Professor Elizabeth Coulson

Professor and Deputy Head of School

School of Biomedical Sciences
Faculty of Medicine

Professor

Queensland Brain Institute
elizabeth.coulson@uq.edu.au
+61 7 336 59022

Overview

Professor Elizabeth (Lizzie) Coulson did her undergraduate Honours degree at the University of Melbourne, majoring in Genetics and Biochemistry. Her PhD (1997) in the Department of Pathology, University of Melbourne, with Professor Colin Masters, was on the normal function of the amyloid precursor protein of Alzheimer’s disease. Following a year at the ZMBH, University of Heidelberg, Germany, she pursued postdoctoral work studying neuronal cell death in neurodegeneration and development at the Walter and Eliza Hall Institutewith Professor Perry Bartlett before being recruited in 2003 to the University of Queensland as a founding member of the Queensland Brain Institute. She was appointed Professor in 2015, joining the School of Biomedical Sciences and becoming Deputy Head of School in 2019. She maintains a 20% Queensland Brain Institutes appointment and is a member of the Clem Jones Centre for Ageing Dementia Research.

Her Lab webpage is: Coulson Lab - Neurotrophin - School of Biomedical Sciences ...

Research Interests

  • Role of p75NTR in neurodegenerative disease.
    The laboratory recently reported that p75NTR death signalling can be promoted by amyloid-ß peptide that characteristically accumulates in Alzheimer’s disease. We are investigating the regulation and activation of p75NTR death signalling in cholinergic neurons in this condition, and testing whether disrupting p75NTR function can prevent cholinergic degeneration, and cognitive decline, in animal models. As an extension of this work we are developing methods to assess cholinergic degeneration and amyloid plaque deposition in animal models of Alzheimer’s disease by magnetic resonance imaging (MRI).
  • How neurotransmitter- and neurotrophin-mediated signals determine cell survival.
    We are investigating the basic molecular mechanisms by which neurotransmitter receptor activation and receptor trafficking affect p75NTR activation and subsequent death signalling using molecular and biochemical techniques in in vitro and in vivo models. We are also investigating the role of p75NTR cleavage in promoting death signalling, using confocal microscopy techniques to image live cells and cell membranes in real time. This project will lead to a greater understanding of p75NTR biology, and will also provide knowledge of the kinetics of p75NTR-mediated death signals and the time frame within which they can be inhibited.

Qualifications

  • PhD, University of Melbourne
  • BSc (Hons), University of Melbourne

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Skeldal, S. and Coulson, E. J. (2016). Signaling and function of death receptors of the tumor necrosis factor receptor superfamily. Encyclopedia of cell biology. (pp. 67-75) edited by Ralph A. Bradshaw and Philip D. Stahl. Waltham, MA United States: Academic Press. doi: 10.1016/B978-0-12-394447-4.30011-6

  • Hawkins, Christine J., Coulson, Elizabeth J. and Vaux, David L. (2005). Baculoviral lessons in apoptosis. Signalling pathways in apoptosis. (pp. 196-209) edited by Dianne Watters and Martin Lavin. Abingdon, United Kingdom: Taylor & Francis. doi: 10.4324/9780203303658_chapter_7

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Master Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision