: oxidative stress and beyond. Seminars in Nephrology, 38 (2), 101-110. doi: 10.1016/j.semnephrol.2018.01.001
Mitochondrial dysfunction in diabetic kidney disease
Forbes, Josephine M. and Thorburn, David R. (2018). Mitochondrial dysfunction in diabetic kidney disease. Nature Reviews. Nephrology, 14 (5), 291-312. doi: 10.1038/nrneph.2018.9
Doola, Ra'eesa, Greer, Ristan M., Hurford, Rod, Flatley, Christopher, Forbes, Josephine M., Todd, Alwyn S., Joyce, Chris J. and Sturgess, David J. (2018). Glycaemic variability and its association with enteral and parenteral nutrition in critically ill ventilated patients. Clinical Nutrition, 38 (4), 1707-1712. doi: 10.1016/j.clnu.2018.08.001
Borg, Danielle J., Yap, Felicia Y. T., Keshvari, Sahar, Simmons, David G., Gallo, Linda A., Fotheringham, Amelia K., Zhuang, Aowen, Slattery, Robyn M., Hasnain, Sumaira Z., Coughlan, Melinda T., Kantharidis, Phillip and Forbes, Josephine M. (2017). Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction. Islets, 10 (1), 10-24. doi: 10.1080/19382014.2017.1405189
Glycation: a new hope in targeting hepatocellular carcinoma?
Leung, Christopher, Angus, Peter W. and Forbes, Josephine M. (2017). Glycation: a new hope in targeting hepatocellular carcinoma?. Translational Cancer Research, 6 (S9), S1491-S1497. doi: 10.21037/tcr.2017.11.06
Ward, Micheal S.., Flemming, Nicole B., Gallo, Linda A., Fotheringham, Amelia K., McCarthy, Domenica A., Zhuang, Aowen, Tang, Peter H., Borg, Danielle J., Shaw, Hannah, Harvie, Benjamin, Briskey, David R., Roberts, Llion A., Plan, Manuel R., Murphy, Michael P., Hodson, Mark P. and Forbes, Josephine M. (2017). Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes. Scientific Reports, 7 (1) 15190, 15190. doi: 10.1038/s41598-017-15589-x
Increased liver AGEs induce hepatic injury mediated through an OST48 pathway
Zhuang, Aowen, Yap, Felicia Y. T., Bruce, Clinton, Leung, Chris, Plan, Manuel R., Sullivan, Mitchell A., Herath, Chandana, McCarthy, Domenica, Sourris, Karly C., Kantharidis, Phillip, Coughlan, Melinda T., Febbraio, Mark A. , Hodson, Mark P., Watt, Matthew J., Angus, Peter, Schulz, Benjamin L. and Forbes, Josephine M. (2017). Increased liver AGEs induce hepatic injury mediated through an OST48 pathway. Scientific Reports, 7 (1) 12292, 12292. doi: 10.1038/s41598-017-12548-4
Vascular complications in diabetes: old messages, new thoughts
Forbes, Josephine M. and Fotheringham, Amelia K. (2017). Vascular complications in diabetes: old messages, new thoughts. Diabetologia, 60 (11), 2129-2138. doi: 10.1007/s00125-017-4360-x
Mousa, Aya, de Courten, Maximilian P. J., Forbes, Josephine and de Courten, Barbora (2017). Serum 25-hydroxyvitamin D concentrations are associated with nuclear factor kappa-B activity but not with inflammatory markers in healthy normoglycemic adults. Journal of Steroid Biochemistry and Molecular Biology, 177, 216-222. doi: 10.1016/j.jsbmb.2017.07.013
Baye, Estifanos, de Courten, Maximilian P. J., Walker, Karen, Ranasinha, Sanjeeva, Earnest, Arul, Forbes, Josephine M. and de Courten, Barbora (2017). Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: a randomised crossover trial. Scientific Reports, 7 (1) 4123, 4123. doi: 10.1038/s41598-017-04214-6
Pearce, Karma, Hatzinikolas, Alicia, Moran, Lisa, de Courten, Maximilian P. J., Forbes, Josephine, Scheijen, Jean L. J. M., Schalkwijk, Casper G., Walker, Karen and de Courten, Barbora (2017). Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity. International Journal of Food Sciences and Nutrition, 68 (8), 1-6. doi: 10.1080/09637486.2017.1319468
Salonen, K. M., Ryhanen, S. J., Forbes, J. M., Harkonen, T., Ilonen, J., Simell, O., Veijola, R., Groop, P. -H. and Knip, M. (2017). A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diabetes. Diabetes/Metabolism Research and Reviews, 33 (4) e2872, e2872. doi: 10.1002/dmrr.2872
Receptor for advanced glycation end products (RAGE) in type 1 diabetes pathogenesis
Leung, Sherman S., Forbes, Josephine M. and Borg, Danielle J. (2016). Receptor for advanced glycation end products (RAGE) in type 1 diabetes pathogenesis. Current Diabetes Reports, 16 (10) 100, 100. doi: 10.1007/s11892-016-0782-y
Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease
Leung, Christopher, Herath, Chandana B., Jia, Zhiyuan, Andrikopoulos, Sof, Brown, Bronwyn E., Davies, Michael J., Rivera, Leni R., Furness, John B., Forbes, Josephine M. and Angus, Peter W. (2016). Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease. World Journal of Gastroenterology, 22 (35), 8026-8040. doi: 10.3748/wjg.v22.i35.8026
Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?
Zhuang, Aowen and Forbes, Josephine M. (2016). Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?. Glycoconjugate Journal, 33 (4), 645-652. doi: 10.1007/s10719-016-9693-z
Targeting advanced glycation with pharmaceutical agents: where are we now?
Borg, Danielle J. and Forbes, Josephine M. (2016). Targeting advanced glycation with pharmaceutical agents: where are we now?. Glycoconjugate Journal, 33 (4), 653-670. doi: 10.1007/s10719-016-9691-1
Mitochondria-power players in kidney function?
Forbes, Josephine M. (2016). Mitochondria-power players in kidney function?. Trends in Endocrinology and Metabolism, 27 (7), 441-442. doi: 10.1016/j.tem.2016.05.002
de Courten, Barbora, de Courten, Maximilian P. J., Soldatos, Georgia, Dougherty, Sonia L., Straznicky, Nora, Schlaich, Markus, Sourris, Karly C., Chand, Vibhasha, Scheijen, Jean L. J. M., Kingwell, Bronwyn A., Cooper, Mark E., Schalkwijk, Casper G., Walker, Karen Z. and Forbes, Josephine M. (2016). Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial. American Journal of Clinical Nutrition, 103 (6), 1426-1433. doi: 10.3945/ajcn.115.125427
Gallo, Linda A., Ward, Micheal S., Fotheringham, Amelia K., Zhuang, Aowen, Borg, Danielle J., Flemming, Nicole B., Harvie, Ben M., Kinneally, Toni L., Yeh, Shang-Ming, McCarthy, Domenica A., Koepsell, Hermann, Vallon, Volker, Pollock, Carol, Panchapakesan, Usha and Forbes, Josephine M. (2016). Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice. Scientific Reports, 6 (1) 26428, 28124. doi: 10.1038/srep26428
Coleman, Miranda A., Jessup, Claire F., Bridge, Jennifer A., Overgaard, Nana H., Penko, Daniella, Walters, Stacey, Borg, Danielle J., Galea, Ryan, Forbes, Josephine M., Thomas, Ranjeny, Coates, Patrick T. C., Grey, Shane T., Wells, James W. and Steptoe, Raymond J. (2016). Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes, 65 (5), 1328-1340. doi: 10.2337/db15-1418
Coughlan, Melinda T., Higgins, Gavin C., Tuong-Vi Nguyen, Penfold, Sally A., Thallas-Bonke, Vicki, Tan, Sih Mm, Ramm, Georg, Van Bergen, Nicole J., Henstridge, Darren C., Sourris, Karly C., Harcourt, Brooke E., Trounce, Ian A., Robb, Portia M., Laskowski, Adrienne, McGee, Sean L., Genders, Amanda J., Walder, Ken, Drew, Brian G., Gregorevic, Paul, Qian, Hongwei, Thomas, Merlin C., Jerums, George, Macisaac, Richard J., Skene, Alison, Ekinci, Elif I., Wijeyeratne, Xiaonan W., Gallo, Linda A., Heiman-Edelstein, Michal, Ryan, Michael T. ... Forbes, Josephine M. (2016). Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis. Diabetes, 65 (4), 1085-1098. doi: 10.2337/db15-0864
Gallo, Linda A, Ward, Micheal S, Fotheringham, Amelia K, Zhuang, Aowen, Koepsell, Hermann, Vallon, Volker, Pollock, Carol, Panchapakesan, Usha and Forbes, Josephine M (2016). The SGLT2 Inhibitor, Empagliflozin, Attenuates Some Markers of Renal Fibrosis without Improving Albuminuria in Diabetic Db/Db Mice. The FASEB Journal, 30 (S1). doi: 10.1096/fasebj.30.1_supplement.740.18
Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes
Coughlan, Melinda T., Nguyen, Tuong-Vi, Penfold, Sally A., Higgins, Gavin C., Thallas-Bonke, Vicki, Tan, Sih Min, Van Bergen, Nicole J., Sourris, Karly C., Harcourt, Brooke E., Thorburn, David R., Trounce, Ian A., Cooper, Mark E. and Forbes, Josephine M. (2016). Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes. Clinical Science, 130 (9), 711-720. doi: 10.1042/CS20150838
Synbiotics easing renal failure by improving gut microbiology (SYNERGY): a randomized trial
Rossi, Megan, Johnson, David W., Morrison, Mark, Pascoe, Elaine M., Coombes, Jeff S., Forbes, Josephine M., Szeto, Cheuk-Chun, McWhinney, Brett C., Ungerer, Jacobus P. J. and Campbell, Katrina L. (2016). Synbiotics easing renal failure by improving gut microbiology (SYNERGY): a randomized trial. Clinical Journal of the American Society of Nephrology, 11 (2), 223-231. doi: 10.2215/CJN.05240515
Tapping into mitochondria to find novel targets for diabetes complications
Fleming, Nicole B., Gallo, Linda, Ward, Micheal S. and Forbes, Josephine M. (2016). Tapping into mitochondria to find novel targets for diabetes complications. Current Drug Targets, 17 (12), 1341-1349. doi: 10.2174/1389450116666150727114410
Abdominal obesity and brain atrophy in type 2 diabetes mellitus
Climie, Rachel E. D., Moran, Chris, Callisaya, Michele, Blizzard, Leigh, Sharman, James E., Venn, Alison, Phan, Thanh G., Beare, Richard, Forbes, Josephine, Blackburn, Nicholas B. and Srikanth, Velandai (2015). Abdominal obesity and brain atrophy in type 2 diabetes mellitus. PloS One, 10 (11) e0142589, e0142589. doi: 10.1371/journal.pone.0142589
de Courten, Barbora, de Courten, Maximilian P. J., Schalkwijk, Casper G., Walker, Karen Z. and Forbes, Josephine (2015). Dietary advanced glycation end products consumption as a direct modulator of insulin sensitivity in overweight humans: a study protocol for a double-blind, randomized, two period cross-over trial. JMIR Research Protocols, 4 (3) e93, e93+. doi: 10.2196/resprot.4552
SaO035: Synbiotic therapy in pre-dialysis: a randomised controlled trial
Rossi, Megan, Johnson, David, Pascoe, Elaine, Coombes, Jeff, Forbes, Josephine, Szeto, Cheuk-Chun, McWhinney, Brett, Ungerer, Jacobus and Campbell, Katrina (2015). SaO035: Synbiotic therapy in pre-dialysis: a randomised controlled trial. Nephrology, Dialysis, Transplantation, 30 (suppl_3), iii38-iii38. doi: 10.1093/ndt/gfv152.02
Salonen, Kirsi M., Ryhanen, Samppa J., Forbes, Josephine M., Borg, Danielle J., Harkonen, Taina, Ilonen, Jorma, Simell, Olli, Veijola, Riitta, Groop, Per-Henrik and Knip, Mikael (2015). Decrease in circulating concentrations of soluble receptors for advanced glycation end products at the time of seroconversion to autoantibody positivity in children with prediabetes. Diabetes Care, 38 (4), 665-670. doi: 10.2337/dc14-1186
A rapid extraction method for glycogen from formalin-fixed liver
Sullivan, Mitchell A., Li, Shihan, Aroney, Samuel T.N., Deng, Bin, Li, Cheng, Roura, Eugeni, Schulz, Benjamin L., Harcourt, Brooke E., Forbes, Josephine M. and Gilbert, Robert G. (2015). A rapid extraction method for glycogen from formalin-fixed liver. Carbohydrate Polymers, 118, 9-15. doi: 10.1016/j.carbpol.2014.11.005
de Courten, Barbora, Moreno-Navarrete, Jose Maria, Lyons, Jasmine, Soldatos, Georgia, de Courten, Maximilian, Dougherty, Sonia, Forbes, Josephine and Fernandez-Real, Jose Manuel (2015). Contrasting association of circulating sCD14 with insulin sensitivity in non-obese and morbidly obese subjects. Molecular Nutrition and Food Research, 60 (1), 103-109. doi: 10.1002/mnfr.201500102
Sullivan, Mitchell A., Harcourt, Brooke E., Xu, Ping, Forbes, Josephine M. and Gilbert, Robert G. (2015). Impairment of liver glycogen storage in the db/db animal model of type 2 diabetes: a potential target for future therapeutics?. Current Drug Targets, 16 (10), 1088-1093. doi: 10.2174/1389450116666150727123115
Type 2 diabetes, skin autofluorescence, and brain atrophy
Moran, C., Munch, G., Forbes, J.M., Beare, R., Blizzard, L., Venn, A.J., Phan, T.G., Chen, J. and Srikanth, V. (2015). Type 2 diabetes, skin autofluorescence, and brain atrophy. Diabetes, 64 (1), 279-283. doi: 10.2337/db14-0506
Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonghua H., Ng, Choa Ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014). Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12), 1417-1426. doi: 10.1038/nm.3705
Thallas‐Bonke, Vicki, Jha, Jay C., Gray, Stephen P., Barit, David, Haller, Hermann, Schmidt, Harald H.H.W., Coughlan, Melinda T., Cooper, Mark E., Forbes, Josephine M. and Jandeleit‐Dahm, Karin A.M. (2014). Nox‐4 deletion reduces oxidative stress and injury by PKC‐α‐associated mechanisms in diabetic nephropathy. Physiological Reports, 2 (11) e12192, e12192.1-e12192.13. doi: 10.14814/phy2.12192
Tesch, Greg, Sourris, Karly C., Summers, Shaun A., McCarthy, Domenica, Ward, Micheal S., Borg, Danielle J., Gallo, Linda A., Fotheringham, Amelia K., Pettit, Allison R., Yap, Felicia Y. T., Harcourt, Brooke E., Tan, Adeline L. Y., Kausman, Joshua Y., Nikolic-Paterson, David, Kitching, Arthur R. and Forbes, Josephine M. (2014). Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes. Diabetologia, 57 (9), 1977-1985. doi: 10.1007/s00125-014-3291-z
Zhuang, Aowen and Forbes, Josephine M. (2014). Stress in the kidney is the road to pERdition: is endoplasmic reticulum stress a pathogenic mediator of diabetic nephropathy?. Journal of Endocrinology, 222 (3), R97-R111. doi: 10.1530/JOE-13-0517
Fukami, Kei, Yamagishi, Sho-ichi, Coughlan, Melinda T., Harcourt, Brooke E., Kantharidis, Phillip, Thallas-Bonke, Vicki, Okuda, Seiya, Cooper, Mark E. and Forbes, Josephine M. (2014). Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy. Diabetology and Metabolic Syndrome, 6 (1) 86, 86. doi: 10.1186/1758-5996-6-86
Salonen, Kirsi M., Ryhanen, Samppa J., Forbes, Josephine M., Harkonen, Taina, Ilonen, Jorma, Laine, Antti-Pekka, Groop, Per-Henrik and Knip, Mikael (2014). Circulating concentrations of soluble receptor for AGE are associated with age and AGER gene polymorphisms in children with newly diagnosed type 1 diabetes. Diabetes Care, 37 (7), 1975-1981. doi: 10.2337/dc13-3049
Rossi, Megan, Johnson, David W., Morrison, Mark, Pascoe, Elaine, Coombes, Jeff S., Forbes, Josephine M., McWhinney, Brett C., Ungerer, Jacobus P. J., Dimeski, Goce and Campbell, Katrina L. (2014). SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial. BMC Nephrology, 15 (1) 106, 106.1-106.10. doi: 10.1186/1471-2369-15-106
Dietary glycotoxins exacerbate progression of experimental fatty liver disease
Leung, Christopher, Herath, Chandana B., Jia, Zhiyuan, Goodwin, Michelle, Mak, Kai Yan, Watt, Matthew J., Forbes, Josephine M. and Angus, Peter W. (2014). Dietary glycotoxins exacerbate progression of experimental fatty liver disease. Journal of Hepatology, 60 (4), 832-838. doi: 10.1016/j.jhep.2013.11.033
Sourris, Karly C., Lyons, Jasmine G., Dougherty, Sonia L., Chand, Vibhasha, Straznicky, Nora E., Schlaich, Markus P., Grima, Mariee T., Cooper, Mark E., Kingwell, Bronwyn A., de Courten, Maximilian P. J., Forbes, Josephine M. and de Courten, Barbora (2014). Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure. Clinical Chemistry and Laboratory Medicine, 52 (1), 129-138. doi: 10.1515/cclm-2012-0850
Dietary advanced glycation end products as an environmental contributor to type 1 diabetes
Borg, Danielle J. and Forbes, Josephine M. (2013). Dietary advanced glycation end products as an environmental contributor to type 1 diabetes. IMARS Highlights, 8 (5), 21-22.
Penno, Megan A. S., Couper, Jennifer J., Craig, Maria E., Colman, Peter G., Rawlinson, William D., Cotterill, Andrew M., Jones, Timothy W., Harrison, Leonard C., ENDIA Study Group and Forbes, Josephine M. (2013). Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes. BMC Pediatrics, 13 (1) 124, 124.1-124.15. doi: 10.1186/1471-2431-13-124
Forbes, Josephine M., Ke, Bi-Xia, Tuong-Vi Nguyen, Henstridge, Darren C., Penfold, Sally A., Laskowski, Adrienne, Sourris, Karly C., Groschner, Lukas N., Cooper, Mark E., Thorburn, David R. and Coughlan, Melinda T. (2013). Deficiency in mitochondrial complex I activity due to Ndufs6 gene trap insertion induces renal disease. Antioxidants and Redox Signaling, 19 (4), 331-343. doi: 10.1089/ars.2012.4719
Siebel, Andrew L., Natoli, Alaina K., Yap, Felicia Y. T., Carey, Andrew L., Reddy-Luthmoodoo, Medini, Sviridov, Dmitri, Weber, Chek Ing Kiu, Meneses-Lorente, Georgina, Maugeais, Cyrille, Forbes, Josephine M. and Kingwell, Bronwyn A. (2013). Effects of high-density lipoprotein elevation with cholesteryl ester transfer protein inhibition on insulin secretion. Circulation Research, 113 (2), 167-175. doi: 10.1161/CIRCRESAHA.113.300689
Forbes, Josephine M., Cowan, Samantha P., Andrikopoulos, Sofianos, Morley, Amy L., Ward, Leigh C., Walker, Karen Z., Cooper, Mark E. and Coughlan, Melinda T. (2013). Glucose homeostasis can be differentially modulated by varying individual components of a western diet. Journal of Nutritional Biochemistry, 24 (7), 1251-1257. doi: 10.1016/j.jnutbio.2012.09.009
Insulin infusion reduces hepatocyte growth factor in lean humans
de Courten, Barbora, de Courten, Maximilian P. J., Dougherty, Sonia, Forbes, Josephine M., Potts, Jenna R. and Considine, Robert V. (2013). Insulin infusion reduces hepatocyte growth factor in lean humans. Metabolism: Clinical and Experimental, 62 (5), 647-650. doi: 10.1016/j.metabol.2012.10.013
Panchapakesan, Usha, Pegg, Kate, Gross, Simon, Komala, Muralikrishna Gangadharan, Mudaliar, Harshini, Forbes, Josephine, Pollock, Carol and Mather, Amanda (2013). Effects of SGLT2 Inhibition in Human Kidney Proximal Tubular Cells-Renoprotection in Diabetic Nephropathy?. PLoS One, 8 (2) e54442, e54442.1-e54442.8. doi: 10.1371/journal.pone.0054442
Advanced glycation end products augment experimental hepatic fibrosis
Goodwin, Michelle, Herath, Chandana, Jia, Zhiyuan, Leung, Chris, Coughlan, Melinda T., Forbes, Josephine and Angus, Peter (2013). Advanced glycation end products augment experimental hepatic fibrosis. Journal of Gastroenterology and Hepatology, 28 (2), 369-376. doi: 10.1111/jgh.12042
Forbes, Josephine M., Sourris, Karly C., de Courten, Maximilian P. J., Dougherty, Sonia L., Chand, Vibhasha, Lyons, Jasmine G., Bertovic, David, Coughlan, Melinda T., Schlaich, Markus P., Soldatos, Georgia, Cooper, Mark E., Straznicky, Nora E., Kingwell, Bronwyn A. and de Courten, Barbora (2013). Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects. Amino Acids, 46 (2), 321-326. doi: 10.1007/s00726-013-1542-9
Brain atrophy in type 2 diabetes: regional distribution and influence on cognition
Moran, Chris, Phan, Thanh G., Chen, Jian, Blizzard, Leigh, Beare, Richard, Venn, Alison, Munch, Gerald, Wood, Amanda G., Forbes, Josephine, Greenaway, Timothy M., Pearson, Susan and Srikanth, Velandai (2013). Brain atrophy in type 2 diabetes: regional distribution and influence on cognition. Diabetes Care, 36 (12), 4036-4042. doi: 10.2337/dc13-0143
Coming full circle in diabetes mellitus: From complications to initiation
Harcourt, Brooke E., Penfold, Sally A. and Forbes, Josephine M. (2013). Coming full circle in diabetes mellitus: From complications to initiation. Nature Reviews Endocrinology, 9 (2), 113-123. doi: 10.1038/nrendo.2012.236
Mechanisms of diabetic complications
Forbes, Josephine M. and Cooper, Mark E. (2013). Mechanisms of diabetic complications. Physiological Reviews, 93 (1), 137-188. doi: 10.1152/physrev.00045.2011
Methylglyoxal, cognitive function and cerebral atrophy in older people
Srikanth, Velandai, Westcott, Bernadette, Forbes, Josephine, Phan, Thanh G., Beare, Richard, Venn, Alison, Pearson, Sue, Greenaway, Tim, Parameswaran, Venkat and Muench, Gerald (2013). Methylglyoxal, cognitive function and cerebral atrophy in older people. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 68 (1), 68-73. doi: 10.1093/gerona/gls100
Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease
Ward, Micheal S., Fortheringham, Amelia K., Cooper, Mark E . and Forbes, Josephine M. (2013). Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease. Current Opinion in Pharmacology, 13 (4), 654-661. doi: 10.1016/j.coph.2013.06.009
Thallas-Bonke, Vicki, Coughlan, Melinda T, Tan, Adeline LY, Harcourt, Brooke E, Morgan, Philip E, Davies, Michael J, Bach, Leon A, Cooper, Mark E and Forbes, Josephine M (2013). Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content.. Nephrology (Carlton, Vic.), 18 (1), 47-56. doi: 10.1111/j.1440-1797.2012.01665.x
Bierhaus, Angelika, Fleming, Thomas, Stoyanov, Stoyan, Leffler, Andreas, Babes, Alexandru, Neacsu, Cristian, Sauer, Susanne K., Eberhardt, Mirjam, Schnölzer, Martina, Lasischka, Felix, Neuhuber, Winfried L., Kichko, Tatjana I., Konrade, Ilze, Elvert, Ralf, Mier, Walter, Pirags, Valdis, Lukic, Ivan K., Morcos, Michael, Dehmer, Thomas, Rabbani, Naila, Thornalley, Paul J., Edelstein, Diane, Nau, Carla, Forbes, Josephine, Humpert, Per M., Schwaninger, Markus, Ziegler, Dan, Stern, David M., Cooper, Mark E. ... Nawroth, Peter P. (2012). Erratum: methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy (Nature Medicine (2012) 18 (926-933)). Nature Medicine, 18 (9), 1445-1445. doi: 10.1038/nm0912-1445c
Low, H., Hoang, A., Forbes, J., Thomas, M., Lyons, J. G., Nestel, P., Bach, L. A. and Sviridov, D. (2012). Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models. Diabetologia, 55 (9), 2513-2521. doi: 10.1007/s00125-012-2570-9
Bierhaus, Angelika, Fleming, Thomas, Stoyanov, Stoyan, Leffler, Andreas, Babes, Alexandru, Neacsu, Cristian, Sauer, Susanne K., Eberhardt, Mirjam, Schnoelzer, Martina, Lasischka, Felix, Neuhuber, Winfried L., Kichko, Tatjana I., Konrade, Ilze, Elvert, Ralf, Mier, Walter, Pirags, Valdis, Lukic, Ivan K., Morcos, Michael, Dehmer, Thomas, Rabbani, Naila, Thornalley, Paul J., Edelstein, Diane, Nau, Carla, Forbes, Josephine, Humpert, Per M., Schwaninger, Markus, Ziegler, Dan, Stern, David M., Cooper, Mark E. ... Nawroth, Peter P. (2012). Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nature Medicine, 18 (6), 926-933. doi: 10.1038/nm.2750
Huynh, K., Kiriazis, H., Du, X. -J., Love, J. E., Jandeleit-Dahm, K. A., Forbes, J. M., McMullen, J. R. and Ritchie, R. H. (2012). Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes. Diabetologia, 55 (5), 1544-1553. doi: 10.1007/s00125-012-2495-3
Advanced glycation end products as environmental risk factors for the development of type 1 diabetes
Yap, Felicia Y. T., Kantharidis, Phillip, Coughlan, Melinda T., Slattery, Robyn and Forbes, Josephine M. (2012). Advanced glycation end products as environmental risk factors for the development of type 1 diabetes. Current Drug Targets, 13 (4), 526-540. doi: 10.2174/138945012799499758
Glycation in diabetic nephropathy
Forbes, Josephine M. and Cooper, Mark E. (2012). Glycation in diabetic nephropathy. Amino Acids, 42 (4), 1185-1192. doi: 10.1007/s00726-010-0771-4
Sourris, Karly C., Harcourt, Brooke E., Tang, Peter H., Morley, Amy L., Karina Huynh, Penfold, Sally A., Coughlan, Melinda T., Cooper, Mark E., Tuong-Vi Nguyen, Ritchie, Rebecca H. and Forbes, Josephine M. (2012). Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. Free Radical Biology and Medicine, 52 (3), 716-723. doi: 10.1016/j.freeradbiomed.2011.11.017
Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice
Harcourt, Brooke E., Forbes, Josephine M. and Matthews, Vance B. (2012). Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice. Nephrology, 17 (3), 257-262. doi: 10.1111/j.1440-1797.2011.01547.x
Advanced glycation end products are direct modulators of β-cell function
Coughlan, Melinda T., Yap, Felicia Y. T., Tong, David C. K., Andrikopoulos, Sofianos, Gasser, Anna, Thallas-Bonke, Vicki, Webster, Diane E., Miyazaki, Jun-ichi, Kay, Thomas W., Slattery, Robyn M., Kaye, David M., Drew, Brian G., Kingwell, Bronwyn A., Fourlanos, Spiros, Groop, Per-Henrik, Harrison, Leonard C., Knip, Mikael and Forbes, Josephine M. (2011). Advanced glycation end products are direct modulators of β-cell function. Diabetes, 60 (10), 2523-2532. doi: 10.2337/db10-1033
Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man
Coughlan, Melinda T., Patel, Sheila K., Jerums, George, Penfold, Sally A., Nguyen, Tuong-Vi, Sourris, Karly C., Panagiotopoulos, Sianna, Srivastava, Piyush M., Cooper, Mark E., Burrell, Louise M., MacIsaac, Richard J. and Forbes, Josephine M. (2011). Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man. American Journal of Nephrology, 34 (4), 347-355. doi: 10.1159/000331064
Krautwald, Martina, Leech, Dale, Horne, Stacey, Steele, Megan L., Forbes, Josephine, Rahmadi, Anton, Griffith, Renate and Muench, Gerald (2011). The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase. Rejuvenation Research, 14 (4), 383-391. doi: 10.1089/rej.2010.1143
Targeted reduction of advanced glycation improves renal function in obesity
Harcourt, Brooke E., Sourris, Karly C., Coughlan, Melinda T., Walker, Karen Z., Dougherty, Sonia L., Andrikopoulos, Sofianos, Morley, Amy L., Thallas-Bonke, Vicki, Chand, Vibhasha, Penfold, Sally A., de Courten, Maximilian P. J., Thomas, Merlin C., Kingwell, Bronwyn A., Bierhaus, Angelika, Cooper, Mark E., de Courten, Barbora and Forbes, Josephine M. (2011). Targeted reduction of advanced glycation improves renal function in obesity. Kidney International, 80 (2), 190-198. doi: 10.1038/ki.2011.57
Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes
Coughlan, Melinda T. and Forbes, Josephine M. (2011). Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes. American Journal of Nephrology, 34 (1), 9-17. doi: 10.1159/000328581
Forbes, J. M., Söderlund, J., Yap, F. Y. T., Knip, M., Andrikopoulos, S., Ilonen, J., Simell, O., Veijola, R., Sourris, K. C., Coughlan, M. T., Forsblom, C., Slattery, R., Bierhaus, A., Grey, S. T., Wessman, M., Yamamoto, H., Cooper, M. E. and Groop, P.-H. (2011). Erratum to: Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia, 54 (6), 1586-1587. doi: 10.1007/s00125-011-2145-1
Forbes, J. M., Soderlund, J., Yap, F. Y. T., Knip, M., Andrikopoulos, S., Ilonen, J., Simell, O., Veijola, R., Sourris, K. C., Coughlan, M. T., Forsblom, C., Slattery, R., Grey, S. T., Wessman, M., Yamamoto, H., Bierhaus, A., Cooper, M. E. and Groop, P.-H. (2011). Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia, 54 (5), 1032-1042. doi: 10.1007/s00125-011-2058-z
Mangat, R., Su, J. W., Lambert, J. E., Clandinin, M. T., Wang, Y., Uwiera, R. R., Forbes, J. M., Vine, D. F., Cooper, M. E., Mamo, J. C. and Proctor, S. D. (2011). Increased risk of cardiovascular disease in Type 1 diabetes: arterial exposure to remnant lipoproteins leads to enhanced deposition of cholesterol and binding to glycated extracellular matrix proteoglycans. Diabetic Medicine, 28 (1), 61-72. doi: 10.1111/j.1464-5491.2010.03138.x
Sourris, K. C., Morley, A. L., Koitka, A., Samuel, P., Coughlan, M. T., Penfold, S. A., Thomas, M. C., Bierhaus, A., Nawroth, P. P., Yamamoto, H., Allen, T. J., Walther, T., Hussain, T., Cooper, M. E. and Forbes, J. M. (2010). Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor. Diabetologia, 53 (11), 2442-2451. doi: 10.1007/s00125-010-1837-2
Henstridge, Darren C., Forbes, Josephine M., Penfold, Sally A., Formosa, Melissa F., Dougherty, Sonia, Gasser, Anna, de Courten, Maximilian P., Cooper, Mark E., Kingwell, Bronwyn A. and de Courten, Barbora (2010). The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity. Metabolism: Clinical and Experimental, 59 (11), 1556-1561. doi: 10.1016/j.metabol.2010.01.027
Forbes, Josephine M. (2010). The physiological deadlock between AMPK and gluconeogenesis: SOGA, a novel protein, may provide the key. American Journal of Pathology, 177 (4), 1600-1602. doi: 10.2353/ajpath.2010.100679
The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse
Giunti, Sara, Calkin, Anna C., Forbes, Josephine M., Allen, Terri J., Thomas, Merlin C., Cooper, Mark E. and Jandeleit-Dahm, Karin A. (2010). The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse. American Journal of Physiology - Renal Physiology, 299 (3), F528-F535. doi: 10.1152/ajprenal.00127.2010
Penfold, Sally A., Coughlan, Melinda T., Patel, Sheila K., Srivastava, Piyush M., Sourris, Karly C., Steer, David, Webster, Diane E., Thomas, Merlin C., MacIsaac, Richard J., Jerums, George, Burrell, Louise M., Cooper, Mark E. and Forbes, Josephine M. (2010). Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy. Kidney International, 78 (3), 287-295. doi: 10.1038/ki.2010.134
Norman, Paul E., Davis, Wendy A., Coughlan, Melinda T., Forbes, Josephine M., Golledge, Jonathan and Davis, Timothy M. E. (2010). Reply. Journal of Vascular Surgery, 52 (2), 536-536. doi: 10.1016/j.jvs.2010.04.032
Thallas-Bonke, Vicki, Coughlan, Melinda T., Bach, Leon A., Cooper, Mark E. and Forbes, Josephine M. (2010). Preservation of kidney function with combined inhibition of NADPH oxidase and angiotensin-converting enzyme in diabetic nephropathy. American Journal of Nephrology, 32 (1), 73-82. doi: 10.1159/000314924
Soro-Paavonen, Aino, Zhang, Wei-Zeng, Venardos, Kylie, Coughlan, Melinda T., Harris, Emma, Tong, David C. K., Brasacchio, Daniella, Paavonen, Karri, Chin-Dusting, Jaye, Cooper, Mark E., Kaye, David, Thomas, Merlin C. and Forbes, Josephine M. (2010). Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase. Journal of Hypertension, 28 (4), 780-788. doi: 10.1097/HJH.0b013e328335043e
Forbes, J. M., Cooper, M. E., Thallas, V., Burns, W. C., Thomas, M. C., Brammar, G. C., Lee, F., Grant, S. L., Burrell, L. A., Jerums, G. and Osicka, T. M. (2010). Errata: Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy (Diabetes (2002) 51, (3274-3282)). Diabetes, 59 (4), 1113-1114. doi: 10.2337/db10-er04a
Tan, Adeline L. Y., Sourris, Karly C., Harcourt, Brooke E., Thallas-Bonke, Vicki, Penfold, Sally, Andrikopoulos, Sofianos, Thomas, Merlin C., O'Brien, Richard C., Bierhaus, Angelika, Cooper, Mark E., Forbes, Josephine M. and Coughlan, Melinda T. (2010). Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy. American Journal of Physiology - Renal Physiology, 298 (3), F763-F770. doi: 10.1152/ajprenal.00591.2009
Sourris, Karly C., Harcourt, Brooke E., Penfold, Sally A., Yap, Felicia Y. T., Morley, Amy L., Morgan, Philip E., Davies, Michael J., Baker, Scott T., Jerums, George and Forbes, Josephine M. (2010). Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy. Experimental Diabetes Research, 2010 (Art No.: 974681) 974681, 1-9. doi: 10.1155/2010/974681
Norman, Paul E., Davis, Wendy A., Coughlan, Melinda T., Forbes, Josephine M., Golledge, Jonathan and Davis, Timothy M. E. (2009). Serum carboxymethyllysine concentrations are reduced in diabetic men with abdominal aortic aneurysms: Health In Men study. Journal of Vascular Surgery, 50 (3), 626-631. doi: 10.1016/j.jvs.2009.05.058
Sourris, Karly C., Lyons, Jasmine G., de Courten, Maximilian P. J., Dougherty, Sonia L., Henstridge, Darren C., Cooper, Mark E., Hage, Michelle, Dart, Anthony, Kingwell, Bronwyn A., Forbes, Josephine M. and de Courten, Barbora (2009). c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-κB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals. Diabetes, 58 (6), 1259-1265. doi: 10.2337/db08-1725
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus
Drew, Brian G., Duffy, Stephen J., Formosa, Melissa F., Natoli, Alaina K., Henstridge, Darren C., Penfold, Sally A., Thomas, Walter G., Mukhamedova, Nigora, de Courten, Barbora, Forbes, Josephine M., Yap, Felicia Y., Kaye, David M., van Hall, Gerrit, Febbraio, Mark A., Kemp, Bruce E., Sviridov, Dmitri, Steinberg, Gregory R. and Kingwell, Bronwyn A. (2009). High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. Circulation, 119 (15), 2103-2111. doi: 10.1161/CIRCULATIONAHA.108.843219
Koska, J., Ortega, E., Bunt, J. C., Gasser, A., Impson, J., Hanson, R. L., Forbes, J., de Courten, B. and Krakoff, J. (2009). The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study. Diabetologia, 52 (3), 385-393. doi: 10.1007/s00125-008-1239-x
Sourris, Karly C., Harcourt, Brooke E. and Forbes, Josephine M. (2009). A new perspective on therapeutic inhibition of advanced glycation in diabetic microvascular complications: Common downstream endpoints achieved through disparate therapeutic approaches?. American Journal of Nephrology, 30 (4), 323-335. doi: 10.1159/000226586
Sourris, Karly C. and Forbes, Josephine M. (2009). Interactions Between Advanced Glycation End-Products (AGE) and their Receptors in the Development and Progression of Diabetic Nephropathy - are these Receptors Valid Therapeutic Targets. Current Drug Targets, 10 (1), 42-50. doi: 10.2174/138945009787122905
Rage-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes
Coughlan, Melinda T., Thorburn, David R., Penfold, Sally A., Laskowski, Adrienne, Harcourt, Brooke E., Sourris, Karly C., Tan, Adeline L. Y., Fukami, Kei, Thallas-Bonke, Vicki, Nawroth, Peter P., Brownlee, Michael, Bierhaus, Angelika, Cooper, Mark E. and Forbes, Josephine M. (2009). Rage-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. Journal of the American Society of Nephrology, 20 (4), 742-752. doi: 10.1681/ASN.2008050514
Heat shock protein expression in diabetic nephropathy
Barutta, Federica, Pinach, Silvia, Giunti, Sara, Vittone, Ferdinando, Forbes, Josephine M., Chiarle, Roberto, Arnstein, Maryann, Perin, Paolo Cavallo, Camussi, Giovanni, Cooper, Mark E. and Gruden, Gabriella (2008). Heat shock protein expression in diabetic nephropathy. American Journal of Physiology - Renal Physiology, 295 (6), F1817-F1824. doi: 10.1152/ajprenal.90234.2008
Soro-Paavonen, Aino, Watson, Anna M. D., Li, Jiaze, Paavonen, Karri, Koitka, Audrey, Calkin, Anna C., Barit, David, Coughlan, Melinda T., Drew, Brian G., Lancaster, Graeme I., Thomas, Merlin, Forbes, Josephine M., Nawroth, Peter P., Bierhaus, Angelika, Cooper, Mark E. and Jandeleit-Dahm, Karin A. (2008). Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes. Diabetes, 57 (9), 2461-2469. doi: 10.2337/db07-1808
Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs
Tikellis, Christos, Thomas, Merlin C., Harcourt, Brooke E., Coughlan, Melinda T., Pete, Josepha, Bialkowski, Katarzyna, Tan, Adeline, Bierhaus, Angelika, Cooper, Mark E. and Forbes, Josephine M. (2008). Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs. American Journal of Physiology: Endocrinology and Metabolism, 295 (2), E323-E330. doi: 10.1152/ajpendo.00024.2008
Oxidative stress as a major culprit in kidney disease in diabetes
Forbes, Josephine M., Coughlan, Melinda T. and Cooper, Mark E. (2008). Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes, 57 (6), 1446-1454. doi: 10.2337/db08-0057
Thallas-Bonke, Vicki and Forbes, Josephine M. (2008). Response to comment on: Thallas-bonke et al. (2008) inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-α-dependent pathway:Diabetes 57:460-469, 2008. Diabetes, 57 (6), e14-e14. doi: 10.2337/db08-0406
Fukuda, Kyoichi, Tesch, Greg H., Yap, Felicia Y., Forbes, Josephine M., Flavell, Richard A., Davis, Roger J. and Nikolic-Paterson, David J. (2008). MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model. Laboratory Investigation, 88 (4), 398-407. doi: 10.1038/labinvest.2008.10
Thallas-Bonke, Vicki, Thorpe, Suzanne R., Coughlan, Melinda T., Fukami, Kei, Yap, Felicia Y. T., Sourris, Karly C., Penfold, Sally A., Bach, Leon A., Cooper, Mark E. and Forbes, Josephine M. (2008). Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-α-dependent pathway. Diabetes, 57 (2), 460-469. doi: 10.2337/db07-1119
Advanced glycation: implications in tissue damage and disease
Gasser, Anna and Forbes, Josephine M. (2008). Advanced glycation: implications in tissue damage and disease. Protein and Peptide Letters, 15 (4), 385-391. doi: 10.2174/092986608784246515
Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties
Hoang, A., Murphy, A. J., Coughlan, M. T., Thomas, M. C., Forbes, J. M., O'Brien, R., Cooper, M. E., Chin-Dusting, J. P. F. and Sviridov, D. (2007). Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties. Diabetologia, 50 (8), 1770-1779. doi: 10.1007/s00125-007-0718-9
Coughlan, Melinda T., Thallas-Bonke, Vicki, Pete, Josefa, Long, David M., Gasser, Anna, Tong, David C. K., Arnstein, Maryann, Thorpe, Suzanne R., Cooper, Mark E. and Forbes, Josephine M. (2007). Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or redundancy?. Endocrinology, 148 (2), 886-895. doi: 10.1210/en.2006-1300
AGE, RAGE, and ROS in diabetic nephropathy
Ton, Adeline L. Y., Forbes, Josephine M. and Cooper, Mark E. (2007). AGE, RAGE, and ROS in diabetic nephropathy. Seminars in Nephrology, 27 (2), 130-143. doi: 10.1016/j.semnephrol.2007.01.006
Renal microvascular injury in diabetes: RAGE and redox signaling
Coughlan, Melinda T., Cooper, Mark E. and Forbes, Josephine M. (2007). Renal microvascular injury in diabetes: RAGE and redox signaling. Antioxidants and Redox Signaling, 9 (3), 331-342. doi: 10.1089/ars.2006.1469
Diabetic nephropathy: where hemodynamics meets metabolism
Forbes, J. M., Fukami, K. and Cooper, M. E. (2007). Diabetic nephropathy: where hemodynamics meets metabolism. Experimental and Clinical Endocrinology and Diabetes, 115 (2), 69-84. doi: 10.1055/s-2007-949721
Burns, Wendy C., Twigg, Stephen M., Forbes, Josephine M., Pete, Josefa, Tikellis, Christos, Thallas-Bonke, Vicki, Thomas, Merlin C., Cooper, Mark E. and Kantharidis, Phillip (2006). Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease. Journal of the American Society of Nephrology, 17 (9), 2484-2494. doi: 10.1681/ASN.2006050525
Zimanyi, M. A., Denton, K. M., Forbes, J. M., Thallas-Bonke, V., Thomas, M. C., Poon, F. and Black, M. J. (2006). A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to advanced glycation end-products. Diabetologia, 49 (4), 801-810. doi: 10.1007/s00125-006-0175-x
Forbes, J. M., Yee, L. T.L., Thallas, V., Lassila, M., Candido, R., Jandeleit-Dahm, K. A., Thomas, M. C., Burns, W. C., Deemer, E. K., Thorpe, S. R., Cooper, M. E. and Allen, T. J. (2006). Erratum: Advanced glycation end product intervention reduce diabetes-accelerated atherosclerosis (Diabetes (2005) 53, (1813-1823)). Diabetes, 55 (3)
Novel therapeutics for diabetic micro- and macrovascular complications
Soro-Paavonen, A. and Forbes, J. M. (2006). Novel therapeutics for diabetic micro- and macrovascular complications. Current Medicinal Chemistry, 13 (15), 1777-1788. doi: 10.2174/092986706777452515
Interactions between renin angiotensin system and advanced glycation in the kidney
Thomas, Merlin C., Tikellis, Christos, Burns, Wendy M., Bialkowski, Katarzyna, Cao, Zemin, Coughlan, Melinda T., Jandeleit-Dahm, Karen, Cooper, Mark E. and Forbes, Josephine M. (2005). Interactions between renin angiotensin system and advanced glycation in the kidney. Journal of the American Society of Nephrology, 16 (10), 2976-2984. doi: 10.1681/ASN.2005010013
Calkin, Anna C., Forbes, Josephine M., Smith, Craig M., Lassila, Markus, Cooper, Mark E., Jandeleit-Dahm, Karin A. and Allen, Terri J. (2005). Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects. Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (9), 1903-1909. doi: 10.1161/01.ATV.0000177813.99577.6b
Kooptiwut, Suwattanee, Kebede, Melkam, Zraika, Sakeneh, Visinoni, Sherley, Aston-Mourney, Kathryn, Favaloro, Jenny, Tikellis, Chris, Thomas, Merlin C., Forbes, Josephine M., Cooper, Mark E., Dunlop, Marjorie, Proietto, Joseph and Andrikopoulos, Sofianos (2005). High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction. Journal of Molecular Endocrinology, 35 (1), 39-48. doi: 10.1677/jme.1.01720
Forbes, Josephine M., Thorpe, Suzanne R., Thallas-Bonke, Vicki, Pete, Josefa, Thomas, Merlin C., Deemer, Elizabeth R., Bassal, Sahar, El-Osta, Assam, Long, David M., Panagiotopoulos, Sianna, Jerums, George, Osicka, Tanya M. and Cooper, Mark E. (2005). Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy. Journal of the American Society of Nephrology, 16 (8), 2363-2372. doi: 10.1681/ASN.2005010062
Agents in development for the treatment of diabetic nephropathy
Fukami, Kei, Cooper, Mark and Forbes, Josephine M. (2005). Agents in development for the treatment of diabetic nephropathy. Expert Opinion On Investigational Drugs, 14 (3), 279-294. doi: 10.1517/13543784.14.3.279
Interactions between the renin angiotensin system and advanced glycation in diabetic nephropathy
Thomas, M. C., Forbes, J. M. and Cooper, M. E. (2005). Interactions between the renin angiotensin system and advanced glycation in diabetic nephropathy. Annals of the New York Academy of Sciences, 1043 (1), 927-927. doi: 10.1196/annals.1333.141
Rizkalla, Bishoy, Forbes, Josephine M., Cao, Zemin, Boner, Geoffrey and Cooper, Mark E. (2005). Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system. Journal of Hypertension, 23 (1), 153-164. doi: 10.1097/00004872-200501000-00026
Thallas-Bonke, Vicki, Lindschau, Carsten, Rizkalla, Bishoy, Bach, Leon A., Boner, Geoffrey, Meier, Matthias, Haller, Hermann, Cooper, Mark E. and Forbes, Josephine M. (2004). Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-α - dependent pathway. Diabetes, 53 (11), 2921-2930. doi: 10.2337/diabetes.53.11.2921
Forbes, Josephine M., Thomas, Merlin C., Thorpe, Suzanne R., Alderson, Nathan L. and Cooper, Mark E. (2004). The effects of valsartan on the accumulation of circulating and renal advanced glycation end products in experimental diabetes. Kidney International, Supplement, 66 (S92), S105-S107. doi: 10.1111/j.1523-1755.2004.09225.x
Thomas, Merlin C., Tikellis, Christos, Kantharidis, Phillip, Burns, Wendy C., Cooper, Mark E. and Forbes, Josephine M. (2004). The role of advanced glycation in reduced organic cation transport associated with experimental diabetes. Journal of Pharmacology and Experimental Therapeutics, 311 (2), 456-466. doi: 10.1124/jpet.104.070672
Lassila, Markus, Seah, Kwee K., Allen, Terri J., Thallas, Vicki, Thomas, Merlin C., Candido, Riccardo, Burns, Wendy C., Forbes, Josephine M., Calkin, Anna C., Cooper, Mark E. and Jandeleit-Dahm, Karin A. M. (2004). Accelerated nephropathy in diabetic apolipoprotein E-knockout mouse: role of advanced glycation end products. Journal of the American Society of Nephrology, 15 (8), 2125-2138. doi: 10.1097/01.ASN.0000133025.23732.46
Lee, Fiona T. H., Cao, Zemin, Long, David M., Panagiotopoulos, Sianna, Jerums, George, Cooper, Mark E. and Forbes, Josephine M. (2004). Interactions between angiotensin II and NF-κB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. Journal of the American Society of Nephrology, 15 (8), 2139-2151. doi: 10.1097/01.ASN.0000135055.61833.A8
Advanced glycation end product-interventions reduce diabetes-accelerated atherosclerosis
Forbes, Josephine M., Yee, Louis Teo Loon, Thallas, Vicki, Lassila, Markus, Candido, Riccardo, Jandeleit-Dahm, Karin A., Thomas, Merlin C., Burns, Wendy C., Deemer, Elizabeth K., Thorpe, Susan M., Cooper, Mark E. and Allen, Terri J. (2004). Advanced glycation end product-interventions reduce diabetes-accelerated atherosclerosis. Diabetes, 53 (7), 1813-1823. doi: 10.2337/diabetes.53.7.1813
Wigg, SJ, Tare, M, Forbes, J, Cooper, ME, Thomas, MC, Coleman, HA, Parkington, HC and O'Brien, RC (2004). Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats. Diabetologia, 47 (6), 1038-1046. doi: 10.1007/s00125-004-1411-x
Forbes, Josephine M., Thallas-Bonke, Vicki, Cooper, Mark E. and Thomas, Merlin C. (2004). Advanced glycation: how are we progressing to combat this web of sugar anomalies in diabetic nephropathy. Current Pharmaceutical Design, 10 (27), 3361-3372. doi: 10.2174/1381612043383151
Identification of angiotensin converting enzyme 2 in the rodent retina
Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W., Thomas, M. C., Lew, R. A., Yarski, M., Smith, A. I. and Cooper, M. E. (2004). Identification of angiotensin converting enzyme 2 in the rodent retina. Current Eye Research, 29 (6), 419-427. doi: 10.1080/02713680490517944
Davis, B. J., Forbes, J. M., Thomas, M. C., Jerums, G., Burns, W. C., Kawachi, H., Allen, T. J. and Cooper, M. E. (2004). Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat. Diabetologia, 47 (1), 89-97. doi: 10.1007/s00125-003-1256-8
Osicka, Tanya M., Russo, Leileata M., Qiu, Mei-Lan, Brammar, Gail C., Thallas, Vicki, Forbes, Josephine M., Comper, Wayne D. and Jerums, George (2003). Additive effects of hypertension and diabetes on renal cortical expression of PKC-α and -ε and α-tubulin but not PKC-β1 and -β2. Journal of Hypertension, 21 (12), 2399-2407. doi: 10.1097/00004872-200312000-00029
Rizkalla, Bizhoy, Forbes, Josephine M., Cooper, Mark E. and Cao, Zemin (2003). Increased renal vascular endothelial growth factor and angiopoietins by angiotensin II infusion is mediated by both AT1 and AT2 receptors. Journal of the American Society of Nephrology, 14 (12), 3061-3071. doi: 10.1097/01.ASN.0000099374.58607.C9
Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease
Jerums, George, Panagiotopoulos, Sianna, Forbes, Josephine, Osicka, Tanya and Cooper, Mark (2003). Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease. Archives of Biochemistry And Biophysics, 419 (1), 55-62. doi: 10.1016/j.abb.2003.08.017
Ramipril prevents microtubular changes in proximal tubules from streptozotocin diabetic rats
Osicka, Tanya M., Forbes, Josephine M., Thallas, Vicki, Brammar, Gail C., Jerums, George and Comper, Wayne D. (2003). Ramipril prevents microtubular changes in proximal tubules from streptozotocin diabetic rats. Nephrology, 8 (4), 205-211. doi: 10.1046/j.1440-1797.2003.00159.x
Role of advanced glycation end products in diabetic nephropathy
Forbes, Josephine M., Cooper, Mark E., Oldfield, Matthew D. and Thomas, Merlin C. (2003). Role of advanced glycation end products in diabetic nephropathy. Journal of the American Society of Nephrology, 14 (suppl 3), S254-S258. doi: 10.1097/01.ASN.0000077413.41276.17
Reduced tubular cation transport in diabetes: prevented by ACE inhibition
Thomas, Merlin C., Tikellis, Chris, Burns, Wendy C., Thallas, Vicki, Forbes, Josephine M., Cao, Zemin, Osicka, Tanya M., Russo, Leileata M., Jerums, George, Ghabrial, Hany, Cooper, Mark E. and Kantharidis, Phillip (2003). Reduced tubular cation transport in diabetes: prevented by ACE inhibition. Kidney International, 63 (6), 2152-2161. doi: 10.1046/j.1523-1755.2003.00006.x
Candido, Riccardo, Forbes, Josephine M., Thomas, Merlin C., Thallas, Vicki, Dean, Rachael G., Burns, Wendy C., Tikellis, Christos, Ritchie, Rebecca H., Twigg, Stephen M., Cooper, Mark E. and Burrell, Louise M. (2003). A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes. Circulation Research, 92 (7), 785-792. doi: 10.1161/01.RES.0000065620.39919.20
Characterization of renal angiotensin - converting enzyme 2 in diabetic nephropathy
Tikellis, Christos, Johnston, Colin I., Forbes, Josephine M., Burns, Wendy C., Burrell, Louise M., Risvanis, John and Cooper, Mark E. (2003). Characterization of renal angiotensin - converting enzyme 2 in diabetic nephropathy. Hypertension, 41 (3), 392-397. doi: 10.1161/01.HYP.0000060689.38912.CB
Clavant, Steven P., Forbes, Josephine M., Thallas, Vicki, Osicka, Tanya M., Jerums, George and Comper, Wayne D. (2003). Reversible angiotensin II-mediated albuminuria in rat kidneys is dynamically associated with cytoskeletal organization. Nephron, 93 (2), 51-60. doi: 10.1159/000068528
Forbes, Josephine M, Thallas, Vicki, Thomas, Merlin C, Founds, Hank W, Burns, Wendy C, Jerums, George and Cooper, Mark E (2003). The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17 (12), 1762-1764.
Forbes, J. M., Cooper, M. E., Thallas, V., Burns, W. C., Thomas, M. C., Brammar, G. C., Lee, F., Grant, S. L., Burrell, L. A., Jerums, G. and Osicka, T. M. (2002). Erratum: Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy (Diabetes (2000) 51 (3274-3282)). Diabetes, 51 (12)
Twigg, Stephen M., Cao, Zemin, McLennan, Sue V., Burns, Wendy C., Brammar, Gail, Forbes, Josephine M. and Cooper, Mark E. (2002). Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology, 143 (12), 4907-4915. doi: 10.1210/en.2002-220619
Forbes, Josephine M., Cooper, Mark E., Thallas, Vicki, Burns, Wendy C., Thomas, Merlin C., Brammar, Gail C., Lee, Fiona, Grant, Sharon L., Burrell, Louise M., Jerums, George and Osicka, Tanya M. (2002). Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy. Diabetes, 51 (11), 3274-3282. doi: 10.2337/diabetes.51.11.3274
Forbes, Josephine M., Bonnet, Fabrice, Russo, Leileata M., Burns, Wendy C., Cao, Zemin, Candido, Riccardo, Kawachi, Hiroshi, Allen, Terri J., Cooper, Mark E., Jerums, George and Osicka, Tanya M. (2002). Modulation of nephrin in the diabetic kidney: association with systemic hypertension and increasing albuminuria. Journal of Hypertension, 20 (5), 985-992. doi: 10.1097/00004872-200205000-00034
Oldfield, MD, Bach, LA, Forbes, JM, Nikolic-Paterson, D, McRobert, A, Thallas, V, Atkins, RC, Osicka, T, Jerums, G and Cooper, ME (2001). Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). Journal of Clinical Investigation, 108 (12), 1853-1863. doi: 10.1172/jci11951
Forbes, Josephine Maree, Hewitson, Timothy David, Becker, Gavin James and Jones, Colin Lindsay (2001). Simultaneous blockade of endothelin A and B receptors in ischemic acute renal failure is detrimental to long-term kidney function. Kidney International, 59 (4), 1333-1341. doi: 10.1046/j.1523-1755.2001.0590041333.x
Endothelin and endothelin A/B receptors are increased after ischaemic acute renal failure
Forbes, JM, Jandeleit-Dahm, K, Allen, TJ, Hewitson, TD, Becker, GJ and Jones, CL (2001). Endothelin and endothelin A/B receptors are increased after ischaemic acute renal failure. Experimental Nephrology, 9 (5), 309-316.
Renoprotective effects of a novel inhibitor of advanced glycation
Forbes, J. M., Soulis, T., Thallas, V., Panagiotopoulos, S., Long, D. M., Vasan, S., Wagle, D., Jerums, G. and Cooper, M. E. (2001). Renoprotective effects of a novel inhibitor of advanced glycation. Diabetologia, 44 (1), 108-114. doi: 10.1007/s001250051587
Ischemic acute renal failure: long-term histology of cell and matrix changes in the rat
Forbes, Josephine M., Hewitson, Timothy D., Becker, Gavin J. and Jones, Colin L. (2000). Ischemic acute renal failure: long-term histology of cell and matrix changes in the rat. Kidney International, 57 (6), 2375-2385. doi: 10.1046/j.1523-1755.2000.00097.x
Cao, ZM, Kelly, DJ, Cox, A, Casley, D, Forbes, JM, Martinello, P, Dean, R, Gilbert, RE and Cooper, ME (2000). Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis. Kidney International, 58 (6), 2437-2451. doi: 10.1046/j.1523-1755.2000.00427.x
Cooper, ME, Thallas, V, Forbes, J, Scalbert, E, Sastra, S, Darby, I and Soulis, T (2000). The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation. Diabetologia, 43 (5), 660-664. doi: 10.1007/s001250051355
Forbes, Josephine M., Leaker, Brian, Hewitson, Tim D., Becker, Gavin J. and Jones, Colin L. (1999). Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists. Kidney International, 55 (1), 198-208. doi: 10.1046/j.1523-1755.1999.00253.x
Tissue Inhibitor of the Metalloproteinases and Renal Extracellular-Matrix Accumulation
Jones, CL, Fecondo, J, Kelynack, K, Forbes, J, Walker, R and Becker, G (1995). Tissue Inhibitor of the Metalloproteinases and Renal Extracellular-Matrix Accumulation. Experimental Nephrology, 3 (2), 80-86.
Kassianos, Andrew J., Giuliani, Kurt, Nag, Purba, Hong, Seokchan, Wang, Xiangju, Johnston, Rebecca L., Adams, Benjamin, Grivei, Anca, Ho, Kenneth, Ng, Monica, Waddell, Nicola, Forbes, Josephine M., Healy, Helen and Kassianos, Andrew J. (2023). Hypoxia and interleukin (IL)-1β synergistically induce cellular senescence in human proximal tubular epithelial cells (PTEC). 58th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Christchurch, New Zealand, 4-6 September 2023. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14216
Sullivan, Mitchell, Pham, Uyen, McCarthy, Domenica, Flemming, Nicole, Fotheringham, Amelia, Chandrashekar, Preeti, Whiddett, Rani, Buckle, Irina, Summers, Kim, Hodson, Mark, de Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasedale, Stephanie, Doomun, Sheik, de Souza, David, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Coughlan, Melinda, Johnson, David, O'Moore-Sullivan, Trisha, Barret, Helen, Marcovecchio, M. Loredana, Donaghue, Kim and Forbes, Josephine (2023). Youth with type 1 diabetes at higher risk of developing diabetic kidney disease have alterations in their urine and plasma metabolomic and mitochondrial dna profiles. 58th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Christchurch, New Zealand, 4-6 September 2023. Richmond, VIC Australia: John Wiley & Sons.
Mitochondrial dysfunction aligns with risk for diabetic kidney disease in youth with type 1 diabetes
Sullivan, Mitchell, McCarthy, Domenica, Flemming, Nicole, Chandrashekar, Preeti, Hodson, Mark, Fotheringham, Amelia, Whiddett, Rani, De Silva, Neisha, Nisbet, Jinelle, Morton, Adam, Teasdale, Stephanie, Isbel, Nicole, Jones, Timothy, Couper, Jennier, Thorburn, David, Johnson, David, Cotterill, Andrew, Barrett, Helen, O'Moore-Sullivan, Trisha, Donaghue, Kim and Forbes, Josephine (2022). Mitochondrial dysfunction aligns with risk for diabetic kidney disease in youth with type 1 diabetes. 57th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Sydney, NSW, Australia, 17–19 October 2022. Richmond, VIC, Australia: John Wiley & Sons.
Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming
Coughlan, M. T., Tan, S., Ziemann, M., Snelson, M., El-Osta, A., MacIsaac, R. J., Meikle, P. J., Forbes, J. M., Cooper, M. E., Ekinci, E. I. and Woodruff, T. M. (2019). Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming. 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona Spain, 16-20 September 2019. Heidelberg, Germany: Springer.
Fotheringham, A. K., Bagger, J. I., Borg, D. J., McCarthy, D., Vilsboll, T., Knop, F. K. and Forbes, J. M. (2019). Exploring AGE and sRAGE regulation in response to oral and intravenous glucose loads in individuals with recently diagnosed type 2 diabetes. 55th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 16-20 September 2019 . New York, NY, United States: Springer.
GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?
Sullivan, M. A., Wang, Z., Li, I., Milton, L., Mccarthy, D., Harcourt, B. E., Penfold, S. and Forbes, J. M. (2018). GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?. HOBOKEN: WILEY.
Lamb, Lydia, Alfonso, Helman, Norman, Paul E., Davis, Timothy M. E., Forbes, Josephine, Muench, Gerald and Yeap, Bu B. (2018). Circulating advanced glycation end products and their endogenous secretory receptor are associated with bone turnover markers and with incidence of hip fracture in older men. Joint Annual Scientific Meetings of Endocrine-Society-of-Australia (ESA) and Society-for-Reproductive-Biology (SRB), Perth Australia, Aug 27-30, 2017. HOBOKEN: WILEY.
Nutrition support and glycaemic variability in critically ill patients
Doola, R., Hurford, R., Flatley, C., Greer, R. M., Forbes, J. M., Todd, A. S., Joyce, C. J. and Sturgess, D. J. (2018). Nutrition support and glycaemic variability in critically ill patients. 40th ESPEN Congress, Madrid, Spain, 1-4 September 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.clnu.2018.06.1623
The role of GLUT4 in the kidney proximal tubule in blood glucose control and kidney function
Gallo, L. A., Gandhi, M. R., Abel, E. D., Rubera, I., Tauc, M. and Forbes, J. M. (2017). The role of GLUT4 in the kidney proximal tubule in blood glucose control and kidney function. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon Portugal, Sep 11-15, 2017. NEW YORK: SPRINGER.
Fotheringham, A. K., Solon-Biet, S. M., Mcmahon, A. C., Ballard, W. O., Ruohonen, K., Borg, D. J., Raubenheimer, D., Le Couteur, D. G., Simpson, S. J. and Forbes, J. M. (2017). Using the Geometric Framework to Explore the Longitudinal Effects of Dietary Macronutrient Consumption On Markers of Kidney Aging. HOBOKEN: WILEY.
Forbes, J. M., Flemming, N. B., Mccarthy, D. A., Boot, K., De Silva, N., Gallo, L. A., Nisbett, J., Morton, A., Teasdale, S., Thorburn, D. R., Russell, A., Isbel, N., Johnson, D., Morahan, G., Jones, T., Couper, J., Donaghue, K., Hodson, M. P. and O'Moore-Sullivan, T. (2017). Mitochondrial dysfunction defines a population of young people with type 1 diabetes at risk of kidney disease. 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD), Lisbon, Portugal, 11-15 September 2017. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia.
Forbes, J. M., Flemming, N., McCarthy, D., Boot, K., D'Silva, N., Gallo, L., Thorburn, D. R., Russell, A., Johnson, D., Morahan, G., Jones, T., Couper, J., Donaghue, K., Hodson, M. and O'Moore-Sullivan, T. (2017). Mitochondrial dysfunction defines a population of young people with type 1 diabetes at risk of kidney disease. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon Portugal, 11-15 September 2017. New York NY United States: Springer.
Understanding Novel Genetic Factors Underlying Circulating Cystatin C and Kidney Function
Fotheringham, A., Balmer, L., Morahan, G. and Forbes, J. (2016). Understanding Novel Genetic Factors Underlying Circulating Cystatin C and Kidney Function. HOBOKEN: WILEY-BLACKWELL.
IL-22-mediated suppression of islet inflammation
McGuckin, Mike, Hasnain, Sumaira Z., Borg, Danielle J., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathon P., Forbes, Josephine M. and Prins, John B. (2015). IL-22-mediated suppression of islet inflammation. IPITA/IXA/CTS Joint Congress, Melbourne Australia, Nov 15-19, 2015. HOBOKEN: LIPPINCOTT WILLIAMS & WILKINS.
Leung, S. S.-Y., Borg, D. J., McCarthy, D., Zhuang, A., Fotheringham, A., Di Trapani, G., Groop, P.-H., Knip, M. and Forbes, J. (2015). Human soluble receptor for advanced glycation end products therapy reduces autoimmune diabetes in the non-obese diabetic mouse. Joint Annual Conference of the International Society for Pediatric and Adolescent Diabetes and Australasian Paediatric Endocrine Group (ISPAD+APEG 2015), Brisbane, QLD Australia, 7-10 October 2015. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1111/pedi.12309
Leung, Sherman S., Borg, Danielle J., Paul, Moumita, Sharland, Alexandra F. and Forbes, Josephine M. (2015). Gene Therapy Using Recombinant Adeno-Associated Virus Serotype 2/8 Liver-Directed Expression of Srage in Experimental Type 1 Diabetes. 9th Biennial Meeting of the Australasian-Gene-and-Cell-Therapy-Society (AGCTS), Parkville, VIC Australia, 29 April - 1 May 2015. Hoboken, NJ United States: Wiley-Blackwell.
Leung, Sherman, Borg, Danielle J., McCarthy, Domenica, Zhuang, Aowen, Forbes, Josephine and Ward, Micheal (2015). Recombinant human soluble receptor for advanced glycation end product therapy reduces autoimmune diabetes in the NOD mouse model. 75th Scientific Sessions of the American-Diabetes-Association, Boston, MA USA, 5-9 June 2015. Alexandria, VA USA: American Diabetes Association.
Borg, D. J., Leung, S., Zhuang, A., Fotheringham, A., McCarthy, D., Di Trapani, J., Groop, P. -H., Knip, M. and Forbes, J. (2015). Delivery of recombinant human soluble receptor for advanced glycation end products delays autoimmune diabetes in the NOD mouse model. 51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Stockholm, Sweden, 14-18 September 2015. Heidelberg, Germany: Springer. doi: 10.1007/s00125-015-3687-4
IL-22-MEDIATED SUPPRESSION OF ISLET INFLAMMATION
McGuckin, Mike, Hasnain, Sumaira Z., Borg, Danielle J., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathon P., Forbes, Josephine M. and Prins, John B. (2015). IL-22-MEDIATED SUPPRESSION OF ISLET INFLAMMATION. Joint Congress of the International-Pancreas-and-Islet-Transplantation-Association, International-Xenotransplantation-Association and Cell-Transplant-Society, Melbourne Australia, Nov 15-19, 2015. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
In Db/db mice, Sglt2 inhibition does not improve diabetic nephropathy despite glycaemic improvements
Gallo, L. A., Ward, M. S., Fotheringham, A. K., Pollock, C., Panchapakesan, U. and Forbes, J. M. (2015). In Db/db mice, Sglt2 inhibition does not improve diabetic nephropathy despite glycaemic improvements. 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12543
Short-term alagebrium chloride (ALT-711) therapy pre-diabetes for the treatment of Type I Diabetes
Borg, D. J., McCarthy, D., Reeves, P., Ward, M. S., Fotheringham, A. K., Gallo, L. A., Harcourt, B. E., Agrawal, N., Steptoe, R. and Forbes, J. M. (2015). Short-term alagebrium chloride (ALT-711) therapy pre-diabetes for the treatment of Type I Diabetes. Immunology of Diabetes Society 14th International Congress, Munich, Germany, 12-16 April 2015.
Synbiotic Therapy in Pre-Dialysis: a Randomised Controlled Trial
Rossi, Megan, Johnson, David, Pascoe, Elaine, Coombes, Jeff, Forbes, Josephine, Szeto, Cheuk-Chun, McWhinney, Brett, Ungerer, Jacobus and Campbell, Katrina (2015). Synbiotic Therapy in Pre-Dialysis: a Randomised Controlled Trial. 52nd Congress of the European-Renal-Association-European-Dialysis-and-Transplant-Assocation, London England, 28-31 May 2015. United Kingdom: Oxford University Press. doi: 10.1093/ndt/gfv152.2
Leung, C., Herath, C. B., Zhiyuan, J., Leong, T., Forbes, J. M. and Angus, P. W. (2014). Manipulation of dietary advanced glycation end-product content influences the progression of non-alcoholic fatty liver disease (NAFLD). HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.12794
Zhuang, A., Sourris, K. C, Harcourt, B. E, Penfold, S. A., Fotheringham, A. K., McCarthy, D., Schulz, B. and Forbes, J. M. (2014). Ager1 overexpression in glomerular podocytes results in renal disease which is exacerbated by diabetes. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne VIC, Australia, 25 - 27 August 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301
Deficiency of rage in bone marrow cells reduces renal injury in diabetic mice
Tesch, G. H., Sourris, K. C., Summers, S. A., Mccarthy, D., Ward, M. S., Borg, D. J., Gallo, L. A., Fotheringham, A. K., Pettit, A., Yap, F. Y. T., Harcourt, B. E., Tan, A. L. Y., Kausman, J. Y., Nikolic-Paterson, D. J., Kitching, A. R. and Forbes, J. M. (2014). Deficiency of rage in bone marrow cells reduces renal injury in diabetic mice. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301
Leung, C., Fotheringham, A. K., Zhuang, A., Borg, D. J., Ward, M. S., Coughlan, M. T., Mccarthy, D. A., Gallo, L. A., Harcourt, B. E. and Forbes, J. M. (2014). Flux of advanced glycation end products across the kidney as a contributor to renal disease in diabetes. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne, Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12302
Gallo, Linda A., Ward, Micheal S., Harcourt, Brooke E., Fotheringham, Amelia K., McCarthy, Domenica A., Penfold, Sally A. and Forbes, Josephine M. (2014). Glyoxalase-1 Inhibition Leads to Podocyte Insulin Resistance and Features Resembling Diabetic Kidney Disease. 14th Asian Pacific Congress of Nephrology, Tokyo, Japan, 14-17 May 2014. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/nep.12236
Mitochondrial targeting of superoxide by Mitoq improves metabolic renal dysfunction
Ward, M. S., Flemming, N. B., Gallo, L. A., Fotheringham, A., Gobe, G., Vesey, D. and Forbes, J. M. (2014). Mitochondrial targeting of superoxide by Mitoq improves metabolic renal dysfunction. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301
Forbes, Josephine M., Harris, David C. H. and Cooper, Mark E. (2013). Report on ISN Forefronts, Melbourne, Australia, 4-7 October 2012: tubulointerstitial disease in diabetic nephropathy. New York, NY, United States: Elsevier. doi: 10.1038/ki.2013.89
Type 2 diabetes mellitus and brain atrophy - the role of advanced glycation end-products
Moran, C., Muench, G., Beare, R., Blizzard, L., Venn, A., Phan, T., Forbes, J. and Srikanth, V (2013). Type 2 diabetes mellitus and brain atrophy - the role of advanced glycation end-products. HOBOKEN: WILEY-BLACKWELL.
Methylglyoxal induced insulin resistance in podocytes contributes to diabetic kidney disease
Gallo, L. A., Harcourt, B. E., Fotheringham, A. K., McCarthy, D., Penfold, S. A. and Forbes, J. M. (2013). Methylglyoxal induced insulin resistance in podocytes contributes to diabetic kidney disease. 49th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 23 -27 September 2013. Heidelberg, Germany: Springer. doi: 10.1007/s00125-013-3012-z
Oligosaccharyltransferase-48 as a Novel Mediator of Chronic Kidney Disease in Diabetes
Zhuang, A., Harcourt, B., Sourris, K., Penfold, S., Ward, M., Fotheringham, A., Thorn, P. and Forbes, J. (2013). Oligosaccharyltransferase-48 as a Novel Mediator of Chronic Kidney Disease in Diabetes. WILEY-BLACKWELL.
Borg, D. J., Yap, F. Y. T., Fotheringham, A. K., Harcourt, B. E., McCarthy, D., Ward, M., Slattery, R., Coughlan, M. T., Kantharidis, P. and Forbes, J. M. (2013). Therapies which lower advanced glycation end products influence experimental autoimmune diabetes in a time dependent manner. 49th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 23 -27 September 2013. Heidelberg, Germany: Springer. doi: 10.1007/s00125-013-3012-z
Regulation of Renal Receptor for Advanced Glycation End Products (Rage) Via Paracrine Estrogens
Harcourt, B. E., Coughlan, M. T., Andrikopoulos, S., Thomas, M. C., Bruce, C., Febbraio, M. A., Nawroth, P., Bierhaus, A., Kantharidis, P., Cooper, M. E. and Forbes, J. M. (2011). Regulation of Renal Receptor for Advanced Glycation End Products (Rage) Via Paracrine Estrogens. WILEY-BLACKWELL.
Ubiquinone Is Renoprotective in An Experimental Model of Type 2 Diabetes
Sourris, K. C., Morley, A. L., Harcourt, B. E., Penfold, S. A., Coughlan, M. T., Nugyen, T-V, Cooper, M. E., Ritchie, R. H. and Forbes, J. M. (2011). Ubiquinone Is Renoprotective in An Experimental Model of Type 2 Diabetes. WILEY-BLACKWELL.
The pathogenic potential of different sized age modified molecules via rage signalling pathways
Penfold, S. A., Sourris, K. C., Coughlan, M. T., Tan, A. L., Kaye, D. M., Cooper, M. E. and Forbes, J. M. (2010). The pathogenic potential of different sized age modified molecules via rage signalling pathways. International Symposium on the The Maillard Reaction, Palm Cove, QLD, Australia, 29-31 August 2009. Cambridge, United Kingdom: Royal Society of Chemistry.
Sourris, K. C. and Forbes, J. M. (2010). The renin-angiotensin system and advanced glycation end-products in diabetic nephropathy how important are these pathways as therapeutic targets?. Royal Society of Chemistry.
High Density Lipoprotein Modulates Glucose Metabolism by Multiple Mechanisms
Drew, Brian G., Duffy, Stephen J., Forbes, Josephine M., Chin-Dusting, Jaye, Kaye, David M., Kemp, Bruce E., Sviridov, Dmitri, Steinberg, Gregory R. and Kingwell, Bronwyn A. (2009). High Density Lipoprotein Modulates Glucose Metabolism by Multiple Mechanisms. 82nd Scientific Session of the American-Heart-Association, Orlando Fl, Nov 14-18, 2009. LIPPINCOTT WILLIAMS & WILKINS.
De Courten, Barbora, De Courten, Maximilian P. J., Dougherty, Sonia, Woollard, Kevin J., Cooper, Mark E., Kingwell, Bronwyn A., Forbes, Josephine M., Potts, Jenna R. and Considine, Robert V. (2009). Plasma Hepatocyte Growth Factor (HGF) Is Inversely Associated with Insulin Sensitivity in Healthy Humans. 69th Annual Meeting of the American-Diabetes-Association, New Orleans La, Jun 05-09, 2009. AMER DIABETES ASSOC.
Sourris, K. C., Mibus, A. L., Koitka, A., Harcourt, B. E., Tan, A. L. Y., Cooper, M. E. and Forbes, J. M. (2008). Interaction between the renin-angiotensin system (RAS) and advanced glycation end products (AGES) in the development of diabetic nephropathy. SPRINGER.
Coughlan, Melinda T., Mibus, Amy L., Tan, Adeline L., Harcourt, Brooke E., Sourris, Karly C., Penfold, Sally A., Thallas-Bonke, Vicki, Yap, Felicia Y., Gasser, Anna, Thomas, Merlin, Su, Qing, Bierhaus, Angelika, Cooper, Mark E. and Forbes, Josephine M. (2008). The renal pathogenicity of dietary glycotoxins is mediated via the receptor for advanced glycation end products (RAGE). 67th Annual Meeting of the American-Diabetes-Association, San Francicso Ca, Jun 06-10, 2008. AMER DIABETES ASSOC.
Coughlan, Melinda T., Penfold, Sally A., Cooper, Mark E., Panagiotopoulos, Sianna, Macisaac, Richard J., Jerums, George and Forbes, Josephine M. (2008). Urinary, but not serum levels of the AGE, n-carboxymethyl-lysine are associated with progressive nephropathy in patients with type 1 and type 2 diabetes. 67th Annual Meeting of the American-Diabetes-Association, San Francicso Ca, Jun 06-10, 2008. AMER DIABETES ASSOC.
Oxidative stress and advanced glycation in diabetic nephropathy
Coughlan, Melinda T., Mibus, Amy L. and Forbes, Josephine M. (2008). Oxidative stress and advanced glycation in diabetic nephropathy. The 9th International Symposium on the Maillard Reaction, Munich, Germany, 1-5 September 2007. Malden, MA, United States: Wiley-Blackwell Publishing. doi: 10.1196/annals.1433.018
Therapeutic interruption of advanced glycation in diabetic nephropathy: do all roads lead to Rome?
Sourris, Karly C., Forbes, Josephine M. and Cooper, Mark E. (2008). Therapeutic interruption of advanced glycation in diabetic nephropathy: do all roads lead to Rome?. The 9th International Symposium on the Maillard Reaction, Munich, Germany, 1-5 September 2007. Malden, MA, United States: Wiley-Blackwell Publishing. doi: 10.1196/annals.1433.048
Harcourt, B. E., Mibus, A., Gasser, A., Andikopoulos, S., Thomas, M., Coughlan, M. T., Sourris, K., Rice, G., Bierhaus, A., Cooper, M. E. and Forbes, J. M. (2007). Interaction between the receptor for advanced glycation end products (RAGE) and estrone (E1) in the development of type 2 diabetic nephropathy. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam Netherlands, Sep 18-21, 2007. SPRINGER.
Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes
Coughlan, M. T., Forbes, J. M. and Cooper, M. E. (2007). Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes. 5th Hyonam-Kidney-Laboratory-International-Diabetes Symposium, Seoul South Korea, Feb 02-03, 2007. Nature Publishing Group. doi: 10.1038/sj.ki.5002387
Diabetes-induced effects on endothelial function and the actions of nitric oxide
Soro-Paavonen, A., Zhang, W. -Z., Venardos, K., Jones, E., Chin-Dusting, J., Thomas, M. T., Coughlan, M. T., Brasacchio, D., Cooper, M. E., Kaye, D. and Forbes, J. M. (2006). Diabetes-induced effects on endothelial function and the actions of nitric oxide. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen Denmark, Sep 14-17, 2006. SPRINGER.
Advanced glycation end products and diabetic nephropathy
Thomas, Merlin C., Forbes, Josephine M. and Cooper, Mark E. (2005). Advanced glycation end products and diabetic nephropathy. doi: 10.1097/01.mjt.0000178769.52610.69
Coughlan, Melinda T., Cooper, Mark E. and Forbes, Josephine M. (2005). Can advanced glycation end product inhibitors modulate more than one pathway to enhance renoprotection in diabetes?. New York Academy of Sciences. doi: 10.1196/annals.1333.087
Direct anti-atherogenic properties of PPAR alpha and PPAR gamma agonists
Cooper, ME, Forbes, JM, Smith, CM, Lassila, M, Jandeleit-Dahm, KA, Allen, TJ and Calkin, AC (2005). Direct anti-atherogenic properties of PPAR alpha and PPAR gamma agonists. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Athens Greece, Sep 10-15, 2005. SPRINGER.
Forbes, JM, Coughlan, MT, Fukami, K, Laskowski, A, Thallas-Bonke, V, Dinh, D, Long, DM, Brownlee, M, Cooper, ME and Thorburn, DR (2005). Do extracellular (circulating or dietary) advanced glycation end products mediate mitochondrial dysfunction in the kidney?. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Athens Greece, Sep 10-15, 2005. SPRINGER.
Low-molecular weight advanced glycation end products: Markers of tissue AGE accumulation and more?
Thomas, Merlin C., Forbes, Josephine M., MacIsaac, Richard, Jerums, George and Cooper, Mark E. (2005). Low-molecular weight advanced glycation end products: Markers of tissue AGE accumulation and more?. New York Academy of Sciences. doi: 10.1196/annals.1333.073
Coughlan, MT, Thorburn, DR, Fukami, K, Laskowski, A, Thallas-Bonke, V, Long, DM, Brownlee, M, Cooper, ME and Forbes, JM (2005). Renal intra-mitochondrial glycation drives deficiencies in the activity of manganese superoxide dismutase and complex I of the mitochondrial respiratory chain in diabetes. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Athens Greece, Sep 10-15, 2005. SPRINGER.
Jandeleit-Dahm, KAM, Lassila, M, Seah, KK, Allen, TJ, Thallas, V, Thomas, MC, Candido, R, Burns, WC, Forbes, JM, Calkin, AC and Cooper, ME (2004). Inhibitors of advanced glycation end product accumulation ameliorate renal injury in the diabetic apoE knockout mouse. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Munich Germany, Sep 05-09, 2004. SPRINGER.
Boner, G, Thallas, V, Cooper, ME, Rizkalla, B, Qui, ML and Forbes, JM (2003). Interference with advanced glycation end-products (AGEs) attenuates extracellular matrix (ECM) accumulation in diabetic nephropathy via protein kinase C (PKC) dependent pathways.. 36th Annual Meeting of the American-Society-of-Nephrology, San Diego California, Nov 12-17, 2003. LIPPINCOTT WILLIAMS & WILKINS.
Allen, TJ, Forbes, JM, Yee, LT, Thallas, V, Thomas, MC, Candido, R, Jandeleit-Dahm, KA and Cooper, ME (2003). Attenuation of diabetes associated atherosclerosis with the advanced glycation end product cross-link breaker, ALT-711. 76th Annual Scientific Session of the American-Heart-Association, Orlando Florida, Nov 07-12, 2003. LIPPINCOTT WILLIAMS & WILKINS.
Pivotal role of the AT2 receptor subtype in mediating angiotensin II indiced renal VEGF expression.
Rizkalla, BM, Cao, ZM, Forbes, JM and Cooper, ME (2002). Pivotal role of the AT2 receptor subtype in mediating angiotensin II indiced renal VEGF expression.. LIPPINCOTT WILLIAMS & WILKINS.
Renoprotection is afforded by the advanced glycation end product (AGE) cross-link breaker, ALT-711.
Forbes, JM, Thallas, V, Jerums, G, Thomas, MC and Cooper, ME (2002). Renoprotection is afforded by the advanced glycation end product (AGE) cross-link breaker, ALT-711.. LIPPINCOTT WILLIAMS & WILKINS.
Cooper, ME, Cao, Z, Candido, R, Forbes, JM, Osicka, TM, Twigg, S and Bonnet, F (2002). Expression of connective tissue growth factor in the diabetic kidney: association with renal collagen synthesis.. 38th EASD Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Budapest Hungary, Sep 01-05, 2002. SPRINGER-VERLAG.
Davis, BJ, Forbes, JM, Jerums, G, Cooper, ME and Allen, TJ (2002). Does combined blockade of RAS and advanced glycation end-product formation confer superior renoprotection in a hypertensive model of diabetic nephropathy?. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting, Prague Czech Republic, Jun 23-27, 2002. LIPPINCOTT WILLIAMS & WILKINS.
Twigg, SM, Cao, Z, Burns, WC, Brammar, G, Forbes, JM and Cooper, ME (2002). Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. AMER DIABETES ASSOC.
Artificial activation of matrix metalloproteinases.
Jones, CI, Forbes, JM, Walker, RG and Becker, GJ (1997). Artificial activation of matrix metalloproteinases.. BLACKWELL SCIENCE INC.
Activation of renal type IV collagenases.
Jones, CL, Forbes, JM, Walker, RG and Becker, GJ (1996). Activation of renal type IV collagenases.. AMER SOC NEPHROLOGY.
Designing and translating novel therapies for diabetes and kidney disease
(2022–2026) NHMRC Investigator Grants
Innovative delivery methods for the biologic soluble RAGE to prevent Type 1 Diabetes
(2021–2024) JDRF Pilot and Innovation Awards
Preventing progression of diabetic kidney disease by targeting mitochondrial function
(2019–2021) NHMRC Project Grant
RAGE as a novel therapeutic target for T1D
(2019–2021) Juvenile Diabetes Research Foundation - International
Dissolution DNP Hyperpolariser
(2019) UQ Research Facilities Infrastructure Grants
Investigating pathways to alleviate the burden of diabetes and kidney disease
(2016–2020) NHMRC Research Fellowship
(2016–2018) University of Miami
(2016–2017) Augusta University
Mitochondrial dysfunction as a mediator of diabetic kidney disease
(2016) Diabetes Australia Research Program
IL-22 as a Suppressor of Pancreatic Beta-Cell Stress and a Treatment for Diabetes
(2015–2019) NHMRC Project Grant
(2015–2018) University of Adelaide
(2015–2017) Augusta University
Glucose transport in the diabetic kidney
(2015) Diabetes Australia Research Trust
Urinary metabolic profiles as predictors of early diabetic nephropathy
(2014–2016) Kidney Health Australia
(2013–2015) NHMRC Research Fellowship
Identification of a novel target for the treatment of diabetic kidney disease
(2013–2014) NHMRC Project Grant
Modern food processing as a contributor to type 1 diabetes
(2013–2014) NHMRC Project Grant
Early mitochondrial dysfunction in diabetic kidney
Doctor Philosophy — Principal Advisor
Other advisors:
The receptor for advanced glycation end products and its role in Type 1 diabetes development
Doctor Philosophy — Principal Advisor
New insights into molecular pathways involved in the development of diabetic kidney disease: Towards earlier disease detection and identification of novel therapeutic targets
Doctor Philosophy — Principal Advisor
Other advisors:
Unravelling the role of abnormal glycogen accumulation in diabetic kidney disease
Doctor Philosophy — Associate Advisor
Other advisors:
The Characterisation of Immune Cells in Response To RAGE Antagonism Therapy in Mouse Models of Type 1 Diabetes
Doctor Philosophy — Associate Advisor
Other advisors:
Mitochondrial dysfunction as a pathological mediator in diabetic kidney disease
(2021) Doctor Philosophy — Principal Advisor
Other advisors:
Novel dietary factors in diabetic and non-diabetic kidney disease
(2020) Doctor Philosophy — Principal Advisor
Other advisors:
The role of receptor for advanced glycation end products (RAGE) in the development of type 1 diabetes
(2020) Doctor Philosophy — Principal Advisor
Other advisors:
(2018) Doctor Philosophy — Principal Advisor
Other advisors:
Kidneys on fire: The role of inflammasome signalling in human chronic kidney disease
(2023) Doctor Philosophy — Associate Advisor
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Nutritional management of hyperglycaemia in intensive care medicine
(2019) Doctor Philosophy — Associate Advisor
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