The University of Queensland

Non-coding RNAs in mammary gland development and disease

Sandhu, Gurveen K., Milevskiy, Michael J.G., Wilson, Wesley, Shewan, Annette M. and Brown, Melissa A. (2016). Non-coding RNAs in mammary gland development and disease. Non-coding RNA and the Reproductive System. (pp. 121-153) edited by Wilhelm, D and Bernard, P. New York, United States: Springer . doi: 10.1007/978-94-017-7417-8_7

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Johnson, Nichola, Maguire, Sarah, Morra, Anna, Kapoor, Pooja Middha, Tomczyk, Katarzyna, Jones, Michael E., Schoemaker, Minouk J., Gilham, Clare, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Ahearn, Thomas U., Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Arndt, Volker, Aronson, Kristan J., Augustinsson, Annelie, Baynes, Caroline, Freeman, Laura E. Beane, Beckmann, Matthias W., Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Boeckx, Bram, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann ... Fletcher, Olivia (2021). CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. British Journal of Cancer, 124 (4), 842-854. doi: 10.1038/s41416-020-01185-w

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fachal, Laura, Aschard, Hugues, Beesley, Jonathan, Barnes, Daniel R., Allen, Jamie, Kar, Siddhartha, Pooley, Karen A., Dennis, Joe, Michailidou, Kyriaki, Turman, Constance, Soucy, Penny, Lemaçon, Audrey, Lush, Michael, Tyrer, Jonathan P., Ghoussaini, Maya, Marjaneh, Mahdi Moradi, Jiang, Xia, Agata, Simona, Aittomäki, Kristiina, Alonso, M. Rosario, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Arason, Adalgeir, Arndt, Volker, Aronson, Kristan J., Arun, Banu K., Auber, Bernd, Auer, Paul L. ... Dunning, Alison M. (2020). Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nature Genetics, 52 (1), 56-73. doi: 10.1038/s41588-019-0537-1

Caution: plasmid DNA topology affects luciferase assay reproducibility and outcomes

Tudini, Emma, Burke, Lez J., Whiley, Phillip J., Sevcik, Jan, Spurdle, Amanda B. and Brown, Melissa A. (2019). Caution: plasmid DNA topology affects luciferase assay reproducibility and outcomes. BioTechniques, 67 (3), 94-96. doi: 10.2144/btn-2019-0060

Towards controlled terminology for reporting germline cancer susceptibility variants: An ENIGMA report

Spurdle, Amanda B., Greville-Heygate, Stephanie, Antoniou, Antonis C., Brown, Melissa, Burke, Leslie, De La Hoya, Miguel, Domchek, Susan, Dörk, Thilo, Firth, Helen V., Monteiro, Alvaro N., Mensenkamp, Arjen, Parsons, Michael T., Radice, Paolo, Robson, Mark, Tischkowitz, Marc, Tudini, Emma, Turnbull, Clare, Vreeswijk, Maaike P.G., Walker, Logan C., Tavtigian, Sean and Eccles, Diana M. (2019). Towards controlled terminology for reporting germline cancer susceptibility variants: An ENIGMA report. Journal of Medical Genetics, 56 (6), 347-357. doi: 10.1136/jmedgenet-2018-105872

MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer

Milevskiy, Michael J. G., Gujral, Udai, Del Lama Marques, Carolina, Stone, Andrew, Northwood, Korinne, Burke, Lez J., Gee, Julia M. W., Nephew, Kenneth, Clark, Susan and Brown, Melissa A. (2019). MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer. British Journal of Cancer, 120 (6), 621-632. doi: 10.1038/s41416-019-0395-8

Heritable DNA methylation marks associated with susceptibility to breast cancer

Joo, Jihoon E., Dowty, James G., Milne, Roger L., Wong, Ee Ming, Dugué, Pierre-Antoine, English, Dallas, Hopper, John L., Goldgar, David E., Giles, Graham G., Southey, Melissa C., kConFab, Sexton, Adrienne, Christian, Alice, Trainer, Alison, Spigelman, Allan, Fellows, Andrew, Shelling, Andrew, De Fazio, Anna, Blackburn, Anneke, Crook, Ashley, Meiser, Bettina, Patterson, Briony, Clarke, Christine, Saunders, Christobel, Hunt, Clare, Scott, Clare, Amor, David, Marsh, Deborah, Edkins, Edward ... Antill, Yoland (2018). Heritable DNA methylation marks associated with susceptibility to breast cancer. Nature Communications, 9 (1) 867. doi: 10.1038/s41467-018-03058-6

Non-coding variants in BRCA1 and BRCA2 genes: potential impact on breast and ovarian cancer predisposition

dos Santos, Elizabeth Santana, Lallemand, François, Burke, Leslie, Stoppa-Lyonnet, Dominique, Brown, Melissa, Caputo, Sandrine M. and Rouleau, Etienne (2018). Non-coding variants in BRCA1 and BRCA2 genes: potential impact on breast and ovarian cancer predisposition. Cancers, 10 (11) 453, 453. doi: 10.3390/cancers10110453

MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer

Milevskiy, Michael J. G., Sandhu, Gurveen K., Wronski, Anna, Korbie, Darren, Brewster, Brooke L., Shewan, Annette, Edwards, Stacey L., French, Juliet D. and Brown, Melissa A. (2018). MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer. Oncotarget, 9 (71), 33577-33588. doi: 10.18632/oncotarget.26094

BRCA1 and BRCA2 5′ noncoding region variants identified in breast cancer patients alter promoter activity and protein binding

Burke, Leslie J., Sevcik, Jan, Gambino, Gaetana, Tudini, Emma, Mucaki, Eliseos J., Shirley, Ben C., Whiley, Phillip, Parsons, Michael T., De Leeneer, Kim, Gutiérrez-Enríquez, Sara, Santamariña, Marta, Caputo, Sandrine M., Santana dos Santos, Elizabeth, Soukupova, Jana, Janatova, Marketa, Zemankova, Petra, Lhotova, Klara, Stolarova, Lenka, Borecka, Mariana, Moles-Fernández, Alejandro, Manoukian, Siranoush, Bonanni, Bernardo, Edwards, Stacey L., Blok, Marinus J., van Overeem Hansen, Thomas, Rossing, Maria, Diez, Orland, Vega, Ana, Claes, Kathleen B.M. ... ENIGMA Consortium (2018). BRCA1 and BRCA2 5′ noncoding region variants identified in breast cancer patients alter promoter activity and protein binding. Human Mutation, 39 (12), 2025-2039. doi: 10.1002/humu.23652

Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage

Betts, Joshua A., Moradi Marjaneh, Mahdi, Al-Ejeh, Fares, Lim, Yi Chieh, Shi, Wei, Sivakumaran, Haran, Tropee, Romain, Patch, Ann.-Marie, Clark, Michael B., Bartonicek, Nenad, Wiegmans, Adrian P., Hillman, Kristine M., Kaufmann, Susanne, Bain, Amanda L., Gloss, Brian S., Crawford, Joanna, Kazakoff, Stephen, Wani, Shivangi, Wen Shu W., Day, Bryan, Moller, Andreas, Cloonan, Nicole, Pearson,John, Brown, Melissa A., Mercer, Timothy R., Waddell, Nicola, Khanna, Kum Kum, Dray, Eloise, Dinger, Marcel E. ... French, Juliet D. (2017). Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage. American Journal of Human Genetics, 101 (2), 255-266. doi: 10.1016/j.ajhg.2017.07.007

Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer

Milevskiy, Michael J. G., Al-Ejeh, Fares, Saunus, Jodi M., Northwood, Korinne S., Bailey, Peter J., Betts, Joshua A., McCart Reed, Amy E., Nephew, Kenneth P., Stone, Andrew, Gee, Julia M. W., Dowhan, Dennis H., Dray, Eloise, Shewan, Annette M., French, Juliet D., Edwards, Stacey L., Clark, Susan J., Lakhani, Sunil R. and Brown, Melissa A. (2016). Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Human Molecular Genetics, 25 (15), 3269-3283. doi: 10.1093/hmg/ddw177

The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin

Peters, Amelia A., Milevskiy, Michael J. G., Lee, WeiC., Curry, Merril C., Smart, Chanel E., Saunus, Jodi M., Reid, Lynne, da Silva, Leonard, Marcial, Daneth L., Dray, Eloise, Brown, Melissa A., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin. Scientific Reports, 6 (1) 25505, 25505. doi: 10.1038/srep25505

MicroRNA-206 is differentially expressed in Brca1-deficient mice and regulates epithelial and stromal cell compartments of the mouse mammary gland

Wronski, A., Sandhu, G. K., Milevskiy, M. J., Brewster, B. L., Bridge, J. A., Shewan, A. M., Edwards, S. L., French, J. D. and Brown, M. A. (2016). MicroRNA-206 is differentially expressed in Brca1-deficient mice and regulates epithelial and stromal cell compartments of the mouse mammary gland. Oncogenesis, 5 (4) e218, e218.1-e218.9. doi: 10.1038/oncsis.2016.27

The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer

Pera, Elena, Kaemmerer, Elke, Milevskiy, Michael J. G., Yapa, Kunsala T. D. S., O'Donnell, Jake S., Brown, Melissa A., Simpson, Fiona, Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer. Cancer Cell International, 16 (24) 24, 24. doi: 10.1186/s12935-016-0299-0

No association between HPV positive breast cancer and expression of human papilloma viral transcripts

Gannon, Orla M., Antonsson, Annika, Milevskiy, Michael, Brown, Melissa A., Saunders, Nicholas A. and Bennett, Ian C. (2015). No association between HPV positive breast cancer and expression of human papilloma viral transcripts. Scientific Reports, 5 (18081) 18081, 18081. doi: 10.1038/srep18081

Methylome sequencing in triple negative breast cancer reveals distinct methylation clusters with prognostic value

Stirzaker, Clare, Zotenko, Elena, Song, Jenny Z., Qu, Wenja, Nair, Shalima, Locke, Warwick J., Stone, Andrew Stone, Armstrong, Nicola J., Robinson, Mark D., Dobrovic, Alexander, Avery-Kiejda, Kelly A., Peters, Kate M., French, Juliet D., Stein, Sandra, Korbie, Darren J., Trau, Matt, Forbes, John F., Scott, Rodney J., Brown, Melissa A., Francis, Glenn D. and Clark, Susan J. (2015). Methylome sequencing in triple negative breast cancer reveals distinct methylation clusters with prognostic value. Nature Communications, 6 (5899) 5899, 1-11. doi: 10.1038/ncomms6899

Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1

Glubb, Dylan, Maranian, Mel J., Michailidou, Kyriaki, Pooley, Karen A., Meyer, Kerstin, Kar, Siddhartha, Carlebur, Saskia, O'Reilly, Martin, Betts, Joshua A., Hillman, Kristine M., Kaufmann, Susanne, Beesley, Jonathan, Canisius, Sander, Hopper, John L., Southey, Melissa C., Tsimiklis, Helen, Apicella, Carmel, Schmidt, Marjanka K., Broeks, Annegien, Hogervorst, Frans B., van der Schoot, C. Ellen, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter, Ruebner, Matthias, Ekici, Arif B., Beckmann, Matthias W. ... French, Juliet D. (2015). Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. American Journal of Human Genetics, 96 (1), 5-20. doi: 10.1016/j.ajhg.2014.11.009

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Ghoussaini, Maya, Edwards, Stacey L., Michailidou, Kyriaki, Nord, Silje, Lari, Richard Cowper-Sal, Desai, Kinjal, Kar, Siddhartha, Hillman, Kristine M., Kaufmann, Susanne, Glubb, Dylan M., Beesley, Jonathan, Dennis, Joe, Bolla, Manjeet K., Wang, Qin, Dicks, Ed, Guo, Qi, Schmidt, Marjanka K., Shah, Mitul, Luben, Robert, Brown, Judith, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Klevebring, Daniel, Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Lambrechts, Diether ... Dunning, Alison M. (2014). Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nature Communications, 5 (1) 4999, 4999.1-4999.12. doi: 10.1038/ncomms5999

Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: a report from the ENIGMA consortium

Colombo, Mara, Blok, Marinus J., Whiley, Phillip, Santamarina, Marta, Gutierrez-Enriquez, Sara, Romero, Atocha, Garre, Pilar, Becker, Alexandra, Smith, Lindsay Denise, Vecchi, Giovanna De, Brandao, Rita D., Tserpelis, Demis, Brown, Melissa, Blanco, Ana, Bonache, Sandra, Menendez, Mireia, Houdayer, Claude, Foglia, Claudia, Fackenthal, James D., Baralle, Diana, Wappenschmidt, Barbara, Diaz-Rubio, Eduardo, Caldes, Trinidad, Walker, Logan, Diez, Orland, Vega, Ana, Spurdle, Amanda B., Radice, Paolo and de la Hoya, Miguel (2014). Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: a report from the ENIGMA consortium. Human Molecular Genetics, 23 (14) ddu075, 3666-3680. doi: 10.1093/hmg/ddu075

Comparison of mRNA splicing assay protocols across multiple laboratories: recommendations for best practice in standardized clinical testing

Whiley, Phillip J., De La Hoya, Miguel, Thomassen, Mads, Becker, Alexandra, Brandão, Rita, Sokilde Pedersen, Inge, Montagna, Marco, Menéndez, Mireia, Quiles, Francisco, Gutiérrez-Enríquez, Sara, De Leeneer, Kim, Tenés, Anna, Montalban, Gemma, Tserpelis, Demis, Yoshimatsu, Toshio, Tirapo, Carole, Raponi, Michela, Caldes, Trinidad, Blanco, Ana, Santamariña, Marta, Guidugli, Lucia, Ruiz de Garibay, Gorka, Wong, Ming, Tancredi, Mariella, Fachal, Laura, Chun Ding, Yuan, Kruse, Torben, Lattimore, Vanessa, Kwong, Ava ... Brown, Melissa A. (2014). Comparison of mRNA splicing assay protocols across multiple laboratories: recommendations for best practice in standardized clinical testing. Clinical Chemistry, 60 (2), 341-352. doi: 10.1373/clinchem.2013.210658

Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation

Whiley, Phillip J., Parsons, Michael T., Leary, Jennifer, Tucker, Kathy, Warwick, Linda, Dopita, Belinda, Thorne, Heather, Lakhani, Sunil R., Goldgar, David E., Brown, Melissa A. and Spurdle, Amanda B. (2014). Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation. PloS One, 9 (1) e86836, 1-10. doi: 10.1371/journal.pone.0086836

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

French, Juliet D., Ghoussaini, Maya, Edwards, Stacey L., Meyer, Kerstin B., Michailidou, Kyriaki, Ahmed, Shahana, Khan, Sofia, Maranian, Mel J., O'Reilly, Martin, Hillman, Kristine M., Betts, Joshua A., Carro, Thomas, Bailey, Peter J., Dicks, Ed, Beesley, Jonathan, Tyrer, Jonathan, Maia, Ana-Teresa, Beck, Andrew, Knoblauch, Nicholas W., Chen, Constance, Kraft, Peter, Barnes, Daniel, Gonzalez-Neira, Anna, Rosario Alonso, M., Herrero, Daniel, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Luccarini, Craig ... Dunning, Alison M. (2013). Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. American Journal of Human Genetics, 92 (4), 489-503. doi: 10.1016/j.ajhg.2013.01.002

Consequences of germline variation disrupting the constitutional translational initiation codon start sites of MLH1 and BRCA2: Use of potential alternative start sites and implications for predicting variant pathogenicity

Parsons, Michael T., Whiley, Phillip J., Beesley, Jonathan, Drost, Mark, de Wind, Neils, Thompson, Bryony A., Marquart, Lousie, Hopper, John L., Jenkins, Mark A., Brown, Melissa A., Tucker, Kathy, Warwick, Linda, Buchanan, Daniel D., Spurdle, Amanda B. and Australasian Colorectal Cancer Family Registry (2013). Consequences of germline variation disrupting the constitutional translational initiation codon start sites of MLH1 and BRCA2: Use of potential alternative start sites and implications for predicting variant pathogenicity. Molecular Carcinogenesis, 54 (7), 513-522. doi: 10.1002/mc.22116

eLCR: electrochemical detection of single DNA base changes via ligase chain reaction

Wee, Eugene J. H., Shiddiky, Muhammad J. A., Brown, Melissa A. and Trau, Matt (2012). eLCR: electrochemical detection of single DNA base changes via ligase chain reaction. Chemical Communications, 48 (98), 1214-1216. doi: 10.1039/C2CC35841G

Long-range transcriptional regulation of breast cancer genes

Betts, Joshua A., French, Juliet D., Brown, Melissa A. and Edwards, Stacey L. (2012). Long-range transcriptional regulation of breast cancer genes. Genes, Chromosomes and Cancer, 52 (2), 113-125. doi: 10.1002/gcc.22020

BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk

Spurdle, Amanda B., Whiley, Phillip J., Thompson, Bryony, Feng, Bingjian, Healey, Sue, Brown, Melissa A., Pettigrew, Christopher, kConFab, Van Asperen, Christi J., Ausems, Margreet G. E. M., Kattentidt-Mouravieva, Anna A., Pigg, Maritta H., Schmutzler, Rita K., Engel, Christoph, Meindl, Alfons, German Consortium of Hereditary Breast and Ovarian Cancer, Caputo, Sandrine, Sinilnikova, Olga M., Lidereau, Rosette, French COVAR group collaborators, Couch, Fergus J., Guidugli, Lucia, van Overeem Hansen, Thomas, Thomassen, Mads, Eccles, Diana M., Tucker, Kathy, Benitez, Javier, Domchek, Susan M., Toland, Amanda E. ... ENIGMA Consortium (2012). BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk. Journal of Medical Genetics, 49 (8), 525-532. doi: 10.1136/jmedgenet-2012-101037

Morphological and molecular analysis of a breast cancer cluster at the ABC Studio in Toowong

Waddell, N., Stein, S. R., Wagner, S. A., Bennett, I., Djougarian, A., Melana, S., Jaffer, S., Holland, J. F., Pogo, B. G. T., Gonda, T. J., Brown, M. A., Leo, P., Saunders, N. A., McMillan, N. A., Cocciardi, S., Vargas, A. C., Lakhani, S. R., Chenevix-Trench, G., Newman, B. and Francis, G. D. (2012). Morphological and molecular analysis of a breast cancer cluster at the ABC Studio in Toowong. Pathology, 44 (5), 469-472. doi: 10.1097/PAT.0b013e3283559e67

Protein arginine methyltransferase 6-dependent gene expression and splicing: Association with breast cancer outcomes

Dowhan, Dennis H., Harrison, Matthew J., Eriksson, Natalie A., Bailey, Peter, Pearen, Michael A, Fuller, Peter J., Funder, John W., Simpson, Evan R., Leedman, Peter J., Tilley, Wayne D., Brown, Melissa A., Clarke, Christine L. and Muscat, George E. O. (2012). Protein arginine methyltransferase 6-dependent gene expression and splicing: Association with breast cancer outcomes. Endocrine-Related Cancer, 19 (4), 509-526. doi: 10.1530/ERC-12-0100

Identification of fifteen novel germline variants in the BRCA1 3′UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site

Brewster, Brooke L., Rossiello, Francesca, French, Juliet D., Edwards, Stacey L., Wong, Ming, Wronski, Ania, Whiley, Phillip, Waddell, Nic, Chen, Xiaowei, Bove, Betsy, kConFab, Hopper, John L., John, Esther M., Andrulis, Irene, Daly, Mary, Volorio, Sara, Bernard, Loris, Peissel, Bernard, Manoukian, Siranoush, Barile, Monica, Pizzamiglio, Sara, Verderio, Paolo, Spurdle, Amanda B., Radice, Paolo, Godwin, Andrew K., Southey, Melissa C., Brown, Melissa A. and Peterlongo, Paolo (2012). Identification of fifteen novel germline variants in the BRCA1 3′UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site. Human Mutation, 33 (12), 1665-1675. doi: 10.1002/humu.22159

Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors

Smart, Chanel E., Askarian Amiri, Marjan E., Wronski, Ania, Dinger, Marcel E., Crawford, Joanna, Ovchinnikov, Dmitry A., Vargas, Ana Cristina, Reid, Lynne, Simpson, Peter T., Song, Sarah, Wiesner, Christiane, French, Juliet D., Dave, Richa K., da Silva, Leonard, Purdon, Amy, Andrew, Megan, Mattick, John S., Lakhani, Sunil R., Brown, Melissa A. and Kellie, Stuart (2012). Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors. PLoS One, 7 (7) e40742, e40742.1-e40742.13. doi: 10.1371/journal.pone.0040742

Androgen receptor expression predicts breast cancer survival: The role of genetic and epigenetic events

Peters, Kate M., Edwards, Stacey L., Nair, Shalima S., French, Juliet D., Bailey, Peter J., Salkield, Kathryn, Stein, Sandra, Wagner, Sarah, Francis, Glenn D., Clark, Susan J. and Brown, Melissa A. (2012). Androgen receptor expression predicts breast cancer survival: The role of genetic and epigenetic events. BMC Cancer, 12 (132) 132, 1-10. doi: 10.1186/1471-2407-12-132

A guide for functional analysis of BRCA1 variants of uncertain significance

Millot, Gael A., Carvalho, Marcelo A., Caputo, Sandrine M., Vreeswijk, Maaike P. G., Brown, Melissa A., Webb, Michelle, Rouleau, Etienne, Hansen, Thomas v. O., Galli, Alvaro, Brand˜ao, Rita D., Blok, Marinus J., Velkova, Aneliya, Couch, Fergus J., Monteiro, Alvaro N. A. and ENIGMA (2012). A guide for functional analysis of BRCA1 variants of uncertain significance. Human Mutation, 33 (11), 1526-1537. doi: 10.1002/humu.22150

Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in adva

Wee, E.J.H., Peters, K., Nair, S.S., Hulf, T., Stein, S., Wagner, S., Bailey, P., Lee, S.Y., Qu, W.J., Brewster, B., French, J.D., Dobrovic, A., Francis, G.D., Clark, S.J. and Brown, M.A. (2012). Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in adva. Oncogene, 31 (38), 4182-4195. doi: 10.1038/onc.2011.584

p53-Dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage

Jiang, Juhong, Yang, Eddy S., Jiang, Guochun, Nowsheen, Somaira, Wang, Hong, Wang, Tong, Wang, Yihan, Billheimer, Dean, Chakravarthy, A. Bapsi, Brown, Melissa, Haffty, Bruce and Xia, Fen (2011). p53-Dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage. Cancer Research, 71 (16), 5546-5557. doi: 10.1158/0008-5472.CAN-10-3423

Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary

Whiley, Phillip J., Guidugli, Lucia, Walker, Logan C., Healey, Sue, Thompson, Bryony A., Lakhani, Sunil R., Da Silva, Leonard M., kConFab Investigators, Tavtigian, Sean V., Goldgar, David E., Brown, Melissa A., Couch, Fergus J. and Spurdle, Amanda B. (2011). Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary. Human Mutation, 32 (6), 678-687. doi: 10.1002/humu.21495

SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer

Askarian-Amiri, Marjan E., Crawford, Joanna, French, Juliet D., Smart, Chanel E., Smith, Martin A., Clark, Michael B., Ru, Kelin, Mercer, Tim R., Thompson, Ella R., Lakhani, Sunil R., Vargas, Ana C., Campbell, Ian G., Brown, Melissa A., Dinger, Marcel E. and Mattick, John S. (2011). SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. RNA, 17 (5), 878-891. doi: 10.1261/rna.2528811

Analysis of brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

Smart, C.E., Wronski, A., French, J.D., Edwards, S.L., Asselin-Labat, M.L., Waddell, N., Peters, K., Brewster, B.L., Brooks, K., Simpson, K., Manning, N., Lakhani, S.R., Grimmond, S., Lindeman, G.J., Visvader, J.E. and Brown, M.A. (2011). Analysis of brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit. Oncogene, 30 (13), 1597-1607. doi: 10.1038/onc.2010.538

ORAI1-mediated calcium influx in lactation and in breast cancer

McAndrew, Damara, Grice, Desma M., Peters, Amelia A., Davis, Felicity M., Stewart, Teneale, Rice, Michelle, Smart, Chanel E., Brown, Melissa A., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). ORAI1-mediated calcium influx in lactation and in breast cancer. Molecular Cancer Therapeutics, 10 (3), 448-460. doi: 10.1158/1535-7163.MCT-10-0923

Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers

Ramus, Susan J., Kartsonaki, Christiana, Gayther, Simon A., Pharoah, Paul D. P., Sinilnikova, Olga M., Beesley, Jonathan, Chen, Xiaoqing, McGuffog, Lesley, Healey, Sue, Couch, Fergus J., Wang, Xianshu, Fredericksen, Zachary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Allavena, Anna, Ottini, Laura, Papi, Laura, Gismondi, Viviana, Capra, Fabio, Radice, Paolo, Greene, Mark H., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord ... Lakhani, Sunil (2011). Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institiute, 103 (2), 105-116. doi: 10.1093/jnci/djq494

Constitutional methylation of the BRCA1 promoter Is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer

Wong, Ee Ming, Southey, Melissa C., Fox, Stephen B., Brown, Melissa A., Dowty, James G., Jenkins, Mark A., Giles, Graham G., Hopper, John L. and Dobrovic, Alexander (2011). Constitutional methylation of the BRCA1 promoter Is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer. Cancer Prevention Research, 4 (1), 23-33. doi: 10.1158/1940-6207.CAPR-10-0212

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Antoniou, Antonis C., Wang, Xianshu, Fredericksen, Zachary S., McGuffog, Lesley, Tarrell, Robert, Sinilnikova, Olga M., Healey, Sue, Morrison, Jonathan, Kartsonaki,Christiana, Lesnick, Timothy, Ghoussaini, Maya, Barrowdale, Daniel, Peock, Susan, Cook, Margaret, Oliver, Clare, Frost, Debra, Eccles, Diana, Evans, D. Gareth, Eeles, Ros, Izatt, Louise, Chu, Carol, Douglas, Fiona, Paterson, Joan, Stoppa-Lyonnet, Dominique, Houdayer, Claude, Mazoyer, Sylvie, Giraud, Sophie, Lasset, Christine, Remenieras, Audrey ... Lakhani, Sunil (2010). A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population. Nature Genetics, 42 (10), 885-892. doi: 10.1038/ng.669

Common genetic variants and modification of penetrance of BRCA2-associated breast cancer

Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn, Candace Guiducci, Ayellet V. Segre, Kate McGee, Lesley McGuffog, Christiana Kartsonaki, Jonathan Morrison, Sue Healey, Olga M. Sinilnikova, Dominique Stoppa-Lyonnet, Sylvie Mazoyer, Marion Gauthier-Villars, Hagay Sobol, Michel Longy, Marc Frenay, GEMO Study Collaborators, Frans B. L. Hogervorst, Matti a. Rookus, J. Margriet Collee, Nicoline Hoogerbrugge, Kees E. P. van Roozendaal, HEBON Study Collaborators, Marion Piedmonte, Wendy Rubinstein, Stacy Nerenstone ... Lakhani, Sunil (2010). Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genetics, 6 (10), e1001183-1-e1001183-12. doi: 10.1371/journal.pgen.1001183

Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers

Wang, Xianshu, Pankratz, V. Shane, Fredericksen, Zachary, Tarrell, Robert, Karaus, Mary, McGuffog, Lesley, Pharaoh, Paul D.P., Ponder, Bruce A.J., Dunning, Alison M., Peock, Susan, Cook, Margaret, Oliver, Clare, Frost, Debra, EMBRACE, Sinilnikova, Olga M., Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Houdayer, Claude, GEMO, Hogervorst, Frans B.L., Hooning, Maartje J., Ligtenberg, Marjolijn J., HEBON, Spurdle, Amanda, Chenevix-Trench, Georgia, kConFab, Schmutzler, Rita K., Wappenschmidt, Barbara, Engel, Christoph ... Lakhani, Sunil (2010). Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics, 19 (14), 2886-2897. doi: 10.1093/hmg/ddq174

Detection of Splicing Aberrations Caused by BRCA1 and BRCA2 Sequence Variants Encoding Missense Substitutions: Implications for Prediction of Pathogenicity

Walker, Logan C., Whiley, Phillip J., Couch, Fergus J., Farrugia, Daniel J., Healey, Sue, Eccles, Diana M., Lin, Feng, Butler, Samantha A., Goff, Sheila A., Thompson, Bryony A., Lakhani, Sunil R., Da Silva, Leonard M., Tavtigian, Sean V., Goldgar, David E., Brown, Melissa A. and Spurdle, Amanda B. (2010). Detection of Splicing Aberrations Caused by BRCA1 and BRCA2 Sequence Variants Encoding Missense Substitutions: Implications for Prediction of Pathogenicity. Human Mutation, 31 (6), E1484-E1505. doi: 10.1002/humu.21267

Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts

Whiley, Phillip J., Pettigrew, Christopher A., Brewster, Brooke L., Walker, Logan C., Spurdle, Amanda B. and Brown, Melissa A. (2010). Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts. BMC Medical Genetics, 11 (1) 80, 80-1-80-5. doi: 10.1186/1471-2350-11-80

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status

Flanagan, James M., Cocciardi, Sibylle, Waddell, Nic, Johnstone, Cameron N., Marsh, Anna, Henderson, Stephen, Simpson, Peter, da Silva, Leonard, kConFab Investigators, Khanna, Kumkum, Lakhani, Sunil, Boshoff, Chris, Chenevix-Trench, Georgia, Brown, Melissa, Cummings, Margaret and Edwards, Stacey (2010). DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status. American Journal of Human Genetics, 86 (3), 420-433. doi: 10.1016/j.ajhg.2010.02.008

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study

Milne, Roger L., Gaudet, Mia M., Spurdle, Amanda B., Fasching, Peter A., Couch, Fergus J., Benitez, Javier, Arias Perez, Jose Ignacio, Zamora, M. Pilar, Malats, Nuria, dos Santos Silva, Isabel, Gibson, Lorna J., Fletcher, Olivia, Johnson, Nichola, Anton-Culver, Hoda, Ziogas, Argyrios, Figueroa, Jonine, Brinton, Louise, Sherman, Mark E., Lissowska, Jolanta, Hopper, John L., Dite, Gillian S., Apicella, Carmel, Southey, Melissa C., Sigurdson, Alice J., Linet, Martha S., Schonfeld, Sara J., Freedman, D. Michal, Mannermaa, Arto, Kosma, Veli-Matti ... Lakhani, Sunil (2010). Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study. Breast Cancer Research, 12 (6) R110, R110.1-R110.11. doi: 10.1186/bcr2797

Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors

Arnold, Jeremy M., Choong, David Y. H., Thompson, Ella R., kConFab, Waddell, Nic, Lindeman, Geoffrey J., Visvader, Jane E., Campbell, Ian G., Chenevix-Trench, Georgia, Brown, Melissa, Cummings, Margaret and Edwards, Stacey (2010). Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors. Breast Cancer Research And Treatment, 119 (2), 491-496. doi: 10.1007/s10549-008-0269-x

Identification and functional analysis of novel BRCA1 transcripts, including mouse Brca1-Iris and human pseudo-BRCA1

Pettigrew, C. A., French, J. D., Saunus, J. M., Edwards, S. L., Sauer, A. V., Smart, C. E., Lundstrom, H. T., Wiesner, C., Spurdle, A. B., Rothnagel, J. A. and Brown, M. A. (2010). Identification and functional analysis of novel BRCA1 transcripts, including mouse Brca1-Iris and human pseudo-BRCA1. Breast Cancer Research and Treatment, 119 (1), 239-247. doi: 10.1007/s10549-008-0256-2

A novel synthetic adjuvant enhances dendritic cell function

Phillipps, Karen S. M., Wykes, Michelle N., Liu, Xue Q., Brown, Melissa, Blanchfield, Joanne T. and Toth, Istvan (2009). A novel synthetic adjuvant enhances dendritic cell function. Immunology, 128 (1), e582-e588. doi: 10.1111/j.1365-2567.2008.03038.x

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

Lim, Elgene, Vaillant, Francois, Wu, Di, Forrest, Natalie C., Pal, Bhupinder, Hart, Adam H., Asselin-Labat, Marie-Liesse, Gyorki, David E., Ward, Teresa, Partanen, Audrey, Feleppa, Frank, Huschtscha, Lily I., Thorne, Heather J., kConFab, Fox, Stephen B., Yan, Max, French, Juliet D., Brown, Melissa A., Smyth, Gordon K., Visvader, Jane E. and Lindemann, G. J. (2009). Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nature Medicine, 15 (8), 907-913. doi: 10.1038/nm.2000

Classifying MLH1 and MSH2 variants using bioinformatic prediction, splicing assays, segregation, and tumor characteristics

Arnold, Sven, Buchanan, Daniel D., Barker, Melissa, Jaskowski, Lesley, Walsh, Michael D., Birney, Genevieve, Woods, Michael O., Hopper, John L., Jenkins, Mark A., Brown, Melissa A., Tavtigian, Sean V., Goldgar, David E., Young, Joanne P. and Spurdle, Amanda B. (2009). Classifying MLH1 and MSH2 variants using bioinformatic prediction, splicing assays, segregation, and tumor characteristics. Human Mutation, 30 (5), 757-770. doi: 10.1002/humu.20936

Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21

Fung, Jackie Mei-Wah Fung, Smith, Ross, Brown, Melissa A., Lau, Sze Hang, Xie, Dan, Lau, George K. and Guan, Xin-Yuan (2009). Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21. Clinical Cancer Research, 15 (3), 797-803. doi: 10.1158/1078-0432.CCR-08-1472

Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR

Saunus, J., French, J.D., Edwards, S.L., Beveridge, D.J., Hatchell, E.C., Wagner, S.A., Stein, S.R., Davidson, A., Simpson, K.J., Francis, G.D., Leedman, P.J. and Brown, M.A. (2008). Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR. Cancer Research, 68 (22), 9469-9478. doi: 10.1158/0008-5472.CAN-08-1159

Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia

Smart, Chanel E., Clarke, Catherine, Brooks, Kelly M., Raghavendra, Ashwini, Brewster, Brooke L., French, Juliet D., Hetherington, Rehan, Fleming, Jean S., Rothnagel, Joseph A., Wainwright, Brandon, Lakhani, Sunil R. and Brown, Melissa A. (2008). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Breast Cancer Research and Treatment, 112 (2), 237-241. doi: 10.1007/s10549-007-9859-2

Colocalisation of predicted exonic splicing enhancers in BRCA2 with reported sequence variants

Pettigrew, Christopher A., Wayte, Nicola, Wronski, Ania, Lovelock, Paul K., Spurdle, Amanda B. and Brown, Melissa A. (2008). Colocalisation of predicted exonic splicing enhancers in BRCA2 with reported sequence variants. Breast Cancer Research and Treatment, 110 (2), 227-234. doi: 10.1007/s10549-007-9714-5

BRCA1 and BRCA2 missense variants of high and low clinical significance influence lymphoblastoid cell line post-irradiation gene expression

Waddell, N, Ten Haaf, A, Marsh, A, Johnson, J, Walker, LC, Gongora, M, Brown, M, Grover, P, Girolami, M, Grimmond, S, Chenevix-Trench, G, Spurdle, AB and kConFab Investigators (2008). BRCA1 and BRCA2 missense variants of high and low clinical significance influence lymphoblastoid cell line post-irradiation gene expression. PLoS Genetics, 4 (5) e1000080, Article Number: e1000080. doi: 10.1371/journal.pgen.1000080

Localization of plasma membrane and secretory calcium pumps in the mammary gland

Faddy, Helen M., Smart, Chanel E., Xu, Ren, Lee, Genee Y., Kenny, Paraic A., Feng, Mingye, Rao, Rajini, Brown, Melissa A., Bissell, Mina J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2008). Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochemical and Biophysical Research Communications, 369 (3), 977-981. doi: 10.1016/j.bbrc.2008.03.003

Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene

Tan-Wong, Sue Mei, French, Juliet D., Proudfoot, Nicholas J. and Brown, Melissa A. (2008). Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. Proceedings of the National Academy of Sciences of the United States of America, 105 (13), 5160-5165. doi: 10.1073/pnas.0801048105

Breast cancer type 1 susceptibility protein

French, J.D. and Brown, M.A. (2008). Breast cancer type 1 susceptibility protein. CurrentBioData

Clinical classification of BRCA1 and BRCA2 DNA sequence variants: The value of cytokeratin profiles and evolutionary analysis - A report from the kConFab Investigators

Spurdle, A.B., Lakhani, S.R., Healey, S., Parry, S., Da Silva, L. M., Brinkworth, R.I., Hopper, J.L., Brown, M.A., Babikyan, D., Chenevix-Trench, G., Tavtigian, S.V. and Goldgar, D.E. (2008). Clinical classification of BRCA1 and BRCA2 DNA sequence variants: The value of cytokeratin profiles and evolutionary analysis - A report from the kConFab Investigators. Journal of Clinical Oncology, 26 (10), 1657-1663. doi: 10.1200/JCO.2007.13.2779

Pre-mRNA splicing aberrations and cancer

Pettigrew, C.A. and Brown, M.A. (2008). Pre-mRNA splicing aberrations and cancer. Frontiers In Bioscience, 13 (13), 1090-1105. doi: 10.2741/2747

Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?

Lovelock, Paul K., Spurdle, Amanda B., Mok, Myth T. S., Farrugia, Daniel J., Lakhani, Sunil R., Healey, Sue, Arnold, Stephen, Buchanan, Daniel, kConFab Investigators, Couch, Fergus J., Henderson, Berik R., Goldgar, David E., Tavtigian, Sean V., Chenevix-Trench, Georgia and Brown, Melissa A (2007). Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?. Breast Cancer Research, 9 (6: R82) R82, 1-13. doi: 10.1186/bcr1826

Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell-line phenotypic variability

Lovelock, Paul K., Wong, Ee Ming, Sprung, Carl N., Marsh, Anna, Hobson, Karen, French, Juliet D., Southey, Melissa, kConFab Investigators, Sculley, Tom, Pandeya, Nirmala, Brown, Melissa A., Chenevix-Trench, Georgia, Spurdle, Amanda B. and McKay, Michael J. (2007). Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell-line phenotypic variability. Breast Cancer Research and Treatment, 104 (3), 257-266. doi: 10.1007/s10549-006-9415-5

Genome-wide association study identifies novel breast cancer susceptibility loci

Easton, Douglas F., Pooley, Karen A., Dunning, Alison M., Pharoah, Paul D. P., Thompson, Deborah, Ballinger, Dennis G., Struewing, Jeffery P., Morrison, Jonathan, Field, Helen, Luben, Robert, Wareham, Nicholas, Ahmed, Shahana, Healey, Catherine S., Bowman, Richard, SEARCH collaborators, Meyer, Kerstin B., Haiman, Christopher A., Kolonel, Laurence K., Henderson, Brian E., Marchand, Loic Le, Brennan, Paul, Sangrajrang, Suleeporn, Gaborieau, Valerie, Odefrey, Fabrice, Shen, Chen-Yang, Wu, Pei-Ei, Wang, Hui-Chun, Eccles Diana, Evans, D. Gareth ... Ward, Robyn (2007). Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447 (7148), 1087-1093. doi: 10.1038/nature05887

Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression

Saunus, Jodi M., Edwards, Stacey L., French, Juliet D., Smart, Chanel E. and Brown, Melissa A. (2007). Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression. FEBS Letters, 581 (18), 3435-3442. doi: 10.1016/j.febslet.2007.06.046

Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants

Lovelock P. K., Healey, S., Au, W., Sum, E, Y. M., Tesoriero, A., Wong, E. M., Hinson, S., Brinkworth, R., Bekessy, A., Diez, O., Izatt, L., Solomon, E., Jenkins, M., Renard, H., Hopper, J., Waring, P., kConFab Investigators, Tavtigian, S. V., Goldgar, D., Lindeman, G J ., Visvader, J. E., Couch, F. J., Henderson, B. R., Southey, M., Chenevix-Trench, G., Spurdle, A. B. and Brown, M. A. (2006). Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants. Journal of Medical Genetics, 43 (1), 74-83. doi: 10.1136/jmg.2005.033258

Disruption of BRCA I function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines

French, Juliet D., Dunn, Jasmyn, Smart, Chanel E., Manning, Nathan and Brown, Melissa A. (2006). Disruption of BRCA I function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines. Genes Chromosomes and Cancer, 45 (3), 277-289. doi: 10.1002/gcc.20290

Genetic and Histopathologic Evaluation of BRCA1 and BRCA2 DNA Sequence Variance of Unknown Clinical Significance

Chenevix-Trench, Georgia, Healey, Sue, Lakhani, Sunil, Waring, Paul, Cummings, Margaret, Brinkworth, Ross, Deffenbaugh, Amie M., Burbidge, Lynn Anne, Pruss, Dmitry, Judkins, Thad, Scholl, Tom, Bekessy, Anna, Marsh, Anna, Lovelock, Paul, Wong, Ming, Tesoriero, Andrea, Renard, Helene, Southey, Melissa, Hopper, John L., Yannoukakos, Koulis, Brown, Melissa, kConFab Investigators, Easton, Douglas, Tavtigian, Sean V., Goldgar, David and Spurdle, Amanda B. (2006). Genetic and Histopathologic Evaluation of BRCA1 and BRCA2 DNA Sequence Variance of Unknown Clinical Significance. Cancer Research, 66 (4), 2019-2027. doi: 10.1158/0008-5472.CAN-05-3546

Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer

Lewis, Aaron G., Flanagan, James, Marsh, Anna, Pupo, Gulietta M., Mann, Graham, Spurdle, Amanda B., Lindeman, Geoffrey J., Visvader, Jane E., Brown, Melissa A., Chenevix-Trench, Georgia and KConFab, Kathleen Cuningham Foundation (2005). Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer. Breast Cancer Research, 7 (6) R1005, R1005-R1016. doi: 10.1186/bcr1336

Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1 gene with missense sequence changes and in-frame deletions, but not polymorphisms

Pettigrew, Christopher, Wayte, Nicola, Lovelock, Paul K., Tavtigian, Sean V, Chenevix-Trench, Georgia, Spurdle, Amanda B. and Brown, Melissa A. (2005). Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1 gene with missense sequence changes and in-frame deletions, but not polymorphisms. Breast Cancer Research, 7 (6), R929-R939. doi: 10.1186/bcr1324

Identification of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene

Wardrop, Stacey L., Brown, Melissa A. and kConFab Investigators (2005). Identification of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene. Genomics, 86 (3), 316-328. doi: 10.1016/j.ygeno.2005.05.006

Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation

He, Y. W., Brown, M. A., Rothnagel, J. A., Saunders, N. A. and Smith, R. (2005). Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation. Journal of Cell Science, 118 (14), 3173-3183. doi: 10.1242/jcs.02448

Method for the generation and cultivation of functional three-dimensional mammary constructs without exogenous extracellular matrix

Timmins, N. E., Harding, F. J., Smart, C. E., Brown, M. A. and Nielsen, L. K. (2005). Method for the generation and cultivation of functional three-dimensional mammary constructs without exogenous extracellular matrix. Cell And Tissue Research, 320 (1), 207-210. doi: 10.1007/s00441-004-1064-6

Molecular characterization and cancer risk associated with BRCA1 and BRCA2 splice site variants identified in multiple-case breast cancer families

Tesoriero, A. A., Wong, E. M., Jenkins, M. A., Hopper, J. L., KConFab, K. C. F., Brown, M. A., Chenevix-Trench, G., Spurdle, A. B. and Southey, M. C. (2005). Molecular characterization and cancer risk associated with BRCA1 and BRCA2 splice site variants identified in multiple-case breast cancer families. Human Mutation, 26 (5), 495-495. doi: 10.1002/humu.9379

MMTV-trBrca 1 mice display strain-dependent abnormalities in vaginal development

Simpson, K. J., Wati, M. R., Deans, A. J., Lindeman, G. J. and Brown, M. A. (2004). MMTV-trBrca 1 mice display strain-dependent abnormalities in vaginal development. International Journal of Developmental Biology, 48 (7), 675-678. doi: 10.1387/ijdb.041849ks

Brca1 inactivation induces p27Kip1-dependent cell cycle arrest and delayed development in the mouse mammary gland

Deans, Andrew J., Simpson, Kaylene J., Trivett, Melanie K., Brown, Melissa A. and McArthur, Grant (2004). Brca1 inactivation induces p27Kip1-dependent cell cycle arrest and delayed development in the mouse mammary gland. Oncogene, 23 (36), 6136-6145. doi: 10.1038/sj.onc.1207805

Roles of heterogeneous nuclear ribonucleoproteins A/B in cell growth

He, Y., Brown, M. A., Rothnagel, J. A., Saunders, N. A. and Smith, R. (2004). Roles of heterogeneous nuclear ribonucleoproteins A/B in cell growth. Molecular Biology of The Cell, 15, 252A-253A.

Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice

Brown, M. A., Nicolai, H., Howe, K., Katagiri, T., Lalani, E., Simpson, K. J., Manning, N. W., Deans, A., Chen, P., Khanna, K. K., Wati, M. R., Griffiths, B. L., Xu, C. F., Stamp, G. W. H. and Solomon, E. (2002). Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice. Transgenic Research, 11 (5), 467-478. doi: 10.1023/A:1020348025139

Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1 :psi VBRCA1 recombination

Brown, M. A., Lo, L. J., Catteau, A., Xu, C. F., Lindeman, G. J., Hodgson, S. and Solomon, E. (2002). Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1 :psi VBRCA1 recombination. Human Mutation, 19 (4), 435-442. doi: 10.1002/humu.10055

Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice

Lane, T. F., Lin, C. W., Brown, M. A., Solomon, E. and Leder, P. (2000). Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice. Oncogene, 19 (36), 4085-4090. doi: 10.1038/sj.onc.1203760

Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions

Catteau, A., Xu, C. F., Brown, M. A., Hodgson, S., Greenman, J., Mathew, C. G., Dunning, A. M. and Solomon, E. (1999). Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions. British Journal of Cancer, 79 (5-6), 759-763. doi: 10.1038/sj.bjc.6690122

Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene

Xu, CF, Brown, MA, Nicolai, H, Chambers, JA, Griffiths, BL and Solomon, E (1997). Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. Human Molecular Genetics, 6 (7), 1057-1062. doi: 10.1093/hmg/6.7.1057

Studies on inherited cancers: Outcomes and challenges of 25 years

Brown, MA and Solomon, E (1997). Studies on inherited cancers: Outcomes and challenges of 25 years. Trends in Genetics, 13 (5), 202-206. doi: 10.1016/S0168-9525(97)01132-3

Mutations and alternative splicing of the BRCAI gene in UK breast/ovarian cancer families

Xu, CF, Chambers, JA, Nicolai, H, Brown, MA, Hujeirat, Y, Mohammed, S, Hodgson, S, Kelsell, DP, Spurr, NK, Bishop, DT and Solomon, E (1997). Mutations and alternative splicing of the BRCAI gene in UK breast/ovarian cancer families. Genes Chromosomes & Cancer, 18 (2), 102-110. doi: 10.1002/(SICI)1098-2264(199702)18:2<102::AID-GCC4>3.0.CO;2-6

Tumor suppressor genes and human cancer

Brown, MA (1997). Tumor suppressor genes and human cancer. Advances in Genetics, Vol 36, 36 (C), 45-135. doi: 10.1016/S0065-2660(08)60307-7

The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21

Brown, MA, Xu, CF, Nicolai, H, Griffiths, B, Chambers, JA, Black, D and Solomon, E (1996). The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21. Oncogene, 12 (12), 2507-2513.

Distinct Transcription Start Sites Generate 2 Forms of Brca1 Messenger-Rna

Xu, CF, Brown, MA, Chambers, JA, Griffiths, B, Nicolai, H and Solomon, E (1995). Distinct Transcription Start Sites Generate 2 Forms of Brca1 Messenger-Rna. Human Molecular Genetics, 4 (12), 2259-2264. doi: 10.1093/hmg/4.12.2259

Physical Mapping, Cloning, and Identification of Genes Within a 500-Kb Region Containing Brca1

Brown, MA, Jones, KA, Nicolai, H, Bonjardim, M, Black, D, McFarlane, R, Dejong, P, Quirk, JP, Lehrach, H and Solomon, E (1995). Physical Mapping, Cloning, and Identification of Genes Within a 500-Kb Region Containing Brca1. Proceedings of the National Academy of Sciences of the United States of America, 92 (10), 4362-4366. doi: 10.1073/pnas.92.10.4362

Molecular genetics of sporadic and familial breast cancer

Jones, KA, Brown, MA and Solomon, E (1995). Molecular genetics of sporadic and familial breast cancer. Cancer Surveys, 25, 315-334.

Regulation of Brca1

Brown, MA, Nicolai, H, Xu, CF, Griffiths, BL, Jones, KA, Solomon, E, Hosking, L, Trowsdale, J, Black, DM and McFarlane, R (1994). Regulation of Brca1. Nature, 372 (6508), 733-733. doi: 10.1038/372733a0

The Detailed Characterization of a 400-Kb Cosmid Walk in the Brca1 Region - Identification and Localization of 10 Genes Including a Dual-Specificity Phosphatase

Jones, KA, Black, DM, Brown, MA, Griffiths, BL, Nicolai, HM, Chambers, JA, Bonjardim, M, Xu, CF, Boyd, M, McFarlane, R, Korn, B, Poustka, A, North, MA, Schalkwyk, L, Lehrach, H and Solomon, E (1994). The Detailed Characterization of a 400-Kb Cosmid Walk in the Brca1 Region - Identification and Localization of 10 Genes Including a Dual-Specificity Phosphatase. Human Molecular Genetics, 3 (11), 1927-1934.

No Evidence for Gm-Csf Receptor a Chain Gene Mutation in Aml-M2 Leukemias Which Have Lost a Sex-Chromosome

Brown, MA, Harrisonsmith, M, Deluca, E, Begley, CG and Gough, NM (1994). No Evidence for Gm-Csf Receptor a Chain Gene Mutation in Aml-M2 Leukemias Which Have Lost a Sex-Chromosome. Leukemia, 8 (10), 1774-1779.

Leukemia Inhibitory Factor (lif) Infusion Stimulates Skeletal-Muscle Regeneration After Injury - Injured Muscle Expresses Lif Messenger-Rna

Barnard, W, Bower, J, Brown, MA, Murphy, M and Austin, L (1994). Leukemia Inhibitory Factor (lif) Infusion Stimulates Skeletal-Muscle Regeneration After Injury - Injured Muscle Expresses Lif Messenger-Rna. Journal of the Neurological Sciences, 123 (1-2), 108-113. doi: 10.1016/0022-510X(94)90211-9

Leukemia Inhibitory Factor and Interleukin-6 Are Expressed At Very-Low Levels in the Normal Adult-Mouse and Are Induced by Inflammation

Brown, MA, Metcalf, D and Gough, NM (1994). Leukemia Inhibitory Factor and Interleukin-6 Are Expressed At Very-Low Levels in the Normal Adult-Mouse and Are Induced by Inflammation. Cytokine, 6 (3), 300-309. doi: 10.1016/1043-4666(94)90027-2

Involvement of Leukemia Inhibitory Factor and Nerve Growth-Factor in the Development of Dorsal-Root Ganglion Neurons

Murphy, M, Reid, K, Brown, MA and Bartlett, PF (1993). Involvement of Leukemia Inhibitory Factor and Nerve Growth-Factor in the Development of Dorsal-Root Ganglion Neurons. Development, 117 (3), 1173-1182.

Structure and Expression of the Gm-Csf Receptor Alpha-Chain and Beta-Chain Genes in Human Leukemia

Brown, MA, Gough, NM, Willson, TA, Rockman, S and Begley, CG (1993). Structure and Expression of the Gm-Csf Receptor Alpha-Chain and Beta-Chain Genes in Human Leukemia. Leukemia, 7 (1), 63-74.

MOLECULAR-BIOLOGY OF THE LEUKEMIA INHIBITORY FACTOR GENE

GOUGH, NM, WILLSON, TA, STAHL, J and BROWN, MA (1992). MOLECULAR-BIOLOGY OF THE LEUKEMIA INHIBITORY FACTOR GENE. Ciba Foundation Symposia, 167, 24-46.

Alternatively Spliced Rnas Encode Several Isoforms of Cd46 (mcp), a Regulator of Complement Activation

Purcell, Dfj, Russell, SM, Deacon, NJ, Brown, MA, Hooker, DJ and McKenzie, Ifc (1991). Alternatively Spliced Rnas Encode Several Isoforms of Cd46 (mcp), a Regulator of Complement Activation. Immunogenetics, 33 (5-6), 335-344. doi: 10.1007/BF00216692

Virus-Neutralizing and Passively Protective Monoclonal-Antibodies to Infectious Bursal Disease Virus of Chickens

Fahey, KJ, McWaters, P, Brown, MA, Erny, K, Murphy, VJ and Hewish, DR (1991). Virus-Neutralizing and Passively Protective Monoclonal-Antibodies to Infectious Bursal Disease Virus of Chickens. Avian Diseases, 35 (2), 365-373. doi: 10.2307/1591191

Characterization of Cytokine Production by the Metrial Gland and Granulated Metrial Gland-Cells

Croy, BA, Guilbert, LJ, Browne, MA, Gough, NM, Stinchcomb, DT, Reed, N and Wegmann, TG (1991). Characterization of Cytokine Production by the Metrial Gland and Granulated Metrial Gland-Cells. Journal of Reproductive Immunology, 19 (2), 149-166.

Osteoblasts Display Receptors for and Responses to Leukemia-Inhibitory Factor

Allan, EH, Hilton, DJ, Brown, MA, Evely, RS, Yumita, S, Metcalf, D, Gough, NM, Ng, KW, Nicola, NA and Martin, TJ (1990). Osteoblasts Display Receptors for and Responses to Leukemia-Inhibitory Factor. Journal of Cellular Physiology, 145 (1), 110-119. doi: 10.1002/jcp.1041450116

Structural organization of the genes for murine and human leukemia inhibitory factor: evolutionary conservation of coding and non-coding regions

Stahl, Juergen, Gearing, David P., Willson, Tracy A., Brown, Melissa A., King, Julie A. and Gough, Nicholas M. (1990). Structural organization of the genes for murine and human leukemia inhibitory factor: evolutionary conservation of coding and non-coding regions. Journal of Biological Chemistry, 265 (15), 8833-8841.

Deletion Mapping and Expression in Escherichia-Coli of the Large Genomic Segment of a Birnavirus

Azad, AA, Jagadish, MN, Brown, MA and Hudson, PJ (1987). Deletion Mapping and Expression in Escherichia-Coli of the Large Genomic Segment of a Birnavirus. Virology, 161 (1), 145-152. doi: 10.1016/0042-6822(87)90180-2

RNA immunoprecipitation reveals lncRNA-protein interactions in basal-like breast cancer

Northwood, K., Saunus, J., Milevskiy, M., Lakhani, S. and Brown, M. (2017). RNA immunoprecipitation reveals lncRNA-protein interactions in basal-like breast cancer. San Antonio Breast Cancer Symposium, San Antonio TX, United States, 6-10 December 2016. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS16-P1-04-05

Bioinformatic and experimental evaluation of regulatory variants in breast cancer susceptibility genes

Sevcik, Jan, Burke, Leslie, Gambino, Gaetana, Brewster, Brooke L., Tudini, Emma, Whiley, Philip J., Manoukian, Siranoush, Hansen, Thomas van Overeem, Pena, Marta Santamarina, Vega, Ana, Caligo, Maria A., Radice, Paolo, Peterlongo, Paolo, Rouleau, Etienne, Spurdle, Amanda B. and Brown, Melissa A. (2016). Bioinformatic and experimental evaluation of regulatory variants in breast cancer susceptibility genes. AACR 107th Annual Meeting on Bioinformatics and Systems Biology, New Orleans, LA, United States, 16-20 April, 2016. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2016-1859

Transient Receptor Potential Cation Channel V4 (TRPV4) expression in breast cancer subtypes and potential expression regulators in breast cancer cells

Lim, Huai F., Northwood, Korinne, Milevskiy, Michael, Peters, Amelia A., Brown, Melissa, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2015). Transient Receptor Potential Cation Channel V4 (TRPV4) expression in breast cancer subtypes and potential expression regulators in breast cancer cells. APSA ASCEPT Joint Scientific Meeting 2015, Hobart, TAS, Australia, 29 November - 2 December 2015.

Investigating the role of ncRNAs in breast cancer associated DNA methylation

Northwood, orinne, Milevskiy, Michael and Brown, Melissa (2014). Investigating the role of ncRNAs in breast cancer associated DNA methylation. International Association for Breast Cancer Research, Sydney , Australia, 14-17 September 2014.

Cardiac transplantation for chemotherapy induced cardiomyopathy: Demographics and long term follow-up

McKenzie, S.C., Sharma, A., Chee, K.W., Platts, D., Javorskky, G. and Brown, M. (2012). Cardiac transplantation for chemotherapy induced cardiomyopathy: Demographics and long term follow-up. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2012.01.448

The role of Orai1 and Stim2 in mammary epithelial cell calcium influx in the murine mammary gland

McAndrew, D., Kenny, P. A., Brown, M. A., Smart, C. E., Roberts-Thomson, S. J. and Monteith, G. R. (2009). The role of Orai1 and Stim2 in mammary epithelial cell calcium influx in the murine mammary gland. Combio2009, Christchurch, New Zealand, 6-10 Decemeber 2009. Canterbury, New Zealand: University of Canterbury.

Calcium channels in the mammary gland: Expression and function in lactation, and potential breast cancer targets

McAndrew, D., Rice, M. L., Smart, C. E., Brown, M. A., Roberts-Thomson, S. J. and Monteith, G. R. (2008). Calcium channels in the mammary gland: Expression and function in lactation, and potential breast cancer targets. Australian Health and Medical Research Congress (AHMRC) 2008, Brisbane, Australia, 16-21 November 2008. Sydney, Australia: AHMRC.

Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene

French, J. D., Tan-Wong, S. M., Edwards, S., Smart, C. E., Proudfoot, N. J. and Brown, M. A. (2008). Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. Fifth European Gordon Research Conference on Mammary Gland Biology, Lucca (Barga), Italy, 1-6 June 2008.

Identification of functional regulatory elements in the non-coding regions of the BRCA1 gene

French, J. D., Edwards, S. L., Saunus, J. M., Tan-Wong, S. M., Brewster, B., Hardie, K. M., Leedman, P. J., Proudfoot, N. J. and Brown, M. A. (2008). Identification of functional regulatory elements in the non-coding regions of the BRCA1 gene. kConFab Familial Breast Cancer conference 2008, Couran Cove, Queensland, 2008.

Calcium influx pathways during mammary gland development and lactation

Rice, M. L., Stewart, T. A., Smart, C. E., McAndrew, D., Faddy, H. M., Brown, M. A., Roberts-Thomson, S. J. and Monteith, G. R. (2007). Calcium influx pathways during mammary gland development and lactation. ComBio 2007, Sydney, 22-26 September 2007.

Calcium transport in the mammary gland: A role for secretory pathway calcium ATPase 2 (SPCA2) in normal physiology and breast cancer

Faddy, H. M., Smart, C. E., Brown, M. A., Feng, M., Rao, R., Roberts-Thomson, S. J. and Monteith, G. R. (2007). Calcium transport in the mammary gland: A role for secretory pathway calcium ATPase 2 (SPCA2) in normal physiology and breast cancer. ComBio 2007, Sydney, 22-26 September 2007.

Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene

French, J. D., Wong, S. M., Saunus, J. M., Smart, C. E., Proudfoot, N. J. and Brown, M. A. (2007). Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. Australian Breast Cancer Conference 2007, Melbourne, Australia, 19-20 November 2007.

Identification of novel mutation targets in the breast cancer susceptibility gene BRCA1 and genes that encode regulators of BRCA1

Brewster, B., Brown, M. A., Edwards, S. L., French, J. D., Leedman, P., Proudfoot, N. J., Saunus, J. M., Southey, M., Tavtigian, S and Wong, S. M. (2007). Identification of novel mutation targets in the breast cancer susceptibility gene BRCA1 and genes that encode regulators of BRCA1. kConFab Familial Breast Cancer Conference, Couran Cove, Queensland, 21-24 August 2007.

Secretory pathway Ca2+_ATPase isoforms in mouse lactation and in human breast cancer

Roberts-Thomson, S. J., Faddy, H. M., Smart, C. E., Brown, M. A., Xu, R., Lee, G. Y., Kenny, P. A., Bissell, M. J., Feng, M., Rao, R. and Monteith, G. R. (2007). Secretory pathway Ca2+_ATPase isoforms in mouse lactation and in human breast cancer. Australian Breast Cancer Conference 2007, Bio 21 Institute, Melbourne, 19-20 November 2007.

Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia

Smart, C. E., Clarke, C., Brooks, K. M., Raghavendra, A., Brewster, B. L., French, J. D., Hetherington, R., Fleming, J. S., Rothnagel, J. A., Wainwright, B., Lakhani, S. R. and Brown, M. A. (2007). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Australian Breast Cancer Conference, Melbourne, Australia, 2007.

Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia

Brewster, Brooke, Brooks, Kelly, Brown, Melissa Anne, Clarke, C., Fleming, J. S., French, J. D., Hetherington, Rehan, Lakhani, Sunil, Raghavendra, Ashwini, Rothnagel, Joseph, Smart, Chanel and Wainwright, Brandon (2007). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Gordon Research Conference: Mammary Gland Biology, Newport, RI, 10-15 June 2007.

Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia

Brewster, Brooke, Brooke, Kelly, Brown, Melissa Anne, Clarke, C., Fleming, J. S., French, J. D., Hetherington, Rehan, Lakhani, Sunil, Raghavendra, Ashwini, Rothnagel, Joseph, Smart, Chanel and Wainwright, Brandon (2007). Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. kConFab Familial Breast Cancer Conference, Couran Cove, Queensland, 21-24 August 2007.

A role for secretory pathway calcium atpase 2 (SPCA2) in calcium transport, breast cancer and mammary gland development

Faddy, H. M., Smart, C. E., Brown, M. A., Roberts-Thomson, S. J. and Monteith, G. R. (2006). A role for secretory pathway calcium atpase 2 (SPCA2) in calcium transport, breast cancer and mammary gland development. ComBio 2006, Brisbane / Brisbane Convention Centre, 24-28 September 2006. Kent Town, South Australia: Australian Society for Biochemistry and Molecular Biology.

Cellular and molecular changes in mammary epithelial cells with disrupted BRCA1 function

Smart, C. E., Simpson, K. J., Manning, N. W. and Brown, M. A. (2006). Cellular and molecular changes in mammary epithelial cells with disrupted BRCA1 function. Gordon Conference on Mammary Gland Biology, Il Ciocco, 30 May 2006.

Identification of RNA-binding proteins that regulate BRCA1 expression

Saunus, Jodi M., French, Juliet D., Edwards, Stacey L., Beveridge, Dianne J., Hatchell, Esme C., Wagner, Sarah A., Gason, Alexandra A., Simpson, Kaylene J., Leedman, Peter J. and Brown, Melissa A. (2006). Identification of RNA-binding proteins that regulate BRCA1 expression. Familial Cancer 2006: Research and Practice. A combined meeting of kConFab, Australian Ovarian Cancer Study (AOCS) and the Family Cancer Clinics of Australia and New Zealand, Couran Cove, South Stradbroke Island, Queensland, Australia, 16-19 August 2006. Kathleen Cuningham Foundation Consortium (kConFab).

Post-transcriptional regulation of the breast cancer susceptibility gene BRCA1 by Hu Antigen-R

Saunus, Jodi M., Wardrop, Stacey L., French, Juliet D., Beveridge, Dianne J., Hatchell, Esme C., Dinnis, Diane M., Gason, Alexandra A., Simpson, Kaylene J., Leedman, Peter J. and Brown, Melissa A. (2006). Post-transcriptional regulation of the breast cancer susceptibility gene BRCA1 by Hu Antigen-R. ComBio 2006, Brisbane, Queensland, Australia, 24-28 September, 2006.

Altered cytokeratin and vimentin expression in mammary epithelial cells with disrupted BRCA1 function

Smart, C. E., Simpson, K. J., Manning, N. W., Karunaratne, S. M., Edwards, S., Yap, A. S. K., Rothnagel, J. A., Visvader, J. E., Lindeman, G. J. and Brown, M. A. (2005). Altered cytokeratin and vimentin expression in mammary epithelial cells with disrupted BRCA1 function. Familial Cancer 2005: Research and Practice, Couran Cove, 30 Aug - 3 Sept, 2005.

Evolutionary conservation analysis may help identify functional exonic splice enhancer motifs in BRCA1 and BRCA2

Brown, M. A., Chenevix-Trench, G., Lovelock, P. K., Pettigrew, C., Spurdle, A. B., Tavtigian, S. and Wayte, N. J. (2005). Evolutionary conservation analysis may help identify functional exonic splice enhancer motifs in BRCA1 and BRCA2. Familial Cancer 2005: Research and Practice, Couran Cove, Queensland, 30 August - 3 September, 2005.

Genetic and immunohistopathological evaluation of BRCA1 and BRCA2 unclassified variants

Chenevix-Trench, G., Healey, S. C., Lakhani, S., Brinkworth, R. I., KConFab, K. C. F., Marsh, A., Brown, M. A., Easton, D. F., Tavtigian, S., Goldgar, D. E. and Spurdle, A. B. (2005). Genetic and immunohistopathological evaluation of BRCA1 and BRCA2 unclassified variants. Familial Cancer 2005: Research and Practice, Couran Cove, Queensland, 30 August - 3 September, 2005.

Hur post-transcriptionally regulates BRCA1: involvement of elements in the BRCA1 3' untranslated region

Saunus, J. M., Wardrop, S. L., French, J. D., Beveridge, D. J., Hatchell, E. C., Gason, A. A., Simpson, K.J., Leedman, P. J. and Brown, M. A. (2005). Hur post-transcriptionally regulates BRCA1: involvement of elements in the BRCA1 3' untranslated region. Molecular Approaches to Controlling Cancer, New York, 3-5 June, 2005.

Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell line phenotypic variability

Brown, M. A., Chenevix-Trench, G., French, J. D., Hobson, K., KConFab Investigators, Lovelock, P. K., Marsh, A., McKay, M., Pandeya, N., Sculley, T., Southey, M. C., Sprung, C. N., Spurdle, A. B. and Wong, E. M. (2005). Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell line phenotypic variability. Familial Cancer 2005: Research and Practice, Couran Cove, 30 August - 3 September, 2005.

Regulation of BRCA1 by Heregulin

French, J. D., Saunus, J. M., Wardrop, S. L. and Brown, M. A. (2005). Regulation of BRCA1 by Heregulin. Familial Cancer 2005: Research and Practice, Couran Cove, 30 Aug - 3 Sept, 2005.

Transcriptional and post-transcriptional regulation of the breast cancer susceptibility gene 1 (BRCA1)

Wardrop, S. L., Saunus, J. M., French, J. D., Leedman, P. J. and Brown, M. A. (2005). Transcriptional and post-transcriptional regulation of the breast cancer susceptibility gene 1 (BRCA1). National Cancer Research Institute Conference, Birmingham, UK, 2-5 Oct, 2005.

A role for BRCA1 in mammary epithelial morphogenesis, differentiation and adhesion

Manning, N. W., Simpson, K. J., Karunaratne, S. M., Yap, A. S. K., Visvader, J. E., Lindeman, G. J. and Brown, M. A. (2002). A role for BRCA1 in mammary epithelial morphogenesis, differentiation and adhesion. Australian Health & Medical Research Conference, Melbourne, Australia, November, 2002.

Identification of cis and trans regulators in the BRCA1 3'untranslated region

Saunus, J. M., Wardrop, S. L. and Brown, M. A. (2002). Identification of cis and trans regulators in the BRCA1 3'untranslated region. ComBio 2002, Sydney, Australia, 29 September - 3 October, 2002. Kent Town, South Australia:

Identification of critical regulatory elements in the breast cancer susceptibility (BRCA1) gene

Wardrop, S. L., Lane, T. and Brown, M. A. (2002). Identification of critical regulatory elements in the breast cancer susceptibility (BRCA1) gene. ComBio 2002, Sydney, Australia, 29 September - 3 October, 2002. Kent Town, South Australia:

Investigating a role for BRCA1 in telomere maintenance

French, J., Manning, N.W., Robinson, S. E., Karunaratne, S. M., Reddel, R. and Brown, M. A. (2002). Investigating a role for BRCA1 in telomere maintenance. Australian Telomere Workshop, Sydney, Australia, 2002. Kent Town, South Australia:

Familial Breast/ovarian Cancer - Progress Towards Isolation of a Predisposing Gene

Jones, K, Black, D, Nicolai, H, Griffiths, B, Bonjardim, M, Brown, M, North, M, Schwalkwyk, L, Lehrach, H, Korn, B, Poustka, A and Solomon, E (1994). Familial Breast/ovarian Cancer - Progress Towards Isolation of a Predisposing Gene. NEW YORK: WILEY-LISS.

Molecular-Biology of the Leukemia Inhibitory Factor Gene

Gough, NM, Willson, TA, Stahl, J and Brown, MA (1992). Molecular-Biology of the Leukemia Inhibitory Factor Gene. Symp On Polyfunctional Cytokines : Il-6 ( Interleukin 6 ) and Lif ( Leukemia Inhibitory Factor ), London England, Oct 01-03, 1991. CHICHESTER: JOHN WILEY & SONS LTD.